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Richard R. Bouchard, Ph.D.

Department of Imaging Physics, Division of Diagnostic Imaging

About Dr. Richard R. Bouchard

Today’s healthcare climate calls for medical technology that provides a safe, inexpensive, patient-specific, and point-of care diagnostic solution. Ultrasound-mediated imaging technologies, such as photoacoustic (PA), contrast-enhanced ultrasound (CEUS), or elasticity imaging, allow clinicians to probe a patient’s specific molecular composition, permit assessment of tissue viscoelasticity, or afford unprecedented contrast for real-time image-guided therapy. Ultrasound-mediated imaging solutions can be provided at a price point, convenience, and operating ease that permits bedside utilization or straightforward intraoperative integration. Consequently, Dr. Bouchard has focused his research program on clinically translatable photoacoustic-ultrasonic (PAUS), CEUS, and acoustic radiation force (ARF)-based elasticity imaging technologies. Specifically, Dr. Bouchard is investigating novel uses of these platforms in the detection, assessment, and treatment-monitoring of cancer and cardiac disease. To this end, Dr. Bouchard has invested considerable effort in development of quantitative imaging approaches for both endogenous (e.g., hemoglobin) and exogenous (e.g., molecularly targeted nanoparticles or phase-changing nanodroplets) in both tissue-mimicking phantom and preclinical (e.g., murine) models.

Primary Appointment

Associate Professor, Department of Imaging Physics - Research, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Regular Member, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Imaging Physics - Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Regular Member, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX

Research Interests

Clinical photoacoustic-ultrasonic (PAUS) and acoustic radiation force (ARF)-based elasticity imaging technologies

Preclinical (i.e., murine model) PAUS imaging of molecular (i.e., nanoscale) theranostic probes

Education & Training

Degree-Granting Education

2010	Duke University, Pratt School of Engineering, Durham, North Carolina, US, Biomedical Engineering, Ph.D
2004	Duke University, Pratt School of Engineering, Durham, North Carolina, US, Biomedical Engineering, Electrical Engineering, and Cultural Anthropology, BSE

Postgraduate Training

2011-2012	Postdoctoral Fellow, The University of Texas at Austin, Austin, Texas
2006-2007	Whitaker International Fellow, Erasmus Medical Center, Rotterdam
2004-2010	Research Assistant (NSF Graduate Research Fellow), Duke University, Durham, North Carolina

Experience & Service

Faculty Academic Appointments

Assistant Professor, Department of Imaging Physics - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2019

Instructor, Department of Imaging Physics - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2013

Postdoctoral Fellow, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2012

Visiting Scholar, Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 2011 - 2013

NSF Application Mentor, Duke University, Durham, NC, 2007 - 2008

Whitaker International Fellow, Department of Biomedical Engineering, Erasmus Medical Center, Rotterdam, 2006 - 2007

Undergraduate Researcher, Hindu Mandal Hospital, Dar es Salaam, 2004

Research Assistant, Duke University, Durham, NC, 2004 - 2010

Pratt Undergraduate Fellow, Duke University, Durham, NC, 2002 - 2004

NSF-REU Undergraduate Fellow, University of Kansas Medical Center, Kansas City, KS, 2002

Administrative Appointments/Responsibilities

Co-Director, Department of Medical Physics Program, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, 2022 - Present

Other Professional Positions

Consultant, 3D Systems, Inc, 2022 - Present

Institutional Committee Activities

Committee Member, Senate Research Affairs Committee, 2022 - 2024

Chair, GSBS Curriculum Committee, 2022 - 2023

Faculty-at-Large Committee Member, GSBS Curriculum Committee, 2021 - 2022

Committee Member, Imaging Physics Research Computational Resource Committee, 2020 - Present

Judge, Sylvan Rodriguez Foundation Scholarship, 2019

Member, Laser Safety Committee, 2019 - Present

Judge, Alfred G. Knudson Jr. GSV Dissertation Award, 2019 - 2024

Member, Blanchard Award Committee, 2018 - 2022

Member, Department of Imaging Physics Big Survey Recommendation Committee, MD Anderson, 2018

Committee Member, Medical Physics Graduate Program Admissions Committee, 2017 - Present

Committee Member, DIEC/ DI Faculty Senate Committee, 2016 - Present

Co-Chair, Odyssey Program Admissions Committee, 2016 - 2018

Member, Division of Diagnostic Imaging Faculty Functional Committee, 2016 - Present

Senator, Faculty Senate, 2016 - Present

Committee Member, Odyssey Program Advisory Committee, The University of Texas MD Anderson Cancer Center, 2015 - 2018

Committee Member, Curriculum Review Committee, 2014 - 2015

Committee Member, MRI & US Physics Section Chief Search Committee, Department of Imaging Physics, MD AndersonCancer Center, 2013

Ultrasound Core Leader, Small Animal Imaging Facility, 2012 - Present

Judge, BME Undergraduate Poster Symposium, 2011

Honors & Awards

2011	Odyssey Fellowship, University of Texas MD Anderson Cancer Center
2006	International Fellowship, Whitaker Foundation
2004	Graduate Research Fellowship, National Science Foundation
2004	Pratt-Gardner Fellowship, Duke University
2004	Howard G. Clark Award, Department of Biomedical Engineering, Duke University
2004	James B. Duke Graduate Fellowship, Duke University
2004	Magna Cum Laude with Distinction, Duke University
2003	Honor Society Member, Phi Beta Kappa Society
2003	3rd Place Overall, AUVSI International Underwater Robotics Competition
2003	Honor Society Member, Tau Beta Pi Engineering Society

Professional Memberships

World Molecular Imaging Society

2021 - Present

American Institute of Ultrasound in Medicine

2019 - Present

Institute of Electrical and Electronics Engineers

2012 - Present

Society of Photo-Optical Instrumentation Engineers

2011 - Present

Selected Presentations & Talks

Local Presentations

2022. Translational Quantitative Ultrasound-Mediated Molecular Imaging. Invited. Computational Integrative Biomedical Research Center Seminar in Quantitative and Computational Biosciences.
2019. Ultrasound-mediated Imaging for Cancer Diagnostics and Therapy Monitoring. Invited. Cancer Theranostics and Molecular Imaging Symposium, US.
2017. Advances in biomedical photoacoustic imaging. Invited. Department of Physics Seminar Series, US.
2016. Clinical Opportunities for Photoacoustic-Ultrasonic Imaging. Invited. MDACC Interventional Imaging Research Seminar Series. Houston, TX, US.
2016. You should not pursue a STEM field. Invited. Lone Star Community College STEM Lecture Series, US.
2014. Ultrasound-mediated imaging: from bench to bedside. Invited. Department of Computational and Applied Mathematics Spring Seminar Series. Houston, TX, US.
2013. Ultrasound Shear Wave Elastography: a promising non-invasive means of quantifying diffuse liver disease. Invited. Liver Group Monthly Meeting at MD Anderson Cancer Center. Houston, TX, US.
2012. Breast Elasticity Imaging. Invited. Breast Cancer Research Program Spring Annual Retreat at MD Anderson Cancer Center. Houston, TX, US.
2003. Development and FEM Modeling of ARFI-based phantoms. Conference. Triangle Undergraduate Research Symposium, US.

Regional Presentations

2024. Optimizing Acoustic Droplet Vaporization Volume of High-Boiling Point Perfluorocarbon Nanodroplets for Ultrasound Molecular Imaging. Poster. Next-Generation Computational Bio-Imaging Conference. Houston, TX, US.
2024. Photoacoustic-based assessment of PAtrace biodistribution, stability and clearance with cryofluroesence tomography validation. Poster. Next-Generation Computational Bio-Imaging Conference. Houston, TX, US.
2024. Accurate Photoacoustic Visualization of RF Ablation Lesions in a Large-Animal Model. Invited. Next-Generation Computational Bio-Imaging Conference. Houston, TX, US.
2022. Clinically Translatable Ultrasound-Mediated Imaging. Invited. State of Texas Chapter of Health Physics Society Spring Meeting, TX, US.
2017. Advances in Ultrasound-Mediated Imaging. Invited. Cancer Imaging Program Seminar Lecture Series, US.
2017. Preclinical Imaging Modalities Using Sound and Light. Invited. Midwest Preclinical Imaging Consortium, US.
2015. Mapping Oxygen Saturation in the Tumor Microenvironment via Photoacoustic-Ultrasonic Imaging. Conference. CPRIT Innovations in Cancer Research Conference, US.
2014. Advances in Ultrasound-Mediated Imaging. Invited. American Association of Physicists in Medicine Southwest Chapter Spring Meeting, US.
2011. More Than Just Sound: Advancements in Ultrasound-mediated Imaging Approaches. Invited. Preclinical Micro-ultrasound & Photoacoustic Imaging Symposium at Texas Children's Hospital. Houston, TX, US.

