Rick R. Layman, Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
About Dr. Rick R. Layman
I have worked for many years as a Board Certified Medical Physicist where I have developed translational techniques and optimized imaging methodologies to improve patient diagnosis and characterization of disease. It was during my doctorate work that I critically investigated quantitative molecular imaging methods with the goal to develop non-invasive techniques for accurate imaging based approaches. I specifically studied a targeted theranostic agent 68Ga/177LuAMBA and developed quantitative molecular imaging (PET/CT and SPECT/CT) methods based on attenuation correction, co-registration, and post-processing. Since joining UT MD Anderson, I have focused on advanced dual-energy CT (DECT) and photon counting detector CT (PCD-CT). This has included the development of clinical protocols and validation for diagnostic interpretation. My research has more specifically focused on quantitative CT to explore unique biomarkers for characterization of oncologic disease and response to therapy.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Member, Department of Medical Physics, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX
Adjunct Assistant Professor, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Member, Department of Medical Physics, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX
Adjunct Assistant Professor, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH
Research Interests
Quantitative imaging focused on multi-energy CT with PCD-CT and DECT
Clinical Interests
.
Education & Training
Degree-Granting Education
| 2013 | The Ohio State University, Columbus, Ohio, US, Biophysics, Ph.D |
| 2000 | John Carroll University, University Heights, Ohio, US, Chemistry, M.S |
| 1997 | Case Western Reserve University, Cleveland, Ohio, US, Chemistry and Environmental Geology, B.A |
Board Certifications
| 2004 | American Board of Radiology, Diagnostic Medical Physics |
Experience & Service
Academic Appointments
Assistant Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2019
Assistant Professor, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, 2013 - 2016
Instructor, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, 2008 - 2013
Administrative Appointments/Responsibilities
Chair, Residency Admissions Committee, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2022
Residency Clinical Coordinator, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2022
Director, Faculty Development, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2022
Vice Chair, Institutional Review Board, Department of Committee 4, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2020 - 2022
Chief, Division of Imaging Physics, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, 2013 - 2016
Chair, Radiation Safety and Quality Committee, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, 2010 - 2016
Chair, ALARA Subcommittee, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, 2010 - 2016
Chair, Computed Tomography Quality Assurance Committee, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, 2009 - 2016
Diagnostic and Mammography Certified Radiation Expert, Radiation Safety Committee, The Ohio State University Wexner Medical Center, Columbus, Ohio, 2008 - 2016
Assistant Radiation Safety Officer, Radiation Safety Committee, William Beaumont Hospital, Royal Oak, Michigan, 2004 - 2008
Other Appointments/Responsibilities
Invited Member, Next Generation CT Advisory Board, GE Healthcare, Waukesha, WI, 2019 - Present
Invited Member, American Association of Physicists in Medicine (AAPM)/Ohio Department of Health (ODH) Regulatory Advisory Committee, Ohio Department of Health, Columbus, OH, 2012 - 2016
Institutional Committee Activities
Member, Committee 5, 2022 - Present
Vice Chair, Committee 4, 2020 - 2022
Member, Committee 3, 2020 - 2022
Co-Chair, Radiation Oncology Strategic Initiatives (ROSI), 2019 - 2020
Member, Committee 4, 2019 - 2022
Member, Academic Review Committee, 2019 - 2021
Member, Imaging Informatics Work Group, 2010 - 2016
Chair, Radiation Safety and Quality Committee, 2010 - 2016
Chair, ALARA Subcommittee, 2010 - 2016
Member, Radiology Safety and Risk Reduction Committee, 2010 - 2016
Member, Imaging Technology Assessment and Resource Assessment Committee, 2010 - 2016
Member, Imaging Compliance, Accreditation, and Credentialing Committee, 2010 - 2016
Chair, Computed Tomography Quality Assurance Committee, 2009 - 2016
Diagnostic Certified Radiation Expert Designee, Radiation Safety Committee, 2008 - 2016
Assistant Radiation Safety Officer, Radiation Safety Committee, 2004 - 2008
Honors & Awards
| 2022 | Fellow, American Association of Physicist in Medicine |
| 2022 | Michael D. Mills Editor in Chief Award of Excellence for an Outstanding General Medical Physics Article, Journal of Applied Clinical Medical Physics |
| 2018 | BEST IN PHYSICS (IMAGING) abstract selected at the annual meeting, American Association of Physicists in Medicine |
| 1999 | Graduate Teaching Assistant Award, John Carroll University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Thomas MA, Jacobsen MC, Jensen CT, Wagner-Bartak NA, Ahmad M, Layman RR. Quantifying the Performance of Enhanced Radiation Output, Dual-Source CT Relative to Traditional CT in Patients With Severe Obesity. J Comput Assist Tomogr, 2025. e-Pub 2025. PMID: 40568947.
- Govyadinov P, Layman RR, Netherton T, Mumme R, Jones AK, Court LE, Ahmad M. Robust automated method of spatial resolution measurement in radiotherapy CT simulation images. J Appl Clin Med Phys 26(3):e70006, 2025. e-Pub 2025. PMID: 39946267.
- Melancon AD, Jacobsen M, Damasco J, Perez J, Bernardino M, Valentin ES, Court KA, Godin B, Layman RR, Melancon MP. Correction for Partial Volume Averaging in the Quantification of Radiopaque Nanomaterial-Embedded Resorbable Polymers. Biomed Phys Eng Express. e-Pub 2024. PMID: 39094587.
- Layman RR, Leng S, Boedeker KL, Burk LM, Dang H, Duan X, Jacobsen MC, Li B, Li K, Little K, Madhav P, Miller J, Nute JL, Giraldo JCR, Ruchala KJ, Tao S, Varchena V, Vedantham S, Zeng R, Zhang D. AAPM Task Group Report 299: Quality control in multi-energy computed tomography. Med Phys, 2024. e-Pub 2024. PMID: 39072826.
- San Valentin EM, Damasco JA, Bernardino M, Court KA, Godin B, Canlas GM, Melancon A, Chintalapani G, Jacobsen MC, Norton W, Layman RR, Fowlkes N, Chen SR, Huang SY, Melancon MP. Image-guided deployment and monitoring of a novel tungsten nanoparticle-infused radiopaque absorbable inferior vena cava filter in a swine model. J Vasc Interv Radiol 35(1):113-121.e3, 2024. e-Pub 2024. PMID: 37696432.
- Thompson EA, Jacobsen MC, Fuentes DT, Layman RR, Cressman ENK. Quantitative dual-energy computed tomography with cesium as a novel contrast agent for localization of thermochemical ablation in phantoms and ex vivo models. Med Phys 50(12):7879-7890, 2023. e-Pub 2023. PMID: 37409792.
- Thompson EA, Fowlkes NW, Jacobsen MC, Layman RR, Cressman ENK. Quantitative Dual-Energy Computed Tomography Image Guidance for Thermochemical Ablation: in vivo Results in the Rabbit VX2 Model. J Vasc Interv Radiol 34(5):782-789, 2023. e-Pub 2023. PMID: 36539151.
- San Valentin EM, Damasco JA, Bernardino M, Court KA, Godin B, Canlas GM, Melancon A, Chintalapani G, Jacobsen MC, Norton W, Layman RR, Fowlkes N, Chen SR, Huang SY, Melancon MP. Image-guided deployment and monitoring of a novel tungsten nanoparticleâ€"infused radiopaque absorbable inferior vena cava filter in pigs. bioRxiv, 2023. e-Pub 2023. PMID: 36798362.
- Damasco JA, Huang SY, Perez JVD, Manongdo JAT, Dixon KA, Williams ML, Jacobsen MC, Barbosa R, Canlas GM, Chintalapani G, Melancon AD, Layman RR, Fowlkes NW, Whitley EM, Melancon MP. Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs. ACS Biomater Sci Eng 8(4):1676-1685, 2022. e-Pub 2022. PMID: 35343679.
- Ramirez Cadavid DA, Layman RR, Nishino T, Slutzky JL, Li Z, Cornish K. Guayule Natural Rubber Latex and Bi2O3 Films for X-ray Attenuating Medical Gloves. Materials (Basel) 15(3), 2022. e-Pub 2022. PMID: 35161128.
- Layman RR, Hardy AJ, Kim HJ, Chou EN, Bostani M, Cagnon C, Cody D, McNitt-Gray M. A Comparison of Breast and Lung Doses from Chest CT Scans Using Organ-Based Tube Current Modulation (OBTCM) vs. Automatic Tube Current Modulation (ATCM). J Appl Clin Med Phys 22(5):97-109, 2021. e-Pub 2021. PMID: 33939253.
- Huang K, Rhee DJ, Ger R, Layman R, Yang J, Cardenas CE, Court LE. Impact of slice thickness, pixel size, and CT dose on the performance of automatic contouring algorithms. J Appl Clin Med Phys 22(5):168-174, 2021. e-Pub 2021. PMID: 33779037.
- Ahmad M, Jacobsen MC, Thomas MA, Chen HS, Layman RR, Jones AK. A Benchmark for automatic noise measurement in clinical computed tomography. Med Phys 48(2):640-647, 2021. e-Pub 2020. PMID: 33283284.
- Perez JVD, Jacobsen MC, Damasco JA, Melancon A, Huang SY, Layman RR, Melancon MP. Optimization of the differentiation and quantification of high-Z nanoparticles incorporated in medical devices for CT-guided interventions. Med Phys 48(1):300-312, 2021. e-Pub 2020. PMID: 33216978.
- Fuentes D, Thompson E, Jacobsen M, Crouch AC, Layman RR, Riviere B, Cressman E. Imaging-based characterization of convective tissue properties. Int J Hyperthermia 37(3):155-163, 2020. e-Pub 2020. PMID: 33426993.
- Huang SY, Damasco JA, Tian L, Lu L, Perez JVD, Dixon KA, Williams ML, Jacobsen MC, Dria SJ, Eggers MD, Melancon AD, Layman RR, Whitley EM, Melancon MP. In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model. Biomater Sci 8(14):3966-3978, 2020. e-Pub 2020. PMID: 32558854.
- Javadi S, Elsherif S, Bhosale P, Jensen CT, Layman RR, Jacobsen MC, Le O, Jia S, Parikh RJ, Tamm EP. Quantitative attenuation accuracy of virtual non-enhanced imaging compared to that of true non-enhanced imaging on dual-source dual-energy CT. Abdom Radiol (NY) 45(4):1100-1109, 2020. e-Pub 2020. PMID: 32052130.
- McCollough CH, Boedeker K, Cody D, Duan X, Flohr T, Halliburton S, Hsieh J, Layman R, Pelc NJ. Principles and Applications of Multi-energy CT Report of AAPM Task Group 291. Med Phys. e-Pub 2020. PMID: 32215937.
- Fuentes D, Fahrenholtz SJ, Guo C, MacLellan CJ, Layman RR, Rivière B, Stafford RJ, Cressman E. Mathematical modeling of mass and energy transport for thermoembolization. Int J Hyperthermia 37(1):356-365, 2020. e-Pub 2020. PMID: 32308071.
- Mujtaba B, Hanafy AK, Largo RD, Taher A, Madewell JE, Costelloe C, Layman RR, Morani AC. The lumbar artery perforator flap: clinical review and guidance on image reporting. Clin Radiol. e-Pub 2019. PMID: 31300211.
- Mujtaba B, Gu L, Largo RD, Amini B, Layman RR, Madewell JE, Costelloe CM. VIDEO: Preoperative CT Angiography for Scapula Osteocutaneous Free Flap Reconstructions. AJR Am J Roentgenol:W1-W2. e-Pub 2019. PMID: 31166756.
- MacLellan CJ, Layman RR, Geiser W, Gress DA, Kyle Jones A. Evaluation of an Automated Grid Artifact Detection System for Quality Control in Digital Mammography. Med Phys. e-Pub 2019. PMID: 31116445.
Invited Articles
- Vlahos I, Jacobsen MC, Godoy MC, Stefanidis K, Layman RR. Dual-energy CT in pulmonary vascular disease. Br J Radiol 95(1129):20210699, 2022. e-Pub 2022. PMID: 34538091.
- Jacobsen MC, Thrower SL, Ger RB, Leng S, Court LE, Brock KK, Tamm EP, Cressman ENK, Cody DD, Layman RR. Multi-energy computed tomography and material quantification: Current barriers and opportunities for advancement. Med Phys. e-Pub 2020. PMID: 32453879.
Abstracts
- Govyadinov P, Netherton TJ, Jones AK, Layman RR, Court LE, Ahmad MU. An automated method of spatial resolution measurement in radiotherapy CT simulation images. AAPM, 2023. e-Pub 2023.
- Wood CA, Jacobsen MC, Thompson EA, Layman RR. Verification of dual-energy CT calcium quantification accuracy in a phantom system. AAPM, 2023. e-Pub 2023.
- Michel KA, Sun P, Layman RR, Dong F. Helical CTDIvol measurement in practice: Effects of protocol factors for modern CT systems. AAPM, 2023. e-Pub 2023.
- Thompson EA, Jacobsen MC, Duan X, Wood CA, Layman RR. Validation of a Quality Control Phantom for Opportunistic Spectral CT Bone Mineral Density Quantification. AAPM, 2023. e-Pub 2023.
- Thompson E, Stolley D, Jacobsen M, Yu M, Pogostin B, Seeley E, Crouch A, Warar S, McHugh K, Layman RR, Cressman E. Alkaline Embolization In Vivo: Multi-Modal Feasibility Study using Computed Tomography, Fluoroscopy, and Mass Spectrometry Imaging. American Society for Mass Spectrometry, 2021. e-Pub 2021.
- Thompson E, Jacobsen M, Layman RR, Cressman E. Image Guidance in Thermochemical Ablation: An In Vivo Study with Quantitative Dual-Energy CT. International Congress for Hyperthermic Oncology, 2021. e-Pub 2021.
- Nan B, Rashiwala A, Krayyam A, Wang E, Pokhylevych H, Amer A, Alhasan H, Schellingerhout D, Ferguson S, Li J, Layman R, Johnson J. Optimizing Dual-Energy CT Virtual Monochromatic Energy and Contrast Timing to Maximize Brain Metastasis Conspicuity. The Eastern Neuroradiological Society Annual Conference, 2021. e-Pub 2021.
- Thompson E, Jacobsen M, Layman RR, Cressman E. Quantitative DECT for Image-Guided Thermochemical Ablation: An In Vivo Study. AAPM, 2021. e-Pub 2021.
- Thompson E, Jacobsen M, Layman RR, Cressman E. Quantitative Image Guidance In Vivo: Dual-Energy CT for Thermochemical Ablation. AAPM, 2021. e-Pub 2021.
- Thomas MA, Ahmad M, Jacobsen M, Wagner-Bartak N, Jensen C, Layman RR. Global noise analysis of single and dual source CT for obese patients. AAPM, 2021. e-Pub 2021.
- Ahmad M, Thomas A, Jacobsen M, Layman RR, Brock K. Optimization and Validation of an Automatic Noise Measurement Algorithm for Clinical CT Image Data. AAPM, 2020. e-Pub 2020.
- Thompson EA, Baluya DL, Crouch AC, Jacobsen MC, Layman RR, Whitley EM, Cressman ENK. Mass spectrometry imaging in cesium mapping for thermochemical ablation: correlation with dual-energy computed tomography. American Society for Mass Spectrometry, 2020. e-Pub 2020.
- Jacobsen M, Thompson E, Liu X, Odisio B, Cressman E, Layman RR. Comparison of IMAR and AiMAR Techniques for Metal Artifact Reduction in CT-Guided Microwave Ablations. AAPM, 2020. e-Pub 2020.
- Thompson E, Jacobsen M, Layman RR, Cressman E. Quantitative Image Guided DECT Interventions: A Potential New Theranostic for Thermochemical Ablation. AAPM, 2020. e-Pub 2020.
- Perez JV, Damasco J, Jacobsen M, Melancon A, Eggers M, Huang S, Layman RR, Melancon M. In Vivo Longitudinal Quantification of Radiopacity of a Nanoparticle-Infused Biodegradable Inferior Vena Cava Filter in a Porcine Model. AAPM, 2020. e-Pub 2020.
- Baluya D, Thompson E, Jacobsen M, Layman R, Whitley E, Cressman E. Multimodal Analysis through Mass Spectrometry Imaging and Multi-energy Tomography using Cesium as an Integrative Marker. American Society for Mass Spectrometry, 2019. e-Pub 2019.
- Fuentes D, Fahrenholtz S, Guo C, Thompson E, Jacobsen M, Layman RR, Stafford J, Cressman E. Mathematical model developments for thermoembolization. Society of Thermal Medicine, 2019. e-Pub 2019.
- Adebileje SA, Alexander SD, Amma MR, Anjomrouz M, Asghariomadad F, Atharifard A, Baer K, Bamford B, Carbonez P, Chambers C, Chernoglazov AI, Dahal S, Dalefield T, Damet J, de Ruiter NJA, Doesburg RMN, Duncan N, Gieseg SP, Goulter BP, Gurney S, Healy JL, Hilton PJ, Kanithi P, Kirkbride T, Lansley SP, Lowe C, Mandalika VBH, Marfo E, Matanaghi A, Moghiseh M, Plamer D, Panta RK, Prebble HM, Raja AY, Ramyar M, Renaud P, Schleich N, Searle E, Shamshad M, Shejja JS, Uddin R, Broeke LV, Walker EP, Walsh MF, Wijesooriya M, Woodfield TBF, Hagemeyer CE, Layman RR, Pourmorteza A, Pan D, Polydorides N, Chaudhari P. Soft tissue and nanoparticle imaging with MARS scanners. MARS Biomedical Imaging Workshop, 2019. e-Pub 2019.
- Baluya D, Thompson E, Jacobsen M, Layman R, Whitley E, Cressman E. Multimodal Analysis through Mass Spectrometry Imaging and Multi-energy Tomography using Cesium as an Integrative Marker. American Society for Mass Spectrometry, 2019. e-Pub 2019.
- Huang K, Rhee D, Ger R, Layman RR, Yang J, Cardenas C, Court L. Effects of CT image acquisition and reconstruction parameters on automatic contouring algorithms. AAPM, 2019. e-Pub 2019.
- Jacobsen M, Thompson E, Fahrenholtz S, Stafford J, Cressman E, Layman RR. Feasibility of CT thermometry of laser ablations in ex-vivo porcine liver. Society of Thermal Medicine, 2019. e-Pub 2019.
- Jacobsen M, Thompson E, Fahrenholtz S, Stafford RJ, Cressman E, Layman RR. Feasibility of CT Thermometry for Laser Ablation of Ex-vivo Porcine Liver. Society for Thermal Medicine, 2019. e-Pub 2019.
- Jacobsen MC, Cressman EN, Duan X, Cody DD, Schellingerhout D, Layman RR. Detecting iodine enhancement with dual-energy computed tomography: How low can we go?. AAPM, 2018. e-Pub 2018.
- Ger RB, Zhou S, Chi PCM, Lee HJ, Layman RR, Jones AK, Goff DL, Fuller CD, Howell RM, Li H, Stafford RJ, Court LE, Mackin DS. Reducing variability using CT protocol harmonization. SWAAPM, 2018. e-Pub 2018.
- Hardy A, Chou E, Layman RR, Cody DD, Bostani M, Cagnon CH, McNitt-Gray M. A comparison of lung and breast doses from CT scans using organ-based tube current modulation (TCM) vs. conventional attenuation-based TCM using Monte Carlo simulations. RSNA, 2018. e-Pub 2018.
- Javadi S, Elsherif SB, Bhosale PR, Layman RR, Sun J, Le O, Tamm E. Image quality and diagnostic value of virtual non-enhanced imaging compared to true non-contrast imaging in the dual-source dual-energy CT. RSNA, 2018. e-Pub 2018.
