Marites Pasuelo Melancon, Ph.D.
Department of Interventional Radiology, Division of Diagnostic Imaging
About Dr. Melancon
Dr. Marites Melancon is a Professor in the Department of Interventional Radiology at The University of Texas, M.D. Anderson Cancer Center. She received her PhD in Biomedical Science at The University of Texas-Health Science Center at Houston Graduate School of Biomedical Science in December 2007. She then trained in the Department of Imaging Physics as an Odyssey Fellow from 2009-2012 and was promoted to Instructor prior to joining Interventional Radiology working on the synthesis, characterization and in vivo evaluation of multimodality and multifunctional nanoparticles for image-guided therapy. Her main goal is to apply the "seek and treat" strategy in the development of targeted imaging/therapeutic agents that will eventually be translated to the clinic to improve the management of various diseases through early detection and individualized therapy. In addition, she is also developing radiopaque absorbable medical devices for vascular and interventional applications.
Present Title & Affiliation
Primary Appointment
Professor, Department of Interventional Radiology, Division of Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Graduate School of Biomedical Science, The University of Texas Health Science Center, Houston, TX
Research Interests
Nanotechnology, absorbable medical device, drug delivery, image-guided therapy, molecular imaging and ablation therapies
Education & Training
Degree-Granting Education
| 2007 | The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, US, Biomedical Science, Ph.D |
| 2000 | Ateneo de Manila University, Manila, PH, Chemistry, M.S |
| 1994 | University of San Carlos, Cebu, PH, Chemistry, BS |
Postgraduate Training
| 2008-2011 | Odyssey Fellow, Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2008-2008 | Postdoctoral Research, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Academic Appointments
Associate Professor, Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2023
Assistant Professor, Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2018
Instructor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2012
Instructor, Department of Chemistry, Ateneo de Manila University, Manila, 2000 - 2002
Administrative Appointments/Responsibilities
Director, Odyssey and Summer Experience Programs, Department of Education and Training, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2024
Other Appointments/Responsibilities
Lecturer, Texas Southern University, Houston, TX, 2012 - 2020
Institutional Committee Activities
Member, Small Animal Imaging Facility Internal Advisory Board, 2023 - Present
Member, Institutional Research Grant, 2018 - Present
Member, Postdoctoral Advisory Committee, 2016 - 2024
Ex Officio Member, Graduate Education Committee, 2016 - 2024
Member, Education Council, 2016 - 2024
Chair, Odyssey Program, 2015 - 2016
Member, Faculty Academic Review Committee (FARC), 2014 - 2017
Vice Chair, Odyssey Program, 2014 - 2015
Member, Odyssey Program, 2013 - 2014
IR Faculty Representative, DI Research Functional Committee, 2013 - 2015
Honors & Awards
| 2024 | Balik Scientist Award, Department of Science and Technology, Philippines |
| 2023 | Academy for Radiology & Biomedical Imaging Research's Council of Distinguished Investigators Class of 2023, Radiological Society for North America |
| 2023 | Distinguished Investigator (DI) Award, Academy for Radiology & Biomedical Imaging Research |
| 2017 | Carl Storm Underrepresented Minority (CSURM) Fellowship, Gordon Research Conference |
| 2016 | Early Career Reviewer, NIH Center for Scientific Review (NOIT) |
| 2016 | Robert Chamberlain Distinguished Mentor Award Finalist, MD Anderson Postdoc Association |
| 2015 | Council on Cardiovascular Radiology & Intervention Minority Travel Stipend, American Heart Association |
| 2014 | Balik Scientist Awardee, Department of Science and Technology, Manila, Philippines |
| 2010 | Finalist, Young Investigator Award, World Molecular Imaging Congress, Kyoto, Japan |
| 2010 | Student Travel Award, World Molecular Imaging Congress, Kyoto, Japan |
| 2010 | Trainee Excellence Award, The University of Texas MD Anderson Cancer Center |
| 2009 | Odyssey Fellowship, The University of Texas MD Anderson Cancer Center |
| 2009 | Student Travel Award, World Molecular Imaging Congress, Montreal, Canada |
| 2008 | Finalist, Young Investigator Award, World Molecular Imaging Congress, Nice, France |
| 2008 | Student Travel Award, World Molecular Imaging Congress, Nice, France |
| 2000 | Dean’s Award for Best Graduate Research, Ateneo de Manila University, Philippines |
| 1997 | Department of Science and Technology - Philippine Council for Advanced Science and Technology Research and Development (DOST-PCASTRD) Scholarship, Philippine Council for Advanced Science and Technology Research and Development (DOST-PCASTRD), Philippines |
| 1994 | Cum Laude, University of San Carlos, Cebu Philippines |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Wu Y, Lee TH, Cheng OH, Peden E, Li Q, Wang J, Huang F, Melancon MP, Sheikh-Hamad D, Wang T, Truong L, Mitch W, Liang M, Cheng J. Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula via YAP1 Signaling. J Am Soc Nephrol, 2025. PMID: 39883520.
- Barcena AJR, Perez JVD, Bernardino MR, Damasco JA, San Valentin EMD, Klusman C, Martin B, Canlas GM, Heralde FM 3rd, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Bismuth-infused perivascular wrap facilitates delivery of mesenchymal stem cells and attenuation of neointimal hyperplasia in rat arteriovenous fistulas. Biomater Adv 166:214052, 2024. e-Pub 2024. PMID: 39341164.
- Yu G, Corn PG, Mak CSL, Liang X, Zhang M, Troncoso P, Song JH, Lin SC, Song X, Liu J, Zhang J, Logothetis CJ, Melancon MP, Panaretakis T, Wang G, Lin SH. Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization. Proc Natl Acad Sci U S A 121(33):e2402903121, 2024. e-Pub 2024. PMID: 39102549.
- Melancon AD, Jacobsen M, Damasco J, Perez J, Bernardino M, Valentin ES, Court KA, Godin B, Layman R, Melancon MP. Correction for Partial Volume Averaging in the Quantification of Radiopaque Nanomaterial-Embedded Resorbable Polymers. Biomed Phys Eng Express 10(5), 2024. e-Pub 2024. PMID: 39094587.
- Lin SC, Yu G, Corn PG, Damasco J, Lee YC, Song JH, Navone NM, Logothetis CJ, Melancon MP, Panaretakis T, Lin SH. Radium-223 Treatment Produces Prolonged Suppression of Resident Osteoblasts and Decreased Bone Mineral Density in Trabecular Bone in Osteoblast Reporter Mice. Cancers (Basel) 16(14), 2024. e-Pub 2024. PMID: 39061241.
- Barcena AJR, Perez JVD, Bernardino MR, San Valentin EMD, Damasco JA, Klusman C, Martin B, Court KA, Godin B, Canlas G, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Controlled Delivery of Rosuvastatin or Rapamycin through Electrospun Bismuth Nanoparticle-Infused Perivascular Wraps Promotes Arteriovenous Fistula Maturation. ACS Appl Mater Interfaces 16(26):33159-33168, 2024. e-Pub 2024. PMID: 38912610.
- San Valentin EM, Damasco JA, Bernardino M, Court KA, Godin B, Canlas GM, Melancon A, Chintalapani G, Jacobsen MC, Norton W, Layman RR, Fowlkes N, Chen SR, Huang SY, Melancon MP. Image-guided deployment and monitoring of a novel tungsten nanoparticle-infused radiopaque absorbable inferior vena cava filter in a swine model. J Vasc Interv Radiol 35(1):113-121.e3, 2024. e-Pub 2024. PMID: 37696432.
- Klusman, C, Martin, B, Perez, JD, Barcena, AR, Bernardino, MR, Valentin, ED, Damasco, J, Del Mundo, HC, Court, KA, Godin, B, Canlas, GM, Fowlkes, NW, Bouchard, RR, Cheng, J, Huang, SY, Melancon, MP. Rosuvastatin-Eluting Gold-Nanoparticle-Loaded Perivascular Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model. Advanced Fiber Materials 5(6):1986-2001, 2023. e-Pub 2023.
- Barcena AJR, Perez JVD, Bernardino MR, Damasco JA, Cortes A, Del Mundo HC, San Valentin EMD, Klusman C, Canlas GM, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Bioresorbable Mesenchymal Stem Cell-Loaded Electrospun Polymeric Scaffold Inhibits Neointimal Hyperplasia Following Arteriovenous Fistula Formation in A Rat Model of Chronic Kidney Disease. Adv Healthc Mater 12(26):e2300960, 2023. e-Pub 2023. PMID: 37395729.
- Barcena AJR, Perez JVD, Damasco JA, Bernardino MR, San Valentin EMD, Klusman C, Martin B, Cortes A, Canlas GM, Del Mundo HC, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Gold Nanoparticles for Monitoring of Mesenchymal Stem-Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistula Maturation. Int J Mol Sci 24(14), 2023. e-Pub 2023. PMID: 37511512.
- Damasco JA, Yu G, Kumar A, Perez J, Lirag RCM, Whitley EM, Lin SH, Melancon MP. Alendronate conjugate for targeted delivery to bone-forming prostate cancer. Talanta 256:124308, 2023. e-Pub 2023. PMID: 36774896.
- Barcena AJR, Perez JVD, Damasco JA, Bernardino MR, San Valentin EMD, Klusman C, Martin B, Cortes A, Canlas G, Del Mundo HC, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas. bioRxiv, 2023. e-Pub 2023. PMID: 36778466.
