Qing Ma, Ph.D.
Department of Hematopoietic Biology & Malignancy, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Professor, Department of Hematopoietic Biology and Malignancy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
Member, Immunology Program, University of Texas Graduate School of Biomedical Sciences at Houston (GSBS), Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1995 | Thomas Jefferson University, Philadelphia, PA, USA, PHD, Genetics |
| 1988 | Fudan University, Shanghai, CHN, BS, Biochemistry |
Postgraduate Training
| 2001-2002 | Research Fellowship, Transplantation, Fred Hutchinson Cancer Research Center, Seattle, WA |
| 1995-2001 | Research Fellowship, Immunology, Harvard Medical School, Boston, MA |
Experience & Service
Academic Appointments
Associate Professor, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2019
Assistant Professor, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 2003 - 2010
Other Appointments/Responsibilities
Member, GSBS Academic Standards Committee, Houston, TX, 2018 - 2021
Member, GSBS Curriculum Committee, Houston, TX, 2009 - 2011
Member, GSBS Executive Committee, Houston, TX, 2008 - 2009
Member, Center for Inflammation and Cancer, University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - Present
Member, GSBS Student Affairs Committee, Houston, TX, 2006 - 2009
Member, Center for Cancer Immunology Research, Houston, TX, 2003 - Present
Institutional Committee Activities
Member, Graduate Education Committee, 2013 - 2018
Member, Study Section Review Committee for the Institutional Research Grants (IRG), 2013 - Present
Member, Institutional Animal Care and Use Committee (IACUC), 2007 - 2011
Selected Publications
Peer-Reviewed Articles
- Ma Q, Li D, Vasquez HG, You MJ, Afshar-Kharghan V. Kidney Injury in Murine Models of Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 25(10):1920-1924, 2019. e-Pub 2019. PMID: 31271886.
- Al Malki MM, Jones R, Ma Q, Lee D, Reisner Y, Miller JS, Lang P, Hongeng S, Hari P, Strober S, Yu J, Maziarz R, Mavilio D, Roy DC, Bonini C, Champlin RE, Fuchs EJ, Ciurea SO. Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016. Biol Blood Marrow Transplant 24(5):895-908, 2018. e-Pub 2018. PMID: 29339270.
- Ma Q, Zhou D, DeLyria ES, Wen X, Lu W, Thapa P, Liu C, Li D, Bassett RL, Overwijk WW, Hwu P, Li C. Synthetic poly(L-glutamic acid)-conjugated CpG exhibits antitumor efficacy with increased retention in tumor and draining lymph nodes after intratumoral injection in a mouse model of melanoma. J Immunother 40(1):11-20, 2017. e-Pub 2016. PMID: 27681378.
- Ma Q, Garber HR, Lu S, He H, Tallis E, Ding X, Sergeeva A, Wood MS, Dotti G, Salvado B, Ruisaard K, Clise-Dwyer K, John LS, Rezvani K, Alatrash G, Shpall EJ, Molldrem JJ. A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells. Cytotherapy 18(8):985-94, 2016. e-Pub 2016. PMID: 27265873.
- Sergeeva A, He H, Ruisaard K, St John L, Alatrash G, Clise-Dwyer K, Li D, Patenia R, Hong R, Sukhumalchandra P, You MJ, Gagea M, Ma Q, Molldrem JJ. Activity of 8F4, a T cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo. Leukemia 30(7):1475-84, 2016. e-Pub 2016. PMID: 27055866.
- Li D, Patenia R, Bassett R, Zweidler-McKay P, Alousi AM, Champlin RE, Molldrem JJ, Mak TW, Ma Q. 2-Methoxyestradiol Treatment Prevents Graft-versus-Host Disease While Preserving Graft-versus-Leukemia Effect in Mice. Biol Blood Marrow Transplant 22(3):S405-406, 2016.
- Ciurea SO, Thall PF, Milton DR, Barnes TH, Kongtim P, Carmazzi Y, López AA, Yap DY, Popat U, Rondon G, Lichtiger B, Aung F, Afshar-Kharghan V, Ma Q, Fernández-Viña M, Champlin RE, Cao K. Complement-binding Donor-specific Anti-HLA Antibodies and Risk of Primary Graft Failure in Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 21(8):1392-8, 2015. e-Pub 2015. PMID: 25985919.
- Li D, Patenia BS, Bassett R, Tetz G, Champlin RE, Ma Q. DNase I Treatment Reduces GVHD in Mice. Biol Blood Marrow Transplant 21(2):S339, 2015.
- Ma Q, Li D, Carreño R, Patenia R, Tsai KY, Xydes-Smith M, Alousi AM, Champlin RE, Sale GE, Afshar-Kharghan V. Complement component C3 mediates Th1/Th17 polarization in human T-cell activation and cutaneous GVHD. Bone Marrow Transplant 49(7):972-6, 2014. e-Pub 2014. PMID: 24777193.
- Ma Q, Li D, Nurieva R, Patenia R, Bassett R, Cao W, Alekseev AM, He H, Molldrem JJ, Kroll MH, Champlin RE, Sale GE, Afshar-Kharghan V. Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation. Biol Blood Marrow Transplant 18(8):1174-81, 2012. e-Pub 2012. PMID: 22664751.
- Sergeeva A, Alatrash G, He H, Ruisaard K, Lu S, Wygant J, McIntyre BW, Ma Q, Li D, St John L, Clise-Dwyer K, Molldrem JJ. An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells. Blood 117(16):4262-72, 2011. e-Pub 2011. PMID: 21296998.
- Ma Q, Wang C, Jones D, Quintanilla KE, Li D, Wang Y, Wieder ED, Clise-Dwyer K, Alatrash G, Mj Y, Munsell MF, Lu S, Qazilbash MH, Molldrem JJ. Adoptive transfer of PR1 cytotoxic T lymphocytes associated with reduced leukemia burden in a mouse acute myeloid leukemia xenograft model. Cytotherapy 12(8):1056-62, 2010. e-Pub 2010. PMID: 20735170.
- Li D, Li Y, Hernandez JA, Patenia R, Kim TK, Khalili J, Dougherty MC, Hanley PJ, Bollard CM, Komanduri KV, Hwu P, Champlin RE, Radvanyi LG, Molldrem JJ, Ma Q. Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs. J Immunother 33(9):975-82, 2010. PMID: 20948439.
- Carreño R, Brown WS, Li D, Hernandez JA, Wang Y, Kim TK, Craft JW, Komanduri KV, Radvanyi LG, Hwu P, Molldrem JJ, Legge GB, McIntyre BW, Ma Q. 2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1. J Biol Chem 285(43):32860-8, 2010. e-Pub 2010. PMID: 20724473.
- Palmer LA, Sale GE, Balogun JI, Li D, Jones D, Molldrem JJ, Storb RF, Ma Q. Chemokine receptor CCR5 mediates alloimmune responses in graft-versus-host disease. Biol Blood Marrow Transplant 16(3):311-9, 2010. e-Pub 2009. PMID: 20025985.
- Wang Y, Li D, Jones D, Bassett R, Sale GE, Khalili J, Komanduri KV, Couriel DR, Champlin RE, Molldrem JJ, Ma Q. Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation. Biol Blood Marrow Transplant 15(12):1513-22, 2009. e-Pub 2009. PMID: 19896074.
- Kim TK, St John LS, Wieder ED, Khalili J, Ma Q, Komanduri KV. Human late memory CD8+ T cells have a distinct cytokine signature characterized by CC chemokine production without IL-2 production. J Immunol 183(10):6167-74, 2009. e-Pub 2009. PMID: 19841187.
- Li D, Molldrem JJ, Ma Q. LFA-1 Regulates CD8+ T Cell Activation via T Cell Receptor-mediated and LFA-1-mediated Erk1/2 Signal Pathways. J Biol Chem 284(31):21001-10, 2009. e-Pub 2009. PMID: 19483086.
- Ma Q, Gooley TA, Storb RF. CCR5 expression on cells from HLA-matched unrelated marrow donors and graft-versus-host disease. Biol Blood Marrow Transplant 16:132-133, 2009. PMID: 20053336.
- Wang Y, Li D, Nurieva R, Yang J, Sen M, Carreño R, Lu S, McIntyre BW, Molldrem JJ, Legge GB, Ma Q. LFA-1 affinity regulation is necessary for the activation and proliferation of naïve T cells. J Biol Chem 284(19):12645-53, 2009. e-Pub 2009. PMID: 19297325.
- Carreño R, Li D, Sen M, Nira I, Yamakawa T, Ma Q, Legge GB. A mechanism for antibody-mediated outside-in activation of LFA-1. J Biol Chem 283(16):10642-48, 2008. e-Pub 2008. PMID: 18199751.
- Lu S, Wieder E, Komanduri K, Ma Q, Molldrem JJ. Vaccines in Leukemia. Adv Pharmacol 51:255-70, 2004. PMID: 15464913.
- Ma Q, Shimaoka M, Lu C, Jing H, Carman CV, Springer TA. Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem 277(12):10638-41, 2002. e-Pub 2002. PMID: 11792712.
- Ma Q, Jones D, Springer TA. The chemokine receptor CXCR4 is required for the retention of B-lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 10(4):463-71, 1999. PMID: 10229189.
- Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA. Impaired B-lymphopoiesis, myelopiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95(16):9448-53, 1998. PMID: 9689100.
- Ma Q, Alder H, Nelson KK, Chatterjee D, Gu Y, Nakamura T, Canaani E, Croce, C,M, Siracusa LD, Buchberg AM. Analysis of the murine ALLl-1gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. Proc Natl Acad Sci USA 9(13):6350-4, 1993. PMID: 8327517.
Grant & Contract Support
| Title: | LFA-1 Affininty Regulation and T Cell Mediated Alloimmunity |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Principal Investigator |
| Title: | Mechanism of Posttransplant Thrombotic Microangiopathy |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Principal Investigator |
| Title: | Improving cord blood transplantation |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | An Anti-PR1/HLA-A2 Antibody as Novel Therapy for Myeloid Malignancies |
| Funding Source: | Leukemia and Lymphoma Society |
| Role: | Co-Principal Investigator |
| Title: | The role of complement system in alloimmune responses |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | UT M.D. Anderson Cancer Center SPORE-Leukemia |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Investigation of ex vivo fucosylation to enhance the efficacy of adoptive T cell immunotherapy |
| Funding Source: | Leukemia and Lymphoma Society |
| Role: | Co-Investigator |
| Title: | Genetics of graft versus host disease |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | The interaction between the complement system and VWF after bone marrow transplant |
| Funding Source: | American Society of Hematology Bridge Fund |
| Role: | Collaborator |
| Title: | COVID-19: A Study to Collect Peripheral Blood, Tissue and Bone Marrow Samples from Donors and Receipients of Blood and Marrow Transplants for Laboratory Research |
| Funding Source: | Tranquil Clinical and Research |
| Role: | Principal Investigator |
| Title: | Effect of SIRP alpha mismatch on the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) ) from an HLA matched related donor R03 CA232444-01 |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
Patient Reviews
CV information above last modified April 15, 2024