Roy F Chemaly, M.D., M.P.H., F.A.C.P., F.I.D.S.A.
Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Professor, The University of Texas School of Public Health, Houston, TX
Professor, Department of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Adjunct Professor, Baylor College of Medicine, Houston, TX
Education & Training
Degree-Granting Education
| 1992 | Saint Joseph University, Faculty of Medicine, Beirut, LBN, MD, Doctor of Medicine |
Postgraduate Training
| 2012-2013 | Faculty Leadership Academy, Leadership Development Program, MD Anderson Cancer Center, Houston, TX |
| 2004-2004 | Patient Safety Officer Training, Institute for Health Care Delivery Research, Salt Lake City, UT |
| 2004-2004 | Advanced Training Program in Health Care Delivery Research, IHC Institute for Health Care Delivery Research, Salt Lake City, UT |
| 2000-2002 | Masters in Public Health, Northeastern Ohio Universities, Rootstown, OH |
| 2000-2002 | Fellowship, Clinical Microbiology, The Cleveland Clinic Foundation, Cleveland, OH |
| 1998-2000 | Fellowship, Infectious Diseases, The Cleveland Clinic Foundation, Cleveland, OH |
| 1997-1998 | Chief Medical Resident, Staten Island University Hospital, Staten Island, NY |
Board Certifications
| 2019 | American Board of Medical Quality, Recertification |
| 2014 | American Board of Medical Quality |
| 2010 | American Board of Internal Medicine Infectious Diseases Subspecialty |
| 2009 | American Board of Internal Medicine, Recertification |
| 2001 | American Board of Pathology Medical Microbiology Subspecialty |
| 2000 | American Board of Internal Medicine Infectious Diseases Subspecialty |
| 1997 | American Board of Internal Medicine |
Experience & Service
Academic Appointments
Associate Professor, Department of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2013
Administrative Appointments/Responsibilities
Vice Chair, Division of Internal Medicine Safety and Quality Council, Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2018
Quality Officer, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - Present
Director, Infection Control Program, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - Present
Other Appointments/Responsibilities
Member, The Practice Guidelines for Respiratory Viruses of the European Conference on Infections in Leukemia (ECIL-8), Houston, TX, 2019 - Present
Co-Chair, Infection & Immune Reconstitution Working Committee of the CIBMTR, Houston, TX, 2019 - Present
Member, The Council for the International Immunocompromised Host Society, Houston, TX, 2018 - Present
Co-Chair, CMV Resistance/Refractory Working Group of the CMV Drug Development Forum, Houston, TX, 2017 - 2018
Institutional Committee Activities
Member, The Quality Assurance and Performance Improvement (QAPI) Council, 2019 - Present
Chair, Division of Internal Medicine Quality and Safety Council, 2019 - Present
Chair, Conflict of Interest, 2016 - 2018
Vice Chair, Conflict of Interest, 2015 - 2016
Chair, Infection Control Committee, 2008 - Present
Vice Chair, Institutional Review Committee (IRB #5), 2007 - 2010
Honors & Awards
| 2018 | American Cancer Society Mentorship Award (Mentor to Dr Lynn El Haddad),, The University of Texas MD Anderson Cancer Center |
| 2017 | Excellence in Research Winner, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center |
| 2016 | James S. and Suzanne Cyrus Scholar Award (Mentor to Dr. Dimpy Shah), The University of Texas MD Anderson Cancer Center |
| 2016 | Finalist, The Julie and Ben Rogers Award for Excellence in the area of Prevention, The University of Texas MD Anderson Cancer Center |
| 2016 | Distinguished Paper Award, University of Texas MD Anderson Cancer Center-Division of Internal Medicine |
| 2015 | The Lupe C. Garcia Research Endowed Fellowship Award Winner (mentor to Dr. Dimpy Shah), The University of Texas MD Anderson Cancer Center |
| 2015 | Finalist for the James S. and Suzanne Cyrus Scholar Award (mentor to Dr. Dimpy Shah), The University of Texas MD Anderson Cancer Center |
| 2015 | Team Member, Containing Inappropriate Gram-Positive Antibiotic Use (Cignus), University of Texas MD Anderson Cancer Center |
| 2014 | James S. and Suzanne Cyrus Scholar Award (Mentor to Dr. Ella Ariza-Heredia), The University of Texas MD Anderson Cancer Center |
| 2014 | Administrative Leader of the Year, University of Texas MD Anderson Cancer Center-Division of Internal Medicine |
| 2014 | Distinguished Paper Award, University of Texas MD Anderson Cancer Center-Division of Internal Medicine |
| 2013 | Certificate of Completion of Faculty Leadership Academy |
| 2012 | Recognition for Act++ Project, MDACC Office of Performance Improvement |
| 2011 | Top Doctor, Castle Connolly Medical Ltd |
| 2011 | Best Doctor, US News Health |
| 2010 | 2nd Place Winner for Outstanding Patient Safety and Quality Improvement Project entitled "VAP can be eradicated", Clinical Safety and Effectiveness Conference, November 4-5, 2010, Austin, Texas |
| 2009 | Certificate of completion, 2009 Junior Heart of Leadership Program, MD Anderson Cancer Center |
| 2008 | Patient Safety Champion Award (related to the investigation of the Serratia marescens Outbreak), The University of Texas M. D. Anderson Cancer Center, Houston, Texas |
| 2008 | Awarded Best Clinical Poster Presentation (Mentor to Dr. Karen Vigil) Second Infections in Cancer Symposium, The University of Texas M. D. Anderson Cancer Center |
| 2008 | Medical Leadership Award for the Infections in Cancer Symposium, The University of Texas M. D. Anderson Cancer Center, Houston, Texas |
| 2007 | Fellow, The American College of Physicians |
| 2007 | Second Prize Winner (Mentor for Dr. Harrys Torres) for outstanding poster at the Annual Meeting, Texas Infectious Diseases Society |
| 2007 | Fellow, Infectious Disease Society of America |
| 2007 | America's Top Physician, Consumers Research Council of America |
| 2007 | Certificate of Appreciation (for providing excellent protocol review), The University of Texas M. D. Anderson Cancer Center |
| 2005 | Leadership Award, Alumni Association of North America, American University of Beirut |
| 2005 | First Prize Winner for our work on Influenza Infections in Leukemia Patients and the Impact of Neuraminidase Inhibitors (Mentor to Harrys Torres, MD), The First Biannual National Meeting for Infection in Cancer Symposium, Houston, Texas |
| 2000 | Finalist Award, Infectious Diseases Society of Ohio |
Selected Publications
Peer-Reviewed Articles
- Marty F, Chemaly RF, Mullane K, Lee DG, Hirsch HH, Small CB, Bergeron A, Sholam S, Ljungman P, Waghmare A. . A phase 2b, randomized, double-blind, placebo-controlled multicenter study evaluating antiviral effects, pharmacokinetics, safety, and tolerability of presatovir in hematopoietic cell transplant recipients with respiratory syncytial virus (RSV) infection of the lower respiratory tract, 2019. e-Pub 2019.