- MacClellan C, Geiser W, Layman RR, Gress D, Jones AK. BEST IN PHYSICS (IMAGING): Evaluation of an automated grid artifact detection system for quality control in digital mammography. AAPM, 2018. e-Pub 2018.
- Jacobsen MC, Duan X, Cody DD, Cressman EN, Schellingerhout D, Layman RR. Determination of the limit of detection for iodinated contrast agents with multi-energy computed tomography. The International Society of Photographic Instrumentation Engineers in Medical Imaging, 2018. e-Pub 2018.
- Ott L, Javadi S, Jia S, Bhosale P, Layman RR, Yang W, Tamm E. Dual energy computed tomography in prediction of metastatic adenopathy in pancreatic cancer. American Roentgen Ray Society, 2018. e-Pub 2018.
- Ger RB, Zhou S, Chi PCM, Lee HJ, Layman RR, Jones AK, Goff DL, Fuller CD, Howell RM, Li H, Stafford RJ, Mackin DS, Court LE. Harmonized CT protocols for high quality radiomics studies. AAPM, 2018. e-Pub 2018.
- Hardy A, Layman RR, Cody DD, Bostani M, Cagnon C, McNitt-Gray M. Comparing lung and breast doses of chest CT exams from organ-based tube current modulation (TCM) to conventional attenuation-based TCM. AAPM, 2018. e-Pub 2018.
- Baluya D, Thompson E, Guo C, Layman RR, Cressman E. Valproic acid as a theranostic agent: Computed tomography and mass spectrometry imaging of an imageable ablation agent with anti-tumor properties. American Society of Mass Spectrometry, 2018. e-Pub 2018.
- Jacobsen MC, Cressman EN, Duan X, Cody CC, Schellingerhout D Layman RR. Limits for detecting low concentrations of iodine with dual-energy computed tomography. RSNA, 2018. e-Pub 2018.
- Cressman EN, Guo C, Thompson E, Layman RR, Karbasian N. Real time quantitative CT monitoring of thermochemistry by novel application of CsOH. Society of Thermal Medicine, 2018. e-Pub 2018.
- Layman RR, Jacobsen M, Duan X, Schellingerhout D, Bhosale PR, Tamm E, Cody D. Quantitative multi-energy computed tomography: “How to” assure accuracy and develop a quality control program. RSNA, 2017. e-Pub 2017.
- Baluya D, Guo C, Layman RR, Cressman E. Feasibility studies in imaging mass spectrometry for evaluating thermoembolization, a new interventional oncology technique. American Society for Mass Spectrometry, 2017. e-Pub 2017.
- Hardy, AJ, Bostani, M, Cagnon C, Layman RR, Cody D, McNitt-Gray M. Examining the effects of lung and breast dose CT scans using an organ-based tube current modulation. RSNA, 2017. e-Pub 2017.
- Layman RR. Quantitative MECT material suppression. AAPM, 2017. e-Pub 2017.
- Guo C, Baluya D, Layman RR, Cressman E. Imaging mass spectrometry of image-guided drug delivery (IGDD) in thermochemical ablation. American Society for Mass Spectrometry, 2017. e-Pub 2017.
- Layman RR, Guo C, Fahrenholtz S, Baluya D, Cressman E. Theranostic Multiplexed Thermochemical Ablation (MTCA): Tracking dichloroacetate using multi-energy computed tomography. Society of Thermal Medicine, 2017. e-Pub 2017.
- Layman RR, Guo C, Fahrenholtz S, Baluya D, Cressman E. Multi-energy computed tomography (MECT) imaging of endovascular ablation: thermoembolization in an ex-vivo porcine kidney model. Society of Thermal Medicine, 2017. e-Pub 2017.
- Guo C, Fokt I, Fahrenholtz S, Layman RR, Priebe W, Cressman ENK. Alternatives to ethiodized oil in IR research: From biodiesel to radiopaque oily embolic agent. Society of Interventional Radiology, 2017. e-Pub 2017.
- Alsanea MM, Krugh K, Layman RR. Effects of metal on CT size-specific dose estimates. AAPM, 2016. e-Pub 2016.
- Layman RR, Aalberg JK, Chiappone GA, Greulich CG, Corrigan KJ, White RD. Advantages of a state-of-the-art dual source computed tomography (DSCT) system in an ED setting. RSNA, 2015. e-Pub 2015.
- Wright CL, Layman RR, Kumar K, Kothandaraman S, Hall NC, Knopp MV, Tweedle M. Buckeye-Boost: Cerenkov luminescence amplification by the wavelength-shifting Ohio Buckeye extract, esculin. Society of Nuclear Medicine and Molecular Imaging, 2015. e-Pub 2015.
- Chiappone GA, Layman RR, Greulich C, Aalberg JK, Corrigan KJ, White RD. Quality improvement: CT gated thoraco-abdominal aortic CTAs utilizing state-of-the-art dual source technology. RSNA, 2015. e-Pub 2015.
