Neeta Somaiah, MD

Peer-Reviewed Articles

1. Van Tine BA, Govindarajan R, Attia S, Somaiah N, Barker SS, Shahir A, Barrett E, Lee P, Wacheck V, Ramage SC, Tap WD. Incidence and Management of Olaratumab Infusion-Related Reactions. J Oncol Pract 15(11):e925-e933, 2019. e-Pub 2019. PMID: 31268811.
2. Somaiah N, Block MS, Kim JW, Shapiro GI, Do KT, Hwu P, Eder JP, Jones RL, Lu H, Ter Meulen JH, Bohac C, Chen M, Hsu FJ, Gnjatic S, Pollack SM. First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1. Clin Cancer Res 25(19):5808-5817, 2019. e-Pub 2019. PMID: 31227504.
3. Chrisinger JSA, Al-Zaid T, Keung EZ, Leung C, Lin HY, Roland CL, Torres KE, Benjamin RS, Ingram DR, Khan S, Somaiah N, Amini B, Feig BW, Lazar AJ, Wang WL. The degree of sclerosis is associated with prognosis in well-differentiated liposarcoma of the retroperitoneum. J Surg Oncol 120(3):382-388, 2019. e-Pub 2019. PMID: 31206726.
4. Subbiah V, Anderson PM, Kairemo K, Hess K, Huh WW, Ravi V, Daw NC, Somaiah N, Ludwig JA, Benjamin RS, Chawla S, Hong DS, Meric-Bernstam F, Ravizzini G, Kleinerman E, Macapinlac H, Rohren E. Alpha particle Radium 223 dichloride in high-risk osteosarcoma: a phase I dose escalation trial. Clin Cancer Res 25(13):3802-3810, 2019. e-Pub 2019. PMID: 30733229.
5. Conley AP, Wang WL, Livingston JA, Ravi V, Tsai JW, Ali A, Ingram DR, Lowery CD, Roland CL, Somaiah N, Hwu P, Yee C, Subbiah V, Futreal A, Lazar AJ, Patel S, Roszik J. MAGE-A3 is a Clinically Relevant Target in Undifferentiated Pleomorphic Sarcoma/Myxofibrosarcoma. Cancers (Basel) 11(5), 2019. e-Pub 2019. PMID: 31096717.
6. Keung Z, Somaiah N. Overview of liposarcomas and their genomic landscape. J Transl Genet Genom, 2019.
7. Wilkins A, Melcher A, Somaiah N. Science in Focus: Biological Optimisation of Radiotherapy Fraction Size in an Era of Immune Oncology. Clin Oncol (R Coll Radiol) 30(10):605-608, 2018. e-Pub 2018. PMID: 30041845.
8. Somaiah N, Beird HC, Barbo A, Song J, Mills Shaw KR, Wang WL, Eterovic K, Chen K, Lazar A, Conley AP, Ravi V, Hwu P, Futreal A, Simon G, Meric-Bernstam F, Hong D. Targeted next generation sequencing of well-differentiated/dedifferentiated liposarcoma reveals novel gene amplifications and mutations. Oncotarget 9(28):19891-19899, 2018. e-Pub 2018. PMID: 29731991.
9. Beird HC, Wu CC, Ingram DR, Wang WL, Alimohamed A, Gumbs C, Little L, Song X, Feig BW, Roland CL, Zhang J, Benjamin RS, Hwu P, Lazar AJ, Futreal PA, Somaiah N. Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. Cold Spring Harb Mol Case Stud 4(2), 2018. e-Pub 2018. PMID: 29610390.
10. Zobniw CM, Trinh VA, Posey K, Somaiah N. Olaratumab in the management of advanced soft tissue sarcoma. J Oncol Pharm Pract((2)):442-448, 2018.
11. Goumard C, Marcal LP, Wang WL, Somaiah N, Okuno M, Roland CL, Tzeng CD, Chun YS, Feig BW, Vauthey JN, Conrad C. Long-Term Survival According to Histology and Radiologic Response to Preoperative Chemotherapy in 126 Patients Undergoing Resection of Non-GIST Sarcoma Liver Metastases. Ann Surg Oncol 25(1):107-116, 2018. e-Pub 2017. PMID: 29116489.
12. Keung EZ, Tsai JW, Ali AM, Cormier JN, Bishop AJ, Guadagnolo BA, Torres KE, Somaiah N, Hunt KK, Wargo JA, Lazar AJ, Wang WL, Roland CL. Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: Rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy. Oncoimmunology 7(2):e1385689, 2018. e-Pub 2017. PMID: 29308306.
13. Stacchiotti S, Mir O, Le Cesne A, Vincenzi B, Fedenko A, Maki RG, Somaiah N, Patel S, Brahmi M, Blay JY, Boye K, Sundby Hall K, Gelderblom H, Hindi N, Martin-Broto J, Kosela H, Rutkowski P, Italiano A, Duffaud F, Kobayashi E, Casali PG, Provenzano S, Kawai A. Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma. Oncologist 23(1):62-70, 2018. e-Pub 2017. PMID: 28754721.
14. Li H, Meng QH, Noh H, Somaiah N, Torres KE, Xia X, Batth IS, Joseph CP, Liu M, Wang R, Li S. Cell-surface vimentin-positive macrophage-like circulating tumor cells as a novel biomarker of metastatic gastrointestinal stromal tumors. Oncoimmunology 7(5):e1420450, 2018. e-Pub 2018. PMID: 29721368.
15. Samuels BL, Chawla SP, Somaiah N, Staddon AP, Skubitz KM, Milhem MM, Kaiser PE, Portnoy DC, Priebat DA, Walker MS, Stepanski EJ. Results of a prospective phase 2 study of pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma. Cancer 123(23):4640-4647, 2017. e-Pub 2017. PMID: 28832986.
16. Groisberg R, Hong DS, Behrang A, Hess K, Janku F, Piha-Paul S, Naing A, Fu S, Benjamin R, Patel S, Somaiah N, Conley A, Meric-Bernstam F, Subbiah V. Characteristics and outcomes of patients with advanced sarcoma enrolled in early phase immunotherapy trials. J Immunother Cancer 5(1):100, 2017. e-Pub 2017. PMID: 29254498.
17. Farag S, Somaiah N, Choi H, Heeres B, Wang WL, van Boven H, Nederlof P, Benjamin R, van der Graaf W, Grunhagen D, Boonstra PA, Reyners AK, Gelderblom H, Steeghs N. Clinical characteristics and treatment outcome in a large multicentre observational cohort of PDGFRA exon 18 mutated gastrointestinal stromal tumour patients. Eur J Cancer 76:76-83, 2017. e-Pub 2017. PMID: 28284172.
18. Tseng WW, Somaiah N, Engleman EG. Potential for immunotherapy in soft tissue sarcoma. Hum Vaccun Immunother 10(11):3117-24, 2014. PMID: 25412843.
19. Somaiah N, Fidler MJ, Garrett-Mayer E, Wahlquist A, Shirai K, Buckingham L, Hensing T, Bonomi P, Simon GR. Epidermal growth factor (EGFR) mutations are exceptionally rare in thyroid tanscription factor (ITTF-1)-negative adenocarcinomas of the lung. Oncoscience, 2014.
20. Burgoyne AM, Somaiah N, Sicklick JK. Gastrointestinal stromal tumors in the setting of multiple tumor syndromes. Curr Opin Oncol 26(4):408-14, 2014. PMID: 24840526.
21. Somaiah N, Fidler MJ, Garrett-Mayer E, Wahlquist A, Shirai K, Buckingham L, Hensing T, Bonomi P, Simon GR. Epidermal growth factor receptor (EGFR) mutations are exceptionally rare in thyroid transcription factor (TTF-1)-negative adenocarcinomas of the lung. Oncoscience 1(8):522-528, 2014. e-Pub 2014. PMID: 25594059.
22. Somaiah N. The Role of Combination Chemotherapy in GIST. GIST Cancer Journal, 2014.
23. Tseng WW, Somaiah N, Engleman EG. Potential for immunotherapy in soft tissue sarcoma. Hum Vaccin Immunother 10(11):3117-24, 2014. PMID: 25625925.
24. Cauchi C, Somaiah N, Engstrom PF, Litwin S, Lopez M, Lee J, Davey M, Bove B, von Mehren M. Evaluation of nilotinib in advanced GIST previously treated with imatinib and sunitinib. Cancer Chemother Pharmacol 69(4):977-82, 2012. e-Pub 2011. PMID: 22119758.
25. Aggarwal C, Somaiah N, Simon G. Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed?. Cancer Biol Ther 13(5):247-63, 2012. PMID: 22481432.
26. Somaiah N, von Mehren M. New drugs and combinations for the treatment of soft tissue sarcoma: A review. Cancer Manag Res 2012:4:397-411, 2012. e-Pub 2012. PMID: 23226072.
27. Somaiah N, Simon GR. Molecular targeted agents and biologic therapies for lung cancer. J Thorac Oncol 6(11 Suppl 4):S1758-85, 2011. PMID: 22005529.
28. Somaiah N, Simon GR. Molecular targeted agents and biologic therapies for non-small cell lung cancer. J Thorac Oncol 5(12 Suppl 6):S434-54, 2010. PMID: 21102235.
29. Aggarwal C, Somaiah N, Simon GR. Biomarkers with predictive and prognostic function in non-small cell lung cancer: ready for prime time?. J Natl Compr Canc Netw 8(7):822-32, 2010. PMID: 20679541.
30. Somaiah N, Simon GR. Molecular targeted therapy in non-small cell lung cancer: an overview of available agents. J Thorac Oncol 4(11 Suppl 3):S1046-56, 2009. PMID: 19861914.
31. Somaiah N, von Mehren M. New therapeutic approaches for advanced gastrointestinal stromal tumors. Hematol Oncol Clin North Am 23(1):139-50, x, 2009. PMID: 19248977.
32. Banumathy G, Somaiah N, Zhang R, Tang Y, Hoffmann J, Andrake M, Ceulemans H, Schultz D, Marmorstein R, Adams PD. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol 29(3):758-70, 2009. e-Pub 2008. PMID: 19029251.
33. Roland CL, Bednarski BK, Watson K, Torres KE, Cormier JN, Wang WL, Lazar AJ, Somaiah N, Hunt KK, Feig BW. Identification of preoperative factors associated with outcomes following surgical management of intra-abdominal recurrent or metastatic GIST following neoadjuvant tyrosine kinase inhibitor therapy. J Surg Oncol. e-Pub 2018. PMID: 29448300.
34. Ikoma N, Roland CL, Torres KE, Chiang YJ, Wang WL, Somaiah N, Mann GN, Hunt KK, Cormier JN, Feig BW. Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit. Ann Surg Oncol. e-Pub 2018. PMID: 29520652.
35. Ikoma N, Roland CL, Torres KE, Chiang YJ, Wang WL, Somaiah N, Mann GN, Hunt KK, Cormier JN, Feig BW. Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center. J Surg Oncol. e-Pub 2017. PMID: 29228466.

