Pratip K. Bhattacharya, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
About Dr. Bhattacharya
The focus of research in Dr. Bhattacharya's laboratory in the Department of Cancer Systems Imaging is the development of real-time metabolic and imaging applications by hyperpolarization. We are exploring novel ways to utilize Magnetic Resonance Imaging (MRI) to create more detailed metabolic and molecular imaging studies by employing hyperpolarized, non-radioactive carbon 13 (13C) and nitrogen 15 (15N)-labeled compounds and silicon particles and nanoparticles (SiNPs) to tag specific metabolic and biochemical structures and functions that are altered in cancer. Hyperpolarized MR is a non-toxic, non-radioactive method for non-invasively assessing tissue metabolism and other physiologic properties. Hyperpolarization allows for a >10,000-fold signal enhancement relative to conventional MRI or MRS. After hyperpolarization, the signal enhancement can be retained on the metabolites of the hyperpolarized molecules for several minutes. Dr. Bhattacharya’s, lab is working on techniques to extend this relaxation time so that more detailed metabolic and molecular imaging studies can be considered.
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Magnetic Resonance laboratory is involved in three primary areas of research:
· Real time metabolic MR imaging with hyperpolarized 13C and 15N labeled non-radioactive compounds. The goal of this research is to use mostly endogenous compounds to track different metabolic pathways in vivo in real time both in preclinical animal models and in human applications.
· Real-time molecular MR imaging with hyperpolarized silicon nanoparticle (SiNPs) functionalized to target specific biological functions and structure. Hyperpolarized SiNPs have opened the door for targeted functional imaging by MR that used to be in the realm of PET and SPECT. Due to the simple surface chemistry, the hyperpolarized SiNPs can serve as a nanoplatform, allowing a variety of targeting agents and potentially therapeutic drugs to be loaded onto the particles, which enables real-time targeted Theranostics imaging studies with an imaging time window of roughly one hour.
· High resolution MR metabolomics of animal and human tissues. To complement the real-time in vivo hyperpolarization studies, we have developed an MR based metabolomics program to generate comprehensive metabolic profiles of cancerous and non-cancerous tissues in vitro.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Graduate Faculty, Division of Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX
Associate Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2005 | California Institute of Technology, Pasadena, CA, USA, PHD, Chemistry, Prof. Jacqueline K. Barton |
Postgraduate Training
| 2005-2006 | James G. Boswell Fellowship, MR Physics, Huntington Medical Research Institutes/Caltech, Pasadena, CA |
Experience & Service
Academic Appointments
Associate Professor, Department of Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2013
Assistant Professor, Division of Huntington Medical Research Institutes, Keck School of Medicine, University of Southern California, Los Angeles, CA, 2006 - 2012
Other Appointments/Responsibilities
James G. Boswell Fellow, California Institute of Technology & MR Unit, Huntington Medical Research Institutes, Pasadena, CA, 2004 - 2006
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Salzillo TC, Mawoneke V, Weygand J, Shetty A, Gumin J, Zacharias NM, Gammon ST, Piwnica-Worms D, Fuller GN, Logothetis CJ, Lang FF, Bhattacharya PK. Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance. Cells 10(10):2621, 2021. e-Pub 2021. PMID: 34685601.
- Ramezani S, Parkhideh A, Bhattacharya PK, Farach-Carson MC, Harrington DA. Beyond Colonoscopy: Exploring New Cell Surface Biomarkers for Detection of Early, Heterogenous Colorectal Lesions. Front Oncol 10(10):2621, 2021. e-Pub 2021. PMID: 34290978.
- Zhang Y, Chandra V, Riquelme Sanchez E, Dutta P, Quesada PR, Rakoski A, Zoltan M, Arora N, Baydogan S, Horne W, Burks J, Xu H, Hussain P, Wang H, Gupta S, Maitra A, Bailey JM, Moghaddam SJ, Banerjee S, Sahin I, Bhattacharya PK, McAllister F. Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 217(12):e20190354, 2020. PMID: 32860704.
- Jaiswal AR, Liu AJ, Pudakalakatti S, Dutta P, Jayaprakash P, Bartkowiak T, Ager CR, Wang ZQ, Reuben A, Cooper ZA, Ivan C, Ju Z, Nwajei F, Wang J, Davies MA, Davis RE, Wargo JA, Bhattacharya PK, Hong DS, Curran MA. Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype. Cancer Immunol Res 8(11):1365-1380, 2020. e-Pub 2020. PMID: 32917656.
- Dutta P, Pando SC, Mascaro M, Riquelme E, Zoltan M, Zacharias NM, Gammon ST, Piwnica-Worms D, Pagel MD, Sen S, Maitra A, Shams S, McAllister F, Bhattacharya PK. Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy. Int J Mol Sci 21(10):3722, 2020. e-Pub 2020. PMID: 32466260.
- Zacharias NM, Baran N, Shanmugavelandy SS, Lee J, Lujan JV, Dutta P, Millward SW, Cai T, Wood CG, Piwnica-Worms D, Konopleva M, Bhattacharya PK. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia. Mol Cancer Ther 18(11):1937-1946, 2019. e-Pub 2019. PMID: 31387889.
- Dutta P, Perez MR, Lee J, Kang Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PK. Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer. J Proteome Res 18(7):2826-2834, 2019. e-Pub 2019. PMID: 31120258.
- Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM, Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4), 2019. e-Pub 2019. PMID: 30978984.
- Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW. Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy. Angew Chem Int Ed Engl 58(13):4179-4183, 2019. e-Pub 2019. PMID: 30680862.
- Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA, Bhattacharya P. Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Mol Imaging Biol 21(1):86-94, 2019. PMID: 29748904.
- Seo H, Choi I, Whiting N, Hu J, Luu QS, Pudakalakatti S, McCowan C, Kim Y, Zacharias N, Lee S, Bhattacharya P, Lee Y. Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29 Si Magnetic Resonance Imaging. Chemphyschem 19(17):2143-2147, 2018. e-Pub 2018. PMID: 29779258.
- Hövener JB, Pravdivtsev AN, Kidd B, Bowers CR, Glöggler S, Kovtunov KV, Plaumann M, Katz-Brull R, Buckenmaier K, Jerschow A, Reineri F, Theis T, Shchepin RV, Wagner S, Bhattacharya P, Zacharias NM, Chekmenev EY. Parahydrogen-Based Hyperpolarization for Biomedicine. Angew Chem Int Ed Engl 57(35):11140-11162, 2018. e-Pub 2018. PMID: 29484795.
- Zacharias NM, McCullough C, Shanmugavelandy S, Lee J, Lee Y, Dutta P, McHenry J, Nguyen L, Norton W, Jones LW, Bhattacharya PK. Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer. Sci Rep 7(1):16159, 2017. e-Pub 2017. PMID: 29170516.
- Ornelas A, Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Vilar E, Bhattacharya P, Millward S. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev 36(2):289-303. e-Pub 2017. PMID: 28762014.
- Hu J, Salzillo TC, Sailasuta N, Lang FF, Bhattacharya PK. Interrogating IDH Mutation in Brain Tumor: Magnetic Resonance and Hyperpolarization. Top Magn Reson Imaging 26(1):27-32, 2017. PMID: 28079713.
- Salzillo TC, Hu J, Nguyen L, Whiting N, Lee J, Weygand J, Dutta P, Pudakalakatti S, Millward NZ, Gammon ST, Lang FF, Heimberger AB, Bhattacharya PK. Interrogating Metabolism in Brain Cancer. Magn Reson Imaging Clin N Am 24(4):687-703, 2016. PMID: 27742110.
- Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC, Millward SW. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16(1):824, 2016. e-Pub 2016. PMID: 27784287.
- Whiting N, Hu J, Zacharias NM, Lokesh GL, Volk DE, Menter DG, Rupaimoole R, Previs R, Sood AK, Bhattacharya P. Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. J Med Imaging (Bellingham) 3(3):036001, 2016. e-Pub 2016. PMID: 27547777.
- Zacharias NM, McCullough CR, Wagner S, Sailasuta N, Chan HR, Lee Y, Hu J, Perman WH, Henneberg C, Ross BD, Bhattacharya P. Towards Real-time Metabolic Profiling of Cancer with Hyperpolarized Succinate. J Mol Imaging Dyn 6(1), 2016. e-Pub 2016. PMID: 27547490.
- Benito J, Ramirez MS, Millward NZ, Velez J, Harutyunyan KG, Lu H, Shi YX, Matre P, Jacamo R, Ma H, Konoplev S, McQueen T, Volgin A, Protopopova M, Mu H, Lee J, Bhattacharya PK, Marszalek JR, Davis RE, Bankson JA, Cortes JE, Hart CP, Andreeff M, Konopleva M. Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in pre-clinical leukemia models. Clin Cancer Res 22(7):1687-98, 2016. e-Pub 2015. PMID: 26603259.
- Jeong G, Lee JW, Gong G, Ko H, Choi I, Seo H, Lee Y, Zacharias Millward NM, Bhattacharya PK. Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo. Journal of Industrial and Engineering Chemistry 36:224-228, 2016. e-Pub 2016.
- Zand B, Previs RA, Zacharias NM, Rupaimoole R, Mitamura T, Nagaraja AS, Guindani M, Dalton HJ, Yang L, Baddour J, Achreja A, Hu W, Pecot CV, Ivan C, Wu SY, McCullough CR, Gharpure KM, Shoshan E, Pradeep S, Mangala LS, Rodriguez-Aguayo C, Wang Y, Nick AM, Davies MA, Armaiz-Pena G, Liu J, Lutgendorf SK, Baggerly KA, Eli MB, Lopez-Berestein G, Nagrath D, Bhattacharya PK, Sood AK. Role of increased n-acetylaspartate levels in cancer. J Natl Cancer Inst 108(6):djv426, 2016. e-Pub 2016. PMID: 26819345.
- Rupaimoole R, Lee J, Haemmerle M, Ling H, Previs RA, Pradeep S, Wu SY, Ivan C, Ferracin M, Dennison JB, Millward NM, Nagaraja AS, Gharpure KM, McGuire M, Sam N, Armaiz-Pena GN, Sadaoui NC, Rodriguez-Aguayo C, Calin GA, Drapkin RI, Kovacs J, Mills GB, Zhang W, Lopez-Berestein G, Bhattacharya PK, Sood AK. Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Rep 13(11):2395-402, 2015. e-Pub 2015. PMID: 26686630.
- Lai SY, Fuller CD, Bhattacharya PK, Frank SJ. Metabolic Imaging as a Biomarker of Early Radiation Response in Tumors. Clin Cancer Res 21(22):4996-8, 2015. e-Pub 2015. PMID: 26232369.
- Whiting N, Hu J, Shah JV, Cassidy MC, Cressman E, Millward NZ, Menter DG, Marcus CM, Bhattacharya PK. Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles. Sci Rep 5:12842, 2015. e-Pub 2015. PMID: 26239953.
- Lee Y, Zacharias N, Piwnica-worms D, Bhattacharya PK. Chemical Reaction-Induced Multi-molecular Polarization (CRIMP). Chemical Communications 50 50(86):13030-3, 2014. PMID: 25224323.
- Cassidy MC, Chan HR, Ross BD, Bhattacharya PK, Marcus CM. In vivo magnetic resonance imaging of hyperpolarized silicon particles. Nat Nanotechnol 8(5):363-8, 2013. e-Pub 2013. PMID: 23644571.
- Zacharias NM, Chan HR, Sailasuta N, Ross BD, Bhattacharya PK. Real-Time Molecular Imaging of Tricarboxylic Acid Cycle Metabolism. Journal of the American Chemical Society 134(2):934-943, 2012. PMID: 22146049.
- Lingwood MD, Siaw TA, Sailasuta N, Abulseoud OA, Chan HR, Ross BD, Bhattacharya PK, Han S. Hyperpolarized Water as an MR Imaging Contrast Agent: Feasibility of in Vivo Imaging in a Rat Model. Radiology 265(2):418-425, 2012. e-Pub 2012. PMID: 22996746.
- Bhattacharya PK, Chekmenev E, Reynolds WF, Wagner S, Zacharias N, Chan HR, Bunger R, Ross BD. PHIP Hyperpolarized MR Receptor Imaging In Vivo: A Pilot Study of 13C Imaging of Atheroma in Mice. NMR in Biomedicine 24(Special Issue Research Article):1023-1028, 2011. e-Pub 2011. PMID: 21538638.
- Ross B, Tran T, Bhattacharya PK, Watterson DM, Sailasuta N. Application of NMR Spectroscopy in Medicinal Chemistry and Drug Discovery. Current Topics in Medicinal Chemistry 11(1):93-114, 2011. PMID: 20809893.
- Lingwood MD, Siaw TA, Sailasuta N, Ross BD, Bhattacharya PK, Han S. Continuous flow Overhauser dynamic nuclear polarization of water in the fringe field of a clinical magnetic resonance imaging system for authentic image contrast. J Magn Reson 205(2):247-254, 2010. e-Pub 2010. PMID: 20541445.
- Perman WH, Bhattacharya PK, Leupold J, Lin AP, Harris KC, Norton VA, Hovener JB, Ross BD. Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP. Magnetic Resonance Imaging 28(4):459-465, 2010. PMID: 20171034.
- Ross BD, Bhattacharya PK, Wagner S, Tran T, Sailasuta N. Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism. AJNR Am J Neuroradiol 31(1):24-33, 2010. e-Pub 2009. PMID: 19875468.
- Bhattacharya PK, Ross BD, Bünger R. Cardiovascular Applications of Hyperpolarized Contrast Media and Metabolic Tracers. Exp Biol Med (Maywood) 234(12):1395-1416, 2009. PMID: 19934362.
- Chekmenev EY, Norton VA, Weitekamp DP, Bhattacharya PK. Hyperpolarized 1H NMR Employing Low γ Nucleus for Spin Polarization Storage. J Am Chem Soc 131(9):3164-3165, 2009. PMID: 19256566.
- Hovener J-B, Chekmenev EY, Harris KC, Perman WH, Tran TT, Ross BD, Bhattacharya PK. Quality assurance of PASADENA hyperpolarization for. MAGMA-Magnetic Resonance Materials in Physics, Biology and Medicine 22(2):123-134, 2009. PMID: 19067009.
- Hovener JB, Chekmenev EY, Harris KC, Perman WH, Robertson LW, Ross BD, Bhattacharya PK. PASADENA Hyperpolarization of 13C Biomolecules: Equipment Design and Installation. MAGMA-Magnetic Resonance Materials in Physics, Biology and Medicine 22(2):111-121, 2009. PMID: 19067008.
- Chekmenev EY, Hövener J, Norton VA, Harris K, Batchelder LS, Bhattacharya PK, Ross BD, Weitekamp DP. PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy. J Am Chem Soc 130(13):4212-3, 2008. e-Pub 2008. PMID: 18335934.
- Chekmenev EY, Chow S-K, Tofan D, Weitekamp DP, Ross BD, Bhattacharya PK. Fluorine-19 NMR Chemical Shift Probes Molecular Binding to Lipid Membranes. The Journal of Physical Chemistry B 112(20):6285-6287, 2008. PMID: 18422359.
- Bhattacharya PK, Chekmenev EY, Harris KC, Perman WH, Li AP, Norton VA, Chow CT, Ross BD, Weitekamp DP. Towards Hyperpolarized (13)C-succinate Imaging of Brain Cancer. J Magn Reson 186(1):150-155, 2007.
- Bhattcharya PK, Harris K, Lin AP, Mansson M, Norton VA, Perman WH, Weitekamp DP, Ross BD. Ultra-fast Three Dimensional Imaging of Hyperpolarized 13C In Vivo. Biology and Medicine Magnetic Resonance Materials in Physics 18(5):245-256, 2005.
- Bhattacharya PK, Lawson HJ, Barton JK. 1H NMR Studies of Nickel(II) Complexes Bound to Oligonucleotides: A Novel Technique for Distinguishing the Binding Locations of Metal Complexes in DNA. Inorg Chem 42(26):8811-8817, 2003. PMID: 14686861.
- Ross B, Lin A, Harris K, Bhattacharya PK, Schweinsburg B. Clinical experience with 13C MRS in vivo. NMR in Biomedicine 16(6-7):358-369, 2003. PMID: 14679500.
- Bhattacharya PK, Cha J, Barton JK. 1H NMR determination of base-pair lifetimes in oligonucleotides containing single base mismatches. Nucleic Acids Res 30(21):4740-50, 2002. PMID: 12409465.
- Delaney S, Pascaly M, Bhattacharya PK, Han K, Barton JK. Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalation. Inorg Chem 41(7):1966-74, 2002. PMID: 11925195.
- Bhattacharya PK, Barton JK. Influence of Intervening Mismatches on Long-Range Guanine Oxidation in DNA Duplexes. J Am Chem Soc 123(36):8649-8656, 2001. PMID: 11535068.
Invited Articles
- Pudakalakatti S, Enriquez JS, McCowan C, Ramezani S, Davis JS, Zacharias NM, Bourgeois D, Constantinou PE, Harrington DA, Carson D, Farach-Carson MC, Bhattacharya PK. Hyperpolarized MRI with silicon micro and nanoparticles: Principles and applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13(6):e1722. e-Pub 2021. PMID: 33982426.
- Hu J, Whiting N, Constantinou PE, Farach-Carson MC, Carson DD, Bhattacharya PK. Real-time Molecular MRI with Hyperpolarized Silicon Particles, "Characterization Tools for Nanoscience & Nanotechnology". Springer.
Abstracts
- Zacharias NM, Baran N, Shanmugavelandy SS, Lee J, Velez Lujan J, Dutta P, Millward SW, Cai T, Wood CG, Piwnica-Worms D, Konopleva M, Bhattacharya PK. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia, 2019.
- Dutta P, Perez MR, Lee J, Kand Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PB. Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy to Identify Metabolic Biomarkers in Pancreatic Cancer, 2019.
- Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM, Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4), 2019. e-Pub 2019. PMID: 30978984.
- Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW. Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy. Angew Chem Int Ed Engl 58(13):4179-4183, 2019. e-Pub 2019. PMID: 30680862.
Book Chapters
- Hu J, Salzillo TC, Sailasuta N, Lang FF, Bhattacharya PK. Interrogating IDH Mutation in Brain Tumor: Magnetic Resonance and Hyperpolarization. In: Top Magn Reson Imaging. Top Magn Reson Imaging, 2017.
Patient Reviews
CV information above last modified August 21, 2024