Natalie Wall Fowlkes, D.V.M., Ph.D., DACVP, DABT
Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine
About Dr. Natalie Fowlkes
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Veterinary Medicine and Surgery, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Veterinary Medicine and Surgery, UT MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2018 | Louisiana State University, Baton Rouge, Louisiana, US, Veterinary and Biomedical Sciences, Ph.D |
| 2010 | Louisiana State University, Baton Rouge, Louisiana, US, Veterinary Medicine, DVM |
| 2006 | Louisiana State University, Baton Rouge, Louisiana, US, Animal Science, BS |
Postgraduate Training
| 2015-2018 | Research Fellowship, Postdoctoral Fellowship in Experimental Medicine and Pathology (NIH T32), Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana |
| 2010-2013 | Clinical Residency, Anatomic Pathology, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana |
Board Certifications
| 2022 | American Board of Toxicology |
| 2016 | American College of Veterinary Pathologists |
Experience & Service
Academic Appointments
Assistant Professor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2024
Administrative Appointments/Responsibilities
Director, DISCOVER Summer Research Program, Department of Veterinary Medicine and Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Education Director (Department level), Department of Veterinary Medicine and Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Other Appointments/Responsibilities
Associate Member, MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2021 - Present
Institutional Committee Activities
Member, Faculty Senate Education Committee, 2021 - Present
Senator, Faculty Senate, 2020 - Present
Alternate Senator, Faculty Senate, 2018 - 2020
Honors & Awards
| 2017 | ACVP Young Investigator Award (Experimental Disease Division), American College of Veterinary Pathology |
| 2013 | Veterinary Pathology Scholarship Award, Charles Louis Davis, DVM Foundation for the Advancement of Veterinary and Comparative Pathology |
| 2010 | Bayer Excellence in Communication Award, LSU School of Veterinary Medicine |
| 2010 | Oncology Certificate of Excellence Award, LSU School of Veterinary Medicine |
| 2009 | LSU SCAVMA Bookstore Scholarship, LSU School of Veterinary Medicine |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Li M, Lulla AR, Wang Y, Tsavaschidis S, Wang F, Karakas C, Nguyen TD, Bui TN, Pina MA, Chen M, Mastoraki S, Multani AS, Fowlkes NW, Sahin A, Marshall C, Hunt KK, Keyomarsi AK. Low Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer. Cancer Research 84(22):3864-3880, 2024. e-Pub 2024. PMID: 39186665.
- Smetanick, D, Stolley, D, Fuentes, DA, Fowlkes, NW, Shakoor, F, Stenkamp, MS, Hicks, SC, Parrish, S, Cressman, EN. Volumetric CT Assessment of In Situ Induced Hepatic Lesions in a Transgenic Swine Model. Life 14(11), 2024. e-Pub 2024. PMID: 39598194.
- Acharya S, Basar R, Daher M, Rafei H, Li P, Uprety N, Ensley E, Shanley M, Kumar B, Banerjee PP, Melo Garcia L, Lin P, Mohanty V, Kim KH, Jiang X, Pan Y, Li Y, Liu B, Nunez Cortes AK, Zhang C, Fathi M, Rezvan A, Montalvo MJ, Cha SL, Reyes-Silva F, Shrestha R, Guo X, Kundu K, Biederstadt A, Muniz-Feliciano L, Deyter GM, Kaplan M, Jiang XR, Liu E, Jain A, Roszik J, Fowlkes NW, Solis Soto LM, Raso MG, Khoury JD, Lin P, Vega F, Varadarajan N, Chen K, Marin D, Shpall EJ, Rezvani K. CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3zeta/ZAP70 Signaling Axis. Cancer Discov 14(10):1879-1900, 2024. e-Pub 2024. PMID: 38900051.
- Barcena AJR, Perez JVD, Bernardino MR, Damasco JA, San Valentin EMD, Klusman C, Martin B, Canlas GM, Heralde FM 3rd, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Bismuth-infused perivascular wrap facilitates delivery of mesenchymal stem cells and attenuation of neointimal hyperplasia in rat arteriovenous fistulas. Biomater Adv 166:214052, 2024. e-Pub 2024. PMID: 39341164.
- Amare R, Stolley D, Parrish S, Jacobsen M, Layman R, Santos C, Riviere B, Fowlkes N, Fuentes D, Cressman E. 1D Thermoembolization Model Using CT Imaging Data for Porcine Liver. ArXiv, 2024. e-Pub 2024. PMID: 39314502.
- Shanley, M, Daher, M, Dou, J, Li, S, Basar, R, Rafei, H, Dede, M, Gumin, J, Pantaleόn Garcίa, J, Nunez Cortes, AK, He, S, Jones, C, Acharya, S, Fowlkes, NW, Xiong, D, Singh, S, Shaim, H, Hicks, SC, Liu, B, Jain, A, Zaman, MF, Miao, Q, Li, YE, Uprety, N, Liu, E, Muniz-Feliciano, L, Deyter, GM, Mohanty, V, Zhang, P, Evans, S, Shpall, EJ, Lang Jr, FF, Chen, K, Rezvani, K. Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD. Cancer cell 42(8):1450-1466.e11, 2024. e-Pub 2024. PMID: 39137729.
- Barcena, AR, Perez, JD, Bernardino, MR, San Valentin, ED, Damasco, J, Klusman, C, Martin, B, Court, KA, Godin, B, Canlas, GM, Fowlkes, NW, Bouchard, RR, Cheng, J, Huang, SY, Melancon, MP. Controlled Delivery of Rosuvastatin or Rapamycin through Electrospun Bismuth Nanoparticle-Infused Perivascular Wraps Promotes Arteriovenous Fistula Maturation. ACS Applied Materials and Interfaces 16(26):33159-33168, 2024. e-Pub 2024. PMID: 38912610.
- Lulla AR, Akli S, Karakas C, Caruso JA, Warma LD, Fowlkes NW, Rao X, Wang J, Hunt KK, Watowich SS, Keyomarsi K. Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis. Mol Cancer Ther 23(4):492-506, 2024. e-Pub 2024. PMID: 37796181.
- Pattalachinti VK, Ito I, Chowdhury S, Yousef A, Gu Y, Gunes BB, Salle ER, Taggart MW, Fournier K, Fowlkes NW, Shen JP. Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts. Mol Cancer Res 22(4):329-336, 2024. e-Pub 2024. PMID: 38226984.
- Hu Y, Revenko A, Barsoumian H, Bertolet G, Fowlkes NW, Maazi H, Green MM, He K, Sezen D, Voss TA, Leyton CSK, Masrorpour F, Rafiq Z, Puebla-Osorio N, Leuschner C, MacLeod R, Cortez MA, Welsh JW. Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy. J Exp Clin Cancer Res 43(1):70, 2024. e-Pub 2024. PMID: 38443968.
- Zacharias NM, Segarra L, Akagi K, Fowlkes NW, Chen H, Alaniz A, de la Cerda C, Pesquera P, Xi Y, Wang J, Chahoud J, Lu X, Rao P, Martinez-Ferrer M, Pettaway CA. Transcriptomic, Proteomic, and Genomic Mutational Fraction Differences Based on HPV Status Observed in Patient-Derived Xenograft Models of Penile Squamous Cell Carcinoma. Cancers (Basel) 16(5), 2024. e-Pub 2024. PMID: 38473423.
- Kezar S, Fowlkes NW, Hensel ME. Nerve sheath tumor in the forearm of a common marmoset (Callithrix jacchus). J Med Primatol 53(1):e12659, 2024. e-Pub 2024. PMID: 37340582.
- Puebla-Osorio, N, Fowlkes, NW, Barsoumian, H, Xega, K, Srivastava, G, Kettlun Leyton, C, Nizzero, S, Voss, TA, Riad, TS, Wong, C, Huang, A, Hu, Y, Mitchell, JA, Kim, M, Rafiq, Z, He, K, Sezen, D, Hsu, EY, Masrorpour, F, Maleki, A, Leuschner, C, Cortez, MA, Oertle, P, Loparic, M, Plodinec, M, Markman, JL, Welsh, J. Enhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy. Frontiers in Oncology 14, 2024. e-Pub 2024. PMID: 39445067.
