Paul J. Chiao, Ph.D.
Department of Molecular and Cellular Oncology, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Surgical Oncology - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston
Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Education & Training
Degree-Granting Education
| 1991 | University of Texas Health Science Center, Houston, TX, USA, PHD, Cancer Biology |
| 1984 | The University of Iowa, Iowa City, IA, USA, BS, Microbiology |
Postgraduate Training
| 1991-1995 | Postdoctoral Fellow, Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA |
Honors & Awards
| 2011 | Ashbel Smith Professorship Award, The University of Texas M. D. Anderson Cancer Center |
| 1997 | Excellent Young Scientist of 1997, The Foundation of Dr. Wang, Q. C. of the Chinese Academy of Science |
| 1991 | National Institutes of Health Postdoctoral Fellowship Award, NIH |
| 1986 | American Legion Auxiliary Fellowship for Predoctoral Research Award, Graduate School of Biomedical Sciences, The University of Texas, Houston, Texas |
| 1981 | Undergraduate Scholarship, University of Iowa |
Selected Publications
Peer-Reviewed Articles
- Melisi D, Xia Q, Paradiso G, Ling J, Moccia T, Carbone C, Budillon A, Abbruzzese JL, Chiao PJ. Modulation of pancreatic cancer chemoresistance by inhibition of TAK1. J Natl Cancer Inst 103(15):1190-204, 2011. e-Pub 2011. PMID: 21743023.
- Peng B, Lee, AJ, Wang Z, Ling J, Jin W, Yang K, Zhang R, Chang Z, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's Syndrome in the mice with mutated kappaB enhancers of the lkappaBalpha promoter. Proc Natl Acad Sci USA 107(34):15193-15198, 2010. PMID: 20696914.
Grant & Contract Support
| Title: | The mechanisms of tumorigenesis of pancreatic epithelial cells |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Mechanism of constitutive RelA activation in Pancreas Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | The function and clinical significance of DPC4 tumor suppressor gene in cancer |
| Funding Source: | ATP/ARP |
| Role: | Principal Investigator |
| Title: | Regulation of MAP kinase signaling in carcer progression and metastasis |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Transgenic/knockout mouse model for pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator-MDACC |
| Title: | Mechanisms of overexpressed TrkB in inducing pancreatic cancer metastasis |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | The role of RelA in human adenocarcinoma of pancreas |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Mechanism of constitutive RelA activation in Pancreas Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Validation of potential early diagnostic and prognostic markers for pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | The function of NF-kappaB in Cancer Metastasis |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | The function and clinical significance of DPC4 tumor suppressor gene in cancer |
| Funding Source: | Texas Higher Education Orrdinating Board Advanced Technology Program (ATP/ARP) |
| Role: | Principal Investigator |
| Title: | Restoration of apoptosis in cancer |
| Funding Source: | NIH/NCI |
| Role: | Project Leader |
| Title: | NF-kappaB signaling pathways in pancreatic cancer biology and therapy |
| Funding Source: | NIH/NCI |
| Role: | Project Leader |
| Title: | Function and Regulation Mechanisms of Polo-like Kinase 3 in Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Global Profiling of Ubiquitination in the NF-kappaB Pathway for Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | TAK1 is a novel therapeutic target in pancreatic cancer |
| Funding Source: | Pancreatic Cancer Action Network-AACR |
| Role: | Principal Investigator |
| Title: | A SYSTEMATIC RNA INTERFERENCE STRATEGY FOR IDENTIFYING KINASES AS SYNTHETIC LETHAL PARTNERS TO TARGET ONCOGENIC KRAS/TAK1 SIGNALING AXIS IN PANCREATIC CANCER |
| Funding Source: | Viragh Foundation |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified December 08, 2023