Min Gyu Lee, Ph.D.
Department of Molecular and Cellular Oncology, Division of Discovery Science
About Dr. Min Gyu Lee
Histone lysine methylation is a hallmark of epigenetic and transcriptional regulation of gene expression. This modification is associated with either gene activation or repression and is modulated by histone methylation modifiers, such as histone methyltransferases (methyl writers) and demethylases (methyl erasers). My laboratory has studied the roles of histone methylation modifiers and their cofactor proteins in regulating cancer-epigenetic events and cellular differentiation. My earlier work led to not only the discovery of essential factors for the histone demethylase LSD1 (also called KDM1A and BHC110) but also the identification of small molecule inhibitors and novel histone demethylases as follows: (i) The first identified histone demethylase LSD1, which removes methyl groups from dimethyl histone H3 lysine 4 (H3K4me2) and also from H3K9me2 in certain circumstance, is regulated by its cofactor proteins, such as CoREST and histone deacetylases 1/2 (Nature 2005; Mol. Cell. Biol. 2006); (ii) Tranylcypromine is an LSD1 inhibitor (Chem. Biol. 2006); and (iii) We identified and characterized two novel families of histone demethylases represented by JARID1D (also called KDM5D) and UTX (alias KDM6A), which reverse tri- and dimethyl H3K4 and tri- and dimethyl H3K27, respectively (Cell 2007; Science 2007).
We have expanded our research to define the biological roles of histone methylation modifiers and their cofactor proteins (e.g., the H3K27 demethylase UTX, the UTX-interacting H3K4 methyltransferase MLL4, the MLL4-antagonizing factor PRMT7, the H3K4 demethylase JARID1D, and the H3K36 demethylase KDM2A). Thus, we have characterized the unanticipated functions for histone methylation modifiers and their associated factors in regulating cancer and cellular differentiation (e.g., Genes Dev. 2012; J. Clin. Invest. 2013; J. Biol. Chem. 2014; Cancer Res. 2014 & 2016; Nucleic Acids Res. 2016a & 2016b; Molecular Cell 2016 & 2018; J. Biol. Chem. 2018; Cancer Res. 2018; Nature Commun. 2019; Cancer Cell 2020; Nature Commun. 2022; Cell Reports 2025; Science Advances 2025). These previous studies with far-reaching impacts, along with our epigenetic expertise, put my laboratory in an ideal position to understand the epigenetic mechanism for tumorigenesis.
Present Title & Affiliation
Primary Appointment
Professor, Molecular Oncology, Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX
Regular member, Cancer Biology Program, Graduate School of Biomedical Sciences (GSBS), The MD Anderson UTHealth Houston Graduate School, Houston, Texas
Faculty, Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2003 | Johns Hopkins University, School of Medicine, Baltimore, Maryland, US, Biological Chemistry, Dr. Peter L Pedersen, Ph.D |
| 1993 | Seoul National University, Seoul, Agricultural Chemistry, M.S |
| 1991 | Seoul National University, Seoul, Agricultural Chemistry, BS |
Postgraduate Training
| 2004-2007 | Research Fellowship, The Wistar Institute, Philadelphia, Pennsylvania |
| 2003-2004 | Research Fellowship, Johns Hopkins University, Baltimore, Maryland |
Experience & Service
Faculty Academic Appointments
Associate Professor, Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2021
Assistant Professor, Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - 2015
Staff Scientist, The Wistar Institute, Philadelphia, PA, 2007 - 2008
Other Professional Positions
Researcher, Hyundai Pharmaceutical Industrial Co., Ltd, Bucheon, 1993 - 1998
Intramural Institutional Committee Activities
Member, GSBS Cancer Biology Program Steering committee, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Faculty Senate, The University of Texas MD Anderson Cancer Center, 2023 - 2025
Member, GSBS Cancer Biology Program Membership Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Advisory Committee for Chair Search of Department of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer Center, 2023 - 2024
Ad Hoc Member,, Committee for Institutional “Bioscience Research Facility”, The University of Texas MD Anderson Cancer Center, 2023
Member, The Faculty Academic Review Committee (FARC) in UT MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, GSBS Membership Committee, The University of Texas MD Anderson Cancer Center, 2018 - 2020
Reviewer, GSBS Knudson Dissertation Award, The University of Texas MD Anderson Cancer Center, 2018
Member, Review Committee for GSBS Kopchick Research Award, The University of Texas MD Anderson Cancer Center, 2018
Ad Hoc Member, INTEREST Grant Review Committee, The University of Texas MD Anderson Cancer Center, 2016
Member, Program Income Advisory Committee for Institutional Research Animal in MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2015 - 2024
Sub-Committee Chair, "Research Conduct" Seminar Series, T32 Training Grant in Cancer Biology Program (TGCBP), The University of Texas MD Anderson Cancer Center, 2015 - 2018
Member, Odyssey Fellowship, The University of Texas MD Anderson Cancer Center, 2014 - 2017
Member, Institutional Animal Care and Use Committee (IACUC), The University of Texas MD Anderson Cancer Center, 2014 - 2017
Member, The Faculty Academic Review Committee (FARC) in UT MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2014 - 2017
Chair, Annual Capital Equipment Purchase in the Department of Molecular and Oncology, The University of Texas MD Anderson Cancer Center, 2013 - 2017
Reviewer, Schissler Foundation Fellowship Reviewer, GSBS, The University of Texas MD Anderson Cancer Center, 2013
Reviewer, Sowell Huggins Scholarship Reviewer, GSBS, The University of Texas MD Anderson Cancer Center, 2011
Subcommittee Member, UT GSBS Graduate Student Admissions for Cancer Biology Program, The University of Texas MD Anderson Cancer Center, 2010 - 2011
Honors & Awards
| 2011 | Cancer Center Support Grant Faculty Development Award |
| 2008 | Christopher Davis Fellowship Memorial Award |
| 1988 - 1991 | University Honor Student, Seoul National University, South Korea |
| 1987 - 1991 | Cheonbuk-aehyang Foundation Scholarship |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2022. Epigenetic Oncogenesis Mechanisms. Visiting. Epigenetic Oncogenesis Mechanisms. Houston, TX, US.
- 2021. Epigenetic Mechanisms of Tumor Suppression. Invited. Epigenetic Mechanisms of Tumor Suppression. Waco, TX, US.
- 2019. Epigenetic Modifiers in Cancer and Metastasis. Invited. Epigenetic Modifiers in Cancer and Metastasis. Houston, TX, US.
- 2015. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Invited. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Houston, US.
- 2013. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Visiting. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Houston, TX, US.
- 2013. Roles of Histone Methylation Modifiers in Cancer and Cellular Differentiation. Visiting. Roles of Histone Methylation Modifiers in Cancer and Cellular Differentiation. Houston, TX, US.
- 2013. Diverse Roles of Histone Methylation Modifiers in Cancer and Differentiation. Visiting. Diverse Roles of Histone Methylation Modifiers in Cancer and Differentiation. Houston, TX, US.
- 2010. Epigenetic Roles of Histone Lysine Demethylases. Invited. Epigenetic Roles of Histone Lysine Demethylases. Houston, TX, US.
- 2008. Histone Lysine Demethylation and Its Role in Chromatin Function. Visiting. Histone Lysine Demethylation and Its Role in Chromatin Function. Houston, TX, US.
Regional Presentations
- 2008. Histone Lysine Demethylation and Its Role in Chromatin Function. Invited. School of Medicine. Dallas, TX, US.
National Presentations
- 2025. Epigenetic Modifiers and Tumorigenesis. Houston, Texas, US.
- 2022. Epigenetic Aberrations and Oncogenesis Mechanisms. Invited. West Lafayette, IN, US.
- 2022. Altered Epigenetic Pathways for Tumorigenesis. Invited. Indianapolis, IN, US.
- 2021. Epigenetic Mechanisms for Tumorigenesis. Invited. Buffalo, NY, US.
- 2021. Epigenetic Alterations and Tumorigenesis Mechanisms. Invited. Ann Harbor, MI, US.
- 2019. Epigenetic Modulators, Cancer, and Metastasis. Invited. Philadelphia, PA, US.
- 2019. Epigenetic Regulators, Tumorigenesis and Metastasis. Invited. Minneapolis, MN, US.
- 2017. Histone Modifiers in Cancer and Metastasis. Invited. Bethesda, MD, US.
- 2015. Epigenetic Histone Methylation Modifiers in Cancer and Stem Cells. Invited. Miami, FL, US.
- 2008. Histone Lysine Demethylation and Its Role in Chromatin Function. Invited. Chapel Hill, NC, US.
- 2007. Histone Lysine Demethylation and Its Role in Chromatin Function. Invited. School of Medicine. Irvine, CA, US.
- 2006. Histone Demethylation and Its Role in Chromatin Function. Invited. Fox Chase Cancer Center. Philadelphia, PA, US.
- 2006. Histone Demethylation and Its Role in Gene Regulation. Invited. School of Medicine and Dentistry. Birmingham, AL, US.
International Presentations
- 2021. Tumor-Suppressive Function of the Epigenetic Modifier MLL4 (Virtual). Visiting, US.
- 2019. Epigenetic Regulators, Cancer, and Metastasis. Invited.
- 2019. Epigenetic Regulators, Tumorigenesis, and Metastasis. Invited.
- 2018. Epigenomic Modifiers, Cancer and Metastasis. Invited.
- 2014. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Invited.
- 2014. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Invited.
- 2014. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Invited.
- 2014. Epigenetic Roles of Histone Methylation Modifiers in Cancer and Differentiation. Invited.
- 2006. Histone Demethylation and Its Role in Gene Regulation. Invited.
Grant & Contract Support
| Date: | 2024 - 2026 |
| Title: | UTEP/UTMDACC Partnership for Hispanic Cancer Disparities Research |
| Funding Source: | CPRIT |
| Role: | Mentor |
| ID: | RP210153 |
| Date: | 2023 - 2028 |
| Title: | CRACD-controlled cell plasticity and small cell lung cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA278967-01A1 |
| Date: | 2022 - 2027 |
| Title: | Heterozygous KMT2D Loss and Medulloblastoma |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R01CA262324-01A1 |
Selected Publications
Peer-Reviewed Articles
- Dhar SS, Ko KP, Jang J, Brown-Abel C, Lin T, Awasthi S, Chen K, Sillitoe RV, Park JI, Lee MG. KMT2D temporally activates neuronal transcriptional factor genes to mediate cerebellar granule cell differentiation. Science Advances 11(39):eadu7174, 2025. e-Pub 2025. PMID: 41004595.
- Song, S, Fan, Y, Zou, G, Huo, L, Kumar, J, Li, Y, Wang, R, Dai, E, Jin, J, Scott, AW, Shao, SH, Pizzi, M, Vykoukal, JV, Katayama, H, Hanash, S, Calin, GA, Zhang, X, Lee, MG, Wang, Z, Lo, Y, Gan, Q, Waters, R, Yin, F, Wang, L, Cheng, X, Ajani, JA, Dhar, SS. KAP1 promotes gastric adenocarcinoma progression by activating Hippo/YAP1 signaling via binding to HNRNPAB. Cancer Letters 621, 2025. e-Pub 2025. PMID: 40189014.
- Dhar, SS, Brown, CA, Rizvi, A, Reed, L, Kotla, S, Zod, C, Abraham, J, Abe, J, Rajaram, V, Chen, K, Lee, MG. Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS. Cell Reports 44(5), 2025. e-Pub 2025. PMID: 40286267.
- Cai, L, Wu, F, Zhou, Q, Gao, Y, Yao, B, Deberardinis, RJ, Acquaah-Mensah, G, Aidinis, V, Beane, J, Biswal, S, Chen, T, Concepcion-Crisol, CP, Grüner, BM, Jia, D, Jones, RA, Kurie, JM, Lee, MG, Lindahl, P, Lissanu, Y, Lorz, C, MacPherson, D, Martinelli, R, Mazur, PK, Mazzilli, SA, Mii, S, Moll, HP, Moorehead, RA, Morrisey, EE, Ng, SR, Oser, M, Pandiri, AR, Powell, CA, Ramadori, G, Santos, M, Snyder, EL, Sotillo, R, Su, KY, Taki, T, Taparra, K, Tran, PT, Xia, Y, Van Veen, JE, Winslow, MM, Xiao, G, Rudin, CM, Oliver, TG, Xie, Y, Minna, J. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models. Cancer Research 85(10):1769-1783, 2025. e-Pub 2025. PMID: 40298430.
- George J, Chen Y, Abdelfattah N, Yamamoto K, Gallup TD, Adamson SI, Rybinski B, Srivastava A, Kumar P, Lee MG, Baskin DS, Jiang W, Choi JM, Flavahan W, Chuang JH, Kim BY, Xu J, Jung SY, Yun K. Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors. Cancer Res Commun 2(6):402-416, 2022. e-Pub 2022. PMID: 36688010.
- M‡ N, S‡ W, Gore B, Abbas H, Lee K, Checker R, Dhar SS, Rajapakshe K, Tan AC, Lee MG*, Coarfa C*, Flores ER*. ΔNp63 executes an oncogenic program through the regulation of common landscape of enhancer associated genes in non-small cell lung cancer. Nature Communications (*Co-Corresponding author) 13(1):614, 2022. e-Pub 2022. PMID: 35105868.
- Wang G, Xia B, Zhou M, Lv J, Zhao D, Li Y, Bu Y, Wang X, Cooke JP, Cao Q, Lee MG, Zhang L, Chen K. MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes. Genomics Proteomics Bioinformatics 19(1):140-153, 2021. e-Pub 2021. PMID: 33677108.
- Zhao D, Zhang L, Zhang M, Xia B, Lv J, Gao X, Wang G, Meng Q, Yi Y, Zhu S, Tomoiaga AS, Lee MG, Cooke JP, Cao Q, Chen K. Broad genic repression domains signify enhanced silencing of oncogenes. Nat Communications 11(1):5560, 2020. e-Pub 2020. PMID: 33144558.
- Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Reports 33(3):108293, 2020. e-Pub 2020. PMID: 33086062.
- Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer 146(10):2822-2828, 2020. e-Pub 2020. PMID: 31472018.
- Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen TY, Lin YH, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG. KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. Cancer Cell 37(4):599-617, 2020. e-Pub 2020. PMID: 32243837.
- Wang G, Long J, Gao Y, Zhang W, Han F, Xu C, Sun L, Yang SC, Lan J, Hou Z, Cai Z, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK. SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nature Cell Biology 21(2):214-225, 2019. e-Pub 2019. PMID: 30692626.
- Park MK, Yao Y, Xia W, Setijono SR, Kim JH, Vila IK, Chiu HH, Wu Y, Billalabeitia EG, Lee MG, Kalb RG, Hung MC, Pandolfi PP, Song SJ, Song MS. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nature Communications 10(1):636, 2019. e-Pub 2019. PMID: 30733438.
- Liu Y, Qin S, Chen TY, Lei M, Dhar SS, Ho JC, Dong A, Loppnau P, Li Y, MG* L, J* M. Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Nature Communications (*Co-Corresponding author) 10(1):36, 2019. e-Pub 2019. PMID: 30604749.
- Alam H, Li N, Dhar SS, Wu SJ, Lv J, Chen K, Flores ER, Baseler L, Lee MG. HP1γ promotes lung adenocarcinoma by downregulating the transcription-repressive regulators NCOR2 and ZBTB7A. Cancer Research 78(14):3834-3848, 2018. e-Pub 2018. PMID: 29764865.
- Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Molecular Cell 70(5):825-841.e6, 2018. e-Pub 2018. PMID: 29861161.
- Chen TY, Lee SH, Dhar SS, Lee MG. Protein arginine methyltransferase 7-mediated microRNA-221 repression maintains Oct4, Nanog, and Sox2 levels in mouse embryonic stem cells. J Biol Chem 293(11):3925-3936, 2018. e-Pub 2018. PMID: 29378844.
- Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget 8(39):65548-65565, 2017. e-Pub 2017. PMID: 29029452.
- Lee SH, Chen TY, Dhar SS, Gu B, Chen K, Kim YZ, Li W, Lee MG. A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness. Nucleic Acids Research 44(22):10603-10618, 2016. e-Pub 2016. PMID: 27625395.
- Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Molecular Cell 63(3):470-84, 2016. e-Pub 2016. PMID: 27477906.
- Dhar SS, Lee SH, Chen K, Zhu G, Oh W, Allton K, Gafni O, Kim YZ, Tomoiga AS, Barton MC, Hanna JH, Wang Z, Li W, Lee MG. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Research 8(8):3659-74, 2016. e-Pub 2016. PMID: 26762983.
- Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG. JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis. Cancer Research 76(4):831-43, 2016. e-Pub 2016. PMID: 26747897.
- Kim J, Sharma A, Dhar SS, Lee S, Gu B, Chan CH, Lin HK, Lee MG. UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells. Cancer Research 74(6):1705-17, 2014. e-Pub 2014. PMID: 24491801.
- Dhar SS, Alam H, Li N, Wagner KW, Chung J, Ahn YW, Lee MG. Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells. J Biol Chem 289:7483-7496, 2014. e-Pub 2014. PMID: 24482232.
- Wagner K, Alam H, Dhar S, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani A, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung M, Heymach J, Lee MG. KDM2A Promotes Lung Tumorigenesis by Epigenetically Enhancing ERK1/2 Signaling. J Clin Invest 123:5231-5246, 2013. e-Pub 2013. PMID: 24200691.
- Dhar SS, Lee SH, Kan PY, Voigt P, Ma L, Shi X, Reinberg D, Lee MG. Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev 26(24):2749-62, 2012. e-Pub 2012. PMID: 23249737.
- Wen H, Li J, Song T, Lu M, Kan PY, Lee MG, Sha B, Shi X. Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem 285(13):9322-6, 2010. e-Pub 2010. PMID: 20129925.
- Smith ER, Lee MG, Winter B, Droz NM, Eissenberg JC, Shiekhattar R, Shilatifard A. Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol 28(3):1041-6, 2008. e-Pub 2008. PMID: 18039863.
- Ingvarsdottir K, Edwards C, Lee MG, Lee JS, Schultz DC, Shilatifard A, Shiekhattar R, Berger SL. Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol 27(22):7856-64, 2007. e-Pub 2007. PMID: 17875926.
- Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R. Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination. Science 318(5849):447-50, 2007. e-Pub 2007. PMID: 17761849.
- Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. p53 is regulated by the lysine demethylase LSD1. Nature 449(7158):105-8, 2007. e-Pub 2007. PMID: 17805299.
- Eissenberg JC, Lee MG, Schneider J, Ilvarsonn A, Shiekhattar R, Shilatifard A. The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nature Structural & Molecular Biology 14(4):344-6, 2007. e-Pub 2007. PMID: 17351630.
- Lee MG, Norman J, Shilatifard A, Shiekhattar R. Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell 128(5):877-887, 2007. e-Pub 2007. PMID: 17320162.
- Nicolas E, Lee MG, Hakimi MA, Cam HP, Grewal SI, Shiekhattar R. Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions. J Biol Chem 281(47):35983-8, 2006. e-Pub 2006. PMID: 16990277.
- Lee MG, Wynder C, Schmidt DM, McCafferty DG, Shiekhattar R. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol 13(6):563-7, 2006. e-Pub 2006. PMID: 16793513.
- Lee MG, Wynder C, Bochar DA, Hakimi MA, Cooch N, Shiekhattar R. Functional interplay between histone demethylase and deacetylase enzymes. Mol Cell Biol 26(17):6395-6402, 2006. e-Pub 2006. PMID: 16914725.
- Lee MG, Wynder C, Norman J, Shiekhattar R. Isolation and characterization of histone H3 lysine 4 demethylase-containing complexes. Methods 40(4):327-30, 2006. e-Pub 2006. PMID: 17101444.
- Lee MG, Wynder C, Cooch N, Shiekhattar R. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437(7057):432-5, 2005. e-Pub 2005. PMID: 16079794.
- Lee MG, Pedersen PL. Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region of the type II hexokinase promoter. J Biol Chem 278(42):41047-58, 2003. e-Pub 2003. PMID: 12893819.
Invited Articles
- Dhar SS, Lee MG. Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors. Oncotarget 12(13):1296-1308, 2021. e-Pub 2021. PMID: 34194626.
- Gu B, Lee MG. Histone H3 Lysine 4 Methyltransferases and Demethylases in Self-renewal and Differentiation of Stem Cells. Cell & Bioscience 3(1):39, 2013. e-Pub 2013. PMID: 24172249.
Review Articles
- Alam H, Gu B, Lee MG. Histone methylation modifiers in cellular signaling pathways. Cell Mol Life Sci 72(23):4577-92, 2015. e-Pub 2015. PMID: 26305020.
Patient Reviews
CV information above last modified July 22, 2026