- San Valentin EM, Damasco JA, Bernardino M, Court KA, Godin B, Canlas GM, Melancon A, Chintalapani G, Jacobsen MC, Norton W, Layman RR, Fowlkes N, Chen SR, Huang SY, Melancon MP. Image-guided deployment and monitoring of a novel tungsten nanoparticle–infused radiopaque absorbable inferior vena cava filter in pigs. bioRxiv, 2023. e-Pub 2023. PMID: 36798362.
- Klusman C, Martin B, Perez JVD, Barcena AJR, Bernardino MR, San Valentin EMD, Damasco JA, Mundo HCD, Court K, Godin B, Fowlkes N, Bouchard R, Cheng J, Huang SY, Melancon MP. Rosuvastatin-Eluting Gold Nanoparticle-Loaded Perivascular Implantable Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model. bioRxiv, 2023. e-Pub 2023. PMID: 36778365.
- Barcena AJR, Perez JVD, Liu O, Mu A, Heralde FM, Huang SY, Melancon MP. Localized perivascular therapeutic approaches to inhibit venous neointimal hyperplasia in arteriovenous fistula access for hemodialysis use. Biomolecules 12(10):1367, 2022. e-Pub 2022. PMID: 36291576.
- Rana MM, Melancon MP. Emerging Polymer Materials in Trackable Endovascular Embolization and Cell Delivery: From Hype to Hope. Biomimetics (Basel) 7(2):77, 2022. e-Pub 2022. PMID: 35735593.
- Damasco JA, Huang SY, Perez JVD, Manongdo JAT, Dixon KA, Williams ML, Jacobsen MC, Barbosa R, Canlas GM, Chintalapani G, Melancon AD, Layman RR, Fowlkes NW, Whitley EM, Melancon MP. Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs. ACS Biomater Sci Eng 8(4):1676-1685, 2022. e-Pub 2022. PMID: 35343679.
- Melancon MP, Yevich S, Avritscher R, Swigost A, Lu L, Tian L, Damasco JA, Dixon K, Cortes AC, Munoz NM, Liang D, Liu D, Tam AL. A Novel Lipiodol-Irinotecan Nanoemulsion for Intravascular Administration: Pharmacokinetics and Biodistribution in the Normal and Tumor Bearing Rat Liver. Drug Deliv 28(1):240-251, 2021. e-Pub 2021. PMID: 33501859.
- Vardaki I, Corn P, Gentile E, Song JH, Madan N, Hoang A, Parikh N, Guerra L, Lee YC, Lin SC, Yu G, Santos E, Melancon MP, Troncoso P, Navone N, Gallick GE, Efstathiou E, Subudhi SK, Lin SH, Logothetis CJ, Panaretakis T. Radium 223 treatment increase immune checkpoint expression in extracellular vesicles from the metastatic prostate cancer bone microenvironment. Clin Cancer Res 27(11):3253-3264, 2021. e-Pub 2021. PMID: 33753455.
- Hagaman DE, Damasco JA, Perez JVD, Rojo RD, Melancon MP. Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis. Molecules 26(2):384, 2021. e-Pub 2021. PMID: 33450939.
- Perez JVD, Jacobsen MC, Damasco JA, Melancon A, Huang SY, Layman RR, Melancon MP. Optimization of the differentiation and quantification of high Z nanoparticles incorporated in medical devices for CT-guided interventions. Med Phys 48(1):300-312, 2021. e-Pub 2021. PMID: 33216978.
- Rojo RD, Perez JVD, Damasco JA, Yu G, Lin SC, Heralde FM, Novone NM, Santos EB, Lin SH, Melancon MP. Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice. Int J Hyperthermia 38(1):650-662, 2021. e-Pub 2021. PMID: 33882773.
- Perez JD, Singhana S, Damasco J, Lu L, Behlau P, Rojo R, Whitley E, Heralde F, Melancon A, Huang S, Melancon MP. Radiopaque scaffolds based on electrospun iodixanol/polycaprolactone nanofibrous composites. Materialia 14:100874, 2020. e-Pub 2020.
- Perez JVD, Singhana B, Damasco J, Lu L, Behlau P, Rojo RD, Whitley EM, Heralde F, Melancon A, Huang S, Melancon MP. Radiopaque scaffolds based on electrospun iodixanol/polycaprolactone fibrous composites. Materialia (Oxf) 14, 2020. e-Pub 2020. PMID: 32954230.
- Huang SY, Damasco JA, Tian L, Lu L, Perez JVD, Dixon KA, Williams ML, Jacobsen MC, Dria SJ, Eggers MD, Melancon AD, Layman RR, Whitley EM, Melancon MP. In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model. Biomater Sci 8(14):3966-3978, 2020. e-Pub 2020. PMID: 32558854.
- Sheth RA, Wen X, Li J, Melancon MP, Ji X, Wang A, Hsiao C, Chow D, Whitley E, Li C, Gupta S. Doxorubicin‑loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy. Cancer Nanotechnology 11(6):1635, 2020. e-Pub 2020.
- Avritscher R, Jo N, Polak U, Cortes AC, Nishiofuku H, Odisio BC, Takaki H, Tam AL, Melancon MP, Yevich S, Qayyum A, Kaseb A, Kichikawa K, Gupta S, Goldberg SN, Chang SH. Hepatic arterial bland embolization increases Th17 cell infiltration in a syngeneic rat model of hepatocellular carcinoma. Cardiovasc Intervent Radiol 43(2):311-321, 2020. e-Pub 2020. PMID: 31591689.
- Lin M, Paolillo V, Ta RT, Damasco J, Rojo RD, Carl JC, Melancon MP, Ravizzini GC, Le DB, Santos EB. Fully Automated Preparation of 68Ga-PSMA-11 at Curie Level Quantity Using Cyclotron-Produced 68Ga for Clinical Applications. Appl Radiat Isot 155:108936, 2020. e-Pub 2020. PMID: 31655351.
- Sheth RA, Wen X, Li J, Melancon MP, Ji X, Wang YA, Hsiao CH, Chow DS, Whitley EM, Li C, Gupta S. Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy. Cancer Nanotechnol 11(1), 2020. e-Pub 2020. PMID: 34335988.
- Tian L, Wang L, Qiao Y, Lu L, Lee P, Chang A, Ravi S, Rogers TA, Melancon MP. Antitumor efficacy of liposome-encapsulated NVP-BEZ235 combined with irreversible electroporation for head and neck cancer. Molecules 24(19):3560, 2019. e-Pub 2019. PMID: 31581445.
- Zhao J, Wen X, Tian L, Li T, Xu C, Wen X, Melancon MP, Gupta S, Shen B, Peng W, Li C. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nat Commun 10(899):1-14, 2019. e-Pub 2019. PMID: 30796212.
- Tian L, Qiao Y, Lee P, Wang L, Chang A, Ravi S, Rogers TA, Lu L, Singhana B, Zhao J, Melancon MP. Antitumor efficacy of liposome-encapsulated NVP-BEZ 235 in combination with irreversible electroporation. Drug Deliv 25(1):668-678, 2018. e-Pub 2018. PMID: 29482386.
- Qiao Y, Gumin J, MacLellan CJ, Gao F, Bouchard R, Lang FF, Stafford RJ, Melancon MP. Magnetic resonance and photoacoustic imaging for treatment planning of brain tumor mediated by mesenchymal stem cell-labeled with multifunctional nanoparticle. Nanotechnology 29(16):165101, 2018. e-Pub 2018. PMID: 29438105.
- Melancon MP, Appleton Figueira T, Fuentes DT, Tian L, Qiao Y, Gu J, Gagea M, Ensor JE, Muñoz NM, Maldonado KL, Dixon K, McWatters A, Mitchell J, McArthur M, Gupta S, Tam AL. Development of an Electroporation and Nanoparticle-based Therapeutic Platform for Bone Metastases. Radiology 286(1):161721, 2018. e-Pub 2018. PMID: 28825892.
- Cao Q, Yan X, Chen K, Huang Q, Melancon MP, Lopez G, Cheng Z, Li C. Macrophages as a Potential Tumor-Microenvironment Target for Noninvasive Imaging of Early Response to Anticancer Therapy. Biomaterials 152:63-76, 2018. e-Pub 2018. PMID: 29111494.
- Huang SY, Eggers M, McArthur MJ, Dixon KA, McWatters A, Dria S, Hill LR, Melancon MP, Steele JR, Wallace MJ. Safety and Efficacy of an Absorbable Filter in the Inferior Vena Cava to Prevent Pulmonary Embolism in Swine. Radiology 285(3):161880, 2017. e-Pub 2017. PMID: 28708470.
- Tian L, Lee P, Singhana B, Chen A, Qiao Y, Lu L, Martinez JO, Tasciotti E, Melancon A, Huang S, Eggers M, Melancon MP. Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles. Sci Rep 7(1):2147, 2017. e-Pub 2017. PMID: 28526874.
- Tian L, Chang A, Melancon MP. Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems. Transl Cancer Res 6(Suppl 2):S309-S312, 2017. e-Pub 2017. PMID: 28690978.
- Zhou M, Melancon MP, Stafford RJ, Li J, Nick AM, Tian M, Sood AK, Li C. Precision Nanomedicine Using Dual Positron Emission Tomography and Magnetic Resonance Temperature Imaging-Guided Photothermal Therapy. J Nucl Med 57(11):1778-1783, 2016. e-Pub 2016. PMID: 27283932.
- Hosoya H, Dobroff AS, Driessen WH, Cristini V, Brinker LM, Staquicini FI, Cardó-Vila M, D'Angelo S, Ferrara F, Proneth B, Lin YS, Dunphy DR, Dogra P, Melancon MP, Stafford RJ, Miyazono K, Gelovani JG, Kataoka K, Brinker CJ, Sidman RL, Arap W, Pasqualini R. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release. Proc Natl Acad Sci U S A 113(7):1877-82, 2016. e-Pub 2016. PMID: 26839407.
