Michael Andreeff, M.D., Ph.D.
Department of Leukemia, Division of Cancer Medicine
About Dr. Andreeff
Dr. Andreeff received his M.D. and Ph.D. degrees at the University of Heidelberg, Germany, and additional training and faculty appointments at the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York, NY, in the Departments of Pathology and Leukemia.
Dr. Andreeff has been a pioneer in flow cytometry since 1971, when he established the first flow cytometry laboratory at the University of Heidelberg,and organized the first European conference on flow cytometry. In 1977 he joined Memorial Sloan-Kettering Cancer Center in New York, NY, became head of the Leukemia Cell Biology and Hematopathology Flow Cytometry Laboratory, organized the first Clinical Cytometry Conference in 1986 and the first Molecular Cytogenetics Conference in 1990.
He is Professor of Medicine and holds the Paul and Mary Haas Chair in Genetics at The University of Texas MD Anderson Cancer Center. He has received uninterrupted NCI funding for over 30 years, serves as Principal Investigator of the P01 grant entitled “The Therapy of AML”, participates as Principal Investigator in the MD Anderson Cancer Center Leukemia, Lymphoma, Ovarian and Breast Cancer SPORE grants, the CML P01 and additional R21 and R01 grants. He has published over 639 peer-reviewed papers, 5 books and 75 book chapters
Dr Andreeff’s group has worked extensively on drug resistance in hematopoietic malignancies and breast cancer and developed or co-developed several new therapeutic agents including the novel triterpenoids CDDO and CDDO-Me and Bcl-2-, XIAP-, surviving-, MEK- and HDM2- inhibitors. Over the last decade, his group has made major contributions to the understanding of micro-environment-mediated drug resistance and developed strategies to exploit the underlying mechanisms for the treatment of hematopoietic and epithelial malignancies. His group reported the role of bone marrow-derived multipotent mesenchymal stromal cells (MSC) in tumor stroma formation and developed therapeutic strategies based on this discovery.
Present Title & Affiliation
Primary Appointment
Professor of Medicine, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor of Medicine, Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
1976 | University of Heidelberg Medical School, Heidelberg, DEU, Ph.D, Cell Biology |
1968 | University of Heidelberg Medical School, Heidelberg, DEU, M.D, Medicine |
1964 | University of Muenster Medical School, Muenster, DEU, OTH, Medicine & Psychology |
Experience & Service
Academic Appointments
Professor of Medicine (tenured); Chief, Leukemia Section; Inpatient Service Chief (Leukemia); Chief, Section of Experimental Hematology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1990 - 1995
Administrative Appointments/Responsibilities
Chief, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 1995 - Present
Director, Flow Cytometry and Cellular Imaging Facility (FCCIF)(CCSG Laboratory-NCI Funded), The University of Texas MD Anderson Cancer Center, Houston, TX, 1990 - Present
Director, Bone Marrow Aspiration Clinic, Department of Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, 1990 - Present
Endowed Positions
Paul and Mary Haas Chair in Genetics, Division of Professor of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - Present
Consultantships
Consultant, Glycomimetics, Rockville, MD, 2020 - 2022
Honors & Awards
2019 | Fellow, Association of American Physicians, Association of American Physicians |
2018 | Celgene Award for Clinical Research in Hematology, Celgene |
2018 | Excellence in Entrepreneurship, UT MD Anderson Cancer Center - Division of Cancer Medicine |
2016 | Waun Ki Hong Award for Excellence in Team Science, UT MD Anderson Cancer Center |
2013 | Mentor Award, MD Anderson Alumni & Faculty Association Graduate Student Award in Translational/Population/Patient Research |
2013 | Fellow, American Association for the Advancement of Science, American Association for the Advancement of Science |
2012 | John Mendelsohn Lifetime Scientific Achievement Award, University of Texas MD Anderson Cancer Center |
2008 | Potu N. Rao Award for Excellence in Basic Science, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center |
2007 | Excellence in Research Mentorship Award, University of Texas MD Anderson Cancer Center |
2005 | Excellence in Research Mentorship Award, University of Texas MD Anderson Cancer Center |
2005 | Exceptional Leadership & Support as a Mentor Award, University of Texas MD Anderson Cancer Center |
1996 | Stringer Professor for Cancer Treatment and Research, The University of Texas M. D. Anderson Cancer Center |
1995 | Honorary Professor, 10th International Conference, Cd. Victoria, Mexico, "Medicine for the Next Century" |
1994 | Visiting Professorship Award, German Society of Hematology |
1993 | AMGEN Fellowship Award, AMGEN |
1991 | Fellowship award, International Union Against Cancer (UICC) |
1991 | Fellowship award , German Research Council |
1991 | Fellowship award , Mildred-Scheel-Foundation |
1991 | Fellowship award , Max-Kade-Foundation |
1991 | Fellowship award , Italian Research Council |
1991 | Fellowship award , Government of Egypt |
1991 | Fellowship award , World Health Organization |
1991 | Fellowship award , National Childhood Cancer Foundation |
1985 | Kind-Phillip-Award for Leukemia Research, German Society for Pediatric Oncology |
1976 | Cancer Research Award, University of Mainz, Germany |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, Ikeo K, Ruvolo V, Zhang W, Mak P, Kaczkowski B, Harada H, Katayama K, Sugimoto Y, Myslinski J, Hato T, Miida T, Konopleva M, Andreeff M. Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML. Translational Oncology 18, 2022. e-Pub 2022.
