Richard R. Bouchard, Ph.D.
Department of Imaging Physics
About Dr. Bouchard
Today’s health care climate calls for medical technology that provides a safe, inexpensive, patient-specific, and point-of care diagnostic and therapeutic solution. Ultrasound-mediated imaging technologies, such as photoacoustic (PA) or elasticity imaging, allow clinicians to probe a patient’s specific molecular composition, permit assessment of tissue viscoelasticity, or afford unprecedented contrast for real-time image-guided therapy. Ultrasound-mediated imaging solutions can be provided at a price point, convenience, and operating ease that permits bedside utilization or straightforward intraoperative integration. Consequently, Dr. Bouchard has focused his research program on clinical photoacoustic-ultrasonic (PAUS) and acoustic radiation force (ARF)-based elasticity imaging technologies. He has targeted prostatic and cardiac diseases because of their high incidence in the United States and the reasonable access one can achieve to these organs with transrectal or intracardiac imaging transducers. Specifically, Dr. Bouchard is investigating novel uses of PAUS and (ARF)-based imaging in the detection, assessment, and treatment of cancer and cardiac disease. Although his primary research focus is the development of clinical techniques, Dr. Bouchard has also invested considerable effort in preclinical (i.e., murine model) PAUS imaging of molecular (i.e., nanoscale) theranostic probes, some of which share translational relevance with the aforementioned clinical applications.
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Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Imaging Physics - Research, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Regular Member, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX
Research Interests
Clinical photoacoustic-ultrasonic (PAUS) and acoustic radiation force (ARF)-based elasticity imaging technologies
Preclinical (i.e., murine model) PAUS imaging of molecular (i.e., nanoscale) theranostic probes
Education & Training
Degree-Granting Education
| 2010 | Duke University, Pratt School of Engineering, Durham, NC, USA, PHD, Biomedical Engineering |
| 2004 | Duke University, Pratt School of Engineering, Durham, NC, USA, BSE, Biomedical Engineering, Electrical Engineering, and Cultural Anthropology |
Experience & Service
Academic Appointments
Instructor, Department of Imaging Physics - Research, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2013
Visiting Scholar, Department of Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 2011 - 2013
Postdoctoral Fellow, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2012
Whitaker International Fellow, Department of Department of Biomedical Engineering, Erasmus Medical Center, Rotterdam, 2006 - 2007
Research Assistant, Duke University, Durham, NC, 2004 - 2010
Honors & Awards
| 2011 | Odyssey Fellowship, The University of Texas M D Anderson Cancer Center |
| 2006 | Whitaker International Fellowship |
| 2004 | James B. Duke Graduate Fellowship, Duke University |
| 2004 | National Science Foundation Graduate Fellowship |
| 2004 | Pratt-Gardner Fellowship, Duke University |
| 2003 | Phi Beta Kappa Honor Society |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Poulose AC, Veeranarayanan S, Mohamed MS, Aburto RR, Mitcham T, Bouchard RR, Ajayan PM, Sakamoto Y, Maekawa T, Kumar DS. Multifunctional Cu2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453. Sci Rep 6:35961, 2016. e-Pub 2016. PMID: 27775048.
- Sheikh Mohamed M, Poulose AC, Veeranarayanan S, Romero Aburto R, Mitcham T, Suzuki Y, Sakamoto Y, Ajayan PM, Bouchard RR, Yoshida Y, Maekawa T, Sakthi Kumar D. Plasmonic Fluorescent CdSe/Cu2S Hybrid Nanocrystals for Multichannel Imaging and Cancer Directed Photo-Thermal Therapy. Nanoscale 8(15):7876-88, 2016. PMID: 26584976.
- Gray JP, Dana N, Dextraze KL, Maier F, Emelianov S, Bouchard RR. Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions. Ultrason Imaging 38(1):96-112, 2016. e-Pub 2015. PMID: 26149314.
- Guha S, Shaw GK, Mitcham TM, Bouchard RR, and Bradley D. Smith.. Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH.”. Chemical Communications, 52(1), 2016.
- Mitcham T, Dextraze K, Taghavi, H, Melancon M, Bouchard R. Photoacoustic imaging driven by an interstitial irradiation source. Photoacoustics 3(2), 2015.
- Poulose AC, Veeranarayanan S, Mohamed MS, Nagaoka Y, Romero Aburto R, Mitcham T, Ajayan PM, Bouchard RR, Sakamoto Y, Yoshida Y, Maekawa T, Kumar DS. Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents. Nanoscale 7(18):8378-88, 2015. PMID: 25797920.
- Zhou M, Singhana B, Liu Y, Huang Q, Mitcham T, Wallace M, Stafford RJ, Bouchard R, Melancon MP. Theranostic Magnetic Gold Nanoshells for Magnetic Resonance and Photoacoustic Imaging-Guided Photothermal Therapy and Tumor Vasculature Visualization. Journal of Biomedical Nanotechnology 11(8):1385-1400, 2014.
- Bouchard R, Sahin O, Emelianov S. Ultrasound-guided Photoacoustic Imaging: current state and future development. IEEE Trans Ultrason Ferroelectr Freq Control 61(3):450-466, 2014. PMID: 24569250.
- Dana N, Di Biase L, Natale A, Emelianov S, Bouchard R. In-vitro Photoacoustic Visualization of Myocardial Ablation Lesions. Heart Rhythm 11(1):150-7, 2014. e-Pub 2013. PMID: 24080065.
- Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Mitcham TM, Fukuda T, Cox PJ, Bouchard RR, Maekawa T, Kumar DS, Torti SV, Mani SA, Ajayan PM. Fluorinated graphene oxide; a new multimodal material for biological applications. Adv Mater 25(39):5632-7, 2013. e-Pub 2013. PMID: 24038195.
- Candelaria RP, Hwang L, Bouchard RR, Whitman GJ. Ultrasound and Breast Cancer: Diagnosis, Staging, and Biopsy. Semin Ultrasound CT MR 3(34):213-225, 2013. PMID: 23768888.
- Mitcham T, Homan K, Frey W, Chen YS, Emelianov S, Hazle J, Bouchard R. Modulation of Photoacoustic Signal Generation from Metallic Surfaces. J Biomed Opt 18(5):56008, 2013. PMID: 23652344.
- Hsu SJ, Byram BC, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. Acoustic radiation force impulse imaging of mechanical stiffness propagation in myocardial tissue. Ultrason Imaging 34(3):142-58, 2012. PMID: 22972912.
- Su JL, Bouchard RR, Karpiouk AB, Hazle JD, Emelianov SY. Photoacoustic imaging of prostate brachytherapy seeds. Biomed Opt Express 2(8):2243-54, 2011. e-Pub 2011. PMID: 21833361.
- Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace M, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Control Release 172(1):152-158. e-Pub 2013. PMID: 23920038.
Book Chapters
- Zhou M, Lui L, Yao J, Bouchard R, Wang LV, Li C. Photoacoustic Imaging of Vasculature. In: Applications of Nanoparticles in Biomedical Imaging. Springer: New York, 2016.
- Rosenzweig S, Bouchard R, Polascik T, Zhai L, Nightingale K. Prostate Elastography and Photoacoustic Imaging. In: Image-Guided Prostate Cancer Treatments. Springer: Heidelberg, 2014.
- Aglyamov S, Bouchard RR, Graf IM, Emelianov SY. Breast Elasticity Imaging. In: Physics of Mammographic Imaging. Taylor & Franics: Boca Ranton, 2012.
Grant & Contract Support
| Title: | Imaging-Based Quantitative Analysis of Vascular Perfusion and Tissue Oxygenation to Improve Therapy of Hepatocellular Carcinoma |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Biodegradable nanoclusters for molecular cancer imaging |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Cancer Center Support Grant-Small Animal Imaging Facility |
| Funding Source: | CCSG |
| Role: | Lead of SAIF PAUS Core |