Rick R. Layman, Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
About Dr. Layman
I have worked for many years as a Board Certified Medical Physicist where I have developed translational techniques and optimized imaging methodologies to improve patient diagnosis and characterization of disease. It was during my doctorate work that I critically investigated quantitative molecular imaging methods with the goal to develop non-invasive techniques for accurate imaging based approaches. I specifically studied a targeted theranostic agent 68 Ga/ 177 LuAMBA and developed quantitative molecular imaging (PET/CT and SPECT/CT) methods based on attenuation correction, co-registration, and post-processing. Since joining UT MD Anderson, I have focused on advanced dual-energy CT (DECT) and photon counting detector CT (PCD-CT). This has included the development of clinical protocols and validation for diagnostic interpretation. My research has more specifically focused on quantitative CT to explore unique biomarkers for characterization of oncologic disease and response to therapy.
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Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Member, Division of Medical Physics, MD Anderson Cancer Center - UT Health Graduate School of Biomedical Sciences (UT-GSBS), Houston, TX
Research Interests
Quantitative imaging focused on multi-energy CT with PCD-CT and DECT
Education & Training
Degree-Granting Education
| 2013 | Ohio State University, Columbus, OH, USA, PHD, Biophysics |
| 2000 | John Carroll University, University Heights, OH, USA, MS, Chemistry |
| 1997 | Case Western Reserve University, Cleveland, OH, USA, BA, Chemistry and Environmental Geology |
Board Certifications
| 2004 | American Board of Radiology, Diagnostic Medical Physics |
Experience & Service
Academic Appointments
Assistant Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2019
Assistant Professor, Department of Department of Radiology, Division of College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 2013 - 2016
Instructor, Department of Department of Radiology, Division of College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 2008 - 2013
Administrative Appointments/Responsibilities
Diagnostic Medical Physicist and Radiation Safety Officer, William Beaumont Hospital, Troy, MI, 2004 - 2008
Staff Medical Physicist, The Cleveland Clinic Foundation, Cleveland, OH, 1999 - 2004
Graduate Assistant, Department of Chemistry, John Carroll University, University Heights, OH, 1997 - 1999
Honors & Awards
| 2022 | Fellow, American Association of Physicist in Medicine |
Selected Publications
Peer-Reviewed Articles
- Thompson EA, Fowlkes NW, Jacobsen MC, Layman RR, Cressman ENK. Quantitative Dual-Energy Computed Tomography Image Guidance for Thermochemical Ablation: in vivo Results in the Rabbit VX2 Model. J Vasc Interv Radiol. e-Pub 2022. PMID: 36539151.
- Damasco JA, Huang SY, Perez JVD, Manongdo JAT, Dixon KA, Williams ML, Jacobsen MC, Barbosa R, Canlas GM, Chintalapani G, Melancon AD, Layman RR, Fowlkes NW, Whitley EM, Melancon MP. Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs. ACS Biomater Sci Eng 8(4):1676-1685, 2022. e-Pub 2022. PMID: 35343679.
- Ramirez Cadavid DA, Layman RR, Nishino T, Slutzky JL, Li Z, Cornish K. Guayule Natural Rubber Latex and Bi2O3 Films for X-ray Attenuating Medical Gloves. Materials (Basel) 15(3), 2022. e-Pub 2022. PMID: 35161128.
- Layman RR, Hardy AJ, Kim HJ, Chou EN, Bostani M, Cagnon C, Cody D, McNitt-Gray M. A Comparison of Breast and Lung Doses from Chest CT Scans Using Organ-Based Tube Current Modulation (OBTCM) vs. Automatic Tube Current Modulation (ATCM). J Appl Clin Med Phys 22(5):97-109, 2021. e-Pub 2021. PMID: 33939253.
- Huang K, Rhee DJ, Ger R, Layman R, Yang J, Cardenas CE, Court LE. Impact of slice thickness, pixel size, and CT dose on the performance of automatic contouring algorithms. J Appl Clin Med Phys. e-Pub 2021. PMID: 33779037.
- Ahmad M, Jacobsen MC, Thomas MA, Chen HS, Layman RR, Jones AK. A Benchmark for automatic noise measurement in clinical computed tomography. Med Phys. e-Pub 2020. PMID: 33283284.
- Fuentes D, Thompson E, Jacobsen M, Crouch AC, Layman RR, Riviere B, Cressman E. Imaging-based characterization of convective tissue properties. Int J Hyperthermia 37(3):155-163, 2020. PMID: 33426993.
- Perez JVD, Jacobsen MC, Damasco JA, Melancon A, Huang SY, Layman RR, Melancon MP. Optimization of the differentiation and quantification of high-Z nanoparticles incorporated in medical devices for CT-guided interventions. Med Phys. e-Pub 2020. PMID: 33216978.
- Huang SY, Damasco JA, Tian L, Lu L, Perez JVD, Dixon KA, Williams ML, Jacobsen MC, Dria SJ, Eggers MD, Melancon AD, Layman RR, Whitley EM, Melancon MP. In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model. Biomater Sci 8(14):3966-3978, 2020. e-Pub 2020. PMID: 32558854.
- Javadi S, Elsherif S, Bhosale P, Jensen CT, Layman RR, Jacobsen MC, Le O, Jia S, Parikh RJ, Tamm EP. Quantitative attenuation accuracy of virtual non-enhanced imaging compared to that of true non-enhanced imaging on dual-source dual-energy CT. Abdom Radiol (NY) 45(4):1100-1109, 2020. e-Pub 2020. PMID: 32052130.
- McCollough CH, Boedeker K, Cody D, Duan X, Flohr T, Halliburton S, Hsieh J, Layman R, Pelc NJ. Principles and Applications of Multi-energy CT Report of AAPM Task Group 291. Med Phys. e-Pub 2020. PMID: 32215937.
- Fuentes D, Fahrenholtz SJ, Guo C, MacLellan CJ, Layman RR, Rivière B, Stafford RJ, Cressman E. Mathematical modeling of mass and energy transport for thermoembolization. Int J Hyperthermia 37(1):356-365, 2020. PMID: 32308071.
- Branco LRF, Ger RB, Mackin DS, Zhou S, Court LE, Layman RR. Technical Note: Proof of concept for radiomics-based quality assurance for computed tomography. J Appl Clin Med Phys 20(11):199-205, 2019. e-Pub 2019. PMID: 31609076.
- Jacobsen MC, Cressman ENK, Tamm EP, Baluya DL, Duan X, Cody DD, Schellingerhout D, Layman RR. Dual-Energy CT: Lower limits of iodine detection and quantification. Radiology 292(2):414-419, 2019. e-Pub 2019. PMID: 31237496.
- Mujtaba B, Hanafy AK, Largo RD, Taher A, Madewell JE, Costelloe C, Layman RR, Morani AC. The lumbar artery perforator flap: clinical review and guidance on image reporting. Clin Radiol. e-Pub 2019. PMID: 31300211.
- Mujtaba B, Gu L, Largo RD, Amini B, Layman RR, Madewell JE, Costelloe CM. VIDEO: Preoperative CT Angiography for Scapula Osteocutaneous Free Flap Reconstructions. AJR Am J Roentgenol:W1-W2. e-Pub 2019. PMID: 31166756.
- MacLellan CJ, Layman RR, Geiser W, Gress DA, Kyle Jones A. Evaluation of an Automated Grid Artifact Detection System for Quality Control in Digital Mammography. Med Phys. e-Pub 2019. PMID: 31116445.
- Makary MS, Lionberg A, Khayat M, Lustberg MB, AlTaani J, Pan XJ, Layman RR, Raman SV, Layman RM, Dowell JD. Advanced stage breast cancer is associated with catheter-tip thrombus formation following implantable central venous port placement. Phlebology 34(2):268355518774442, 2019. e-Pub 2018. PMID: 29771187.
- Fahrenholtz SJ, Guo C, MacLellan CJ, Yung JP, Hwang KP, Layman RR, Stafford RJ, Cressman E. Temperature mapping of exothermic in situ chemistry: imaging of thermoembolization via MR. Int J Hyperthermia 36(1):730-738, 2019. PMID: 31362538.
- Ger RB, Meier JG, Pahlka RB, Gay S, Mumme R, Fuller CD, Li H, Howell RM, Layman RR, Stafford RJ, Zhou S, Mawlawi O, Court LE. Effects of alterations in positron emission tomography imaging parameters on radiomics features. PLoS One 14(9):e0221877, 2019. e-Pub 2019. PMID: 31487307.
- Ger RB, Zhou S, Elgohari B, Elhalawani H, Mackin DM, Meier JG, Nguyen CM, Anderson BM, Gay C, Ning J, Fuller CD, Li H, Howell RM, Layman RR, Mawlawi O, Stafford RJ, Aerts H, Court LE. Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients. PLoS One 14(9):e0222509, 2019. e-Pub 2019. PMID: 31536526.
- Ger RB, Craft DF, Mackin DS, Zhou S, Layman RR, Jones AK, Elhalawani H, Fuller CD, Howell RM, Li H, Stafford RJ, Court LE. Practical guidelines for handling head and neck computed tomography artifacts for quantitative image analysis. Comput Med Imaging Graph 69:134-139, 2018. e-Pub 2018. PMID: 30268005.
- Ger RB, Zhou S, Chi PM, Lee HJ, Layman RR, Jones AK, Goff DL, Fuller CD, Howell RM, Li H, Stafford RJ, Court LE, Mackin DS. Comprehensive investigation on controlling for CT imaging variabilities in radiomics studies. Sci Rep 8(1):13047, 2018. e-Pub 2018. PMID: 30158540.
- Hostnik ET, Scansen BA, Habing AM, Chiappone GA, Layman RR, White RD. Comparison of cardiac measurements by multi-detector computed tomography angiography and transthoracic echocardiography in English bulldogs. J Vet Cardiol 19(6):480-491, 2017. e-Pub 2017. PMID: 29174197.
- Tamm EP, Le O, Liu X, Layman RR, Cody DD, Bhosale PR. How to incorporate dual energy imaging into a high volume abdominal imaging practice. Abdom Radiol (NY) 42(3):688-701, 2017. e-Pub 2017. PMID: 28070657.
- Goceri E, Shah ZK, Layman RR, Jiang X, Gurcan MN. Quantification of liver fat: A comprehensive review. Comput Biol Med 71:174-89, 2016. e-Pub 2016. PMID: 26945465.
- Cody DD, Fisher TS, Gress DA, Layman RR, McNitt-Gray MF, Pizzutiello RJ, Fairobent LA. AAPM medical physics practice guideline 1.a: CT protocol management and review practice guideline. J Appl Clin Med Phys 14(5):3-12, 2013. e-Pub 2013. PMID: 24036879.
- Matisoff G, Ketterer ME, Wilson CG, Layman R, Whiting PJ. Transport of rare earth element-tagged soil particles in response to thunderstorm runoff. Environ Sci Technol 35(16):3356-62, 2001. PMID: 11529577.
- Ketterer ME, Wetzel WC, Layman RR, Matisoff G, Bonniwell EC. Isotopic studies of sources of uranium in sediments of the Ashtabula River, Ohio. Environ Sci Technol 34:966-972, 2000.
- Ketterer ME, Jordan JA, Szechenyi SC, Hudson DD, Layman RR. Envirogeochemical exploration for NORM Wastes: Quadrupole ICPMS measurements of thorium and uranium isotopes. J Anal Atom Spectrom 15:1569-1573, 2000.
Invited Articles
- Jacobsen MC, Thrower SL, Ger RB, Leng S, Court LE, Brock KK, Tamm EP, Cressman ENK, Cody DD, Layman RR. Multi-energy computed tomography and material quantification: Current barriers and opportunities for advancement. Med Phys. e-Pub 2020. PMID: 32453879.
Book Chapters
- Bakalyar D, Holsbeeck M, Layman R, Madrazo B. Physical principles of ultrasound artifacts in two dimensions. In: Variants and Pitfalls in Body Imaging: Thoracic, Abdominal and Women's Imaging 2nd edition. Lippincott Williams & Wilkins: Philadelphia, 2009.
Grant & Contract Support
| Title: | Enhanced radiation attenuation medical gloves |
| Funding Source: | USDA |
| Role: | Co-Investigator |
| Title: | DECT silicon image-guided therapy, monitoring and personalized dosimetry of Oncosil |
| Funding Source: | Institutional Research Grant |
| Role: | Principal Investigator |
| Title: | Nanoparticle-infused radiopaque absorbable medical device |
| Funding Source: | NIH/NHLBI |
| Role: | Co-Investigator |
| Title: | Photon Counting Detector MicroCT |
| Funding Source: | NIH/OD |
| Role: | Principal Investigator |
| Title: | Automated image quality assessment for AI applications in cancer treatment |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Principal Investigator |
| Title: | Comprehensive Value-Based CT Imaging to Improve Patient Management in Lung Cancer” |
| Funding Source: | Siemens |
| Role: | Principal Investigator |