Margie N. Sutton, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Director of Education, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2017 | MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, Texas, US, Cancer Biology, Ph.D |
| 2010 | The University of Texas at San Antonio, San Antonio, Texas, US, Chemistry, Biology, BS |
Postgraduate Training
| 2018-2022 | Research Fellowship, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2017-2018 | Research Fellowship, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Academic Appointments
Instructor, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - 2024
Administrative Appointments/Responsibilities
Director of Education, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2024 - Present
Other Appointments/Responsibilities
Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2022
Research Scientist I, The University of Texas at San Antonio, San Antonio, TX, 2011 - 2011
Institutional Committee Activities
Member, Faculty Senate, 2022 - 2025
Honors & Awards
| 2022 | Linda K. Manning Ovarian Cancer Endowed Research Award, The University of Texas MD Anderson Cancer Center |
| 2020 | Ruth L. Kirchstein Postdoctoral Individual Research Service Award (F32) Fellow, National Cancer Institute |
| 2020 | Harold C. and Mary L. Dailey Endowed Fellowship Recognition of Research Excellence, The University of Texas MD Anderson Cancer Center |
| 2019 | Diane Denson Tobola Endowed Fellowship in Ovarian Cancer Research, The University of Texas MD Anderson Cancer Center |
| 2018 | AACR Scholar-in-Training Award Annual Meeting, American Association for Cancer Research |
| 2017 | Clyde H. Wright Memorial Fund Travel Award, Department of Experimental Therapeutics |
| 2017 | Ann and Sol Schreiber Mentored Investigator Award, Ovarian Cancer Research Fund Alliance |
| 2016 | Shohrae Hajibashi Memorial Leadership Award, UTHealth Houston |
| 2013 | Thomas F. Burks Outstanding Leadership and Service Award, UTHealth Houston |
| 2013 | NIH CCTS TL1 Fellow in Translational Research, GSBS Houston |
| 2013 | American Legion Auxiliary Fellow in Cancer Research, GSBS Houston |
| 2010 | Phi Beta Kappa, Phi Beta Kappa Society |
| 2009 | Jane Findling Award, The University of Texas at San Antonio |
| 2007 | Campus Honors College, The University of Texas at San Antonio |
| 2007 | Dean's List, The University of Texas at San Antonio |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Sutton MN, Glazer SE, Muzzioli R, Yang P, Gammon ST, Piwnica-Worms D. Dimerization of the 4Ig isoform of B7-H3 in tumor cells mediates enhanced proliferation and tumorigenic signaling. Commun Biol 7(1):21, 2024. e-Pub 2024. PMID: 38182652.
- Engel BJ, Paolillo V, Uddin MN, Gonzales KA, McGinnis KM, Sutton MN, Patnana M, Grindel BJ, Gores GJ, Piwnica-Worms D, Beretta L, Pisaneschi F, Gammon ST, Millward SW. Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging. Cancers (Basel) 15(15), 2023. e-Pub 2023. PMID: 37568603.
- Engel BJ, Paolillo V, Uddin MN, Gonzalez KA, McGinnis KM, Sutton MN, Grindel BJ, Gores GJ, Piwnica-Worms D, Beretta L, Pisaneschi F, Gammon ST, Millward SW. Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed by Multi-modal Imaging. Cancers, 2023. e-Pub 2023.
- Sutton MN, Gammon ST, Muzzioli R, Pisaneschi F, Radaram B, Yang P, Piwnica-Worms D. RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging. Mol Imaging Biol 24(3):498-509, 2022. e-Pub 2022. PMID: 34905147.
- Rao Y, Gammon ST, Sutton MN, Zacharias NM, Bhattacharya P, Piwnica-Worms D. Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner. J Biol Chem 297(1):100775, 2021. e-Pub 2021. PMID: 34022218.
- Gray JP, Uddin MN, Chaudhari R, Sutton MN, Yang H, Rask P, Locke H, Engel BJ, Batistatou N, Wang J, Grindel BJ, Bhattacharya P, Gammon ST, Zhang S, Piwnica-Worms D, Kritzer JA, Lu Z, Bast RC, Millward SW. Directed evolution of cyclic peptides for inhibition of autophagy. Chem Sci 12(10):3526-3543, 2021. e-Pub 2021. PMID: 34163626.
- Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. Proc Natl Acad Sci U S A 117(22):12121-12130, 2020. e-Pub 2020. PMID: 32424096.
- Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC. DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. Cell Rep 29(11):3448-3459.e6, 2019. e-Pub 2019. PMID: 31825828.
- Simmons AR, Fourkala EO, Gentry-Maharaj A, Ryan A, Sutton MN, Baggerly K, Zheng H, Lu KH, Jacobs I, Skates S, Menon U, Bast RC. Complementary Longitudinal Serum Biomarkers to CA125 for Early Detection of Ovarian Cancer. Cancer Prev Res (Phila) 12(6):391-400, 2019. e-Pub 2019. PMID: 30967390.
- Sutton MN, Huang GY, Zhou J, Mao W, Langley R, Lu Z, Bast RC. Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression. Cancers (Basel) 11(5), 2019. e-Pub 2019. PMID: 31052266.
- Mao W, Peters HL, Sutton MN, Orozco AF, Pang L, Yang H, Lu Z, Bast RC. The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts. Cancer 125(8):1267-1280, 2019. e-Pub 2019. PMID: 30620384.
- Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RC. DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1. Cancers (Basel) 11(4), 2019. e-Pub 2019. PMID: 31003488.
- Sutton MN, Yang H, Huang GY, Fu C, Pontikos M, Wang Y, Mao W, Pang L, Yang M, Liu J, Parker-Thornburg J, Lu Z, Bast RC. RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells. Autophagy 14(4):637-653, 2018. e-Pub 2018. PMID: 29368982.
- Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC, Millward SW. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16(1):824, 2016. e-Pub 2016. PMID: 27784287.
- Morgado M, Sutton MN, Simmons M, Warren CR, Lu Z, Constantinou PE, Liu J, Francis LL, Conlan RS, Bast RC, Carson DD. Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget 7(12):14871-84, 2016. e-Pub 2016. PMID: 26918940.
- Washington MN, Suh G, Orozco AF, Sutton MN, Yang H, Wang Y, Mao W, Millward S, Ornelas A, Atkinson N, Liao W, Bast RC, Lu Z. ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. Cell Death Dis 6:e1836, 2015. e-Pub 2015. PMID: 26247722.
- Lu Z, Yang H, Sutton MN, Yang M, Clarke CH, Liao WS, Bast RC. ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7. Cell Death Differ 21(8):1275-89, 2014. e-Pub 2014. PMID: 24769729.
Other Articles
- Bildik G, Liang X, Sutton MN, Bast RC, Lu Z DIRAS3: An Imprinted Tumor Suppressor Gene that Regulates RAS and PI3K-driven Cancer Growth, Motility, Autophagy, and Tumor Dormancy. Mol Cancer Ther 21(1):25-37, 2022. PMID: 34667114.
Abstracts
- Glazer SE, Sutton MN, Yang P, Gammon ST, Piwnica-Worms D. Single Dose Treatment with a Novel Yttrium-90-labeled High Affinity Anti-B7-H3 Antibody Selective for the 4Ig-B7-H3 Isoform Provides Long Term Survivors for Established Radioresistant Colorectal Carcinoma. AACR Annual Meeting Orlando, FL, 2023. e-Pub 2023.
- Sutton MN, Glazer SE, Muzzioli R, Yang P, Gammon ST, Piwnica-Worms D. Statins Inhibit Onco-dimerization of B7-H3. AACR Annual Meeting Orlando, FL, 2023. e-Pub 2023.
- Glazer SE, Sutton MN, Yang P, Pisaneschi F, Gammon ST, Piwnica-Worms, D. A novel high affinity anti-B7H3 antibody selective for the 4Ig-B7H3 isoform when labeled with ytrrium-90 provides long term survivors for established radioresistant colorectal carcinoma when administered as a single-dose treatment. Society of Nuclear Medicine & Molecular Imaging, 2023. e-Pub 2023.
- Engel BJ, Paolillo V, Uddin MN, Gonzales K, Sutton MN, Grindel B, Gores GJ, Piwnica-Worms D, Beretta L, Pisaneschi F, Gammon ST, Millward SW. Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed by Multi-modal Imaging. WMIC Annual Meeting 2023 Chicago, IL.
Book Chapters
- Sutton MN, Lu Z, Bast RC. The role of Angiogenesis, Growth Arrest and Autophagy in Human Ovarian Cancer Xenograft Models for Tumor Dormancy. In: Autophagy: Cancer, Other Pathogens, Inflammation, Immunity, Infection and Aging. 1st, 2014.
- Jackson LE, Sutton MN. Barotrauma and Decompression Sickness. In: Encyclopedia of Otolaryngology, Head and Neck Surgery. Springer, 2013.
Selected Presentations & Talks
Local Presentations
- 2024. From Drug Screen to Therapeutic Target: The Potential of Statins as 4lg-B7-H3-depenent Immune Modulators. Invited. Texas A&M University Drug Discovery Center and Rice University SynthesisX Center. Houston, TX, US.
- 2023. Panel Discussion: Imaging Immune Response. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2023. Statins Inhibit Onco-dimerization of B7-H3: A Link Between Cholesterol Metabolism and Tumor Immunobiology. Invited. 12th Annual Metabolism in Cancer Symposium 2023. Houston, TX, US.
- 2020. In Vivo Fluorescence Imaging Reveals Target Engagement of Mutation Specific RAS-inhibitor, ARS-1620. Invited. Recognition of Research Excellence, Trainee Research Day. Houston, TX, US.
- 2016. Autophagy and Cancer dormancy: strategies to eliminate dormant drug resistant cancer cells. Invited. Autophagy in Health and Disease. Houston, TX, US.
- 2014. Panel Discussion Leader: Applying for Funding. Conference. American Physician Scientists Association South Regional Meeting. Houston, TX, US.
National Presentations
- 2017. DIRAS3 disrupts RAS multimeters at the plasma membrane. Invited. The Second RAS Initiative Symposium Sponsored by the National Cancer Institute. Frederick, MD, US.
International Presentations
- 2023. RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging. Invited. United Scientific Group. N/A, US.
Grant & Contract Support
| Date: | 2024 - 2025 |
| Title: | Molecular Imaging of Innate Inflammation in Response to Statin-Mediated Inhibition of B7-H3 dimerization |
| Funding Source: | MD Anderson QIAC Partnership in Research Program |
| Role: | Co-PI |
Patient Reviews
CV information above last modified April 02, 2025