National Presentations

2025. Automated quantification of small animal liver tumor volume in longitudinal MR imaging using deep learning. Poster. American Association for Cancer Research Annual Meeting. Chicago, IL, US.
2025. Rapid automatic segmentation of murine lung volumes from micro-CT images using deep learning to reduce analysis burden. Poster. American Association for Cancer Research Annual Meeting. Chicago, IL, US.
2025. Photoacoustic-Ultrasound Assessment of Myocardial Ablations in a Large-Animal Model. Invited. Preclinical Imaging Consortium Annual Meeting. Houston, TX, US.
2025. Photoacoustic-Ultrasonic Imaging: Translational Potential and Pitfalls,” IEEE International Symposium on Biomedical Imaging. Invited. IEEE International Symposium on Biomedical Imaging. Houston, TX, US.
2024. A 3D-printed Ultrasound Transducer Adaptor to Mitigate Cardiac Motion for Epicardial Imaging. Conference. The George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Symposium and 8thAnnual Cardiovascular Engineering Symposium, US.
2024. Discriminating between Viable and Injured Myocardium with Quantitative Photoacoustic Imaging. Conference. The George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Symposium and 8th Annual Cardiovascular Engineering Symposium, US.
2023. Rosuvastatin-eluting Gold-nanoparticle-loaded Perivascular Wrap For Enhanced Arteriovenous Fistula Maturation In A Murine Model. Conference. American Heart Association Basic Cardiovascular Sciences Meeting, US.
2023. Translational Opportunities for Photoacoustic and Ultrasound-Mediated Imaging. Invited. American Association of Physicists in Medicine 65th Annual Meeting and Exhibition.
2023. Effect of Lipid Composition on Activation Potential of Phase-Shift Ultrasound Contrast Agents,. Conference. American Association of Physicists in Medicine 65th Annual Meeting and Exhibition, US.
2022. Comprehensive Evaluation of Molecular Specificity of ICGJ-encapsulating Agents for Clinically Translatable Molecular Photoacoustic Imaging. Conference. BMES National Conference, US.
2021. Advances in Quantification of Photoacoustic Imaging in vivo. Invited. NCI Co-Clinical Imaging Research Resources Program Annual Meeting, US.
2020. Cancer Diagnostics and Therapy Monitoring with Ultrasound-mediated Imaging. Invited. SPIE Medical Imaging, US.
2019. Preclinical Development of Quantitative Photoacoustic Imaging for Improved Cancer Diagnostics. Invited. SPIE Medical Imaging, US.
2019. Advanced Ultrasonography. Invited. 7th Intraoperative Imaging Society Meeting, US.
2019. Molecular Photoacoustic-Ultrasonic Imaging for Cancer Diagnostics and Therapy Monitoring. Invited. American Institute of Ultrasound in Medicine Convention, US.
2019. Photoacoustic Standardisation Consortium (IPASC): overview. Invited. SPIE Photonics West, US.
2019. Nonlinear Ultrasound Imaging of Phase-Change Perfluorocarbon Nanodroplets Activated by High-Frequency Ultrasound in a Tissue-Mimicking Environment. Conference. American Association of Physicists in Medicine 61st Annual Meeting and Exhibition, US.
2019. Quantitative Photoacoustic Imaging for the Assessment of Targeted LipoJICG in a Preclinical Model. Conference. American Association of Physicists in Medicine 61th Annual Meeting and Exhibition, US.
2019. Quantitative Photoacoustic Imaging for Assessment of Targeted Lipo-JICG in a Preclincal Model. Invited. Optoacoustic Imaging Symposium.
2019. Advanced Ultrasonography. Invited. 7th Intraoperative Imaging Society Meeting.
2019. Molecular Photoacoustic-Ultrasonic Imaging for Cancer Diagnostics and Therapy Monitoring. Invited. American Institute of Ultrasound in Medicine Convention.
2018. Ultrasound Activatable Nanodroplets Targeted to EGFR for Molecular Imaging with High-Frequency Ultrasound. Conference. American Association of Physicists in Medicine 60th Annual Meeting and Exhibition, US.
2018. MiR-873 functions as a potential tumor suppressor in pancreatic cancer by targeting KRAS. Conference. ACCR Annual Meeting, US.
2018. Optimization of a Spectroscopic Photoacoustic Imaging Technique to Noninvasively Assess Oxygen Saturation in Murine Femoral Bone Marrow. Conference. American Association of Physicists in Medicine 60th Annual Meeting and Exhibition, US.
2018. Removing Noise Bias in Photoacoustic-Based SO2 Estimates: A Simple Empirical SNR-Adaptive Thresholding Approach. Conference. American Association of Physicists in Medicine 60th Annual Meeting and Exhibition, US.
2017. Real-time monitoring of tumor-specific indocyanine green hepatic photothermal ablation using photoacoustic imaging. Conference. Society of Interventional Radiology Annual Meeting, US.
2017. Quantitative Assessment of Ultrasound Backscatter in 3D Printed Phantoms. Conference. BMES National Conference, US.
2017. MSOT-based SO2 assessment of femoral bone marrow in a murine model of leukemia. Invited. iThera MSOT North American Symposium, US.
2016. Multi-wavelength photoacoustic imaging of liposome-encapsulated dyes. Invited. iThera MSOT North American Symposium, US.
2016. Clinical Opportunities for Photoacoustic-Ultrasonic Imaging. Invited. American Institute of Ultrasound in Medicine Annual Convention, US.
2016. Clinical Opportunities for Photoacoustic-Ultrasonic Imaging. Conference. American Institute of Ultrasound in Medicine Annual Convention, US.
2016. Ultrasound Imaging of Absorbable Inferior Vena Cava Filters for Proper Placement. Conference. American Association of Physicists in Medicine 58th Annual Meeting and Exhibition, US.
2015. Preclinical Applications of Photoacoustic and Mircobubble-Contrast Imaging. Invited. Preclinical Imaging Workshop at Columbia University Medical Center. New York, NY, US.
2015. Photoacoustic Ultrasound-Guided Real-Time Imaging of Thermochemical Ablation in Ex Vivo Porcine Liver. Conference. Society of Interventional Radiology Annual Scientific Meeting, US.
2015. Ratiometric cellular sensor based on J-aggregate trapping in liposomes. Conference. SPIE Photonics West, US.
2015. Use of multi-wavelength photoacoustic imaging to distinguish HIFU ablation lesions. Conference. SPIE Photonics West, US.
2014. Development and Characterization of a Temporally Stable Tissue-Mimicking Photoacoustic-Ultrasonic Phantom. Conference. American Association of Physicists in Medicine 56th Annual Meeting and Exhibition, US.
2014. Characterization of myocardial ablation lesions using multi-wavelength photoacoustic imaging. Conference. SPIE Photonics West, US.
2014. Ultrasound Elasticity. Invited. American Association of Physicists in Medicine 56th Annual Meeting and Exhibition. Austin, TX, US.
2014. Three-dimensional in vivo photoacoustic tracking of targeted nanoparticles in a pancreatic cancer model. Conference. American Association for Cancer Research, US.
2014. Development of a Thermally Stable Phantom for Photoacoustic and Magnetic Resonance Temperature Imaging. Conference. American Association of Physicists in Medicine 56th Annual Meeting and Exhibition, US.
2013. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with Doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. Conference. 38th Society of Interventional Radiology Annual Scientific Meeting, US.
2013. Fluorinated graphene oxide (F-GO) – a new multimodal material for biological applications. Conference. 16th Nanotechnology Conference and Expo, US.
2012. Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging. Conference. SPIE Photonics West, US.
2012. Photoacoustic imaging of RF ablations in cardiac tissue. Conference. SPIE Photonics West, US.
2009. Optical Tracking of Acoustic Radiation Force Impulse-Induced Dynamics in a Tissue-Mimicking Phantom. Conference. 157th Meeting of the Acoustical Society of America, US.

International Presentations

2025. In Vivo Photoacoustic Imaging Can Accurately Determine Transmural Tissue Characterization. Poster. Heart Rhythm Society Annual Meeting. San Diego, US.
2025. Antibody-targeted, liposomes encapsulated indocyanine green dye J-aggregates as contrast agents for molecular photoacoustic imaging. Conference. SPIE Photonics West. San Francisco, US.
2025. Targeted, polymersome-encapsulated indocyanine green J-aggregates for clinically translatable molecular imaging. Conference. SPIE Photonics West. San Francisco, US.
2025. Optimization of nanosized contrast agents for ultrasound imaging. Conference. SPIE Photonics West. San Francisco, US.
2025. Photoacoustic Imaging to Identify Chromophore Spectra Emission Changes in Cardiac Tissue. Conference. IEEE International Symposium on Biomedical Imaging. Houston, US.
2024. Discriminating between Viable and Injured Myocardium with Quantitative Photoacoustic Imaging. Conference. The George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Symposium and 8th Annual Cardiovascular Engineering Symposium.
2024. Photoacoustic-based PAtrace biodistribution assessment with independent cryofluorescence tomography validation. Conference. 48th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2024. An Adaptive Ultrasound Sequence for Activation and Monitoring of Phase-Changing Nanodroplets. Conference. 48th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2024. Photoacoustic-based assessment of PAtrace biodistribution, stability, and clearance with cryofluorescence tomography validation. Conference. World Molecular Imaging Congress.
2024. Photoacoustic-Ultrasonic Imaging: Translational Potential and Pitfalls. Invited. SPIE Translational Biophotonics + Additive Manufacturing for Photonics.
2024. A 3D-printed Ultrasound Transducer Adaptor to Mitigate Cardiac Motion for Epicardial Imaging. Conference. The George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Symposium and 8thAnnual Cardiovascular Engineering Symposium.
2024. In Vivo Photoacoustic Imaging Accurately Characterizes Radiofrequencty Ablation Lesions. Poster. Heart Rhythm Society Annual Meeting, US.
2024. Accurate Photoacoustic Visualization of RF Ablation Lesions in a Large Animal Model. Conference. Proceedings of the 2024 IEEE Ultrasonics Symposium.
2024. Monitoring of liposome-encapsulated ICG biodistribution and stability with multi-wavelength PA imaging and cryofluorescence tomography. Conference. Proceedings of the 2024 IEEE Ultrasonics Symposium.
2024. Optimized and Adaptive High Frame-Rate Ultrasound Imaging of Perfluorocarbon Nanodroplet Activation and Recondensation. Conference. Proceedings of the 2024 IEEE Ultrasonics Symposium.
2023. Distributed aberration correction in handheld ultrasound based on tomographic estimates of the speed of sound. Conference. SPIE Medical Imaging.
2023. Translational Opportunities and Challenges for Photoacoustic-Ultrasonic Imaging. Invited. World Molecular Imaging Congress.
2023. Photoacoustic-Based Quantitation of Targeted PAtrace in a Preclinical Model of Ovarian Cancer. Conference. Proceedings of the 2023 IEEE Ultrasonics Symposium.
2023. Comparison of Photoacoustic-Based PAtrace Biodistribution Assessment with Independent Validation. Conference. 47th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2023. Low Intensity Focused Ultrasound Induces Targeted Subcortical Online Blood Oxygen-Level Dependent Activation in Humans. Conference. Society of Biological Psychiatry Annual Meeting.
2023. Iterative Sound Speed Tomography for Distributed Aberration Correction. Conference. Proceedings of the 2023 IEEE Ultrasonics Symposium.
2022. Adaptive Intraprocedural MRI-Based Planning of tFUS for Neuromodulation in Human Subject. Conference. Proceedings of the 2022 IEEE Ultrasonics Symposium.
2022. Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents. Conference. Artimino Medical Ultrasound Technology Conference.
2022. Quantitative Photoacoustic Imaging with PAtrace to Assess Treatment Response in a Preclinical Model of Breast Cancer. Conference. 46th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2022. Intraprocedural Planning of tFUS-Based Neuromodulation in Humans. Conference. 46th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2022. Noninvasive Quantitation of EGFR-Targeted PAtrace with Photoacoustic Imaging to Assess Treatment Response in a Preclinical Model of Breast Cancer. Conference. Proceedings of the 2022 IEEE Ultrasonics Symposium.
2021. In Vivo Imaging and Activation of Perfluorohexane Nanodroplets with High-Frequency Ultrasound. Conference. Proceedings of the 2021 IEEE Ultrasonics Symposium.
2021. Effects of Blood Oxygen Content on Longitudinal Relaxation of Hyperpolarized 13C Agents at 7 Tesla. Conference. ISMRM & SMRT Annual Meeting.
2021. Development of Quantitative Molecular Photoacoustic Imaging. Invited. Seminars of the Graduate Program in Physics Applied to Medicine and Biology of the Physics Department of the Faculty of Philosophy, Sciences and Letters of Ribeirão Preto.
2020. Cancer Diagnostics and Therapy Monitoring with Ultrasound-mediated Imaging. Invited. SPIE Medical Imaging.
2020. Beamforming Design for High-Resolution Low-Intensity Focused Ultrasound Neuromodulation. Conference. Proceedings of the 2020 IEEE International Conference on Acoustics, Speech, and Signal Processing.
2020. Molecularly targeted Lipo-JICG for in vivo quantitative photoacoustic imaging. Conference. SPIE Medical Imaging.
2020. High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets. Conference. SPIE Medical Imaging.
2020. In vivo quantitative photoacoustic imaging with PAtrace in TNBC model. Conference. Proceedings of the 2020 IEEE Ultrasonics Symposium.
2020. Optimization of High-Frequency-Ultrasound Imaging and Activation of High Boiling Point Activatable Perfluorocarbon Nanodroplets in a Tissue-Mimicking Phantom. Conference. Proceedings of the 2020 IEEE Ultrasonics Symposium.
2019. Liposome-encapsulated ICG dye J-aggregates for molecular photoacoustic imaging of ovarian cancer. Conference. World Molecular Imaging Congress.
2019. Preclinical Development of Quantitative Photoacoustic Imaging for Improved Cancer Diagnostics. Invited. SPIE Medical Imaging.
2019. In vivo quantitative photoacoustic imaging of targeted Lipo-JICG. Conference. Proceedings of the 2019 IEEE Ultrasonics Symposium.
2018. High-frequency molecular ultrasound imaging using targeted phase-change nanodroplets. Conference. Proceedings of the 2018 IEEE Ultrasonics Symposium.
2018. Assessment of blood oxygen saturation using spectroscopic photoacoustic imaging as a biomarker for disease progression in a small-animal leukemia model. Conference. SPIE Medical Imaging.
2018. Imaging biomarker development based on microbubble perfusion and oxygen saturation in a rat model of liver cancer. Conference. SPIE Medical Imaging.
2017. Quantitative 3D assessment of flow in a printed hydrogel vascular phantom. Conference. 42nd International Symposium on Ultrasonic Imaging and Tissue Characterization.
2017. Interaction of Leukemia and Bone Marrow Microenvironment in Mouse ALL Model is Associated with Disorganized Vasculature and Progressive Hypoxia. Conference. Proceedings of the Society of Hematologic Oncology Annual Meeting.
2017. Photoacoustic-based SO2 assessment of femoral bone marrow in a murine model of leukemia. Conference. World Molecular Imaging Congress.
2017. Photoacoustic-ultrasonic imaging biomarkers for treatment-response assessment of sorafenib in a rat model of hepatocellular carcinoma. Conference. Proceedings of the 2017 IEEE Ultrasonics Symposium.
2017. SO2 quantification of rat HCC tumors using fluence-corrected photoacoustic imaging. Conference. Proceedings of the 2017 IEEE Ultrasonics Symposium.
2017. Ultra-small Plasmonic NanoSensors for Cancer Theranostics. Conference. Cancer Nanotechnology Gordon Research Conference.
2017. Biodegradable nanoclusters for molecular cancer imaging and therapy. Conference. Cancer Nanotechnology Gordon Research Conference.
2016. Photoacoustic SO2 estimation with fluence correction in an interstitially irradiated excised prostate. Conference. Proceedings of the 2016 IEEE Ultrasonics Symposium.
2016. Assessment of photoacoustic-based sO2 estimation in an excised prostate. Conference. 41st International Symposium on Ultrasonic Imaging and Tissue Characterization.
2015. Cardiac Ablation Monitoring by Photoacoustic Imaging. Invited. Optics in Cardiology, NL.
2015. Environmentally-sensitive contrast agents for photoacoustic imaging of cancer cells. Conference. 40th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2015. Ratiometric Photoacoustic Imaging of Acidic pH. Conference. Proceedings of the 2015 IEEE Ultrasonics Symposium.
2015. Photoacoustic assessment of spatially and temporally varying oxygen saturation and perfusion in an orthotopic rat model of human hepatocellular carcinoma. Conference. Proceedings of the 2015 IEEE Ultrasonics Symposium.
2015. Magnetic resonance and photoacoustic imaging for treatment planning of brain tumor mediated by mesenchymal stem cell-labeled with multifunctional nanoparticle. Conference. 4th International Conference on Multifunctional, Hybrid and Nanomaterials.
2015. Clinical Opportunities for Photoacoustic-Ultrasonic Imaging. Invited. Medical Physics Lecture Series at the German Cancer Research Center, DE.
2015. Ultrasonic-based tissue oxygen saturation and perfusion assessment in a rat orthotopic liver tumor model. Conference. 40th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2014. Increasing the penetration depth of clinical photoacoustic imaging with interstitial irradiation. Conference. 39th International Symposium on Ultrasonic Imaging and Tissue Characterization, US.
2014. Coregistered photoacoustic perfusion assessment and targeted nanoparticle tracking in a prostate cancer model. Conference. 39th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2014. Assessment of HIFU-induced tissue damage using multi-wavelength photoacoustic imaging. Conference. Proceedings of the 2014 IEEE Ultrasonics Symposium.
2014. Expanding the clinical role of photoacoustic imaging: thermography and spectroscopy for guiding thermal ablation. Conference. 39th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2013. Transrectal photoacoustic-ultrasonic imaging enhancement through interstitial irradiation and targeted nanoparticles. Conference. Proceedings of the 2013 IEEE Ultrasonics Symposium.
2013. Transrectal photoacoustic-ultrasonic imaging for cancer diagnosis and therapy guidance in the prostate. Conference. 38th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2013. 3-D Assessment of Myocardial Ablation Lesions using Ultrasound-guided Multi-wavelength Photoacoustic Imaging. Conference. 34th Heart Rhythm Society Annual Scientific Meeting.
2013. Nanoparticle-mediated photothermal tumor therapy monitored with photoacoustic and magnetic resonance thermometry. Conference. Proceedings of the 2013 IEEE Ultrasonics Symposium.
2012. Modification of metallic surfaces for photoacoustic signal enhancement. Conference. Proceedings of the 2012 IEEE Ultrasonics Symposium.
2011. Rapid acquisition of ARFI-induced shear-wave velocity estimates using temporally-interleaved displacement tracking. Conference. 36th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2011. Quantitative Assessment of Photoacoustic and Ultrasonic Imaging of Prostate Brachytherapy Seeds. Conference. Proceedings of the 2011 IEEE Ultrasonics Symposium.
2010. Parametric pressure-volume analysis and acoustic radiation force impulse imaging of left ventricular function. Conference. Proceedings of the 2010 IEEE Ultrasonics Symposium.
2010. ARF-Driven Assessment of In Vivo Myocardial Cyclic Stiffness Variation. Conference. 9th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity.
2010. Acoustic radiation force-driven assessment of myocardial elasticity. Conference. 35rd International Symposium on Ultrasonic Imaging and Tissue Characterization.
2010. In vivo and in vitro investigation of shear wave velocity anisotropy in myocardial tissue. Conference. 35rd International Symposium on Ultrasonic Imaging and Tissue Characterization.
2010. Elasticity measurements through the cardiac cycle using acoustic radiation force impulse imaging (ARFI) on an intracardiac echocardiography (ICE) transducer. Conference. 35rd International Symposium on Ultrasonic Imaging and Tissue Characterization.
2010. Intracardiac Measurements of Elasticity using Acoustic Radiation Force Impulse (ARFI) Imaging: Temporal and Spatial Stability. Conference. Proceedings of the 2010 IEEE Ultrasonics Symposium: 682-685.
2009. Optical Quantification of Acoustic Radiation Force Impulse-Induced Dynamics in a Translucent Phantom. Conference. Proceedings of the 2009 IEEE Ultrasonics Symposium: 1942-1945.
2009. On the Characterization of Left Ventricular Function with Acoustic Radiation Force Impulse Imaging. Conference. Proceedings of the 2009 IEEE Ultrasonics Symposium: 1942-1945.
2009. Acoustic Radiation Force Impulse Imaging of Cardiovascular Imaging. Conference. Proceedings of the 2009 IEEE Ultrasonics Symposium: 163-168, US.
2009. Quantifying Acoustic Radiation Force Impulse-Induced Dynamics through Optical Methods: Experimental and Simulation Results. Conference. 8th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, US.
2009. Temporal and Spatial Stability of Acoustic Radiation Force-Driven Shear Wave Velocimetry in Myocardial Tissue In Vivo. Conference. 8th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, US.
2009. Acoustic Radiation Force-Induced Shear Wave Propagation in Cardiac Tissue. Conference. Proceedings of SPIE: 726512-1-8, US.
2008. In Vivo Investigation of Radiation Force-Induced Shear Wave Propagation in Myocardial Tissue. Conference. 7th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity.
2008. Acoustic Radiation Force Impulse Imaging of Myocardial Performance, Initial In Vivo Results. Conference. 7th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity.
2008. Combined Optical and Ultrasound-Based Tracking of an Acoustic Radiation Force-Induced Excitation. Conference. BMES Annual Fall Meeting, US.
2008. Advanced Pulse Sequences for ARFI Imaging. Conference. 33rd International Symposium on Ultrasonic Imaging and Tissue Characterization.
2008. A Combined ARFI Sequence for 2D Displacement Imaging and Shear Wave Velocity Mapping. Conference. Proceedings of the 2008 IEEE Ultrasonics Symposium: 2013-2016, US.
2008. Acoustic radiation force impulse imaging: optimization for clinical applications. Conference. 33rd International Symposium on Ultrasonic Imaging and Tissue Characterization.
2007. Combined Optical and Ultrasound-Based Tracking of an Acoustic Radiation Force-Induced Excitation. Conference. Proceedings of the 2007 IEEE Ultrasonics Symposium: 444-447.
2007. Robust intravascular optical coherence elastography driven by acoustic radiation pressure. Conference. Proceedings of SPIE: 66270E-1-10.
2006. Preliminary Investigations into Realtime Cardiac Acoustic Radiation Force Impulse Imaging. Conference. 31st International Symposium on Ultrasonic Imaging and Tissue Characterization.
2006. Parallel Tracking and Other Methods for Real-Time ARFI Imaging Systems. Conference. Proceedings of the 2006 IEEE Ultrasonics Symposium: 1005-1008.
2006. In vivo Acoustic Radiation Force Impulse Imaging of the Cardiac Cycle. Conference. Proceedings of the 2006 IEEE Ultrasonics Symposium: 756-759.
2006. Image quality, tissue heating and frame-rate trade-offs in ARFI imaging. Conference. 31st International Symposium on Ultrasonic Imaging and Tissue Characterization.
2006. A finite element model of an integrated indenter/acoustic radiation force impulse (ARFI) imaging system. Conference. 31st International Symposium on Ultrasonic Imaging and Tissue Characterization.
2005. A combined indenter/ARFI imaging system. Conference. IEEE Ultrasonics Symposium.
2005. Issues in real-time acoustic radiation force impulse imaging. Conference. 4th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity.
2003. Acoustic radiation force impulse imaging: a parametric analysis of factors affecting image quality. Conference. Proceedings of the 2003 IEEE Ultrasonic Symposium.
2003. Optimization of imaging parameters for acoustic radiation force impulse imaging. Conference. 28th International Symposium on Ultrasonic Imaging and Tissue Characterization.
2003. Measuring and modeling relaxation in viscoelastic phantoms with ARFI imaging. Conference. 28th International Symposium on Ultrasonic Imaging and Tissue Characterization.

Formal Peers

2013. Biomedical Photoacoustics: From Bench to Bedside. Invited. Prague, CZ.
2012. Photoacoustic Imaging and Sensing. Invited. Dresden, DE.

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Grant & Contract Support

Date:	2024 - 2026
Title:	Microbial Gas Vesicle Reporters to Induce Bacterial Buoyancy and Generate SONAR Signals
Funding Source:	Defense Advanced Research Projects Agency (DARPA)
Role:	PI
ID:	HR00112420377

Date:	2024 - 2027
Title:	Development of Radiopaque and Drug-Eluting Absorbable Vascular Grafts
Funding Source:	American Heart Association
Role:	Consult

Date:	2024 - 2027
Title:	Treatment Planning of ADC Therapy for Ovarian Cancer with Molecular Photoacoustic-Ultrasonic Imaging
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI
ID:	RP240311

Date:	2023 - 2025
Title:	Quantification and Distribution of a Novel Nanoparticle Designed to Target the Cardiac Conduction
Funding Source:	Gulf Coast Consortia
Role:	PI
ID:	AWD00007826

Date:	2022 - 2026
Title:	Biodegradable Radiopaque Polymeric Scaffolds Loaded with Mesenchymal Stem Cells for Image-Guided Arteriovenous Fistula Maturation and Long-Term Patency
Funding Source:	NIH/NHLBI
Role:	Co-I
ID:	5R01HL159960-03

Date:	2022 - 2027
Title:	Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology
Funding Source:	NIH/NCI
Role:	Mentor
ID:	5T32CA196561-08

Date:	2019 - 2026
Title:	Cancer Center Support Grant - Small Animal Imaging Facility
Funding Source:	NIH/NCI
Role:	Ultrasound/Photoacoustic Service Leader
ID:	4P30CA016672-48

Selected Publications

Peer-Reviewed Articles

Fan B, Goodman W, Sheth SA, Bouchard RR, Aazhang B. Computational sensitivity evaluation of ultrasound neuromodulation resolution to brain tissue sound speed with robust beamforming. Sci Rep 15(1):11251, 2025. e-Pub 2025. PMID: 40175469.
Chou T, Kochanowski BJ, Hayden A, Borron BM, Barbeiro MC, Xu J, Kim JW, Zhang X, Bouchard RR, Phan KL, Goodman WK, Dougherty DD. A Low-Intensity Transcranial Focused Ultrasound Parameter Exploration Study of the Ventral Capsule/Ventral Striatum. Neuromodulation 28(1):146-154, 2025. e-Pub 2025. PMID: 38691076.
Barcena AJR, Perez JVD, Bernardino MR, Damasco JA, San Valentin EMD, Klusman C, Martin B, Canlas GM, Heralde FM 3rd, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Bismuth-infused perivascular wrap facilitates delivery of mesenchymal stem cells and attenuation of neointimal hyperplasia in rat arteriovenous fistulas. Biomater Adv 166:214052, 2025. e-Pub 2025. PMID: 39341164.
Mathuria N, Vishwanath K, Brero G, Fallon BC, Martino A, Willson RC, Filgueira CS, Bouchard RR. Open-chest cardiac ultrasound-mediated imaging with a vacuum coupler. Med Phys, 2024. e-Pub 2024. PMID: 39545706.
Mathuria N, Vishwanath K, Fallon BC, Martino A, Brero G, Willson RC, Valderrabano M, Filgueira CS, Bouchard RR. In vivo assessment of cardiac radiofrequency ablation in a large-animal model using photoacoustic-ultrasound imaging. medRxiv, 2024. e-Pub 2024. PMID: 39371164.
Shen Q, Li Z, Wang Y, Meyer MD, De Guzman MT, Lim JC, Xiao H, Bouchard RR, Lu GJ. 50-nm Gas-Filled Protein Nanostructures to Enable the Access of Lymphatic Cells by Ultrasound Technologies. Adv Mater 36(28):e2307123, 2024. e-Pub 2024. PMID: 38533973.
Barcena AJR, Perez JVD, Bernardino MR, San Valentin EMD, Damasco JA, Klusman C, Martin B, Court KA, Godin B, Canlas G, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Controlled Delivery of Rosuvastatin or Rapamycin through Electrospun Bismuth Nanoparticle-Infused Perivascular Wraps Promotes Arteriovenous Fistula Maturation. ACS Appl Mater Interfaces 16(26):33159-33168, 2024. e-Pub 2024. PMID: 38912610.
Kawelah MR, Han S, Atila Dincer C, Jeon J, Brisola J, Hussain AF, Jeevarathinam AS, Bouchard R, Marras AE, Truskett TM, Sokolov KV, Johnston KP. Antibody-Conjugated Polymersomes with Encapsulated Indocyanine Green J-Aggregates and High Near-Infrared Absorption for Molecular Photoacoustic Cancer Imaging. ACS Appl Mater Interfaces 16(5):5598-5612, 2024. e-Pub 2024. PMID: 38270979.
Klusman, C, Martin, B, Perez, JD, Barcena, AR, Bernardino, MR, Valentin, ED, Damasco, J, Del Mundo, HC, Court, KA, Godin, B, Canlas, GM, Fowlkes, NW, Bouchard, RR, Cheng, J, Huang, SY, Melancon, MP. Rosuvastatin-Eluting Gold-Nanoparticle-Loaded Perivascular Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model. Advanced Fiber Materials 5(6):1986-2001, 2023. e-Pub 2023.
Barcena AJR, Perez JVD, Bernardino MR, Damasco JA, Cortes A, Del Mundo HC, San Valentin EMD, Klusman C, Canlas GM, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Bioresorbable Mesenchymal Stem Cell-Loaded Electrospun Polymeric Scaffold Inhibits Neointimal Hyperplasia Following Arteriovenous Fistula Formation in A Rat Model of Chronic Kidney Disease. Adv Healthc Mater 12(26):e2300960, 2023. e-Pub 2023. PMID: 37395729.
Fan B, Goodman W, Cho RY, Sheth SA, Bouchard RR, Aazhang B. Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation. Sci Rep 13(1):13403, 2023. e-Pub 2023. PMID: 37591991.
Barcena AJR, Perez JVD, Damasco JA, Bernardino MR, San Valentin EMD, Klusman C, Martin B, Cortes A, Canlas GM, Del Mundo HC, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Gold Nanoparticles for Monitoring of Mesenchymal Stem-Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistula Maturation. Int J Mol Sci 24(14), 2023. e-Pub 2023. PMID: 37511512.
Ali R, Mitcham TM, Singh M, Doyley MM, Bouchard RR, Dahl JJ, Duric N. Sound Speed Estimation for Distributed Aberration Correction in Laterally Varying Media. IEEE Trans Comput Imaging 9:367-382, 2023. e-Pub 2023. PMID: 37997603.
Mitcham TM, Nevozhay D, Chen Y, Nguyen LD, Pinton GF, Lai SY, Sokolov KV, Bouchard RR. Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents. Med Phys 49(4):2212-2219, 2022. e-Pub 2022. PMID: 35195908.
Wood CA, Han S, Kim CS, Wen Y, Sampaio DRT, Harris JT, Homan KA, Swain JL, Emelianov SY, Sood AK, Cook JR, Sokolov KV, Bouchard RR. Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates. Nat Commun 12(1):5410, 2021. e-Pub 2021. PMID: 34518530.
Paulsen SJ, Mitcham TM, Pan CS, Long J, Grigoryan B, Sazer DW, Harlan CJ, Janson KD, Pagel MD, Miller JS, Bouchard RR. Projection-based stereolithography for direct 3D printing of heterogeneous ultrasound phantoms. PLoS One 16(12):e0260737, 2021. e-Pub 2021. PMID: 34882719.
Muñoz NM, Dupuis C, Williams M, Dixon K, McWatters A, Avritscher R, Bouchard R, Kaseb A, Schachtschneider KM, Rao A, Sheth RA. Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma. Commun Biol 3(1):783, 2020. e-Pub 2020. PMID: 33335270.
Changalvaie B, Han S, Moaseri E, Scaletti F, Truong L, Caplan R, Cao A, Bouchard R, Truskett TM, Sokolov KV, Johnston KP. Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging. ACS Appl Mater Interfaces 11(50):46437-46450, 2019. e-Pub 2019. PMID: 31804795.
Han S, Bouchard R, Sokolov KV. Molecular Photoacoustic Imaging with Ultra-small Gold Nanoparticles. Biomed Opt Express 10(7):3472-3483, 2019. e-Pub 2019. PMID: 31360601.
Wood C, Harutyunyan K, Sampaio DRT, Konopleva M, Bouchard R. Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia. Photoacoustics 14:31-36, 2019. e-Pub 2019. PMID: 31049286.
Naser MA, Sampaio DRT, Munoz NM, Wood CA, Mitcham TM, Stefan W, Sokolov KV, Pavan TZ, Avritscher R, Bouchard RR. Improved photoacoustic-based oxygen saturation estimation with SNR-regularized local fluence correction. IEEE Trans Med Imaging 38(2):561-571, 2019. e-Pub 2019. PMID: 30207951.
Qiao Y, Gumin J, MacLellan CJ, Gao F, Bouchard R, Lang FF, Stafford RJ, Melancon MP. Magnetic resonance and photoacoustic imaging of brain tumor mediated by mesenchymal stem cell labeled with multifunctional nanoparticle introduced via carotid artery injection. Nanotechnology 29(16):165101, 2018. e-Pub 2018. PMID: 29438105.
Noh K, Mangala LS, Han HD, Zhang N, Pradeep S, Wu SY, Ma S, Mora E, Rupaimoole R, Jiang D, Wen Y, Shahzad MMK, Lyons Y, Cho M, Hu W, Nagaraja AS, Haemmerle M, Mak CSL, Chen X, Gharpure KM, Deng H, Xiong W, Kingsley CV, Liu J, Jennings N, Birrer MJ, Bouchard RR, Lopez-Berestein G, Coleman RL, An Z, Sood AK. Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis. Cell Rep 21(10):2785-2795, 2017. e-Pub 2017. PMID: 29212026.
Mitcham T, Taghavi H, Long J, Wood C, Fuentes D, Stefan W, Ward J, Bouchard R. Photoacoustic-based sO2 estimation through excised bovine prostate tissue with interstitial light delivery. Photoacoustics 7:47-56, 2017. e-Pub 2017. PMID: 28794990.
Sivakumar B, Aswathy RG, Romero-Aburto R, Mitcham T, Mitchel KA, Nagaoka Y, Bouchard RR, Ajayan PM, Maekawa T, Sakthikumar DN. Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents. Biomater Sci 5(3):432-443, 2017. e-Pub 2017. PMID: 28059418.
Chen CT, Chen YC, Du Y, Han Z, Ying H, Bouchard RR, Hsu JL, Hsu JM, Mitcham TM, Chen MK, Sun HL, Chang SS, Li D, Chang P, DePinho RA, Hung MC. A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. American Journal Cancer Research 7(3):657-672, 2017. e-Pub 2017. PMID: 28401019.
Poulose AC, Veeranarayanan S, Mohamed MS, Aburto RR, Mitcham T, Bouchard RR, Ajayan PM, Sakamoto Y, Maekawa T, Kumar DS. Multifunctional Cu2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453. Sci Rep 6:35961, 2016. e-Pub 2016. PMID: 27775048.
Sheikh Mohamed M, Poulose AC, Veeranarayanan S, Romero Aburto R, Mitcham T, Suzuki Y, Sakamoto Y, Ajayan PM, Bouchard RR, Yoshida Y, Maekawa T, Sakthi Kumar D. Plasmonic Fluorescent CdSe/Cu2S Hybrid Nanocrystals for Multichannel Imaging and Cancer Directed Photo-Thermal Therapy. Nanoscale 8(15):7876-88, 2016. e-Pub 2016. PMID: 26584976.
Guha S, Shaw GK, Mitcham TM, Bouchard RR, Smith BD. Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH. Chem Commun (Camb) 52(1):120-3, 2016. e-Pub 2016. PMID: 26502996.
Gray JP, Dana N, Dextraze KL, Maier F, Emelianov S, Bouchard RR. Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions. Ultrason Imaging 38(1):96-112, 2016. e-Pub 2016. PMID: 26149314.
Zhou M, Singhana B, Liu Y, Huang Q, Mitcham T, Wallace MJ, Stafford RJ, Bouchard RR, Melancon MP. Photoacoustic- and Magnetic Resonance-Guided Photothermal Therapy and Tumor Vasculature Visualization Using Theranostic Magnetic Gold Nanoshells. J Biomed Nanotechnol 11(8):1442-50, 2015. e-Pub 2015. PMID: 26295144.
Mitcham T, Dextraze K, Taghavi, H, Melancon M, Bouchard R. Photoacoustic imaging driven by an interstitial irradiation source. Photoacoustics 3(2), 2015. e-Pub 2015.
Poulose AC, Veeranarayanan S, Mohamed MS, Nagaoka Y, Romero Aburto R, Mitcham T, Ajayan PM, Bouchard RR, Sakamoto Y, Yoshida Y, Maekawa T, Kumar DS. Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents. Nanoscale 7(18):8378-88, 2015. e-Pub 2015. PMID: 25797920.
Zhou M, Singhana B, Liu Y, Huang Q, Mitcham T, Wallace M, Stafford RJ, Bouchard R, Melancon MP. Photoacoustic-and Magnetic Resonance-Guided Photothermal Therapy and Tumor Vasculature Visualization Using Theranostic MAgnetic Gold Nanoshells. Journal of Biomedical Nanotechnology 11(8):1442-1450, 2015. e-Pub 2015.
Bouchard R, Sahin O, Emelianov S. Ultrasound-guided Photoacoustic Imaging: current state and future development. IEEE Trans Ultrason Ferroelectr Freq Control 61(3):450-466, 2014. e-Pub 2014. PMID: 24569250.
Dana N, Di Biase L, Natale A, Emelianov S, Bouchard R. In-vitro Photoacoustic Visualization of Myocardial Ablation Lesions. Heart Rhythm 11(1):150-7, 2014. e-Pub 2014. PMID: 24080065.
Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Mitcham TM, Fukuda T, Cox PJ, Bouchard RR, Maekawa T, Kumar DS, Torti SV, Mani SA, Ajayan PM. Fluorinated graphene oxide; a new multimodal material for biological applications. Adv Mater 25(39):5632-7, 2013. e-Pub 2013. PMID: 24038195.
Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace M, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Control Release 172(1):152-158. e-Pub 2013. PMID: 23920038.
Candelaria RP, Hwang L, Bouchard RR, Whitman GJ. Ultrasound and Breast Cancer: Diagnosis, Staging, and Biopsy. Semin Ultrasound CT MR 3(34):213-225, 2013. e-Pub 2013. PMID: 23768888.
Mitcham T, Homan K, Frey W, Chen YS, Emelianov S, Hazle J, Bouchard R. Modulation of Photoacoustic Signal Generation from Metallic Surfaces. J Biomed Opt 18(5):56008, 2013. e-Pub 2013. PMID: 23652344.
Hsu SJ, Byram BC, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. Acoustic radiation force impulse imaging of mechanical stiffness propagation in myocardial tissue. Ultrason Imaging 34(3):142-58, 2012. e-Pub 2012. PMID: 22972912.
Cook JR, Bouchard RR, Emelianov SY. Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging. Biomed Opt Express 2(11):3193-206, 2011. e-Pub 2011. PMID: 22076278.
Su JL, Bouchard RR, Karpiouk AB, Hazle JD, Emelianov SY. Photoacoustic imaging of prostate brachytherapy seeds. Biomed Opt Express 2(8):2243-54, 2011. e-Pub 2011. PMID: 21833361.
Bouchard RR, Hsu SJ, Palmeri ML, Rouze NC, Nightingale KR, Trahey GE. Acoustic radiation force-driven assessment of myocardial elasticity using the displacement ratio rate (DRR) method. Ultrasound Med Biol 37(7):1087-100, 2011. e-Pub 2011. PMID: 21645966.
Bouchard RR, Streeter JE, Palmeri ML, Pinton GF, Trahey GE, Dayton PA. Optical tracking of acoustic radiation force impulse-induced dynamics in a tissue-mimicking phantom. J Acoust Soc Am 126(5):2733-45, 2009. e-Pub 2009. PMID: 19894849.
Bouchard RR, Hsu SJ, Wolf PD, Trahey GE. In vivo cardiac, acoustic-radiation-force-driven, shear wave velocimetry. Ultrason Imaging 31(3):201-13, 2009. e-Pub 2009. PMID: 19771962.
Hsu SJ, Bouchard RR, Dumont DM, Ong CW, Wolf PD, Trahey GE. Novel acoustic radiation force impulse imaging methods for visualization of rapidly moving tissue. Ultrason Imaging 31(3):183-200, 2009. e-Pub 2009. PMID: 19771961.
Bouchard RR, Dahl JJ, Hsu SJ, Palmeri ML, Trahey GE. Image quality, tissue heating, and frame rate trade-offs in acoustic radiation force impulse imaging. IEEE Trans Ultrason Ferroelectr Freq Control 56(1):63-76, 2009. e-Pub 2009. PMID: 19213633.
Bouchard RR, Van Soest G, Trahey GE, Van Der Steen AF. Optical tracking of superficial dynamics from an acoustic radiation force-induced excitation. Ultrason Imaging 31(1):17-30, 2009. e-Pub 2009. PMID: 19507680.
Zhai L, Palmeri ML, Bouchard RR, Nightingale RW, Nightingale KR. An integrated indenter-ARFI imaging system for tissue stiffness quantification. Ultrason Imaging 30(2):95-111, 2008. e-Pub 2008. PMID: 18939611.
Hsu SJ, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. In vivo assessment of myocardial stiffness with acoustic radiation force impulse imaging. Ultrasound Med Biol 33(11):1706-19, 2007. e-Pub 2007. PMID: 17698282.
Palmeri ML, Sharma AC, Bouchard RR, Nightingale RW, Nightingale KR. A finite-element method model of soft tissue response to impulsive acoustic radiation force. IEEE Trans Ultrason Ferroelectr Freq Control 52(10):1699-712, 2005. e-Pub 2005. PMID: 16382621.