- Kmeid J, Kulkarni PA, Batista MV, El Chaer F, Prayag A, Ariza-Heredia EJ, Mulanovich VE, Chemaly RF. Active Mycobacterium tuberculosis infection at a comprehensive cancer center, 2006-2014. BMC Infect Dis 19(1):934, 2019. e-Pub 2019. PMID: 31694567.
- Kontoyiannis DP, Shah EC, Wurster S, Aitken SL, Graviss L, Raad II, Chemaly RF. Culture-Documented Invasive Mold Infections at MD Anderson Cancer Center in Houston, Texas, Pre- and Post-Hurricane Harvey. Open Forum Infect Dis 6(4):ofz138, 2019. e-Pub 2019. PMID: 31024975.
- El Haddad L, Ghantoji SS, Stibich M, Fleming JB, Segal C, Ware KM, Chemaly RF. Evaluation of a pulsed xenon ultraviolet disinfection system to decrease bacterial contamination in operating rooms. BMC Infect Dis 17(1):672, 2017. e-Pub 2017. PMID: 29017457.
- El-Haddad D, El Chaer F, Vanichanan J, Shah DP, Ariza-Heredia EJ, Mulanovich VE, Gulbis AM, Shpall EJ, Chemaly RF. Brincidofovir (CMX-001) for refractory and resistant CMV and HSV infections in immunocompromised cancer patients: A single-center experience. Antiviral Res 134:58-62, 2016. e-Pub 2016. PMID: 27582067.
- Nesher L, Shah DP, Ariza-Heredia EJ, Azzi JM, Siddiqui HK, Ghantoji SS, Marsh LY, Michailidis L, Makedonas G, Rezvani K, Shpall EJ, Chemaly RF. Utility of the Enzyme-Linked Immunospot Interferon-γ-Release Assay to Predict the Risk of Cytomegalovirus Infection in Hematopoietic Cell Transplant Recipients. J Infect Dis 213(11):1701-7, 2016. e-Pub 2016. PMID: 26908740.
- Kmeid J, Vanichanan J, Shah DP, El Chaer F, Azzi J, Ariza-Heredia EJ, Hosing C, Mulanovich V, Chemaly RF. Outcomes of Influenza Infections in Hematopoietic Cell Transplant Recipients: Application of an Immunodeficiency Scoring Index. Biol Blood Marrow Transplant 22(3):542-8, 2016. e-Pub 2015. PMID: 26638804.
- Shah DP, Shah PK, Azzi JM, Chemaly RF. Parainfluenza virus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: A systematic review. Cancer Lett 370(2):358-64, 2016. e-Pub 2015. PMID: 26582658.
- Chemaly RF, Ghantoji SS, Huber T, Raad II, Jinadatha C, Stibich M. Innovative Analysis of the Sequenced Patterns of Vancomycin-Resistant Enterococci Strains to Determine Clonal Transmission in a Hospital Setting. Infect Control Hosp Epidemiol 36(12):1-3, 2015. e-Pub 2015. PMID: 26329908.
- Avadhanula V, Chemaly RF, Shah DP, Ghantoji SS, Azzi JM, Aideyan LO, Mei M, Piedra PA. Infection with Novel Respiratory Syncytial Virus Genotype Ontario (ON1) in Adult Hematopoietic Cell Transplant Recipients, Texas, 2011-2013. J Infect Dis 211(4):582-9, 2015. e-Pub 2014. PMID: 25156562.
- Nesher L, Rolston KV, Shah DP, Tarrand JT, Mulanovich V, Ariza-Heredia EJ, Chemaly RF. Fecal colonization and infection with Pseudomonas aeruginosa in recipients of allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 17(1):1-6, 2015. e-Pub 2014. PMID: 25546740.
- Ghantoji SS, Stibich M, Stachowiak J, Cantu S, Adachi JA, Raad II, Chemaly RF. Non-inferiority of pulsed xenon UV light versus bleach for reducing environmental Clostridium difficile contamination on high-touch surfaces in Clostridium difficile infection isolation rooms. J Med Microbiol 64(Pt 2):191-4, 2015. PMID: 25627208.
- Chemaly RF, Dantes R, Shah DP, Shah PK, Pascoe N, Ariza-Heredia E, Perego C, Nguyen DB, Nguyen K, Modarai F, Moulton-Meissner H, Noble-Wang J, Tarrand JJ, LiPuma JJ, Guh AY, MacCannell T, Raad I, Mulanovich V. Cluster and Sporadic Cases of Herbaspirillum spp. Infections in Patients with Cancer. Clin Infect Dis 60(1):48-54, 2015. e-Pub 2014. PMID: 25216687.
- Boeckh M, Nichols WG, Chemaly RF, Papanicolaou GA, Wingard JR, Xie H, Syrjala KL, Flowers ME, Stevens-Ayers T, Jerome KR, Leisenring W. Valganciclovir for the prevention of complications of late cytomegalovirus infection after allogeneic hematopoietic cell transplantation: a randomized trial. Ann Intern Med 162(1):1-10, 2015. PMID: 25560711.
- Ariza-Heredia EJ, Gulbis AM, Stolar KR, Kebriaei P, Shah DP, McConn KK, Champlin RE, Chemaly RF. Vaccination guidelines after hematopoietic stem cell transplantation: practitioners' knowledge, attitudes, and gap between guidelines and clinical practice. Transpl Infect Dis 16(6):878-86, 2014. e-Pub 2014. PMID: 25405922.
- Chemaly RF, Ghantoji SS, Shah DP, Shah JN, El Taoum KK, Champlin RE, Nunez CA, Mulanovich V, Ariza-Heredia E. Respiratory Syncytial Virus Infections in Children with Cancer. J Pediatr Hematol Oncol 36(6):e376-81, 2014. PMID: 24327130.
- Chemaly RF, Ullmann AJ, Stoelben S, Richard MP, Bornhäuser M, Groth C, Einsele H, Silverman M, Mullane KM, Brown J, Nowak H, Kölling K, Stobernack HP, Lischka P, Zimmermann H, Rübsamen-Schaeff H, Champlin RE, Ehninger G, AIC246 Study Team. Letermovir for cytomegalovirus prophylaxis in hematopoietic-cell transplantation. N Engl J Med 370(19):1781-9, 2014. PMID: 24806159.
- Yilmaz M, Chemaly RF, Han XY, Thall PF, Fox PS, Tarrand JJ, De Lima MJ, Hosing CM, Popat UR, Shpall E, Champlin RE, Qazilbash MH. Adenoviral infections in adult allogeneic hematopoietic SCT recipients: a single center experience. Bone Marrow Transplant 48(9):1218-23, 2013. e-Pub 2013. PMID: 23503529.
- Shah DP, Ghantoji SS, Shah JN, El Taoum KK, Jiang Y, Popat U, Hosing C, Rondon G, Tarrand JJ, Champlin RE, Chemaly RF. Impact of aerosolized ribavirin on mortality in 280 allogeneic haematopoietic stem cell transplant recipients with respiratory syncytial virus infections. J Antimicrob Chemother 68(8):1872-80, 2013. e-Pub 2013. PMID: 23572228.
- Chemaly RF, Torres HA, Munsell MF, Shah DP, Rathod DB, Bodey GP, Hosing C, Saifan C, Raad II, Champlin RE. An adaptive randomized trial of an intermittent dosing schedule of aerosolized ribavirin in patients with cancer and respiratory syncytial virus infection. J Infect Dis 206(9):1367-71, 2012. e-Pub 2012. PMID: 22927454.
- Chemaly RF, Vigil KJ, Saad M, Vilar-Compte D, Cornejo-Juarez P, Perez-Jimenez C, Mubarak S, Salhab M, Jiang Y, Granwehr B, Adachi JA, Raad II. A multicenter study of pandemic influenza a (H1N1) infection in patients with solid tumors in 3 countries: Early therapy improves outcomes. Cancer 118(18):4627-33, 2012. e-Pub 2012. PMID: 22359314.
- Shah DP, El Taoum KK, Shah JN, Vigil KJ, Adachi JA, Granwehr BP, Tarrand JJ, Raad II, Chemaly RF. Characteristics and Outcomes of Pandemic 2009/H1N1 versus Seasonal Influenza in Children with Cancer. Pediatr Infect Dis J 31(4):373-8, 2012. e-Pub 2012. PMID: 22228234.
- Chemaly RF, Hanmod SS, Rathod DB, Ghantoji SS, Jiang Y, Doshi A, Vigil K, Adachi JA, Khoury AM, Tarrand J, Hosing C, Champlin R. The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation. Blood 119(12):2738-45; quiz 2969, 2012. e-Pub 2012. PMID: 22246027.
- Anaya DA, Cormier JN, Xing Y, Koller P, Gaido L, Hadfield D, Chemaly RF, Feig BW. Development and Validation of a Novel Stratification Tool for Identifying Cancer Patients at Increased Risk of Surgical Site Infection. Ann Surg 255(1):134-9, 2012. e-Pub 2011. PMID: 22143206.
- Mahajan SN, Shah JN, Hachem R, Tverdek F, Adachi JA, Mulanovich V, Rolston KV, Raad II, Chemaly RF. Characteristics and Outcomes of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Patients with Cancer Treated with Vancomycin: 9-Year Experience at a Comprehensive Cancer Center. Oncologist 17(10):1329-36, 2012. e-Pub 2012. PMID: 22707509.
