Natalie Wall Fowlkes, D.V.M., Ph.D., DACVP, DABT
Department of Veterinary Medicine and Surgery, Division of VP, Research
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Veterinary Medicine and Surgery, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2018 | Louisiana State University, Baton Rouge, LA, USA, PHD, Veterinary and Biomedical Sciences |
| 2010 | Louisiana State University, Baton Rouge, LA, USA, DVM, Veterinary Medicine |
| 2006 | Louisiana State University, Baton Rouge, LA, USA, BS, Animal Science |
Postgraduate Training
| 2015-2018 | Research Fellowship, Postdoctoral Fellowship in Experimental Medicine and Pathology (NIH T32), Louisiana State University School of Veterinary Medicine, Baton Rouge, LA |
| 2010-2013 | Clinical Residency, Anatomic Pathology, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA |
Board Certifications
| 2016 | American College of Veterinary Pathologists |
Experience & Service
Administrative Appointments/Responsibilities
Director, DISCOVER Summer Research Program, Department of Veterinary Medicine and Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Education Director (Department level), Department of Veterinary Medicine and Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Other Appointments/Responsibilities
Associate Member, MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2021 - Present
Institutional Committee Activities
Member, Faculty Senate Education Committee, 2021 - Present
Senator, Faculty Senate, 2020 - Present
Honors & Awards
| 2017 | ACVP Young Investigator Award (Experimental Disease Division), American College of Veterinary Pathology |
| 2013 | Veterinary Pathology Scholarship Award, Charles Louis Davis, DVM Foundation for the Advancement of Veterinary and Comparative Pathology |
| 2010 | Bayer Excellence in Communication Award, LSU School of Veterinary Medicine |
| 2010 | Oncology Certificate of Excellence Award, LSU School of Veterinary Medicine |
| 2009 | LSU SCAVMA Bookstore Scholarship, LSU School of Veterinary Medicine |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Pollard AC, Paolillo V, Radaram B, Qureshy S, Li L, Maity T, Wang L, Uddin MN, Wood CG, Karam JA, Pagel MD, Piwnica-Worms D, Millward SW, Fowlkes NW, Norton W, Engel BJ, Pisaneschi F, Zacharias NM. PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine. Mol Imaging Biol 24(6):959-972, 2022. e-Pub 2022. PMID: 35732988.
- More A, Ito I, Haridas V, Chowdhury S, Gu Y, Dickson P, Fowlkes N, Shen JP. Oncogene addiction to GNAS in GNASR201 mutant tumors. Oncogene 41(35):4159-4168, 2022. e-Pub 2022. PMID: 35879396.
- Pant V, Aryal NK, Xiong S, Chau GP, Fowlkes NW, Lozano G. Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo. Cancer Res 82(7):1313-1320, 2022. PMID: 35078816.
- Damasco JA, Huang SY, Perez JVD, Manongdo JAT, Dixon KA, Williams ML, Jacobsen MC, Barbosa R, Canlas GM, Chintalapani G, Melancon AD, Layman RR, Fowlkes NW, Whitley EM, Melancon MP. Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs. ACS Biomater Sci Eng 8(4):1676-1685, 2022. e-Pub 2022. PMID: 35343679.
- Delahoussaye AM, Abi Jaoude J, Green M, Fujimoto TN, Molkentine J, Garcia Garcia CJ, Gay JP, Feng N, Marszalek J, Fowlkes N, Taniguchi CM. Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model. BMC Cancer 22(1):174, 2022. e-Pub 2022. PMID: 35172762.
- Kanikarla Marie P, Sorokin AV, Bitner LA, Aden R, Lam M, Manyam G, Woods MN, Anderson A, Capasso A, Fowlkes N, Overman MJ, Menter DG, Kopetz S. Autologous humanized mouse models to study combination and single-agent immunotherapy for colorectal cancer patient-derived xenografts. Front Oncol 12:994333, 2022. e-Pub 2022. PMID: 36212401.
- Sen A, Fowlkes NW, Kingsley CV, Kulp AM, Huynh T, Willis BJ, Brewer Savannah KJ, Bordes MCA, Hwang KP, McCulloch MM, Stafford RJ, Contreras A, Reece G, Brock KK. Technical note: Histological validation of anatomical imaging for breast modeling using a novel cryo-microtome. Med Phys 48(11):7323-7332, 2021. e-Pub 2021. PMID: 34559413.
- Park J, Tacam MJ, Chauhan G, Cohen EN, Gagliardi M, Iles LR, Ueno NT, Battula VL, Sohn YK, Wang X, Kim HS, Krishnamurthy S, Fowlkes NW, Green MM, Bartholomeusz GA, Tripathy D, Reuben JM, Bartholomeusz C. Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression. Breast Cancer Res Treat 189(2):333-345, 2021. e-Pub 2021. PMID: 34241740.
- Aslan B, Kismali G, Chen LS, Iles LR, Mahendra M, Peoples M, Gagea M, Fowlkes NW, Zheng X, Wang J, Vellano CP, Marszalek JR, Bertilaccio MTS, Gandhi V. Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL. Blood Adv 5(16):3134-3146, 2021. PMID: 34424317.
- Kerbauy LN, Marin ND, Kaplan M, Banerjee PP, Berrien-Elliott MM, Becker-Hapak M, Basar R, Foster M, Garcia Melo L, Neal CC, McClain E, Daher M, Nunez Cortes AK, Desai S, Inng Lim FW, Mendt MC, Schappe T, Li L, Shaim H, Shanley M, Ensley EL, Uprety N, Wong P, Liu E, Ang SO, Cai R, Nandivada V, Mohanty V, Miao Q, Shen Y, Baran N, Fowlkes NW, Chen K, Muniz-Feliciano L, Champlin RE, Nieto YL, Koch J, Treder M, Fischer W, Okamoto OK, Shpall EJ, Fehniger TA, Rezvani K. Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies. Clin Cancer Res 27(13):3744-3756, 2021. e-Pub 2021. PMID: 33986022.
- Shaim H, Shanley M, Basar R, Daher M, Gumin J, Zamler DB, Uprety N, Wang F, Huang Y, Gabrusiewicz K, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Mendt M, Li S, Lu J, Wei J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Kassab C, Li L, Ozcan G, Banerjee PP, Shen Y, Gilbert AL, Jones CM, Bdiwi M, Nunez-Cortes AK, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Li Y, Hu J, Draetta G, Marin D, Yu D, Mielke S, Eyrich M, Champlin RE, Chen K, Lang FF, Shpall EJ, Heimberger AB, Rezvani K. Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest 131(14), 2021. PMID: 34138753.
- Wu M, Xia X, Hu J, Fowlkes NW, Li S. WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression. Nat Commun 12(1):3500, 2021. e-Pub 2021. PMID: 34108491.
- Lulla AR, Akli S, Karakas C, Ha MJ, Fowlkes NW, Mitani Y, Bui T, Wang J, Rao X, Hunt KK, Meijer L, El-Naggar AK, Keyomarsi K. LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers. Oncogenesis 10(5):40, 2021. e-Pub 2021. PMID: 33990543.
- Konen JM, Rodriguez BL, Padhye A, Ochieng JK, Gibson L, Diao L, Fowlkes NW, Fradette JJ, Peng DH, Cardnell RJ, Kovacs JJ, Wang J, Byers LA, Gibbons DL. Dual inhibition of MEK and AXL targets tumor cell heterogeneity and prevents resistant outgrowth mediated by the epithelial-to-mesenchymal transition in NSCLC. Cancer Res 81(5):1398-1412, 2021. e-Pub 2021. PMID: 33402388.
- Daher M, Basar R, Gokdemir E, Baran N, Uprety N, Nunez Cortes AK, Mendt M, Kerbauy LN, Banerjee PP, Shanley M, Imahashi N, Li L, Lim FLWI, Fathi M, Rezvan A, Mohanty V, Shen Y, Shaim H, Lu J, Ozcan G, Ensley E, Kaplan M, Nandivada V, Bdiwi M, Acharya S, Xi Y, Wan X, Mak D, Liu E, Jiang XR, Ang S, Muniz-Feliciano L, Li Y, Wang J, Kordasti S, Petrov N, Varadarajan N, Marin D, Brunetti L, Skinner RJ, Lyu S, Silva L, Turk R, Schubert MS, Rettig GR, McNeill MS, Kurgan G, Behlke MA, Li H, Fowlkes NW, Chen K, Konopleva M, Champlin RE, Shpall EJ, Rezvani K. Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. Blood 137(5):624-636, 2021. e-Pub 2020. PMID: 32902645.
- Janke LJ, Imai DM, Tillman H, Doty R, Hoenerhoff MJ, Xu JJ, Freeman ZT, Allen P, Fowlkes NW, Iacobucci I, Dickerson K, Mullighan CG, Vogel P, Rehg JE. Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts. Vet Pathol 58(1):300985820970144, 2021. e-Pub 2020. PMID: 33208054.
