Marian Kalocsay, Ph.D.

Peer-Reviewed Articles

1. McVeigh, BM, De Jesús-Pérez, JJ, Siepe, D, Gogoi, P, Mageswaran, SK, Kalocsay, M, Mihelc, E, Moiseenkova-Bell, V. Visualization of lysosomal membrane proteins by cryo electron tomography. Nature communications 16(1), 2025. e-Pub 2025. PMID: 41107240.
2. Deng X, Bradshaw GA, Kalocsay M, Mitchison T. Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form. J Cell Biol 224(12), 2025. e-Pub 2025. PMID: 41171096.
3. Das LT, Malvezzi M, Gade A, Matsui M, McKay M, Wei EQ, Zelich MJ, Mazdisnian K, Kushner J, Chen BX, DiStefano I, Roybal D, Yang L, Stoll L, Lo JC, Kalocsay M, Akar FG, Marx SO, Pitt GS. FGF13 Regulates VGSC-Independent Cardiomyocyte Impulse Propagation via Cx43 Trafficking. Circ Res, 2025. e-Pub 2025. PMID: 41200819.
4. Psenakova K, Parhad SS, Paulo JA, Liu X, Patterson EF, Watson R, Cheek MA, Keogh MC, Kalocsay M, Gygi SP, Farnung L, Moazed D. Catalytic pocket of Clr4 (Suv39h) methyltransferase serves as a substrate receptor for Cullin 4-dependent histone H3 ubiquitination. bioRxiv, 2025. e-Pub 2025. PMID: 40909655.
5. Das T, Bradshaw GA, Hyer J, Masek M, Kuo YM, Bachmann-Gagescu R, Kalocsay M, Nachury MV. BBSome-Mediated Clearance of Ubiquitinated IMPG2 Defines a Constitutive Ciliary Retrieval Pathway in Photoreceptors. bioRxiv, 2025. e-Pub 2025. PMID: 40766594.
6. Van Itallie E, Sonnett M, Kalocsay M, Wuhr M, Peshkin L, Kirschner MW. Transitions in the proteome and phospho-proteome during Xenopus laevis development. Dev Biol 525:155-171, 2025. e-Pub 2025. PMID: 40466852.
7. Rodriques A, Liu G, Katchman A, Zakharov S, Wan E, Kalocsay M, Eisert R, Bradshaw GA, Chen BX, Yang L, Reiken S, Lai X, Ji R, Saadallah N, Topkara V, Fanourakis S, Yuan Q, Kushner J. Probing the Ca(V)1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy. bioRxiv, 2025. e-Pub 2025. PMID: 40463082.
8. Gui F, Jiang B, Jiang J, He Z, Tsujino T, Takai T, Arai S, Pana C, Köllermann J, Bradshaw GA, Eisert R, Kalocsay M, Fassl A, Balk SP, Kibel AS, Jia L. Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer. Science Advances 11(17), 2025. e-Pub 2025. PMID: 40267193.
9. Vidović D, Shamsaei B, Schürer SC, Kogan P, Chojnacki S, Kouril M, Medvedovic M, Niu W, Azeloglu EU, Birtwistle MR, Chen Y, Chen T, Hansen J, Hu B, Iyengar R, Jayaraman G, Li H, Liu T, Sobie EA, Xiong Y, Berberich MJ, Bradshaw G, Chung M, Everley RA, Gaudio B, Hafner M, Kalocsay M, Mills CE, Nariya MK, Sorger PK, Subramanian K, Victor C, Banuelos M, Dardov V, Holewinski R, Manalo D, Mandefro B, Matlock AD, Ornelas L, Sareen D, Svendsen CN, Vaibhav V, Van Eyk JE, Venkatraman V, Finkbiener S, Fraenkel E, Rothstein J, Thompson L, Asiedu J, Carr SA, Christianson KE, Davison D, Dele-Oni DO, DeRuff KC, Egri SB, Vaca Jacome AS, Jaffe JD, Lam D, Litichevskiy L, Lu X, Mullahoo J, Officer A, Papanastasiou M, Peckner R, Toder C, Blanchard J, Bula M, Ko T, Tsai L, Young JZ, Sharma V, Pillai A, Meller J, MacCoss MJ. Comprehensive proteomics metadata and integrative web portals facilitate sharing and integration of LINCS multiomics data. Mol Cell Proteomics 24(7), 2025. e-Pub 2025. PMID: 40089066.
10. Marx DC, Gonzalez-Hernandez AJ, Huynh K, Strauss A, Rico C, Siepe D, Gallo P, Lee J, Sharghi S, Arefin A, ProfileJohannes Broichhagen VO, Eliezer D, Kalocsay M, ProfileGeorge Khelashvili VO, Levitz J. Structural Diversity of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling, 2025. PMID: 39975168.
11. Deng X, Bradshaw G, Kalocsay M, Mitchison T. Tubulin Regulates the Stability and Localization of STMN2 by Binding Preferentially to Its Soluble Form. bioRxiv. e-Pub 2025. PMID: 40060442.
12. Gallo, PN, Mihelc, E, Eisert, RJ, Bradshaw, GA, Dimek, F, Leffler, A, Kalocsay, M, Moiseenkova-Bell, V. The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth. Cell Calcium 121, 2024. e-Pub 2024. PMID: 38728789.