Review Articles

Mathuria N, Vishwanath K, Fallon BC, Martino A, Brero G, Willson RC, Valderrabano M, Filgueira CS, Bouchard RR. In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging. JACC Clin Electrophysiol 11(5):1024-1029, 2025. e-Pub 2025. PMID: 40310313.

Abstracts

Mathuria N, Fallon BC, Vishwanath K, Martino A, Brero G, Willson RC, Valderrabano M, Filgueira CS, Bouchard RR. In Vivo Photoacoustic Imaging Can Accurately Determine Transmural Tissue Characterization. Heart Rhythm Society Annual Meeting 22(4):S627, 2025. e-Pub 2025.
Aji AM, Thomas M Kierski TM, Rojas JD, Gessner RC, Reisner Y, Milman-Krentsis I, Hazle J, Maldonado KL, Kingsley C, Bouchard RR, Czernuszewicz TJ. Automated quantification of small animal liver tumor volume in longitudinal MR imaging using deep learning. Rapid automatic segmentation of murine lung volumes from micro-CT images using deep learning to reduce analysis burden 85(8):7444, 2025. e-Pub 2025.
Aji AM, Thomas M Kierski TM, Rojas JD, Gessner RC, Reisner Y, Milman-Krentsis I, Hazle J, Maldonado KL, Kingsley C, Bouchard RR, Czernuszewicz TJ. Rapid automatic segmentation of murine lung volumes from micro-CT images using deep learning to reduce analysis burden. American Association for Cancer Research Annual Meeting 85(8):6315, 2025. e-Pub 2025.
Jeevarathinam A, Kawelah MR, Jones CE, Hussain AF, Wood CA, Marras AE, Truskett TM, Bouchard RR, Johnston KP, Sokolov KV. Targeted, polymersome-encapsulated indocyanine green J-aggregates for clinically translatable molecular imaging. SPIE Photonics West PC1339:PC133190F, 2025. e-Pub 2025.
Nevozhay D, Dyall CR, Mitcham TM, Chen Y, Nguyen LD, Pinton GF, Lai SY, Bouchard RR, Sokolov KV. Optimization of nanosized contrast agents for ultrasound imaging. SPIE Photonics West PC13339:PC1333907, 2025. e-Pub 2025.
Jeevarathinam AS, Jones CE, Zandbergen C, Wen Y, Sood A, Sokolov K, Bouchard R. Antibody-targeted, liposomes encapsulated indocyanine green dye J-aggregates as contrast agents for molecular photoacoustic imaging. SPIE Photonics West PC13339:PC1333906, 2025. e-Pub 2025.
Wood C, Jones C, Soundaram A, Han S, Watson R, Meyer J, Cook J, Roy A, Burdick JA, Sokolov K, Bouchard R. Photoacoustic-based PAtrace Biodistribution Assessment with Independent Cryofluorescence Tomography Validation. 48th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2024. e-Pub 2024.
Wood C, Jones C, Soundaram A, Han S, Watson R, Meyer J, Cook J, Roy A, Burdick JA, Sokolov K, Bouchard R. Photoacoustic-based assessment of PAtrace biodistribution, stability, and clearance with cryofluorescence tomography validation. World Molecular Imaging Congress, 2024. e-Pub 2024.
Dyall CR, Nevozhay D, Mitcham TM, Chen Y, Lai S, Sokolov K, Bouchard RR. An Adaptive Ultrasound Sequence for Activation and Monitoring of Phase-Changing Nanodroplets. 48th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2024. e-Pub 2024.
Mathuria N, Vishwanathg K, Brero G, Fallon B, Martino A, Willson R, Valderrabano M, Filgueira C, Bouchard R. In Vivo Photoacoustic Imaging Accurately Characterizes Radiofrequency Ablation Lesions. Heart Rhythm Society Annual Meeting 21(5):S585, 2024. e-Pub 2024.
Ali R, Mitcham T, Singh M, Bouchard R, Doyley M, Dahl J, Duric N. Iterative Sound Speed Tomography for Distributed Aberration Correction. Proceedings of the 2023 IEEE Ultrasonics Symposium:1-4, 2023. e-Pub 2023.
Martin B, Klusman C, Perez JVD, Barcena AJR, Bernardino MR, EMDS V, Damasco JA, Mundoa HCD, Court KA, Godin B, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Rosuvastatin-eluting Gold-nanoparticle-loaded Perivascular Wrap For Enhanced Arteriovenous Fistula Maturation In A Murine Model. American Heart Association Basic Cardiovascular Sciences Meeting 133, 2023. e-Pub 2023.
Kim J, Zhang X, Bouchard RR, Avendano-Ortega M, Chou T, Dougherty DD, Xu J, Goodman WK. Low Intensity Focused Ultrasound Induces Targeted Subcortical Online Blood Oxygen-Level Dependent Activation in Humans. Society of Biological Psychiatry Annual Meeting 93(9):S264-S265, 2023. e-Pub 2023.
Ali R, Mitcham T, Singh M, Bouchard R, Dahl J, Doyley M, Duric N. Distributed aberration correction in handheld ultrasound based on tomographic estimates of the speed of sound. SPIE Medical Imaging 12470:25-35, 2023. e-Pub 2023.
Nevozhay D, Mitcham TM, Chen Y, Lai SY, Bouchard R, Sokolov KV, Wood CA. Effect of Lipid Composition on Activation Potential of Phase-Shift Ultrasound Contrast Agents. American Association of Physicists in Medicine 65th Annual Meeting and Exhibition, 2023. e-Pub 2023.
Wood C, Han S, Watson R, Nevozhay D, Vu TC, Bayraktar E, Wen Y, Meyer J, Cook J, Roy A, Burdick JA, Sood A, Sokolov K, Bouchard R. Comparison of Photoacoustic-Based PAtrace Biodistribution Assessment with Independent Validation. 47th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2023. e-Pub 2023.
Wood C, Han S, Watson R, Nevozhay D, Vu TC, Bayraktar E, Wen Y, Meyer J, Cook J, Roy A, Burdick JA, Sood A, Sokolov K, Bouchard R. Photoacoustic-Based Quantitation of Targeted PAtrace in a Preclinical Model of Ovarian Cancer. Proceedings of the 2023 IEEE Ultrasonics Symposium, 2023. e-Pub 2023.
Bouchard RR. Translational Opportunities for Photoacoustic and Ultrasound-Mediated Imaging. American Association of Physicists in Medicine 65th Annual Meeting and Exhibition, 2023. e-Pub 2023.
Wood C, Han S, Nevozhay D, Meyer J, Rauch G, Cook J, Sokolov K, Bouchard R. Noninvasive Quantitation of EGFR-Targeted PAtrace with Photoacoustic Imaging to Assess Treatment Response in a Preclinical Model of Breast Cancer. Proceedings of the 2022 IEEE Ultrasonics Symposium, 2022. e-Pub 2022.
Han S, Zandbergen C, Kawelah M, Cook JR, Johnston K, Bouchard R, Sokolov KV. Comprehensive Evaluation of Molecular Specificity of ICGJ-encapsulating Agents for Clinically Translatable Molecular Photoacoustic Imaging. BMES National Conference, 2022. e-Pub 2022.
Wood C, Han S, Nevozhay D, Meyer J, Rauch G, Cook J, Sokolov K, Bouchard R. Quantitative Photoacoustic Imaging with PAtrace to Assess Treatment Response in a Preclinical Model of Breast Cancer. 46th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2022. e-Pub 2022.
Bouchard R, Zhang X, Xu J, Kim J, Ortega MA, Sheth S, Goodman W. Adaptive Intraprocedural MRI-Based Planning of tFUS for Neuromodulation in Human Subjects. Proceedings of the 2022 IEEE Ultrasonics Symposium, 2022. e-Pub 2022.
Bouchard R, Zhang X, Xu J, Kim J, Ortega MA, Sheth S, Goodman W. Intraprocedural Planning of tFUS-Based Neuromodulation in Humans. 46th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2022. e-Pub 2022.
Nevozhay D, Mitcham T, Chen Y, Nguyen L, Pinton G, Lai S, Sokolov K, Bouchard R. Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents. Artimino Medical Ultrasound Technology Conference, 2022. e-Pub 2022.
Michel K, Harlan C, Mitcham T, Merritt M, Bouchard R, Bankson J. Effects of Blood Oxygen Content on Longitudinal Relaxation of Hyperpolarized 13C Agents at 7 Tesla. ISMRM & SMRT Annual Meeting:3800, 2021. e-Pub 2021.
Mitcham T, Nevozhay D, Chen Y, Kulp A, Nguyen L, Lai S, Sokolov K, Bouchard R. In Vivo Imaging and Activation of Perfluorohexane Nanodroplets with High-Frequency Ultrasound. Proceedings of the 2021 IEEE Ultrasonics Symposium, 2021. e-Pub 2021.
Fan B, Goodman W, Cho R, Sheth S, Bouchard R, Aazhang B. Beamforming Design for High-Resolution Low-Intensity Focused Ultrasound Neuromodulation. Proceedings of the 2020 IEEE International Conference on Acoustics, Speech, and Signal Processing, 2020. e-Pub 2020.
Mitcham T, Nevozhay D, Schwartz-Duval A, Lai S, Sokolov K, Bouchard R. High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets. SPIE Medical Imaging 11319:113190Q, 2020. e-Pub 2020.
Wood C, Kim CS, Han S, Wen Y, Kaffes C, Cook J, Sood A, Sokolov K, Bouchard R. Molecularly targeted Lipo-JICG for in vivo quantitative photoacoustic imaging. SPIE Medical Imaging 11319:1131902, 2020. e-Pub 2020.
Wood C, Han S, Schuler W, Cook J, Pagel M, Sokolov K, Bouchard R. In vivo quantitative photoacoustic imaging with PAtrace in TNBC model. Proceedings of the 2020 IEEE Ultrasonics Symposium, 2020. e-Pub 2020.
Mitcham T, Nevozhay D, Lee S, Lai S, Sokolov K, Bouchard R. Optimization of High-Frequency-Ultrasound Imaging and Activation of High Boiling Point Activatable Perfluorocarbon Nanodroplets in a Tissue-Mimicking Phantom. Proceedings of the 2020 IEEE Ultrasonics Symposium, 2020. e-Pub 2020.
Mitcham T, Nevozhay D, Lai S, Sokolov K, Bouchard R. Nonlinear Ultrasound Imaging of Phase-Change Perfluorocarbon Nanodroplets Activated by High-Frequency Ultrasound in a Tissue-Mimicking Environment. American Association of Physicists in Medicine 61st Annual Meeting and Exhibition 46(6):E468, 2019. e-Pub 2019.
Wood C, Kim C, Han S, Naser M, Kaffes C, Cook J, Sood A, Sokolov K, Bouchard R. Quantitative Photoacoustic Imaging for the Assessment of Targeted LipoJICG in a Preclinical Model. American Association of Physicists in Medicine 61th Annual Meeting and Exhibition 46(6):E132, 2019. e-Pub 2019.
Bohndiek B, Brunker J, Grohl J, Krebsforschungszentrum D, Hacker L, Joseph J, Vogt WC, Armanetti P, Assi H, Bamber JC, Paul C Beard PC, Thomas Berer T, Bouchard R, Briggman KA, Cavigli L, Clingman B, Cox BT, Desjardins AE, Heinmiller A, Hwang J, Hysi E, Ivory A, Jose J, Kirchner T, Klohs J, Lena Maier-Hein L, Maneas E, Mannheim J, Manohar S, McNally L, Menichetti L, Miller S, Morscher S, Ni R, Yoko Okamura Y, Malini C Olivo MC, Pagel M, Parker G, Pelagotti A, Pifferi A, Rajagopal S, Razansky D, Richards LM, Ron A, Singh MKA, Waldner M, Alexander F, Wang K, Wang LV, Xia W, Zeqiri B. Photoacoustic Standardisation Consortium (IPASC): overview. SPIE Photonics West 10878:108781N, 2019. e-Pub 2019.
Wood C, Kim C, Han S, Wen Y, Naser M, Kaffes C, Cook J, Sood A, Sokolov K, Bouchard R. In vivo quantitative photoacoustic imaging of targeted Lipo-JICG. Proceedings of the 2019 IEEE Ultrasonics Symposium, 2019. e-Pub 2019.
