Ronald A. DePinho, M.D.
Department of Cancer Biology, Division of Basic Sciences
Present Title & Affiliation
Primary Appointment
Past President, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Cancer Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | Harvard University, Cambridge, MA, USA, MS (Hon.), Honorary |
| 1981 | Albert Einstein College of Medicine, Bronx, NY, USA, MD, Microbiology & Immunology |
| 1977 | Fordham College, New York, NY, USA, BS, Biological Sciences |
Postgraduate Training
| 1984-1985 | Postdoctoral Fellowship, Albert Einstein College of Medicine, Department of Cell Biology, Bronx, NY |
| 1984-1988 | Postdoctoral Fellowship, Albert Einstein College of Medicine, Department of Biochemistry & Biophysics, Bronx, NY |
Board Certifications
| 1984 | Board Certified in Internal Medicine |
Experience & Service
Academic Appointments
Professor of Medicine (Genetics), Harvard Medical School, Boston, MA, 1998 - 2011
Professor, Department of Departments of Microbiology & Immunology, and Medicine, Albert Einstein College of Medicine, Bronx, NY, 1997 - 1998
Associate Professor, Department of Departments of Microbiology & Immunology, and Medicine, Albert Einstein College of Medicine, Bronx, NY, 1993 - 1997
Assistant Professor, Department of Departments of Microbiology & Immunology, and Medicine, Albert Einstein College of Medicine, Bronx, NY, 1988 - 1993
Administrative Appointments/Responsibilities
Director, Belfer Institute for Applied Cancer Science (f/k/a Center for Applied Cancer Science), Dana-Farber Cancer Institute, Boston, MA, 2004 - 2011
Scientific Director, Mouse Specialized Services, Dana-Farber/Harvard Cancer Center, Boston, MA, 1999 - 2004
Scientific Director, Transgenic & Gene Targeting Facility, Dana-Farber Cancer Institute, Boston, MA, 1998 - 2011
Scientific Director, Transgenic & Gene Targeting Facility, Albert Einstein College of Medicine, Bronx, NY, 1988 - 1998
Other Appointments/Responsibilities
Co-Founder and Director, Scientific Advisory Board, Eden Therapeutics, Inc, Houston, TX, 2008 - 2012
Co-Founder and Director, Scientific Advisory Board, Metamark Genetics, Inc, Cambridge, MA, 2007 - 2012
Co-Founder and Director, Scientific Advisory Board, AVEO Pharmaceuticals, Inc. (f/k/a GenPath), Cambridge, MA, 2001 - 2012
Organizer & Director, NCI Mouse Developmental Genetics Course, Albert Einstein College of Medicine, Bronx, NY, 1991 - 1998
Attending Physician, Jacobi Hospital, Albert Einstein College of Medicine, Bronx, NY, 1988 - 1997
Consultantships
Scientific Advisory Board, Sidney Kimmel Foundation, Philadelphia, PA, 8888 - Present
Honors & Awards
| 2010 | Member, American Academy of Arts and Sciences |
| 2009 | Albert Szent-Györgyi Prize for Progress in Cancer Research |
| 2007 | Harvey Society Lecture |
| 2007 | Biomedicum Helsinki Medal and Lecture |
| 2004 | Albert Einstein College of Medicine Distinguished Alumnus Award |
| 2004 | American Cancer Society Edith A. Pistorino Research Professorship |
| 2004 | Member, Institute of Medicine (now Health and Medicine Division) of the National Academies |
| 2003 | AACR-G.H.A. Clowes Memorial Award |
| 2003 | The Ellison Medical Foundation Senior Scholar Award |
| 2002 | American Society for Clinical Investigation Award (now Korsmeyer Award) |
| 2000 | Kirsch Senior Investigator Award |
| 2000 | Clair W. & Richard P. Morse Research Award, Dana-Farber Cancer Institute, Boston |
| 1998 | American Cancer Society Research Professorship |
| 1995 | Irma T. Hirschl Career Scientist Award |
| 1993 | Melini Award for Excellence in Biomedical Research |
| 1992 | Feinberg Senior Faculty Scholar in Cancer Research |
| 1992 | American Heart Association Established Investigator Award |
| 1989 | Cancer Research Institute Investigator Award |
| 1989 | March of Dimes Basil O'Connor Scholar Award |
| 1988 | James S. McDonnell Foundation Scholar Award |
| 1981 | M.D. with distinction in Microbiology & Immunology, Albert Einstein College of Medicine |
| 1981 | Eli H. Rubin Award in Medicine |
| 1977 | Salutatorian and Summa Cum Laude, Fordham University |
| 1977 | Steinbugler Award for Biology, Fordham University |
| 1976 | Phi Beta Kappa, Fordham University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470(7334):359-65, 2011. e-Pub 2011. PMID: 21307849.
- Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 470(7333):269-73, 2011. e-Pub 2011. PMID: 21289624.
- Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469(7328):102-6, 2011. e-Pub 2010. PMID: 21113150.
- Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-4, 2010. PMID: 21124456.
- Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-84, 2010. PMID: 21075312.
- Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509, 2010. PMID: 20478531.
- Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5(5):540-53, 2009. PMID: 19896444.
- Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455(7216):1129-33, 2008. PMID: 18948956.
- Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318(5848):287-90, 2007. e-Pub 2007. PMID: 17872411.
- Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447(7147):966-71, 2007. e-Pub 2007. PMID: 17515920.
- Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128(2):309-23, 2007. PMID: 17254969.
- Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421(6923):643-8, 2003. e-Pub 2003. PMID: 12540856.
- Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic Ras in tumour maintenance. Nature 400(6743):468-72, 1999. PMID: 10440378.
- Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97(4):527-38, 1999. PMID: 10338216.
- Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 392(6676):569-74, 1998. PMID: 9560153.
Grant & Contract Support
| Title: | Genetics and Biology of Malignant Glioma |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Genetics and Biology of Pancreatic Ductal Adenocarcinoma |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Telomerase in Development, Senescence and Neoplasia |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | The Role of PTEN and the PI3K Pathway in Prostate Cancer-Mouse Genome Manipulation Core |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Uses of GEM models for Translational Cancer Research |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Systematic functional interrogation of the GBM genome for curative combination therapy |
| Funding Source: | Ben and Catherine Ivy Foundation |
| Role: | Co-Principal Investigator |
| Title: | Myeloma SPORE: Lung, Leukemia and Myeloma Cancers Project 2 |
| Funding Source: | NIH/NCI |
| Role: | Investigator |
| Title: | NCI Cancer Center Support Grant |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |