Meet Nitin Jain, M.D.

Nitin Jain, M.D.
Department of Leukemia, Division of Cancer Medicine
About Dr. Nitin Jain
Nitin Jain, M.D., is a Professor of Medicine in the Department of Leukemia at The University of Texas MD Anderson Cancer Center in Houston, Texas, USA. He earned his medical degree from the All India Institute of Medical Sciences (AIIMS), New Delhi, India in 2002. He completed Internal Medicine residency at the Medical College of Wisconsin, Milwaukee. He then completed clinical fellowship in Leukemia at MD Anderson followed by a Leukemia research fellowship at Memorial Sloan-Kettering Cancer Center. He then pursued fellowship in Hematology/Oncology at The University of Chicago. He joined as a faculty in the Department of Leukemia at MD Anderson in July 2012. Dr. Jain treats patients with acute and chronic leukemias with focus of patients with chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL). Dr. Jain's research interests focus on new drug development for patients with leukemia, especially CLL and ALL. Since 2021, he has also served as Director, Leukemia CAR-T Program within the Department of Leukemia, MD Anderson.
Dr. Jain is Principal Investigator of several investigator-initiated phase I-II clinical trials, including combination targeted therapies (ibrutinib and venetoclax) in CLL, checkpoint inhibitor in Richter transformation, JAK2 inhibitor ruxolitinib in Ph-like ALL, novel CD22 antibody drug conjugate in B-ALL, venetoclax + chemotherapy in B- and T-ALL, ponatinib in T-ALL, and off-the-self allogeneic CARTs in B-ALL. The trial combining ibrutinib and venetoclax was published in New England Journal of Medicine in 2019. He has published papers in prominent journals including NEJM, Lancet, JAMA Oncology, Journal of Clinical Oncology, Blood, Clinical Cancer Research, Cancer, Leukemia & Lymphoma, and others.
He has won many awards during his career including Sardari Lal Kalra Gold Medal in Microbiology from AIIMS and Merit Award from the American Society of Clinical Oncology (ASCO). He secured first rank at the national level in India in the medical school (AIIMS) entrance examination. He received High-Impact Clinical Research Support Award from MD Anderson Cancer Center in the year 2014 and 2016. He has served as faculty on American Society of Hematology CRTI workshop from 2017-2019. He is recipient of Sabin Family Foundation Award in 2018. In 2020, he received MD Anderson Faculty Scholar award. In 2021, he was appointed Director of the CAR T program for the Leukemia Department, MD Anderson. In 2022, he received Leukemia and Lymphoma Society (LLS) Scholar in Clinical Research award as well as LLS Translational Research Program (TRP) award.
Present Title & Affiliation
Primary Appointment
Professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
2002 | All India Institute of Medical Sciences (AIIMS), New Delhi, IN, MBBS in Medicine |
Postgraduate Training
2009-2012 | Clinical Fellowship, Hematology-Oncology, University of Chicago Medical Center, Chicago, Illinois |
2008-2009 | Clinical Fellowship, Leukemia, Memorial Sloan-Kettering Cancer Center, New York, New York |
2007-2008 | Clinical Fellowship, Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas |
2004-2007 | Clinical Residency, Internal Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin |
2003-2003 | House Officer, All India Institute of Medical Sciences (AIIMS), New Delhi |
2002-2002 | Clinical Internship, All India Institute of Medical Sciences (AIIMS), New Delhi |
Licenses & Certifications
2012 | Medical Oncology |
2012 | Hematology |
2012 | Texas Medical License |
2007 | Internal Medicine |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2023
Assistant Professor, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2018
Administrative Appointments/Responsibilities
Director, Leukemia CAR-T Program, Department of Leukemia, MD Anderson Cancer Center, 2021 - Present
Extramural Institutional Committee Activities
Member, Faculty Senate, The University of Texas MD Anderson Cancer Center, 2024 - Present
Co-Leader, CLL MoonShot, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2020 - Present
Member, Scientific Research Committee (SRC), Member, The University of Texas MD Anderson Cancer Center, 2016 - Present
Member, CARTOX, The University of Texas MD Anderson Cancer Center, 2016 - Present
Associate Member, Institutional Review Board, The University of Texas MD Anderson Cancer Center, 2014 - 2016
Editorial Activities
Editorial Board Member, Cancer, 2020
Editorial Board Member, Clinical Lymphoma Myeloma and Leukemia, 2017
Editorial Board Member, Blood Advances, 2016 - 2020
Series Editor, Chronic Lymphocytic Leukemia, Current Hematologic Malignancy Reports, 2015
Co-Editor, @Point of Care (CLL), 2015
Honors & Awards
2022 - Present | Leukemia and Lymphoma Society (LLS) Translational Research Program (TRP) Award |
2022 - Present | Leukemia and Lymphoma Society (LLS) Scholar in Clinical Research |
2020 | Faculty Scholar Award, MD Anderson Cancer Center |
2018 | Sabin Family Foundation Fellow, MD Anderson Cancer Center |
2017 | Faculty, Clinical Research Training Institute (CRTI), American Society of Hematology |
2016 | Outstanding Young Investigator in Hematology, Indo-American Cancer Association |
2014 | Clinical Research Training Institute (CRTI), American Society of Hematology |
2014 | High-Impact Clinical Research Support Program (HI-CRSP), MD Anderson Cancer Center |
2008 | Merit Award, American Society of Clinical Oncology |
2006 | First Place Team, Doctors' Dilemma Medical Quiz Competition, American College of Physicians (Wisconsin Chapter) |
2002 | Ranked Second Overall in the Graduating Medical School Class, All India Institute of Medical Sciences |
1999 | Sardari Lal Kalra Gold Medal in Microbiology, All India Institute of Medical Sciences |
1998 | Scholarship for Academic Excellence, All India Institute of Medical Sciences |
1997 | First Rank in the country (India) for Medical School Entrance Examination, All India Institute of Medical Sciences |
1997 | National Merit Scholarship, Government of India |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2017. Treatment of Relapsed CLL. Conference. Treatment of Relapsed CLL. Houston, TX, US.
- 2017. Firstline treatment of CLL. Conference. Firstline treatment of CLL. Houston, TX, US.
- 2016. PI3 Kinase Inhibitors in CLL. Conference. PI3 Kinase Inhibitors in CLL. Houston, TX, US.
- 2015. Checkpoint Inhibitors in CLL. Conference. Checkpoint Inhibitors in CLL. Houston, TX, US.
Regional Presentations
- 2018. CLL - Patient Education Program. Conference. CLL - Patient Education Program. San Antonio, TX, US.
- 2016. CLL - Patient Education Program. Conference. CLL - Patient Education Program. Omaha, NE, US.
- 2015. CLL - Patient Education Program. Conference. CLL - Patient Education Program. Omaha, NE, US.
National Presentations
- 2019. ASH Updates in CLL. Conference. Banner MD Anderson. Phoenix, AZ, US.
- 2019. Official ASH Updates in CLL (North America). Conference. American Society of Hematology, US.
- 2018. Frontline therapy of CLL (Education Session). Conference. American Society of Hematology. San Diego, CA, US.
- 2018. Updates in Acute Lymphoblastic Leukemia. Conference. Updates in Acute Lymphoblastic Leukemia. Maui, HI, US.
- 2017. CLL State of the Art Update. Conference. CLL State of the Art Update. Houston, TX, US.
- 2017. Oral Abstract Discussion (CLL). Conference. Oral Abstract Discussion (CLL). Chicago, IL, US.
- 2017. Novel Combination Strategies in CLL. Conference. Novel Combination Strategies in CLL. Washington DC, DC, US.
- 2017. Relapsed/Refractory CLL and MRD. Conference. Physicians Education Resource. Miami, FL, US.
- 2017. Genomics and expression profile of ALL: Utility in guiding therapy. Conference. Oncology Meeting Innovations. Dallas, TX, US.
- 2016. ALL 2016. MDACC Experience: HCVAD and Beyond. Conference. Society for Adolescent and Young Adult Oncology (SAYAO). Irvine, CA, US.
- 2016. Defining The Immune Checkpoint Landscape in Leukemias: Clinicopathologic Correlations. Conference. Defining The Immune Checkpoint Landscape in Leukemias: Clinicopathologic Correlations. Houston, TX, US.
- 2016. New Monoclonal And Checkpoint Inhibitors in CLL. Conference. New Monoclonal And Checkpoint Inhibitors in CLL. Houston, TX, US.
- 2016. Advances and Treatments in Chronic Lymphocytic Leukemia (CLL). Conference. Medical Oncology and Hematology 2016. Houston, TX, US.
- 2015. Prevalence and Economic Burden of CLL in the Era of Oral Targeted Therapies. Conference. American Society of Hematology. Orlando, FL, US.
- 2015. Current Trends in treatment for B-cell. Conference. Auven Therapeutics. Philadelphia, PA, US.
- 2015. New immune therapy for CLL. Conference. CTRC, Health Science Center, San Antonio. San Antonio, TX, US.
- 2015. Targeted Therapy in CLL. Conference. University of Nebraska Medical Center. Omaha, NE, US.
- 2015. Checkpoint Inhibitors: Why Should They Work in CLL?. Conference. Checkpoint Inhibitors: Why Should They Work in CLL?. Houston, TX, US.
- 2014. PI3K Inhibition (Idelalisib) in CLL. Conference. Chemotherapy Foundation Symposium. New York, NY, US.
- 2014. Richter Syndrome: From Biology to Treatment. Conference. SOHO Annual Meeting. Houston, TX, US.
International Presentations
- 2019. Official ASH Updates in CLL. Conference. American Society of Hematology. Lima, PE.
- 2019. Official ASH Updates in CLL (Mediterranean). Conference. American Society of Hematology. Athens, GR.
- 2019. ASH Updates in CLL. Conference. CCOLD Meeting. Banff, CA.
- 2019. ASH Updates in CLL. Conference. American Society of Hematology. New Delhi, IN.
- 2017. CLL: State of the Art Update. Conference. CLL: State of the Art Update. Guwahati, IN.
- 2017. Making sense of Chronic Lymphocytic Leukemia management. Conference. Making sense of Chronic Lymphocytic Leukemia management. Abu Dhabi, AE.
- 2017. Immune Therapy of ALL. Conference. Immune Therapy of ALL. Guwahati, IN.
- 2017. New Developments in Richter Syndrome (Hematology-in-focus session). Conference. New Developments in Richter Syndrome (Hematology-in-focus session). Madrid, ES.
- 2017. ALL 2017. MDACC Experience: HCVAD and Beyond. Conference. Pan Arab Hematology Congress. Kuwait, KW.
- 2017. CLL 2017. Conference. Pan Arab Hematology Congress. Kuwait, KW.
- 2017. Immunotherapy in ALL. Conference. Pan Arab Hematology Congress. Kuwait, KW.
- 2015. Prevalence and Economic Burden of CLL in the Era of Oral Targeted Therapies. Conference. IWCLL. Sydney, AU.
- 2014. Update on Chronic Lymphocytic Leukemia. Conference. Apollo Cancer Conclave. Chennai, IN.
- 2014. CML - First line options. Conference. Apollo Cancer Conclave. Chennai, IN.
- 2014. Therapeutic Advances in Chronic Lymphocytic Leukemia. Conference. MDACC and Delhi Cancer Institute. New Delhi, IN.
- 2013. New Agents in Chronic Lymphocytic Leukemia (CLL). Conference. Hematology Mexico Society. Mazatlan, MX.
Formal Peers
- 2017. State of the Art CLL. Invited. New Delhi, IN.
- 2016. How we treat acute lymphoblastic leukemia 2016. Invited. New Delhi, IN.
- 2016. How we treat acute lymphoblastic leukemia 2016. Invited. Chandigarh, IN.
- 2016. ASH 2015 Update in CLL. Invited. Omaha, NE, US.
- 2016. Chronic Lymphocytic Leukemia: State of the Art in 2016 and Beyond. Invited. Dallas, TX, US.
- 2015. ASH 2014 Update in CLL. Invited. Omaha, NE, US.
Grant & Contract Support
Date: | 2026 - 2026 |
Title: | Integrated Multi-Omics Profiling of Measurable Residual Disease Reveals Molecular Drivers and Therapeutic Resistance in CLL |
Funding Source: | CLL Global |
Role: | PI |
Date: | 2023 - Present |
Title: | 2022-0531: A phase 2, open-label, multicenter, basket study evaluating the safety and efficacy of Brexucabtagene autoleucel in adults with rare B-cell Malignancies (ZUMA-25) |
Funding Source: | Kite Pharma, Inc |
Role: | PI |
Date: | 2022 - 2025 |
Title: | LCK-targeted Therapy in T cell Acute Lymphoblastic Leukemia |
Funding Source: | Leukemia and Lymphoma Society |
Role: | PI |
ID: | 6665-23 |
Date: | 2022 - 2027 |
Title: | Combination Targeted Therapy in Chronic Lymphocytic Leukemia |
Funding Source: | Leukemia and Lymphoma Society |
Role: | PI |
ID: | 2341-23 |
Date: | 2022 - 2027 |
Title: | Combination Targeted Therapy in Chronic Lymphocytic Leukemia |
Funding Source: | Leukemia & Lymphoma Society |
Role: | PI |
Date: | 2022 - 2025 |
Title: | 2021-0802 -- A Phase II Study of the Combination of Ponatinib with Mini-hyper CVD Chemotherapy and Venetoclax in Patients with Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia |
Funding Source: | Leukemia & Lymphoma Society and Takeda |
Role: | PI |
ID: | 00013912 |
Date: | 2021 - 2024 |
Title: | 2021-0272 - A Phase I/II Dose-Escalation and Expansion Study of the Selective PKC-β Inhibitor MS-553 in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma |
Funding Source: | MingSight Pharmaceuticals, Inc |
Role: | PI |
Date: | 2021 - 2024 |
Title: | 2020-0571 -- Ipilimumab Combined with Ibrutinib and Nivolumab for Patients with Chronic Lymphocytic Leukemia (CLL) and Richter Transformation (RT) |
Funding Source: | Bristol-Myers Squibb |
Role: | PI |
Date: | 2020 - 2028 |
Title: | 2020-0775 -- A Phase I Study of FT819 in Subjects with B-cell Malignancies |
Funding Source: | Fate Therapeutics, Inc |
Role: | PI |
Date: | 2020 - 2027 |
Title: | Protocol 2020-0411 -- Phase 1 and Dose Expansion Study of APR-246 in Combination with Ibrutinib or Venetoclax-based therapy in Subjects with TP53-Mutant Relapsed and/or Refractory Non-Hodgkin Lymphomas (NHL) including Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma |
Funding Source: | Aprea |
Role: | PI |
Date: | 2020 - 2027 |
Title: | Protocol 2019-0559 -- Long-term follow up of subjects who received PBCAR0191 in other clinical studies |
Funding Source: | Precision BioSciences, Inc |
Role: | PI |
Date: | 2019 - 2026 |
Title: | 2019-0218 -- A Phase 1/2a, Open-label, Dose-escalation, Dose-expansion, Parallel Assignment Study to Evaluate the Safety and Clinical Activity of PBCAR0191 in Subjects with Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL) |
Funding Source: | Precision BioSciences |
Role: | PI |
ID: | 2019-0218 |
Date: | 2019 - 2024 |
Title: | Targeting mitochondrial complex I in acute lymphoblastic leukemia |
Funding Source: | NIH/NCI |
Role: | Co-PI |
ID: | R01CA231364 (Konopleva) |
Date: | 2018 - 2022 |
Title: | Combined BTK and BCL2 Inhibition in CLL: A Non-Chemotherapy Therapeutic Approach |
Funding Source: | Leukemia and Lymphoma Society |
Role: | PI |
Date: | 2018 - 2025 |
Title: | 2017-1003: Phase I, open label dose-escalation and dose-expansion study to evaluate the safety, expansion, persistence and clinical activity of UCART22 (allogeneic engineered T-cells expressing anti-CD22 chimeric antigen receptor) in patients with relapsed or refractory CD22+B-cell acute lyphoblastic leukemia (B-ALL) |
Funding Source: | Cellectis |
Role: | PI |
Date: | 2018 - 2020 |
Title: | Combined BTK and BCL2 Inhibition in CLL: A Non-Chemotherapy Therapeutic Approach |
Funding Source: | Andrew Sabin Family Foundation Fellows Award |
Role: | PI |
Date: | 2017 - 2023 |
Title: | 2017-0938: A Phase 1/11 Study to Evaluate the Safety and Anti-tumor Activity of ADCT-602 targeting CD22 in Patients with Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia |
Funding Source: | ADC Therapeutics |
Role: | PI |
Date: | 2017 - Present |
Title: | 2016-0727 -- Long-term follow-up study of patients who have previously been exposed to UCART19/ALLO-501 (allogeneic engineered T-cells expressing a lentiviral-based anti-CD19 chimeric antigen receptor) |
Funding Source: | I.R.I.S |
Role: | PI |
Date: | 2017 - 2021 |
Title: | Protocol 2016-0725 -- Phase I, open label, dose-escalation study to evaluate the safety, expansion and persistence of a single dose of UCART19 (allogeneic engineered T-cells expressing anti-CD19 chimeric antigen receptor), administered intravenously in patients with relapsed or refractory CD19 positive B-cell acute lymphoblastic leukaemia (B-ALL) |
Funding Source: | I.R.I.S |
Role: | PI |
Date: | 2016 - Present |
Title: | 2015-1097: Atezolizumab (PD-L1 mAb) in Combination with Obinutuzumab and Venetoclax for Patients with Chronic Lymphocytic Leukemia and Richter Transformation |
Funding Source: | Genentech, Inc |
Role: | PI |
ID: | 4518 |
Date: | 2016 - Present |
Title: | 2015-0860: A Phase II Study of Venetoclax and Ibrutinib in Patients with |
Funding Source: | Abbvie |
Role: | PI |
Date: | 2016 - 2021 |
Title: | Preclinical and Clinical Development of Isoform Specific PI3Kinase Inhibitor, IPI-145 (Duvelisib) in Chronic Lymphocytic Leukemia |
Funding Source: | NIH/NCI |
Role: | CO-I |
ID: | 15750 PA-13-302 |
Date: | 2016 - Present |
Title: | 2015-0281: First-line Therapy with Ibrutinib, Fludarabine, Cyclophosphamide, and Obinutuzumab (GA-101) (iFCG) for Patients with Chronic Lymphocytic Leukemia (CLL) with Mutated IGHV gene and Non-del(17p) |
Funding Source: | Genentech, Inc |
Role: | PI |
ID: | 51523 |
Date: | 2016 - Present |
Title: | 2015-0281: First-line Therapy with Ibrutinib, Fludarabine, Cyclophosphamide, and Obinutuzumab (GA-101) (iFCG) for Patients with Chronic Lymphocytic Leukemia (CLL) with Mutated IGHV gene and Non-del(17p) |
Funding Source: | Pharmacyclics, Inc |
Role: | PI |
ID: | 51524 |
Date: | 2015 - 2019 |
Title: | Targeting apoptosis in ALL with venetoclax and cytotoxic chemotherapy |
Funding Source: | Leukemia and Lymphoma Society |
Role: | CO-I |
ID: | P-TRP-7089-15 |
Date: | 2015 - 2018 |
Title: | Immune Checkpoint Blockade in Chronic Lymphocytic Leukemia |
Funding Source: | Leukemia and Lymphoma Society |
Role: | PI |
ID: | P-TRP-6599-15 |
Date: | 2015 - 2018 |
Title: | Dual targeting of MAPK and AKT pathways in Ras-mutated AML |
Funding Source: | American Society of Clinical Oncology (ASCO) |
Role: | PI |
ID: | 01 |
Date: | 2015 - 2017 |
Title: | Targeting Oncogenic RAS mutations in AML: Mechanisms of Therapeutic Response and Resistance |
Funding Source: | NIH/NCI |
Role: | CO-I |
ID: | 1 R21 CA187704-01A1 |
Date: | 2015 - 2018 |
Title: | 2014-0794: A Phase 1b Study of IPI-145 Administered in Combination with Obinutuzumab in Patients with CLL/SLL Previously Treated with a Bruton’s Tyrosine Kinase Inhibitor (BTKi) |
Funding Source: | Infinity Pharmaceuticals, Inc |
Role: | PI |
ID: | 15224 |
Date: | 2015 - 2020 |
Title: | Defining and Treating Targetable Lesions in AYA Acute Lymphoblastic |
Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
Role: | CO-I |
ID: | RP150006 |
Date: | 2014 - 2017 |
Title: | 2014-0933: Lirilumab (anti-KIR mAb) Combined with Rituximab for Relapsed, Refractory or High-risk Untreated Patients with Chronic Lymphocytic Leukemia (CLL) |
Funding Source: | Bristol Myers Squibb Co |
Role: | PI |
ID: | 39997 |
Date: | 2014 - 2019 |
Title: | 2014-0931: Nivolumab in Combination with Ibrutinib in Patients with High-Risk Chronic Lymphocytic Leukemia (CLL) |
Funding Source: | Bristol Myers Squibb, Co |
Role: | PI |
ID: | 39993 |
Date: | 2014 - 2017 |
Title: | 2014-0932: Urelumab (CD137 mAb) Combined with Rituximab for Relapsed, Refractory or High-risk Untreated Patients with Chronic Lymphocytic Leukemia (CLL) |
Funding Source: | Bristol Myers Squibb, Co |
Role: | PI |
ID: | 39996 |
Date: | 2014 - 2020 |
Title: | 2013-0479: An Open-Label Study of Bosutinib Treatment Extension Study For Subjects With Chronic Myeloid Leukemia (CML) Who Have Previously Participated In Bosutinib Studies B1871006 Or B1871008 |
Funding Source: | Pfizer |
Role: | CO-I |
ID: | 8606 |
Date: | 2014 - 2019 |
Title: | 2014-0435: Combination of Bosutinib and Inotuzumab Ozogamicin in Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia and Chronic Myelogenous Leukemia Lymphoid Blast Crisis |
Funding Source: | Pfizer |
Role: | PI |
ID: | 12172 |
Date: | 2014 - 2017 |
Title: | Dual targeting of MAPK and AKT pathways in Ras-mutated AML |
Funding Source: | American Society of Clinical Oncology (ASCO) |
Role: | PI |
ID: | 01 |
Date: | 2014 - 2016 |
Title: | Targeting Oncogenic RAS mutations in AML: Mechanisms of Therapeutic Response and Resistance |
Funding Source: | NIH/NCI |
Role: | CO-I |
ID: | 1 R21 CA187704-01 |
Date: | 2014 - 2016 |
Title: | 2013-0706: Brentuximab Vedotin in CD30-Positive Relapsed/Refractory Acute Myeloid Leukemia |
Funding Source: | Seattle Genetics |
Role: | PI |
ID: | 9513 |
Date: | 2014 - 2016 |
Title: | A Phase II Study of MEK 1/2 Inhibitor GSK212 (trametinib) in Combination with AKT Inhibitor GSK795 in Acute Myeloid Leukemia (AML) with Ras Mutations |
Funding Source: | MDACC HI-CRSP |
Role: | PI |
ID: | 01 |
Date: | 2013 - 2014 |
Title: | 2013-0001: A Phase II Study of MEK 1/2 Inhibitor GSK212 (trametinib) in Combination with AKT Inhibitor GSK795 in Acute Myeloid Leukemia (AML) with Ras Mutations |
Funding Source: | NIH/NCI |
Role: | PI |
ID: | CTEP |
Date: | 2013 - 2017 |
Title: | 2012-1040: A Phase I Study of IPI-145 in Patients with Advanced Hematologic Malignancie |
Funding Source: | Infinity Pharmaceuticals, Inc |
Role: | PI |
ID: | 40116 |
Title: | 2015-0618: Phase 1, Open-label, Dose-escalation, Multicenter Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Activity of ADCT-301 in Patients with Relapsed or Refractory CD25-positive Acute Myeloid Leukemia |
Funding Source: | ADC Therapeutics |
Role: | PI |
ID: | ADCT301002 |
Title: | 2015-0618: A Phase 1, Open-label, Adaptive Dose-escalation, Multicenter Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Anti-tumor Activity of ADCT-402 in Patients with Relapsed or Refractory B-cell Lineage Acute Lymphoblastic Leukemia (B-ALL) |
Funding Source: | ADC Therapeutics |
Role: | PI |
ID: | ADCT402102 |
Title: | A Phase II Study of the Combination of Ruxolitinib or Dasatinib with Chemotherapy in Patients with Philadelphia Chromosome (Ph)-Like Acute Lymphoblastic Leukemia (ALL) |
Funding Source: | Incyte Corporation |
Role: | PI |
ID: | 1 |
Title: | Integrated Multi-Omics Profiling of Measurable Residual Disease Revelas Molecular Drivers and Therapeutic Resistance in CLL |
Funding Source: | CLL Global |
Role: | PI |
Title: | 2021-0578: Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients with Treatment-naïve Chronic Lymphocytic Leukemia (CLL) |
Funding Source: | Loxo Oncology / Lilly USA, LLC |
Role: | PI |
ID: | RCTS 60837 |
Title: | 2022-0806: A phase 1b study of oral AS-1763 in patients with previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma or non hodgkin lymphoma |
Funding Source: | Carna Biosciences, Inc |
Role: | PI |
Title: | Personalized Medicine for Adult B-cell |
Funding Source: | American Society of Hematology (ASH) |
Role: | PI |
ID: | 1 |
Selected Publications
Peer-Reviewed Articles
- Short, NJ, Kantarjian, HM, Furudate, K, Jain, N, Ravandi-Kashani, F, Karrar, OS, Loghavi, S, Nasr, L, Haddad, FG, Senapati, J, Garris, R, Takahashi, K, Jabbour, EJ. Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab. Journal of Hematology and Oncology 18(1), 2025. e-Pub 2025. PMID: 40369607.
- Chien, KS, Curry, JL, Pemmaraju, N, Jain, N. Leukemia Cutis in the Setting of Indolent Chronic Lymphocytic Leukemia. American journal of hematology 100(7):1240-1241, 2025. e-Pub 2025. PMID: 40062658.
- Senapati, J, Loghavi, S, Marvin-Peek, J, Garcia-Manero, G, Kadia, TM, Borthakur, G, Daver, N, Short, NJ, Jain, N, Issa, GC, Haddad, FG, Hammond, D, Chien, KS, Tang, G, Thakral, B, Montalban Bravo, G, Pemmaraju, N, Bazinet, A, Swaminathan, M, Pierce, S, Abbas, HA, Reville, PK, Popat, UR, Shpall, EJ, Champlin, RE, Jabbour, EJ, Ravandi-Kashani, F, Kantarjian, HM, DiNardo, C. Clinico-Genomic Interrogation of Secondary-Type Acute Myeloid Leukemia. American journal of hematology 100(5):758-769, 2025. e-Pub 2025. PMID: 39921561.
- Goulart, H, Kantarjian, HM, Borthakur, G, Daver, N, DiNardo, C, Jabbour, EJ, Pemmaraju, N, Alvarado, Y, Atluri, H, Yilmaz, M, Haddad, FG, Marx, K, Rausch, C, Loghavi, S, Jain, N, Garcia-Manero, G, Ravandi-Kashani, F, Kadia, TM. Cladribine, idarubicin, and cytarabine (CLIA) for patients with relapsed and/or refractory acute myeloid leukemia. Cancer 131(8), 2025. e-Pub 2025. PMID: 40193193.
- Goulart, H, Kantarjian, HM, Borthakur, G, Daver, N, DiNardo, C, Jabbour, EJ, Pemmaraju, N, Alvarado, Y, Atluri, H, Yilmaz, M, Haddad, FG, Marx, K, Rausch, C, Loghavi, S, Jain, N, Garcia-Manero, G, Ravandi-Kashani, F, Kadia, TM. Cladribine, idarubicin, and cytarabine (CLIA) for patients with relapsed and/or refractory acute myeloid leukemia. Cancer 131(8), 2025. e-Pub 2025. PMID: 40193193.
- Kantarjian, HM, Short, NJ, Jain, N, Haddad, FG, Kadia, TM, Yilmaz, M, Ferrajoli, A, Sasaki, K, Alvarado, Y, Pemmaraju, N, Senapati, J, Garris, R, Ravandi-Kashani, F, Jabbour, EJ. Hyper-CVAD and Sequential Blinatumomab Without and With Inotuzumab in Young Adults With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia. American journal of hematology 100(3):402-407, 2025. e-Pub 2025. PMID: 39757533.
- Kantarjian, H, Short, NJ, Haddad, FG, Jain, N, Huang, X, Montalban-Bravo, G, Kanagal-Shamanna, R, Kadia, TM, Daver, N, Chien, KS, Alvarado, Y, Garcia-Manero, G, Issa, GC, Garris, R, Nasnas, C, Nasr, L, Ravandi, F, Jabbour, EJ. Results of the Simultaneous Combination of Ponatinib and Blinatumomab in Philadelphia Chromosome-Positive ALL. Journal of Clinical Oncology 42(36):4246-4251, 2024. e-Pub 2024. PMID: 39028925.
- Braish, J, Kugler, E, Jabbour, EJ, Woodman, K, Ravandi-Kashani, F, Nicholas, S, Jain, N, Kantarjian, HM, Sasaki, K. Incidence and Clinical Presentation of Severe Neurotoxicity from Nelarabine in Patients with T-Cell Acute Lymphoblastic Leukemia. Clinical Lymphoma, Myeloma and Leukemia 24(11):783-788, 2024. e-Pub 2024. PMID: 39013740.
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- Ali, MA, Aiman, W, Kantarjian, HM, Jabbour, EJ, Ravandi-Kashani, F, Jain, N, Short, NJ, Sasaki, K. Efficacy of Chemotherapy-Free Regimens in the Treatment of Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia. Clinical Lymphoma, Myeloma and Leukemia 24(10):e376-e384, 2024. e-Pub 2024. PMID: 38972767.
- Rao I, Zhou AE, Jain NP, Grant-Kels JM. Ethics of patients losing insurance coverage due to hospital-insurer contract disagreements. Clin Dermatol 42(5):559-561, 2024. e-Pub 2024. PMID: 38777205.
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- Kadia TM, Huang M, Pemmaraju N, Abbas HA, Ly C, Masarova L, Yilmaz M, Lyu MA, Zeng K, Sadeghi T, Cook R, DiNardo CD, Daver N, Issa GC, Jabbour E, Borthakur G, Jain N, Garcia-Manero G, Parmar S, Flowers C, Kantarjian H, Verstovsek S. Phase 1 Study of CK0801 in Treatment of Bone Marrow Failure Syndromes. NEJM Evid 3(6):EVIDoa2300362, 2024. e-Pub 2024. PMID: 38804782.
- Gibson A, Nunez C, Robusto L, Kammerer B, Garcia M, Roth M, Sheth R, Tewari P, Hittle A, Toepfer L, Torres R, Short NJ, Jabbour E, Jain N, Cuglievan B, McCall D. Combination low-intensity chemotherapy plus inotuzumab ozogamicin, blinatumomab and rituximab for pediatric patients with relapsed/refractory B-cell acute lymphoblastic leukemia. Haematologica. e-Pub 2024. PMID: 38779719.
- Khouri IF, Alzahrani K, Kantarjian H, Milton DR, Gulbis AM, Sasaki K, Jain N, Short NJ, Kadia T, Daher M, Rafei H, Im JS, Marin D, Olson AL, Popat U, Qazilbash M, Ramdial J, Rondon G, Srour S, Kebriaei P, Shpall E, Champlin R, Jabbour EJ. Safety and long-term survival results of the addition of inotuzumab ozogamicin to the conditioning regimen of allogeneic stem cell transplantation: A single-center phase 1,2 trial. Am J Hematol 99(5):836-843, 2024. e-Pub 2024. PMID: 38400519.
- Short NJ, Jabbour E, Jamison T, Paul S, Cuglievan B, McCall D, Gibson A, Jain N, Haddad FG, Nasr LF, Marx KR, Rausch C, Savoy JM, Garris R, Ravandi F, Kantarjian H. Dose-Dense Mini-Hyper-CVD, Inotuzumab Ozogamicin and Blinatumomab Achieves Rapid MRD-Negativity in Philadelphia Chromosome-Negative B-cell Acute Lymphoblastic Leukemia. Clin Lymphoma Myeloma Leuk 24(4):e168-e173, 2024. e-Pub 2024. PMID: 38212207.
- Short NJ, Jabbour E, Nasr LF, Jain N, Haddad FG, Issa GC, Sasaki K, Senapati J, Kebriaei P, Garris R, Konopleva M, Ravandi F, Kantarjian H. Characteristics and outcomes of patients with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia after failure of a frontline ponatinib-containing therapy. Am J Hematol. e-Pub 2024. PMID: 38607091.
- Bazinet A, Garcia-Manero G, Short N, Alvarado Y, Bataller A, Abuasab T, Islam R, Montalbano K, Issa G, Maiti A, Yilmaz M, Jain N, Masarova L, Kornblau S, Jabbour E, Montalban-Bravo G, Rausch CR, Pierce S, DiNardo CD, Kadia T, Daver N, Konopleva M, Huang X, Kantarjian H, Ravandi F. Oral decitabine and cedazuridine plus venetoclax for older or unfit patients with acute myeloid leukaemia: a phase 2 study. Lancet Haematol 11(4):e276-e286, 2024. e-Pub 2024. PMID: 38452788.
- Huang X, Li Y, Zhang J, Yan L, Zhao H, Ding L, Bhatara S, Yang X, Yoshimura S, Yang W, Karol SE, Inaba H, Mullighan C, Litzow M, Zhu X, Zhang Y, Stock W, Jain N, Jabbour E, Kornblau SM, Konopleva M, Pui CH, Paietta E, Evans W, Yu J, Yang JJ. Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia. Cancer Cell 42(4):552-567.e6, 2024. e-Pub 2024. PMID: 38593781.
- Kittai AS, Bond D, Huang Y, Bhat SA, Blyth E, Byrd JC, Chavez JC, Davids MS, Dela Cruz JP, Dowling MR, Duffy C, Ho C, Jacobson C, Jaglowski S, Jain N, Lin KH, Miller C, McCarthy C, Omer Z, Parry E, Rai M, Rogers KA, Saha A, Schachter L, Scott H, Senapati J, Shadman M, Siddiqi T, Stephens DM, Vanguru V, Wierda W, Woyach JA, Thompson PA. Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy for Richter Transformation: An International, Multicenter, Retrospective Study. J Clin Oncol:JCO2400033. e-Pub 2024. PMID: 38552193.
- Hampel PJ, Swaminathan M, Rogers KA, Parry EM, Burger JA, Davids MS, Ding W, Ferrajoli A, Hyak JM, Jain N, Kenderian SS, Wang Y, Wierda WG, Woyach JA, Parikh SA, Thompson PA. A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia. Blood Adv. e-Pub 2024. PMID: 38537065.
- Zhao Y, Short NJ, Kantarjian HM, Chang TC, Ghate PS, Qu C, Macaron W, Jain N, Thakral B, Phillips A, Khoury JD, Garcia-Manero G, Zhang W, Fan Y, Yang H, Garris R, Nasr LF, Kriwacki R, Roberts KG, Konopleva MY, Jabbour EJ, Mullighan CG. Genomic determinants of response and resistance to inotuzumab ozogamicin in B-cell ALL. Blood. e-Pub 2024. PMID: 38551807.
- Jain N, Croner LJ, Allan JN, Siddiqi T, Tedeschi A, Badoux XC, Eckert K, Cheung LWK, Mukherjee A, Dean JP, Szafer-Glusman E, Seymour JF. Absence of BTK, BCL2, and PLCG2 Mutations in Chronic Lymphocytic Leukemia Relapsing after First-Line Treatment with Fixed-Duration Ibrutinib plus Venetoclax. Clin Cancer Res 30(3):498-505, 2024. e-Pub 2024. PMID: 37955424.
- Jabbour E, Haddad FG, Short NJ, Senapati J, Jain N, Sasaki K, Jorgensen J, Wang SA, Alvarado Y, Wang X, DiNardo C, Masarova L, Kadia T, Garris RS, Ravandi F, Kantarjian H. Phase 2 study of inotuzumab ozogamicin for measurable residual disease in acute lymphoblastic leukemia in remission. Blood 143(5):417-421, 2024. e-Pub 2024. PMID: 37879077.
- Short NJ, Jabbour E, Jain N, Senapati J, Nasr L, Haddad FG, Li Z, Hsiao YC, Yang JJ, Pemmaraju N, Ohanian M, Wierda WG, Montalban-Bravo G, Borthakur G, Han L, Xiao L, Huang X, Abramova R, Zhao M, Garris R, Konopleva M, Ravandi F, Kantarjian H. A phase 1/2 study of mini-hyper-CVD plus venetoclax in patients with relapsed/refractory acute lymphoblastic leukemia. Blood Adv 8(4):909-915, 2024. e-Pub 2024. PMID: 38207208.
- Tian Z, Shi C, Yang G, Allen JK, Shi Q, Al-Shami A, Olson JW, Smith MG, Chang Q, Kaur J, You J, Lofton TE, Gonzalez MA, Zhang Q, Zha D, Tasian SK, Jain N, Konopleva MY, Heffernan T, Molldrem JJ. Correction: Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL. Leukemia 38(1):226, 2024. e-Pub 2024. PMID: 38036631.
- Short, NJ, Muftuoglu, M, Ong, F, Nasr, L, Macaron, W, Montalban Bravo, G, Alvarado, Y, Basyal, M, Daver, N, DiNardo, C, Borthakur, G, Jain, N, Ohanian, M, Jabbour, EJ, Issa, GC, Qiao, W, Huang, X, Kanagal Shamanna, R, Patel, KP, Bose, P, Ravandi-Kashani, F, Delumpa, R, Abramova, R, Garcia-Manero, G, Andreeff, M, Cortes, JE, Kantarjian, HM. A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents. Journal of Hematology and Oncology 16(1), 2023. e-Pub 2023. PMID: 37422688.
- Sasaki, K, Haddad, FG, Short, NJ, Jain, N, Issa, GC, Jabbour, EJ, Kantarjian, HM. Outcome of Philadelphia chromosome-positive chronic myeloid leukemia in the United States since the introduction of imatinib therapy—The Surveillance, Epidemiology, and End Results database, 2000–2019. Cancer 129(23):3805-3814, 2023. e-Pub 2023. PMID: 37769040.
- Short, NJ, Muftuoglu, M, Ong, F, Nasr, L, Macaron, W, Montalban Bravo, G, Alvarado, Y, Basyal, M, Daver, N, DiNardo, C, Borthakur, G, Jain, N, Ohanian, M, Jabbour, EJ, Issa, GC, Qiao, W, Huang, X, Kanagal Shamanna, R, Patel, KP, Bose, P, Ravandi-Kashani, F, Delumpa, R, Abramova, R, Garcia-Manero, G, Andreeff, M, Cortes, JE, Kantarjian, HM. A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents. Journal of Hematology and Oncology 16(1), 2023. e-Pub 2023. PMID: 37422688.
- Short, NJ, Muftuoglu, M, Ong, F, Nasr, L, Macaron, W, Montalban Bravo, G, Alvarado, Y, Basyal, M, Daver, N, DiNardo, C, Borthakur, G, Jain, N, Ohanian, M, Jabbour, EJ, Issa, GC, Qiao, W, Huang, X, Kanagal Shamanna, R, Patel, KP, Bose, P, Ravandi-Kashani, F, Delumpa, R, Abramova, R, Garcia-Manero, G, Andreeff, M, Cortes, JE, Kantarjian, HM. A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents. Journal of Hematology and Oncology 16(1), 2023. e-Pub 2023. PMID: 37422688.
- Short, NJ, Muftuoglu, M, Ong, F, Nasr, L, Macaron, W, Montalban Bravo, G, Alvarado, Y, Basyal, M, Daver, N, DiNardo, C, Borthakur, G, Jain, N, Ohanian, M, Jabbour, EJ, Issa, GC, Qiao, W, Huang, X, Kanagal Shamanna, R, Patel, KP, Bose, P, Ravandi-Kashani, F, Delumpa, R, Abramova, R, Garcia-Manero, G, Andreeff, M, Cortes, JE, Kantarjian, HM. A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents. Journal of Hematology and Oncology 16(1), 2023. e-Pub 2023. PMID: 37422688.
- Senapati, J, Fiskus, WC, Daver, N, Wilson, NR, Ravandi-Kashani, F, Garcia-Manero, G, Kadia, TM, DiNardo, C, Jabbour, EJ, Burger, JA, Short, NJ, Alvarado, Y, Jain, N, Masarova, L, Issa, GC, Qiao, W, Khoury, J, Pierce, SR, Miller, D, Sasaki, K, Konopleva, M, Bhalla, K, Borthakur, G, Pemmaraju, N. Phase I Results of Bromodomain and Extra-Terminal Inhibitor PLX51107 in Combination with Azacitidine in Patients with Relapsed/Refractory Myeloid Malignancies. Clinical Cancer Research 29(21):4352-4360, 2023. e-Pub 2023. PMID: 37585491.
- Kadia, TM, Ravandi-Kashani, F, Molica, M, Bataller, A, Borthakur, G, Daver, N, Jabbour, EJ, DiNardo, C, Pemmaraju, N, Jain, N, Ferrajoli, A, Ylimaz, M, Bose, P, Tidwell, R, Marx, KR, Rausch, CR, Kanagal Shamanna, R, Wang, S, Islam, R, Champlin, RE, Shpall, E, Konopleva, M, Garcia-Manero, G, Kantarjian, HM. Phase II study of cladribine, idarubicin, and ara-C (CLIA) with or without sorafenib as initial therapy for patients with acute myeloid leukemia. American journal of hematology 98(11):1711-1720, 2023. e-Pub 2023. PMID: 37635400.
- Parry, EM, Lemvigh, C, Deng, S, Dangle, N, Ruthen, NG, Knisbacher, BA, Broséus, J, Hergalant, S, Guièze, R, Li, S, Zhang, W, Johnson, C, Long, JM, Yin, S, Werner, L, Anandappa, AJ, Purroy, N, Gohil, SH, Oliveira, G, Bachireddy, P, Shukla, SA, Huang, T, Khoury, J, Thakral, B, Dickinson, M, Tam, C, Livak, KJ, Getz, G, Neuberg, D, Feugier, P, Kharchenko, PV, Wierda, WG, Olsen, LR, Jain, N, Wu, C. ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome. Cancer cell 41(10):1803-1816.e8, 2023. e-Pub 2023. PMID: 37738974.
- Tian, Z, Shi, C, Yang, G, Allen, J, Shi, Q, AI-Shami, A, Olson, JW, Smith, M, Chang, Q, Kaur, J, You, J, Lofton, T, Gonzalez, MA, Zhang, Q, Zha, D, Tasian, SK, Jain, N, Konopleva, M, Heffernan, TP, Molldrem, JJ. Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL. Leukemia 37(10):2006-2016, 2023. e-Pub 2023. PMID: 37634013.
- Jia Y, Han L, Ramage CL, Wang Z, Weng CC, Yang L, Colla S, Ma H, Zhang W, Andreeff M, Daver N, Jain N, Pemmaraju N, Bhalla K, Mustjoki S, Zhang P, Zheng G, Zhou D, Zhang Q, Konopleva M. Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells. Haematologica 108(10):2626-2638, 2023. e-Pub 2023. PMID: 37078252.
- Haddad, FG, Sasaki, K, Bidikian, A, Issa, GC, Kadia, TM, Jain, N, Alvarado, Y, Short, NJ, Pemmaraju, N, Loghavi, S, Patel, KP, Kanagal Shamanna, R, Yilmaz, M, Masarova, L, Jabbour, EJ, Kantarjian, HM. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation treated in the pre- and post-ponatinib era. American journal of hematology 98(10):1619-1626, 2023. e-Pub 2023. PMID: 37485584.
- Short, NJ, Jabbour, EJ, Macaron, W, Ravandi-Kashani, F, Jain, N, Kanagal Shamanna, R, Patel, KP, Loghavi, S, Haddad, FG, Yilmaz, M, Issa, GC, Kebriaei, P, Kornblau, SM, Pelletier, S, Flores, W, Matthews, JA, Garris, R, Kantarjian, HM. Ultrasensitive NGS MRD assessment in Ph+ ALL: Prognostic impact and correlation with RT-PCR for BCR::ABL1. American journal of hematology 98(8):1196-1203, 2023. e-Pub 2023. PMID: 37183966.
- Pasvolsky O, Kebriaei P, Shah BD, Jabbour EJ, Jain N. Chimeric Antigen Receptor T Therapy for Adult B-Cell Acute Lymphoblastic Leukemia: State-of the-(C)ART and Road Ahead. Blood Adv 7(14):3350-3360, 2023. e-Pub 2023. PMID: 36912764.
- Thompson, PA, Keating, M, Ferrajoli, A, Jain, N, Peterson, CB, Garg, N, Wang, SA, Jorgensen, JL, Kadia, TM, Bose, P, Pemmaraju, N, Short, NJ, Wierda, WG. Venetoclax consolidation in high-risk CLL treated with ibrutinib for ≥1 year achieves a high rate of undetectable MRD. Leukemia 37(7):1444-1453, 2023. e-Pub 2023. PMID: 37138019.
- Olesinski EA, Bhatia KS, Mahesh AN, Rosli S, Mohamed JS, Jen WY, Jain N, Garcia JS, Wong GC, Ooi M, Letai A, Konopleva M, Bhatt S. BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia. Blood Adv 7(12):2917-2923, 2023. e-Pub 2023. PMID: 36763538.
- Jabbour E, Short NJ, Senapati J, Jain N, Huang X, Daver N, DiNardo CD, Pemmaraju N, Wierda W, Garcia-Manero G, Montalban Bravo G, Sasaki K, Kadia TM, Khoury J, Wang SA, Haddad FG, Jacob J, Garris R, Ravandi F, Kantarjian HM. Mini-hyper-CVD plus inotuzumab ozogamicin, with or without blinatumomab, in the subgroup of older patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: long-term results of an open-label phase 2 trial. Lancet Haematol 10(6):e433-e444, 2023. e-Pub 2023. PMID: 37187201.
- Yoshimura S, Panetta JC, Hu J, Li L, Gocho Y, Du G, Umezawa A, Karol SE, Pui CH, Mullighan CG, Konopleva M, Stock W, Teachey DT, Jain N, Yang JJ. Preclinical pharmacokinetic and pharmacodynamic evaluation of dasatinib and ponatinib for the treatment of T-cell acute lymphoblastic leukemia. Leukemia 37(6):1194-1203, 2023. e-Pub 2023. PMID: 37076694.
- El Hussein S, Medeiros LJ, Lyapichev KA, Fang H, Jelloul FZ, Fiskus W, Chen J, Wei P, Schlette E, Xu J, Li S, Kanagal-Shamanna R, Yang H, Tang Z, Thakral B, Loghavi S, Jain N, Thompson PA, Ferrajoli A, Wierda WG, Jabbour E, Patel KP, Dabaja BS, Bhalla KN, Khoury JD. Immunophenotypic and genomic landscape of Richter transformation diffuse large B-cell lymphoma. Pathology 55(4):514-524, 2023. e-Pub 2023. PMID: 36933995.
- El Hussein S, Medeiros LJ, Gruschkus SK, Wei P, Schlette E, Fang H, Jelloul FZ, Wang W, Fiskus W, Kanagal-Shamanna R, Loghavi S, Yang H, Li S, Xu J, Tang Z, Thakral B, Jain N, Wierda WG, Patel K, Bhalla KN, Khoury JD. Immune evasion phenotype is common in Richter transformation diffuse large B-cell lymphoma variant. Virchows Arch 482(6):1011-1019, 2023. e-Pub 2023. PMID: 36864257.
- Desikan SP, Senapati J, Jabbour E, Abuasab T, Short N, Tang G, Wang S, Kebriaei P, Kadia T, Borthakur G, Ravandi F, Roberts K, Mullighan C, Konopleva M, Kantarjian H, Jain N. Outcomes of adult patients with relapsed/refractory CRLF2 rearranged B-cell acute lymphoblastic leukemia. Am J Hematol 98(6):E142-E144, 2023. e-Pub 2023. PMID: 36877196.
- Jain N, Senapati J, Thakral B, Ferrajoli A, Thompson P, Burger J, Basu S, Kadia T, Daver N, Borthakur G, Konopleva M, Pemmaraju N, Parry E, Wu CJ, Khoury J, Bueso-Ramos C, Garg N, Wang X, Lopez W, Ayala A, O'Brien S, Kantarjian H, Keating M, Allison J, Sharma P, Wierda W. A Phase 2 Study of Nivolumab Combined with Ibrutinib in Patients with Diffuse Large B-cell Richter Transformation of CLL. Blood Adv 7(10):1958-1966, 2023. e-Pub 2023. PMID: 36287248.
- Kantarjian H, Haddad FG, Jain N, Sasaki K, Short NJ, Loghavi S, Kanagal-Shamanna R, Jorgensen J, Khouri I, Kebriaei P, Alvarado Y, Kadia T, Paul S, Garcia-Manero G, Dabaja B, Yilmaz M, Jacob J, Garris R, O'Brien S, Ravandi F, Jabbour E. Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia. J Hematol Oncol 16(1):44, 2023. e-Pub 2023. PMID: 37131217.
- Senapati J, Jabbour E, Konopleva M, Short NJ, Tang G, Daver N, Kebriaei P, Kadia T, Pemmaraju N, Takahashi K, DiNardo C, Sasaki K, Borthakur G, Thakral B, Kanagal-Shamanna R, Patel K, Ravandi F, Roberts K, Mullighan C, Kantarjian H, Jain N. Philadelphia-Like Genetic Rearrangements in Adults With B-Cell ALL: Refractoriness to Chemotherapy and Response to Tyrosine Kinase Inhibitor in ABL Class Rearrangements. JCO Precis Oncol 7:e2200707, 2023. e-Pub 2023. PMID: 37196217.
- Sasaki K, Ravandi F, Kadia TM, Borthakur G, Short NJ, Jain N, Daver NG, Jabbour EJ, Garcia-Manero G, Loghavi S, Patel KP, Montalban-Bravo G, Masarova L, DiNardo CD, Kantarjian HM. Prediction of survival with lower intensity therapy among older patients with acute myeloid leukemia. Cancer 129(7):1017-1029, 2023. e-Pub 2023. PMID: 36715486.
- Gordon MJ, Jones JE, George B, Peterson C, Burger JA, Jain N, Keating M, Wierda WG, Durand JB, Ferrajoli A. Long-term outcomes in patients with chronic lymphocytic leukemia treated with ibrutinib: Focus on hypertension and cardiovascular toxicity. Cancer. e-Pub 2023. PMID: 37016930.
- Jabbour EJ, Sasaki K, Haddad FG, Issa GC, Garcia-Manero G, Kadia TM, Jain N, Yilmaz M, DiNardo CD, Patel KP, Kanagal-Shamanna R, Champlin R, Khouri IF, Dellasala S, Pierce SA, Kantarjian H. The outcomes of patients with chronic myeloid leukemia treated with third-line BCR::ABL1 tyrosine kinase inhibitors. Am J Hematol 98(4):658-665, 2023. e-Pub 2023. PMID: 36683287.
- Kantarjian H, Short NJ, Jain N, Sasaki K, Huang X, Haddad FG, Khouri I, DiNardo CD, Pemmaraju N, Wierda W, Garcia-Manero G, Kebriaei P, Garris R, Loghavi S, Jorgensen J, Kwari M, O'Brien S, Ravandi F, Jabbour E. Frontline combination of ponatinib and hyper-CVAD in Philadelphia chromosome-positive acute lymphoblastic leukemia: 80-months follow-up results. Am J Hematol 98(3):493-501, 2023. e-Pub 2023. PMID: 36600670.
- Boddu PC, Senapati J, Ravandi-Kashani F, Jabbour EJ, Jain N, Ayres M, Chen Y, Keating MJ, Kantarjian HM, Gandhi V, Kadia TM. A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies. Cancer 129(4):580-589, 2023. e-Pub 2023. PMID: 36448227.
- Parry EM, Leshchiner I, Guièze R, Johnson C, Tausch E, Parikh SA, Lemvigh C, Broséus J, Hergalant S, Messer C, Utro F, Levovitz C, Rhrissorrakrai K, Li L, Rosebrock D, Yin S, Deng S, Slowik K, Jacobs R, Huang T, Li S, Fell G, Redd R, Lin Z, Knisbacher BA, Livitz D, Schneider C, Ruthen N, Elagina L, Taylor-Weiner A, Persaud B, Martinez A, Fernandes SM, Purroy N, Anandappa AJ, Ma J, Hess J, Rassenti LZ, Kipps TJ, Jain N, Wierda W, Cymbalista F, Feugier P, Kay NE, Livak KJ, Danysh BP, Stewart C, Neuberg D, Davids MS, Brown JR, Parida L, Stilgenbauer S, Getz G, Wu CJ. Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nat Med 29(1):158-169, 2023. e-Pub 2023. PMID: 36624313.
- Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H. Ponatinib and blinatumomab for Philadelphia chromosome-positive acute lymphoblastic leukaemia: a US, single-centre, single-arm, phase 2 trial. Lancet Haematol 10(1):e24-e34, 2023. e-Pub 2023. PMID: 36402146.
- Marx KR, Rausch CR, Lovell AR, Short NJ, Paul S, Jain N, Lee J, Savoy JM, Ravandi F, Jabbour E. Incidence of adverse effects in patients receiving ponatinib with concomitant azole antifungals. Leuk Lymphoma 64(1):1-8, 2023. e-Pub 2023. PMID: 36222579.
- Paul S, Kantarjian H, Sasaki K, Marx K, Jain N, Savoy JM, DiPippo A, Jammal N, Bravo GM, Kadia T, Garcia-Manero G, Short NJ, Ravandi F, Jabbour E. Intrathecal prophylaxis with 12 versus 8 administrations reduces the incidence of central nervous system relapse in patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia. Am J Hematol 98(1):E11-E14, 2023. e-Pub 2023. PMID: 35633516.
- Jabbour E, Short NJ, Jain N, Thompson PA, Kadia TM, Ferrajoli A, Huang X, Yilmaz M, Alvarado Y, Patel KP, Garcia-Manero G, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H. Hyper-CVAD and sequential blinatumomab for newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: a single-arm, single-centre, phase 2 trial. Lancet Haematol 9(12):e878-e885, 2022. e-Pub 2022. PMID: 36279879.
- Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M, Group CS. UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial. Lancet Haematol 9(11):e833-e843, 2022. e-Pub 2022. PMID: 36228643.
- Jabbour E, Sasaki K, Haddad FG, Issa GC, Skinner J, Dellasala S, Yilmaz M, Ferrajoli A, Bose P, Thompson P, Alvarado Y, Jain N, Garcia-Manero G, Takahashi K, Borthakur G, Pemmaraju N, Pierce S, Kantarjian H. Low-dose dasatinib 50?mg/day versus standard-dose dasatinib 100?mg/day as frontline therapy in chronic myeloid leukemia in chronic phase: A propensity score analysis. Am J Hematol 97(11):1413-1418, 2022. e-Pub 2022. PMID: 36054032.
- Pemmaraju N, Wilson NR, Senapati J, Economides MP, Guzman ML, Neelapu SS, Kazemimood R, Davis RE, Jain N, Khoury JD, Sugita M, Cai T, Smith J, Frattini MG, Garton A, Roboz G, Konopleva M. CD123-directed allogeneic chimeric-antigen receptor T-cell therapy (CAR-T) in blastic plasmacytoid dendritic cell neoplasm (BPDCN): Clinicopathological insights. Leuk Res 121:106928, 2022. e-Pub 2022. PMID: 35963025.
- Bazinet A, Kantarjian H, Borthakur G, Yilmaz M, Bose P, Jabbour E, Alvarado Y, Chien K, Pemmaraju N, Takahashi K, Short N, Daver N, Issa G, Jain N, Bull-Linderman D, DiNardo C, Montalban-Bravo G, Garcia-Manero G, Sasaki K, Ravandi F, Kadia T. AML-342 A Phase II Study of Azacitidine and Venetoclax as Maintenance Therapy in Patients With Acute Myeloid Leukemia. Clin Lymphoma Myeloma Leuk 22 Suppl 2:S239-S240, 2022. e-Pub 2022. PMID: 36163817.
- Timofeeva N, Jain N, Irajizad E, Aslan B, Katayama H, Cai Y, Ayres M, Iles L, Vykoukal J, Dennison J, Hanash S, Wierda W, Gandhi V. CLL-532 Changes in Proteome of CLL (Chronic Lymphocytic Leukemia) Lymphocytes During Investigator-Initiated Trial of Ibrutinib Alone and in Combination With Venetoclax in Treatment-Naïve Patients With CLL. Clin Lymphoma Myeloma Leuk 22 Suppl 2:S283, 2022. e-Pub 2022. PMID: 36163901.
- Abuasab T, Alvarado Y, Issa G, Islam R, James N, Yilmaz M, Jain N, Masarova L, Kornblau S, Jabbour E, Pemmaraju N, Bravo GM, Pierce S, DiNardo C, Kadia T, Daver N, Konopleva M, Garcia-Manero G, Ravandi F. AML-328 Phase 2 Study of ASTX727 (Decitabine/Cedazuridine) Plus Venetoclax in Patients With Relapsed/Refractory Acute Myeloid Leukemia or Previously Untreated, Older Adult Patients Unfit for Chemotherapy. Clin Lymphoma Myeloma Leuk 22 Suppl 2:S237, 2022. e-Pub 2022. PMID: 36163813.
- Baran N, Babakhanlou R, Sasaki K, Takahashi K, Short N, Ravandi F, Garcia-Manero G, Jabbour EJ, Kantarjian HM, Jain N. ALL-346 Acute Lymphoblastic Leukemia Following Multiple Myeloma Therapy: A Single-Center Experience With 9 Patients. Clin Lymphoma Myeloma Leuk 22 Suppl 2:S201-S202, 2022. e-Pub 2022. PMID: 36163741.
- Rozovski U, Veletik I, Harris D, Li P, Liu Z, Jain P, Manshouri T, Ferrajoli A, Burger J, Bose P, Thompson P, Jain N, Wierda W, Verstovsek S, Keating M, Estrov Z. CLL-162 PTX3 is Constitutively Active in CLL Cells. Clin Lymphoma Myeloma Leuk 22 Suppl 2:S271, 2022. e-Pub 2022. PMID: 36163878.
- Haddad FG, Kantarjian H, Short NJ, Konopleva M, Jain N, Huang X, Ravandi F, Wierda W, Borthakur G, Sasaki K, Issa G, Alvarado Y, Pemmaraju N, Garcia-Manero G, Thankachan J, Garris R, Jabbour E. ALL-424 Updated Results from the Phase II Study of Blinatumomab in Combination With Ponatinib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Clin Lymphoma Myeloma Leuk 22 Suppl 2:S204, 2022. e-Pub 2022. PMID: 36163747.
- Saini NY, Swoboda DM, Greenbaum U, Ma J, Patel RD, Devashish K, Das K, Tanner MR, Strati P, Nair R, Fayad L, Ahmed S, Lee HJ, Iyer SP, Steiner R, Jain N, Nastoupil L, Loghavi S, Tang G, Bassett RL, Jain P, Wang M, Westin JR, Green MR, Sallman DA, Padron E, Davila ML, Locke FL, Champlin RE, Garcia-Manero G, Shpall EJ, Kebriaei P, Flowers CR, Jain MD, Wang F, Futreal AP, Gillis N, Neelapu SS, Takahashi K. Clonal hematopoiesis is associated with increased risk of severe neurotoxicity in axicabtagene ciloleucel therapy of large B-cell lymphoma. Blood Cancer Discov 3(5):385-393, 2022. e-Pub 2022. PMID: 35533245.
- Jabbour EJ, Short NJ, Jain N, Jammal N, Jorgensen J, Wang S, Wang X, Ohanian M, Alvarado Y, Kadia T, Sasaki K, Garris R, Garcia-Manero G, Ravandi F, Kantarjian HM. Blinatumomab is associated with favorable outcomes in patients with B-cell lineage acute lymphoblastic leukemia and positive measurable residual disease at a threshold of 10-4 and higher. Am J Hematol 97(9):1135-1141, 2022. e-Pub 2022. PMID: 35713551.
- Cherng HJ, Khwaja R, Kanagal-Shamanna R, Tang G, Burger J, Thompson P, Ferrajoli A, Estrov Z, Sasaki K, Sampath D, Wang X, Kantarjian H, Keating M, Wierda WG, Jain N. TP53-altered CLL Treated with Firstline Bruton's Tyrosine Kinase Inhibitor-based Therapy: A Retrospective Analysis. Am J Hematol 97(8):1005-1012, 2022. e-Pub 2022. PMID: 35567779.
- Kadia TM, Reville PK, Wang X, Rausch CR, Borthakur G, Pemmaraju N, Daver NG, DiNardo CD, Sasaki K, Issa GC, Ohanian M, Montalban-Bravo G, Short NJ, Jain N, Ferrajoli A, Bhalla KN, Jabbour E, Takahashi K, Malla R, Quagliato K, Kanagal-Shamanna R, Popat UR, Andreeff M, Garcia-Manero G, Konopleva MY, Ravandi F, Kantarjian HM. Phase II Study of Venetoclax Added to Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia. J Clin Oncol:JCO2102823. e-Pub 2022. PMID: 35704787.
- Short NJ, Macaron W, Konopleva M, Ravandi F, Jain N, Issa GC, Kadia T, Sasaki K, Kebriaei P, Yilmaz M, Thompson PA, Takahashi K, Abbas HA, Wierda WG, Garris R, Kantarjian HM, Jabbour E. Dismal outcomes of patients with relapsed/refractory Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia after failure of both inotuzumab ozogamicin and blinatumomab. Am J Hematol 97(6):E201-E204, 2022. e-Pub 2022. PMID: 35266566.
- Berkman AM, Andersen CR, Cuglievan B, McCall DC, Lupo PJ, Parsons SK, DiNardo CD, Short NJ, Jain N, Kadia TM, Livingston JA, Roth ME. Long-Term Outcomes among Adolescent and Young Adult Survivors of Acute Leukemia: A Surveillance, Epidemiology, and End Results Analysis. Cancer Epidemiol Biomarkers Prev 31(6):OF1-OF9, 2022. e-Pub 2022. PMID: 35553621.
- Rozovski U, Veletic I, Harris DM, Li P, Liu Z, Jain P, Manshouri T, Ferrajoli A, Burger JA, Bose P, Thompson PA, Jain N, Wierda WG, Verstovsek S, Keating MJ, Estrov Z. STAT3 Activates the Pentraxin 3 Gene in Chronic Lymphocytic Leukemia Cells. J Immunol. e-Pub 2022. PMID: 35595309.
- DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Kadia T, Daver N, Xiao L, Adeoti M, Short NJ, Sasaki K, Wang SA, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Garcia-Manero G, Kornblau S, Ravandi F, Jabbour E, Konopleva MY, Kantarjian HM. Venetoclax Combined with FLAG-IDA Induction and Consolidation in Newly Diagnosed Acute Myeloid Leukemia. Am J Hematol. e-Pub 2022. PMID: 35583199.
- Yilmaz M, Kantarjian H, Short NJ, Reville P, Konopleva M, Kadia T, DiNardo C, Borthakur G, Pemmaraju N, Maiti A, Jabbour E, Jain N, Issa G, Takahashi K, Sasaki K, Ohanian M, Pierce S, Tang G, Loghavi S, Patel K, Wang SA, Garcia-Manero G, Andreeff M, Ravandi F, Daver N. Hypomethylating agent and venetoclax with FLT3 inhibitor "triplet" therapy in older/unfit patients with FLT3 mutated AML. Blood Cancer J 12(5):77, 2022. e-Pub 2022. PMID: 35501304.
- Sasaki Y, Kantarjian HM, Short NJ, Wang F, Furudate K, Uryu H, Garris R, Jain N, Sasaki K, Ravandi F, Konopleva M, Garcia-Manero G, Little L, Gumbs C, Zhao L, Futreal PA, Takahashi K, Jabbour E. Correction: Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD plus dasatinib or ponatinib. Leukemia 36(5):1448, 2022. e-Pub 2022. PMID: 35411096.
- Jelloul FZ, Yang R, Garces S, Kanagal-Shamanna R, Ok CY, Loghavi S, Routbort MJ, Zuo Z, Yin CC, Floyd K, Bassett RL, Wierda W, Jain N, Thompson P, Luthra R, Medeiros LJ, Patel KP. Landscape of NOTCH1 mutations and co-occurring biomarker alterations in chronic lymphocytic leukemia. Leuk Res 116:106827, 2022. e-Pub 2022. PMID: 35430388.
- Short NJ, Kantarjian HM, Ravandi F, Konopleva MY, Jain N, Kanagal-Shamanna R, Patel KP, Macaron W, Kadia TM, Wang SA, Jorgensen JL, Khoury JD, Yilmaz M, Kebriaei P, Takahashi K, Garcia-Manero G, Daver NG, Post SM, Huang X, Kornblau SM, Pelletier S, Flores W, Matthews J, Garris R, Jabbour EJ. High-sensitivity next-generation sequencing MRD assessment in ALL identifies patients at very low risk of relapse. Blood Adv. e-Pub 2022. PMID: 35533262.
- Kim K, Konopleva M, DiNardo CD, Borthakur G, Loghavi S, Tang G, Daver N, Pemmaraju N, Jabbour E, Rausch CR, Yilmaz M, Sasaki K, Short NJ, Jain N, Brandt M, Pierce S, Garcia-Manero G, Ravandi F, Kantarjian H, Kadia TM. Urgent cytoreduction for newly diagnosed acute myeloid leukemia patients allows acquisition of pretreatment genomic data and enrollment on investigational clinical trials. Am J Hematol. e-Pub 2022. PMID: 35413152.
- Sasaki K, Ravandi F, Kadia T, DiNardo C, Borthakur G, Short N, Jain N, Daver N, Jabbour E, Garcia-Manero G, Khoury J, Konoplev S, Loghavi S, Patel K, Montalban-Bravo G, Masarova L, Konopleva M, Kantarjian H. Prediction of survival with intensive chemotherapy in acute myeloid leukemia. Am J Hematol. e-Pub 2022. PMID: 35384048.
- Mukherjee A, Milton DR, Jabbour EJ, Gulbis AM, Kadia T, Jain N, Ledesma C, Burger J, Ferrajoli A, Wierda W, Medeiros LJ, Kantarjian H, Champlin R, Khouri IF. Clinical outcome of allogeneic stem cell transplantation in patients with B-cell lymphoid malignancies following treatment with targeted small molecule inhibitors. Leuk Lymphoma 63(4):885-893, 2022. e-Pub 2022. PMID: 35225133.
- Jelloul FZ, Yang RK, Wang P, Garces S, Kanagal-Shamanna R, Ok CY, Loghavi S, Routbort MJ, Zuo Z, Yin CC, Floyd K, Bassett RL, Wierda WG, Jain N, Thompson PA, Luthra R, Medeiros LJ, Patel KP. Non-coding NOTCH1 mutations in chronic lymphocytic leukemia negatively impact prognosis. Am J Hematol 97(3):E100-E102, 2022. e-Pub 2022. PMID: 34989420.
- Haddad FG, Sasaki K, Issa GC, Garcia-Manero G, Ravandi F, Kadia T, Cortes J, Konopleva M, Pemmaraju N, Alvarado Y, Yilmaz M, Borthakur G, DiNardo C, Jain N, Daver N, Short NJ, Jabbour E, Kantarjian H. Treatment-free remission in patients with chronic myeloid leukemia following the discontinuation of tyrosine kinase inhibitors. Am J Hematol. e-Pub 2022. PMID: 35357036.
- Sasaki Y, Kantarjian HM, Short NJ, Wang F, Furudate K, Uryu H, Garris R, Jain N, Sasaki K, Ravandi F, Konopleva M, Garcia-Manero G, Little L, Gumbs C, Zhao L, Futreal PA, Takahashi K, Jabbour E. Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD plus dasatinib or ponatinib. Leukemia. e-Pub 2022. PMID: 35132195.
- Sasaki K, Kadia T, Begna K, DiNardo CD, Borthakur G, Short NJ, Jain N, Daver N, Jabbour E, Garcia-Manero G, Bravo GM, Masarova L, Pierce S, Konopleva M, Ravandi F, Tefferi A, Kantarjian H. Prediction of early (4-week) mortality in acute myeloid leukemia with intensive chemotherapy. Am J Hematol 97(1):68-78, 2022. e-Pub 2022. PMID: 34716921.
- Pemmaraju N, Wilson NR, Garcia-Manero G, Sasaki K, Khoury JD, Jain N, Borthakur G, Ravandi F, Daver NG, Kadia TM, DiNardo CD, Jabbour EJ, Pierce SR, Qazilbash MH, Konopleva MY, Kantarjian HM. Characteristics and Outcomes of Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm Treated with Frontline HCVAD. Blood Adv. e-Pub 2022. PMID: 35061885.
- Yi X, Jain N, Iles LR, Ayres ML, Wierda WG, Gandhi V. Targeting Mcl-1 by AMG-176 During Ibrutinib and Venetoclax Therapy in Chronic Lymphocytic Leukemia. Front Oncol 12:833714, 2022. e-Pub 2022. PMID: 35273915.
- Desikan SP, Ravandi F, Pemmaraju N, Konopleva M, Loghavi S, Jabbour EJ, Daver N, Jain N, Chien KS, Maiti A, Montalban-Bravo G, Kadia TM, Macaron W, DeLumpa R, Kwari M, Borthakur G, Short NJ. A Phase II Study of Azacitidine, Venetoclax, and Trametinib in Relapsed or Refractory Acute Myeloid Leukemia Harboring RAS Pathway-Activating Mutations. Acta Haematol 145(5):529-536, 2022. e-Pub 2022. PMID: 35717939.
- Gibson A, Trabal A, McCall D, Khazal S, Toepfer L, Bell DH, Roth M, Mahadeo KM, Nunez C, Short NJ, DiNardo C, Konopleva M, Issa GC, Ravandi F, Jain N, Borthakur G, Kantarjian HM, Jabbour E, Cuglievan B. Venetoclax for Children and Adolescents with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma. Cancers (Basel) 14(1), 2021. e-Pub 2021. PMID: 35008312.
- Gaballa MR, Banerjee PP, Milton DR, Jiang X, Ganesh C, Khazal SJ, Nandivada V, Islam S, Kaplan M, Daher M, Basar R, Alousi A, Mehta RS, Alatrash G, Khouri IF, Oran B, Marin D, Popat UR, Olson AL, Tewari P, Jain N, Jabbour EJ, Ravandi F, Kantarjian HM, Chen K, Champlin RE, Shpall EJ, Rezvani K, Kebriaei P. Blinatumomab Maintenance After Allogeneic Hematopoietic Cell Transplantation for B-lineage Acute Lymphoblastic Leukemia. Blood. e-Pub 2021. PMID: 34914826.
- Mato AR, Davids MS, Sharman J, Roeker LE, Kay N, Kater AP, Rogers K, Thompson MC, Rhodes J, Goy A, Skarbnik A, Schuster SJ, Tam CS, Eyre TA, O'Brien S, Nabhan C, Lamanna N, Sun C, Shadman M, Pagel JM, Ujjani C, Brander D, Coombs CC, Jain N, Cheah CY, Brown JR, Seymour JF, Woyach JA. Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: "What's Past is Prologue" (Shakespeare). Clin Cancer Res. e-Pub 2021. PMID: 34789482.
- Ramos Perez JM, Patel KP, Loghavi S, Garcia-Manero G, Borthakur G, Jabbour E, Wierda W, Pierce S, Brandt M, Kornblau S, Kadia T, Daver N, DiNardo CD, Jain N, Yilmaz M, Short N, Verstovsek S, Ferrajoli A, Andreeff M, Konopleva M, Rivera D, McCue D, Kantarjian HM, Ravandi F. Value of measurable residual disease monitoring in patients with acute promyelocytic leukemia in the era of frontline 'chemotherapy-free' therapy. Leuk Lymphoma:1-4. e-Pub 2021. PMID: 34668451.
- Brown PA, Shah B, Advani A, Aoun P, Boyer MW, Burke PW, DeAngelo DJ, Dinner S, Fathi AT, Gauthier J, Jain N, Kirby S, Liedtke M, Litzow M, Logan A, Luger S, Maness LJ, Massaro S, Mattison RJ, May W, Oluwole O, Park J, Przespolewski A, Rangaraju S, Rubnitz JE, Uy GL, Vusirikala M, Wieduwilt M, Lynn B, Berardi RA, Freedman-Cass DA, Campbell M. Acute Lymphoblastic Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 19(9):1079-1109, 2021. e-Pub 2021. PMID: 34551384.
- Richard-Carpentier G, Kantarjian HM, Tang G, Yin CC, Khoury JD, Issa GC, Haddad FG, Jain N, Ravandi F, Short NJ, DiNardo CD, Takahashi K, Konopleva MY, Daver NG, Kadia TM, Garcia-Manero G, Garris R, O'Brien SM, Jabbour EJ. Outcomes of Acute Lymphoblastic Leukemia with KMT2A (MLL) rearrangement - The MD Anderson Experience. Blood Adv. e-Pub 2021. PMID: 34525185.
- Sivina M, Kim E, Wierda WG, Ferrajoli A, Jain N, Thompson PA, Kantarjian HM, Keating MJ, Burger JA. Ibrutinib induces durable remissions in treatment-naïve patients with CLL and 17p deletion/TP53 mutations. Blood. e-Pub 2021. PMID: 34521099.
- Chien KS, Kim K, Nogueras-Gonzalez GM, Borthakur G, Naqvi K, Daver NG, Montalban-Bravo G, Cortes JE, DiNardo CD, Jabbour E, Alvarado Y, Andreeff M, Bose P, Jain N, Kadia TM, Huang X, Sheppard KB, Klingner-Winton C, Pierce SA, Dong XQ, Soltysiak KA, Kantarjian HM, Garcia-Manero G. Phase II study of azacitidine with pembrolizumab in patients with intermediate-1 or higher-risk myelodysplastic syndrome. Br J Haematol. e-Pub 2021. PMID: 34340254.
- Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson PA, Jain N, Kantarjian HM, Jabbour EJ. Long term outcome of Hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse. Blood Adv. e-Pub 2021. PMID: 34464974.
- Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM. Venetoclax plus intensive chemotherapy with cladribine, idarubicin, and cytarabine in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a cohort from a single-centre, single-arm, phase 2 trial. Lancet Haematol 8(8):e552-e561, 2021. e-Pub 2021. PMID: 34329576.
- Jain N. Evolving Treatment Paradigm in Frontline CLL. JCO Oncol Pract:OP2100486. e-Pub 2021. PMID: 34449250.
- Pemmaraju N, Carter BZ, Bose P, Jain N, Kadia TM, Garcia-Manero G, Bueso-Ramos CE, DiNardo CD, Bledsoe S, Daver NG, Popat U, Konopleva MY, Zhou L, Pierce S, Estrov ZE, Borthakur GM, Ohanian M, Qiao W, Masarova L, Wang X, Mak PY, Cortes J, Jabbour E, Verstovsek S. Final results of a phase 2 clinical trial of LCL161, an oral SMAC mimetic for patients with myelofibrosis. Blood Adv 5(16):3163-3173, 2021. e-Pub 2021. PMID: 34424319.
- Short NJ, Konopleva M, Kadia T, Kebriaei P, Daver N, Huang X, Masarova L, Cook R, Jain N, Jabbour E, Kantarjian H, Ravandi F. An effective chemotherapy-free regimen of ponatinib plus venetoclax for relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Am J Hematol 96(7):E229-E232, 2021. e-Pub 2021. PMID: 33780038.
- Niswander LM, Loftus JP, É L, Caye-Eude A, Pondrom M, Hottman DA, Iacobucci I, Mullighan CG, Jain N, Konopleva M, Cavé H, Baruchel A, Rohrlich PS, Tasian SK. Therapeutic potential of ruxolitinib and ponatinib in patients with EPOR-rearranged Philadelphia chromosome-like acute lymphoblastic leukemia. Haematologica. e-Pub 2021. PMID: 34196168.
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- Sasaki K, Kantarjian HM, Morita K, Short NJ, Konopleva M, Jain N, Ravandi F, Garcia-Manero G, Wang S, Khoury JD, Jorgensen JL, Champlin RE, Khouri IF, Kebriaei P, Schroeder HM, Khouri M, Garris R, Takahashi K, O'Brien SM, Jabbour EJ. Hyper-CVAD plus ofatumumab versus hyper-CVAD plus rituximab as frontline therapy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: A propensity score analysis. Cancer. e-Pub 2021. PMID: 34138471.
- Jain N. How I manage chronic lymphocytic leukemia. Clin Adv Hematol Oncol 19(6):360-364, 2021. e-Pub 2021. PMID: 34106909.
- Pemmaraju N, Wilson NR, Khoury JD, Jain N, Daver NG, Pierce SR, Jabbour EJ, Kadia TM, DiNardo CD, Garcia-Manero G, Qazilbash MH, Konopleva MY, Kantarjian HM. Central Nervous System Involvement in Blastic Plasmacytoid Dendritic Cell Neoplasm. Blood. e-Pub 2021. PMID: 34098573.
- Jabbour E, Patel K, Jain N, Duose D, Luthra R, Short NJ, Zugmaier G, San Lucas A, Velasco K, Tran Q, Zaman F, Konopleva M, Kantarjian H. Impact of Philadelphia chromosome-like alterations on efficacy and safety of blinatumomab in adults with relapsed/refractory acute lymphoblastic leukemia: A post hoc analysis from the phase 3 TOWER study. Am J Hematol. e-Pub 2021. PMID: 34161631.
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- Cherng HJ, Jammal N, Paul S, Wang X, Sasaki K, Thompson P, Burger J, Ferrajoli A, Estrov Z, O'Brien S, Keating M, Wierda WG, Jain N. Clinical and molecular characteristics and treatment patterns of adolescent and young adult patients with chronic lymphocytic leukaemia. Br J Haematol. e-Pub 2021. PMID: 33973230.
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- Jain P, Keating M, Renner S, Cleeland C, Xuelin H, Gonzalez GN, Harris D, Li P, Liu Z, Veletic I, Rozovski U, Jain N, Thompson P, Bose P, DiNardo C, Ferrajoli A, O'Brien S, Burger J, Wierda W, Verstovsek S, Kantarjian H, Estrov Z. Ruxolitinib for symptom control in patients with chronic lymphocytic leukaemia: a single-group, phase 2 trial. Lancet Haematol 4(2):e67-e74, 2017. e-Pub 2017. PMID: 28089238.
- Montalban-Bravo G, Huang X, Jabbour E, Borthakur G, DiNardo CD, Pemmaraju N, Cortes J, Verstovsek S, Kadia T, Daver N, Wierda W, Alvarado Y, Konopleva M, Ravandi F, Estrov Z, Jain N, Alfonso A, Brandt M, Sneed T, Chen HC, Yang H, Bueso-Ramos C, Pierce S, Estey E, Bohannan Z, Kantarjian HM, Garcia-Manero G. A clinical trial for patients with acute myeloid leukemia or myelodysplastic syndromes not eligible for standard clinical trials. Leukemia 31(2):318-324, 2017. e-Pub 2017. PMID: 27795561.
- Issa GC, Kantarjian HM, Yin CC, Qiao W, Ravandi F, Thomas D, Short NJ, Sasaki K, Garcia-Manero G, Kadia TM, Cortes JE, Daver N, Borthakur G, Jain N, Konopleva M, Khouri I, Kebriaei P, Champlin RE, Pierce S, O'Brien SM, Jabbour E. Prognostic impact of pretreatment cytogenetics in adult Philadelphia chromosome-negative acute lymphoblastic leukemia in the era of minimal residual disease. Cancer 123(3):459-467, 2017. e-Pub 2017. PMID: 27696391.
- Jain N, Roberts KG, Jabbour E, Patel K, Eterovic AK, Chen K, Zweidler-McKay P, Lu X, Fawcett G, Wang SA, Konoplev S, Harvey RC, Chen IM, Payne-Turner D, Valentine M, Thomas D, Garcia-Manero G, Ravandi F, Cortes J, Kornblau S, O'Brien S, Pierce S, Jorgensen J, Shaw KR, Willman CL, Mullighan CG, Kantarjian H, Konopleva M. Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults. Blood 129(5):572-581, 2017. e-Pub 2017. PMID: 27919910.
- Yin Q, Sivina M, Robins H, Yusko E, Vignali M, O'Brien S, Keating MJ, Ferrajoli A, Estrov Z, Jain N, Wierda WG, Burger JA. Ibrutinib Therapy Increases T Cell Repertoire Diversity in Patients with Chronic Lymphocytic Leukemia. J Immunol 198(4):1740-1747, 2017. e-Pub 2017. PMID: 28077600.
- Chen Q, Jain N, Ayer T, Wierda WG, Flowers CR, O'Brien SM, Keating MJ, Kantarjian HM, Chhatwal J. Economic Burden of Chronic Lymphocytic Leukemia in the Era of Oral Targeted Therapies in the United States. J Clin Oncol 35(2):JCO2016682856, 2017. e-Pub 2017. PMID: 27870563.
- Khan M, Paul S, Farooq S, Oo TH, Ramshesh P, Jain N. Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency. Curr Drug Saf. e-Pub 2017. PMID: 28078984.
- Jabbour E, Short NJ, Jorgensen JL, Yilmaz M, Ravandi F, Wang SA, Thomas DA, Khoury J, Champlin RE, Khouri I, Kebriaei P, O'Brien SM, Garcia-Manero G, Cortes JE, Sasaki K, Dinardo CD, Kadia TM, Jain N, Konopleva M, Garris R, Kantarjian HM. Differential impact of minimal residual disease negativity according to the salvage status in patients with relapsed/refractory B-cell acute lymphoblastic leukemia. Cancer 123(2):294-302, 2017. e-Pub 2017. PMID: 27602508.
- Boddu P, Yin CC, Kanagal-Shamanna R, Tang G, Thakral B, Kadia T, Konopleva M, Jabbour E, Jain N. An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma. Case Rep Hematol 2017:2413587, 2017. e-Pub 2017. PMID: 29075538.
- Sasaki K, Jabbour EJ, Ravandi F, Short NJ, Thomas DA, Garcia-Manero G, Daver NG, Kadia TM, Konopleva MY, Jain N, Issa GC, Jeanis V, Moore HG, Garris RS, Pemmaraju N, Cortes JE, O'Brien SM, Kantarjian HM. Hyper-CVAD plus ponatinib versus hyper-CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: A propensity score analysis. Cancer 122(23):3650-3656, 2016. e-Pub 2016. PMID: 27479888.
- Short NJ, Kantarjian HM, Sasaki K, Ravandi F, Ko H, Yin CC, Garcia-Manero G, Cortes JE, Garris R, O'Brien SM, Patel K, Khouri M, Thomas D, Jain N, Kadia TM, Daver N, Benton CB, Issa GC, Konopleva M, Jabbour E. Poor outcomes associated with +der(22)t(9;22) and -9/9p in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia receiving chemotherapy plus a tyrosine kinase inhibitor. Am J Hematol. e-Pub 2016. PMID: 28006851.
- Short NJ, Kantarjian HM, Sasaki K, Cortes JE, Ravandi F, Thomas DA, Garcia-Manero G, Khouri I, Kebriaei P, Champlin RE, Pierce S, Issa GC, Konopleva M, Kadia TM, Bueso-Ramos C, Khoury JD, Jain N, O'Brien SM, Jabbour E. Prognostic significance of day 14 bone marrow evaluation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia. Cancer 122(24):3812-3820, 2016. e-Pub 2016. PMID: 27508525.
- Patel VM, Balakrishnan K, Douglas M, Tibbitts T, Xu EY, Kutok JL, Ayers M, Sarkar A, Guerrieri R, Wierda WG, O'Brien S, Jain N, Stern HM, Gandhi V. Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199). Leukemia. e-Pub 2016. PMID: 28017967.
- Abaza Y, Kantarjian HM, Garcia-Manero G, Estey E, Borthakur G, Jabbour E, Faderl S, O'Brien S, Wierda W, Pierce S, Brandt M, McCue D, Luthra R, Patel K, Kornblau S, Kadia T, Daver N, DiNardo C, Jain N, Verstovsek S, Ferrajoli A, Andreeff M, Konopleva M, Estrov Z, Foudray M, McCue D, Cortes J, Ravandi F. Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab. Blood. e-Pub 2016. PMID: 28003274.
- Jain N, Balakrishnan K, Ferrajoli A, O'Brien SM, Burger JA, Kadia TM, Cortes JE, Ayres ML, Tambaro FP, Keating MJ, Gandhi V, Wierda WG. A phase I-II trial of fludarabine, bendamustine and rituximab (FBR) in previously treated patients with CLL. Oncotarget. e-Pub 2016. PMID: 27655665.
- Pemmaraju N, Jain P, Medeiros LJ, Jorgenson JL, Jain N, Willis J, Kontoyiannis DP, Estrov Z, Wierda W. PET-positive lymphadenopathy in CLL - Not always Richter transformation. American Journal of Hematology, 2016. e-Pub 2016.
- Sasaki K, Popat U, Jain P, Kadia T, Patel K, Patel K, Jain N, Takahashi K, Young K, Miranda RN, Oo TH, Lu H, Pemmaraju N. Successful treatment of aplastic anemia-paroxysmal nocturnal hemoglobinuria associated with eosinophilic fasciitis with matched unrelated donor allogeneic peripheral blood stem cell transplantation. Clin Case Rep 4(8):765-7, 2016. e-Pub 2016. PMID: 27525080.
- Jain P, Kanagal-Shamanna R, Wierda W, Ferrajoli A, Keating M, Jain N. Membranoproliferative glomerulonephritis and acute renal failure in a patient with chronic lymphocytic leukemia: Response to obinutuzumab. Hematol Oncol Stem Cell Ther. e-Pub 2016. PMID: 27352257.
- Vitale C, Ahn IE, Sivina M, Ferrajoli A, Wierda WG, Estrov Z, Konoplev SN, Jain N, O'Brien S, Farooqui M, Keating MJ, Wiestner A, Burger JA. Autoimmune cytopenias in patients with chronic lymphocytic leukemia treated with ibrutinib. Haematologica 101(6):e254-8, 2016. e-Pub 2016. PMID: 27013651.
- Alhuraiji A, Jain N. Immunofluorescence staining with an antipromyelocytic leukemia antibody for a rapid diagnosis of acute promyelocytic leukemia. Hematol Oncol Stem Cell Ther. e-Pub 2016. PMID: 27362439.
- Short NJ, Kantarjian HM, Jabbour EJ, O'Brien SM, Faderl S, Burger JA, Garris R, Qiao W, Huang X, Jain N, Konopleva M, Kadia TM, Daver N, Borthakur G, Cortes JE, Ravandi F. Prognostic impact of persistent cytogenetic abnormalities at complete remission in adult patients with acute lymphoblastic leukemia. Am J Hematol 91(4):385-9, 2016. e-Pub 2016. PMID: 26800008.
- Jain N, Lamb AV, O'Brien S, Ravandi F, Konopleva M, Jabbour E, Zuo Z, Jorgensen J, Lin P, Pierce S, Thomas D, Rytting M, Borthakur G, Kadia T, Cortes J, Kantarjian HM, Khoury JD. Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype. Blood 127(15):1863-9, 2016. e-Pub 2016. PMID: 26747249.
- Ravandi F, Jorgensen JL, O'Brien SM, Jabbour E, Thomas DA, Borthakur G, Garris R, Huang X, Garcia-Manero G, Burger JA, Ferrajoli A, Wierda W, Kadia T, Jain N, Wang SA, Konoplev S, Kebriaei P, Champlin RE, McCue D, Estrov Z, Cortes JE, Kantarjian HM. Minimal residual disease assessed by multi-parameter flow cytometry is highly prognostic in adult patients with acute lymphoblastic leukaemia. Br J Haematol 172(3):392-400, 2016. e-Pub 2016. PMID: 26492205.
- Thompson PA, O'Brien SM, Xiao L, Wang X, Burger JA, Jain N, Ferrajoli A, Estrov Z, Keating MJ, Wierda WG. β2 -microglobulin normalization within 6 months of ibrutinib-based treatment is associated with superior progression-free survival in patients with chronic lymphocytic leukemia. Cancer 122(4):565-73, 2016. e-Pub 2016. PMID: 26588193.
- Jabbour E, Kantarjian H, Ravandi F, Thomas D, Huang X, Faderl S, Pemmaraju N, Daver N, Garcia-Manero G, Sasaki K, Cortes J, Garris R, Yin CC, Khoury JD, Jorgensen J, Estrov Z, Bohannan Z, Konopleva M, Kadia T, Jain N, DiNardo C, Wierda W, Jeanis V, O'Brien S. Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a single-centre, phase 2 study. Lancet Oncol 16(15):1547-55, 2015. e-Pub 2015. PMID: 26432046.
- Thompson PA, O'Brien SM, Wierda WG, Ferrajoli A, Stingo F, Smith SC, Burger JA, Estrov Z, Jain N, Kantarjian HM, Keating MJ. Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens. Cancer 121(20):3612-21, 2015. e-Pub 2015. PMID: 26193999.
- Rozovski U, Grgurevic S, Bueso-Ramos C, Harris DM, Li P, Liu Z, Wu JY, Jain P, Wierda W, Burger J, O'Brien S, Jain N, Ferrajoli A, Keating MJ, Estrov Z. Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells. Mol Cancer Res 13(5):944-53, 2015. e-Pub 2015. PMID: 25733697.
- Jain P, Keating M, Wierda W, Estrov Z, Ferrajoli A, Jain N, George B, James D, Kantarjian H, Burger J, O'Brien S. Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib. Blood 125(13):2062-7, 2015. e-Pub 2015. PMID: 25573991.
- Pemmaraju N, Shah D, Kantarjian H, Orlowski RZ, Nogueras González GM, Baladandayuthapani V, Jain N, Wagner V, Garcia-Manero G, Shah J, Ravandi F, Pierce S, Takahashi K, Daver N, Nazha A, Verstovsek S, Jabbour E, De Lima M, Champlin R, Cortes J, Qazilbash MH. Characteristics and Outcomes of Patients With Multiple Myeloma Who Develop Therapy-Related Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia. Clin Lymphoma Myeloma Leuk 15(2):110-4, 2015. e-Pub 2015. PMID: 25107338.
- Yin CC, Jain N, Mehrotra M, Zhagn J, Protopopov A, Zuo Z, Pemmaraju N, DiNardo C, Hirsch-Ginsberg C, Wang SA, Medeiros LJ, Chin L, Patel KP, Ravandi F, Futreal A, Bueso-Ramos CE. Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia. J Natl Compr Canc Netw 13(1):19-22, 2015. e-Pub 2015. PMID: 25583766.
- Strati P, Keating MJ, O'Brien SM, Ferrajoli A, Burger J, Faderl S, Tambaro FP, Jain N, Wierda WG. Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion. Haematologica 99(8):1350-5, 2014. e-Pub 2014. PMID: 24859876.
- Strati P, Keating MJ, O'Brien SM, Burger J, Ferrajoli A, Jain N, Tambaro FP, Estrov Z, Jorgensen J, Challagundla P, Faderl SH, Wierda WG. Eradication of bone marrow minimal residual disease with first-line chemoimmunotherapy may prompt early treatment discontinuation in chronic lymphocytic leukemia. Blood 123(24):3727-32, 2014. e-Pub 2014. PMID: 24705492.
- Rozovski U, Wu JY, Harris DM, Liu Z, Li P, Hazan-Halevy I, Ferrajoli A, Burger JA, O'Brien S, Jain N, Verstovsek S, Wierda WG, Keating MJ, Estrov Z. Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells. Blood 123(24):3797-802, 2014. e-Pub 2014. PMID: 24778152.
- Falchi L, Keating MJ, Marom EM, Truong MT, Schlette EJ, Sargent RL, Trinh L, Wang X, Smith SC, Jain N, Estrov Z, O'Brien S, Wierda WG, Lerner S, Ferrajoli A. Correlation between FDG/PET findings, histological features, clinical characteristics and survival in 332 patients with chronic lymphocytic leukemia. Blood 123(18):2783-90, 2014. e-Pub 2014. PMID: 24615780.
- DiNardo CD, Daver N, Jain N, Pemmaraju N, Bueso-Ramos C, Yin CC, Pierce S, Jabbour E, Cortes JE, Kantarjian HM, Garcia-Manero G, Verstovsek S. Myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN, U): natural history and clinical outcome by treatment strategy. Leukemia 28(4):958-61, 2014. e-Pub 2014. PMID: 24492324.
- Pemmaraju N, Shetty AV, Prieto VG, Jain N, Kontoyiannis DP, Borthakur G. Disseminated Saprochaete capitata (formerly known as Geotrichum capitatum, and Blastoschizomyces capitatus) in a patient with acute myeloid leukemia. Eur J Haematol. e-Pub 2014. PMID: 24592915.
- Jain N, Curran E, Iyengar NM, Diaz-Flores E, Kunnavakkam R, Popplewell L, Kirschbaum MH, Karrison T, Erba HP, Green M, Poire X, Koval G, Shannon K, Reddy PL, Joseph L, Atallah EL, Dy P, Thomas SP, Smith SE, Doyle LA, Stadler WM, Larson RA, Stock W, Odenike O. Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial. Clin Cancer Res 20(2):490-8, 2014. e-Pub 2014. PMID: 24178622.
- Alayed K, Patel KP, Konoplev S, Singh RR, Routbort MJ, Reddy N, Pemmaraju N, Zhang L, Shaikh AA, Aladily TN, Jain N, Luthra R, Medeiros LJ, Khoury JD. TET2 mutations, myelodysplastic features, and a distinct immunoprofile characterize blastic plasmacytoid dendritic cell neoplasm in the bone marrow. Am J Hematol 88(12):1055-61, 2013. e-Pub 2013. PMID: 23940084.
- Jain N, Khoury JD, Pemmaraju N, Kollipara P, Kantarjian H, Verstovsek S. Imatinib Therapy in a Patient with Suspected Chronic Neutrophilic Leukemia and FIP1L1-PDGFRA Rearrangement. Blood 122(19):3387-8, 2013. e-Pub 2013. PMID: 24203930.
- Jain N, Liu H, Artz AS, Anastasi J, Odenike O, Godley LA, Joseph L, Marino S, Kline J, Nguyen V, Schouten V, Kunnavakkam R, Larson RA, Stock W, Ulaszek J, Savage PA, Wickrema A, van Besien K. Immune Reconstitution after Combined Haploidentical and Umbilical Cord Blood Transplantation. Leuk Lymphoma 54(6):1242-9, 2013. e-Pub 2013. PMID: 23088744.
- Hossain N, Jain N, Steinmetz J, McConville J, Anastasi J, Odenike O. A 32-year-old man with persistent cough, shortness of breath, eosinophilic pneumonia, and peripheral blood eosinophilia. Myeloid neoplasm associated with eosinophilia and platelet-derived growth factor receptor-alpha rearrangement. Chest 142(6):1680-3, 2012. e-Pub 2012. PMID: 23208343.
- Santos FP, Kantarjian HM, Jain N, Manshouri T, Thomas DA, Garcia-Manero G, Kennedy D, Estrov Z, Cortes J, Verstovsek S. Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis. Blood 115(6):1131-6, 2010. e-Pub 2010. PMID: 20008298.
- Sever M, Kantarjian H, Pierce S, Jain N, Estrov Z, Cortes J, Verstovsek S. Cytogenetic abnormalities in essential thrombocythemia at presentation and transformation. Int J Hematol 90(4):522-5, 2009. e-Pub 2009. PMID: 19728024.
- Jain N, Wierda W, Ferrajoli A, Wong F, Lerner S, Keating M, O'Brien S. A phase 2 study of yttrium-90 ibritumomab tiuxetan (Zevalin) in patients with chronic lymphocytic leukemia. Cancer 115(19):4533-9, 2009. e-Pub 2009. PMID: 19637351.
- Jain N, Reuben JM, Kantarjian H, Li C, Gao H, Lee BN, Cohen EN, Ebarb T, Scheinberg DA, Cortes J. Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a phase 2 trial. Cancer 115(17):3924-34, 2009. e-Pub 2009. PMID: 19536894.
- Borthakur G, Lin E, Jain N, Estey EE, Cortes JE, O'Brien S, Faderl S, Ravandi F, Pierce S, Kantarjian H. Survival is poorer in patients with secondary core-binding factor acute myelogenous leukemia compared with de novo core-binding factor leukemia. Cancer 115(14):3217-21, 2009. e-Pub 2009. PMID: 19441109.
- Jain N, Cortes J, Quintás-Cardama A, Manshouri T, Luthra R, Garcia-Manero G, Kantarjian H, Verstovsek S. Imatinib has limited therapeutic activity for hypereosinophilic syndrome patients with unknown or negative PDGFRalpha mutation status. Leuk Res 33(6):837-9, 2009. e-Pub 2009. PMID: 19013640.
- Fava C, Kantarjian HM, Jabbour E, O'Brien S, Jain N, Rios MB, Garcia-Manero G, Ravandi F, Verstovsek S, Borthakur G, Shan J, Cortes J. Failure to achieve a complete hematologic response at the time of a major cytogenetic response with second-generation tyrosine kinase inhibitors is associated with a poor prognosis among patients with chronic myeloid leukemia in accelerated or blast phase. Blood 113(21):5058-63, 2009. e-Pub 2009. PMID: 19282457.
- Jain N, Hubbard J, Vega F, Vidal G, Garcia-Manero G, Borthakur G. Spontaneous Remission of Acute Myeloid Leukemia: report of three patients and review of literature. Clinical Leukemia 2(1):64-67, 2008. e-Pub 2008.
- Jain N, Kantarjian H, Ault P, Cortes J. Scrotal edema associated with the use of dasatinib in patients with chronic myeloid leukemia. Clinical Leukemia 1(6):357-58, 2007. e-Pub 2007.
- Jain N, Fisk D, Sotir M, Kehl KS. West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. Transplant International 20(9):800-3, 2007. e-Pub 2007. PMID: 17630998.
- Jain N, Patel D, Pfeifer KJ. An unusual case of vertebral osteomyelitis in a young healthy adult. Wisconsin Medical Journal 106(3):152-54, 2007. e-Pub 2007. PMID: 17642354.
- Prasad K, Singhal T, Jain N, Gupta PK. Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis, 2004. e-Pub 2004.
Invited Articles
- Strati P, Jain N, O'Brien S. Chronic Lymphocytic Leukemia: Diagnosis and Treatment. Mayo Clin Proc 93(5):651-664, 2018. e-Pub 2018. PMID: 29728204.
- Boddu P, Jain N. Update on signal inhibitors in chronic lymphocytic leukemia. Clin Adv Hematol Oncol 16(4):279-288, 2018. e-Pub 2018. PMID: 29742083.
- Jain N. Examining the Safety of CLL Medication. CURE Today, 2017. e-Pub 2017.
- Wells J, Jain N, Konopleva M. Philadelphia chromosome-like acute lymphoblastic leukemia: progress in a new cancer subtype. Clin Adv Hematol Oncol 15(7):554-561, 2017. e-Pub 2017. PMID: 28749919.
- Vangapandu HV, Jain N, Gandhi V. Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia. Expert Opin Investig Drugs 26(5):625-632, 2017. e-Pub 2017. PMID: 28388280.
- Jain N, O'Brien S. First-line therapy for young patients with CLL. Hematology Am Soc Hematol Educ Program 2016(1):146-148, 2016. e-Pub 2016. PMID: 27913473.
- Agbay RL, Jain N, Loghavi S, Medeiros LJ, Khoury JD. Histologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma. Am J Hematol 91(10):1036-43, 2016. e-Pub 2016. PMID: 27414262.
- Jain N, Keating MJ. Richter transformation of CLL. Expert Rev Hematol 9(8):793-801, 2016. e-Pub 2016. PMID: 27351634.
- Jain N, O'Brien S. Targeted therapies for CLL: Practical issues with the changing treatment paradigm. Blood Rev 30(3):233-44, 2016. e-Pub 2016. PMID: 26776345.
- George B, Kantarjian H, Jabbour E, Jain N. Role of inotuzumab ozogamicin in the treatment of relapsed/refractory acute lymphoblastic leukemia. Immunotherapy 8(2):135-43, 2016. e-Pub 2016. PMID: 26780449.
- Jain N, O'Brien S. Initial treatment of CLL: integrating biology and functional status. Blood 126(4):463-70, 2015. e-Pub 2015. PMID: 26065656.
- Jain N. New developments in Richter syndrome. Clin Adv Hematol Oncol 13(4):220-2, 2015. e-Pub 2015. PMID: 26352579.
- Jain N, O'Brien S, Thomas D, Kantarjian H. Inotuzumab Ozogamicin in the treatment of acute lymphoblastic leukemia. Front Biosci (Elite Ed) 6:40-5, 2014. e-Pub 2014. PMID: 24389139.
- Jain N, O'Brien S. The frontline treatment of chronic myeloid leukemia in the chronic phase: current clinical decisions and future prospects for treatment. Expert Rev Hematol 6(5):575-86, 2013. e-Pub 2013. PMID: 24083594.
- Jain N, O'Brien S. Ibrutinib (PCI-32765) in Chronic Lymphocytic Leukemia. Hematol Oncol Clin North Am 27(4):851-60, 2013. e-Pub 2013. PMID: 23915749.
- Van Besien K, Liu H, Jain N, Stock W, Artz A. Umbilical Cord Blood Transplantation Supported by Third-Party Donor Cells: Rationale, Results, and Applications. Biol Blood Marrow Transplant 19(5):682-91, 2013. e-Pub 2013. PMID: 23142329.
- Jain N, O'Brien S. Chronic lymphocytic leukemia with deletion 17p: emerging treatment options. Oncology (Williston Park) 11(11):1067-70, 2012. e-Pub 2012. PMID: 23330347.
- Jain N, van Besien K. Chronic Myelogenous Leukemia. Elsevier's First Consult online, 2012. e-Pub 2012.
- Quintás-Cardama A, Jain N, Verstovsek S. Advances and controversies in the diagnosis, pathogenesis, and treatment of systemic mastocytosis. Cancer 117(24):5439-49, 2011. e-Pub 2011. PMID: 21692073.
- Jain N, van Besien K. Chronic myelogenous leukemia: role of stem cell transplant in the imatinib era. Hematol Oncol Clin North Am 25(5):1025-48, vi, 2011. e-Pub 2011. PMID: 22054733.
- Jain N, Odenike O. The Emerging Role of the Histone deactylase inhibitor Romidepsin in Hematologic Malignancies. Expert Opinion on Pharmacotherapy 11(18):3073-84, 2010. e-Pub 2010.
- Garcia JS, Jain N, Godley LA. An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes. OncoTargets and Therapy 24(3):1-13, 2010. e-Pub 2010.
- Jain N, Lamanna N. Incorporating Prognostic Information into Treatment Decisions in CLL. Current Oncology Reports 11(5):353-9, 2009. e-Pub 2009.
- Jain N, Rossi A, Garcia-Manero G. Epigenetic therapy of leukemia: An update. The International Journal of Biochemistry and Cell Biology 41(1):72-80, 2009. e-Pub 2009.
- Jain N, Verstovsek S. Systemic Mastocytosis. Drugs of the Future 33(2):187-92, 2008. e-Pub 2008.
Review Articles
- Kantarjian, HM, Jain, N, Litzow, M, Luger, SM, Papayannidis, C, Ribera, JM, Short, NJ, Chifotides, H, Jabbour, EJ. The evolving therapeutic revolution in adult acute lymphoblastic leukemia. Cancer 131(10), 2025. e-Pub 2025. PMID: 40323723.
- Short NJ, Jabbour E, Jain N, Kantarjian H. Inotuzumab ozogamicin for the treatment of adult acute lymphoblastic leukemia: past progress, current research and future directions. J Hematol Oncol 17(1):32, 2024. e-Pub 2024. PMID: 38734670.
- Haddad FG, Jabbour E, Short NJ, Jain N, Kantarjian H. SOHO State of the Art Updates and Next Questions: Update on the Approach to Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Clin Lymphoma Myeloma Leuk 24(5):271-276, 2024. e-Pub 2024. PMID: 38185587.
- Senapati J, Kantarjian H, Haddad FG, Short NJ, Welch MA, Jain N, Jabbour E. SOHO State of the Art Updates and Next Questions | Next Questions: Acute Lymphoblastic Leukemia. Clin Lymphoma Myeloma Leuk. e-Pub 2024. PMID: 38195323.
- Strati, P, Gregory, T, Majhail, NS, Jain, N. Chimeric Antigen Receptor T-Cell Therapy for Hematologic Malignancies. JCO Oncology Practice 19(9):706-713, 2023. e-Pub 2023. PMID: 37406255.
- Jabbour E, Short NJ, Jain N, Haddad FG, Welch MA, Ravandi F, Kantarjian H. The evolution of acute lymphoblastic leukemia research and therapy at MD Anderson over four decades. J Hematol Oncol 16(1):22, 2023. e-Pub 2023. PMID: 36927623.
- Kantarjian HM, Jain N, Garcia-Manero G, Welch MA, Ravandi F, Wierda WG, Jabbour EJ. The cure of leukemia through the optimist's prism. Cancer. e-Pub 2021. PMID: 34614211.
- Cherng HJ, |Jain N. First-Line Therapy for Chronic Lymphocytic Leukemia: Bruton Tyrosine Kinase or BCL2 or Both?. Hematol Oncol Clin North Am 35(4):725-738, 2021. e-Pub 2021. PMID: 34174983.
- Thakral B, Jain N, Tang G, Konoplev S, Vega F, Medeiros LJ, Wang SA. From the archives of MD Anderson Cancer Center: Concurrent BCR-ABL1 and CRLF2 rearrangements in B-lymphoblast phase of chronic myeloid leukemia. Ann Diagn Pathol 53:151767. e-Pub 2021. PMID: 34118580.
- Paul S, Rausch CR, Jain N, Kadia T, Ravandi F, DiNardo CD, Welch MA, Dabaja BS, Daver N, Garcia-Manero G, Wierda W, Pemmaraju N, Montalban Bravo G, Thompson P, Verstovsek S, Konopleva M, Kantarjian H, Jabbour E. Treating Leukemia in the Time of COVID-19. Acta Haematol:1-13. e-Pub 2020. PMID: 32392559.
- Jain N. Selecting Frontline Therapy for CLL in 2018. Hematology Am Soc Hematol Educ Program 2018(1):242-247, 2018. e-Pub 2018. PMID: 30504317.
- Jain N, Thompson P, Ferrajoli A, Nabhan C, Mato AR, O'Brien S. Approaches to Chronic Lymphocytic Leukemia Therapy in the Era of New Agents: The Conundrum of Many Options. Am Soc Clin Oncol Educ Book(38):580-591, 2018. e-Pub 2018. PMID: 30231393.
- Neelapu SS, Tummala S, Kebriaei P, Wierda W, Gutierrez C, Locke FL, Komanduri KV, Lin Y, Jain N, Daver N, Westin J, Gulbis AM, Loghin ME, de Groot JF, Adkins S, Davis SE, Rezvani K, Hwu P, Shpall EJ. Chimeric antigen receptor T-cell therapy - assessment and management of toxicities. Nat Rev Clin Oncol. e-Pub 2017. PMID: 28925994.
- Verma D, Kantarjian H, Jain N, Cortes J. Sustained complete molecular response after imatinib discontinuation in a patient with chronic myeloid leukemia not previously exposed to interferon alpha. Leuk Lymphoma 49(7):1399-402, 2008. e-Pub 2008. PMID: 18452066.
Other Articles
Editorials
- Jain N, O'Brien S. BCR inhibitor failure in CLL: an unmet need. Blood 128(18):2193-2194, 2016. PMID: 27811187.
- Jain N, Steensma D, Stewart DJ, Kantarjian H. Insurance Denial of Coverage for Patients Enrolled in Cancer Clinical Trials Is Still a Problem in the Affordable Care Act Era. J Oncol Pract 12(4):283-5, 2016. PMID: 26907450.
- Jain N, Kantarjian H. Insurers play to win, but the patients lose. Houston Chronicle, 2015.
Book Chapters
- Afrough, A, Im, JS, Jain, N, Kebriaei, P. Chimeric Antigen Receptor T-Cell Therapy in Acute Lymphoblastic Leukemia, 233-245, 2023.
- Jain N, Bueso-Ramos C, O'Brien S, Wierda WG. Chronic Lymphocytic Leukemia and Associated Disorders. In: MD Anderson Manual of Medical Oncology. 3rd Edition. McGraw-Hill, 2016.
- Jain N, Faderl S, Kantarjian H, O'Brien S. Acute Lymphoblastic Leukemia. In: Holland-Frei Cancer Medicine. 9th Edition, 2016.
- Jain N, O'Brien S, Ravandi-Kashani F. Targeted Therapy for Acute Lymphoblastic Leukemia. In: Targeted Therapy in Translational Cancer Research (Translational Oncology). 1st Edition. Wiley-Blackwell, 2015.
- Jain N, Gurbuxani S, Rhee C, Stock W. Acute Lymphocytic Leukemia in Adults. In: Hematology: Basic Principles and Practice (Hoffman's). 6th Edition. Churchill Livingstone, 2012.
- Jain N, Verstovsek S. Philadelphia-chromosome negative myeloproliferative disorders. In: The MD Anderson Manual of Medical Oncology. 2nd Edition. McGraw-Hill Professional, 2011.
Letters to the Editor
- Swaminathan, M, DiNardo, C, Maiti, A, Pemmaraju, N, Ohanian, M, Daver, NG, Garcia-Manero, G, Issa, GC, Borthakur, G, Ravandi-Kashani, F, Montalban Bravo, G, Kadia, TM, Alvarado, Y, Jabbour, EJ, Short, NJ, Wierda, WG, Jain, N, Kornblau, SM, Masarova, L, Pierce, S, Qiao, W, Ning, J, Kantarjian, HM, Konopleva, M. VEN in combination with 10-day DEC in newly diagnosed elderly or relapsed/refractory acute myeloid leukemia, and high-risk myelodysplastic syndrome. Blood cancer journal 15, 2025.
- Zhou, T, Short, NJ, Jain, N, Patel, KP, Jabbour, EJ, Kantarjian, HM, Medeiros, LJ, Iorgulescu, JB. Age-related prognoses of genetic subtypes in B-cell acute lymphoblastic leukemia/lymphoma (B-ALL). Leukemia 39: 1769-1772, 2025.
- Senapati, J, Jabbour, EJ, Short, NJ, Jain, N, Haddad, FG, Bathala, TK, Kovalenko, I, Bidikian, A, Ravandi-Kashani, F, Khouri, IF, Kadia, TM, Garris, R, Montalban Bravo, G, Chien, KS, Shpall, E, Kebriaei, P, Kantarjian, HM. Liver elastography for risk-assessment of liver toxicity and risk factors for Sinusoidal obstruction syndrome in patients with acute lymphoblastic leukemia receiving inotuzumab ozogamicin. Blood cancer journal 14, 2024.
- Senapati, J, Jabbour, EJ, Short, NJ, Jain, N, Haddad, FG, Bathala, TK, Kovalenko, I, Bidikian, A, Ravandi-Kashani, F, Khouri, IF, Kadia, TM, Garris, R, Montalban Bravo, G, Chien, KS, Shpall, E, Kebriaei, P, Kantarjian, HM. Liver elastography for risk-assessment of liver toxicity and risk factors for Sinusoidal obstruction syndrome in patients with acute lymphoblastic leukemia receiving inotuzumab ozogamicin. Blood cancer journal 14, 2024.
- Chen Q, Jain N, Flowers CR, Chhatwal J. Reply to C. Nabhan et al. J Clin Oncol 35: 1864-1865, 2017.
Patient Reviews
CV information above last modified September 25, 2025