- San Valentin EM, Damasco JA, Bernardino M, Court KA, Godin B, Canlas GM, Melancon A, Chintalapani G, Jacobsen MC, Norton W, Layman RR, Fowlkes N, Chen SR, Huang SY, Melancon MP. Image-Guided Deployment and Monitoring of a Novel Tungsten Nanoparticle-Infused Radiopaque Absorbable Inferior Vena Cava Filter in a Swine Model. J Vasc Interv Radiol 35(1):113-121.e3, 2024. e-Pub 2024. PMID: 37696432.
- Puebla-Osorio N, Fowlkes NW, Barsoumian HB, Xega K, Srivastava G, Kettlun-Leyton C, Nizzero S, Voss T, Riad TS, Wong C, Huang A, Hu Y, Mitchell J, Kim M, Rafiq Z, He K, Sezen D, Hsu E, Masrorpour F, Maleki A, Leuschner C, Cortez MA, Oertle P, Loparic M, Plodinec M, Markman JL, Welsh JW. Enhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy. Front Oncol 14:1407143, 2024. e-Pub 2024. PMID: 39445067.
- Klusman, C, Martin, B, Perez, JD, Barcena, AR, Bernardino, MR, Valentin, ED, Damasco, J, Del Mundo, HC, Court, KA, Godin, B, Canlas, GM, Fowlkes, NW, Bouchard, RR, Cheng, J, Huang, SY, Melancon, MP. Rosuvastatin-Eluting Gold-Nanoparticle-Loaded Perivascular Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model. Advanced Fiber Materials 5(6):1986-2001, 2023. e-Pub 2023.
- Balema, W, Morton, JE, Larson, R, Li, L, Velasquez, FC, Fowlkes, NW, Krishnamurthy, S, Debeb, BG, Sevick-Muraca, EM, Woodward, W. High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells. Journal of Mammary Gland Biology and Neoplasia 28(1), 2023. e-Pub 2023. PMID: 37801190.
- Barcena AJR, Perez JVD, Bernardino MR, Damasco JA, Cortes A, Del Mundo HC, San Valentin EMD, Klusman C, Canlas GM, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Bioresorbable Mesenchymal Stem Cell-Loaded Electrospun Polymeric Scaffold Inhibits Neointimal Hyperplasia Following Arteriovenous Fistula Formation in a Rat Model of Chronic Kidney Disease. Adv Healthc Mater 12(26):e2300960, 2023. e-Pub 2023. PMID: 37395729.
- Ito I, Yousef AMG, Chowdhury S, Dickson PN, Naini ZA, White MG, Fleten KG, Flatmark K, Fournier KF, Fowlkes NW, Shen JP. Intraperitoneal paclitaxel is a safe and effective therapeutic strategy for treating mucinous appendiceal adenocarcinoma. Cancer Res 83(19):3184-3191, 2023. e-Pub 2023. PMID: 37433032.
- Sun C, Qi Y, Fowlkes N, Lazic N, Su X, Lozano G, Wasylishen AR. The histone chaperone function of Daxx is dispensable for embryonic development. Cell Death Dis 14(8):565, 2023. e-Pub 2023. PMID: 37633949.
- Barcena AJR, Perez JVD, Damasco JA, Bernardino MR, San Valentin EMD, Klusman C, Martin B, Cortes A, Canlas GM, Del Mundo HC, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Gold Nanoparticles for Monitoring of Mesenchymal Stem-Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistula Maturation. Int J Mol Sci 24(14), 2023. e-Pub 2023. PMID: 37511512.
- Napolitano S, Woods M, Lee HM, De Falco V, Martini G, Della Corte CM, Martinelli E, Famiglietti V, Ciardiello D, Anderson A, Fowlkes NW, Villareal OE, Sorokin A, Kanikarla P, Coker O, Morris V, Altucci L, Tabernero J, Troiani T, Ciardiello F, Kopetz S. Antitumor Efficacy of Dual Blockade with Encorafenib + Cetuximab in Combination with Chemotherapy in Human BRAFV600E-Mutant Colorectal Cancer. Clin Cancer Res 29(12):2299-2309, 2023. e-Pub 2023. PMID: 37040395.
- Thompson EA, Fowlkes NW, Jacobsen MC, Layman RR, Cressman ENK. Quantitative Dual-Energy CT Image Guidance for Thermochemical Ablation: In Vivo Results in the Rabbit VX2 Model. J Vasc Interv Radiol 34(5):782-789, 2023. e-Pub 2023. PMID: 36539151.
- He K, Barsoumian HB, Puebla-Osorio N, Hu Y, Sezen D, Wasley MD, Bertolet G, Zhang J, Leuschner C, Yang L, Kettlun Leyton CS, Fowlkes NW, Green MM, Hettrick L, Chen D, Masrorpour F, Gu M, Maazi H, Revenko AS, Cortez MA, Welsh JW. Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti-PD1 in Metastatic Non-Small Cell Lung Cancer. Cancer Immunol Res 11(4):486-500, 2023. e-Pub 2023. PMID: 36700864.
- Ito I, Yousef AM, Dickson PN, Naini ZA, White MG, Fleten KG, Flatmark K, Fournier KF, Fowlkes NW, Shen JP. Antitumor activity of intraperitoneal paclitaxel in orthotopic patient-derived xenograft models of mucinous appendiceal adenocarcinoma. bioRxiv, 2023. e-Pub 2023. PMID: 36993681.
- Zhao Q, Hu J, Kong L, Jiang S, Tian X, Wang J, Hashizume R, Jia Z, Fowlkes NW, Yan J, Xia X, Yi SF, Dao LH, Masopust D, Heimberger AB, Li S. FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells. Nat Commun 14(1):735, 2023. e-Pub 2023. PMID: 36759517.
- San Valentin EM, Damasco JA, Bernardino M, Court KA, Godin B, Canlas GM, Melancon A, Chintalapani G, Jacobsen MC, Norton W, Layman RR, Fowlkes N, Chen SR, Huang SY, Melancon MP. Image-guided deployment and monitoring of a novel tungsten nanoparticleâ€"infused radiopaque absorbable inferior vena cava filter in pigs. bioRxiv, 2023. e-Pub 2023. PMID: 36798362.
- Barcena AJR, Perez JVD, Damasco JA, Bernardino MR, San Valentin EMD, Klusman C, Martin B, Cortes A, Canlas G, Del Mundo HC, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas. bioRxiv, 2023. e-Pub 2023. PMID: 36778466.
- Klusman C, Martin B, Perez JVD, Barcena AJR, Bernardino MR, San Valentin EMD, Damasco JA, Mundo HCD, Court K, Godin B, Fowlkes N, Bouchard R, Cheng J, Huang SY, Melancon MP. Rosuvastatin-Eluting Gold Nanoparticle-Loaded Perivascular Implantable Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model. bioRxiv, 2023. e-Pub 2023. PMID: 36778365.
- Pollard AC, Paolillo V, Radaram B, Qureshy S, Li L, Maity T, Wang L, Uddin MN, Wood CG, Karam JA, Pagel MD, Piwnica-Worms D, Millward SW, Fowlkes NW, Norton W, Engel BJ, Pisaneschi F, Zacharias NM. PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine. Mol Imaging Biol 24(6):959-972, 2022. e-Pub 2022. PMID: 35732988.
- More A, Ito I, Haridas V, Chowdhury S, Gu Y, Dickson P, Fowlkes NW, Shen JP. Oncogene addiction to GNAS in GNASR201 mutant tumors. Oncogene 41(35):4159-4168, 2022. e-Pub 2022. PMID: 35879396.
- Pant V, Aryal NK, Xiong S, Chau GP, Fowlkes NW, Lozano G. Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo. Cancer Res 82(7):1313-1320, 2022. e-Pub 2022. PMID: 35078816.
- Damasco JA, Huang SY, Perez JVD, Manongdo JAT, Dixon KA, Williams ML, Jacobsen MC, Barbosa R, Canlas GM, Chintalapani G, Melancon AD, Layman RR, Fowlkes NW, Whitley EM, Melancon MP. Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs. ACS Biomater Sci Eng 8(4):1676-1685, 2022. e-Pub 2022. PMID: 35343679.
- Delahoussaye AM, Abi Jaoude J, Green M, Fujimoto TN, Molkentine J, Garcia Garcia CJ, Gay JP, Feng N, Marszalek J, Fowlkes N, Taniguchi CM. Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model. BMC Cancer 22(1):174, 2022. e-Pub 2022. PMID: 35172762.
- Hu, J, Yang, Q, Zhang, W, Du, H, Chen, Y, Zhao, Q, Dao, L, Xia, X, Fowlkes, NW, Zhang, Z, Mahadeo, KM, Gorlick, R, Kopetz, S, Dotti, G, Li, S. Cell membrane-Anchored and tumor-Targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors. Journal for immunotherapy of cancer 10(1), 2022. e-Pub 2022. PMID: 35027427.
- Kanikarla Marie P, Sorokin AV, Bitner LA, Aden R, Lam M, Manyam G, Woods MN, Anderson A, Capasso A, Fowlkes NW, Overman MJ, Menter DG, Kopetz S. Autologous humanized mouse models to study combination and single-agent immunotherapy for colorectal cancer patient-derived xenografts. Front Oncol 12:994333, 2022. e-Pub 2022. PMID: 36212401.
- de Cecco BS, Carossino M, Del Piero F, Wakamatsu N, Mitchell MS, Fowlkes NW, Langohr IM. Meningoencephalomyelitis in domestic cats: 3 cases of Pasteurella multocida infection and literature review. J Vet Diagn Invest 33(6):10406387211034484, 2021. e-Pub 2021. PMID: 34301172.
- Sen A, Fowlkes NW, Kingsley CV, Kulp AM, Huynh T, Willis BJ, Brewer Savannah KJ, Bordes MCA, Hwang KP, McCulloch MM, Stafford RJ, Contreras A, Reece G, Brock KK. Technical note: Histological validation of anatomical imaging for breast modeling using a novel cryo-microtome. Med Phys 48(11):7323-7332, 2021. e-Pub 2021. PMID: 34559413.
- Park J, Tacam MJ, Chauhan G, Cohen EN, Gagliardi M, Iles LR, Ueno NT, Battula VL, Sohn YK, Wang X, Kim HS, Krishnamurthy S, Fowlkes NW, Green MM, Bartholomeusz GA, Tripathy D, Reuben JM, Bartholomeusz C. Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression. Breast Cancer Res Treat 189(2):333-345, 2021. e-Pub 2021. PMID: 34241740.
- Aslan B, Kismali G, Chen LS, Iles LR, Mahendra M, Peoples M, Gagea M, Fowlkes NW, Zheng X, Wang J, Vellano CP, Marszalek JR, Bertilaccio MTS, Gandhi V. Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL. Blood Adv 5(16):3134-3146, 2021. e-Pub 2021. PMID: 34424317.
- Shaim H, Shanley M, Basar R, Daher M, Gumin J, Zamler DB, Uprety N, Wang F, Huang Y, Gabrusiewicz K, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Mendt M, Li S, Lu J, Wei J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Kassab C, Li L, Ozcan G, Banerjee PP, Shen Y, Gilbert AL, Jones CM, Bdiwi M, Nunez-Cortes AK, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Li Y, Hu J, Draetta G, Marin D, Yu D, Mielke S, Eyrich M, Champlin RE, Chen K, Lang FF, Shpall EJ, Heimberger AB, Rezvani K. Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest 131(14), 2021. e-Pub 2021. PMID: 34138753.
- Kerbauy LN, Marin ND, Kaplan M, Banerjee PP, Berrien-Elliott MM, Becker-Hapak M, Basar R, Foster M, Garcia Melo L, Neal CC, McClain E, Daher M, Nunez Cortes AK, Desai S, Inng Lim FW, Mendt MC, Schappe T, Li L, Shaim H, Shanley M, Ensley EL, Uprety N, Wong P, Liu E, Ang SO, Cai R, Nandivada V, Mohanty V, Miao Q, Shen Y, Baran N, Fowlkes NW, Chen K, Muniz-Feliciano L, Champlin RE, Nieto YL, Koch J, Treder M, Fischer W, Okamoto OK, Shpall EJ, Fehniger TA, Rezvani K. Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies. Clin Cancer Res 27(13):3744-3756, 2021. e-Pub 2021. PMID: 33986022.
- Wu M, Xia X, Hu J, Fowlkes NW, Li S. WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression. Nat Commun 12(1):3500, 2021. e-Pub 2021. PMID: 34108491.
- Lulla AR, Akli S, Karakas C, Ha MJ, Fowlkes NW, Mitani Y, Bui T, Wang J, Rao X, Hunt KK, Meijer L, El-Naggar AK, Keyomarsi K. LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers. Oncogenesis 10(5):40, 2021. e-Pub 2021. PMID: 33990543.
- Konen JM, Rodriguez BL, Padhye A, Ochieng JK, Gibson L, Diao L, Fowlkes NW, Fradette JJ, Peng DH, Cardnell RJ, Kovacs JJ, Wang J, Byers LA, Gibbons DL. Dual inhibition of MEK and AXL targets tumor cell heterogeneity and prevents resistant outgrowth mediated by the epithelial-to-mesenchymal transition in NSCLC. Cancer Res 81(5):1398-1412, 2021. e-Pub 2021. PMID: 33402388.
- Daher M, Basar R, Gokdemir E, Baran N, Uprety N, Nunez Cortes AK, Mendt M, Kerbauy LN, Banerjee PP, Shanley M, Imahashi N, Li L, FLWI L, Fathi M, Rezvan A, Mohanty V, Shen Y, Shaim H, Lu J, Ozcan G, Ensley E, Kaplan M, Nandivada V, Bdiwi M, Acharya S, Xi Y, Wan X, Mak D, Liu E, Jiang XR, Ang S, Muniz-Feliciano L, Li Y, Wang J, Kordasti S, Petrov N, Varadarajan N, Marin D, Brunetti L, Skinner RJ, Lyu S, Silva L, Turk R, Schubert MS, Rettig GR, McNeill MS, Kurgan G, Behlke MA, Li H, Fowlkes NW, Chen K, Konopleva M, Champlin RE, Shpall EJ, Rezvani K. Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. Blood 137(5):624-636, 2021. e-Pub 2021. PMID: 32902645.
- Janke LJ, Imai DM, Tillman H, Doty R, Hoenerhoff MJ, Xu JJ, Freeman ZT, Allen P, Fowlkes NW, Iacobucci I, Dickerson K, Mullighan CG, Vogel P, Rehg JE. Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts. Vet Pathol 58(1):300985820970144, 2021. e-Pub 2021. PMID: 33208054.
- Uche IK, Fowlkes NW, Vu L, Watanabe T, Carossino M, Nabi R, Del Piero F, Rudd JS, Kousoulas KG, Rider PJF. The Novel Oncolytic Herpes Simplex Virus Type-1 (HSV-1) VC2 Promotes Long-lasting, Systemic Anti-melanoma Tumor Immune Responses and Increased Survival in an Immunocompetent B16F10-derived Mouse Melanoma Model. J Virol 95(3), 2021. e-Pub 2021. PMID: 33177208.
- Kanikarla Marie P, Fowlkes NW, Afshar-Kharghan V, Martch SL, Sorokin A, Shen JP, Morris VK, Dasari A, You N, Sood AK, Overman MJ, Kopetz S, Menter DG. The Provocative Roles of Platelets in Liver Disease and Cancer. Front Oncol 11:643815, 2021. e-Pub 2021. PMID: 34367949.
- Mendt M, Daher M, Basar R, Shanley M, Kumar B, Wei Inng FL, Acharya S, Shaim H, Fowlkes NW, Tran JP, Gokdemir E, Uprety N, Nunez-Cortes AK, Ensley E, Mai T, Kerbauy LN, Melo-Garcia L, Lin P, Shen Y, Mohanty V, Lu J, Li S, Nandivada V, Wang J, Banerjee P, Reyes-Silva F, Liu E, Ang S, Gilbert A, Li Y, Wan X, Gu J, Zhao M, Baran N, Muniz-Feliciano L, Wilson J, Kaur I, Gagea M, Konopleva M, Marin D, Tang G, Chen K, Champlin R, Rezvani K, Shpall EJ. Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD. Front Immunol 12:631353, 2021. e-Pub 2021. PMID: 34017325.
- Moyer SM, Wasylishen AR, Qi Y, Fowlkes N, Su X, Lozano G. p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo. Proc Natl Acad Sci U S A 117(38):23663-23673, 2020. e-Pub 2020. PMID: 32900967.
- Basar R, Daher M, Uprety N, Gokdemir E, Alsuliman A, Ensley E, Ozcan G, Mendt M, Hernandez Sanabria M, Kerbauy LN, Nunez Cortes AK, Li L, Banerjee PP, Muniz-Feliciano L, Acharya S, Fowlkes N, Lu J, Li S, Mielke S, Kaplan M, Nandivada V, Bdaiwi M, Kontoyiannis AD, Li Y, Liu E, Ang S, Marin D, Brunetti L, Gundry MC, Turk R, Schubert MS, Rettig GR, McNeill MS, Kurgan G, Behlke MA, Champlin R, Shpall EJ, Rezvani K. Large-scale GMP-compliant CRISPR-Cas9-mediated deletion of the glucocorticoid receptor in multivirus-specific T cells. Blood Adv 4(14):3357-3367, 2020. e-Pub 2020. PMID: 32717029.
- Casal RF, Schwalk AJ, Fowlkes N, Aburto RR, Norton W, Dixon KA, Lin S, Shaitelman SF, Chintalapani G, Hill L. Endobronchial ultrasound-guided injection of NBTXR3 radio enhancing nanoparticles into mediastinal and hilar lymph nodes: a swine model to evaluate feasibility, injection technique, safety, nanoparticle retention and dispersion. J Thorac Dis 12(5):2317-2324, 2020. e-Pub 2020. PMID: 32642136.
- Fowlkes N, Clemons K, Rider PJ, Subramanian R, Wakamatsu N, Langohr I, Kousoulas KG. Factors Affecting Growth Kinetics and Spontaneous Metastasis in the B16F10 Syngeneic Murine Melanoma Model. Comp Med 69(1):1-7, 2019. e-Pub 2019. PMID: 30563585.
- Leissinger MK, McCauley C, Fowlkes N, Grasperge BJ. What is your diagnosis? Nasal lesion in a horse. Vet Clin Pathol 46(2):361-362, 2017. e-Pub 2017. PMID: 28249099.
- Le Donne V, Crossland N, Brandão J, Sokolova Y, Fowlkes N, Nevarez JG, Langohr IM, Gaunt SD. Nannizziopsis guarroi infection in 2 Inland Bearded Dragons (Pogona vitticeps): clinical, cytologic, histologic, and ultrastructural aspects. Vet Clin Pathol 45(2):368-375, 2016. e-Pub 2016. PMID: 27010762.
- Evans D, Fowlkes N. Renal leiomyosarcoma in a cat. J Vet Diagn Invest 28(3):315-8, 2016. e-Pub 2016. PMID: 26975352.
- Sumner JP, Pucheu-Haston CM, Fowlkes N, Merchant S. Dorsal skin necrosis secondary to a solar-induced thermal burn in a brown-coated dachshund. Can Vet J 57(3):305-8, 2016. e-Pub 2016. PMID: 26933270.
- Leissinger MK, Garber JB, Fowlkes N, Grooters AM, Royal AB, Gaunt SD. Mycobacterium fortuitum lipoid pneumonia in a dog. Vet Pathol 52(2):356-9, 2015. e-Pub 2015. PMID: 24788402.
- Doss GA, Nevarez JG, Fowlkes N, da Cunha AF. Evaluation of metomidate hydrochloride as an anesthetic in leopard frogs (Rana pipiens). J Zoo Wildl Med 45(1):53-9, 2014. e-Pub 2014. PMID: 24712162.
- Brandão J, Woods S, Fowlkes N, Leissinger M, Blair R, Pucheu-Haston C, Johnson J, Elster Phillips C, Tully T. Disseminated histoplasmosis (Histoplasma capsulatum) in a pet rabbit: case report and review of the literature. J Vet Diagn Invest 26(1):158-62, 2014. e-Pub 2014. PMID: 24452788.
- Gupta A, Garber J, Fowlkes N, Rademacher N, Shiomitsu K, Evans DE, Gaunt SD. What is your diagnosis? Abdominal fluid from a dog. Vet Clin Pathol 42(1):113-4, 2013. e-Pub 2013. PMID: 23083469.
- Gumber S, Fowlkes N, Cho DY. Disseminated sclerosing peritoneal mesothelioma in a dog. J Vet Diagn Invest 23(5):1046-50, 2011. e-Pub 2011. PMID: 21908373.
- Scollard DM, Chaduvula MV, Martinez A, Fowlkes N, Nath I, Stryjewska BM, Kearney MT, Williams DL. Increased CXC ligand 10 levels and gene expression in type 1 leprosy reactions. Clin Vaccine Immunol 18(6):947-53, 2011. e-Pub 2011. PMID: 21508169.
Abstracts
- Fowlkes NW. Transcriptomic, Proteomic, And Genomic Mutational Fraction Differences Based On HPV Status Observed In Patient Derived Xenograft Models Of Penile Squamous Cell Carcinoma. Urology, 2024. e-Pub 2024.
- Fowlkes NW, Cho KS, Soeung M, Anderson A, Alshenaifi J, Manyam G, Villareal O, Davis J, Norton W, Gao S, Bristow C, Carbone F, Napolitano S, Coker O, Khanduri I, Huang J, Maru DM, Pilato MD, Sun R, Wang L, Menter DG, Genovese G, Draetta G, Fowlkes N, Kopetz S. Anti-CSF1R antibody monotherapy inhibits minimal residual disease in a novel immunocompetent murine colorectal cancer metastasis model. Cancer Research 84(6):1168, 2024. e-Pub 2024.
- Villarreal OE, Lee HM, Tran H, Machado A, Alshenaifi J, Wong CW, Coker O, Minelli R, Peoples M, Martinez AH, Fowlkes N, Kanikarla P, Lin K, Bristow C, Viale A, Marszalek JR, Shen JP, Kopetz S. ASCL2+ tumor cells modulate the response of colorectal cancer to MAPK targeting therapy. Cancer Research 84(7), 2024. e-Pub 2024.
- Tan AW, Mughees M, Woodward WA, Tripathy D, Fowlkes N, Bartholomeusz C. PEA-15 phosphorylation mediates pro-tumor effects by promoting β-catenin activity in TNBC. Cancer Research, 2024. e-Pub 2024.
- Cortes AC, Minamiguchi K, Kostan H, Stenkamp MS, Anfossi S, Fowlkes NW, Avritcsher R. Non-invasive monitoring of tumor biomechanics and implications for immunotherapy in HCC. Cancer Research 84(6):5547, 2024. e-Pub 2024.
- Smetanick D, Stolley D, Fuentes D, Fowlkes NW, Shakoor F, Stenkamp MS, Hicks S, Parrish S, Cressman E. Volumetric CT Assessment of In Situ Induced Hepatic Lesions of an Oncopig Model. Vacular and Interventional Radiology 35(3):S209, 2024. e-Pub 2024.
- Pattalachinti VK, Pattalachinti VK, Ito I, Ito I, Chowdhury S, Chowdhury S, Yousef A, Yousef A, Gu Y, Gu Y, Gunes BB, Gunes BB, Salle ER, Salle ER, Taggart MW, Taggart MW, Fournier K, Fournier K, Fowlkes NW, Fowlkes NW, Shen JP, Shen JP. Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts. Cancer Research 22(4):329-336, 2024. e-Pub 2024.
- Puebla N, Srivastava G, Nizzero S, Fowlkes NW, Barsoumian H, Hu Y, Leuschner C, Riad T, Loparic M, Plodinec M, Welsh J. Enhanced tumor control and survival in solid tumor models following combined low dose radiotherapy and T cell therapy. Cancer Research 84(6):97, 2024. e-Pub 2024.
- Abana CO, Palmiero AN, Liu K, Green MM, Li Z, Harris L, Mayor S, Samuel KQ, Younkin RA, Moore EJ, Norton W, Swain J, Fowlkes NW, Koong AC, Woodward WA, Taniguchi CM, Beddar S, Mitra D, Schueler E, Lin SH. Subacute Cutaneous Toxicity with Single-Fraction Electron FLASH RT in Yorkshire Swine. International Journal of Radiation Oncology, Biology, Physics, 117(2):S10-S11, 2023. e-Pub 2023.
- Mohamed AM, Soeung M, Alshenaifi J, Fowlkes NW, Manyam G, Davis J, Anderson A, Norton W, Deem AK, Gao S, Khanduri I, Bistow C, Carbone F, Napolitano S, Huang J, Maru DM, Menter DG, Draetta GF, Genovese G, Kopetz S. Recapitulating metastatic colorectal cancer in somatic mutation models for investigating the tumor immune microenvironment in minimal residual disease. Cancer Research 83(7_Supplement):77-77, 2023. e-Pub 2023.
- Green MM, Fujimoto T, Taniguchi C, Fowlkes NW. Modeling age-related changes in the tumor microenvironment in an orthotopic immunocompetent murine pancreatic cancer model-a novel approach. Cancer Research 83(7_Supplement):5191-5191, 2023. e-Pub 2023.
- Cortes AC, Minamiguchi K, Costa Lopez PLD, Anfossi S, Williams Malea L, Stenkamp MS, Avritscher R, Fowlkes NW. Vimentin content associated with shear wave speed in hepatocellular carcinoma: Non-invasive identification of more aggressive tumor phenotypes. Cancer Research 83(7_Supplement):5852-5852, 2023. e-Pub 2023.
- Barcena J, Perez J, Bernardino M, Damasco J, Valentin E, Mundo H, Cortes A, Canlas G, Chen J, Avritscher R, Fowlkes NW, Huang S, Melancon M. Bioresorbable Mesenchymal Stem Cell-Loaded Electrospun Polymeric Scaffold Inhibits Neointimal Hyperplasia in a Rat Model of Arteriovenous Fistula. Journal of Vascular and Interventional Radiology 34(3):S16-17, 2023. e-Pub 2023.
- Balema W, Krishnamurthy S, Lawrence A, Rodriguez M, Larson R, Fowlkes NW, Ueno NT, Woodward W. CCR7 expression in Inflammatory breast cancer. Cancer Research 83(5_Supplement):P2-26-15-P2-26-15, 2023. e-Pub 2023.
- Valentin E, Damasco J, Bernardino M, Honegger S, Court K, Godin B, Canlas G, Chintalapani G, Norton W, Chen S, Fowlkes NW, Huang S, Melancon M. In Vivo Imaging of Novel Tungsten Nanoparticle and Polymer-Infused Resorbable Inferior Vena Cava Filters in Porcine Model. Journal of Vascular and Interventional Radiology 34(3):S123-S124, 2023. e-Pub 2023.
- Mastoraki S, Lulla AR, Schneider S, Clise-Dwyer K, Green MM, Fowlkes NW, Hunt KK, Watowich SS, Keyomarsi K. LMW-E induction and crosstalk with immune cells potentiates local immune responses leading to an immunosuppressive microenvironment at the early stages of breast tumorigenesis in mouse models. Cancer Research 82(12_Supplement):1348, 2022. e-Pub 2022.
- Lulla AR, Akli S, Warma LD, Fowlkes NW, Hunt KK, Rao X, Wang J, Watowich SS, Keyomarsi K. Neutrophil elastase (NE) inhibition enhances metastasis free survival by altering regulation of tumor intrinsic cytoskeletal and cellular adhesion pathways in murine breast cancer models. Cancer Research 82(12_Supplement):264, 2022. e-Pub 2022.
- Segarra LA, Zacharias NM, Pieretti A, Alaniz A, Maity T, Martinez S, Rao P, Fowlkes NW, Chahoud J, Lu X, Ferrer MM, Wood C, Pettaway C. Establishment of patient-derived xenografts in penile cancer. Cancer Research 82(12_Supplement):3111, 2022. e-Pub 2022.
- Akli S, Lulla AR, Saenz FR, Wang F, Fowlkes NW, Bui T, Wang Y, Mastoraki S, Ha MJ, Hunt KK, Keyomarsi K. Aurora kinase is an actionable target in low molecular weight cyclin E induced mammary tumors. Cancer Research 82(12_Supplement):2592, 2022. e-Pub 2022.
- Uche IK, Fowlkes NW, Vu L, Watanabe T, Carossino M, Nabi R, Piero FD, Rudd JS, Kousoulas KG, Rider PJ. VC2 Oncolytic Virotherapy Induces Robust Systemic Anti-Tumor Immunity and Increases Survival in an Immunocompetent B16F10-derived Mouse Melanoma Model. Journal of Clinical and Translational Science 5(s1):13-14, 2021. e-Pub 2021.
- Hu JM, Zhang WD, Xia XQ, Yang Q, Chen YH, Fowlkes NW, Livingston JA, Zhang ZT, Mahadeo KM, Gill JB, Dotti G, Kopetz S, Gorlick R, Li SL. CRS free T cell therapy: T cell membrane anchored and tumor targeted IL12 (ATTIL12)-T cell therapy eliminates large tumors, overcomes heterogeneity, and avoids adverse effects. Journal of Immunology 204(1), 2020. e-Pub 2020.
- Kerbauy L, Marin N, Kaplan M, Banerjee P, Berrien-Elliott M, Becker-Hapak M, Basar R, Foster M, Melo LG, Neal C, McClain E, Daher M, Nunez Cortes AK, Desai S, Inng Lim FW, Mendt MC, Schappe T, Li L, Shaim H, Sanabria MH, Wong P, Liu E, Ang S, Cai R, Nandivada V, Mohanty V, Shen Y, Baran N, Fowlkes NW, Chen K, Muniz-Feliciano L, Koch J, Treder M, Fischer W, Okamoto OK, Nieto Y, Champlin R, Shpall E, Fehniger T, Rezvani K. AFM13-Targeted Blood and Cord-Blood-Derived Memory-Like NK Cells as Therapy for CD30+ Malignancies. Journal for ImmunoTherapy of Cancer 8(Suppl 3), 2020. e-Pub 2020.
- Fowlkes NW, Swain J, Gagea M, Lockworth C, Tinkey P, Jensen V, Whitley EM. Cutaneous and Gastrointestinal Dysbiosis in Immunodeficient Mice. FASEB Journal 33(1S), 2019. e-Pub 2019.
- Scollard DM, Fowlkes NW, Martinez A, Chaduvula M, Nath I, Strjewska B, Williams D. Reversal Reaction in Leprosy is Associated with Increased CXCL10 Production. The FASEB Journal 23:1003.12-1003.12, 2009. e-Pub 2009.
