Na Niu, MD,PHD

Peer-Reviewed Articles

1. Ottum S, De Tommasi O, Demirkiran C, Bellone S, Buza N, Niu N, Sethi N, Hartwich TM, Santin AD. Activity of datopotamab deruxtecan in TROP2-expressing low-grade serous ovarian cancer: a preclinical study. Gynecol Oncol Rep 66:102146, 2026. e-Pub 2026. PMID: 42368461.
2. Niu N, Buza N, Hui P. Genetic Stability of Short Tandem Repeat (STR) Loci in Human Term Placentas. Int J Gynecol Pathol, 2026. e-Pub 2026. PMID: 42348451.
3. Sun T, Niu N, Healy C, Abdelal H, Wang M, Hui P, Buza N. Fumarate Hydratase-deficient Uterine Smooth Muscle Tumors: A 6-Year Prospective Analysis of Morphology-based Screening and Patient Outcomes. Int J Gynecol Pathol 45(3):189-199, 2026. e-Pub 2026. PMID: 40991420.
4. Ettorre VM, Conca B, Demirkiran C, Bellone S, Sethi N, Hartwich TMP, Niu N, Buza N, Angioli R, Plotti F, Palmieri L, Santin AD. Folate receptor alpha as a successful biomarker in the treatment of low-grade serous ovarian cancer patients using preclinical and clinical models. Int J Gynecol Cancer 36(2):102779, 2026. e-Pub 2026. PMID: 41411700.
5. Amraei R, Niu N, Clark M, Ratner E, Buza N, Hui P. STR genotyping diagnosis of hydatidiform moles: an assessment of 2871 consecutive products of conceptions. Virchows Arch 487(5):1025-1034, 2025. e-Pub 2025. PMID: 41076484.
6. Ettorre VM, Demirkiran C, Bellone S, Niu N, Buza N, Sethi N, Hartwich TMP, Palmieri L, Santin AD. Preclinical activity of sacituzumab govitecan in TROP2-positive low-grade serous ovarian cancer patient-derived xenograft models. Int J Gynecol Cancer 35(9):101988, 2025. e-Pub 2025. PMID: 40680453.
7. Zhang T, Niu N, Taddei T, Jain D, Zhang X. Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes. Am J Clin Pathol 163(3):411-418, 2025. e-Pub 2025. PMID: 39418121.
8. Niu N, Buza N, Hui P. Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations. Int J Gynecol Pathol 44(1):42-48, 2025. e-Pub 2025. PMID: 38959396.
9. Nagy A, Niu N, Sun T, Buza N, Hui P. Diandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction?. Histopathology 85(6):879-888, 2024. e-Pub 2024. PMID: 39031756.
10. Nagy A, Niu N, Ratner E, Hui P, Buza N. Novel FOXL2 Mutation in an Ovarian Adult Granulosa Cell Tumor: Report of a Case With Diagnostic and Clinicopathologic Implications. Int J Gynecol Pathol 43(6):631-636, 2024. e-Pub 2024. PMID: 38426544.
11. Niu N, Roy SF, Ko CJ. A pilot study of p53 immunohistochemistry in atypical squamous lesions, using a vulvar scoring system. J Cutan Pathol 51(5):379-386, 2024. e-Pub 2024. PMID: 38317537.
12. Zou G, Huang Y, Zhang S, Ko KP, Kim B, Zhang J, Venkatesan V, Pizzi MP, Fan Y, Jun S, Niu N, Wang H, Song S, Ajani JA, Park JI. E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming. J Exp Med 221(4), 2024. e-Pub 2024. PMID: 38411616.