- Uche IK, Fowlkes NW, Vu L, Watanabe T, Carossino M, Nabi R, Del Piero F, Rudd JS, Kousoulas KG, Rider PJF. The Novel Oncolytic Herpes Simplex Virus Type-1 (HSV-1) VC2 Promotes Long-lasting, Systemic Anti-melanoma Tumor Immune Responses and Increased Survival in an Immunocompetent B16F10-derived Mouse Melanoma Model. J Virol 95(3), 2021. e-Pub 2021. PMID: 33177208.
- Mendt M, Daher M, Basar R, Shanley M, Kumar B, Wei Inng FL, Acharya S, Shaim H, Fowlkes NW, Tran JP, Gokdemir E, Uprety N, Nunez-Cortes AK, Ensley E, Mai T, Kerbauy LN, Melo-Garcia L, Lin P, Shen Y, Mohanty V, Lu J, Li S, Nandivada V, Wang J, Banerjee P, Reyes-Silva F, Liu E, Ang S, Gilbert A, Li Y, Wan X, Gu J, Zhao M, Baran N, Muniz-Feliciano L, Wilson J, Kaur I, Gagea M, Konopleva M, Marin D, Tang G, Chen K, Champlin R, Rezvani K, Shpall EJ. Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD. Front Immunol 12:631353, 2021. e-Pub 2021. PMID: 34017325.
- Kanikarla Marie P, Fowlkes NW, Afshar-Kharghan V, Martch SL, Sorokin A, Shen JP, Morris VK, Dasari A, You N, Sood AK, Overman MJ, Kopetz S, Menter DG. The Provocative Roles of Platelets in Liver Disease and Cancer. Front Oncol 11:643815, 2021. e-Pub 2021. PMID: 34367949.
- Moyer SM, Wasylishen AR, Qi Y, Fowlkes N, Su X, Lozano G. p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo. Proc Natl Acad Sci U S A 117(38):23663-23673, 2020. e-Pub 2020. PMID: 32900967.
- Basar R, Daher M, Uprety N, Gokdemir E, Alsuliman A, Ensley E, Ozcan G, Mendt M, Hernandez Sanabria M, Kerbauy LN, Nunez Cortes AK, Li L, Banerjee PP, Muniz-Feliciano L, Acharya S, Fowlkes N, Lu J, Li S, Mielke S, Kaplan M, Nandivada V, Bdaiwi M, Kontoyiannis AD, Li Y, Liu E, Ang S, Marin D, Brunetti L, Gundry MC, Turk R, Schubert MS, Rettig GR, McNeill MS, Kurgan G, Behlke MA, Champlin R, Shpall EJ, Rezvani K. Large-scale GMP-compliant CRISPR-Cas9-mediated deletion of the glucocorticoid receptor in multivirus-specific T cells. Blood Adv 4(14):3357-3367, 2020. PMID: 32717029.
- Casal RF, Schwalk AJ, Fowlkes N, Aburto RR, Norton W, Dixon KA, Lin S, Shaitelman SF, Chintalapani G, Hill L. Endobronchial ultrasound-guided injection of NBTXR3 radio enhancing nanoparticles into mediastinal and hilar lymph nodes: a swine model to evaluate feasibility, injection technique, safety, nanoparticle retention and dispersion. J Thorac Dis 12(5):2317-2324, 2020. PMID: 32642136.
- Fowlkes N, Clemons K, Rider PJ, Subramanian R, Wakamatsu N, Langohr I, Kousoulas KG. Factors Affecting Growth Kinetics and Spontaneous Metastasis in the B16F10 Syngeneic Murine Melanoma Model. Comp Med 69(1):1-7, 2019. e-Pub 2018. PMID: 30563585.
- Leissinger MK, McCauley C, Fowlkes N, Grasperge BJ. What is your diagnosis? Nasal lesion in a horse. Vet Clin Pathol 46(2):361-362, 2017. e-Pub 2017. PMID: 28249099.
- Le Donne V, Crossland N, Brandão J, Sokolova Y, Fowlkes N, Nevarez JG, Langohr IM, Gaunt SD. Nannizziopsis guarroi infection in 2 Inland Bearded Dragons (Pogona vitticeps): clinical, cytologic, histologic, and ultrastructural aspects. Vet Clin Pathol 45(2):368-375, 2016. e-Pub 2016. PMID: 27010762.
