Michael T. Spiotto, MD, PhD
Department of Radiation Oncology, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2005 | The University of Chicago, Chicago, Illinois, US, Medicine, MD |
| 2003 | The University of Chicago, Chicago, Illinois, US, Pathology, Ph.D |
| 1998 | The University of Chicago, Chicago, Illinois, US, Biological Chemistry, BS |
Postgraduate Training
| 2006-2010 | Clinical Residency, Radiation Oncology, Stanford University, Stanford, California |
| 2005-2006 | Transitional Internship, Memorial Sloan Kettering Cancer Center, New York, New York |
| 2000-2005 | MD, PhD Training Program, Growth and Development Training Program, The University of Chicago, Chicago, Illinois |
Board Certifications
| 2011 | The American Board of Radiology |
Experience & Service
Academic Appointments
Associate Professor, The University of Chicago, Chicago, IL, 2018 - 2020
Assistant Professor, The University of Chicago, Chicago, IL, 2012 - 2018
Other Appointments/Responsibilities
Instructor, Department of Radiation & Cellular Oncology, The University of Chicago, Chicago, IL, 2010 - 2012
Lecturer, Department of Radiation Oncology, The University of Illinois Hospitals and Clinics, Chicago, IL, 2001 - 2002
Institutional Committee Activities
Member, ASTRO, 2020 - 2022
Member, Committee on Cancer Biology, University of Chicago, 2010 - 2020
Honors & Awards
| 2023 - Present | Fiscal Year 2023: M.D. Anderson Top 1% Providers, The University of Texas MD Anderson Cancer Center |
| 2022 - Present | Fiscal Year 2022: M.D. Anderson Top 10% Providers, The University of Texas MD Anderson Cancer Center |
| 2018 - 2019 | Top Doctors, Castle Connolly |
| 2017 | Top Cancer Doctors, Chicago Magazine |
| 2013 | Best Abstract Award, American Society for Therapeutic Radiation Oncology 2013 Annual Meeting |
| 2009 | Martin J. Brown Award for Radiation Oncology Research, Stanford University |
| 2009 | Roentgen Resident/Fellow Research Award, Stanford University |
| 2008 | Malcolm Bagshaw Award, Stanford University |
| 2007 - 2010 | Holman Research Pathway Selection, Stanford University |
| 2005 | John Van Prohaska Award for Outstanding Potential in Teaching, Research, and Clinical Medicine, The University of Chicago |
| 2005 | Leon O. Jacobson Basic Science Prize, The University of Chicago |
| 2004 | Alpha Omega Alpha, The University of Chicago |
| 2003 | Award for Best Dissertation, Department of Pathology, The University of Chicago |
| 2003 | Robert Priest Award in Pathology, The University of Chicago |
| 2003 | Keystone Symposia Travel Scholarship, Keystone |
| 1999 | Young Investigator Travel Grant, American Association for Cancer Research |
| 1998 | Divisional Honors, The University of Chicago |
| 1998 | General Honors, The University of Chicago |
| 1994 - 1998 | Dean’s List, The University of Chicago |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Humbert-Vidan, L, Kamel, S, Wentzel, A, Kaffey, Z, Abdelaal, MA, Spier, KB, West, NA, Marai, EG, Canahuate, GM, Zhang, X, Chen, MM, Wahid, K, Rigert, J, Hosseinian, S, Schaefer, AJ, Brock, K, Chambers, MS, Otun, AO, Aponte Wesson, R, Patel, V, Hope, A, Phan, J, Garden, AS, Frank, SJ, Morrison, WH, Spiotto, MT, Rosenthal, D, Lee, A, He, R, Naser, M, Watson, E, Hutcheson, KA, Mohamed, AS, Sandulache, VC, van Dijk, L, Moreno, AC, Guerrero Urbano, T, Fuller, C, Lai, SY. Externally validated digital decision support tool for time-to-osteoradionecrosis risk-stratification using right-censored multi-institutional observational cohorts. Radiotherapy and Oncology 207, 2025. e-Pub 2025. PMID: 40222595.
- Goodman CD, DeMonte F, Nguyen TP, Garden AS, Wang CH, Wang XA, Diao K, Lee A, Reddy J, Moreno A, Spiotto M, Fuller CD, Rosenthal D, Ferrarotto R, Raza SM, Su SY, Warner A, Hanna E, Phan J. A prospective cohort study on stereotactic radiotherapy in the management of dural recurrence of olfactory neuroblastoma. Head Neck 47(1):81-89, 2025. e-Pub 2024. PMID: 39073252.
- Bronk, JK, Augustyn, A, Mohamed, AS, Fuller, C, Garden, AS, Moreno, AC, Lee, A, Morrison, WH, Phan, J, Reddy, JP, Rosenthal, DI, Spiotto, MT, Frank, SJ, Dadu, R, Busaidy, NL, Zafereo, M, Wang, RJ, Maniakas, A, Ferrarotto, R, Iyer, PC, Cabanillas, ME, Gunn, GB. Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer. Radiotherapy and Oncology 202, 2025. e-Pub 2025. PMID: 39489425.
- Hamidi S, Dadu R, Zafereo ME, Ferrarotto R, Wang JR, Maniakas A, Gunn GB, Lee A, Spiotto MT, Iyer PC, Sousa LG, Akhave NS, Ahmed S, Learned KO, Lu C, Lai SY, Williams M, Hosseini SM, Busaidy NL, Cabanillas ME. Initial Management of BRAF V600E-Variant Anaplastic Thyroid Cancer: The FAST Multidisciplinary Group Consensus Statement. JAMA Oncol 10(9):1264-1271, 2024. e-Pub 2024. PMID: 38990526.
- Islam S, Gleber-Netto FO, Mulcahy CF, Glaun MDE, Srivastava S, Hunt PJ, Williams MD, Barbon CE, Spiotto M, Zhao W, Adebayo A, Akhter S, Xie T, Debnath KC, Sathishkumar HN, Myers B, Lothumalla S, Yaman I, Burks JK, Gomez J, Rao X, Wang J, Woodman K, Mansour J, Arenkiel B, Osman KL, Haxton C, Lever TE, Hutcheson KA, Amit M. Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma. Sci Transl Med 16(758):eabq5585, 2024. e-Pub 2024. PMID: 39083586.
- Siqueira JM, Mitani Y, Hoff CO, Bonini F, Guimaraes de Sousa L, Marques-Piubelli ML, Purushothaman A, Mitani M, Dai H, Lin SY, Spiotto MT, Hanna EY, McGrail DJ, El-Naggar AK, Ferrarotto R. Analysis of B7-H4 Expression Across Salivary Gland Carcinomas Reveals Adenoid Cystic Carcinoma-Specific Prognostic Relevance. Mod Pathol 37(1):100371, 2024. e-Pub 2024. PMID: 38015043.
- Maroongroge S, Mohamed AS, Nguyen C, Guma De la Vega J, Frank SJ, Garden AS, Gunn BG, Lee A, Mayo L, Moreno A, Morrison WH, Phan J, Spiotto MT, Court LE, Fuller CD, Rosenthal DI, Netherton TJ. Clinical acceptability of automatically generated lymph node levels and structures of deglutition and mastication for head and neck radiation therapy. Phys Imaging Radiat Oncol 29:100540, 2024. e-Pub 2024. PMID: 38356692.
- Contrera KJ, Phan J, Waguespack SG, Aldehaim M, Wang X, Lim TY, Roberts DB, Fuller CD, Spiotto MT, Raza SM, DeMonte F, Hanna EY, Su SY. Prevalence of pituitary hormone dysfunction following radiotherapy for sinonasal and nasopharyngeal malignancies. Head Neck 45(10):2525-2532, 2023. e-Pub 2023. PMID: 37534890.
- Salama, V, Youssef, S, Xu, T, Wahid, K, Chen, J, Rigert, J, Lee, A, Hutcheson, KA, Gunn, GB, Phan, JL, Garden, AS, Frank, SJ, Morrison, W, Reddy, JP, Spiotto, MT, Naser, M, Dede, C, He, R, Mohamed, AS, van Dijk, L, Lin, R, Roldan, C, Rosenthal, DI, Fuller, C, Moreno, AC. Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study. Oral Oncology Reports 7, 2023. e-Pub 2023. PMID: 38638130.
- Zhao X, Wang JR, Dadu R, Busaidy NL, Xu L, Learned KO, Chasen NN, Vu T, Maniakas A, Eguia AA, Diersing J, Gross ND, Goepfert R, Lai SY, Hofmann MC, Ferrarotto R, Lu C, Gunn GB, Spiotto MT, Subbiah V, Williams MD, Cabanillas ME, Zafereo ME. Surgery after BRAF-directed therapy is associated with improved survival in BRAF V600E mutant Anaplastic Thyroid Cancer. Thyroid 33(4):484-491, 2023. e-Pub 2023. PMID: 36762947.
- Ganesh A, Korpics M, Pasquinelli M, Feldman L, Spiotto MT, Koshy M. Increased Utilization of Stereotactic Body Radiotherapy is Associated with Decreased Disparities and Improved Survival for Early-Stage NSCLC. Clinical Lung Cancer 24(1):60-71, 2023. e-Pub 2022. PMID: 36289032.
- Korpics MC, Turchan WT, Koshy M, Spiotto MT. Decreased overall survival in patients with locally advanced head and neck cancer receiving definitive radiotherapy and concurrent cetuximab: National Cancer Database analysis. Head Neck 44(7):1528-1544, 2022. e-Pub 2022. PMID: 35393753.
- Ganesh A, Katipally R, Pasquinelli M, Feldman L, Spiotto MT, Koshy M. Increased Disparities in Patients Diagnosed with Metastatic Lung Cancer Following Lung CT Screening in the United States. Clinical Lung Cancer 23(2):151-158, 2022. e-Pub 2022. PMID: 34924304.
- Ni K, Xu Z, Culbert A, Luo T, Guo N, Yang K, Pearson E, Preusser B, Wu T, La Riviere P, Weichselbaum RR, Spiotto MT, Lin W. Synergistic checkpoint-blockade and radiotherapy-radiodynamic therapy via an immunomodulatory nanoscale metal-organic framework. Nature Biomedical Engineering 6(2):144-156, 2022. e-Pub 2022. PMID: 35190678.
- van Dijk LV, Frank SJ, Yuan Y, Gunn B, Moreno AC, Mohamed ASR, Preston KE, Qing Y, Spiotto MT, Morrison WH, Lee A, Phan J, Garden AS, Rosenthal DI, Langendijk JA, Fuller CD. Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients [PIRATES]: A Phase I safety and feasibility trial of MRI-guided adaptive particle radiotherapy. Clinical and Translational Radiation Oncology 32:35-40, 2022. e-Pub 2022. PMID: 34841093.
- Guo N, Ni K, Luo T, Lan G, Arina A, Xu Z, Mao J, Weichselbaum RR, Spiotto MT, Lin W. Reprogramming of Neutrophils as Non-canonical Antigen Presenting Cells by Radiotherapy-Radiodynamic Therapy to Facilitate Immune-Mediated Tumor Regression. ACS Nano 15(11):17515-17527, 2021. e-Pub 2021. PMID: 34709030.
- Diao K, Nguyen TP, Moreno AC, Reddy JP, Garden AS, Wang CH, Tung S, Wang C, Wang XA, Rosenthal DI, Fuller CD, Gunn GB, Frank SJ, Morrison WH, Shah SJ, Lee A, Spiotto MT, Su SY, Ferrarotto R, Phan J. Stereotactic body ablative radiotherapy for reirradiation of small volume head and neck cancers is associated with prolonged survival: Large, single-institution, modern cohort study. Head Neck 43(11):3331-3344, 2021. e-Pub 2021. PMID: 34269492.
- Turchan, WT, Korpics, MC, Rooney, MK, Koshy, M, Spiotto, MT. Impact of anatomic site of distant metastasis on survival in salivary gland cancers. Head and Neck 43(9):2589-2601, 2021. e-Pub 2021. PMID: 33961718.
- Rooney, MK, Korpics, MC, Turchan, WT, Callahan, N, Koshy, M, Spiotto, MT. Patterns of Care and Survival Outcomes for Odontogenic Cancers. Laryngoscope 131(5):E1496-E1502, 2021. e-Pub 2021. PMID: 33135786.
- Turchan, WT, Gutiontov, SI, Spiotto, MT, Liauw, SL. Prostate Cancer Radiotherapy. JNCI Cancer Spectrum 4(6), 2021. e-Pub 2021. PMID: 33409456.
- Spiotto MT, McGovern SL, Gunn GB, Grosshans D, McAleer MF, Frank SJ, Paulino AC. Proton Radiotherapy to Reduce Late Complications in Childhood Head and Neck Cancers. International Journal of Particle Therapy 8(1):155-167, 2021. e-Pub 2021. PMID: 34285943.
- Böttinger P, Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Willimsky G, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Leisegang M, Schreiber H. Cooperation of genes in HPV16 E6/E7-dependent cervico-vaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. Carcinogenesis 41(11):1605-1615, 2020. e-Pub 2020. PMID: 32221533.
- Howard FM, Kochanny S, Koshy M, Spiotto MT, Pearson AT. Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer. JAMA Netw Open 3(11):e2025881, 2020. e-Pub 2020. PMID: 33211108.
- Foster CC, Seiwert TY, MacCracken E, Blair EA, Agrawal N, Melotek JM, Portugal L, Brisson RJ, Gooi Z, Spiotto MT, Vokes EE, Haraf DJ. Dose and Volume De-Escalation for Human Papillomavirus-Positive Oropharyngeal Cancer is Associated with Favorable Posttreatment Functional Outcomes. Int J Radiat Oncol Biol Phys 107(4):662-671, 2020. e-Pub 2020. PMID: 32311416.
- Hasan Y, Furtado L, Tergas A, Lee N, Brooks R, McCall A, Golden D, Jolly S, Fleming G, Morrow M, Kraynyak K, Sylvester A, Arif F, Levin M, Schwartz D, Boyer J, Skolnik J, Esser M, Kumar R, Bagarazzi M, Weichselbaum R, Spiotto M. A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer. Int J Radiat Oncol Biol Phys 107(3):487-498, 2020. e-Pub 2020. PMID: 32151670.
- Spiotto MT, Koshy M. The Risk Is Worth the Reward: Regional-Only Recurrence Is Curable with Nodal Dissection. Int J Radiat Oncol Biol Phys 106(2):239-240, 2020. e-Pub 2020. PMID: 31928639.
- Korpics MC, Turchan WT, Rooney MK, Koshy M, Spiotto MT. Patterns of Care and Outcomes of Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy for Early Stage Glottic Cancer: A National Cancer Database Analysis. Cancers (Basel) 11(12), 2019. e-Pub 2019. PMID: 31842271.
- Ricco N, Flor A, Wolfgeher D, Efimova EV, Ramamurthy A, Appelbe OK, Brinkman J, Truman AW, Spiotto MT, Kron SJ. Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer. Mol Oncol 13(9):1927-1943, 2019. e-Pub 2019. PMID: 31225926.
- Foster CC, Rusthoven CG, Sher DJ, Feldman L, Pasquinelli M, Spiotto MT, Koshy M. Corrigendum to "Adjuvant chemotherapy following stereotactic body radiotherapy for early stage non-small-cell lung cancer is associated with lower overall survival: A National Cancer Database Analysis" [Lung Cancer, Volume 130 (April) (2019) 162-168]. Lung Cancer 132:159, 2019. e-Pub 2019. PMID: 31031052.
- Foster CC, Rusthoven CG, Sher DJ, Feldman L, Pasquinelli M, Spiotto MT, Koshy M. Adjuvant chemotherapy following stereotactic body radiotherapy for early stage non-small-cell lung cancer is associated with lower overall: A National Cancer Database Analysis. Lung Cancer 130:162-168, 2019. e-Pub 2019. PMID: 30885339.
- Huang L, David O, Cabay RJ, Valyi-Nagy K, Macias V, Zhong R, Wenig B, Feldman L, Weichselbaum R, Spiotto MT. Molecular Classification of Lymph Node Metastases Subtypes Predict for Survival in Head and Neck Cancer. Clin Cancer Res 25(6):1795-1808, 2019. e-Pub 2019. PMID: 30573692.
- Foster CC, Sher DJ, Rusthoven CG, Verma V, Spiotto MT, Weichselbaum RR, Koshy M. Overall survival according to immunotherapy and radiation treatment for metastatic non-small-cell lung cancer: a National Cancer Database analysis. Radiat Oncol 14(1):18, 2019. e-Pub 2019. PMID: 30691492.
- Lu K, He C, Guo N, Chan C, Ni K, Lan G, Tang H, Pelizzari C, Fu YX, Spiotto MT, Weichselbaum RR, Lin W. Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy. Nat Biomed Eng 2(8):600-610, 2018. e-Pub 2018. PMID: 31015630.
- Koshy M, Sher DJ, Spiotto MT, Husain Z, Engelhard H, Slavin K, Nicholas MK, Weichselbaum RR, Rusthoven C. Association between hospital volume and receipt of treatment and survival in patients with glioblastoma. J Neurooncol 135(3):529-534, 2017. e-Pub 2017. PMID: 28836140.
- Spiotto MT, Jefferson GD, Wenig B, Markiewicz MR, Weichselbaum RR, Koshy M. Survival outcomes for postoperative chemoradiation in intermediate-risk oral tongue cancers. Head Neck 39(12):2537-2548, 2017. e-Pub 2017. PMID: 28960621.
- Spiotto MT, Jefferson G, Wenig B, Markiewicz M, Weichselbaum RR, Koshy M. Differences in Survival With Surgery and Postoperative Radiotherapy Compared With Definitive Chemoradiotherapy for Oral Cavity Cancer: A National Cancer Database Analysis. JAMA Otolaryngol Head Neck Surg 143(7):691-699, 2017. e-Pub 2017. PMID: 28426848.
- Koshy M, Malik R, Spiotto MT, Mahmood U, Rusthoven CG, Sher DJ. Association between intensity modulated radiotherapy and survival in patients with stage III non-small cell lung cancer treated with chemoradiotherapy. Lung Cancer 108:222-227, 2017. e-Pub 2017. PMID: 28625640.
- Spiotto MT, Koshy M. Impact of fraction size on locally advanced oropharyngeal and nasopharyngeal cancers treated with chemoradiation. Oral Oncol 68:27-35, 2017. e-Pub 2017. PMID: 28438289.
- Melotek JM, Cooper BT, Koshy M, Silverman JS, Spiotto MT. Weekly versus every-three-weeks platinum-based chemoradiation regimens for head and neck cancer. J Otolaryngol Head Neck Surg 45(1):62, 2016. e-Pub 2016. PMID: 27881143.
- Spiotto MT. Return of induction chemotherapy in head and neck squamous cell cancers: is this time different?. Lancet Oncol 17(11):1465-1467, 2016. e-Pub 2016. PMID: 27686944.
- Spiotto MT, Fu YX, Weichselbaum RR. The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications. Sci Immunol 1(3), 2016. e-Pub 2016. PMID: 28018989.
- Zheng W, Skowron KB, Namm JP, Burnette B, Fernandez C, Arina A, Liang H, Spiotto MT, Posner MC, Fu YX, Weichselbaum RR. Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance. Oncotarget 7(28):43039-43051, 2016. e-Pub 2016. PMID: 27343548.
- Jefferson GD, Wenig BL, Spiotto MT. Predictors and outcomes for chronic tracheostomy after chemoradiation for advanced laryngohypopharyngeal cancer. Laryngoscope 126(2):385-91, 2016. e-Pub 2016. PMID: 26344401.
- Bechill J, Zhong R, Zhang C, Solomaha E, Spiotto MT. A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53. PLoS One 11(4):e0154125, 2016. e-Pub 2016. PMID: 27124407.
- Zhong R, Bechill J, Spiotto MT. Loss of E2F1 Extends Survival and Accelerates Oral Tumor Growth in HPV-Positive Mice. Cancers (Basel) 7(4):2372-85, 2015. e-Pub 2015. PMID: 26670255.
- Spiotto MT, Koshy M. Hospitalizations of more than 5 days predict for worse outcomes after radiotherapy for head and neck cancer. J Community Support Oncol 13(10):367-73, 2015. e-Pub 2015. PMID: 26862912.
- Zhong R, Bao R, Faber PW, Bindokas VP, Bechill J, Lingen MW, Spiotto MT. Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis. Cancer Res 75(18):3958-3969, 2015. e-Pub 2015. PMID: 26294213.
- Spiotto MT, Cao H, Mell L, Toback FG. Angiotensin-converting enzyme inhibitors predict acute kidney injury during chemoradiation for head and neck cancer. Anticancer Drugs 26(3):343-9, 2015. e-Pub 2015. PMID: 25486599.
- Koshy M, Malik R, Sher DJ, Spiotto M, Mahmood U, Aydogan B, Weichselbaum RR. The effect of radiotherapy dose on survival in stage III non-small-cell lung cancer patients undergoing definitive chemoradiotherapy. Clin Lung Cancer 15(5):365-71, 2014. e-Pub 2014. PMID: 24984565.
- Zhong R, Pytynia M, Pelizzari C, Spiotto MT. Bioluminescent imaging of HPV-positive oral tumor growth and its response to image-guided radiotherapy. Cancer Res 74(7):2073-81, 2014. e-Pub 2014. PMID: 24525739.
- Rudra S, Spiotto MT, Witt ME, Blair EA, Stenson K, Haraf DJ. Lymph node density--prognostic value in head and neck cancer. Head Neck 36(2):266-72, 2014. e-Pub 2014. PMID: 23765406.
- Liu GF, Ranck MC, Solanki AA, Cao H, Kolokythas A, Wenig BL, Chen L, Ard S, Weichselbaum RR, Halpern H, Spiotto MT. Racial parities in outcomes after radiotherapy for head and neck cancer. Cancer 120(2):244-52, 2014. e-Pub 2014. PMID: 24122486.
- Ranck MC, Abundo R, Jefferson G, Kolokythas A, Wenig BL, Weichselbaum RR, Spiotto MT. Effect of postradiotherapy neck dissection on nonregional disease sites. JAMA Otolaryngol Head Neck Surg 140(1):12-21, 2014. e-Pub 2014. PMID: 24263403.
- Zakeri K, MacEwan I, Vazirnia A, Cohen EE, Spiotto MT, Haraf DJ, Vokes EE, Weichselbaum RR, Mell LK. Race and competing mortality in advanced head and neck cancer. Oral Oncol 50(1):40-4, 2014. e-Pub 2014. PMID: 24134948.
- Herman LC, Chen L, Garnett A, Feldman LE, Smith B, Weichselbaum RR, Spiotto MT. Comparison of carboplatin-paclitaxel to docetaxel-cisplatin-5-flurouracil induction chemotherapy followed by concurrent chemoradiation for locally advanced head and neck cancer. Oral Oncol 50(1):52-8, 2014. e-Pub 2014. PMID: 24055193.
- Spiotto MT, Weichselbaum RR. Comparison of 3D confromal radiotherapy and intensity modulated radiotherapy with or without simultaneous integrated boost during concurrent chemoradiation for locally advanced head and neck cancers. PLoS One 9(4):e94456, 2014. e-Pub 2014. PMID: 24714187.
- Schreiber K, Arina A, Engels B, Spiotto MT, Sidney J, Sette A, Karrison TG, Weichselbaum RR, Rowley DA, Schreiber H. Spleen cells from young but not old immunized mice eradicate large established cancers. Clin Cancer Res 18(9):2526-33, 2012. e-Pub 2012. PMID: 22415314.
- Spiotto MT, Banh A, Papandreou I, Cao H, Galvez MG, Gurtner GC, Denko NC, Le QT, Koong AC. Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res 70(1):78-88, 2010. e-Pub 2010. PMID: 20028872.
- King CR, Spiotto MT, Kapp DS. Obesity and risk of biochemical failure for patients receiving salvage radiotherapy after prostatectomy. Int J Radiat Oncol Biol Phys 73(4):1017-22, 2009. e-Pub 2009. PMID: 18707829.
- Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto MT, Olson M, Koong AC, Koumenis C. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res 68(22):9323-30, 2008. e-Pub 2008. PMID: 19010906.
- King CR, Spiotto MT. Improved outcomes with higher doses for salvage radiotherapy after prostatectomy. Int J Radiat Oncol Biol Phys 71(1):23-7, 2008. e-Pub 2008. PMID: 18207668.
- King CR, Presti JC, Brooks JD, Gill H, Spiotto MT. Postoperative prostate-specific antigen velocity independently predicts for failure of salvage radiotherapy after prostatectomy. Int J Radiat Oncol Biol Phys 70(5):1472-7, 2008. e-Pub 2008. PMID: 17935902.
- Spiotto MT, Hancock SL, King CR. Radiotherapy after prostatectomy: improved biochemical relapse-free survival with whole pelvic compared with prostate bed only for high-risk patients. Int J Radiat Oncol Biol Phys 69(1):54-61, 2007. e-Pub 2007. PMID: 17459606.
- Zhang B, Bowerman NA, Salama JK, Schmidt H, Spiotto MT, Schietinger A, Yu P, Fu YX, Weichselbaum RR, Rowley DA, Kranz DM, Schreiber H. Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med 204(1):49-55, 2007. e-Pub 2007. PMID: 17210731.
- Spiotto MT, Schreiber H. Floxed reporter genes: Flow-cytometric selection of clonable cells expressing high levels of a target gene after tamoxifen-regulated Cre-loxP recombination. J Immunol Methods 312(1-2):201-8, 2006. e-Pub 2006. PMID: 16674971.
- Spiotto MT, Schreiber H. Rapid destruction of the tumor microenvironment by CTLs recognizing cancer-specific antigens cross-presented by stromal cells. Cancer Immun 5:8, 2005. e-Pub 2005. PMID: 15934727.
- Spiotto MT, Rowley DA, Schreiber H. Bystander elimination of antigen loss variants in established tumors. Nat Med 10(3):294-8, 2004. e-Pub 2004. PMID: 14981514.
- Spiotto MT, Reth MA, Schreiber H. Genetic changes occurring in established tumors rapidly stimulate new antibody responses. Proc Natl Acad Sci U S A 100(9):5425-30, 2003. e-Pub 2003. PMID: 12702750.
- Yu P, Spiotto MT, Lee Y, Schreiber H, Fu YX. Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells. J Exp Med 197(8):985-95, 2003. e-Pub 2003. PMID: 12695490.
- Spiotto MT, Yu P, Rowley DA, Nishimura MI, Meredith SC, Gajewski TF, Fu YX, Schreiber H. Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity 17(6):737-47, 2002. e-Pub 2002. PMID: 12479820.
Other Articles
- Phan, J, Spiotto, MT, Goodman, CD, Reddy, JP, Newcomm, P, Garden, AS, Lee, A Reirradiation for Locally Recurrent Head and Neck Cancer. Seminars in radiation oncology 35(2):243-258, 2025. PMID: 40090750.
- Rooney MK, Andring LM, Corrigan KL, Bernard V, Williamson TD, Fuller CD, Garden AS, Gunn B, Lee A, Moreno AC, Morrison WH, Phan J, Rosenthal DI, Spiotto M, Frank SJ Hypothyroidism following Radiotherapy for Head and Neck Cancer: A Systematic Review of the Literature and Opportunities to Improve the Therapeutic Ratio. Cancers (Basel) 15(17), 2023. PMID: 37686597.
- Dabaja, BS, Spiotto, MT Radiation for hematologic malignancies. Frontiers in Oncology 13, 2023. PMID: 37384297.
- Ni, K, Xu, Z, Culbert, A, Luo, T, Guo, N, Yang, K, Pearson, E, Preusser, B, Wu, T, La Rivière, PJ, Weichselbaum, RR, Spiotto, MT, Lin, W Author Correction. Nature Biomedical Engineering 6(12):1449-1450, 2022. PMID: 36369378.
- Rangel R, Pickering CR, Sikora AG, Spiotto MT Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy. Frontiers in immunology 13:840923, 2022. PMID: 35154165.
- Spiotto MT, Taniguchi CM, Klopp AH, Colbert LE, Lin SH, Wang L, Frederick MJ, Osman AA, Pickering CR, Frank SJ Biology of the Radio- and Chemo-Responsiveness in HPV Malignancies. Semin Radiat Oncol 31(4):274-285, 2021. PMID: 34455983.
- Taku, N, Wang, L, Garden, AS, Rosenthal, D, Gunn, GB, Morrison, WH, Fuller, C, Phan, J, Reddy, JP, Moreno, AC, Spiotto, MT, Chronowski, G, Shah, SJ, Mayo, LL, Gross, N, Ferrarotto, R, Zhu, XR, Zhang, X, Frank, SJ Proton Therapy for HPV-Associated Oropharyngeal Cancers of the Head and Neck. Current treatment options in oncology 22(6), 2021. PMID: 34086150.
- Das, T, Zhong, R, Spiotto, MT Erratum. Advances in experimental medicine and biology 1287:C1, 2021. PMID: 33284431.
- Spiotto MT, Connell PP Strategies to Overcome Late Complications from Radiotherapy for Childhood Head and Neck Cancers. Oral Maxillofac Surg Clin North Am 28(1):115-26, 2016. PMID: 26614704.
- Spiotto MT, Pytynia M, Liu GF, Ranck MC, Widau R Animal models to study the mutational landscape for oral cavity and oropharyngeal cancers. J Oral Maxillofac Res 4(1):e1, 2013. PMID: 24422024.
- Spiotto MT, Fu YX, Schreiber H Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation. Curr Opin Immunol 15(6):725-30, 2003. PMID: 14630209.
Book Chapters
- Das, T, Zhong, R, Spiotto, MT. Notch signaling and human papillomavirus–associated oral tumorigenesis, 105-122, 2021.
Selected Presentations & Talks
Local Presentations
- 2015. Preclinical Strategies to Target Human Papilloma Virus-positive Tumors. Conference. MD Anderson Cancer Center. Houston, TX, US.
Regional Presentations
- 2017. Lymph Node Metastasis in Head and Neck Cancer. Conference. University of Chicago. Chicago, IL, US.
- 2013. Clinical and Preclinical Studies in HPV-associated Head and Neck Cancer. Conference. Chicago Radiological Society. Chicago, IL, US.
- 2013. Post-operative Radiotherapy for Head and Neck Cancers. Conference. University of Chicago. Chicago, IL, US.
- 2013. Mouth Models of Oral Cancer. Conference. University of Chicago, US.
- 2012. Mouth Models of Oral Cancer. Conference. University of Chicago, US.
- 2012. Postoperative Head and Neck Radiation Therapy. Conference. University of Illinois-Chicago. Chicago, IL, US.
- 2011. Radiation Therapy for Cutaneous Malignancies. Conference. University of Illinois-Chicago. Chicago, IL, US.
National Presentations
- 2020. Spatial evolution of lymph node metastasis in Human Papillomavirus-negative Head and Neck Cancers. Conference. Multidisciplinary Head and Neck Cancers Symposium. Scottsdale, AZ, US.
- 2019. 2019 Grant Writing Workshop. Invited. 2019 ASTRO Annual meeting. Chicago, IL, US.
- 2019. Molecular Profiling of Lymph Node Metastasis in Head and Neck Cancer. Invited. New Horizons in Immunotherapy for Head and Neck Cancer. Newberg, OR, US.