Bouchard R, Wood C, Kim CS, Wen Y, Cook J, Sood A, Sokolov K. Liposome-encapsulated ICG dye J-aggregates for molecular photoacoustic imaging of ovarian cancer. World Molecular Imaging Congress, 2019. e-Pub 2019.
Mokhlis HA, Bayraktar R, Kabil NN, Kahraman N, Bouchard R, Abdelghany T, Ashour A, Abdel-Aziz AH, Calin GA, Lopez-Berestein G, Ozpolat B. MiR-873 functions as a potential tumor suppressor in pancreatic cancer by targeting KRAS. ACCR Annual Meeting 78(13):507, 2018. e-Pub 2018.
Wood C, Harutyunyan K, Delacerda J, Kaffes C, Zacharias Millward N, Shanmugavelandy S, Konopleva M, Bouchard R. Optimization of a Spectroscopic Photoacoustic Imaging Technique to Noninvasively Assess Oxygen Saturation in Murine Femoral Bone Marrow. American Association of Physicists in Medicine 60th Annual Meeting and Exhibition 45(6):E392-E393, 2018. e-Pub 2018.
Mitcham T, Nevozhay D, Vilardo C, Lai S, Sokolov K, Bouchard R. Ultrasound Activatable Nanodroplets Targeted to EGFR for Molecular Imaging with High-Frequency Ultrasound. American Association of Physicists in Medicine 60th Annual Meeting and Exhibition 45(6):E569, 2018. e-Pub 2018.
Wood C, Harutyunyan K, Delacerda J, Kaffes C, Zacharias Millward N, Shanmugavelandy S, Konopleva M, Bouchard R. Assessment of blood oxygen saturation using spectroscopic photoacoustic imaging as a biomarker for disease progression in a small-animal leukemia model. SPIE Medical Imaging 10580:190-197, 2018. e-Pub 2018.
Naser M, Munoz N, Sampaio DRT, Taghavi H, Mitcham T, Maldonado K, Kingsley C, Avritscher R, Bouchard R. Imaging biomarker development based on microbubble perfusion and oxygen saturation in a rat model of liver cancer. SPIE Medical Imaging 10580:14-23, 2018. e-Pub 2018.
Mitcham T, Nevozhay D, Vilardo C, Lai S, Sokolov K, Bouchard R. High-frequency molecular ultrasound imaging using targeted phase-change nanodroplets. Proceedings of the 2018 IEEE Ultrasonics Symposium, 2018. e-Pub 2018.
Sampaio D, Hess J, Naser M, Mitcham T, Wood C, Pavoni, Pavan T, Bouchard R. Removing Noise Bias in Photoacoustic-Based SO2 Estimates: A Simple Empirical SNR-Adaptive Thresholding Approach. American Association of Physicists in Medicine 60th Annual Meeting and Exhibition 45(6):E568-E569, 2018. e-Pub 2018.
Harutyunyan K, Konopleva M, Mallampati S, Rytelewski R, Zal T, Wood C, Bouchard R. Interaction of Leukemia and Bone Marrow Microenvironment in Mouse ALL Model is Associated with Disorganized Vasculature and Progressive Hypoxia. Proceedings of the Society of Hematologic Oncology Annual Meeting 17:S259-S260, 2017. e-Pub 2017.
Bhansali D, Paulsen S, Mitcham T, Grigoryan B, Stefan W, Miller J, Bouchard R. Quantitative Assessment of Ultrasound Backscatter in 3D Printed Phantoms. Biomedical Engineering Society. BMES National Conference, 2017. e-Pub 2017.
Paulen SJ, Long J, Mitcham T, Grigoryan B, Stefan W, Miller JS, Bouchard R. Quantitative 3D assessment of flow in a printed hydrogel vascular phantom. 42nd International Symposium on Ultrasonic Imaging and Tissue Characterization, 2017. e-Pub 2017.
Taghavi H, Munoz N, Naser M, Maldonado K, Kingsley C, Tang Y, Okafor E, Avritscher R, Bouchard R. Photoacoustic-ultrasonic imaging biomarkers for treatment-response assessment of sorafenib in a rat model of hepatocellular carcinoma. Proceedings of the 2017 IEEE Ultrasonics Symposium, 2017. e-Pub 2017.
Paulen SJ, Long J, Mitcham T, Grigoryan B, Bhansali D, Stefan W, Miller JS, Bouchard R. Quantitative 3D assessment of flow in a printed hydrogel vascular phantom. Proceedings of the 2017 IEEE Ultrasonics Symposium, 2017. e-Pub 2017.
Naser M, Taghavi H, Munoz N, Maldonado K, Kingsley C, Avritscher R, Bouchard R. SO2 quantification of rat HCC tumors using fluence-corrected photoacoustic imaging. Proceedings of the 2017 IEEE Ultrasonics Symposium, 2017. e-Pub 2017.
Han S, Emelianov S, Bouchard R, Sokolov K. Ultra-small Plasmonic NanoSensors for Cancer Theranostics. Cancer Nanotechnology Gordon Research Conference, 2017. e-Pub 2017.
Benenuto, N, Taghavi, H, Mitcham, T, Cressman, E, Sheth, R, Bouchard R. Real-time monitoring of tumor-specific indocyanine green hepatic photothermal ablation using photoacoustic imaging. Society of Interventional Radiology Annual Meeting, 2017. e-Pub 2017.
Wood C, Harutyunyan K, Delacerda J, Kaffes C, Zacharias Millward N, Shanmugavelandy S, Konopleva M, Bouchard R. Photoacoustic-based SO2 assessment of femoral bone marrow in a murine model of leukemia. Proceedings of the 2017 IEEE Ultrasonics Symposium, 2017. e-Pub 2017.
Wood C, Harutyunyan K, Delacerda J, Kaffes C, Zacharias Millward N, Shanmugavelandy S, Konopleva M, Bouchard R. Photoacoustic-based SO2 assessment of femoral bone marrow in a murine model of leukemia. World Molecular Imaging Congress, 2017. e-Pub 2017.
Moaseri E, Han S, Chang B, Truskett T, Emelianov S, Bouchard R, Johnston K, Sokolov K. Biodegradable nanoclusters for molecular cancer imaging and therapy. Cancer Nanotechnology Gordon Research Conference, 2017. e-Pub 2017.
Mitcham, T, Taghavi, H, Fuentes D, Ward J, Hobbs B, Bouchard R. Assessment of photoacoustic-based sO2 estimation in an excised prostate. 41st International Symposium on Ultrasonic Imaging and Tissue Characterization, 2016, 2016. e-Pub 2016.
Mitcham, T, Taghavi, H, Fuentes D, Ward J, Hobbs B, Bouchard R. Photoacoustic SO2 estimation with fluence correction in an interstitially irradiated excised prostate. Proceedings of the 2016 IEEE Ultrasonics Symposium, 2016. e-Pub 2016.
Mitcham T, Melancon A, Eggers M, Bouchard R, Melancon M. Ultrasound Imaging of Absorbable Inferior Vena Cava Filters for Proper Placement. American Association of Physicists in Medicine 58th Annual Meeting and Exhibition, 2016. e-Pub 2016.
Bouchard R, Guha S, Mitcham T, Shaw G, Smith B. Ratiometric Photoacoustic Imaging of Acidic pH. Proceedings of the 2015 IEEE Ultrasonics Symposium, 2015, 2015. e-Pub 2015.
Shea LAG, Dextraze K, Mitcham TM, Gray JP, Bouchard RR, Cressman ENK. Photoacoustic Ultrasound-Guided Real-Time Imaging of Thermochemical Ablation in Ex Vivo Porcine Liver. Society of Interventional Radiology Annual Scientific Meeting, 2015. e-Pub 2015.
Melancon MP, Qiao Y, Gumin J, Maclellan C, Wallace M, Bouchard R, Lang F, Stafford RJ. Magnetic resonance and photoacoustic imaging for treatment planning of brain tumor mediated by mesenchymal stem cell-labeled with multifunctional nanoparticle. 4th International Conference on Multifunctional, Hybrid and Nanomaterials, 2015, 2015. e-Pub 2015.
Dextraze K, Munoz-Gonzalez N, Heinmiller A, Bankson J, Kingsley C, Michel K, Avritscher R, Bouchard R. Mapping Oxygen Saturation in the Tumor Microenvironment via Photoacoustic-Ultrasonic Imaging. CPRIT Innovations in Cancer Research Conference, 2015, 2015. e-Pub 2015.
Dextraze K, Munoz-Gonzalez N, Heinmiller A, Bankson J, Kingsley C, Michel K, Avritscher R, Bouchard R. Ultrasonic-based tissue oxygen saturation and perfusion assessment in a rat orthotopic liver tumor model. 40th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2015, 2015. e-Pub 2015.
Dextraze K, Munoz-Gonzalez N, Huang S, Figueira T, Heinmiller A, Avritscher R, Bouchard R. Photoacoustic assessment of spatially and temporally varying oxygen saturation and perfusion in an orthotopic rat model of human hepatocellular carcinoma. Proceedings of the 2015 IEEE Ultrasonics Symposium, 2015, 2015. e-Pub 2015.
Mitcham T, Guha S, Dextraze K, Lee A, Sokolov K, Smith B, Bouchard R. Environmentally-sensitive contrast agents for photoacoustic imaging of cancer cells. 40th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2015, 2015. e-Pub 2015.
Gray J, Dana N, Maier F, Ege O, Mitcham T, Stafford J, Emelianov S, Bouchard R. Use of multi-wavelength photoacoustic imaging to distinguish HIFU ablation lesions. SPIE Photonics West 2015, 2015. e-Pub 2015.
Lee A, Dextraze KL, Luke GP, Emelianov SY, Bouchard RR, Sokolov KV. Ratiometric cellular sensor based on J-aggregate trapping in liposomes. SPIE Photonics West, 2015, 2015. e-Pub 2015.
Bouchard R, Wolfe T, Thornton M, Morgan T, Mitcham T, Bhattarai S, Grant J, Lee J, Hazle J, Krishnan S. Three-dimensional in vivo photoacoustic tracking of targeted nanoparticles in a pancreatic cancer model. American Association for Cancer Research 74(19):2051, 2014. e-Pub 2014.
Mitcham T, Lynch J, Cook J, Emelianov S, Bouchard R. Development and Characterization of a Temporally Stable Tissue-Mimicking Photoacoustic-Ultrasonic Phantom. American Association of Physicists in Medicine 56th Annual Meeting and Exhibition 41:135, 2014. e-Pub 2014.
Emelianov S, Hall T, Bouchard RR. Ultrasound Elasticity. American Association of Physicists in Medicine 56th Annual Meeting and Exhibition 41:502, 2014. e-Pub 2014.
Dextraze K, MacLellan C, Mitcham T, Melancon M, Bouchard R. Development of a Thermally Stable Phantom for Photoacoustic and Magnetic Resonance Temperature Imaging. American Association of Physicists in Medicine 56th Annual Meeting and Exhibition 41:447-448, 2014. e-Pub 2014.
Gray J, Dana N, Maier F, Ege O, Mitcham T, Stafford J, Emelianov S, Bouchard R. Assessment of HIFU-induced tissue damage using multi-wavelength photoacoustic imaging. Proceedings of the 2014 IEEE Ultrasonics Symposium, 2014. e-Pub 2014.
Mitcham T, Dextraze K, Karipouk A, Singhana B, Melancon M, Bouchard R. Increasing the penetration depth of clinical photoacoustic imaging with interstitial irradiation. 39th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2014. e-Pub 2014.
Bouchard R, Thornton M, Dextraze K, Morgan T, Grant J, Krishnan S. Coregistered photoacoustic perfusion assessment and targeted nanoparticle tracking in a prostate cancer model. 39th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2014. e-Pub 2014.
Dextraze KL, Gray JP, MacLellan C, Mitcham TM, Melancon MP, Bouchard RR. Expanding the clinical role of photoacoustic imaging: thermography and spectroscopy for guiding thermal ablation. 39th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2014. e-Pub 2014.