- Tam AL, Melancon MP, Abdelsalam M, Figueira TA, Dixon K, McWatters A, Zhou M, Huang Q, Mawlawi O, Dunner K, Li C, Gupta S. Imaging Intratumoral Nanoparticle Uptake after Combining Nanoembolization with Various Ablative Therapies in Hepatic VX2 Rabbit Tumors. J Biomed Nanotechnol 12(2):296-307, 2016. e-Pub 2016. PMID: 27305763.
- Zhao J, Lee P, Wallace MJ, Melancon MP. Gold Nanoparticles in Cancer Therapy: Efficacy, Biodistribution, and Toxicity. Curr Pharm Des 21(29):4240-51, 2015. e-Pub 2015. PMID: 26323426.
- Zhao J, Qiao J, Zhou M, Gupta S, Li C, Melancon MP. Anti-tumor Efficacy Study using Irreversible Electroporation and Doxorubicin-loaded Polymeric Micelles. ACS Macro Lett 4(10):1081-1084, 2015. e-Pub 2015. PMID: 28529822.
- Mitcham T, Dextraze K, Taghavi H, Melancon M, Bouchard R. Photoacoustic imaging driven by an interstitial irradiation source. Photoacoustics 3(2):45-54, 2015. e-Pub 2015. PMID: 26236640.
- Zhao J, Melancon MP, Zhou M. Nanoparticle Formulation to Improve the Efficacy of Radiation Therapy Against Radiation-Resistant Leukemia. EBioMedicine 2(6):486, 2015. e-Pub 2015. PMID: 26288809.
- Singhana B, Chen A, Slattery P, Yazdi IK, Qiao Y, Tasciotti E, Wallace M, Huang S, Eggers M, Melancon MP. Infusion of Iodine-Based Contrast Agents into Poly(p-dioxanone) as a Radiopaque Resorbable IVC Filter. J Mater Sci Mater Med 26(3):124, 2015. e-Pub 2015. PMID: 25690619.
- Tam AL, Melancon MP, Ensor J, Liu Y, Dixon K, McWatters A, Gupta S. Rabbit Hepatic Arterial Anatomy Variations: Implications on Experimental Design. Acta Radiol 55(10):1226-33, 2014. e-Pub 2014. PMID: 24292899.
- Zhao J, Vykoukal J, Abdelsalam M, Recio-Boiles A, Huang Q, Qiao Y, Singhana B, Wallace M, Avritscher R, Melancon MP. Stem cell-mediated delivery of SPIO-loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma. Nanotechnology 25(40):405101, 2014. e-Pub 2014. PMID: 25211057.
- Zhao J, Wallace M, Melancon MP. Cancer Theranostics with Gold Nanoshells. Nanomedicine (Lond) 9(13):2041-57, 2014. e-Pub 2014. PMID: 25343352.
- Singhana B, Slattery P, Chen A, Wallace MJ, Melancon MP. Light-Activatable Gold Nanoshells for Drug Delivery Applications. AAPS PharmSciTech 15(3):741-52, 2014. e-Pub 2014. PMID: 24550102.
- Melancon MP, Zhou M, Zhang R, Xiong C, Allen P, Wen X, Huang Q, Wallace M, Myers JN, Stafford RJ, Liang D, Ellington AD, Li C. Selective Uptake and Imaging of Aptamer- and Antibody-Conjugated Hollow Nanospheres Targeted to Epidermal Growth Factor Receptors Overexpressed in Head and Neck Cancer. ACS Nano 8(5):4532-8, 2014. e-Pub 2014. PMID: 24754567.
- Zhou M, Singhana B, Liu Y, Huang Q, Mitcham T, Wallace MJ, Stafford RJ, Bouchard RR, Melancon MP. Photoacoustic- and Magnetic Resonance-Guided Photothermal Therapy and Tumor Vasculature Visualization Using Theranostic Magnetic Gold Nanoshells. J Biomed Nanotechnol 11(8):1385-1400, 2014. e-Pub 2014. PMID: 26295144.
- Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace MJ, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with Doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Control Release 172(1):152-158, 2013. e-Pub 2013. PMID: 23920038.
- Melancon MP, Stafford RJ, Li C. Challenges to effective cancer nanotheranostics. J Control Release 164(2):177-82, 2012. e-Pub 2012. PMID: 22906841.
- You J, Zhang R, Xiong C, Zhong M, Melancon MP, Gupta S, Nick AM, Sood AK, Li C. Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors. Cancer Res 72(18):4777-4786, 2012. e-Pub 2012. PMID: 22865457.
- Zhang G, Zhang R, Melancon MP, Wong K, You J, Huang Q, Bankson J, Liang D, Li C. The degradation and clearance of Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent. Biomaterials 33(21):5376-83, 2012. e-Pub 2012. PMID: 22541356.