- Chemaly RF, Rathod DB, Sikka MK, Hayden MK, Hutchins M, Horn T, Tarrand J, Adachi J, Nguyen K, Trenholme G, Raad I. Serratia marcescens bacteremia because of contaminated prefilled heparin and saline syringes: A multi-state report. Am J Infect Control 39(6):521-4, 2011. e-Pub 2011. PMID: 21492963.
- Marty FM, Ljungman P, Papanicolaou GA, Winston DJ, Chemaly RF, Strasfeld L, Young JA, Rodriguez T, Maertens J, Schmitt M, Einsele H, Ferrant A, Lipton JH, Villano SA, Chen H, Boeckh M, Maribavir 1263-300 Clinical Study Group. Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial. Lancet Infect Dis 11(4):284-92, 2011. e-Pub 2011. PMID: 21414843.
- Stibich M, Stachowiak J, Tanner B, Berkheiser M, Moore L, Raad I, Chemaly RF. Evaluation of a pulsed-xenon ultraviolet room disinfection device for impact on hospital operations and microbial reduction. Infect Control Hosp Epidemiol 32(3):286-8, 2011. PMID: 21460515.
- Safdar A, Rodriguez GH, Mihu CN, Mora-Ramos L, Mulanovich V, Chemaly RF, Champlin RE, Khouri I. Infections in Nonmyeloablative Hematopoietic Stem Cell Transplantation Patients with Lymphoid Malignancies: Spectrum of Infections, Predictors of Outcome, and Proposed Guidelines for Fungal Infection Prevention. Bone Marrow Transplant 45(2):339-47, 2010. e-Pub 2009. PMID: 19561648.
- Chemaly RF, Hachem RY, Husni RN, Bahna B, Abou Rjaili G, Waked A, Graviss L, Nebiyou Bekele B, Shah JN, Raad II. Characteristics and Outcomes of Methicillin-Resistant Staphylococcus aureus Surgical-Site Infections in Patients with Cancer: a Case-Control Study. Ann Surg Oncol 17(6):1499-506, 2010. e-Pub 2010. PMID: 20127184.
- Chaftari AM, Hachem R, Mulanovich V, Chemaly RF, Adachi J, Jacobson K, Jiang Y, Raad I. Efficacy and safety of daptomycin in the treatment of Gram-positive catheter-related bloodstream infections in cancer patients. Int J Antimicrob Agents 36(2):182-6, 2010. e-Pub 2010. PMID: 20452752.
- Kassis C, Champlin RE, Hachem RY, Hosing C, Tarrand JJ, Perego CA, Neumann JL, Raad II, Chemaly RF. Detection and Control of a Nosocomial Respiratory Syncytial Virus Outbreak in a Stem Cell Transplantation Unit: The Role of Palivizumab. Biol Blood Marrow Transplant 16(9):1265-71, 2010. e-Pub 2010. PMID: 20304082.
- Adachi JA, Perego C, Graviss L, Dvorak T, Hachem R, Chemaly RF, Raad II. The role of interventional molecular epidemiology in controlling clonal clusters of multidrug resistant Pseudomonas aeruginosa in critically ill cancer patients. Am J Infect Control 37(6):442-6, 2009. e-Pub 2008. PMID: 19118923.
- Chemaly RF, Hanmod SS, Jiang Y, Rathod DB, Mulanovich V, Adachi JA, Rolston KV, Raad II, Hachem RY. Tigecycline use in cancer patients with serious infections: a report on 110 cases from a single institution. Medicine (Baltimore) 88(4):211-20, 2009. PMID: 19593226.
- Vigil KJ, Mulanovich VE, Chemaly RF, Tarrand J, Raad II, Adachi JA. Severe parainfluenza virus type 2 supraglottitis in an immunocompetent adult host: an unusual cause of a paramyxoviridae viral infection. J Intern Med 265(3):397-400, 2009. PMID: 19019183.
- Aisenberg G, Torres H, Tarrand J, Safdar A, Bodey G, Chemaly RF. Herpes Simplex Virus Lower Respiratory Tract Infection in Patients with Solid Tumors. Cancer 115(1):199-206, 2009. PMID: 19090003.
- Hachem RY, Kontoyiannis DP, Chemaly RF, Jiang Y, Reitzel R, Raad I. Utility of galactomannan enzyme immunoassay and (1,3) beta-D-glucan in diagnosis of invasive fungal infections: low sensitivity for Aspergillus fumigatus infection in hematologic malignancy patients. J Clin Microbiol 47(1):129-33, 2009. e-Pub 2008.
- Torres HA, Aguilera E, Safdar A, Rohatgi N, Raad II, Sepulveda C, Luna M, Kontoyiannis DP, Chemaly RF. Fatal cytomegalovirus pneumonia in patients with haematological malignancies: an autopsy-based case-control study. Clin Microbiol Infect 14(12):1160-6, 2008. PMID: 19046167.
- Ghanem G, Hachem RY, Chemaly RF, Dvorak T, Hulten K, Graviss L, Raad II. The role of molecular methods in the prevention of nosocomial methicillin-resistant Staphylococcus aureus clusters in cancer patients. Am J Infect Control 36(9):656-60, 2008. PMID: 18834742.
- Raad I, Reitzel R, Jiang Y, Chemaly RF, Dvorak T, Hachem R. Anti-adherence Activity and Antimicrobial Durability of Anti-infective-Coated Catheters Against Multidrug-Resistant Bacteria. J Antimicrob Chemother 62(4):746-50, 2008. PMID: 18653489.