13. Niu N, Ordulu Z, Burak Z, Buza N, Hui P. Extrauterine epithelioid trophoblastic tumour and its somatic carcinoma mimics: short tandem repeat genotyping meets the diagnostic challenges. Histopathology 84(2):325-335, 2024. e-Pub 2024. PMID: 37743102.
14. Niu N, Heberton MM, Tang Z, Aung PP, Nagarajan P, Curry JL, Prieto VG, Torres-Cabala CA, Cho WC. Lymphomatoid papulosis with DUSP22-IRF4 rearrangement: A case report and literature review. J Cutan Pathol 50(8):711-716, 2023. e-Pub 2023. PMID: 36944579.
15. Zhang, X, Yao, J, Li, X, Niu, N, Liu, Y, Hajek, RA, Peng, G, Westin, SN, Sood, AK, Liu, J. Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer. Science Advances 9(29), 2023. e-Pub 2023. PMID: 37478190.
16. Zhang, X, Yao, J, Niu, N, Li, X, Liu, Y, Huo, L, Euscher, ED, Wang, H, Bell, D, Sood, AK, Wang, G, Lawson, BC, Ramalingam, P, Malpica, A, Sahin, AA, Ding, Q, Liu, J. SOX17:A Highly Sensitive and Specific Immunomarker for Ovarian and Endometrial Carcinomas. Modern Pathology 36(2), 2023. e-Pub 2023. PMID: 36853778.
17. Niu N, Yao J, Bast RC, Sood AK, Liu J. IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming. Oncogenesis 10(9):65, 2021. e-Pub 2021. PMID: 34588424.
18. Niu N, Shen W, Zhong Y, Bast RC Jr, Jazaeri A, Sood AK, Liu J. Expression of B7-H4 and IDO1 is associated with drug resistance and poor prognosis in high-grade serous ovarian carcinomas. Hum Pathol 113:20-27, 2021. e-Pub 2021. PMID: 33887301.
19. Shen W, Niu N, Lawson B, Qi L, Zhang J, Li T, Zhang H, Liu J. GATA6: a new predictor for prognosis in ovarian cancer. Hum Pathol 86:163-169, 2019. e-Pub 2019. PMID: 30633927.
20. Chen J, Niu N, Zhang J, Qi L, Shen W, Donkena KV, Feng Z, Liu J. Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer. Curr Cancer Drug Targets 19(5):360-367, 2019. e-Pub 2019. PMID: 29968537.
21. Niu N, Mercado-Uribe I, Liu J. Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells. Oncogene 36(34):4887-4900, 2017. e-Pub 2017. PMID: 28436947.
22. Niu N, Zhang J, Zhang N, Mercado-Uribe I, Tao F, Han Z, Pathak S, Multani AS, Kuang J, Yao J, Bast RC, Sood AK, Hung MC, Liu J. Linking genomic reorganization to tumor initiation via the giant cell cycle. Oncogenesis 5(12):e281, 2016. e-Pub 2016. PMID: 27991913.
23. Liang L, Jiang Y, Chen JS, Niu N, Piao J, Ning J, Zu Y, Zhang J, Liu J. B7-H4 expression in ovarian serous carcinoma: a study of 306 cases. Hum Pathol 57:1-6, 2016. e-Pub 2016. PMID: 27349304.
24. Liang L, Olar A, Niu N, Jiang Y, Cheng W, Bian XW, Yang W, Zhang J, Yemelyanova A, Malpica A, Zhang Z, Fuller GN, Liu J. Primary Glial and Neuronal Tumors of the Ovary or Peritoneum: A Clinicopathologic Study of 11 Cases. Am J Surg Pathol 40(6):847-56, 2016. e-Pub 2016. PMID: 26990854.
25. Wei X, Zhang D, Dou X, Niu N, Huang W, Bai J, Zhang G. Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. BMC Cancer 14:841, 2014. e-Pub 2014. PMID: 25406731.
26. Zhang J, Niu N, Li B, McNutt MA. Neuron-derived IgG protects neurons from complement-dependent cytotoxicity. J Histochem Cytochem 61(12):869-79, 2013. e-Pub 2013. PMID: 23979841.
27. Niu N, Zhang J, McNutt MA. Endogenous IgG affects the cell biology of RPE cells and involves the TLR4 pathway. Invest Ophthalmol Vis Sci 54(10):7045-52, 2013. e-Pub 2013. PMID: 24106112.
28. Zhang J, Niu N, Wang M, McNutt MA, Zhang D, Zhang B, Lu S, Liu Y, Liu Z. Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the FcgammaR I and TLR4 pathways. Int J Biochem Cell Biol 45(8):1911-20, 2013. e-Pub 2013. PMID: 23791745.
29. Niu N, Qin X. New insights into IL-7 signaling pathways during early and late T cell development. Cell Mol Immunol 10(3):187-9, 2013. e-Pub 2013. PMID: 23584490.
30. Lu S, Niu N, Guo H, Tang J, Guo W, Liu Z, Shi L, Sun T, Zhou F, Li H, Zhang J, Zhang B. ARK5 promotes glioma cell invasion, and its elevated expression is correlated with poor clinical outcome. Eur J Cancer 49(3):752-63, 2013. e-Pub 2013. PMID: 23063350.
31. Zhang J, Zhang B, Zhang X, Sun Y, Wei X, McNutt MA, Lu S, Liu Y, Zhang D, Wang M, Lin Z, Niu N. SATB1 expression is associated with biologic behavior in colorectal carcinoma in vitro and in vivo. PLoS One 8(1):e47902, 2013. e-Pub 2013. PMID: 23326301.
32. Liu Y, Chen Z, Niu N, Chang Q, Deng R, Korteweg C, Gu J. IgG gene expression and its possible significance in prostate cancers. Prostate 72(6):690-701, 2012. e-Pub 2012. PMID: 22430367.
33. Niu N, Zhang J, Huang T, Sun Y, Chen Z, Yi W, Korteweg C, Wang J, Gu J. IgG expression in human colorectal cancer and its relationship to cancer cell behaviors. PLoS One 7(11):e47362, 2012. e-Pub 2012. PMID: 23133595.
34. Niu N, Zhang J, Sun Y, Wang S, Sun Y, Korteweg C, Gao W, Gu J. Expression and distribution of immunoglobulin G and its receptors in an immune privileged site: the eye. Cell Mol Life Sci 68(14):2481-92, 2011. e-Pub 2011. PMID: 21061041.
35. Niu N, Zhang J, Guo Y, Zhao Y, Korteweg C, Gu J. Expression and distribution of immunoglobulin G and its receptors in the human nervous system. Int J Biochem Cell Biol 43(4):556-63, 2011. e-Pub 2011. PMID: 21167303.
36. Zhou Y, Pan P, Yao L, Su M, He P, Niu N, McNutt MA, Gu J. CD117-positive cells of the heart: progenitor cells or mast cells?. J Histochem Cytochem 58(4):309-16, 2010. e-Pub 2010. PMID: 20026668.
37. Niu N, Zhang J, Guo Y, Yang C, Gu J. Cystic fibrosis transmembrane conductance regulator expression in human spinal and sympathetic ganglia. Lab Invest 89(6):636-44, 2009. e-Pub 2009. PMID: 19333236.

Review Articles

1. Liu J, Niu N, Li X, Zhang X, Sood AK. The life cycle of polyploid giant cancer cells and dormancy in cancer: Opportunities for novel therapeutic interventions. Semin Cancer Biol 81:132-144, 2022. e-Pub 2022. PMID: 34670140.

Abstracts

1. Salehiazar, S, Niu, Na, Hui, P, Buza, N. Association of p53 and p16 Expression Patterns with Mutational Landscapes in a Large Cohort of Endometrial Serous Carcinomas. USCAP Annual Meeting.
2. Niu, Na, Imelda Mercado-Uribe, Jinsong Liu. Re-thinking the concept of cancer stem cells: Polyploid giant cancer cells as mother cancer stem cells. AACR Annual Meeting.
3. Liang, L, Jiang, Y, Niu, Na, Liu, JS. B7-H4 expression in ovarian serous carcinoma: A study of 306 tissue samples. USCAP Annual Meeting.
4. Liang, L, Niu, Na, Yemelyanova, A, Liu, JS. Primary glial and neuronal tumors of the ovary or peritoneum: A Clinicopathologic study of 11 cases. USCAP Annual Meeting.
5. Niu, Na, Zhang, J, Mercado-Uribe, I, Liu, JS. Single cell live imaging of resistant cancer cell generation via an amitotic giant cell cycle. AACR Annual Meeting.
6. Niu, Na, Mercado-Uribe, I, Liu, JS. Dedifferentiation into polyploid blastomere-like cancer stem cells via formation of polyploid giant cancer cells. AACR Annual Meeting.
7. Niu, Na, Sood, A, Liu, J. Polyploid giant cancer cells lead to the evolution of drug resistance in high-grade ovarian cancer. AACR Annual Meeting.
8. Niu, Na, Tang, Z, Torres-Cabala, C, Cho, W. Lymphomatoid Papulosis with DUSP22-IRF4 Rearrangement: A Case Report and Review of Literature. CAP annual meeting.
9. Niu, Na, Rothrock, A, Nelson, K, Wong, M, Prieto, V, Cho, W. Malignant Proliferating Trichilemmal Tumor Harboring TP53 and POLE mutations Arising in Association with Incontinentia Pigmenti. ASDP annual meeting.
10. Niu, Na, Buza, N, Hui, P, Sun, T. Morphological Features are neither Sensitive nor Specific for the Diagnosis of Fumarate Hydratase Deficient Leiomyoma: A Clinicopathologic Study of 99 Uterine Leiomyomas with Atypical Nuclei. USCAP annual meeting.
11. Niu, Na, Buza, N, Hui, P. STR Genotyping: A Precision Diagnostic Tool for Extrauterine Presentations of Epithelioid Trophoblastic Tumor and Its Somatic Carcinoma Mimics. USCAP meeting.
12. Amraei,R, Niu, Na, Buza, N, Hui, P. Clinical Performance of STR Genotyping Diagnosis of Hydatidiform Moles: An Assessment of 2871 Products of Conceptions. USCAP annual meeting.
13. Zhang, T, Niu, Na, Jain, D, Zhang, X. Steatohepatitic Hepatocellular Carcinoma: Insights into Background Liver Disease, Histological Characteristics, and Survival. USCAP annual meeting.
14. Kadam-Maruthi, V, Niu, Na, Hui, P, Buza, N. Frequent Discordant HER2 Status Between Primary and Metastatic Endometrial Serous Carcinomas in the Setting of Targeted Therapy. USCAP annual meeting.
15. Niu, Na, Buza, N, Hui, P, Sun, T. Comprehensive Genomic Profiling of Endometrioid Carcinoma with Squamous Differentiation. USCAP annual meeting.
16. Niu, Na, Nagy, A, Sun, T, Buza, N, Hui, P. Histological Parameters for Separating Diandric Triploid Partial Moles from Digynic Triploid Gestations: Is Morphological Assessment Enough?. USCAP annual meeting.
17. Niu, Na, Nagarajan, P, Galan, A. Evaluation of PD-L1 expression in Primary Cutaneous Carcinosarcomas. ASDP annual meeting.
18. Niu, Na, Hui, P, Buza, N. Aberrant Expression of INSL3, Beta-catenin, and SATB2 in Ovarian Steroid Cell and Leydig Cell Tumors. USCAP annual meeting.
19. Niu, Na, Buza, N, Hui, P. Robust Genetic Stability of Short Tandem Repeat (STR) Loci in Term Human Placentas. USCAP annual meeting.
20. Niu, Na, Salehiazar, S, Wang, M, Sun, T, Abi-Raad, R, McGregor, S, Manrai, P, Joehlin, A, Hui, P, Buza, N. Interobserver Agreement of FOLR1 Immunohistochemistry in Gynecologic Carcinomas: A Multi-Institutional Study.

Book Chapters

1. Niu, Na, Hui, P. Epithelioid trophoblast tumor. In: Gestational trophoblastic disease: Diagnostic and molecular genetic pathology (2nd Ed). Springer Press, 2025.
2. Niu, N, Liu, J. Generation of Polyploid Giant Cancer Cells (PGCCs) from Hey Ovarian Cancer Cells and Analysis of Embryonic Properties. In: Cancer cytogenetics and cytogenomics methods and protocols. Humana Press, 281-292, 2024.
3. Liang, L, Mercado-Uribe, I, Niu, Na, Zhang, J, Sood, AK, Liu, JS. Patient-derived xenograft models of ovarian/gynecologic tumors. In: Patient derived tumor xenograft model: Promise, Potential and Practice. Elsevier Press, 2016.