- Melancon MP, Elliott AM, Shetty A, Huang Q, Stafford RJ, Li C. Near-infrared light modulated photothermal effect increases vascular perfusion and enhances polymeric drug delivery. J Control Release 156(2):265-72, 2011. e-Pub 2011. PMID: 21763373.
- Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer. Biomaterials 32(30):7600-8, 2011. e-Pub 2011. PMID: 21745689.
- Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Song S, Zhang R, Flores LG, Gelovani JG, Wang LV, Ku G, Stafford RJ, Li C. Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res 71(19):6116-21, 2011. e-Pub 2011. PMID: 21856744.
- Melancon MP, Zhou M, Li C. Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles. Acc Chem Res 44(10):947-956, 2011. e-Pub 2011. PMID: 21848277.
- Melancon MP, Elliott A, Ji X, Shetty A, Yang Z, Tian M, Taylor B, Stafford RJ, Li C. Theranostics with multifunctional magnetic gold nanoshells: photothermal therapy and t2* magnetic resonance imaging. Invest Radiol 46(2):132-40, 2011. e-Pub 2011. PMID: 21150791.
- Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C. A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc 132(43):15351-8, 2010. e-Pub 2010. PMID: 20942456.
- Melancon MP, Lu W, Huang Q, Thapa P, Zhou D, Ng C, Li C. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. Biomaterials 31(25):6567-73, 2010. e-Pub 2010. PMID: 20537382.
- Melancon MP, Lu W, Li C. Gold-Based Magneto/Optical Nanostructures: Challenges for In Vivo Applications in Cancer Diagnostics and Therapy. Mater Res Bull 34(6):415-421, 2009. e-Pub 2009. PMID: 20582234.
- Stafford RJ, Shetty A, Elliott AM, Scwartz J, Melancon MP, Li C, Hazle JD. Characterization of Gold Nanoshells for Thermal Therapy Using MRI. Medical Physics 35(6):2937-2938, 2008. e-Pub 2008.
- Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, Stafford J, Olson T, Zhang JZ, Li C. In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther 7(6):1730-9, 2008. e-Pub 2008. PMID: 18566244.
- Melancon MP, Wang Y, Wen X, Bankson JA, Stephens LC, Jasser S, Gelovani JG, Myers JN, Li C. Development of a macromolecular dual-modality MR-optical imaging for sentinel lymph node mapping. Invest Radiol 42(8):569-78, 2007. e-Pub 2007. PMID: 17620940.
- Melancon MP, Wang W, Wang Y, Shao R, Ji X, Gelovani JG, Li C. A novel method for imaging in vivo degradation of poly(L-glutamic acid), a biodegradable drug carrier. Pharm Res 24(6):1217-24, 2007. e-Pub 2007. PMID: 17377742.
- Wang W, Wu Q, Pasuelo MJ, McMurray JS, Li C. Probing for integrin alpha v beta3 binding of RGD peptides using fluorescence polarization. Bioconjug Chem 16(3):729-34, 2005. e-Pub 2005. PMID: 15898744.
- Tansey W, Ke S, Cao XY, Pasuelo MJ, Wallace S, Li C. Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier. J Control Release 94(1):39-51, 2004. e-Pub 2004. PMID: 14684270.
- Pasuelo MJ, Dayrit FM. Development of quality assurance methods for medicinal plants using gas chromatography analysis. Kimika 17:5-11, 2001. e-Pub 2001.
- Melancon AD, Jacobsen M, Damasco JA, Perez JD, Bernardino MR, San Valentin E, Court KA, Godin B, Layman RR, Melancon MP. Correction Factors for Partial Volume Averaging in the Quantification of Radiopaque Nanomaterial-Embedded Resorbable Polymers. Physics in Medicine and Biology.
- Barcena A, Perez JD, Bernardino M, Damasco J, Valentin ES, Mundo HD, Fowlkes N, Chen J, Huang S, Melancon M. Ultrasound and Photoacoustic Imaging of Bioresorbable Mesenchymal Stem Cell-Loaded Scaffold to Improve Rates of Arteriovenous Fistula Maturation and Long-Term Patency. Polymers.
Other Articles
- Barcena AJR, Mishra A, Bolinas DKM, Martin BM, Melancon MP Integration of Electrospun Scaffolds and Biological Polymers for Enhancing the Delivery and Efficacy of Mesenchymal Stem/Stromal Cell Therapies. Front Biosci (Landmark Ed) 29(6):228, 2024. PMID: 38940050.
- San Valentin EMD, Barcena AJR, Klusman C, Martin B, Melancon MP Nano-embedded medical devices and delivery systems in interventional radiology. Wiley Interdiscip Rev Nanomed Nanobiotechnol 15(1):e1841, 2023. PMID: 35946543.