- Winston DJ, Young JA, Pullarkat V, Papanicolaou GA, Vij R, Vance E, Alangaden GJ, Chemaly RF, Petersen F, Chao N, Klein J, Sprague K, Villano SA, Boeckh M. Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem-cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study. Blood 111(11):5403-10, 2008. PMID: 18285548.
- Lamaris GA, Esmaeli B, Chamilos G, Desai A, Chemaly RF, Raad II, Safdar A, Lewis RE, Kontoyiannis DP. Fungal endophthalmitis in a tertiary care cancer center: a review of 23 cases. Eur J Clin Microbiol Infect Dis 27(5):343-7, 2008. PMID: 18183439.
- Youssef S, Hachem R, Chemaly RF, Adachi J, Ying J, Rolston K, Raad I. The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer. J Antimicrob Chemother 61(2):421-4, 2008. PMID: 18174198.
- Chemaly RF, Torres HA, Hachem R, Kontoyiannis DP, Safdar A, Raad II. Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection. Haematologica 93(1):157-8, 2008. PMID: 18166808.
- Chemaly RF, Torres HA, Aguilera EA, Mattiuzzi G, Cabanillas M, Kantarjian H, Gonzalez V, Safdar A, Raad II. Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study. Clin Infect Dis 44(7):964-7, 2007. PMID: 17342649.
- Torres HA, Aguilera EA, Mattiuzzi GN, Cabanillas ME, Rohatgi N, Sepulveda CA, Kantarjian HM, Jiang Y, Safdar A, Raad II, Chemaly RF. Characteristics and Outcome of Respiratory syncytial virus infection in patients with leukemia. Haematologica 92(9):1216-1223, 2007. PMID: 17666367.
- Torres HA, Kontoyiannis DP, Aguilera EA, Younes A, Luna MA, Tarrand JJ, Nogueras GM, Raad II, Chemaly RF. Cytomegalovirus infection in patients with lymphoma: an important cause of morbidity and mortality. Clin Lymphoma Myeloma 6(5):393-8, 2006. PMID: 16640816.
- Chemaly, RF, Gosh S, Bodey GP, et al. Respiratory Viral Infections in Adults With Hematologic Malignancies and Human Stem Cell Transplantation Recipients A Retrospective Study at a Major Cancer Center. Medicine (Baltimore) 85(5):278-287, 2006.
- Torres HA, Kontoyiannis DP, Bodey GP, Adachi JA, Luna MA, Tarrand JJ, Nogueras GM, Raad II, Chemaly RF. Gastrointestinal cytomegalovirus disease in patients with cancer: a two decade experience in a tertiary care cancer center. Eur J Cancer 41(15):2268-79, 2005. PMID: 16143517.
- Chemaly RF, Yen-Lieberman B, Chapman J, et al. Clinical utility of cytomegalovirus viral load in bronchoalveolar lavage in lung transplant recipients. Am J Transplant 5(3):544-8, 2005. PMID: 15707409.
- Chemaly RF, Torres HA, Hachem RY, et al. Cytomegalovirus pneumonia in patients with lymphoma. Cancer 104(6):1213-20, 2005. PMID: 16078263.
- Chemaly RF, Yen-Lieberman B, Castilla EA, Reilly A, Arrigain S, Farver C, Avery RK, Gordon SM, Procop GW. Correlation between viral loads of cytomegalovirus in blood and bronchoalveolar lavage specimens from lung transplant recipients determined by histology and immunohistochemistry. J Clin Microbiol 42(5):2168-72, 2004. PMID: 15131185.
- Chemaly RF, Yen-Lieberman B, Schindler SA, Goldfarb J, Hall GS, Procop GW. Rotaviral and bacterial gastroenteritis in children during winter: an evaluation of physician ordering patterns. J Clin Virol 28(1):44-50, 2003. PMID: 12927750.
- Hicks KL, Chemaly RF, Kontoyiannis DP. Common community respiratory viruses in patients with cancer: more than just "common colds". Cancer 97(10):2576-87, 2003. PMID: 12733157.
- Liu W, Chemaly RF, Tuohy MJ, LaSalvia MM, Procop GW. Pasteurella multocida urinary tract infection with molecular evidence of zoonotic transmission. Clin Infect Dis 36(4):E58-60, 2003. PMID: 12567321.
- Chemaly RF, de Parres JB, Rehm SJ, Adal KA, Lisgaris MV, Katz-Scott DS, Curtas S, Gordon SM, Steiger E, Olin J, Longworth DL. Venous thrombosis associated with peripherally inserted central catheters: a retrospective analysis of the Cleveland Clinic experience. Clin Infect Dis 34(9):1179-83, 2002. PMID: 11941543.
- Chemaly RF, Tomford JW, Hall GS, Sholtis M, Chua JD, Procop GW. Rapid diagnosis of Histoplasma capsulatum endocarditis using the AccuProbe on an excised valve. J Clin Microbiol 39(7):2640-1, 2001. PMID: 11427583.
- Shah DP, Ghantoji SS, Ariza-Heredia EJ, Shah JN, El Taoum KK, Shah PK, Nesher L, Hosing C, Rondon G, Champlin RE, Chemaly RF. An Immunodeficiency Scoring Index to predict poor outcomes in hematopoietic cell transplant recipients with respiratory syncytial virus infections. Blood. e-Pub 2014. PMID: 24700783.
- Torres HA, Rallapalli V, Saxena A, Granwehr BP, Viola GM, Ariza-Heredia E, Adachi JA, Chemaly RF, Marfatia R, Jiang Y, Mahale P, Kyvernitakis A, Fanale MA, Mulanovich V. Efficacy and Safety of Antiretrovirals in HIV-Infected Patients with Cancer. Clin Microbiol Infect. e-Pub 2014. PMID: 24529214.
- Mahajan SN, Ariza-Heredia EJ, Rolston KV, Graviss LS, Feig BW, Aloia TA, Chemaly RF. Perioperative Antimicrobial Prophylaxis for Intra-abdominal Surgery in Patients with Cancer: A Retrospective Study Comparing Ertapenem and Nonertapenem Antibiotics. Ann Surg Oncol. e-Pub 2013. PMID: 24114052.
- Wilhelm K, Chemaly R, Saliba R, Gulbis A, Saunders I, Cool R, Ferguson J, Westmoreland M, Rondon G, Kebriaei P. The impact of pre-transplant valganciclovir on early cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation. J Oncol Pharm Pract. e-Pub 2013. PMID: 24022408.
- El Chaer F, Shah DP, Kmeid J, Ariza-Heredia EJ, Hosing CM, Mulanovich VE, Chemaly RF. Burden of human metapneumovirus infections in patients with cancer: Risk factors and outcomes. Cancer. e-Pub 2017. PMID: 28178369.
- Grimley MS, Chemaly RF, Englund JA, Kurtzberg J, Chittick G, Brundage TM, Bae A, Morrison ME, Prasad VK. Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial. Biol Blood Marrow Transplant. e-Pub 2017. PMID: 28063938.
- El Chaer F, Mori N, Shah D, Oliver N, Wang E, Jan A, Doan V, Tverdek F, Tayar J, Ariza-Heredia E, Chemaly RF. Adjuvant and salvage therapy with leflunomide for recalcitrant cytomegalovirus infections in hematopoietic cell transplantation recipients: A case series. Antiviral Res 135:91-96. e-Pub 2016. PMID: 27594527.
- Langman LJ, Nesher L, Shah DP, Azzi JM, Shpall EJ, Rezvani K, Black JL, Chemaly RF. Challenges in Determining Genotypes for Pharmacogenetics in Allogeneic Hematopoietic Cell Transplant Recipients. J Mol Diagn. e-Pub 2016. PMID: 27371869.
- Aitken SL, Tarrand JJ, Deshpande LM, Tverdek FP, Jones AL, Shelburne SA, Prince RA, Bhatti MM, Rolston KV, Jones RN, Castanheira M, Chemaly RF. High rates of non-susceptibility to ceftazidime-avibactam and identification of New Delhi metallo-β-lactamase production in Enterobacteriaceae bloodstream infections at a major cancer center. Clin Infect Dis. e-Pub 2016. PMID: 27313265.
- Ariza-Heredia EJ, Azzi J, Shah DP, Nesher L, Ghantoji SS, Michailidis L, Marsh L, Chemaly RF. Influenza Vaccination in Patients With Cancer: Factors Associated With Vaccination Practices for Patients and Their Household Members. Infect Control Hosp Epidemiol:1-3. e-Pub 2015. PMID: 26132392.
- Saliba RM, Rezvani K, Leen A, Jorgensen J, Shah N, Hosing C, Parmar S, Oran B, Olson A, Rondon G, Chen J, Martinez C, Hamdi A, Mehta RS, Chemaly R, Saunders IM, Bollard CM, Shpall EJ. General and Virus-Specific Immune Cell Reconstitution after Double Cord Blood Transplantation. Biol Blood Marrow Transplant. e-Pub 2015. PMID: 25708219.
- Chemaly RF, Dadwal SS, Bergeron A, Ljungman P, Kim YJ, Cheng GS, Pipavath SN, Limaye AP, Blanchard E, Winston DJ, Stiff PJ, Zuckerman T, Lachance S, Rahav G, Small CB, Mullane KM, Patron RL, Lee DG, Hirsch HH, Waghmare A, McKevitt M, Jordan R, Guo Y, German P, Porter DP, Gossage DL, Watkins TR, Marty FM, Chien JW, Boeckh M. A phase 2, randomized, double-blind, placebo-controlled trial of presatovir for the treatment of respiratory syncytial virus upper respiratory tract infection in hematopoietic-cell transplant recipients. Clin Infect Dis. e-Pub 2019. PMID: 31793991.
- El Haddad L, Ghantoji SS, Park AK, Batista M, Schelfhout J, Hachem J, Lobo Y, Jiang Y, Rondon G, Champlin R, Chemaly RF. Clinical and Economic Burden of Pre-emptive Therapy of Cytomegalovirus Infection in Hospitalized Allogeneic Hematopoietic Cell Transplant Recipients. J Med Virol. e-Pub 2019. PMID: 31448830.
- Sheshadri A, Chemaly RF, Alousi AM, Shah PK, Rondon G, Bashoura L, Kmeid J, Azzi J, Blanco DW, Kaous M, Dickey BF, Champlin RE, Shah DP. Pulmonary impairment following respiratory viral infections is associated with high mortality in allogeneic hematopoietic cell transplant recipients. Biol Blood Marrow Transplant. e-Pub 2018. PMID: 30521974.
- El Haddad L, Ariza-Heredia E, Shah DP, Jiang Y, Blanchard T, Ghantoji SS, El Chaer F, El-Haddad D, Prayag A, Nesher L, Rezvani K, Shpall E, Chemaly RF. The Ability of a Cytomegalovirus ELISPOT Assay to Predict Outcome of Low-Level CMV Reactivation in Hematopoietic Cell Transplant Recipients. J Infect Dis. e-Pub 2018. PMID: 30295846.
- Foolad F, Aitken SL, Shigle TL, Prayag A, Ghantoji S, Ariza-Heredia E, Chemaly RF. Oral versus Aerosolized Ribavirin for the Treatment of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplantation Recipients. Clin Infect Dis. e-Pub 2018. PMID: 30202920.
- Chemaly RF, Chou S, Einsele H, Griffiths P, Avery R, Razonable RR, Mullane KM, Kotton C, Lundgren J, Komatsu TE, Lischka P, Josephson F, Douglas CM, Umeh O, Miller V, Ljungman P, Resistant Definitions Working Group of the Cytomegalovirus Drug Development Forum. Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials. Clin Infect Dis. e-Pub 2018. PMID: 30137245.
- Vakil E, Sheshadri A, Faiz SA, Shah DP, Zhu Y, Li L, Kmeid J, Azzi J, Balagani A, Bashoura L, Ariza-Heredia E, Chemaly RF. Risk factors for mortality after respiratory syncytial virus lower respiratory tract infection in adults with hematologic malignancies. Transpl Infect Dis:e12994. e-Pub 2018. PMID: 30195271.
- Azzi JM, Kyvernitakis A, Shah DP, El Haddad L, Mahajan SN, Ghantoji SS, Heredia-Ariza E, Chemaly RF. Leukopenia and lack of ribavirin predict poor outcomes in patients with haematological malignancies and respiratory syncytial virus infection. J Antimicrob Chemother. e-Pub 2018. PMID: 30113677.
- Marty FM, Ljungman P, Chemaly RF, Maertens J, Dadwal SS, Duarte RF, Haider S, Ullmann AJ, Katayama Y, Brown J, Mullane KM, Boeckh M, Blumberg EA, Einsele H, Snydman DR, Kanda Y, DiNubile MJ, Teal VL, Wan H, Murata Y, Kartsonis NA, Leavitt RY, Badshah C. Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation. N Engl J Med. e-Pub 2017. PMID: 29211658.
- Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Sloane RS, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Sanchez EMR, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, Austin-Breneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. e-Pub 2017. PMID: 29097493.
- Vilar-Compte D, Shah DP, Vanichanan J, Cornejo-Juarez P, Garcia-Horton A, Volkow P, Chemaly RF. Influenza in Patients with Hematological Malignancies: Experience at Two Comprehensive Cancer Centers. J Med Virol. e-Pub 2017. PMID: 28851056.
Invited Articles
- Chemaly RF, Hill JA, Voigt S, Peggs KS. In vitro comparison of currently available and investigational antiviral agents against pathogenic human double-stranded DNA viruses: A systematic literature review. Antiviral Res 163:50-58, 2019. e-Pub 2019. PMID: 30677427.
- Foolad F, Aitken SL, Chemaly RF. Letermovir for the prevention of cytomegalovirus infection in adult cytomegalovirus-seropositive hematopoietic stem cell transplant recipients. Expert Rev Clin Pharmacol 11(10):931-941, 2018. e-Pub 2018. PMID: 30004790.
- Ariza-Heredia EJ, Chemaly RF. Update on infection control practices in cancer hospitals. CA Cancer J Clin 68(5):340-355, 2018. e-Pub 2018. PMID: 29985544.
- Chemaly RF, Shah DP, Boeckh MJ. Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies. Clin Infect Dis 59 Suppl 5:S344-51, 2014. PMID: 25352629.
- Ariza-Heredia EJ, Chemaly RF. Infection Control Practices in Patients With Hematological Malignancies and Multidrug-Resistant Organisms: Special Considerations and Challenges. Clinical Lymphoma, Myeloma & Leukemia 14(S3):104-10, 2014.
- El Chaer F, Shah DP, Chemaly RF. How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients. Blood. e-Pub 2016. PMID: 27760756.
- Shah DP, Shah PK, Azzi JM, El Chaer F, Chemaly RF. Human metapneumovirus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: A systematic review. Cancer Lett. e-Pub 2016. PMID: 27260872.
- Khawaja F, Batista MV, El Haddad L, Chemaly RF. Resistant or refractory cytomegalovirus infections after hematopoietic cell transplantation: diagnosis and management. Curr Opin Infect Dis. e-Pub 2019. PMID: 31567572.
- Khawaja F, Chemaly RF. Respiratory syncytial virus in hematopoietic cell transplant recipients and hematologic malignancy patients. Haematologica. e-Pub 2019. PMID: 31221784.
- El Haddad L, Harb CP, Gebara MA, Stibich MA, Chemaly RF. A Systematic and Critical Review of Bacteriophage Therapy against Multi-Drug Resistant ESKAPE Organisms in Humans. Clin Infect Dis. e-Pub 2018. PMID: 30395179.
- Batista MV, Haddad LE, Chemaly RF. Paramyxovirus infections in hematopoietic cell transplant recipients. Curr Opin Infect Dis. e-Pub 2018. PMID: 30320640.
Abstracts
- Chemaly RF, Moss R, Marty Francisco, et.al. A randomized, double-blind, placebo-controlled multicenter phase 2 trial to examine the effects of DAS181 in immunocompromised (IC) patients with parainfluenza virus (PIV) lower respiratory tract infection (LRTI) on supplemental oxygen (SO). Oral presentation at ID Week, 2018.
- S. L. Aitken, J. Zhou, S. S. Ghantoji, D. P. Kontoyiannis, R. N. Jones, V. H. Tam, R. F. Chemaly. Pharmacokinetics (PK) and Safety of Intravesicular Cidofovir. Poster Presentation at ICAAC, 55th Annual Meeting of the American Society for Microbiology, Interscience Conference on Antimicrobial Agents and Chemotherapy, 2015.
Grant & Contract Support
| Title: | Clinical Experience With Tigecycline |
| Funding Source: | Wyeth Pharmaceuticals |
| Role: | Principal Investigator |
| Title: | A Randomized, Double -Blind, Placebo-Controlled Study To Assess The Efficacy And Safety of Prophylactic Use of Maribavir For The Prevention of Cytomegalovirus Disease in Recipients of Allogeneic Stem Cell Transplants |
| Funding Source: | Viropharm Inc |
| Role: | Principal Investigator |
| Title: | An Open-Label, Multi-Center, Single Arm Study to Evaluate the Safety and Tolerability of Intravenous Zanamivir in the Treatment of Hospitalized Adult, Adolescent and Pediatric Subjects with Confirmed Influenza Infection.(NAI113678) |
| Funding Source: | Glaxo Smith and Kline |
| Role: | Principal Investigator |
| Title: | A Randomized Double-blind, Placebo-controlled Trial to Evaluate The Safety, Tolerability, and Antiviral Activity of 12-weeks Treatment With a New Antiviral Drug |
| Funding Source: | Aicuris |
| Role: | Principal Investigator |
| Title: | 1%, Phase III, Randomized, Placebo control Clinical Trial to Evaluate the Safety and Efficacy of MK-8228 (Letermovir) for the Prevention of Clinically Significant Human Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients |
| Funding Source: | Merck Sharp and Dohme Corp |
| Role: | Principal Investigator-MDACC |
| Title: | A Companion Protocol to the Clinical Study a Randomized, Placebo-controlled, Multi-site Phase II Study Evaluating the Safety and Efficacy of Preemptive Treatment with CMX001 for the Prevention of Adenovirus Disease Following Hematopoietic Stem Cell Transplantation (CMX001-202 Lab) |
| Funding Source: | Chimerix, Inc |
| Role: | Principal Investigator |
| Title: | A Phase III International, Randomized, Double-blind, Double Dummy Study to Evaluate the Efficacy and Safety of 300 mg or 600 mg of Intravenous Zanamivir Twice Daily Compared to 75 mg of Oral Oseltamivir Twice Daily in the Treatment of Hospitalized Adults and Adolescents with Influenza |
| Funding Source: | Glaxo Smith and Kline |
| Role: | Principal Investigator |
| Title: | A Prospective Observational Study for the Long-Term Follow-up of Subjects Previously Enrolled in Selected Clinical Studies of CMX001 (333) (PA14-0993) |
| Funding Source: | Chimerix, Inc |
| Role: | Principal Investigator-MDACC |
| Title: | A randomized, open label, multi-center, comparative trial, to assess the efficacy and safety of pritelivir versus foscarnet for the treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised adults (PRIOH-1), CS2017-0146, |
| Funding Source: | Aicuris |
| Role: | Principal Investigator-MDACC |
| Title: | The role of Bacteriophages in HCT Recipients |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Principal Investigator-MDACC |
| Title: | The use of Viracor © CMV T Cell Immunity Panel to Assess the Risk of CMV Infection in Hematopoeitic Cell Transplant Recipients with Low Level CMV Viremia. CS2018-1146 |
| Funding Source: | Viracor, Inc |
| Role: | Principal Investigator-MDACC |
| Title: | A Phase 3, Open-Label, Multicenter Study of the Safety and Efficacy of Brincidofovir (CMX001) in the Treatment of Early versus Late Adenovirus Infection |
| Funding Source: | Chimerix, Inc |
| Role: | Principal Investigator-MDACC |
| Title: | Isolation of Bacteriophages against prevalent Multidrug Resistant Organisms in 3 Geographical Regions: Impact on Stem Cell Transplant Recipients Outcomes |
| Funding Source: | The Sister Institution Network Fund (SNIF) |
| Role: | Principal Investigator-MDACC |
| Title: | Evaluation of Retained Immunity for Tetanus-Diphteria-Pertussis (Tdap) and Pneumococcus Vaccines in Surviviors of CART or TCR Therapy |
| Funding Source: | Institutional Research Grant |
| Role: | Co-Investigator |
| Title: | The Role of Bacteriphages in Hematopoeitic Cell Transplant Recipients |
| Funding Source: | Institutional Research Grant |
| Role: | Principal Investigator |
| Title: | A multi-size, randomized trial of subject-collected dried blood spot CMV testing with mobile technology support to optomize preemptive therapy late after allogeneic HCT, CS2017-1076 |
| Funding Source: | Fred Hutchison |
| Role: | Principal Investigator-MDACC |
| Title: | A Phase III Randomized Double-Blinded Placebo Controlled Study to Examine the Effects of DAS181 for the Treatment of Lower Respiratory Tract Parainfluenza Infection in Immunocompromised Subjects |
| Funding Source: | Ansun Pharmaceuticals |
| Role: | Principal Investigator |
| Title: | Mentored Research Scientist Career Development Award |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Mentor |
| Title: | Mentored Research Scientist Career Development Award |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Mentor |
| Title: | The interplay of the immune system, and microbiome in determining outcome of respiratory viral infec-tions in hematopoietic cell transplant recipients and in patients with leukemia |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |