
Ravin Ratan, MD, M.Ed.
Department of Sarcoma Medical Oncology, Division of Cancer Medicine
In the News
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
2015 | University of Houston, Houston, TX, USA, ME, Education/Health Science |
2009 | Tufts University School of Medicine, Boston, MA, USA, MD, Medicine |
2005 | Trinity College, Hartford, CT, USA, BS, Science/Biology |
Postgraduate Training
2014-2015 | Chief Fellow, Fellow Education, University of Texas MD Anderson Cancer Center, Houston, TX |
2013-2014 | Chief Fellow, Resident Education, University of Texas MD Anderson Cancer Center, Houston, TX |
2012-2013 | Clinical Fellowship, Hematology and Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX |
2009-2012 | Clinical Residency, Internal Medicine, New York-Presbyterian Weill Cornell Medical Center, New York, NY |
Board Certifications
2015 | American Board of Internal Medicine-Medical Oncology |
2015 | American Board of Internal Medicine-Hematology |
2012 | American Board of Internal Medicine-Internal Medicine |
Experience & Service
Academic Appointments
Assistant Professor, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2021
Other Appointments/Responsibilities
OneConnect SuperUser, MD Anderson Cancer Center, Houston, TX, 2016 - 2018
Institutional Committee Activities
Member, Fellowship Steering Committee, 2013 - Present
Internal Medical Representative, New York Presbyterian Weill Cornell Graduate Medical Education Committee, 2010 - 2012
President, New York Presbyterian Weill Cornell Internal Medicine Housestaff Committee, 2009 - 2012
Member, Tufts University School of Medicine Admissions Committee, 2008 - 2009
Honors & Awards
2012 | David B. Skinner M.D. Award, Weill Cornell Medical College |
2009 | Dr. Frank Inserra Prize, Tufts University School of Medicine |
2008 | Alpha Omega Alpha Medical Honor Society, Tufts University School of Medicine |
Selected Publications
Peer-Reviewed Articles
- Moyers JT, Pestana RC, Roszik J, Hong DS, Naing A, Fu S, Piha-Paul S, Yap TA, Karp D, Rodon J, Livingston A, Zarzour MA, Ravi V, Patel S, Benjamin RS, Ludwig J, Herzog C, Ratan R, Somaiah N, Conley A, Gorlick R, Meric-Bernstam F, Subbiah V. Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102). Clin Cancer Res 29(2):401-409, 2023. e-Pub 2022. PMID: 36288393.
- Hinchcliff E, Rumpf J, Ratan R, Fleming ND, Jazaeri A, Fellman B, Meyer L, Soliman P. Hormone receptor status and the role of oophorectomy in uterine leiomyosarcoma. Gynecol Oncol 167(3):490-495, 2022. e-Pub 2022. PMID: 36270831.
- Guadagnolo BA, Bassett RL, Mitra D, Farooqi A, Hempel C, Dorber C, Willis T, Wang WL, Ratan R, Somaiah N, Benjamin RS, Torres KE, Hunt KK, Scally CP, Keung EZ, Satcher RL, Bird JE, Lin PP, Moon BS, Lewis VO, Roland CL, Bishop AJ. Hypofractionated, 3-week, preoperative radiotherapy for patients with soft tissue sarcomas (HYPORT-STS): a single-centre, open-label, single-arm, phase 2 trial. Lancet Oncol 23(12):1547-1557, 2022. e-Pub 2022. PMID: 36343656.
- Nathenson MJ, Hu J, Ratan R, Somaiah N, Hsu R, DeMaria PJ, Catoe HW, Pang A, Subhawong TK, Amini B, Sweet K, Feister K, Malik K, Jagannathan J, Braschi-Amirfarzan M, Sheren J, Caldas Y, Moreno Tellez C, Rosenberg AE, Lazar AJ, Maki RG, Benedetto P, Cohen J, Trent JC, Ravi V, Patel S, Wilky BA. Systemic chemotherapies retain anti-tumor activity in desmoid tumors independent of specific mutations in CTNNB1 or APC: A multi-institutional retrospective study. Clin Cancer Res 28(18):4092-4104, 2022. e-Pub 2022. PMID: 35180772.
- Thirasastr P, Lin H, Amini B, Wang WL, Cloutier JM, Nassif EF, Keung EZ, Roland CL, Feig B, Araujo D, Benjamin RS, Conley AP, Livingston JA, Ludwig J, Patel S, Ratan R, Ravi V, Zarzour MA, Zhou X, Somaiah N. Retrospective evaluation of the role of gemcitabine-docetaxel in well-differentiated and dedifferentiated liposarcoma. Cancer Med. e-Pub 2022. PMID: 36151848.
- Subbiah V, Braña I, Longhi A, Boni V, Delord JP, Awada A, Boudou-Rouquette P, Sarantopoulos J, Shapiro GI, Elias A, Ratan R, Fernandez C, Kahatt C, Cullell-Young M, Siguero M, Zeaiter A, Chawla SP. Antitumor Activity of Lurbinectedin, a Selective Inhibitor of Oncogene Transcription, in Relapsed Ewing Sarcoma: Results of a Basket Phase II Study. Clin Cancer Res 28(13):2762-2770, 2022. e-Pub 2022. PMID: 35486638.
- Lamhamedi-Cherradi SE, Maitituoheti M, Menegaz BA, Krishnan S, Vetter AM, Camacho P, Wu CC, Beird HC, Porter RW, Ingram DR, Ramamoorthy V, Mohiuddin S, McCall D, Truong DD, Cuglievan B, Futreal PA, Velasco AR, Anvar NE, Utama B, Titus M, Lazar AJ, Wang WL, Rodriguez-Aguayo C, Ratan R, Livingston JA, Rai K, MacLeod AR, Daw NC, Hayes-Jordan A, Ludwig JA. The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma. Nat Commun 13(1):3057, 2022. e-Pub 2022. PMID: 35650195.
- Boyce-Fappiano D, Damron EP, Farooqi A, Mitra D, Conley AP, Somaiah N, Araujo DM, Livingston JA, Ratan R, Keung EZ, Roland CL, Guadagnolo BA, Bishop AJ. Hypofractionated Radiation Therapy for Unresectable or Metastatic Sarcoma Lesions. Adv Radiat Oncol 7(3):100913, 2022. e-Pub 2022. PMID: 35647398.
- Lazcano R, Barreto CM, Salazar R, Carapeto F, Traweek RS, Leung CH, Gite S, Mehta J, Ingram DR, Wani KM, Vu KT, Parra ER, Lu W, Zhou J, Witt RG, Cope B, Thirasastr P, Lin HY, Scally CP, Conley AP, Ratan R, Livingston JA, Zarzour AM, Ludwig J, Araujo D, Ravi V, Patel S, Benjamin R, Wargo J, Wistuba II, Somaiah N, Roland CL, Keung EZ, Solis L, Wang WL, Lazar AJ, Nassif EF. The immune landscape of undifferentiated pleomorphic sarcoma. Front Oncol 12:1008484, 2022. e-Pub 2022. PMID: 36313661.
- Gounder MM, Merriam P, Ratan R, Patel SR, Chugh R, Villalobos VM, Thornton M, Van Tine BA, Abdelhamid AH, Whalen J, Yang J, Rajarethinam A, Duh MS, Bobbili PJ, Huynh L, Totev TI, Lax AK, Agarwal S, Demetri GD. Real-world Outcomes of Patients with Locally Advanced or Metastatic Epithelioid SArcoma. Cancer 127(8):1311-1317, 2021. e-Pub 2020. PMID: 33296083.
- Parkes A, Wang WL, Patel S, Leung CH, Lin H, Conley AP, Somaiah N, Araujo DM, Zarzour M, Livingston JA, Ludwig J, Roland CL, Ravi V, Benjamin RS, Ratan R. Outcomes of systemic therapy in metastatic phyllodes tumor of the breast. Breast Cancer Res Treat 186(3):871-882, 2021. e-Pub 2021. PMID: 33575859.
- Boyce-Fappiano D, Guadagnolo BA, Ratan R, Wang WL, Wagner MJ, Patel S, Livingston JA, Lin PP, Diao K, Mitra D, Farooqi A, Lazar AJ, Roland CL, Bishop AJ. "Evaluating the Soft Tissue Sarcoma Paradigm for the Local Management of Extraskeletal Ewing Sarcoma.". Oncologist 26(3):250-260, 2021. e-Pub 2020. PMID: 33289298.
- Gounder M, Schöffski P, Jones RL, Agulnik M, Cote GM, Villalobos VM, Attia S, Chugh R, Chen TW, Jahan T, Loggers ET, Gupta A, Italiano A, Demetri GD, Ratan R, Davis LE, Mir O, Dileo P, Van Tine BA, Pressey JG, Lingaraj T, Rajarethinam A, Sierra L, Agarwal S, Stacchiotti S. Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study. Lancet Oncol 21(11):1423-1432, 2020. e-Pub 2020. PMID: 33035459.
- Tarek N, Said R, Andersen CR, Suki TS, Foglesong J, Herzog CE, Tannir NM, Patel S, Ratan R, Ludwig JA, Daw NC. Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: The MD Anderson Cancer Center Experience. Cancers (Basel) 12(10), 2020. e-Pub 2020. PMID: 33050651.
- Bishop AJ, Landry JP, Roland CL, Ratan R, Feig BW, Moon BS, Zarzour MA, Wang WL, Lazar AJ, Lewis VO, Torres KE, Guadagnolo BA. Certain risk factors for patients with desmoid tumors warrant reconsideration of local therapy strategies. Cancer 126(14):3265-3273, 2020. e-Pub 2020. PMID: 32343846.
- Parkes A, Urquiola E, Bhosale P, Lin H, Watson K, Wang WL, Feig B, Torres K, Roland CL, Conley AP, Zarzour M, Livingston JA, Ratan R, Ludwig J, Araujo DM, Ravi V, Benjamin RS, Patel S, Somaiah N. PET/CT Imaging as a Diagnostic Tool in Distinguishing Well-Differentiated versus Dedifferentiated Liposarcoma. Sarcoma 2020:8363986, 2020. e-Pub 2020. PMID: 32565716.
- Bishop AJ, Zarzour MA, Ratan R, Torres KE, Feig BW, Wang WL, Lazar AJ, Moon BS, Roland CL, Guadagnolo BA. Long-term outcomes for patients with desmoid fibromatosis treated with radiation therapy: a 10-year update and re-evaluation of the role of radiation therapy for younger patients. Int J Radiat Oncol Biol Phys 103(5):1167-1174, 2019. e-Pub 2018. PMID: 30552963.
- Frezza AM, Jones RL, Lo Vullo S, Asano N, Lucibello F, Ben-Ami E, Ratan R, Teterycz P, Boye K, Brahmi M, Palmerini E, Fedenko A, Vincenzi B, Brunello A, Desar IME, Benjamin RS, Blay JY, Broto JM, Casali PG, Gelderblom H, Grignani G, Gronchi A, Hall KS, Mir O, Rutkowski P, Wagner AJ, Anurova O, Collini P, Dei Tos AP, Flucke U, Hornick JL, Lobmaier I, Philippe T, Picci P, Ranchere D, Renne SL, Sbaraglia M, Thway K, Wagrodzki M, Wang WL, Yoshida A, Mariani L, Kawai A, Stacchiotti S. Anthracycline, Gemcitabine, and Pazopanib in Epithelioid Sarcoma: A Multi-institutional Case Series. JAMA Oncol 4(9):e180219, 2018. e-Pub 2018. PMID: 29800950.
- Wagner MJ, Gopalakrishnan V, Ravi V, Livingston JA, Conley AP, Araujo D, Somaiah N, Zarzour MA, Ratan R, Wang WL, Patel SR, Lazar A, Ludwig JA, Benjamin RS. Vincristine, Ifosfamide, and Doxorubicin for Initial Treatment of Ewing Sarcoma in Adults. Oncologist 22(10):1271-1277, 2017. e-Pub 2017. PMID: 28710342.
- Goldberg JD, Zheng J, Ratan R, Small TN, Lai KC, Boulad F, Castro-Malaspina H, Giralt SA, Jakubowski AA, Kernan NA, O'Reilly RJ, Papadopoulos EB, Young JW, van den Brink MR, Heller G, Perales MA. Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant. Leuk Lymphoma 58(8):1-13, 2017. e-Pub 2017. PMID: 28073320.
- Barba P, Ratan R, Cho C, Ceberio I, Hilden P, Devlin SM, Maloy MA, Barker JN, Castro-Malaspina H, Jakubowski AA, Koehne G, Papadopoulos EB, Ponce DM, Sauter C, Tamari R, van den Brink MRM, Young JW, O'Reilly RJ, Giralt SA, Perales MA. Hematopoietic Cell Transplantation Comorbidity Index Predicts Outcomes in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Receiving CD34(+) Selected Grafts for Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant 23(1):67-74, 2017. e-Pub 2016. PMID: 27789361.
- Lamhamedi-Cherradi SE, Menegaz BA, Ramamoorthy V, Vishwamitra D, Wang Y, Maywald RL, Buford AS, Fokt I, Skora S, Wang J, Naing A, Lazar AJ, Rohren EM, Daw NC, Subbiah V, Benjamin RS, Ratan R, Priebe W, Mikos AG, Amin HM, Ludwig JA. IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma. J Natl Cancer Inst 108(12), 2016. e-Pub 2016. PMID: 27576731.
- Ratan, R., Mason, A., Sinnot, B., Goldfarb, D., and Fleming, R.. Drosophila importin a1 performs paralog-specific functions essential for gametogenesis. Genetics(178):839-850, 2008.
Invited Articles
- Ratan R, Roland CL, Bishop AJ. Desmoid Fibromatosis: Management in an Era of Increasing Options. Curr Oncol Rep 23(4):41, 2021. e-Pub 2021. PMID: 33719012.
- Amin HM, Morani AC, Daw NC, Lamhamedi-Cherradi SE, Subbiah V, Menegaz BA, Vishwamitra D, Eskandari G, George B, Benjamin RS, Patel S, Song J, Lazar AJ, Wang WL, Kurzrock R, Pappo A, Anderson PM, Schwartz GK, Araujo D, Cuglievan B, Ratan R, McCall D, Mohiuddin S, Livingston JA, Molina ER, Naing A, Ludwig JA. IGF-1R/mTOR targeted therapy for Ewing sarcoma: A meta-analysis of five IGF-1R-related trials matched to proteomic and radiologic predictive biomarkers. Cancers (Basel) 12(7):1768, 2020. e-Pub 2020. PMID: 32630797.
- Bishop AJ, Ratan R, Roland CL. Evolutioni n the management of desmoid tumors: Challenging the role of upfront surgical resection. Bulletin of the American College of Surgeons 104(10), 2019.
- Ratan R, Patel SR. Trabectedin and Eribulin: Where Do They Fit in the Management of Soft Tissue Sarcoma?. Curr Treat Options Oncol 18(6):34, 2017. PMID: 28534249.
- Ratan R, Patel SR. Chemotherapy for Soft Tissue Sarcoma. Cancer 122(19):2952-60, 2016. e-Pub 2016. PMID: 27434055.
Abstracts
- Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Mayinuer Maitituoheti, Hannah Beird, Chia-Chin Wu, Sandhya Krishnan, Davis R. Ingram, David McCall, Branko Cuglievan, P Andrew Futreal, Mark Titus, Alexander Lazar, Wei-Lien Wang, Kunal Rai, A Robert MacLeod, Ravin Ratan, J. Andrew Livingston, Najat C. Daw, Andrea Hayes-Jordan, Joseph A. Ludwig. The Epigenetic Impact and Therapeutic Opportunity of AR-Directed Therapy for DSRCT. CTOS 2022 Annual Meeting, 2022.
- Mrinal M. Gounder, Ravin Ratan, Thierry Alcindor, Patrick Schöffski, Winette T.A van der Graaf, Breelyn A. Wilky, Richard F. Riedel, Allison Lim, L. Mary Smith, Stephanie Moody, Steven Attia, Sant P. Chawla, Gina D'Amato, Noah Federman, Priscilla Merriam, Brian A. Van Tine, Bruno Vincenzi, Shivaani Kummar, Bernd Kasper. A Phase 3, Randomized Double-Blind Trial of Nirogacestat versus placebo for Progressing Desmoid Tumors/Aggressive Fibromatosis. CTOS 2022 Annual Meeting, 2022.
- Jonathan Gill, Anthony P. Conley, Neeta Somaiah, Dejka M. Araujo, Ravin Ratan, Kristi Posey, Robert S. Benjamin, Shreyaskumar Patel, Najat C. Daw, Douglas J. Harrison, Richard Gorlick, Heather Lin, Wei-Lien Wang, Behrang Amini, Nancy Gordon, J. Andrew Livingston. A Phase 1/2 Trial of Gemcitabine, Docetaxel, and Hydroxychloroquine in Advanced / Metastatic Osteosarcoma: Results of Phase 1. CTOS 2022 Annual Meeting, 2022.
- J.A. Ludwig, N. Federman, P. Anderson, M.E. Macy, L.E. Davis, R.F. Riedel, J.A. Muscal7, N.C. Daw, R. Ratan, J. Toretsky, X. Ianopulos, F.J. Hsu, J.B. Breitmeyer, P. Meyers. Phase I study of TK216, a novel anti-ETS agent for Ewing sarcoma. ESMO 2020, 2020.
- Gounder MM, Stachiotti S, Schoffski P, Cote GM, Villalobos VM, Jahan MJ, Chen TW, Ratan R, Gupta AA, Dileo P, Agulnik M, Italiano A, Attia S, Mir O, Pressey JG, Sierra L, Lingaraj T, Yang J, Agarwal S, Jones RL. Efficacy, safety, and immune priming effect of tazemetostat in patients with epithelioid sarcoma. J Clin Oncol 38(suppl), 2020.
- Somaiah N, Conley AP, Lin HY, Amini B, Sabir S, Araujo DM, Benjamin RS, Livingston JA, Patel S, Ratan R, Ravi V, Zarzour MA, Wang WL, Tate T, Roland CL, Daw NC, Futreal A, Lazar AJ, Wistuba II, Hwu P. A phase II multi-arm study of durvalumab and tremilimumab for advanced or metastatic sarcomas. J Clin Oncol 38(suppl), 2020.
- Roland CL, Keung EZ, Lazar AJ, Torres KE, Wang WL, Guadagnolo A, Bishop AJ, Lin HY, Feig BW, Bird JE, Lewis VO, Tawbi HA, Ratan R, Patel S, Wargo JA, Somaiah N. Preliminary results of a phase II study of neoadjuvant checkpoint blockade for surgically resectable undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated liposarcoma (DDLPS). J Clin Oncol 38(suppl), 2020.
- Hinchcliff E, Rumpf J, Ratan R, Fleming ND, Jazaeri AA, Pitcher P, Soliman PT. Present-day management of uterine leiomyosarcoma: Evaluation and treatment sequencing and other prognostic factors. J Clin Oncol 38(suppl), 2020.
- Subramaniam A, Zheng J, Yalamanchili S, Conley AP, Ratan R, Somaiah N, Livingston JA, Zarzour MA, Araujo DM, Benjamin RS, Patel S, Ravi V. Modulation of YAP/TAZ by statins to improve survival in epithelioid hemangioendothelioma (EHE). J Clin Oncol 38, 2020.
- Gounder M, Schoffski P, Stachiotti S, Villalobos V, Chugh R, Agulnik M, Attia S, Chen TW, Gupta A, Jahan T, Jones R, Italiano A, Blay JY, Cote JM, Demetri G, Loggers E, Ratan R, Fouladi M, Macy M, Makin G, Clawson A, Daigle S, Mencio C, Sapir I, Bourdeat F.. EZH2 inhibitor tazemetostat (taz) interim data in in adults and pediatric patients with INI-1 negative soft-tissue sarcomas (STS) including epithelioid sarcoma (ES). 2018 Connective Tissue Oncology Society Meeting, 2018.
- Stacchiotti, S, Blay JY, Jones RL, Demetri G, Italiano A, Thomas D, Chen TW, Schoffski P, Gil T, Jahan T, Cote G, Ratan R, Attia S, Roche M, Daigle S, Sapir I, Clawson A, Gounder M. A phase II, multicenter study of the EZH2 inhbitor tazemetostat in adults (INI-1 negative tumors cohort)(NCT02601950). Annals of Oncology 29(suppl_8), 2018.
- Parkes AM, Patel S, Leung CH, Lin HY, Conley AP, Somaiah N, Araujo DM, Zarzour MA, Livinston JA, Ludwig J, Ravi V, Benjamin R, Ratan R. Systemic therapy regimen outcomes in metastatic phyllodes tumor of the breast. 2018 ASCO Annual Meeting suppl, 2018.
- Subbiah V, Sankala KK, Ratan R, Garcia ES, Valentina B, Gil T, Villalobos V, Chawla S, Lardelli P, Siguero M, Kahatt CM, Sotos-Matos A, Ferrari S. Efficacy and Safety of Lurbinectedin (PM1183) in Ewing Sarcoma: Final Results from a phase 2 study. J Clin Oncol 36(suppl), 2018.
- Ratan R, Livingston JA, Wang W, Zarzour MA, Patel SR. CIC rearranged sarcomas: The MD Anderson experience with a rare, recently recognized entity. 2017 Connective Tissue Oncology Society Meeting, 2017.
- Frezza AM, Asano N, Jones R, Ratan R, Teterycz P, Gelderblom H, Boye K, Brahmi M, Palmerini E, Hindi N, Brunello A, Desar I, Grignani G, Fedenko AA, Vicenzi B, Papai Z, Kawai A, Lo Vullo S, Casali PG, Stachiotti S. Anthracycline, gemcitabine, and pazopanib in epithelioid sarcoma: Results of a retrospective multi-insitutional case series. J Clin Oncol 35(suppl), 2017.
- Conley AP, Huh WW, Roszik J, Harrison DJ, Hayes-Jordan AA, Kehr KA, Ratan R, Somaiah N, Ravi V, Araujo DM, Zarzour MA, Ludwig JA, Wang WL, Benjamin RS, Patel S. Clinical characteristics of adult alveolar rhabdomyosarcoma (ARMS) patients (Pts) on front-line therapies: An MD Anderson Cancer Center (MDACC) series. J Clin Oncol 34(suppl), 2017.
- Nathenson MA, Conley AP, Ratan R, Zarzour MA, Somaiah N, Araujo DM, Patel S, Benjamin RS, Ravi V. Efficacy of front-line chemotherapy for recurrent/metastatic adenosarcoma of the uterus. J Clin Oncol 34(suppl), 2016. e-Pub 2016.
Book Chapters
- Ratan R, Patel SR. Medical Oncology. In: Sarcomas: Evidence-Based Diagnosis and Management. 1. Springer, 2020.
- Ratan R, Ater J, Reiber AG, Rodriguez MA. Long-term survivorship in Adult and Pediatric Cancer. In: In: MD Anderson Manual of Medical Oncology. 3, 2016.
- Ratan R, Benjamin RS. Sarcomas of the Skull Base. In: Comprehensive Management of Skull Base Tumors. 2nd. Thieme: New York.