- Damasco JA, Ravi S, Perez JD, Hagaman DE, Melancon MP Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine. Nanomaterials (Basel) 10(11), 2020. PMID: 33147800.
- Tian L, Lu L, Feng J, Melancon MP Radiopaque nano and polymeric materials for atherosclerosis imaging, embolisation and other catheterization procedures. Acta Pharm Sin B 8(3):360-370, 2018. PMID: 29881675.
- Tian L, Lu L, Qiao Y, Ravi S, Salatan F, Melancon MP Stimuli-responsive gold nanoparticles for cancer diagnosis and therapy. J Funct Biomater 7(3), 2016. PMID: 27455336.
- Melancon MP, Li C Multifunctional synthetic polymer-based therapeutic and diagnostic agents. Mol Imaging 10(1):28-42, 2011. PMID: 21303613.
- Wen X, Cao X, Pasuelo MJ, Wendt R, Li C Polymeric radiotracers in nuclear imaging. Curr Drug Deliv 1(4):377-84, 2004. PMID: 16305399.
Abstracts
- Melancon A, Jacobsen M, Salatan F, Jones A, Cody D, Nute J, Pasuelo MJ. SU-F-207-07: Dual-Energy Computed Tomography Detection Limit of Various Radiopaque Contrast Agents That Can Be Infused Within Absorbable Inferior Vena Cava Filters. Med Phys 42(6):3543, 2015. e-Pub 2015. PMID: 26128553.
- MacLellan CJ, Melancon MJ, Salatan F, Yang Q, Hwang KP, Fuentes D, Stafford RJ. MO-FG-BRA-09: Quantification of Nanoparticle Heating and Concentration for MR-Guided Laser Interstitial Thermal Therapy. Med Phys 42(6):3566, 2015. e-Pub 2015. PMID: 26128712.
Book Chapters
- Tian L, Lu L, Melancon MP. Gold Nanoparticles in Cancer Therapy. In: Handbook of Materials for Nanomedicine. 1st. Pan Stanford Publishers, 2020.
- Singhana B, Slattery P, Melancon MP. Targeted Gold Nanoshells. In: Applications of Nanoscience in Photomedicine. 1st. Woodhead Publishing Limited, 2015.
- Lu W, Melancon MP, Li C. Theranostic Applications of Gold Core-Shell Structured Nanoparticles. In: Nanoplatform-based Molecular Imaging. John Wiley & Sons Publishing, 683-708, 2011.
- Melancon MP, Wen X, Zhang G, Li C. Multifunctional, multimodality cancer imaging with water-soluble synthetic polymer nanoparticles. In: Nanoimaging. Pan Stanford Publishing Pte Ltd, 171-195, 2010.
- Melancon MP, Li C. Core-shell magnetic nanomaterials for medical diagnosis and therapy. In: Magnetic Nanomaterials. Wiley-VCH, 259-290, 2009.
Grant & Contract Support
| Date: | 2024 - 2025 |
| Title: | Computational and Preclinical Modeling to Predict Liver Growth in Patients with Liver Malignancy Undergoing Portal Vein Blockade |
| Funding Source: | Joint Center for Computational Oncology |
| Role: | PI |
| Date: | 2024 - 2027 |
| Title: | Development of Radiopaque, Drug-Eluting, Bioresorbable Vascular Grafts |
| Funding Source: | American Heart Association |
| Role: | PI |
| ID: | 24TPA1280217 |
| Date: | 2024 - 2029 |
| Title: | Endothelial Dysfunction Deteriorates Arteriovenous Fistula Maturation Failure |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Nanoparticle-Infused Radiopaque Medical Device |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| Date: | 2024 - 2029 |
| Title: | Mesenchymal Stem Cell-Loaded Biopolymeric Scaffolds for Augmenting the Preoperative Liver Growth |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA293481-01 |
| Date: | 2023 - 2031 |
| Title: | Nanoparticle-Enhanced Absorbable Medical Devices for Management of Vascular Diseases |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1-R35-HL171336-01 |
| Date: | 2023 - 2028 |
| Title: | Medical Students Summer in Oncology at Anderson Research (Med Students SOAR) program |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1 R25 CA265800-01A1 |
| Date: | 2023 - 2023 |
| Title: | Middle School Camp in Oncology at MD Anderson (MS-COMDA) |
| Funding Source: | Texas Workforce Commission - Governor’s Summer Merit Program |
| Role: | PI |
| ID: | 2823SMP003 |
| Date: | 2022 - 2026 |
| Title: | Biodegradable Radiopaque Polymeric Scaffolds Loaded with Mesenchymal Stem Cells for Image-Guided Arteriovenous Fistula Maturation and Long-Term Patency |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1-R01-HL159960-01A1-01 |
| Date: | 2021 - 2023 |
| Title: | Center for Advanced Biomedical Imaging Pilot Project Program Grant |
| Funding Source: | MD Anderson Cancer Center |
| Role: | Co-PI |
| Date: | 2021 - 2024 |
| Title: | Nanoparticle-Infused Radiopaque Absorbable Medical Device |
| Funding Source: | MD Anderson Cancer Center |