- Evans D, Fowlkes N. Renal leiomyosarcoma in a cat. J Vet Diagn Invest 28(3):315-8, 2016. e-Pub 2016. PMID: 26975352.
- Sumner JP, Pucheu-Haston CM, Fowlkes N, Merchant S. Dorsal skin necrosis secondary to a solar-induced thermal burn in a brown-coated dachshund. Can Vet J 57(3):305-8, 2016. PMID: 26933270.
- Leissinger MK, Garber JB, Fowlkes N, Grooters AM, Royal AB, Gaunt SD. Mycobacterium fortuitum lipoid pneumonia in a dog. Vet Pathol 52(2):356-9, 2015. e-Pub 2014. PMID: 24788402.
- Doss GA, Nevarez JG, Fowlkes N, da Cunha AF. Evaluation of metomidate hydrochloride as an anesthetic in leopard frogs (Rana pipiens). J Zoo Wildl Med 45(1):53-9, 2014. PMID: 24712162.
- Brandão J, Woods S, Fowlkes N, Leissinger M, Blair R, Pucheu-Haston C, Johnson J, Elster Phillips C, Tully T. Disseminated histoplasmosis (Histoplasma capsulatum) in a pet rabbit: case report and review of the literature. J Vet Diagn Invest 26(1):158-62, 2014. e-Pub 2014. PMID: 24452788.
- Gupta A, Garber J, Fowlkes N, Rademacher N, Shiomitsu K, Evans DE, Gaunt SD. What is your diagnosis? Abdominal fluid from a dog. Vet Clin Pathol 42(1):113-4, 2013. e-Pub 2012. PMID: 23083469.
- Gumber S, Fowlkes N, Cho DY. Disseminated sclerosing peritoneal mesothelioma in a dog. J Vet Diagn Invest 23(5):1046-50, 2011. PMID: 21908373.
- Scollard DM, Chaduvula MV, Martinez A, Fowlkes N, Nath I, Stryjewska BM, Kearney MT, Williams DL. Increased CXC ligand 10 levels and gene expression in type 1 leprosy reactions. Clin Vaccine Immunol 18(6):947-53, 2011. e-Pub 2011. PMID: 21508169.
Abstracts
- Hu JM, Zhang WD, Xia XQ, Yang Q, Chen YH, Fowlkes N, Livingston JA, Zhang ZT, Mahadeo KM, Gill JB, Dotti G, Kopetz S, Gorlick R, Li SL. CRS free T cell therapy: T cell membrane anchored and tumor targeted IL12 (ATTIL12)-T cell therapy eliminates large tumors, overcomes heterogeneity, and avoids adverse effects. Journal of Immunology 204(1), 2020. e-Pub 2020.
- Fowlkes NW, Swain J, Gagea M, Lockworth C, Tinkey P, Jensen V, Whitley EM. Cutaneous and Gastrointestinal Dysbiosis in Immunodeficient Mice. FASEB Journal 33(1S), 2019. e-Pub 2019.
- Fowlkes NW, Whitley E, Gagea M, Swain J, Lockworth C, Ueno N, Jensen V. Macrophage Activation Syndrome in Humanized NOD.CGPRKDCSIDIL2RGTM1WJL/SZJ (NSG) Expressing Human Cytokines IL-3, GM-CSF, and SCF (NSG-SGM3) After Engraftment with Human CD34+ Hematopoietic Stem Cells:130, 2019.
Grant & Contract Support
| Title: | Fgl2 neutralizing therapy for inducing tumor specific brain resident immune memory against CNS tumor relapse |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Multi-modal imaging to characterize the spatiotemporal evolution of thermochemical ablation |
| Funding Source: | SIR FOUNDATION |
| Role: | Co-Investigator |
| Title: | Characterization of endovascular ablative therapies with computational modeling |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Biodegradable Radiopaque Polymeric Scaffolds Loaded with Mesenchymal Stem Cells for Image-Guided Arteriovenous Fistula Maturation and Long-Term Patency |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Therapeutic approaches for TGF-beta-enriched minimal residual disease in patients with colorectal cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Title: | The Role of MELK in Stromal Reorganization of Aggressive Breast Cancers |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-Investigator |
| Title: | Heterozygous KMT2D Loss and Medulloblastoma |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | The Role of HIF2 in Pancreatic Ductal Adenocarcinoma |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Cis-aconitate decarboxylase (ACOD1) in PMN-MDSC and prostate cancer progression |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |