Pappanaicken R Kumar, PhD
Department of Hematopoietic Biology & Malignancy, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Hematopoietic Biology and Malignancy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1994 | The University of Madras, Chennai, USA, PHD, Biochemistry |
| 1990 | The University of Madras, Chennai, IND, M.Phil, Biochemistry |
Postgraduate Training
| 1996-2000 | Post-Doctoral Fellowship, Microbiology and Immunology, The University of North Texas and Health Science Center, Fort Worth, TX |
Experience & Service
Academic Appointments
Assistant Professor, Department of Lymphoma/Myeloma - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2022
Associate Professor-I (Research), Department of Biochemistry, Division of Internal Medicine, The University of California Davis School of Medicine, Sacramento, 2011 - 2012
Assistant Professor-IV (Research), The University of California Davis school of Medicine, Sacramento, 2009 - 2011
Assistant Professor-III (Research), The University of California Davis school of Medicine, Sacramento, 2007 - 2009
Assistant Professor-II (Research), Division of Internal Medicine, The University of California Davis school of Medicine, Sacramento, 2005 - 2007
Assistant Professor-I (Research), Department of Hematology/Oncology, Division of Internal Medicine, The University of California Davis School of Medicine, Sacramento, 2003 - 2005
Assistant Professor, Department of Microbiology and Immunology, Division of Immunology, The University of North Texas Health Science Center, Fort Worth, 2003 - 2008
Assistant Professor, Department of Microbiology and Immunology, Division of Immunology, The University of North Texas Health Science Center, Fort Worth, TX, 2000 - 2002
Other Appointments/Responsibilities
Assistant Professor, Medical Mycology Research Center, The UT MD Anderson Cancer Center, Houston, TX, 2018 - Present
Institutional Committee Activities
committee member, Onboarding/Exit Clearance Committee (OECC), 2018 - Present
Selected Publications
Peer-Reviewed Articles
- Kumaresan PR, da Silva TA, Kontoyiannis DP. Methods of Controlling Invasive Fungal Infections Using CD8+ T Cells. Front Immunol 8:1939, 2017. e-Pub 2018. PMID: 29358941.
- Kebriaei P, Singh H, Huls MH, Figliola MJ, Bassett R, Olivares S, Jena B, Dawson MJ, Kumaresan PR, Su S, Maiti S, Dai J, Moriarity B, Forget MA, Senyukov V, Orozco A, Liu T, McCarty J, Jackson RN, Moyes JS, Rondon G, Qazilbash M, Ciurea S, Alousi A, Nieto Y, Rezvani K, Marin D, Popat U, Hosing C, Shpall EJ, Kantarjian H, Keating M, Wierda W, Do KA, Largaespada DA, Lee DA, Hackett PB, Champlin RE, Cooper LJ. Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells. J Clin Invest 126(9):3363-76, 2016. e-Pub 2016. PMID: 27482888.
- Kumaresan P, Figliola M, Moyes JS, Huls MH, Tewari P, Shpall EJ, Champlin R, Cooper LJ. Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System. J Vis Exp(104), 2015. e-Pub 2015. PMID: 26484782.
- Krishnamurthy J, Rabinovich BA, Mi T, Switzer KC, Olivares S, Maiti SN, Plummer JB, Singh H, Kumaresan PR, Huls HM, Wang-Johanning F, Cooper LJ. Genetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on Melanoma. Clin Cancer Res 21(14):3241-51, 2015. e-Pub 2015. PMID: 25829402.
- Liu R, Shih TC, Deng X, Anwar L, Ahadi S, Kumaresan P, Lam KS. Design, synthesis, and application of OB2C combinatorial peptide and peptidomimetic libraries. Methods Mol Biol 1248:3-22, 2015. PMID: 25616322.
- Guo W, Liu R, Bhardwaj G, Yang JC, Changou C, Ma AH, Mazloom A, Chintapalli S, Xiao K, Xiao W, Kumaresan P, Sanchez E, Yeh CT, Evans CP, Patterson R, Lam KS, Kung HJ. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis 5:e1409, 2014. e-Pub 2014. PMID: 25188519.
- Kumaresan PR, Manuri PR, Albert ND, Maiti S, Singh H, Mi T, Roszik J, Rabinovich B, Olivares S, Krishnamurthy J, Zhang L, Najjar AM, Huls MH, Lee DA, Champlin RE, Kontoyiannis DP, Cooper LJ. Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection. Proc Natl Acad Sci U S A 111(29):10660-5, 2014. e-Pub 2014. PMID: 25002471.
- Kumaresan PR, Devaraj S, Huang W, Lau EY, Liu R, Lam KS, Jialal I. Synthesis and characterization of a novel inhibitor of C-reactive protein-mediated proinflammatory effects. Metab Syndr Relat Disord 11(3):177-84, 2013. e-Pub 2013. PMID: 23445482.
- Kumaresan PR, Wang Y, Saunders M, Maeda Y, Liu R, Wang X, Lam KS. Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods. ACS Comb Sci 13(3):259-64, 2011. e-Pub 2011. PMID: 21302937.
- Lee JK, Mathew SO, Vaidya SV, Kumaresan PR, Mathew PA. CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol 179(7):4672-8, 2007. PMID: 17878365.
- Kumaresan PR, Natarajan A, Song A, Wang X, Liu R, DeNardo G, DeNardo S, Lam KS. Development of tissue plasminogen activator specific "on demand cleavable" (odc) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries. Bioconjug Chem 18(1):175-82, 2007. PMID: 17226971.
- Kumaresan PR, Lam KS. Screening chemical microarrays: methods and applications. Mol Biosyst 2(5):259-70, 2006. e-Pub 2006. PMID: 16880944.
- Mathew SO, Kumaresan PR, Lee JK, Huynh VT, Mathew PA. Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells. J Immunol 175(2):1005-13, 2005. PMID: 16002700.
- Devaraj S, Kumaresan PR, Jialal I. Effect of C-reactive protein on chemokine expression in human aortic endothelial cells. J Mol Cell Cardiol 36(3):405-10, 2004. PMID: 15010279.
- Kumaresan PR, Lai WC, Chuang SS, Bennett M, Mathew PA. CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function. Mol Immunol 39(1-2):1-8, 2002. PMID: 12213321.
- Kumaresan PR, Mathew PA. Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript. Immunogenetics 51(11):987-92, 2000. PMID: 11003394.
Grant & Contract Support
| Title: | Redirected CAR T cells therapy to cure invasive fungal infections |
| Funding Source: | NIH/NIAID |
| Role: | Multi-Principal Investigator |
| Title: | Identification of Pancreatic Cancer Specific High Affinity Targeting Ligands |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Novel Targeted Immunotherapy for CML Blast cells |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Principal Investigator |
| Title: | Development of CAR-T cells for pancreatic cancer therapy |
| Funding Source: | Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research |
| Role: | Co-Investigator |
| Title: | Bi-specific CAR NK cells to control leukemia and invasive fungal infections |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Redirected CAR T cells therapy to cure invasive fungal infections |
| Funding Source: | NIH/NIAID |
| Role: | Multi-Principal Investigator |