Dana N, Bouchard RR, Di Biase L, Natale A, Emelianov SY. Characterization of myocardial ablation lesions using multi-wavelength photoacoustic imaging. SPIE Photonics West, 2014. e-Pub 2014.
Mitcham T, Marques T, Chatterjee D, Krishnan S, Pugh T, Bouchard R. Transrectal photoacoustic-ultrasonic imaging for cancer diagnosis and therapy guidance in the prostate. 38th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2013. e-Pub 2013.
Bouchard R, MacLellan C, Mitcham T, Oguzhan E, Lee H, Stafford J, Melancon M. Nanoparticle-mediated photothermal tumor therapy monitored with photoacoustic and magnetic resonance thermometry. Proceedings of the 2013 IEEE Ultrasonics Symposium, 2013. e-Pub 2013.
Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Wallace M, Li C, Gupta S, Melancon M. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with Doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. 38th Society of Interventional Radiology Annual Scientific Meeting, 2013. e-Pub 2013. PMID: 23920038.
Dana N, Bouchard RR, Di Biase L, Natale A, Emelianov SY. 3-D Assessment of Myocardial Ablation Lesions using Ultrasound-guided Multi-wavelength Photoacoustic Imaging. 34th Heart Rhythm Society Annual Scientific Meeting, 2013. e-Pub 2013. PMID: 24080065.
Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Fukudac T, Mitchem TM, Cox PJ, Bouchard RR, Maekawa T, Kumar S, Mani SA, Ajayan PM. Fluorinated graphene oxide (F-GO) – a new multimodal material for biological applications. 16th Nanotechnology Conference and Expo, 2013. e-Pub 2013.
Mitcham T, Marques T, Chatterjee D, Krishnan S, Pugh T, Bouchard R. Transrectal photoacoustic-ultrasonic imaging enhancement through interstitial irradiation and targeted nanoparticles. Proceedings of the 2013 IEEE Ultrasonics Symposium, 2013. e-Pub 2013.
Bouchard RR, Cook JR, Emelianov SY. Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging. SPIE Photonics West, 2012. e-Pub 2012.
Bouchard RR, Homan K, Frey W, Chen Y, Emelianov SY. Modification of metallic surfaces for photoacoustic signal enhancement. Proceedings of the 2012 IEEE Ultrasonics Symposium, 2012. e-Pub 2012.
Bouchard RR, Dana N, Di Biase L, Natale A, Emelianov SY. Photoacoustic characterization of radiofrequency ablation lesions. SPIE Photonics West 8223:82233K, 2012. e-Pub 2012.
Hsu SJ, Bradway DP, Bouchard RR, Hollender PJ, Wolf PD, Trahey GE. Parametric pressure-volume analysis and acoustic radiation force impulse imaging of left ventricular function. Proceedings of the 2010 IEEE Ultrasonics Symposium:698-701, 2011. e-Pub 2011.
Bouchard RR, Su JL, Hazle JD, Emelianov SY. Quantitative Assessment of Photoacoustic and Ultrasonic Imaging of Prostate Brachytherapy Seeds. Proceedings of the 2011 IEEE Ultrasonics Symposium,, 2011. e-Pub 2011.
Hollender PJ, Bouchard RR, Trahey GE. Rapid acquisition of ARFI-induced shear-wave velocity estimates using temporally-interleaved displacement tracking. 36th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2011. e-Pub 2011.
Hollender PJ, Hsu SJ, Bouchard RR, Bradway DP, Wolf PD, Trahey GE. Intracardiac Measurements of Elasticity using Acoustic Radiation Force Impulse (ARFI) Imaging: Temporal and Spatial Stability. Proceedings of the 2010 IEEE Ultrasonics Symposium:682-685, 2010. e-Pub 2010.
Bouchard RR, Hsu SJ, Palmeri ML, Rouze NC, Trahey GE. ARF-Driven Assessment of In Vivo Myocardial Cyclic Stiffness Variation. 9th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 2010. e-Pub 2010.
Bouchard RR, Maimon B, Haughton D, Long Y, Hsu SJ, Trahey GE. In vivo and in vitro investigation of shear wave velocity anisotropy in myocardial tissue. 35rd International Symposium on Ultrasonic Imaging and Tissue Characterization, 2010. e-Pub 2010.
Hollender PJ, Hsu SJ, Bouchard RR, Bradway DP, Wolf PD, Trahey GE. Elasticity measurements through the cardiac cycle using acoustic radiation force impulse imaging (ARFI) on an intracardiac echocardiography (ICE) transducer. 35rd International Symposium on Ultrasonic Imaging and Tissue Characterization, 2010. e-Pub 2010.
Bouchard RR, Hsu SJ, Palmeri ML, Rouze NC, Trahey GE. Acoustic radiation force-driven assessment of myocardial elasticity. 35rd International Symposium on Ultrasonic Imaging and Tissue Characterization, 2010. e-Pub 2010. PMID: 21645966.
Hsu SJ, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. On the Characterization of Left Ventricular Function with Acoustic Radiation Force Impulse Imaging. 2009 IEEE International Ultrasonics Symposium:1942-1945, 2009. e-Pub 2009.
Trahey GE, Dahl JJ, Hsu SJ, Dumont DM, Bouchard RR, Allen J, Wolf PD. Acoustic Radiation Force Impulse Imaging of Cardiovascular Imaging. 2009 IEEE International Ultrasonics Symposium:163-168, 2009. e-Pub 2009.
Bouchard RR, Wolf PD, Hsu SJ, Dumont DM, Trahey GE. Acoustic Radiation Force-Induced Shear Wave Propagation in Cardiac Tissue. Medical Imaging 2009: Ultrasonic Imaging and Signal Processing 7265:330-337, 2009. e-Pub 2009.
Bouchard RR, Streeter JE, Palmeri ML, Dayton PA. Optical Quantification of Acoustic Radiation Force Impulse-Induced Dynamics in a Translucent Phantom. 2009 IEEE International Ultrasonics Symposium:1868-1870, 2009. e-Pub 2009.
Bouchard RR, Streeter JE, Palmeri ML, Dayton PA. Quantifying Acoustic Radiation Force Impulse-Induced Dynamics through Optical Methods: Experimental and Simulation Results,. 8th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 2009. e-Pub 2009.
Bouchard RR, Hsu SJ, Subramanian V, Wolf PD, Trahey GE. Temporal and Spatial Stability of Acoustic Radiation Force-Driven Shear Wave Velocimetry in Myocardial Tissue In Vivo. 8th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 2009. e-Pub 2009.
Bouchard RR, Streeter JE, Palmeri ML, Trahey GE, Dayton PA. Optical Tracking of Acoustic Radiation Force Impulse-Induced Dynamics in a Tissue-Mimicking Phantom. 157th Meeting of the Acoustical Society of America, 2009. e-Pub 2009.
Zhai L, Hsu SJ, Bouchard RR, Nightingale KR. A Combined ARFI Sequence for 2D Displacement Imaging and Shear Wave Velocity Mapping. IEEE Ultrasonics Symposium:2013-2016, 2008. e-Pub 2008.
Hsu SJ, Wolf PD, Dumont DM, Bouchard RR, Byram BC, Eyerly SA, Li Y, Trahey GE. Acoustic Radiation Force Impulse Imaging of Myocardial Performance, Initial In Vivo Results. 7th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 2008. e-Pub 2008.
Bouchard RR, van Soest G, van der Steen AFW. Combined Optical and Ultrasound-Based Tracking of an Acoustic Radiation Force-Induced Excitation. BMES Annual Fall Meeting, 2008. e-Pub 2008.
Bouchard RR, Wolf PD, Hsu SJ, Dumont DM, Trahey GE. In Vivo Investigation of Radiation Force-Induced Shear Wave Propagation in Myocardial Tissue. 7th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 2008. e-Pub 2008.
Nightingale KR, Palmeri ML, Zhai L, Wang MH, Rouze NC, Frinkley KD, Bradway DP, Dahl JJ, Hsu SJ, Dumont DM, Bouchard RR, Trahey GE. Acoustic radiation force impulse imaging: optimization for clinical applications. 33rd International Symposium on Ultrasonic Imaging and Tissue Characterization, 2008. e-Pub 2008.
Bouchard RR, Hsu SJ, Zhai L, Dahl JJ, Ong CW, Trahey GE. Advanced Pulse Sequences for ARFI Imaging. 33rd International Symposium on Ultrasonic Imaging and Tissue Characterization, 2008. e-Pub 2008. PMID: 18939611.
Bouchard RR, van Soest G, van der Steen AFW. Combined Optical and Ultrasound-Based Tracking of an Acoustic Radiation Force-Induced Excitation. 2007 IEEE Ultrasonics Symposium:444-447, 2007. e-Pub 2007.
Hsu SJ, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. In vivo Acoustic Radiation Force Impulse Imaging of the Cardiac Cycle. 2006 IEEE Ultrasonics Symposium:756-759, 2007. e-Pub 2007.
Dahl JJ, Bouchard RR, Palmeri ML, Agrawal V, Trahey GE. Parallel Tracking and Other Methods for Real-Time ARFI Imaging Systems. 2006 IEEE Ultrasonics Symposium:1005-1008, 2007. e-Pub 2007.
Van Soest G, Bouchard RR, Mastik F, de Jong N, van der Steen AFW. Robust intravascular optical coherence elastography driven by acoustic radiation pressure. European Conference on Biomedical Optics 6627:6627_13, 2007. e-Pub 2007.
Bouchard RR, Dahl JJ, Trahey GE. Image quality, tissue heating and frame-rate trade-offs in ARFI imaging. 31st International Symposium on Ultrasonic Imaging and Tissue Characterization, 2006. e-Pub 2006.
Zhai L, Palmeri ML, Bouchard RR, Nightingale RW, Nightingale KR. A finite element model of an integrated indenter/acoustic radiation force impulse (ARFI) imaging system. 31st International Symposium on Ultrasonic Imaging and Tissue Characterization, 2006. e-Pub 2006.
Hsu, SJ, Bouchard RR, Dumont DM, Wolf PD, Trahey GE. Preliminary Investigations into Realtime Cardiac Acoustic Radiation Force Impulse Imaging. 31st International Symposium on Ultrasonic Imaging and Tissue Characterization, 2006. e-Pub 2006.
Trahey GE, Pinton GF, Palmeri ML, Bouchard RR, Dahl JJ. Issues in real-time acoustic radiation force impulse imaging. 4th International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 2005. e-Pub 2005.
Zhai L, Bouchard RR, Palmeri ML, Nightingale RW, Nightingale KR. A combined indenter/ARFI imaging system. 2005 IEEE Ultrasonics Symposium, 2005. e-Pub 2005.
Nightingale KR, Palmeri ML, Bouchard RR, Trahey GE. Acoustic radiation force impulse imaging: a parametric analysis of factors affecting image quality. IEEE Symposium on Ultrasonics, 2003 1:548-553, 2003. e-Pub 2003.
Nightingale KR, Palmeri ML, Stutz DL, Fahey BJ, Bouchard RR, Trahey GE. Optimization of imaging parameters for acoustic radiation force impulse imaging. 28th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2003. e-Pub 2003.
Bouchard RR, Nightingale KR. Development and FEM Modeling of ARFI-based phantoms. Triangle Undergraduate Research Symposium, 2003. e-Pub 2003.
Stutz DL, Trahey GE, Palmeri ML, Bouchard RR, Nightingale KR. Measuring and modeling relaxation in viscoelastic phantoms with ARFI imaging. 28th International Symposium on Ultrasonic Imaging and Tissue Characterization, 2003. e-Pub 2003.

Book Chapters

Nevozhay D, Bouchard R, Sokolov K. Photoacoustic Imaging with Plasmonic Particles. In: Plasmonics in Diagnostics and Therapy, 2022.
Zhou M, Lui L, Yao J, Bouchard R, Wang LV, Li C. Photoacoustic Imaging of Vasculature. In: Applications of Nanoparticles in Biomedical Imaging. Springer, 2016.
Rosenzweig S, Bouchard R, Polascik T, Zhai L, Nightingale K. Prostate Elastography and Photoacoustic Imaging. In: Image-Guided Prostate Cancer Treatments. Springer, 2014.
Aglyamov S, Bouchard RR, Graf IM, Emelianov SY. Breast Elasticity Imaging. In: Physics of Mammographic Imaging. Taylor & Franics, 2012.

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CV information above last modified July 30, 2025

Richard R. Bouchard, Ph.D.

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Richard R. Bouchard, Ph.D.

About Dr. Richard R. Bouchard

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Research Interests

Education & Training

Degree-Granting Education

Postgraduate Training

Experience & Service

Faculty Academic Appointments

Administrative Appointments/Responsibilities

Other Professional Positions

Institutional Committee Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

Local Presentations

Regional Presentations

National Presentations

International Presentations

Formal Peers

Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Review Articles

Other Articles

Abstracts

Book Chapters

Patient Reviews

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