- 2019. Molecular Classification of Lymph Node Metastases in Head and Neck Cancers. Invited. NRG Immunotherapy Science session. Phoenix, AZ, US.
- 2018. Molecular Classification of Lymph Node Metastases in HPV-Negative Head and Neck Cancers Identify Distinct Phenotypes That Predict for Survival. Conference. American Society of Therapeutic Radiation Oncology Annual Meeting. San Antonio, TX, US.
- 2018. Targeting the Tumor Microenvironment in Radiation Oncology Workshop. Invited. ASTRO.AACR. Washington, DC, US.
- 2015. Aurora Kinase inhibition sensitizes primary oral tumors to sub-therapeutic doses after image-guided radiotherapy. Conference. American Society of Therapeutic Radiation Oncology Annual Meeting. San Antonio, TX, US.
- 2015. Insertional mutagenesis in HPV cancers identifies that diametric changes in Notch1 activity promotes tumorigenesis. Conference. American Society of Therapeutic Radiation Oncology Annual Meeting. San Antonio, TX, US.
- 2012. A Novel Cell Based Assay for High Throughput Screening of Protein: Protein Interactions. Conference. Small Molecules Testing for Fanconi Anemia. Portland, OR, US.
- 2012. A High Throughput Cell Based Screen Identifies Compounds that Inhibit the Viral Oncoprotein E6 in Human Papillomavirus-positive Cancers. Conference. .” American Society of Therapeutic Radiation Oncology Annual Meeting. Boston, MA, US.
- 2012. A High Throughput Cell-Based Screen Identifies Compounds That Inhibit the Human Papillomavirus Oncoprotein E6 Without Damaging DNA. Conference. Fanconi Anemia Research Fund Annual Meeting. Denver, CO, US.
International Presentations
- 2023. Rescue of Radiation Induced Lymphocyte Depletion by Flash Radiotherapy. Invited. 2023 Flash Radiotherapy & Particle Therapy. Toronto, CA.
Grant & Contract Support
| Date: | 2023 - 2028 |
| Title: | Combining Effective Radiotherapeutic-strategies to enhance Vaccinations against Cervical cancer (CERVICAL) ROBIN: Administrative Core |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | U54CA281787 |
| Date: | 2023 - 2028 |
| Title: | Combining Effective Radiotherapeutic-strategies to enhance Vaccinations against Cervical cancer (CERVICAL) ROBIN Project 2: Molecular and immune drivers of HPV-specific responses following radiotherapy for cervical cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | U54CA281787 |
| Date: | 2023 - 2026 |
| Title: | Enhancing Immune Responses in Pancreatic Cancer by Stromal Inhibition of HIF2 |
| Funding Source: | CPRIT |
| Role: | PI |
| ID: | RP230224 |
| Date: | 2023 - 2026 |
| Title: | Focal radiotherapy in stimulate immune responses against systemic leukemias |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP230278 |
| Date: | 2020 - 2023 |
| Title: | Funds to be used to help purchase state-of-the-art research equipment and make necessary laboratory renovations to encourage faculty members to perform their research at U. T. institutions |
| Funding Source: | UT Rising STARS Funding |
| Role: | PI |
| Date: | 2018 - 2023 |
| Title: | DRP-Dabaja FP12602: Exploring the Potential immune Priming Role of Radiation in Extramedullary Acute Myelogenous Leukemia (AML): Can Radiation Increase the Efficacy of Checkpoint Inhibitors |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | 5P50CA100632-20 |
| Date: | 2018 - 2020 |
| Title: | Combining Nanotechnology and Radiation to Enhance Checkpoint Blockade Immunotherapy of Advanced Prostate Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-PI |
| ID: | PC170934P2 |
| Date: | 2018 - 2023 |
| Title: | Viral Replication Pathways During Oral Tumorigenesis and Response to Therapy |
| Funding Source: | NIH/NIDCR |
| Role: | PI |
| ID: | 5R01DE027445-06 |
| Date: | 2012 - 2018 |
| Title: | Identification of chromosomal aberrations that cooperate with the human papillomavirus to cause cancer |
| Funding Source: | Burroughs Wellcome Fund Career Award for Medical Scientists |
| Role: | PI |
| Date: | 2012 - 2015 |
| Title: | Non-Genotoxic Inhibitors for Human Papillomavirus-Induced Head and Neck Cancers in Fanconi Anemia |
| Funding Source: | Fanconi Anemia Research Foundation |
| Role: | PI |
Patient Reviews
CV information above last modified May 27, 2025