- Borthakur G, Zeng Z, Cortes JE, Chen HC, Huang X, Konopleva M, Ravandi F, Kadia T, Patel KP, Daver N, Kelly MA, McQueen T, Wang RY, Kantarjian H, Andreeff M. Phase 1 Study of combinatorial sorafenib, G-CSF, and plerixafor treatment in relapsed/refractory, FLT3-ITD-mutated acute myelogenous leukemia patients. Am J Hematol 95(11):1296-1303, 2020. e-Pub 2020. PMID: 32697348.
- Daver N, Price A, Benton CB, Patel K, Zhang W, Konopleva M, Pemmaraju N, Takahashi K, Andreeff M, Borthakur G. First Report of Sorafenib in Patients with Acute Myeloid Leukemia Harboring Non- canonical FLT3-mutations. Front Oncol 10:1538, 2020. e-Pub 2020. PMID: 32984009.
- Young KH, Deng M, Zhang M, Pham VL, Tzankov A, Visco C, Bhagat G, Dybkaer K, Chiu A, Tam W, Zu Y, His ED, Choi WWL, Huh J, Ponzoni M, Ferreri AJM, Møller MB, Parsons BM, van Krieken JH, Piris AM, Winter JM, Hagemeister F, Alinari L, Li Y, Andreeff M, Xu-Monette ZY, Xu B.. XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor 13(1):148, 2020. PMID: 33148342.
- Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Nishida Y, Kojima K, Garnett MJ, McDermott U, Benes CH, Charter N, Deacon S, Elemento O, Allen JE, Oster W, Stogniew M, Ishizawa J, Andreeff M. Imipridone ONC212 targets the orphan G protein-coupled receptor GPR132 in acute myeloid leukemia. Leukemia 33(12):2805-2816, 2019. e-Pub 2019. PMID: 31127149.
- Beeharry N, Landrette S, Gayle S, Hernandez M, Grotzke JE, Young PR, Beckett P, Zhang X, Carter BZ, Andreeff M, Halene S, Xu T, Rothberg J, Lichenstein H. LAM-003, a New Drug for Treatment of Tyrosine Kinase Inhibitor-Resistant FLT3-ITD Positive AML. Blood Adv 3(22):3661-3673, 2019. PMID: 31751472.
- Yalniz F, Abou Dalle I, Kantarjian H, Borthakur G, Kadia T, Patel K, Loghavi S, Garcia-Manero G, Sasaki K, Daver N, DiNardo C, Pemmaraju N, Short NJ, Yilmaz M, Bose P, Naqvi K, Pierce S, Nogueras González GM, Konopleva M, Andreeff M, Cortes J, Ravandi F. Prognostic Significance of Baseline FLT3- ITD Mutant Allele Level in Acute Myeloid Leukemia Treated with Intensive Chemotherapy With/Without Sorafenib. Am J Hematol 94(9):984-991, 2019. e-Pub 2019. PMID: 31237017.
- Benton CB, Boddu PC, DiNardo CD, Bose P, Wang F, Assi R, Pemmaraju N, Kc D, Pierce S, Patel K, Konopleva M, Ravandi F, Garcia-Manero G, Kadia TM, Cortes J, Kantarjian HM, Andreeff M, Verstovsek S. Janus kinase 2 variants associated with the transformation of myeloproliferative neoplasms into acute myeloid leukemia. Cancer 125(11):1855-1866, 2019. e-Pub 2019. PMID: 30811597.
- Ruvolo PP, Hu CW, Qiu Y, Ruvolo VR, Go RL, Hubner SE, Coombes KR, Andreeff M, Qutub AA, Kornblau SM. LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML. EBioMedicine 44(2019):126–137, 2019. e-Pub 2019. PMID: 31105032.
- Williams P, Basu S, Garcia-Manero G, Hourigan CS, Oetjen KA, Cortes JE, Ravandi F, Jabbour EJ, Al-Hamal Z, Konopleva M, Ning J, Xiao L, Hidalgo Lopez J, Kornblau SM, Andreeff M, Flores W, Bueso-Ramos C, Blando J, Galera P, Calvo KR, Al-Atrash G, Allison JP, Kantarjian HM, Sharma P, Daver NG. The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia. Cancer 125(9):1470-1481, 2019. e-Pub 2018. PMID: 30500073.
- Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M. Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality. Cancer Cell 35(5):721-737, 2019. e-Pub 2019. PMID: 31056398.
- Piya S, Mu H, Bhattacharya S, Lorenzi PL, Davis RE, McQueen T, Ruvolo V, Baran N, Wang Z, Qian Y, Crews CM, Konopleva M, Ishizawa J, You MJ, Kantarjian H, Andreeff M, Borthakur G. BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment. J Clin Invest 130(5):1878-1894, 2019. e-Pub 2019. PMID: 30829648.
- Han L, Zhang Q, Dail M, Shi C, Cavazos A, Ruvolo VR, Zhao Y, Kim E, Rahmani M, Mak DH, Jin SS, Chen J, Phillips DC, Bottecelli Koller P, Jacamo R, Burks JK, DiNardo C, Daver N, Jabbour E, Wang J, Kantarjian HM, Andreeff M, Grant S, Leverson JD, Sampath D, Konopleva M. Concomitant Targeting of BCL2 with Venetoclax and MAPK Signaling with Cobimetinib in Acute Myeloid Leukemia Models. Haematologica. e-Pub 2019. PMID: 31123034.
- Burger JA, Sivina M, Jain N, Kim E, Kadia T, Estrov Z, Nogueras-Gonzalez GM, Huang X, Jorgensen J, Li J, Cheng M, Clow F, Ohanian M, Andreeff M, Mathew T, Thompson P, Kantarjian H, O'Brien S, Wierda WG, Ferrajoli A, Keating MJ. Randomized trial of ibrutinib versus ibrutinib plus rituximab in patients with chronic lymphocytic leukemia. Blood 133(10):1011-1019, 2019. e-Pub 2018. PMID: 30530801.
- Carter BZ, Mak PY, Wang X, Tao W, Ruvolo V, Mak D, Mu H, Burks JK, Andreeff M. An ARC-regulated IL1β/Cox-2/PGE2/β-catenin/ARC circuit controls leukemia-microenvironment interactions and confers drug resistance in AML. Cancer Res 79(6):1165-1177, 2019. e-Pub 2019. PMID: 30674535.
- Daver N, Garcia-Manero G, Basu S, Boddu PC, Alfayez M, Cortes JE, Konopleva M, Ravandi-Kashani F, Jabbour E, Kadia T, Nogueras-Gonzalez GM, Ning J, Pemmaraju N, DiNardo CD, Andreeff M, Pierce SA, Gordon T, Kornblau SM, Flores W, Alhamal Z, Bueso-Ramos C, Jorgensen JL, Patel KP, Blando J, Allison JP, Sharma P, Kantarjian H. Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Non-randomized, Open-label, Phase 2 Study. Cancer Discov 9(3):370-383, 2019. e-Pub 2018. PMID: 30409776.
- Ohanian M, Rozovski U, Kanagal-Shamanna R, Abruzzo LV, Loghavi S, Kadia T, Futreal A, Bhalla K, Zuo Z, Huh YO, Post SM, Ruvolo P, Garcia-Manero G, Andreeff M, Kornblau S, Borthakur G, Hu P, Medeiros LJ, Takahashi K, Hornbaker MJ, Zhang J, Nogueras-González GM, Huang X, Verstovsek S, Estrov Z, Pierce S, Ravandi F, Kantarjian HM, Bueso-Ramos CE, Cortes JE. MYC protein expression is an important prognostic factor in acute myeloid leukemia. Leuk Lymphoma 60(1):37-48, 2019. e-Pub 2018. PMID: 29741984.
- Short NJ, Jabbour E, Naqvi K, Patel A, Ning J, Sasaki K, Nogueras-Gonzalez GM, Bose P, Kornblau SM, Takahashi K, Andreeff M, Sanchez-Petitto G, Estrov Z, Dinardo CD, Montalban-Bravo G, Konopleva M, Alvarado Y, Bhalla KN, Fiskus W, Khouri M, Islam R, Kantarjian H, Garcia-Manero G. A phase II study of omacetaxine mepesuccinate for patients with higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia after failure of hypomethylating agents. Am J Hematol 94(1):74-79, 2019. e-Pub 2018. PMID: 30328139.
- Le PM, Andreeff M, Battula VL. Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis. Haematologica 103(12):1945-1955, 2018. e-Pub 2018. PMID: 30337364.
- Nguyen K, Yan Y, Yuan B, Dasgupta A, Sun J, Mu H, Do KA, Ueno NT, Andreeff M, Battula VL. ST8SIA1 regulates tumor growth and metastasis in TNBC by activating the FAK-AKT-mTOR signaling pathway. Mol Cancer Ther 12(12):2689-2701, 2018. e-Pub 2018. PMID: 30237308.
- Tabe Y, Saitoh K, Yang H, Sekihara K, Yamatani K, Ruvolo V, Taka H, Kaga N, Kikkawa M, Arai H, Miida T, Andreeff M, Spagnuolo PA, Konopleva M. Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine. Sci Rep 8(1):16837, 2018. e-Pub 2018. PMID: 30442990.
- Rassidakis GZ, Herold N, Myrberg IH, Tsesmetzis N, Rudd SG, Henter JI, Schaller T, Ng SB, Chng WJ, Yan B, Ng CH, Ravandi F, Andreeff M, Kantarjian HM, Medeiros LJ, Xagoraris I, Khoury JD. Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens. Blood Cancer J 8(11):98, 2018. e-Pub 2018. PMID: 30341277.
- Benton CB, Khan M, Sallman D, Nazha A, Nogueras González GM, Piao J, Ning J, Aung F, Al Ali N, Jabbour E, Kadia TM, Borthakur G, Ravandi F, Pierce S, Steensma D, DeZern A, Roboz G, Sekeres M, Andreeff M, Kantarjian H, Komrokji RS, Garcia-Manero G. Prognosis of patients with intermediate risk IPSS-R myelodysplastic syndrome indicates variable outcomes and need for models beyond IPSS-R. Am J Hematol 93(10):1245-1253, 2018. e-Pub 2018. PMID: 30051599.
- Zhang W, Ly C, Ishizawa J, Mu H, Ruvolo V, Shacham S, Daver N, Andreeff M. Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial. Haematologica 103(10):1642-1653, 2018. e-Pub 2018. PMID: 29773601.
- Ohanian M, Garcia-Manero G, Levis M, Jabbour E, Daver N, Borthakur G, Kadia T, Pierce S, Burger J, Richie MA, Patel K, Andreeff M, Estrov Z, Cortes J, Kantarjian H, Ravandi F. Sorafenib Combined with 5-azacytidine (AZA) in Older Patients with Untreated FLT3-ITD Mutated Acute Myeloid Leukemia (AML). Am J Hematol 93(93):1136-1141, 2018. e-Pub 2018. PMID: 30028037.
- Boddu P, Kantarjian H, Ravandi F, Garcia-Manero G, Borthakur G, Andreeff M, Jabbour EJ, Benton CB, DiNardo CD, Konopleva M, Daver N, Patel K, Takahashi K, Kanagal-Shamanna R, Cortes J, Kadia T. Outcomes with Lower Intensity Therapy in TP53-Mutated Acute Myeloid Leukemia. Leuk Lymphoma 59(9):2238-2241, 2018. e-Pub 2018. PMID: 29338567.
- Takahashi K, Wang F, Morita K, Yan Y, Hu P, Zhao P, Zhar AA, Wu CJ, Gumbs C, Little L, Tippen S, Thornton R, Coyle M, Mendoza M, Thompson E, Zhang J, DiNardo CD, Jain N, Ravandi F, Cortes JE, Garcia-Manero G, Kornblau S, Andreeff M, Jabbour E, Bueso-Ramos C, Takaori-Kondo A, Konopleva M, Patel K, Kantarjian H, Futreal PA. Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes. Nat Commun 9(1):2670, 2018. e-Pub 2018. PMID: 29991687.
- Ruvolo PP, Ruvolo VR, Burks JK, Qiu Y, Wang RY, Shpall EJ, Mirandola L, Hail N, Zeng Z, McQueen T, Daver N, Post SM, Chiriva-Internati M, Kornblau SM, Andreeff M. Role of MSC derived Galectin 3 in the AML microenvironment. Biochim Biophys Acta Mol Cell Res 1865(7):959-969, 2018. e-Pub 2018. PMID: 29655803.
- Morita K, Kantarjian HM, Wang F, Yan Y, Bueso-Ramos C, Sasaki K, Issa GC, Wang S, Jorgensen J, Song X, Zhang J, Tippen S, Thornton R, Coyle M, Little L, Gumbs C, Pemmaraju N, Daver N, DiNardo CD, Konopleva M, Andreeff M, Ravandi F, Cortes JE, Kadia T, Jabbour E, Garcia-Manero G, Patel KP, Futreal PA, Takahashi K. Clearance of somatic mutations at remission and the risk of relapse in acute myeloid leukemia. J Clin Oncol 36(18):1788-1797, 2018. e-Pub 2018. PMID: 29702001.
- Ishizawa J, Nakamaru K, Seki T, Tazaki K, Kojima K, Chachad D, Zhao R, Heese LE, Ma W, Ma MCJ, DiNardo CD, Pierce SA, Patel KP, Tse A, Davis RE, Rao A, Andreeff M. Predictive gene signatures determine tumor sensitivity to MDM2 inhibition. Cancer Res 78(10):2721-2731, 2018. e-Pub 2018. PMID: 29490944.
- Kornblau SM, Ruvolo PP, Wang RY, Battula VL, Shpall EJ, Ruvolo VR, McQueen T, Qui Y, Zeng Z, Pierce S, Jacamo R, Yoo SY, Le PM, Sun J, Hail N, Konopleva M, Andreeff M. Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival. Haematologica 103(5):810-821, 2018. e-Pub 2018. PMID: 29545342.
- Jiang X, Mak PY, Mu H, Tao W, Mak DH, Kornblau S, Zhang Q, Ruvolo P, Burks JK, Zhang W, McQueen T, Pan R, Zhou H, Konopleva M, Cortes J, Liu Q, Andreeff M, Carter BZ. Disruption of Wnt/β-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia. Clin Cancer Res 24(10):2417-2429, 2018. e-Pub 2018. PMID: 29463558.
- Kornblau SM, Ruvolo PP, Wang RY, Battula VL, Shpall EJ, Ruvolo VR, McQueen T, Qui Y, Zeng Z, Pierce S, Jacamo R, Yoo SY, Le PM, Sun J, Hail N, Konopleva M, Andreeff M. Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival. Haematologica 103(5):810-821, 2018. e-Pub 2018. PMID: 29545342.
- Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Oxidized Analogs of Di(1H-indol-3-yl)methyl-4-substituted Benzenes are NR4A1-dependent UPR Inducers with Potent and Safe Anti-Cancer Activity. Oncotarget 9(38):25057-25074, 2018. e-Pub 2018. PMID: 29861853.
- Ohanian M, Tari Ashizawa A, Garcia-Manero G, Pemmaraju N, Kadia T, Jabbour E, Ravandi F, Borthakur G, Andreeff M, Konopleva M, Lim M, Pierce S, O'Brien S, Alvarado Y, Verstovsek S, Wierda W, Kantarjian H, Cortes J. Liposomal Grb2 antisense oligodeoxynucleotide (BP1001) in patients with refractory or relapsed haematological malignancies: a single-centre, open-label, dose-escalation, phase 1/1b trial. Lancet Haematol 5(4):e136-e146, 2018. e-Pub 2018. PMID: 29550383.
- Ngankeu A, Ranganathan P, Havelange V, Nicolet D, Volinia S, Powell BL, Kolitz JE, Uy GL, Stone RM, Kornblau SM, Andreeff M, Croce CM, Bloomfield CD, Garzon R. Discovery and functional implications of a miR-29b-1/miR-29a cluster polymorphism in acute myeloid leukemia. Oncotarget 9(4):4354-4365, 2018. e-Pub 2017. PMID: 29435107.
- Chamoun K, Loghavi S, Pemmaraju N, Konopleva M, Kroll M, Nguyen-Cao M, Hornbaker M, DiNardo CD, Kadia T, Jorgensen J, Andreeff M, Hu S, Benton CB. Early detection of transformation to BPDCN in a patient with MDS. Exp Hematol Oncol 7:26, 2018. e-Pub 2018. PMID: 30323983.
- Boddu P, Borthakur G, Koneru M, Huang X, Naqvi K, Wierda W, Bose P, Jabbour E, Estrov Z, Burger J, Alvarado Y, Deshmukh A, Patel A, Cavazos A, Han L, Cortes JE, Kantarjian H, Andreeff M, Konopleva M. Initial Report of a Phase I Study of LY2510924, Idarubicin, and Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia. Front Oncol 8:369, 2018. e-Pub 2018. PMID: 30319961.
- Ruvolo PP, Ma H, Ruvolo VR, Zhang X, Mu H, Schober W, Hernandez I, Gallardo M, Khoury JD, Cortes J, Andreeff M, Post SM. Anexelekto/MER Tyrosine Kinase inhibitor ONO-7475 growth arrests and kills FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication Mutant Acute Myeloid Leukemia cells by diverse mechanisms. Haematologica 102(12):2048-2057, 2017. e-Pub 2017. PMID: 28912176.
- Pan R, Ruvolo V, Mu H, Leverson JD, Nichols G, Reed JC, Konopleva M, Andreeff M. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer Cell 32(6):748-760.e6, 2017. PMID: 29232553.
- Dalton HJ, Pradeep S, McGuire M, Hailemichael Y, Ma S, Lyons Y, Armaiz-Pena GN, Previs RA, Hansen JM, Rupaimoole R, Gonzalez-Villasana V, Cho MS, Wu SY, Mangala LS, Jennings NB, Hu W, Langley R, Mu H, Andreeff M, Bar-Eli M, Overwijk W, Ram P, Lopez-Berestein G, Coleman RL, Sood AK. Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression. Clin Cancer Res 23(22):7034-7046, 2017. e-Pub 2017. PMID: 28855350.
- Huang X, Cao M, Wu S, Wang L, Hu J, Mehran RJ, Roth JA, Swisher SG, Wang RY, Kantarjian HM, Andreeff M, Sun X, Fang B. Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with Inhibitions of cFLIP Expression and PI3K/AKT/mTOR Activities. Oncotarget 8(60):102150-102160, 2017. e-Pub 2017. PMID: 29254232.
- Zhou H, Mak PY, Mu H, Mak DH, Zeng Z, Cortes J, Liu Q, Andreeff M, Carter BZ. Combined inhibition of β-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitorresistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo. Leukemia 31(10):2065-2074, 2017. e-Pub 2017. PMID: 28321124.
- Jacamo R, Davis RE, Ling X, Sonnylal S, Wang Z, Ma W, Zhang M, Ruvolo P, Ruvolo V, Wang RY, McQueen T, Lowe S, Zuber J, Kornblau SM, Konopleva M, Andreeff M. Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia. Oncotarget 8(48):83354-83369, 2017. e-Pub 2017. PMID: 29137349.
- Tu YS, He J, Liu H, Lee HC, Wang H, Ishizawa J, Allen JE, Andreeff M, Orlowski RZ, Davis RE, Yang J. The imipridone ONC201 induces apoptosis and overcomes chemotherapy resistance by upregulation of Bim in multiple myeloma. Neoplasia 19(10):772-780, 2017. e-Pub 2017. PMID: 28863346.
- Daver N, Kantarjian H, Garcia-Manero G, Jabbour E, Borthakur G, Brandt M, Pierce S, Vaughan K, Ning J, Nogueras González GM, Patel K, Jorgensen J, Pemmaraju N, Kadia T, Konopleva M, Andreeff M, DiNardo C, Cortes J, Ward R, Craig A, Ravandi F. Vosaroxin in combination with decitabine in newly diagnosed older patients with acute myeloid leukemia or high-risk MDS. Haematologica 102(10):1709-1717, 2017. e-Pub 2017. PMID: 28729302.
- Zeng Z, Liu W, Tsao T, Qiu Y, Zhao Y, Samudio I, Sarbassov DD, Kornblau SM, Baggerly KA, Kantarjian HM, Konopleva M, Andreeff M. High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia. Haematologica 102(9):1537-1548, 2017. e-Pub 2017. PMID: 28659338.
- Gleixner KV, Schneeweiss M, Eisenwort G, Berger D, Herrmann H, Blatt K, Greiner G, Byrgazov K, Hoermann G, Konopleva M, Waliul I, Cumaraswamy AA, Gunning PT, Maeda H, Moriggl R, Deininger M, Lion T, Andreeff M, Valent P. Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia. Haematologica 102(9):1519-1529, 2017. e-Pub 2017. PMID: 28596283.
- Zhou F, Pan Y, Wei Y, Zhang R, Bai G, Shen Q, Meng S, Le XF, Andreeff M, Claret FX. Jab1/Csn5-thioredoxin signaling in relapsed acute monocytic leukemia under oxidative stress. Clin Cancer Res 23(15):4450-4461, 2017. e-Pub 2017. PMID: 28270496.
- Boddu P, Kantarjian H, Borthakur G, Kadia T, Daver N, Pierce S, Andreeff M, Ravandi F, Cortes J, Kornblau SM. Co-occurrence of FLT3-TKD and NPM1 mutations defines a highly favorable prognostic AML group. Blood Adv 1(19):1546-1550, 2017. e-Pub 2017. PMID: 29296796.
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- Schimmer AD, Thomas MP, Hurren R, Gronda M, Pellecchia M, Pond GR, Konopleva M, Gurfinkel D, Mawji IA, Brown E, Reed JC. Identification of small-molecules that sensitize resistant tumor cells to TNF-family death receptors. Cancer Res 66:2367-2375, 2006.
- Gyurkocza B, Plescia J, Raskett CM, Garlick DS, Lowry PA, Carter BZ, Andreeff M, Meli M, Colombo G, Altieri DC. Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors. J Natl Cancer Inst 98(15):1068-1077, 2006. PMID: 16882944.
- Garzon R, Pichiorri F, Palumbo T, Iuliano R, Cimmino A, Aqeilan R, Volinia S, Bhatt D, Alder H, Marcucci G, Calin GA, Liu CG, Bloomfield CD, Andreeff M, Croce CM. MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci U S A 103(13):5078-5083, 2006. PMID: 16549775.
- Ricciardi MR, McQueen T, Chism D, Milella M, Estey E, Kaldjian E, Sebolt-Leopold J, Konopleva M, Andreeff M. Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia. Leukemia 19(9):1543-1549, 2005. PMID: 16001087.
- Takada Y, Andreeff M, Aggarwal BB. Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 106:641-649, 2005. PMID: 15811958.
- Okcu MF, Wang RY, Bueso-Ramos C, Schober W, Weidner D, Andrassy R, Blakely M, Russell H, Ozkan A, Kuttesch J, Andreeff M, Chan KW, Ater J. Flow cytometry and fluorescence in situ hybridization to detect residual neuroblastoma cells in bone marrow. Pediatr Blood Cancer 45(6):787-795, 2005. PMID: 15929127.
- Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65(8):3307-3318, 2005. PMID: 15833864.
- Milella M, Precupanu CM, Gregorj C, Ricciardi MR, Petrucci MT, Kornblau SM, Tafuri A, Andreeff M. Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects. Curr Pharm Des 11(21):2779-2795, 2005. PMID: 16101455.
- Konopleva M, Contractor R, Kurinna SM, Chen W, Andreeff M, Ruvolo PP. The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells. Leukemia 19(8):1350-1354, 2005. PMID: 15931262.
- Kojima K, Konopleva M, Samudio IJ, Shikami M, Cabreira-Hansen M, McQueen T, Ruvolo V, Tsao T, Zeng Z, Vassilev LT, Andreeff M. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood 106(9):3150-3159, 2005. PMID: 16014563.
- Keating MJ, O'Brien S, Albitar M, Lerner S, Plunkett W, Giles F, Andreeff M, Cortes J, Faderl S, Thomas D, Koller C, Wierda W, Detry MA, Lynn A, Kantarjian H. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 23(18):4079-4088, 2005. PMID: 15767648.
- Jabbour E, Verstovsek S, Giles F, Gandhi V, Cortes J, O'Brien S, Plunkett W, Garcia-Manero G, Jackson CE, Kantarjian H, Andreeff M. 2-Chlorodeoxyadenosine and cytarabine combination therapy for idiopathic hypereosinophilic syndrome. Cancer 104(3):541-546, 2005. PMID: 15977212.
- Georgakis GV, Li Y, Humphreys R, Andreeff M, O'Brien S, Younes M, Carbone A, Albert V, Younes A. Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. Br J Haematol 130(4):501-510, 2005. PMID: 16098063.
- Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia. Cancer Res 65(7):2890-2898, 2005. PMID: 15805291.
- Chintharlapalli, S, Papineni S, Konopleva M, Andreeff M, Samudio I, Safe S. 2-cyano-3,12-dioxoolean-1,9-dien-28 oic acid (CDDO) and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor-g-dependent and –independent pathways. . Mol Pharmacol 68(1):119-128, 2005.
- Carter BZ, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Pond GR, Mawji IA, Houghten RA, Ostresh J, Brandwein J, Minden MD, Schuh AC, Wells RA, Messner H, Chun K, Reed JC, Schimmer AD. Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. Blood 105(10):4043-4050, 2005. PMID: 15687241.
- Biagi E, Rousseau R, Yvon E, Schwartz M, Dotti G, Foster A, Havlik-Cooper D, Grilley B, Gee A, Baker K, Carrum G, Rice L, Andreeff M, Popat U, Brenner M. Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia. Clin Cancer Res 11(19 Pt 1):6916-6923, 2005. PMID: 16203783.
- Zhang W, McQueen T, Schober W, Rassidakis G, Andreeff M, Konopleva M. Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. Leukemia 19(11):1977-1984, 2005. PMID: 16151469.
- Samudio I, Konopleva M, Safe S, McQueen T, Andreeff M. Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Mol Cancer Ther 4(12):1982-1992, 2005. PMID: 16373713.
- Konopleva M, Shi Y, Steelman LS, Shelton JG, Munsell M, Marini F, McQueen T, Contractor R, McCubrey JA, Andreeff M. Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells. Cancer Res 65(21):9962-9970, 2005. PMID: 16267021.
- Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J Biol Chem 280(43):36273-36282, 2005. PMID: 16118208.
Abstracts
- Pourebrahim R, Montoya RH, Alaniz Z, Ostermann L, Lin PP, Liu B, Ayoub E, Burks JK, Andreeff M. Mdm2/p53 levels in bone marrow mesenchymal stromal cells is essential for maintaining the hematopoietic niche in response to DNA damage. Res Sq, 2023. e-Pub 2023. PMID: 36909480.
- Beryozkina A, Zhi J, Nichols G, Reckner M, Vassilev RL, Ruediger, Andreeff M, Padmanabhan S, Strair R, Kirschbaum M, Maslak P, Hillmen P, Gore L, Patnaik A, Sarapa N. Pharmacokinetics (PK) and pharmacodynamics (PD) of RG7112, an oral murine double minute 2 (MDM2) antagonist, in patients with leukemia and solid tumor. ASCO 2011, 2011.
Grant & Contract Support
Title: | The Therapy of CML (Project 3: Targeting microenvironment / leukemia cell interactions in CML) |
Funding Source: | NIH/NCI |
Role: | Project Leader |
Title: | The Therapy of AML Project 4: Clinical Trials in AML |
Funding Source: | NIH/NCI |
Role: | Co-Project Leader |
Title: | The Therapy of AML Core D: Administrative Core |
Funding Source: | NIH/NCI |
Role: | Core Leader |
Title: | Ovarian SPORE Project 5: Gene-modified MSCs for Control of Ovarian Cancer |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | 2007-0408: A Multi-Center, Open-Label, Phase I CT Study of Single Agent RO5045337 (R) Administered Orally Once Daily (D) x 10 Days Followed by 18 Days of Rest, or Once Every Other Day |
Funding Source: | Hoffmann-LaRoche |
Role: | Principal Investigator |
Title: | The Therapy of AML Core B1: Fluorescence-Activated Cell Sorting (FACS/Molecular Cytogenetics (FISH)/Confocal Microscopy |
Funding Source: | NIH/NCI |
Role: | Core Leader |
Title: | Targeting Breast Cancer Stem Cells |
Funding Source: | Breast Cancer Research Foundation |
Role: | Principal Investigator |
Title: | Therapeutic potential of new HDM2 inhibitor and possible synergism with FLT3 inhibition |
Funding Source: | Daiichi-Sankyo, Inc |
Role: | Principal Investigator |
Title: | Regulation and Targeting of GD2+ Breast Cancer Stem-Like Cells - Project 2 |
Funding Source: | Institutional Support, Multidisciplinary Research Program |
Role: | Principal Investigator |
Title: | Preclinical Characterization of Combinatorial Anti-leukemic Effects of MDM2 Antagonist RG7112/RG7388 and BCL2 Inhibitor ABT-199 |
Funding Source: | Roche/Genentech and AbbVie |
Role: | Principal Investigator |
Title: | Anti-leukemia effects of anti-FLT3-ADC in AML with FLT3 mutations |
Funding Source: | Symphogen |
Role: | Principal Investigator |
Title: | Targeting cMet in the Micro-environment of Acute Myeloid Leukemia Stem Cells |
Funding Source: | Merck/Serono |
Role: | Principal Investigator |
Title: | Leukemia SPORE DRP (Combined Blockade of MDM2 and XPO1 in Acute Myeloid Leukemia) |
Funding Source: | NIH/NCI |
Role: | Project Leader |
Title: | Cancer Center Support Grant (CCSG): Shared Resource-Flow Cytometry and Cellular Imaging Facility |
Funding Source: | NIH/NCI |
Role: | Core Leader |
Title: | Cancer Center Support (Core) Grant: Hematologic Malignancies |
Funding Source: | NIH/NCI |
Role: | Co-Program Leader |
Title: | Targeting AML MRD/Stem Cells in Poor Prognosis AML |
Funding Source: | MDACC Moon Shot Program |
Role: | Principal Investigator |
Title: | Myeloma Moon Shot Project 6 |
Funding Source: | MDACC Moon Shot Program |
Role: | Co-Principal Investigator |
Title: | A Phase 1 dose escalation study of DS-3032b, an oral MDM2 inhibitor, in subjects with acute myelogenous leukemia, acute lymphocytic |
Funding Source: | Daiichi-Sankyo |
Role: | Principal Investigator |
Title: | Biomarkers for Clinical Study of E6201 in FLT3 mutated patients with advanced hematologic malignancies, including AML |
Funding Source: | Boston Strategics |
Role: | Principal Investigator |
Title: | Anti-GD2 Therapy in Breast Cancer Prevention |
Funding Source: | United Therapeutics |
Role: | Co-Investigator |
Title: | Olympus IX83 confocal microscope with Andor DUal Camera |
Funding Source: | MDACC Tech Task Force |
Role: | Principal Investigator |
Title: | Personalized therapy for AML patients with a newly identified genetic alteration |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | 2014-0975 Phase I/II Investigator Sponsored Study of Selinexor (KPT-330), a Selective Inhibitor of Nuclear Export / SINE™ Compound + Sorafenib in Acute Myeloid Leukemia |
Funding Source: | Karyopharm |
Role: | Principal Investigator |
Title: | CCSG Capital Equipment Award |
Funding Source: | CCSG Internal Award |
Role: | Principal Investigator |
Title: | Southwest Early Clinical Trials Consortium - Targeting E-Selectin with GMI-1271 to Overcome Microenvironment-mediated Resistance to Venetoclax/HMA in AML |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Strategic Alliance: Concomitant targeting of E-selectin and G-CSF increases efficacy of FLT3-targeted therapy with quizartinib in acute myeloid leukemia |
Funding Source: | Daiichi-Sankyo, Inc |
Role: | Co-Principal Investigator |
Title: | Combinatorial Inhibition of MDM2 and XPO1 in AML |
Funding Source: | Daiichi-Sankyo, Inc |
Role: | Co-Principal Investigator |
Title: | Therapeutic targeting of p53 reactivation-induced OXPHOS dependency and stress responses to overcome resistance to venetoclax/HMA in AML |
Funding Source: | NIH/NCI |
Role: | Principal Investigator |
Title: | Strategic Alliance: LAB02-395 Direct comparison of DS-3201 (EZH1/2 inhibitor) vs. EZH2 single inhibitor and Targeting EZH1/2 in normal hematopoiesis |
Funding Source: | Daiichi-Sankyo, Inc |
Role: | Principal Investigator |
Title: | Identifying, Understanding, and Eradicating Measurable Residual Disease (MRD) in Patients with Acute Myeloid Leukemia (AML) |
Funding Source: | Break Through Cancer |
Role: | Co-Principal Investigator |
Title: | Investigation of Anti-leukemia Efficacy of the Dual FLT3/Aurora Kinase Inhibitor EP0042 in FLT3 Mutated Acute Myelogenous Leukemias, and Evaluation of Combinatorial Efficacy of EP0042 + Venetoclax (or Ven/HMA) for FLT3-inhibitor-resistent Cells |
Funding Source: | Ellipses Pharma Lmited |
Role: | Principal Investigator |
Title: | IPS-derived MSC (iMSC) Homing to Bone Marrow and Evaluation for Support of Hematopoiesis |
Funding Source: | Eterna (formerly BrooklynITX) |
Role: | Principal Investigator |
Title: | Preclinical study of PC14568 in TP53-Y220C mutant AML/MDS |
Funding Source: | PMV Pharmaceuticals, Inc |
Role: | Principal Investigator |
Title: | Assessment of Leukemia Proteomic Landscape to Optimize Immunotherapeutic Approaches in Acute Myeloid Leukemia |
Funding Source: | AstraZeneca |
Role: | Principal Investigator |
Title: | Rewiring Cancer Metabolism by Targeting MYC Proteins in MYC‐driven Hematologic Malignancies |
Funding Source: | UT Austin/MD Anderson Cancer Center Collaborative Pilot Project Grant |
Role: | Principal Investigator |
Title: | Targeting Ferroptosis and Mitochondrial Pathways in Acute Myeloid Leukemia |
Funding Source: | Department of Defense (DOD) |
Role: | Other Significant Contributor |
Title: | Synergistic Induction of Ferroptosis and Mitochondrial Cell Death in Acute Myeloid Leukemia |
Funding Source: | Department of Defense (DOD) |
Role: | Other Significant Contributor |
Title: | Targeting AML Mitochondria by Ceramide |
Funding Source: | NIH/NCI / Lipo-Immuno Tech, LLC |
Role: | Co-Investigator |
Title: | Ph1/2 Study of the Imipridone ONC201 for Treatment of AML IND125,203 (12/23/2014) |
Funding Source: | Food and Drug Administration (FDA) |
Role: | Principal Investigator |
Title: | Evaluating Therapeutic Potentials of c-Myc Degrader GT19715 in TP53-mutant and venetoclax/HMA resistant Acute Myeloid Leukemia and Minimal Residual Disease |
Funding Source: | Kintor Pharma |
Role: | Principal Investigator |
Title: | Targeting SHP2 signaling to enhance BH3 mimetic therapy in AML |
Funding Source: | Revolution Medicine |
Role: | Co-Principal Investigator |
Title: | Assessment of 5T4 and Other Protein Expression in AML, CMML and MDS |
Funding Source: | Oxford Biomedica (UK) Limited |
Role: | Principal Investigator |
Title: | Strategic Alliance: Targeting EZH1/2 activity to overcome chemo/epigenetic therapy-resistance in AML |
Funding Source: | Daiichi Sankyo, Inc |
Role: | Principal Investigator |
Title: | Strategic Alliance: Optimized concept of eradicating dormant LSC by restoring chemosensitivity by EZH1/2 inhibition |
Funding Source: | Daiichi Sankyo, Inc |
Role: | Principal Investigator |
Title: | Strategic Alliance: Investigate the therapeutic potential of Mcl-1 inhibition alone and combined with other therapeutic agents in AML |
Funding Source: | Amgen |
Role: | Co-Investigator |
Title: | Targeting the mitochondrial protease ClpP, as a novel therapeutic strategy for AML |
Funding Source: | Leukemia and Lymphoma Society |
Role: | Principal Investigator |
Title: | Southwest Early Clinical Trials Consortium - Therapeutic Targeting of DNA-PKcs in combination with CPX-351 in acute myeloid leukemia |
Funding Source: | NIH/NCI |
Role: | Co-Investigator |
Title: | Continuation of studies to investigate efficacy of AXL inhibitor strategy for AML therapy using ONO-9330547 (now known as ONO-7475) |
Funding Source: | ONO Pharmaceuticals |
Role: | Co-Investigator |
Title: | ONO-9330547 as a novel strategy for targeting leukemic cells within their BM microenvironment |
Funding Source: | ONO Pharmaceuticals |
Role: | Co-Investigator |
Title: | To investigate the potential of combined MDM2 inhibition and Bcr-Abl tyrosine kinase inhibition on eliminating CML stem cells and curing CML in vivo |
Funding Source: | Daiichi-Sankyo |
Role: | Co-Investigator |
Title: | Quantification ofH3K27me31evel and Leukemic Stem Cell population in AML cell lines models and samples from patients with Relapse/Refractory AML |
Funding Source: | Daiichi-Sankyo |
Role: | Principal Investigator |
Title: | CCSG Capital Equipment Award |
Funding Source: | CCSG Internal Award |
Role: | Principal Investigator |
Title: | Flagship Project: Targeting Minimal Residual Disease and Stem-like Cells in High-Risk AML |
Funding Source: | MDACC Moon Shot Program |
Role: | Principal Investigator |
Title: | Acute Myeloid Leukemia in the Immunosuppressed Microenvironment |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | Principal Investigator |
Title: | A U. T. System Proteomics Core Facility Network |
Funding Source: | University of Texas System |
Role: | Project Leader |
Title: | The Therapy of AML |
Funding Source: | NIH/NCI |
Role: | Principal Investigator |
Title: | Effects of HIF-1alpha inhibition by EZN2968 on human leukemias |
Funding Source: | Enzon |
Role: | Principal Investigator |
Title: | The Therapy of AML Project 1: Targeting Regulators of Apoptosis in AML |
Funding Source: | NIH/NCI |
Role: | Principal Investigator |