- Scollard DM, Martinez A, Chaduvula M, Fowlkes N, Nath I, Stryjewska B, Williams DL. Increased CXCL10 Is Associated with Reversal Reaction in Leprosy. Laboratory Investigation 89:297A-297A, 2009. e-Pub 2009.
Selected Presentations & Talks
Local Presentations
- 2024. Exploring the Role of CXCR2 in Brain Metastasis in Murine Models of Inflammatory Breast Cancer Using Multiplex Immunofluorescence. Poster. CATALYST Summer Student Syposium. Houston, Texas, US.
- 2024. Clinicopathologic Evaluation of Radiation-Induced Skin Toxicity in a Porcine Model. Poster. CATALYST Summer Student Symposium. Houston, Texas, US.
- 2023. Inflammatory Pseudotumors Induced by AdCre in Transgenic Oncopigs After In Situ Tumor Induction. Poster. CATALYST Summer Student Symposium. Houston, Texas, US.
- 2023. Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth in Preclinical PDX Models. Poster. CATALYST Summer Student Symposium. Houston, Texas, US.
- 2023. Tumor Stiffness is Associated with Reduced CD45+ Immune Cell Penetration of Tumors in a Rat Hepatocellular Carcinoma Model. Poster. CATALYST Summer Student Symposium. Houston, Texas, US.
- 2022. Clinicopathologic characterization of a multi-organ in situ tumor induction strategy in an oncopig model. Poster. Summer Experience Symposium. Houston, TX, US.
- 2022. Tungsten nanoparticle and polymer blends as novel coating for radiopaque resorbable inferior vena cava filter. Poster. Summer Experience Research Symposium. Houston, TX, US.
- 2022. CCR7 immune cell receptor expression in inflammatory breast cancer. Poster. Summer Experience Symposium. Houston, TX, US.
Regional Presentations
- 2024. Neuropathologic Analysis of IL-15-Engineered NK Cell Therapy in a Murine Glioblastoma Model. Conference. Texas A&M Veterinary Medical Scientist Research Training Program Symposiun. College Station, TX, US.
- 2022. CCR7 expression in inflammatory breast cancer. Poster. San Antonio Breast Cancer Symposium, US.
- 2022. Struvite urolithiasis in a Tg(KRT14-cre)1Amc/J mouse. Poster. Texas Branch of the American Association of Laboratory Animal Science (TBAALAS), US.
- 2017. Evaluation of the HSV-1 Live-Attenuated VC2 Vaccine Strain as Oncolytic Immunomodulatory Virotherapy in a Murine Melanoma Model. Poster. Phi Zeta Research Emphasis Day. Baton Rouge, LA, US.
- 2017. Leiomyosarcoma in a Captive Tiger (Panthera tigris). Poster. Phi Zeta Research Emphasis Day. Baton Rouge, LA, US.
- 2017. Characterization of immune responses during tumor progression versus engraftment failure in a novel, immunocompetent double-labeled murine melanoma model. Conference. Louisiana Biomedical Research Network (LBRN) Summer Research Program. Baton Rouge, LA, US.
- 2017. Development of a novel immunocompetent murine melanoma model using double-labeled B16F10 murine melanoma cells. Conference. Louisiana Biomedical Research Network (LBRN) Summer Research Program. Baton Rouge, LA, US.
- 2012. Necrotizing fasciitis in a dog. Conference. Graduate Student Research Symposium. Baton Rouge, LA, US.
- 2011. A case of Hepatozoonosis and systemic amyloidosis in a dog. Conference. Graduate Student Symposium. Baton Rouge, LA, US.
National Presentations
- 2024. Clinicopathologic Evaluation of Radiation-Induced Skin Toxicity in a Porcine Model. Poster. American College of Veterianry Pathologists. Seattle, WA, US.
- 2024. Neuropathologic Analysis of IL-15-Engineered NK Cell Therapy in a Murine Glioblastoma Model. Conference. American College of Veterinary Pathologists. Seattle, WA, US.
- 2024. Non-invasive monitoring of tumor biomechanics and implications for immunotherapy in HCC. Poster. American Association of Cancer Research (AACR). San Diego, CA, US.
- 2024. ASCL2+ tumor cells modulate the response of colorectal cancer to MAPK targeting therapy. Poster. American Association of Cancer Research (AACR). San Diego, CA, US.
- 2024. Anti-CSF1R antibody monotherapy inhibits minimal residual disease in a novel immunocompetent murine colorectal cancer metastasis model. Poster. American Association of Cancer Research (AACR). San Diego, CA, US.
- 2024. Enhanced tumor control and survival in solid tumor models following combined low dose radiotherapy and T cell therapy. Poster. American Association of Cancer Research (AACR). San Diego, CA, US.
- 2023. Appendiceal Adenocarcinoma PDX Models Have Improved Tumor Growth in an Orthotopic Tumor Environment. Conference. American College of Veterinary Pathologists. Chicago, IL, US.
- 2023. Pathologic Characterization of Adenovirus-Cre-induced Liver Lesions in Transgenic Oncopigs. Poster. American College of Veterinary Pathologists. Chicago, IL, US.
- 2023. A Rat Hepatocellular Carcinoma Model for Investigating Molecular Phenotypes Associated with Tumor Stiffness. Conference. American College of Veterinary Pathologists. Chicago, IL, US.
- 2023. Subacute Cutaneous Toxicity After Single-Fraction Electron FLASH RT in Yorkshire Swine. Conference. American Society for Radiation Oncology (ASTRO). San Diego, CA, US.
- 2023. Struvite Urolithiasis in a Tg(KRT14-cre)1Amc/J Mouse. Poster. American Association of Laboratory Animal Science (ALAAS). Salt Lake City, UT, US.
- 2023. Correlation of MR Imaging with Histology to Determine Anatomical Characteristics of the Breast Fascial System Using a Novel Cryo-Fluorescent Imager. Conference. American Association of Physicists in Medicine (AAPM). Houston, TX, US.
- 2023. Single-Fraction Electron Flash: Subacute Cutaneous Toxicity Analysis Via Swine Models. Conference. American Association of Physicists in Medicine (AAPM). Houston, TX, US.
- 2023. Initial Results from Mass Spectrometry Imaging Characterization of Liver Tumor Development in the Oncopig Model. Conference. American Society for Mass Spectrometry (ASMS). Santa Fe, NM, US.
- 2023. Mapping distribution of an alkylamine in tissue for restoration of an Immune-permissive microenvironment. Conference. American Society for Mass Spectrometry (ASMS). Santa Fe, NM, US.
- 2023. Feasibility Study of Alkaline Solutions in Embolotherapy. Conference. Global Embolization Symposium Technologies (GEST). New York City, NY, US.
- 2023. Preclinical Studies Using a Biopsy Tract Sealing and Fiducial Device. Conference. Global Embolization Symposium Technologies (GEST). New York City, NY, US.
- 2023. Initial Experience with an inducible transgenic tumor model in Swine. Conference. Global Embolization Symposium Technologies (GEST). New York City, NY, US.
- 2023. Recapitulating metastatic colorectal cancer in somatic mutation models for investigating the tumor immune microenvironment in minimal residual disease. Poster. American Association of Cancer Research (AACR). Orlando, FL, US.
- 2023. Tuning Thermal and Ablative Effects of Acid Anhydrides in Thermoembolization. Conference. Society for Thermal Medicine (STM). San Diego, CA, US.
- 2023. Liver tumor or liver tumor? Initial Experience with the Oncopig for Hyperthermic Therapies. Conference. Society for Thermal Medicine (STM). San Diego, CA, US.
- 2023. Modeling age-related changes in the tumor microenvironment in an orthotopic immunocompetent murine pancreatic cancer model-a novel approach. Poster. American Association of Cancer Research (AACR). Orlando, FL, US.
- 2023. Vimentin content associated with shear wave speed in hepatocellular carcinoma: Non-invasive identification of more aggressive tumor phenotypes. Poster. American Association of Cancer Research (AACR). Orlando, FL, US.
- 2023. Abstract No. 273 In Vivo Imaging of Novel Tungsten Nanoparticle and Polymer-Infused Resorbable Inferior Vena Cava Filters in Porcine Model. Conference. Society for Interventional Radiology (SIR). Phoenix, AZ, US.
- 2023. Abstract No. 31 Bioresorbable Mesenchymal Stem Cell-Loaded Electrospun Polymeric Scaffold Inhibits Neointimal Hyperplasia in a Rat Model of Arteriovenous Fistula. Conference. Society of Intervential Radiology (SIR). Phoenix, AZ, US.
- 2023. Antitumor activity of intraperitoneal (IP) paclitaxel to mucinous appendiceal adenocarcinoma in orthotopic patient-derived xenograft model. Poster. American Association of Clinical Oncology (ASCO). San Francisco, CA, US.
- 2022. Abstract P2-26-15: CCR7 expression in Inflammatory breast cancer. Poster. AACR San Antonio Breast Cancer Symposium. San Antonio, TX, US.
- 2022. Development of multiplex immunofluorescent panels for studying the immunobiology of metastatic colorectal cancer and minimal residual disease. Poster. American College of Veterinary Pathologists (ACVP). Boston, MA, US.
- 2022. Modeling age-related changes in the tumor microenvironment in an immunocompetent orthotopic murine pancreatic cancer model-a novel approach. Poster. American College of Veterinary Pathologists (ACVP). Boston, MA, US.
- 2022. Hepatic histiocytic proliferation arising in an immunocompetent murine model of colorectal cancer. Poster. American College of Veterinary Pathologists (ACVP). Boston, MA, US.
- 2022. PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine. Conference. World Molecular Imaging Congress. Miami, FL, US.
- 2022. Somatic mutation models recapitulating metastatic colorectal cancer to study tumor immune microenvironment in minimal residual disease. Poster. Mechanisms and Models of Disease. Long Island, NY, US.
- 2022. Neutrophil elastase (NE) inhibition enhances metastasis free survival by altering regulation of tumor intrinsic cytoskeletal and cellular adhesion pathways in murine breast cancer models. Poster. American Association of Cancer Research (AACR). New Orleans, LA, US.
- 2022. LMW-E induction and crosstalk with immune cells potentiates local immune responses leading to an immunosuppressive microenvironment at the early stages of breast tumorigenesis in mouse models. Poster. American Association of Cancer Research (AACR). New Orleans, LA, US.
- 2022. Establishment of patient-derived xenografts in penile cancer. Poster. American Association of Cancer Research (AACR). New Orleans, LA, US.
- 2022. Aurora kinase is an actionable target in low molecular weight cyclin E induced mammary tumors. Poster. American Association of Cancer Research (AACR). New Orleans, LA, US.
- 2021. 45724 VC2 Oncolytic Virotherapy Induces Robust Systemic Anti-Tumor Immunity and Increases Survival in an Immunocompetent B16F10-derived Mouse Melanoma Model. Conference. Association for Clinical and Translational Science (ACTS). Virtual, US.
- 2020. 531 AFM13-targeted blood and cord-blood-derived memory-like NK cells as therapy for CD30+ malignancies. Conference. Society for Immunotherapy of Cancer (SITC). Virtual, US.
- 2019. Cutaneous and Gastrointestinal Dysbiosis in Immunodeficient Mice. Conference. Experimental Biology (ASIP). Orlando, FL, US.
- 2016. Development of a syngeneic immunoompetent mouse model system for testing novel oncolytic herpes simplex virus type-1 for the treatment of melanoma. Conference. American College of Veterinary Pathologists (ACVP). New Orleans, LA, US.
- 2016. Development of a syngeneic immunocompetent mouse model system for testing novel oncolytic herpes simplex virus type-1 for teh treatment of melanoma. Poster. 41st Annual International Herpesvirus Workshop. Madison, WI, US.
- 2013. "Pathology of Lumps and Bumps". Invited. Student American Veterinary Medical Association. Baton Rouge, LA, US.
- 2012. A Neuropathology Mystery Solved (Angiostrongylus cantonensis). Conference. American College of Veterinary Patologists (ACVP). Seattle, WA, US.
- 2012. Evaluation of metomidate hydrochloride as an anesthetic in leopar frogs (|IRana pipiens). Conference. American Association of Zoo Veterinarians. Oakland, CA, US.
- 2012. Facial swelling in a horse (ameloblastic carcinoma). Conference. Southeastern Veterinary Pathology Conference. Tifton, GA, US.
- 2011. Renal leiomyosarcoma in a cat. Poster. American College of Veterinary Pathologists (ACVP). Nashville, TN, US.
- 2011. Sudden death in bearded dragons. Conference. Southeastern Veterinary Pathology Conference. Tifton, GA, US.
International Presentations
- 2023. Examining the acute and long-tern response of normal tissue irradiated in FLASH and CONV RT. Conference. International Congress for Radiation Research (ICRR). Montreal, CA.
- 2017. A syngeneic immunocompetent double-labeled B16F10 murine melanoma model for efficacy and safety testing of oncolytic virotherapy using the HSV-1 VC2 live-attenuated vaccine strain. Conference. American College of Veterinary Pathologists (ACVP). Vancouver, CA.
- 2017. A syngeneic immunocompetent mouse model system for oncolytic virotherapy of metastatic melanoma using the HSV-1 VC2 live-attenuated vaccine strain. Conference. International Herpesvirus Workshop. Ghent, BE.
- 2013. Ichthyophonus-like disease in a Northern Leopard Frog (Rana pipiens). Conference. International Conference on Avian, Herpetological, and Exotic Mammal Medicine. Wiesbaden, DE.
Grant & Contract Support
| Date: | 2025 - 2030 |
| Title: | Nanoparticle- Infused Radiopaque Absorbable Medical Device |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2025 - 2028 |
| Title: | A Novel Therapeutic Strategy Targeting Metastasis of Neuroendocrine Prostate Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| Date: | 2024 - 2027 |
| Title: | The Epigenetic Modifier UTX in HER2-positive Breast Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2027 |
| Title: | Discovering Novel Oncoproteins Linked to KMT2D Loss in Gastric Adenocarcinoma |
| Funding Source: | Department of Defense (DOD) |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2029 |
| Title: | KDM4A in the Metastasis of Neuroendocrine Prostate Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2024 - 2028 |
| Title: | Targeting of Cancer Stem cells by inhibiting MELK in Aggressive Breast Cancers |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Multimodal Imaging to Determine Anatomical Characteristics of the Breast Fascial System |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2024 |
| Title: | Mechanisms of Cholesterol-Mediated and Radiation Resistance |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Mesenchymal Stem Cell-Loaded Biopolymeric Scaffolds for Augmenting the Preoperative Liver Growth |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2029 |
| Title: | Defining and Targeting Alterations of the Epigenetic Modifier KMT2D in Non-Small Cell Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2027 |
| Title: | JARID1D and its Corepressors in Regulation of Prostate Cancer Metastasis |
| Funding Source: | Department of Defense (DOD) |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2029 |
| Title: | The Epigenetic Modifier JARID1D and its Corepressors in Regulation of Prostate Cancer Metastasis |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2029 |
| Title: | Identifying Novel Oncoproteins Linked to KMT2D Loss in Gastric Adenocarcinoma |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2025 |
| Title: | Role of MELK as a novel therapeutic target in aggressive breast cancers |
| Funding Source: | ELSA U PARDEE FOUNDATION |
| Role: | Co-I |
| Date: | 2024 |
| Title: | Transcatheter Chemistry: A Novel Approach In Image-Guided Therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Toward Clinical Monitoring of Tumor Stromal Dynamics Using Integrated Quantitative Ultrasound Applications |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2029 |
| Title: | Oncogenic Role of Aberrant ZFY Expression in Medulloblastoma |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2029 |
| Title: | MELK as a Driver of Progression and Metastasis in Aggressive Breast Cancers |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Translating advanced approaches to precision targeting of KRAS mutated cancers |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2024 - 2027 |
| Title: | JARID1D and its Corepressors in Regulation of Prostate Cancer Metastasis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Other Significant Contributor |
| Date: | 2024 - 2027 |
| Title: | Targeting of Cancer Stem cells by inhibition of MELK in Aggressive Breast Cancers |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Co-I |
| Date: | 2023 - 2030 |
| Title: | Nanoparticle-Enhanced Absorbable Medical Devices for Management of Vascular Diseases |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2025 |
| Title: | Targeted Reversal of Acidic pH in the Tumor Microenvironment |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2025 |
| Title: | The Epigenetic Modifier UTX, Breast Cancer, and Drug Resistance |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-I |
| Date: | 2023 - 2024 |
| Title: | Aberrant MLL4-ZFY Axis in Medulloblastoma |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Developing a novel combination immunotherapy for triple-negative breast cancer |
| Funding Source: | University of Hawaii Cancer Center |
| Role: | Co-I |
| Date: | 2023 - 2024 |
| Title: | Developing Clinically Relevant Genetic Mouse Models for Upper Track Urothelial Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | The Histone Modifier UTX in Triple-Negative and HER2-Positive Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2023 - 2028 |
| Title: | In Vivo Chemistry as a New Approach to Treat Solid Tumors |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | MELK as a Driver of Progression and Metastasis in Aggressive Breast Cancers |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Development of mutant PEA-15 as a novel therapeutic for triple-negative breast cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Developing a novel combination immunotherapy for triple-negative breast cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | Reactive Embolization for Selective and Effective Treatment of Solid Tumors |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2023 - 2028 |
| Title: | The Histone Modifier UTX, Breast Cancer, and Drug Resistance |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2023 - 2028 |
| Title: | In Vivo Chemistry as a New Approach to Treat Solid Tumors |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2023 - 2026 |
| Title: | Enhancing Immune Responses in Pancreatic Cancer by Stromal Inhibition of HIF2 |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Date: | 2023 - 2025 |
| Title: | Cis-aconitate decarboxylase (ACOD1) as a therapeutic target in immunosuppressive PMN-MDSC's |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| Date: | 2023 - 2026 |
| Title: | PEA-15 Gene Therapy for Aggressive Breast Cancers |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Date: | 2023 - 2026 |
| Title: | The Epigenetic Modifier UTX, Breast Cancer, and Drug Resistance |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Date: | 2023 - 2026 |
| Title: | Advanced approaches to understanding and targeting BRAF tumors |
| Funding Source: | Gastro-Intestinal Research Foundation |
| Role: | Collaborator |
| ID: | AWD0007261 |
| Date: | 2023 - 2026 |
| Title: | Targeting of Cancer Stem cells by inhibition of MELK in Aggressive Breast Cancers |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Co-I |
| Date: | 2022 - 2024 |
| Title: | Engineered Extracellular Vesicles to Modulate immunotherapy in Liver Cancer |
| Funding Source: | Society of Interventional Oncology |
| Role: | Co-I |
| Date: | 2022 - 2025 |
| Title: | The Role of MELK in Stromal Reorganization of Aggressive Breast Cancers |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-I |
| ID: | BC220287 |
| Date: | 2022 - 2027 |
| Title: | Cis-aconitate decarboxylase (ACOD1) in PMN-MDSC and prostate cancer progression |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | The Role of HIF2 in Pancreatic Ductal Adenocarcinoma |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | Translating FLASH Radiobiological Insights to Cutaneous Malignancies |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | Image-guided therapy for liver cancer |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2022 - 2023 |
| Title: | Strategies to restore an immune-permissive microenvironment |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2022 - 2027 |
| Title: | KDM4A in the Metastasis of Neuroendocrine Prostate Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | Heterozygous KMT2D Loss and Medulloblastoma |
| Funding Source: | NIH/NCI |
| Role: | Consult |
| ID: | 1R01CA262324-01A1 |
| Date: | 2022 - 2027 |
| Title: | Epigenome reporgramming and targeting in aggressive variant prostate cancers |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2023 |
| Title: | Determination of the Toxicity Equivalent Dose and Effective Fractionation Regimen For FLASH-RT on the IntraOp Mobetron Electron FLASH Unit Designed For Clinical Utilization |
| Funding Source: | Radiological Society of North America (RSNA) |
| Role: | Other Significant Contributor |
| Date: | 2022 - 2027 |
| Title: | The Epigenetic Modifier UTX in Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2023 |
| Title: | FLASH Radiation Therapy Optimization on Clinically Relevant Volumes of Pig Skin Using The IntraOp® Electron FLASH Mobetron® Designed for Clinical Use |
| Funding Source: | American Society for Therapeutic Radiology and Oncology (ASTRO) |
| Role: | Other Significant Contributor |
| Date: | 2022 - 2027 |
| Title: | Biodegradable Radiopaque Polymeric Scaffolds Loaded with Mesenchymal Stem Cells for Image-Guided Arteriovenous Fistula Maturation and Long-Term Patency |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1RO1HL159960-01A1 |
| Date: | 2022 - 2024 |
| Title: | Characterization of endovascular ablative therapies with computational modeling |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | Therapeutic approaches for TGF-beta-enriched minimal residual disease in patients with colorectal cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2022 - 2027 |
| Title: | Combining Heat, Hypoxia, Drugs, Reource Depletion, and Protons: A Disruptive Approach for Liver Cancer |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2022 - 2025 |
| Title: | Elucidating the role of tumor-propagating cells in the response of colorectal cancer to MAPK-targeting therapy |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2022 - 2025 |
| Title: | Therapeutic approaches for TGF-beta-enriched minimal residual disease in patients with colorectal cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP220416 |
| Date: | 2022 - 2025 |
| Title: | Histone Modifiers and Enhancer Reprogramming in Prostate Cancer Metastasis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Date: | 2021 - 2026 |
| Title: | Fgl2 neutralizing therapy for inducing tumor specific brain resident immune memory against CNS tumor relapse |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01NS122857-01 |
| Date: | 2021 - 2022 |
| Title: | Multi-modal imaging to characterize the spatiotemporal evolution of thermochemical ablation |
| Funding Source: | SIR FOUNDATION |
| Role: | Co-I |
| Date: | 2020 - 2022 |
| Title: | Interactions of Menopausal Status, Adiposity and KRAS Mutation on Colorectal Cancer Biology |
| Funding Source: | Department of Defense (DOD) |
| Role: | Collaborator |
| Date: | 2020 - 2025 |
| Title: | Use of Autologous Humanized Mouse Models to Model Immunotherapy in PIK3CA Colorectal Cancer Patient Derived Xenografts |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Date: | 2020 - 2023 |
| Title: | Adiposity and Colorectal Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Date: | 2019 - 2024 |
| Title: | Cancer Center Support (CORE) Grant |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2019 - 2022 |
| Title: | Tailoring CAR-based Immunotherapy Strategies to T Cell Lymphoma |
| Funding Source: | BCM/Stand Up to Cancer (SU2C) |
| Role: | Co-I |
| Title: | Humanized patient-derived xenografts: a co-clinical trial for MSS, BRAF V600E CRC |
| Funding Source: | MD Anderson SPORE in Gastrointestinal Cancer |
| Role: | Pathologist |
| Title: | IL-1-p62 Axis Regulation and Function in Castration Resistant PCa |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Collaborator |
| Title: | IL-1-p62 Axis Regulation and Function in Castration Resistant PCa |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Title: | Interleukin-1 Drives p62-Dependent androgen receptor independence in treatment resistant prostate cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Collaborator |
Patient Reviews
CV information above last modified April 02, 2025