13. Susa KJ, Bradshaw GA, Eisert RJ, Schilling CM, Kalocsay M, Blacklow SC, Kruse AC. A spatiotemporal map of co-receptor signaling networks underlying B cell activation. Cell Rep 43(6):114332, 2024. e-Pub 2024. PMID: 38850533.
14. Konig LE, Rodriguez S, Hug C, Daneshvari S, Chung A, Bradshaw GA, Sahin A, Zhou G, Eisert RJ, Piccioni F, Das S, Kalocsay M, Sokolov A, Sorger P, Root DE, Albers MW. TYK2 as a novel therapeutic target in Alzheimer's Disease with TDP-43 inclusions. bioRxiv, 2024. e-Pub 2024. PMID: 38895380.
15. Deng X, Seguinot BO, Bradshaw G, Lee JS, Coy S, Kalocsay M, Santagata S, Mitchison T. STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases. Mol Biol Cell 35(6):ar82, 2024. e-Pub 2024. PMID: 38630521.
16. Kalocsay M, Berberich MJ, Everley RA, Nariya MK, Chung M, Gaudio B, Victor C, Bradshaw GA, Eisert RJ, Hafner M, Sorger PK, Mills CE, Subramanian K. Proteomic profiling across breast cancer cell lines and models. Sci Data 10(1):514, 2023. e-Pub 2023. PMID: 37542042.
17. Martin AP, Bradshaw GA, Eisert RJ, Egan ED, Tveriakhina L, Rogers JM, Dates AN, Scanavachi G, Aster JC, Kirchhausen T, Kalocsay M, Blacklow SC. A spatiotemporal Notch interaction map from plasma membrane to nucleus. Sci Signal 16(796):eadg6474, 2023. e-Pub 2023. PMID: 37527352.
18. Zhou M, Fang R, Colson L, Donovan KA, Hunkeler M, Song Y, Zhang C, Chen S, Lee DH, Bradshaw GA, Eisert R, Ye Y, Kalocsay M, Goldberg A, Fischer ES, Lu Y. HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates. bioRxiv, 2023. e-Pub 2023. PMID: 37398461.
19. Susa KJ, Bradshaw GA, Eisert RJ, Schilling CM, Kalocsay M, Blacklow SC, Kruse AC. A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation. bioRxiv, 2023. e-Pub 2023. PMID: 36993395.
20. Papa A, Zakharov SI, Katchman AN, Kushner JS, Chen BX, Yang L, Liu G, Jimenez AS, Eisert RJ, Bradshaw GA, Dun W, Ali SR, Rodriques A, Zhou K, Topkara V, Yang M, Morrow JP, Tsai EJ, Karlin A, Wan E, Kalocsay M, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO. Rad regulation of Ca(V)1.2 channels controls cardiac fight-or-flight response. Nat Cardiovasc Res 1(11):1022-1038, 2022. e-Pub 2022. PMID: 36424916.
21. Fraser CS, Spetz JKE, Qin X, Presser A, Choiniere J, Li C, Yu S, Blevins F, Hata AN, Miller JW, Bradshaw GA, Kalocsay M, Sanchorawala V, Sarosiek S, Sarosiek KA. Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics. Nat Commun 13(1):5789, 2022. e-Pub 2022. PMID: 36184661.
22. Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, Zhang J, Luo Z, Gygi SP, Adelman K, Moazed D. Rixosomal RNA degradation contributes to silencing of Polycomb target genes. Nature 604(7904):167-174, 2022. e-Pub 2022. PMID: 35355014.
23. Jimenez A, Lu D, Kalocsay M, Berberich MJ, Balbi P, Jambhekar A, Lahav G. Time-series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations. Mol Syst Biol 18(3):e10588, 2022. e-Pub 2022. PMID: 35285572.
24. Li L, Galichon P, Xiao X, Figueroa-Ramirez AC, Tamayo D, Lee JJ, Kalocsay M, Gonzalez-Sanchez D, Chancay MS, McCracken KW, Lee NN, Ichimura T, Mori Y, Valerius MT, Wilflingseder J, Lemos DR, Edelman ER, Bonventre JV. Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep 22(6):e51169, 2021. e-Pub 2021. PMID: 34031962.
25. Jiang B, Gao Y, Che J, Lu W, Kaltheuner IH, Dries R, Kalocsay M, Berberich MJ, Jiang J, You I, Kwiatkowski N, Riching KM, Daniels DL, Sorger PK, Geyer M, Zhang T, Gray NS. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol 17(6):675-683, 2021. e-Pub 2021. PMID: 33753926.
26. May EA, Kalocsay M, D'Auriac IG, Schuster PS, Gygi SP, Nachury MV, Mick DU. Time-resolved proteomics profiling of the ciliary Hedgehog response. J Cell Biol 220(5), 2021. e-Pub 2021. PMID: 33856408.
27. Drouin A, Wallbillich N, Theberge M, Liu S, Katz J, Bellovoda K, Se Yun Cheon S, Gootkind F, Bierman E, Zavras J, Berberich MJ, Kalocsay M, Guastaldi F, Salvadori N, Troulis M, Fusco DN. Impact of Zika virus on the human type I interferon osteoimmune response. Cytokine 137:155342, 2021. e-Pub 2021. PMID: 33130337.
28. Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin JR, Hurst KE, de Oliveira Taveira M, Johnson NT, Oldham WM, Kalocsay M, Berberich MJ, Boswell SA, Kothari A, Johnson S, Dillon DA, Lipschitz M, Rodig S, Santagata S, Garber JE, Tung N, Yélamos J, Thaxton JE, Mittendorf EA, Sorger PK, Shapiro GI, Guerriero JL. Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer. Nat Cancer 2(1):66-82, 2021. e-Pub 2021. PMID: 33738458.
29. Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D. A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin. Elife 9, 2020. e-Pub 2020. PMID: 32491985.
30. Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol 22(4):372-379, 2020. e-Pub 2020. PMID: 32231306.
31. Nusinow DP, Szpyt J, Ghandi M, Rose CM, McDonald ER, Kalocsay M, Jané-Valbuena J, Gelfand E, Schweppe DK, Jedrychowski M, Golji J, Porter DA, Rejtar T, Wang YK, Kryukov GV, Stegmeier F, Erickson BK, Garraway LA, Sellers WR, Gygi SP. Quantitative Proteomics of the Cancer Cell Line Encyclopedia. Cell 180(2):387-402.e16, 2020. e-Pub 2020. PMID: 31978347.
32. Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Jia H, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J. Structure of the human metapneumovirus polymerase phosphoprotein complex. Nature 577(7789):275-279, 2020. e-Pub 2020. PMID: 31698413.
33. Mugahid D, Kalocsay M, Liu X, Gruver JS, Peshkin L, Kirschner MW. YAP regulates cell size and growth dynamics via non-cell autonomous mediators. Elife 9, 2020. e-Pub 2020. PMID: 31913124.
34. Liu G, Papa A, Katchman AN, Zakharov SI, Roybal D, Hennessey JA, Kushner J, Yang L, Chen BX, Kushnir A, Dangas K, Gygi SP, Pitt GS, Colecraft HM, Ben-Johny M, Kalocsay M, Marx SO. Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics. Nature 577(7792):695-700, 2020. e-Pub 2020. PMID: 31969708.
35. Wang Y, Dix MM, Bianco G, Remsberg JR, Lee HY, Kalocsay M, Gygi SP, Forli S, Vite G, Lawrence RM, Parker CG, Cravatt BF. Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs. Nat Chem 11(12):1113-1123, 2019. e-Pub 2019. PMID: 31659311.
36. Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol 26(6):804-817.e12, 2019. e-Pub 2019. PMID: 30930164.
37. Kalocsay M. APEX Peroxidase-Catalyzed Proximity Labeling and Multiplexed Quantitative Proteomics. Methods Mol Biol 2008:41-55, 2019. e-Pub 2019. PMID: 31124087.
38. Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D. Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability. Nature 560(7719):504-508, 2018. e-Pub 2018. PMID: 30051891.
39. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell 172(1-2):106-120.e21, 2018. e-Pub 2018. PMID: 29249356.
40. Paek J, Kalocsay M, Staus DP, Wingler L, Pascolutti R, Paulo JA, Gygi SP, Kruse AC. Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling. Cell 169(2):338-349.e11, 2017. e-Pub 2017. PMID: 28388415.
41. Renkawitz J, Lademann CA, Kalocsay M, Jentsch S. Monitoring homology search during DNA double-strand break repair in vivo. Mol Cell 50(2):261-72, 2013. e-Pub 2013. PMID: 23523370.
42. Kalocsay M, Hiller NJ, Jentsch S. Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break. Mol Cell 33(3):335-43, 2009. e-Pub 2009. PMID: 19217407.
43. Jasiak AJ, Hartmann H, Karakasili E, Kalocsay M, Flatley A, Kremmer E, Strasser K, Martin DE, Soding J, Cramer P. Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex. J Biol Chem 283(39):26423-7, 2008. e-Pub 2008. PMID: 18667430.
44. Rape M, Hoppe T, Gorr I, Kalocay M, Richly H, Jentsch S. Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell 107(5):667-77, 2001. e-Pub 2001. PMID: 11733065.

Review Articles

1. Kushner JS, Liu G, Eisert RJ, Bradshaw GA, Pitt GS, Hinson JT, Kalocsay M, Marx SO. Detecting Cardiovascular Protein-Protein Interactions by Proximity Proteomics. Circ Res 130(2):273-287, 2022. e-Pub 2022. PMID: 35050691.

Other Articles

1. Vidović, D, Shamsaei, B, Schürer, S, Kogan, P, Chojnacki, S, Kouril, M, Medvedovic, M, Niu, W, Azeloglu, EU, Birtwistle, MR, Chen, Y, Chen, T, Hansen, J, Hu, B, Iyengar, R, Jayaraman, G, Li, H, Liu, T, Sobie, EA, Xiong, Y, Berberich, MJ, Bradshaw, GA, Chung, M, Everley, RA, Gaudio, B, Hafner, M, Kalocsay, M, Mills, CE, Nariya, MK, Sorger, PK, Subramanian, K, Victor, C, Banuelos, M, Dardov, V, Holewinski, R, Manalo, DM, Mandefro, B, Matlock, A, Ornelas, L, Sareen, D, Svendsen, CN, Vaibhav, V, van Eyk, JE, Venkatraman, V, Finkbiener, S, Fraenkel, E, Rothstein, JD, Thompson, L, Asiedu, J, Carr, SA, Christianson, KE, Davison, D, Dele-Oni, DO, DeRuff, KC, Egri, SB, Vaca Jacome, AS, Jaffe, JD, Lam, D, Litichevskiy, L, Lu, X, Mullahoo, J, Officer, A, Papanastasiou, M, Peckner, R, Toder, C, Blanchard, J, Bula, M, Ko, T, Tsai, LH, Young, JZ, Sharma, V, Meller, J, MacCoss, MJ Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data". Molecular and Cellular Proteomics 24(7):100995, 2025. PMID: 40783300.
2. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell 172(3):629-631, 2018. PMID: 29373832.

Patents

1. Marx SO, Kushnir A, Zakharov S, Katchman A, Gygi SP, Kalocsay M, Manu B, Colecraft HM, Guoxia LIU. Novel approach for increasing contractility in patients with systolic heart failure. Patent Number: 17624497.