| Role: | PI |
| ID: | Adverse Incident Bridge Funding Program |
| Date: | 2021 - 2023 |
| Title: | Development of a resorbable radiopaque rosuvastatin-eluting polymer to improve rates of arteriovenous fistula maturation and long-term patency for patients on hemodialysis |
| Funding Source: | Society for Interventional Radiology |
| Role: | Co-I |
| Date: | 2020 - 2021 |
| Title: | Development of a Bioresorbable Mesenchymal Stem Cell-loaded Radiopaque Polymer to Improve Rates of Arteriovenous Fistula Maturation and Long-term Patency |
| Funding Source: | Radiological Society of North America (RSNA) |
| Role: | Co-I |
| Date: | 2019 - 2022 |
| Title: | Bone-specific delivery of palovarotene for prostate cancer bone metastasis treatment |
| Funding Source: | MD Anderson Cancer Center |
| Role: | PI |
| ID: | Institutional Research Grant |
| Date: | 2018 - 2023 |
| Title: | Endothelial-to-osteoblast transition in prostate cancer bone metastasis |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 5-R01-CA174798-06 |
| Date: | 2018 - 2024 |
| Title: | Nanoparticle-Infused Radiopaque Absorbable Medical Device |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 5-R01-HL141831-05 |
| Date: | 2017 - 2019 |
| Title: | Drug Release and Pharmacokinetic after chemoembolization using Irinotican (IRI)- loaded lipiodol Emulsions and drug eluting beads in a rat tumor model |
| Funding Source: | Guerbet |
| Role: | Co-I |
| Date: | 2017 - 2019 |
| Title: | Transportal Irinotecan Chemoembolization using a Lipiodol Nano-emulsion (TICL) for the Treatment of Colorectal Liver Metastases in Rat |
| Funding Source: | Radiological Society of North America (RSNA) |
| Role: | Collaborator |
| Date: | 2017 - 2018 |
| Title: | Transportal Irinotecan Chemoembolization using a Lipiodol Nano-emulsion (TICL) for the Treatment of Colorectal Liver Metastases in Rat |
| Funding Source: | Society of Interventional Radiology |
| Role: | Collaborator |
| Date: | 2016 - 2018 |
| Title: | Nanoparticle-Infused Radiopaque Absorbable Medical Device |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1 R56 HL131633-01 |
| Date: | 2015 - 2016 |
| Title: | Low Cost Nanoparticle Platform for Diagnosis and Treatment of Colorectal Liver Metastases |
| Funding Source: | Canadian Radiological Foundation |
| Role: | Co-I |
| Date: | 2015 - 2018 |
| Title: | Radiopaque absorbable inferior vena cava filter for dual-energy computed tomography |
| Funding Source: | American Heart Association |
| Role: | PI |
| Date: | 2015 - 2016 |
| Title: | Radiopaque enhancement of absorbable IVC filters mediated by gold nano particles using dual-energy computed tomography |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | IRG |
| Date: | 2014 - 2015 |
| Title: | Developing an electroporation and nanoparticle-based therapeutic platform for bone metastases: evaluation of local delivery strategies to optimize intratumoral nanoparticle uptake |
| Funding Source: | Radiological Society of North America (RSNA) |
| Role: | Collaborator |
| Date: | 2014 - 2015 |
| Title: | Visual and Functional Characterization of Nanopore Formation after Irreversible Electroporation (IRE) in the Porcine Vertebral Body |
| Funding Source: | Society of Interventional Radiology Foundation |
| Role: | Collaborator |
| Date: | 2014 - 2015 |
| Title: | Molecular Imaging Strategy for Treatment Planning of Brain Tumor Mediated by Stem Cells Labeled with Multifunctional Nanoparticle |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator - CDA |
| ID: | 2P50CA127001-06 |
| Date: | 2012 - 2020 |
| Title: | Development of Theranostic Agents for Cancer |
| Funding Source: | MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2012 - 2014 |
| Title: | Real-Time Assessment of Enhanced Permeability and Retention Dynamics in Tumors Using Magnetic Nanoparticles |
| Funding Source: | NIH/NCI |
| Role: | Investigator |
| ID: | SBIR |
| Date: | 2010 - 2011 |
| Title: | Targeted Nanoshell-based Agent for MRI-Guided Thermal Ablation of Recurrent Head and Neck Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator - CDA |
| ID: | P50CA097007 |
| Date: | 2009 - 2012 |
| Title: | MRI-Guided Thermal Ablation Mediated by Multifunctional Gold-Based Nanoshells |
| Funding Source: | Odyssey Program |
| Role: | PI |
Patient Reviews
CV information above last modified April 02, 2025