Manuals, Teaching Aids, Other Teaching Publications

1. Somaiah N. VEGF - Targeting in Gastrointestinal Stromal Tumors, 2017.

Other Articles

1. Neeta Somaiah, Hannah Beird, Kenna Shaw, Juhee Song, Andrea Barbo, Wei-Lien Wang, Anthony Conley, Vinod Ravi, Ken Chen, Katrina Eterovic, Alexander J. F. Lazar, Patrick Hwu, Andrew Futreal, Funda Meric-Bernstam, David S. Hong Targeted next generation sequencing in well-differentated/dedifferentiated liposarcoma (WD/DD LPS) reveals novel gene alterations. Oncotarget, 2017.
2. Quintana RA, Banchs J, Gupta R, Lin HY, Raj SD, Conley A, Ravi V, Araujo D, Benjamin RS, Patel S, Vadhan-Raj S, Somaiah N Early evidence of cardiotoxicity and tumor response in patients with sarcomas after high cumulative dose doxorubicin given as a continuous infusion. Sarcoma 2017:7495914, 2017. PMID: 29081684.

Abstracts

1. Attia S, Pollack S, Van Tine BA, Chawla S, Druta M, Burgess M, Bohac G, Somaiah N. Clinical outcomes from a retrospective registry of patients with locally advanced/metastatic synovial sarcoma and myxoid round cell liposarcoma. J Clin Oncol, ASCO Annual Meeting 2019(37), 2019.
2. von Mehren M, Litwin S, Vinod R, Schuetze S, Movva S, Agulnik M, Kraft A, Tetzlaff E, Somaiah N. Multicenter phase II trial of pazopanib (P) in patients with angiosarcoma (AS). J Clin Oncol, ASCO Annual Meeting 2019(37), 2019. e-Pub 2019.
3. Somaiah N, Van Tine BA, Goodwin-Hill E, Milhem M. Phase II trial of gemcitabine (G) with pazopanib (P) or gemcitabine with docetaxel (T) in advanced soft tissue sarcoma (STS). J Clin Oncol, ASCO Annual Meeting 2019(37), 2019.
4. Neeta Somaiah, Sant P. Chawla, Matthew Stephen Block, John Charles Morris, Khanh Tu Do, Joseph W. Kim, Mihaela Druta, Kamalesh Kumar Sankhala, Patrick Hwu, Sacha Gnjatic, Hailing Lu, Richard T. Kenney, Gerry C. Bohac, Seth Pollack. Immune response, safety, and survival impact from CMB305 in NY-ESO-1+ recurrent soft tissue sarcomas (STS). J Clin Oncol 35, 2017.

Book Chapters

1. Somaiah N, Gupta R, Patel S. Chapter on Gastrointestinal Stromal Tumors. In: Textbook of GI Oncology, 2017.
2. Somaiah N. Gastrointestinal Stromal Tumors: Clinical Care Options In Practice. In: Online book chapter, 2016.
3. Somaiah N. Gastrointestinal Stromal Tumors: Clinical Care Options In Practice. In: Online book chapter, 2014.
4. Somaiah N, Patel S. Soft Tissue Sarcoma. In: Cancer Consult: Expertise for Clinical Practice. John Wiley and Sons, 2014.
5. Somaiah N. Gastrointestinal Stromal Tumors: Clinical Care Options In Practice. In: Online book chapter, 2013.
6. Somaiah N. Gastrointestinal Stromal Tumors: Clinical Care Options In Practice. In: Online book chapter, 2012.
7. Somaiah N, von Mehren M. The Role of Tyrosine Kinase Inhibitors in the Treatment of Gastrointestinal Stromal Tumors. In: Medscape, 2008.