- Lionberg A, Khayat M, Pan J, Rikabi AA, Al Taani J, Layman RR, Dowell JD. Advanced stage breast cancer is associated with catheter-tip thrombus formation following subcutaneous chest port placement. Society of Interventional Radiology, 2015. e-Pub 2015.
- Wright CL, Layman RR, Tweedle MF, Knopp MV, Hall NC. Scintigraphic bremsstrahlung and PET-derived assessment of yttrium-90 lung shunt fraction using a multi-compartment phantom model. Computer Assisted Radiology and Surgery, 2014. e-Pub 2014.
- Binzel K, Zhang J, Liu X, Layman RR, Knopp M, Hall NC, Knopp MV. Impact of current technologies (TOP, PSF, solid state detector) on the quantitative accuracy of PET/CT. Society of Nuclear Medicine, 2014. e-Pub 2014.
- Scansen BA, Chiappone GA, Layman RR, White RD. Computed Tomography of the coronary arterial circulation of bulldogs under conscious sedation is feasible and defines anomalous anatomy. American College of Veterinary Internal Medicine, 2014. e-Pub 2014.
- Wright CL, Layman RR, Tweedle MF. Optical imaging of positron-emitting radionuclides using Cerenkov luminescence and its potential applications in radioguided surgery. National Academy of Sciences KECK Futures Initiatives, 2013. e-Pub 2013.
- Layman RR, Nagar A, Chiappone G, Bloomston M, White RD. Triple phase liver CT: Three for the price of one. Interdisciplinary Graduate Program Symposium, 2012. e-Pub 2012.
- Kogan I, Hall NC, Phillips V, Murrey DA Layman RR, Knopp MV. Radiation exposure with SPECT/CT imaging: Opportunities for dose reduction and image optimization. RSNA, 2012. e-Pub 2012.
- Hall NC, Zell M, Campbell J, Phillips V, Williams B, Layman RR, Knopp MV. Dynamic acquisition SPECT/CT demonstrates accurate time-activity quantification. RSNA, 2011. e-Pub 2011.
- Campbell J, Hall NC, Zhang J, Williams B, Layman RR, Knopp MV. Quantitatively accurate dynamic SPECT/CT acquisition: Proof of concept in an anthropomorphic phantom. Society of Nuclear Medicine, 2011. e-Pub 2011.
- Layman RR, Hall N, Zhang J, Barker D, Natwa M, Tweedle M, Knopp MV. Overview of current technology in clinical hybrid SPECT/CT. Society of Nuclear Medicine, 2010. e-Pub 2010.
- Layman RR, Hall N, Martin E, Zhang J, Knopp MV. Current SPECT/CT hybrid technologies: A technical and clinical review. RSNA, 2009. e-Pub 2009.
- Carlton M, McKenney R, Zhang J, Layman RR, Hall N, Knopp MV. Managing a micro imaging service for structural functional and molecular imaging. World Molecular Imaging Congress, 2009. e-Pub 2009.
- Zhang J, Hall N, O'Dell CA, Teetor TJ, Sammet S, Jacko R Layman RR, Knopp MV. Quality control management of clinical PET/CT cancer trials. Society of Nuclear Medicine, 2009. e-Pub 2009.
- Zhang J, Hall N, Lacey R, Teetor TJ, Nayal O, Murrey D, Bahnson E, Layman RR, Martin Jr EW, Knopp MV. A thresholding approach to improve metabolic volume assessment in PET/CT: Initial validation of methodology. Society of Nuclear Medicine, 2009. e-Pub 2009.
- Zhang J, Hall J, Sammet S, Layman RR, Knopp MV. The impact of ROI/VOI placement on quantification in 18F-FDG PET/CT. RSNA, 2009. e-Pub 2009.
Selected Presentations & Talks
Local Presentations
- 2019. Effects of CT image acquisition and reconstruction parameters on automatic contouring algorithms. Conference. GSBS Student Research Day. Houston, TX, US.
- 2018. Functional/Metabolic Imaging of Systemic Breast Cancer. Conference. University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2015. Advanced Breast Imaging: X-ray Focused. Conference. The Ohio State University Wexner Medical Center. Columbus, OH, US.
- 2014. Introduction to Medical Physics. Conference. Dublin Scioto High School. Dublin, OH, US.
- 2011. The Physics of Medical Imaging. Conference. Bexley High School. Bexley, OH, US.
Regional Presentations
- 2021. CT: Built for Speed. Conference. Texas Radiological Society. Virtual, US.
- 2019. Physics: CT Applications for Interventional Radiology. Conference. Texas Radiological Society. Austin, TX, US.
- 2019. Physics: Dual-Energy CT. Conference. Texas Radiological Society. Austin, TX, US.
- 2018. Introduction to Dual-Energy CT and Opportunities in Oncologic Imaging. Conference. Southwest Chapter American Association of Physicists in Medicine. Houston, TX, US.
National Presentations
- 2024. Task Group 299 – Quality Control in Multi-Energy Computed Tomography (MECT),. Conference. American Association of Physicist in Medicine. Los Angeles, CA, US.
- 2021. Innovations in dual- and multi-energy CT: Tips and tricks. Invited. Radiological Society of North America. Chicago, IL, US.
- 2020. Contrast in CT. Invited. Radiological Society of North America. Chicago, IL, US.
- 2019. Mathematical model developments for thermoembolization. Conference. Society of Thermal Medicine. St Petersburg, FL, US.
- 2019. Feasibility of CT thermometry of laser ablations in ex-vivo porcine liver. Conference. Society of Thermal Medicine. St Petersburg, FL, US.
- 2018. CT Intensive IV: Regulatory requirements, preparing for inspections. Invited. American Association of Physicists in Medicine. Nashville, TN, US.
- 2018. Valproic acid as a theranostic agent: Computed tomography and mass spectrometry imaging of an imageable ablation agent with anti-tumor properties. Conference. American Society of Mass Spectrometry. San Diego, CA, US.
- 2018. Real time quantitative CT monitoring of thermochemistry by novel application of CsOH. Conference. Society of Thermal Medicine. Tucson, AZ, US.
- 2017. Quantitative MECT material suppression. Invited. American Association of Physicists in Medicine. Denver, CO, US.
- 2015. MR QA/QC for MRgRT. Invited. American Association of Physicists in Medicine. Anaheim, CA, US.
International Presentations
- 2023. CT Simulations for the Safe Clinical Translation of Validated Protocols. Conference. International Society of Computed Tomography. San Diego, US.
- 2021. Guayule Rubber Enhanced Radiation Attenuation Medical Gloves. Conference. International Latex Conference, US.
- 2019. Potential oncologic spectral micro-CT utilization and applications. Invited. MARS Bioimaging. Christchurch, NZ.
- 2017. Multi-energy computed tomography (MECT) imaging of endovascular ablation: Thermoembolization in an ex-vivo porcine kidney model. Conference. Society of Thermal Medicine. Cancun, MX.
- 2017. Theranostic Multiplexed Thermochemical Ablation (MTCA): Tracking dicholoacetate using multi-energy computed tomography. Conference. Society of Thermal Medicine. Cancun, MX.
Formal Peers
- 2018. Implementing dual-energy CT for radiation oncology applications: The diagnostic imaging perspectives. Invited. Nashville, TN, US.
Grant & Contract Support
| Date: | 2024 - 2029 |
| Title: | Transcatheter Chemistry: A Novel Approach In Image-Guided Therapy |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| ID: | 1R01CA290694-01 |
| Date: | 2023 - 2025 |
| Title: | Targeted Reversal of Acidic pH in the Tumor Microenvironment |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| ID: | 1R21CA286397-01 |
| Date: | 2023 - 2030 |
| Title: | Nanoparticle-Enhanced Absorbable Medical Devices for Management of Vascular Diseases |
| Funding Source: | NIH/NHLBI |
| Role: | Co-I |
| ID: | 1R35HL171336-01 |
| Date: | 2023 - 2028 |
| Title: | In Vivo Chemistry As A New Approach To Treat Solid Tumors |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA281013-01A1 |
| Date: | 2023 - 2028 |
| Title: | Reactive Embolization for Selective and Effective Treatment of Solid Tumors |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 1R01CA281724-01 |
| Date: | 2023 - 2028 |
| Title: | In Vivo Chemistry As A New Approach To Treat Solid Tumors |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 1RO1CA281013-01 |
| Date: | 2022 - 2025 |
| Title: | Comprehensive Value-Based CT Imaging to Improve Patient Management in Lung Cancer |
| Funding Source: | Siemens |
| Role: | Multi Principal Investigator |
| ID: | C00242266 |
| Date: | 2022 - 2027 |
| Title: | Image-guided therapy for liver cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA276797-01 |
| Date: | 2022 - 2027 |
| Title: | Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology |
| Funding Source: | NIH/NCI |
| Role: | Co-Mentor |
| ID: | 5T32CA196561-08 |
| Date: | 2022 - 2027 |
| Title: | Combining Heat, Hypoxia, Drugs, Resource Depletion, and Protons: A Disruptive Approach for Liver Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA271439-01 |
| Date: | 2022 - 2025 |
| Title: | Automated image quality assessment for AI applications in cancer treatment |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-PI |
| ID: | RP220366 |
| Date: | 2021 - 2023 |
| Title: | Photon Counting Detector MicroCT |
| Funding Source: | NIH/OD |
| Role: | PI |
| ID: | 1S10OD028621-01A1 |
| Date: | 2021 - 2026 |
| Title: | Precise, durable treatment of liver cancer through convergence of multiple stresses |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA258420-01 |
| Date: | 2021 - 2022 |
| Title: | An automatic system for monitoring quality of diagnostic imaging exams |
| Funding Source: | MDACC |
| Role: | Co-I |
| Date: | 2020 - 2023 |
| Title: | GRIPS: Guayule Radiation-Attenuation Innovative Gloves as a Price-Effective Route to Natural Rubber Security |
| Funding Source: | EnergyEne, Inc. (USDA Pass Thru) |
| Role: | Principal Investigator-MDACC |
| ID: | 2020-33530-32758 |
| Date: | 2020 - 2025 |
| Title: | Monitoring Therapeutic Intervention in Alcoholic Hepatitis By Multi-modal Imaging |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2020 - 2025 |
| Title: | Next Generation Embolization Strategies: Insights into Biology through Chemistry |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA256486-01 |
| Date: | 2020 - 2021 |
| Title: | Multi-modal Imaging for the Prevention of Liver Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP200609 |
| Date: | 2020 - 2025 |
| Title: | Diagnosis and Monitoring of Inflammation and Cell Death in NASH Using PET/CT |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01DK125518-01 |
| Date: | 2020 - 2025 |
| Title: | Numerical characterization of a novel transarterial embolization technique |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01EB029972-01 |
| Date: | 2020 - 2023 |
| Title: | Multi-modal imaging to characterize the spatiotemporal evolution of thermochemical ablation |
| Funding Source: | SIR Foundation |
| Role: | Co-Mentor |
| ID: | FP 10908 RCTS# 58495 |
| Date: | 2020 - 2025 |
| Title: | Multimodal reactive embolization: mechanism, imaging, and systemic effects |
| Funding Source: | NIH/NIBIB |
| Role: | Co-I |
| ID: | 1R01CA243030-01A1 |
| Date: | 2020 - 2021 |
| Title: | Photon Counting Detector MicroCT |
| Funding Source: | NIH/OD |
| Role: | PI |
| ID: | 1S10OD028621-01 |
| Date: | 2020 - 2021 |
| Title: | Development of an automatic image quality assessment platform: a necessary tool for optimized diagnostic imaging |
| Funding Source: | MDACC IRG |
| Role: | Collaborator |
| Date: | 2019 - 2024 |
| Title: | Image-Guided Interventional Biology: Overwhelming Cytoprotective Stress Responses Using a New Ablation Technique |
| Funding Source: | NIH/NIBIB |
| Role: | Co-I |
| ID: | 1R01CA244221-01 |
| Date: | 2019 - 2024 |
| Title: | Multimodal reactive embolization: Mechanism, imaging, and systemic effects |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | PAR-18-252 |
| Date: | 2019 - 2020 |
| Title: | Evaluating and controlling pH in cancer through acidoCEST MRI and in vivo chemistry |
| Funding Source: | CABI Pilot Project Program |
| Role: | Co-I |
| Date: | 2019 - 2024 |
| Title: | Convergent thermal, osmotic, and metabolic stress through image-guided chemistry: a new strategy in cancer therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA239035-01 |
| Date: | 2019 - 2022 |
| Title: | Computational model validation for thermochemical ablation |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | FP00005657 |
| Date: | 2019 - 2021 |
| Title: | Harmonized imaging protocols to maximize success of institutional trials utilizing quantitative image (including radiomics and deep learning) |
| Funding Source: | The Radiation Oncology Strategic Research Initiatives, Division of Radiation Oncology |
| Role: | Co-I |
| Date: | 2018 - 2022 |
| Title: | Single source, imaging and serum biomarkers to predict and identify early cardiac injury from radiation exposure |
| Funding Source: | National Aeronautics and Space Administration (NASA) |
| Role: | Co-I |
| ID: | 80NSSC18K1639 |
| Date: | 2018 - 2023 |
| Title: | Nanoparticle-infused radiopaque absorbable medical device |
| Funding Source: | NIH/NHLBI |
| Role: | Co-I |
| ID: | 5R01HL141831-05 |
| Date: | 2018 - 2022 |
| Title: | DECT silicon image-guided therapy, monitoring and personalized dosimetry of Oncosil |
| Funding Source: | Institutional Research Grant |
| Role: | PI |
| Date: | 2018 - 2019 |
| Title: | Enhanced radiation attenuation medical gloves |
| Funding Source: | USDA |
| Role: | Co-I |
| ID: | SBIR006365 |
| Date: | 2017 - 2019 |
| Title: | Advanced quantitative CT for improved tumor characterization and visualization |
| Funding Source: | Siemens Healthineers |
| Role: | PI |
| ID: | C00225719 |
| Date: | 2013 - 2014 |
| Title: | PET-derived lung dosimetry following 90-yittrium radioembolization |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Co-I |
| Date: | 2013 - 2014 |
| Title: | PET-derived hepatopulmonary shunt fraction following 90-yittrium radioembolization |
| Funding Source: | Radiological Society of North America Research Foundation |
| Role: | Co-I |
| Date: | 2009 - 2012 |
| Title: | The molecular imaging SPECT technology center |
| Funding Source: | Ohio Department of Development |
| Role: | Co-I |
| Date: | 2008 - 2013 |
| Title: | Ohio imaging research and innovation network (OIRAIN) |
| Funding Source: | Ohio Department of Development; Chancellor of the Ohio Board of Regents |
| Role: | Key Personnel |
Patient Reviews
CV information above last modified July 03, 2025