Mary Guirguis, M.D.
Department of Breast Imaging, Division of Diagnostic Imaging
About Dr. Mary Guirguis
Dr. Guirguis is a faculty member in the department of breast imaging. She is passionate about clinical service and trainee education. Her clinical and research interests include breast conservation therapy, triple negative breast cancer, preoperative localization, digital breast tomosynthesis, and breast MRI.
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Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Breast Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Breast Conservation Therapy
Preoperative Localization
Triple Negative Breast Cancer
Breast MRI
Clinical Interests
Resident and fellow education
Digital Breast Tomosynthesis
Preoperative localization
Education & Training
Degree-Granting Education
| 2013 | The University of Texas Medical School at Houston (McGovern Medical School), Houston, Texas, US, MD |
| 2009 | University of Houston, Houston, Texas, US, German, BA |
| 2009 | University of Houston, Houston, Texas, US, Biology, BS |
Postgraduate Training
| 2018-2019 | Clinical Fellowship, Breast and Body Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2017-2017 | Healthcare Management Certificate, University of Houston Clear Lake, Houston, Texas |
| 2014-2018 | Clinical Residency, Diagnostic Radiology, The University of Texas Medical School at Houston (McGovern Medical School), Houston, Texas |
| 2013-2014 | Clinical Internship, Internal Medicine, Presbyterian Hospital Dallas, Dallas, Texas |
Board Certifications
| 2019 | American Board of Radiology |
Experience & Service
Academic Appointments
Assistant Professor, Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2024
Assistant Professor, Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2019
Other Appointments/Responsibilities
Residency Interviewer, Diagnostic Radiology Residency, McGovern Medical School, Houston, TX, 2023 - Present
Board Member, Friends of Egyptian Children with Cancer, Houston, TX, 2022 - Present
Secretary, St. Paul American Coptic Orthodox Church, Houston, TX, 2014 - 2022
Selected Publications
Abstracts
- Le-Petross, HT, Son, JB, Ma, J, Whitman, GJ, Guirguis, MS, Patel, MM, Kapoor, MM, Sun, SX, Lim, B, Alexander, A, Lucci, A, Woodward, WA. Quantitative diffusion weighted imaging for predicting response to neoadjuvant therapy in patients with inflammatory breast cancer. San Antonio Breast Cancer Symposium, 2024. e-Pub 2024.
- Mohamed RM, Panthi B, Adrada BE, Candelaria RP, Guirguis MS, Yang W, Boge M, Patel MM, Elshafeey NA, Pashapoor S, Zhou Z, Son JB, Hwang KP, Le-Petross HC, Leung J, Scoggins ME, Whitman GJ, Xu Z, Lane DL, Moseley T, Perez F, White JB, Ravenberg EE, Clayborn AR, Pagel MD, Chen H, Sun J, Wei P, Thompson A, Moulder S, Korkut A, Huo L, Hunt K, Litton J, Valero V, Tripathy D, Yam C, Ma J, Rauch GM. Multi-parametric MRI-based radiomics models from tumor and peritumoral regions as potential predictors of treatment response to neoadjuvant systemic therapy in triple negative breast cancer patients. Cancer Res 83(5):P6-01-06, 2023. e-Pub 2023.
- Panthi B, Mohamed RM, Adrada BE, Candelaria RP, Guirguis MS, Yang W, Boge M, Patel MM, Elshafeey NA, Pashapoor S, Zhou Z, Son JB, Hwang KP, Le-Petross HC, Leung J, Scoggins ME, Whitman GJ, Xu Z, Lane DL, Moseley T, Perez F, White JB, Ravenberg EE, Clayborn AR, Pagel MD, Chen H, Sun J, Wei P, Thompson A, Moulder S, Korkut A, Huo L, Hunt K, Litton J, Valero V, Tripathy D, Yam C, Ma J, Rauch GM. Longitudinal DCE-MRI radiomic models for early prediction of response to neoadjuvant systemic therapy (NAST) in triple negative breast cancer (TNBC) patients. Cancer Res 83(5):P6-01-34, 2023. e-Pub 2023.
- Guirguis MS, Adrada B, Patel M, Perez F, Candelaria R, Yang W, Sun J, Mohamed RM, Boge M, Le-Petross HTC, Leung J, Whitman GJ, Lane DL, Scoggins ME, Moseley T, White J, Wei P, Son JB, K-P H, Panthi B, Pagel M, Hunt KK, Thompson AM, Litton JK, Valero V, Tripathy D, Yam C, Ma J, Rauch G. DCE-MRI for early prediction of excellent response versus chemoresistance in triple negative breast cancer. Cancer Res 83(5):P1-05-15, 2023. e-Pub 2023.
- Mohamed RM, Panthi B, Adrada B, Candelaria R, Guirguis MS, Yang W, Boge M, Patel M, Elshafeey N, Pashapoor S, Zhou Z, Son JB, Hwang KP, Le-Petross HT, Leung J, Scoggins ME, Whitman GJ, Xu Z, Lane DL, Moseley T, Perez F, White J, Chen H, Sun J, Wei P, Litton JK, Valero V, Yam C, Pagel M, Ma J, Rauch GM. A pre-operative dynamic contrast enhanced MRI-based radiomics models as predictors of treatment response after neoadjuvant systemic therapy in triple negative breast cancer patients. Cancer Res 83(5):1307535, 2023. e-Pub 2023.
- Zhou Z, Elshafeey NA, Rauch DE, Adrada BE, Candelaria RP, Guirguis MS, Yang W, Boge M, Mohamed RM, Whitman GJ, Lane DL, Le-Petross HC, Leung JWT, Santiago L, Scoggins ME, Spak DA, Patel MM, Perez F, Tripathy D, Valero V, Yam C, Moulder S, White JB, Son JB, Pagel MD, Rauch GM, Ma J. Deep learning for early prediction of neoadjuvant chemotherapy response in triple negative breast cancers. Cancer Res 82(4):P1-08-03, 2022. e-Pub 2022.
- Rauch GM, Candelaria RP, Guirguis MS, Boge M, Mohamed RMM, Elshafeey N, Sun J, Whitman GJ, Leung J, Le-Petross HC, Santiago L, Lane D, Scoggins M, Spak D, Patel MM, Perez F, White JB, Ravenberg E, Peng W, Tripathy D, Valero V, Litton J, Huo L, Yam C, Thompson A, Ma J, Moulder SL, Yang W, Adrada BE. Integrated model for early prediction of neoadjuvant systemic therapy response in triple negative breast cancer. Cancer Res 82(4):PD11-07, 2022. e-Pub 2022.
- Guirguis MS, Adrada BE, Candelaria RP, Sun J, Whitman GJ, Yang WT, Boge M, Mohamed RM, Elshafeey NA, Lane DL, Le-Petross H, Leung JWT, Santiago L, Scoggins ME, Spak DA, Patel M, Perez F, Wei P, Tripathy D, White J, Ravenberg E, Huo L, Litton J, Arun B, Valero V, Thompson A, Moulder S, Yam C, Rauch GM. Prediction of response to neoadjuvant systemic therapy in triple negative breast cancer using baseline tumor MRI characteristics and imaging patterns of response. Cancer Res 82(4):P3-03-06, 2022. e-Pub 2022.
- Elshafeey N, Hwang KP, Adrada BE, Candelaria RP, Boge M, Mahmoud RM, Chen H, Sun J, Yang W, Kotrotsou A, Musall BC, Son JB, Whitman GJ, Leung J, Le-Petross H, Santiago L, Lane DL, Scoggins ME, Spak DA, Guirguis MS, Patel MM, Perez F, Abdelhafez AH, White JB, Hu L, Ravenberg E, Peng W, Thompson A, Damodaran S, Tripathy D, Moulder SL, Yam C, Pagel MD, Ma J, Rauch GM. Radiomics model based on magnetic resonance image compilation (MagIC) as early predictor of pathologic complete response to neoadjuvant systemic therapy in triple-negative breast cancer. Cancer Res 82(4):PD11-06, 2022. e-Pub 2022.
- Guirguis MS, Beckmann N. Traumatic scapula fractures: A review of classifications and management. Emerg Radiol(29):219-225, 2018. e-Pub 2018.
- Guirguis MS, Ko A, Chinapuvvula NR. Imaging of acute pelvic pain in the premenopausal female: How to ensure timely surgical management. Emerg Radiol(22):457-510, 2016. e-Pub 2016.
Book Chapters
- Rauch GM, Guirguis MS, Adrada BE. After breast conservation therapy. In: CORE Requisites: Breast Imaging. Elsevier, 2022.
Selected Presentations & Talks
National Presentations
- 2024. Beyond metastatic lymphadenopathy in breast cancer: An approach to axillary masses". Conference. 110th Scientific Assembly and Annual Meeting of the Radiological Society of North America. Chicago, IL, US.
- 2024. Less is more: De-escalation of surgery on the breast and axilla - The role of imaging. Conference. 110th Scientific Assembly and Annual Meeting of the Radiological Society of North America. Chicago, IL, US.
- 2024. Breast Imaging of patients with LI-Fraumeni Syndrome with updated review of breast screening guidelines. Conference. Radiological Society of North America 110th Scientific Assembly and Annual Meeting. Chicago, ILL, US.
- 2024. Unraveling the complexity of breast masses with associated necrosis: Significance and management. Conference. 110th Scientific Assembly and Annual Meeting of the Radiological Society of North America. Chicago, IL, US.
- 2024. Chosen: The impact of breast biopsy marker (clip) selection on breast imaging procedures, follow-up, and cost. Conference. 110th Scientific Assembly and Annual Meeting of the Radiological Society of North America. Chicago, IL, US.
- 2024. Basics of Image Guided Localization. Conference. American Roentgen Ray Society (virtual), US.
- 2024. Challenging Cases and Troubleshooting - Stereotactic-Guided Breast Biopsies. Conference. American Roentgen Ray Society Annual Meeting. Boston, MA, US.
- 2023. More than just gynecomastia: Spectrum of male breast pathologies (presentation). Conference. Society of Breast Imaging/American College of Radiology Breast Imaging Symposium. National Harbor, MD, US.
- 2023. Gadgets and gizmos a-plenty: Foreign bodies encountered in breast imaging (educational exhibit). Conference. Society of Breast Imaging/American College of Radiology Breast Imaging Symposium. National Harbor, MD, US.
- 2023. Radiology Review Track: Breast Imaging: Rapid Fire Case Review: Architectural Distortion. Invited. American Roentgen Ray Society 123rd Annual Meeting. Honolulu, HI, US.
- 2023. Management of bleeding complications after image guided breast biopsy: A case-based review. Conference. American Roentgen Ray Society 123rd Annual Meeting. Honolulu, HI, US.
- 2022. Longitudinal DCE-MRI radiomic models for early prediction of response to neoadjuvant systemic therapy (NAST) in triple negative breast cancer (TNBC) patients (scientific poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2022. Multi-parametric MRI-based radiomics models from tumor and peritumoral regions as potential predictors of treatment response to neoadjuvant systemic therapy in triple negative breast cancer patients (scientific poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2022. DCE-MRI for early prediction of excellent response versus chemoresistance in triple negative breast cancer (scientific poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2022. A pre-operative dynamic contrast enhanced MRI-based radiomics models as predictors of treatment response after neoadjuvant systemic therapy in triple negative breast cancer patients (scientific poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2022. Comparing the performance of full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) in the post-treatment surveillance of patients with a history of breast cancer: A retrospective study. Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. Multi-parametric MRI-based radiomics models for early neoadjuvant systemic treatment response prediction in triple negative breast cancer (TNBC). Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. Development of a combined model for early prediction of pathologic complete response (pCR) in triple negative breast cancer (TNBC) undergoing neoadjuvant therapy (NAT). Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. Deep learning using pre-treatment MRIs and clinical information for prediction of pathologic complete response to neoadjuvant systemic therapy in triple negative breast cancer. Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. Early prediction of chemoresistance versus excellent response in triple negative breast cancer patients with DCE-MRI. Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. A comprehensive look at disparities in breast cancer in the non-Hispanic Black, Hispanic, and transgender community and what policy changes should be considered (educational exhibit). Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. All roads lead to Rome: Multi-modality imaging of benign and malignant pathologies of the nipple areolar complex (educational exhibit). Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. The many faces of triple negative breast cancer (educational exhibit). Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. Breast cancer recurrence: Multi-modality imaging in patients undergoing breast conservation treatment (educational exhibit). Conference. 108th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2022. Moving beyond alphabet soup using root cause analysis (RCA) and failure mode and effects analysis (FMEA) to learn from errors in the breast imaging clinic. Conference. Radiological Society of North America 108th Annual Meeting Program. Chicago, IL, US.
- 2022. A case of mistaken identity: Differentiating benign and malignant lymph nodes in breast cancer patients in the setting of COVID-19 (poster). Conference. National Consortium of Breast Centers. Las Vegas, NV, US.
- 2021. Prediction of response to neoadjuvant systemic therapy in triple negative breast cancer using baseline tumor MRI characteristics and imaging patterns of response (scientific poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2021. Deep learning for early prediction of neoadjuvant chemotherapy response in triple negative breast cancers (scientific poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2021. Integrated model for early prediction of neoadjuvant systemic therapy response in triple negative breast cancer (spot-light poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2021. Radiomics model based on magnetic resonance image compilation (MagIC) as early predictor of pathologic complete response to neoadjuvant systemic therapy in triple-negative breast cancer (spot-light poster). Conference. San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2021. A composite model for pathologic complete response (pCR) prediction in triple negative breast cancer (TNBC) (scientific poster). Conference. 107th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2021. Prediction of pathologic complete response in triple negative breast cancer using baseline tumor MRI characteristics and patterns of response during neoadjuvant chemotherapy (scientific poster). Conference. 107th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2021. Immunogenic response and abnormal axillary node morphology in triple negative breast cancer patients (scientific poster). Conference. 107th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2021. Early prediction of chemoresistance versus excellent response in triple negative breast cancer patients (TNBC) with DCE-MRI (scientific poster). Conference. 107th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2021. Prediction of pathological complete response to neoadjuvant systemic therapy of triple negative breast cancers via deep learning (scientific poster). Conference. 107th Annual Meeting and Scientific Assembly of the Radiological Society of North America. Chicago, IL, US.
- 2021. Preoperative bracketing of multifocal breast carcinoma: A multimodality approach (electronic exhibit). Conference. Society of Breast Imaging/American College of Radiology Breast Imaging Symposium (virtual), US.
- 2020. Challenging cases in breast localization: A multimodality approach (electronic exhibit). Conference. 106th Scientific Assembly and Annual Meeting of the Radiological Society of North America (virtual). Chicago, IL, US.
- 2020. Nuts and bolts of MRI-guided biopsy (electronic exhibit). Conference. 106th Scientific Assembly and Annual Meeting of the Radiological Society of North America (virtual). Chicago, IL, US.
- 2019. The feasibility of breast conservation therapy in multifocal/multicentric breast cancer using multiple radioactive seeds: A paradigm shift. Conference. 105th Scientific Assembly and Annual Meeting of the Radiological Society of North America. Chicago, IL, US.
- 2019. Beyond invasive ductal carcinoma: A review of unusual breast malignancies (oral presentation and electronic exhibit). Conference. American Roentgen Ray Society 119th Annual Meeting. Honolulu, HI, US.
- 2019. Benign mimickers of breast malignancy (oral presentation and electronic exhibit). Conference. American Roentgen Ray Society 119th Annual Meeting. Honolulu, HI, US.
Grant & Contract Support
| Date: | 2022 - 2024 |
| Title: | Targeted axillary dissection and deep learning radiomics to predict axillary nodal burden pre-operatively in HR+/Her2-, node-positive breast cancer undergoing upfront surgery |
| Funding Source: | The University of Texas MD Anderson Cancer Center Institutional Research Grant |
| Role: | Co-I |
| ID: | 2023-00061839-Y1 |
Patient Reviews
CV information above last modified April 18, 2025