Mary Guirguis, M.D.
Department of Breast Imaging, Division of Diagnostic Imaging
About Dr. Mary Guirguis
Dr. Guirguis is a faculty member in the department of breast imaging. She is passionate about clinical service and trainee education. Her clinical and research interests include breast conservation therapy, triple negative breast cancer, preoperative localization, digital breast tomosynthesis, and breast MRI.
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Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Breast Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Breast Conservation Therapy
Preoperative Localization
Triple Negative Breast Cancer
Breast MRI
Clinical Interests
Resident and fellow education
Digital Breast Tomosynthesis
Preoperative localization
Education & Training
Degree-Granting Education
| 2013 | The University of Texas Medical School at Houston (McGovern Medical School), Houston, Texas, US, MD |
| 2009 | University of Houston, Houston, Texas, US, German, BA |
| 2009 | University of Houston, Houston, Texas, US, Biology, BS |
Postgraduate Training
| 2018-2019 | Clinical Fellowship, Breast and Body Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2017-2017 | Healthcare Management Certificate, University of Houston Clear Lake, Houston, Texas |
| 2014-2018 | Clinical Residency, Diagnostic Radiology, The University of Texas Medical School at Houston (McGovern Medical School), Houston, Texas |
| 2013-2014 | Clinical Internship, Internal Medicine, Presbyterian Hospital Dallas, Dallas, Texas |
Board Certifications
| 2019 | American Board of Radiology |
Experience & Service
Academic Appointments
Assistant Professor, Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2024
Assistant Professor, Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2019
Selected Publications
Peer-Reviewed Articles
- Weaver OO, Contreras A, Cohen EO, Guirguis MS, Kapoor MM, Scoggins ME, Hwang RF, Candelaria RP, Yang WT, Dennison JB, Sun J, Whitman GJ. Assessment of pectoralis muscle invasion using combined DBT and contrast-enhanced mammography: Retrospective multi-reader study. Curr Probl Diagn Radiol, 2025. e-Pub 2025. PMID: 40288929.
- Xu Z, Zhou Z, Son JB, Feng H, Adrada BE, Moseley T, Candelaria RP, Guirguis MS, Patel MM, Whitman GJ, Leung J, Le-Petross HT, Mohamed,RM, Panthi B, Lane DL, Chen H, Wei P, Tripathy D, Litton JK, Valero V, Huo L, Hunt KK, Korkut A, Thompson A, Yang W, Yam C, Rauch GM, Ma J. Deep learning models based on pretreatment MRI and clinicopathological data to predict response to neoadjuvant systemic therapy in triple-negative breast cancer. Cancers (Basel), 2025. e-Pub 2025. PMID: 40149299.
- Xu Z, Zhou Z, Son JB, Feng H, Adrada BE, Moseley T, Candelaria RP, Guirguis MS, Patel MM, Whitman GJ, Leun, J, Le-Petross H, Mohamed R, Panthi B, Lane DL, Chen H, Wei P, Tripathy D, Litton J, Valero V, Huo L, Hunt K K, Korkut A, Thompson A, Yang W, Yam C, Rauch G M, Ma J. Deep Learning Models Based on Pretreatment MRI and Clinicopathological Data to Predict Responses to Neoadjuvant Systemic Therapy in Triple-Negative Breast Cancer. Cancers 17(6), 2025. e-Pub 2025. PMID: 40149299.
- Mohamed RM, Panthi B, Adrada BE, Boge M, Candelaria RP, Chen H, Guirguis MS, Hunt KK, Huo L, Hwang K, Korkut A, Litton JK, Moseley T, Pashapoor S, Patel MM, Reed BJ, Scoggins ME, Son JB, Thompson A, Tripathy D, Valero V, Wei P, White JB, Whitman GJ, Xu Z, Yang W, Yam C, Ma J, Rauch GM. Multiparametric MRI–based radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer. Sci Rep 14(1), 2024. e-Pub 2024. PMID: 38992094.
- Musall BC, Rauch DE, Mohamed RMM, Panthi B, Boge M, Candelaria RP, Chen H, Guirguis MS, Hunt KK, Huo L, Hwang KP, Korkut A, Litton JK, Moseley TW, Pashapoor S, Patel MM, Reed BJ, Scoggins ME, Son JB, Tripathy D, Valero V, Wei P, White JB, Whitman GJ, Xu Z, Yang WT, Yam C, Adrada BE, Ma J. Diffusion tensor imaging for characterizing changes in triple-negative breast cancer during neoadjuvant systemic therapy. Journal of Magnetic Resonance Imaging 60(4):1367-1376, 2024. e-Pub 2024. PMID: 38294179.
- Nia E, Patel M, Kapoor M, Guirguis MS, Perez F, Bassett R, Candelaria R. Comparing the performance of full-field digital mammography and digital breast tomosynthesis in the post-treatment surveillance of patients with a history of breast cancer: A retrospective study. Radiography 29(6):957-979, 2023. e-Pub 2023. PMID: 37572571.
- Zhou Z, Adrada BE, Candelaria RP, Elshafeey N, Boge M, Mohamed RM, Pashapoo, S, Sun J, Xu Z, Panthi B, Son JB, Guirguis MS, Patel MM, Whitman GJ, Moseley T, Scoggins ME, White JB, Litton J, Valero V, Hunt KK, Tripathy D, Yang W, Wei P, Yam C, Pagel MD, Rauch GM, Ma J. Predicting pathological complete response to neoadjuvant systemic therapy for triple-negative breast cancers using deep learning on multiparametric MRIs. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2023:1-4, 2023. e-Pub 2023. PMID: 38083160.
- Panthi B, Adrada BE, Candelaria RP, Guirguis MS, Yam C, Boge M, Chen H, Hunt KK, Huo L, Hwang KP, Korkut A, Lane DL, Le-Petross HC, Leung JWT, Litton JK, Mohamed RM, Musall BC, Pashapoor S, Patel MM, Perez F, Son JB, Thompson A, Valero V, Wei P, White J, Xu Z, Pinsky L, Tripathy D, Yang W, Ma J, Rauch GM. Assessment of response to neoadjuvant systemic treatment in triple-negative breast cancer using functional tumor volumes from longitudinal dynamic contrast-enhanced MRI. Cancers (Basel) 15(4):1025, 2023. e-Pub 2023. PMID: 36831368.
- Zhou Z, Adrada BE, Candelaria RP, Elshafeey NA, Boge M, Mohamed RM, Pashapoor S, Sun J, Xu Z, Panthi B, Son JB, Guirguis MS, Patel MM, Whitman GJ, Moseley TW, Scoggins ME, White JB, Litton JK, Valero V, Hunt KK, Tripathy D, Yang W, Wei P, Yam C, Pagel MD, Rauch GM, Ma J. Prediction of pathologic complete response to neoadjuvant systemic therapy in triple negative breast cancer using deep learning on multiparametric MRI. Sci Rep 13(1):1171, 2023. e-Pub 2023. PMID: 36670144.
- Guirguis MS, Checka C, Adrada BE, Whitman GJ, Dryden MJ, Sun J, Ding QQ, Le-Petross H, Rauch GM, Clemens M, Moseley TW. Bracketing with multiple radioactive seeds to achieve negative margins in breast conservation surgery: Multiple seeds in breast surgery. Clin Breast Cancer 22(2):e158-e166, 2022. e-Pub 2022. PMID: 34187752.
- Candelaria RP, Spak DA, Rauch GM, Huo L, Bassett RL, Santiago L, Scoggins ME, Guirguis MS, Patel MM, Whitman GJ, Moulder SL, Thompson AM, Ravenberg EE, White JB, Abuhadra NK, Valero V, Litton J, Adrada BE, Yang WT. BI-RADS ultrasound lexicon descriptors and stromal tumor-infiltrating lymphocytes in triple-negative breast cancer. Acad Radiol 29 Suppl 1(Suppl 1):S35-S41, 2022. e-Pub 2022. PMID: 34272161.
- Lindsey JW, Khan U, Ansari W, Powell T, Wang YH, Guirguis MS. The antibody response to Epstein-Barr virions is altered in multiple sclerosis. J Neuroimmunol 15(254):146-53, 2013. e-Pub 2013. PMID: 23026221.
Invited Articles
- Pria HD, Scoggins ME, Moseley T, Vishwanath V, Jean S, Vuong S, Diaz V, Elhatw A, Patel MM, Guirguis MS. Current Status of Imaging for Breast Cancer Staging. Current Breast Cancer Reports 16(2):126-133, 2024. e-Pub 2024.
- Patel MM, Le-Petross HT, Kapoor MM, Farag JA, Whitman G, Guirguis MS. Current Imaging Approaches in Inflammatory Breast Cancer. Curr Breast Cancer Rep 16:142-149, 2024. e-Pub 2024.
- Ferreira Dalla Pria HR, Scoggins Marion E, Moseley Tanya W, Vishwanath Varnita, Jean Shanen, Vuong Stephanie, Diaz Valentina, Elhatw Ahmed, Patel Miral M, Guirguis Mary S. Current status of imaging for breast cancer staging. Curr Breast Cancer Rep 16(1):126-133, 2024. e-Pub 2024.
- Patel MM, Adrada BE, Nia ES, Kapoor MM, Khazai L, Guirguis MS, Perez F, Moseley TW, Arribas EM. Multimodality imaging of breast cancer recurrence post breast conservation therapy. Curr Radiol Rep 12:9-18, 2024. e-Pub 2024.
- Chung HL, Joiner J, Pria HR, Jean S, Vishwanath V, De Jesus C, Elhatw A, Guirguis MS, Patel MM, Moseley TW. Breast imaging considerations in symptomatic young, pregnant, and lactating women. Curr Breast Cancer Rep 15(2):119-126, 2023. e-Pub 2023.
- DeJesus C, Moseley TW, Diaz V, Vishwanath V, Jean S, Elhatw A, Ferreira Dalla Pria HR, Chung HL, Guirguis MS, Patel MM. Supplemental screening for breast cancer. Curr Breast Cancer Rep 15(2):97-102, 2023. e-Pub 2023.
- De Jesus C, Moseley TW, Diaz V, Vishwanath V, Jean S, Elhatw A, Ferreira Dalla Pria HR, Chung HL, Guirguis MS, Patel MM. The benefits of screening mammography. Curr Breast Cancer Rep 15(2):103-107, 2023. e-Pub 2023.
- Elhatw A, Chung HL, Kamal RM, De Jesus C, Jean S, Vishwanath V, Ferreira Dalla Pria HR, Patel MM, Guirguis MS, Moseley TW. Advanced breast imaging modalities — DBT, CEM, MBI, PEM, MRI, AI. Curr Breast Cancer Rep 15(2):108-113, 2023. e-Pub 2023.
Other Articles
- Patel MM, Adrada BE, Guirguis MS, Whitman G, Moseley TW, Rauch GM Current concepts of molecular breast imaging. J Breast Imaging 7(1):104-118, 2025. PMID: 39692400.
- Fazeli Soudabeh, Stepenosky J, Guirguis MS, Adrada BE, Rakow-Penner R, Ojeda-Fournier H Understanding BI-RADS Category 3. Radiographics 45(1), 2025. PMID: 39636752.
- Guirguis MS, Arribas E, Kapoor MM, Patel MM, Perez F, Nia ES, Ding Q, Moseley TW, Adrada BE Multimodality imaging of benign and malignant pathologies of the nipple areolar complex. Radiographics 44(4), 2024. PMID: 38483829.
- Patel MM, Adrada BE, Nia ES, Kapoor MM, Khazai L, Guirguis MS, Perez F, Moseley T, Arribas E Multimodality Imaging of Breast Cancer Recurrence Post Breast Conservation Therapy. Current Radiology Reports 12(2):9-18, 2024.
- Adrada BE, Moseley TW, Kapoor MM, Scoggins ME, Patel MM, Perez F, Nia ES, Khazai L, Arribas E, Rauch GM, Guirguis MS Triple-Negative breast cancer: A review of histopathology, genomics, and treatment. Radiographics 43(10):e230034, 2023. PMID: 37792593.
- Guirguis MS, Yang WT Overview of incidental breast lesions. Br J Radiol 96(1142):20211326, 2023. PMID: 35451861.
- Guirguis MS, Adrada BE, Scoggins ME, Moseley TW, Dryden MJ, Le-Petross HC, Rauch GM, Whitman GJ The challenging image-guided preoperative breast localization: A modality-based approach. AJR Am J Roentgenol 218(3):1-12, 2022. PMID: 34612680.
- Adrada BE, Guirguis MS, Hoang T, Spak DA, Rauch GM, Moseley TW MRI-guided breast biopsy case-based review: Essential techniques and approaches to challenging cases. Radiographics 42(2):210126, 2022. PMID: 35119965.
- Noreña-Rengifo BD, Sanín-Ramírez MP, Adrada BE, Luengas AB, Martínez de Vega V, Guirguis MS, Saldarriaga-Uribe C MRI for evaluation of complications of breast augmentation. Radiographics 42(4):210096, 2022. PMID: 35559662.
- Teichgraeber DC, Guirguis MS, Whitman GJ Breast cancer staging: Updates in the AJCC Cancer Staging Manual 8th Edition and Current Challenges for Radiologists, From the AJR Special Series on Cancer Staging. AJR Am J Roentgenol 217(2):278-290, 2021. PMID: 33594908.
- Guirguis MS, Adrada B, Santiago L, Candelaria R, Arribas E Mimickers of breast malignancy: Imaging findings, pathologic concordance and clinical management. Insights Imaging 12(1):53, 2021. PMID: 33877461.
- Guirguis MS, Adrada BE, Surasi DS, Dryden MJ 68Ga-DOTATATE uptake in primary breast cancer. Clin Nucl Med 46(3):248-249, 2021. PMID: 33234932.
- Teichgraeber DC, Perez F, Guirguis MS, Kapoor MM, Whitman GJ Ultrasound evaluation of the axilla in the breast imaging setting. Ultrasound Q 37(1):43-51, 2021. PMID: 33464028.
- Riascos R, Bonfante E, Cotes C, Guirguis MS, Hakimelahi R, West C Imaging of atlanto-occipital and atlantoaxial traumatic injuries: What the radiologist needs to know. Radiographics 35(7):2121-34, 2015. PMID: 26562241.
- Guirguis MS, Shroff GS Cement pulmonary embolism. Am J Med Sci 349(5):e5, 2015. PMID: 24534786.
- Shroff GS, Guirguis MS, Ocazionez D, Oldham SA, Restrepo CS, Chiles C Beyond metastatic disease: A pictorial review of multinodular lung disease with computed tomographic pathologic correlation. Can Assoc Radiol J 66(1):16-23, 2015. PMID: 25623007.
- Shroff GS, Guirguis MS, Ferguson EC, Oldham SA, Kantharia BK CT imaging of complications of catheter ablation for atrial fibrillation. Clin Radiol 69(1):96-102, 2014. PMID: 24268510.
Abstracts
- Mohamed RM, Panthi B, Adrada B, Candelaria R, Guirguis MS, Yang W, Boge M, Patel M, Elshafeey N, Pashapoor S, Zhou Z, Son JB, Hwang KP, Le-Petross HT, Leung J, Scoggins ME, Whitman GJ, Xu Z, Lane DL, Moseley T, Perez F, White J, Chen H, Sun J, Wei P, Litton JK, Valero V, Yam C, Pagel M, Ma J, Rauch GM. A pre-operative dynamic contrast enhanced MRI-based radiomics models as predictors of treatment response after neoadjuvant systemic therapy in triple negative breast cancer patients. Cancer Res 83(5):1307535, 2023. e-Pub 2023.
- Mohamed RM, Panthi B, Adrada BE, Candelaria RP, Guirguis MS, Yang W, Boge M, Patel MM, Elshafeey NA, Pashapoor S, Zhou Z, Son JB, Hwang KP, Le-Petross HC, Leung J, Scoggins ME, Whitman GJ, Xu Z, Lane DL, Moseley T, Perez F, White JB, Ravenberg EE, Clayborn AR, Pagel MD, Chen H, Sun J, Wei P, Thompson A, Moulder S, Korkut A, Huo L, Hunt K, Litton J, Valero V, Tripathy D, Yam C, Ma J, Rauch GM. Multi-parametric MRI-based radiomics models from tumor and peritumoral regions as potential predictors of treatment response to neoadjuvant systemic therapy in triple negative breast cancer patients. Cancer Res 83(5):P6-01-06, 2023. e-Pub 2023.
- Panthi B, Mohamed RM, Adrada BE, Candelaria R, Guirguis MS, Yang W, Boge M, Patel M, Elsafeey N, Pashapoor S, Zhou Z, Son JB, Hwang KP, Le-Petross C, Leung J, Scoggins ME, Whitman GJ, Xu Z, Lane Deanna L, Moseley T, Perez F, White J, Ravenberg E, Clayborn A, Pagel M, Chen H, Sun J, Wei P, Thompson AM, Moulder S, Korkut A, Huo L, Hunt KK, Valero V, Tripathy D, Yam C, Ma J, Rauch G. Longitudinal DCE-MRI radiomic models for early prediction of response to neoadjuvant systemic therapy (NAST) in triple negative breast cancer (TNBC) patients. Cancer Res 83(5), 2023. e-Pub 2023.
- Guirguis MS, Adrada B, Patel M, Perez F, Candelaria R, Yang W, Sun J, Mohamed RM, Boge M, Le-Petross HTC, Leung J, Whitman GJ, Lane DL, Scoggins ME, Moseley T, Musal B, White J, Pashapoor S, Wei P, Son JB, Hwang K-P, Panthi B, Pagel M, Huo L, Hunt KK, Ravenberg E, Thompson AM, Litton JK, Valero V, Tripathy D, Moulder S, Yam C, Ma J, Rauch G. DCE-MRI for early prediction of excellent response versus chemoresistance in triple negative breast cancer. Cancer Res 83(5):P1-05-15, 2023. e-Pub 2023.
- Zhou Z, Elshafeey NA, Rauch DE, Adrada BE, Candelaria RP, Guirguis MS, Yang W, Boge M, Mohamed RM, Whitman GJ, Lane DL, Le-Petross HC, Leung JWT, Santiago L, Scoggins ME, Spak DA, Patel MM, Perez F, Tripathy D, Valero V, Yam C, Moulder S, White JB, Son JB, Pagel MD, Rauch GM, Ma J. Deep learning for early prediction of neoadjuvant chemotherapy response in triple negative breast cancers. Cancer Res 82(4):P1-08-03, 2022. e-Pub 2022.
- Rauch GM, Candelaria RP, Guirguis MS, Boge M, Mohamed RMM, Elshafeey N, Sun J, Whitman GJ, Leung J, Le-Petross HC, Santiago L, Lane D, Scoggins M, Spak D, Patel MM, Perez F, White JB, Ravenberg E, Peng W, Tripathy D, Valero V, Litton J, Huo L, Yam C, Thompson A, Ma J, Moulder SL, Yang W, Adrada BE. Integrated model for early prediction of neoadjuvant systemic therapy response in triple negative breast cancer. Cancer Res 82(4):PD11-07, 2022. e-Pub 2022.
- Guirguis MS, Adrada BE, Candelaria RP, Sun J, Whitman GJ, Yang WT, Boge M, Mohamed RM, Elshafeey NA, Lane DL, Le-Petross H, Leung JWT, Santiago L, Scoggins ME, Spak DA, Patel M, Perez F, Wei P, Tripathy D, White J, Ravenberg E, Huo L, Litton J, Arun B, Valero V, Thompson A, Moulder S, Yam C, Rauch GM. Prediction of response to neoadjuvant systemic therapy in triple negative breast cancer using baseline tumor MRI characteristics and imaging patterns of response. Cancer Res 82(4):P3-03-06, 2022. e-Pub 2022.
- Elshafeey N, Hwang KP, Adrada BE, Candelaria RP, Boge M, Mahmoud RM, Chen H, Sun J, Yang W, Kotrotsou A, Musall BC, Son JB, Whitman GJ, Leung J, Le-Petross H, Santiago L, Lane DL, Scoggins ME, Spak DA, Guirguis MS, Patel MM, Perez F, Abdelhafez AH, White JB, Hu L, Ravenberg E, Peng W, Thompson A, Damodaran S, Tripathy D, Moulder SL, Yam C, Pagel MD, Ma J, Rauch GM. Radiomics model based on magnetic resonance image compilation (MagIC) as early predictor of pathologic complete response to neoadjuvant systemic therapy in triple-negative breast cancer. Cancer Res 82(4):PD11-06, 2022. e-Pub 2022.
- Guirguis MS, Beckmann N. Traumatic scapula fractures: A review of classifications and management. Emerg Radiol(29):219-225, 2018. e-Pub 2018.
- Guirguis MS, Ko A, Chinapuvvula NR. Imaging of acute pelvic pain in the premenopausal female: How to ensure timely surgical management. Emerg Radiol(22):457-510, 2016. e-Pub 2016.
Letters to the Editor
- Guirguis MS, Adrada BE, Scoggins ME, Moseley TW, Whitman GJ. Reply to "Additional references relevant to preoperative breast lesion localization techniques". AJR Am J Roentgenol 218: 1, 2022.
- Shroff GS, Guirguis MS, Ferguson EC, Oldham SA, Kantharia BK. Re: CT imaging of complications of catheter ablation for atrial fibrillation. A reply. Clin Radiol 69: 369, 2014.
Patient Reviews
CV information above last modified June 06, 2025