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      Ryan W. Huey Image

      Ryan W. Huey, MD, MS

      Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine

      About Dr. Ryan W. Huey

      Dr. Ryan Huey is a GI Medical Oncologist and serves as the Deputy Division Head for Clinical Quality and Effectiveness in the Division of Cancer Medicine. He sees patients with gastrointestinal cancers and his clinical research focuses on Cancer of Unknown Primary. He has published work describing distinct cohorts of this rare cancer and is actively investigating novel diagnostic and treatment approaches. He has led numerous institutional initiatives focused on quality and cancer care delivery, including efforts to reduce acute care utilization among patients receiving chemotherapy (OP-35), reduce readmissions, and evaluate remote patient monitoring.

      Read More

      Talking to loved ones about advance care planning

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      In the News

      Cartoon man bundled up against cold shivers next to oversized thermometer

      How to cope with cold sensitivity due to chemotherapy

      Woman touching her neck in pain

      What is mucositis? 4 things to know about this cancer treatment side effect

      Ryan Huey, M.D., speaks with a patient while wearing a face shield over a medical-grade face mask.

      How to cope with cold sensitivity during chemotherapy

      Present Title & Affiliation

      Primary Appointment

      Deputy Division Head, Clinical Quality and Effectiveness, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas

      Associate Professor, GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas

      Education & Training

      Degree-Granting Education

      2023University of Texas at Austin, Austin, Texas, US, Health Care Transformation, MS
      2012University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, US, MD
      2008Texas Christian University, Fort Worth, Texas, US, Biology, BA

      Postgraduate Training

      2016-2019Clinical Fellowship, Hematology and Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
      2012-2015Clinical Residency, Internal Medicine, Duke University Medical Center, Durham, North Carolina

      Licenses & Certifications

      2023Physician Advisor Subspeciality Certification, Health Care Quality and Management
      2023Certification in Health Care Quality and Management
      2019Hematology Board Certification
      2019Medical Oncology Board Certification
      2016Texas Medical Board
      2015Internal Medicine Board Certification

      Experience & Service

      Faculty Academic Appointments

      Assistant Professor, GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2019 - 2025

      Instructor, Duke University Medical Center, Durham, NC, 2015 - 2016

      Administrative Appointments/Responsibilities

      Patient Safety and Quality Officer, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2026 - Present

      Associate Medical Director, Colorectal Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present

      Physician Advisor – Operational Medical Director, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - Present

      Vizient Champion, GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2022 - Present

      Scholar, Institute for Cancer Care Innovation, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2019

      Intramural Institutional Committee Activities

      Member, Executive Committee of the Medical Staff, The University of Texas MD Anderson Cancer Center, 2025 - Present

      Chair, Utilization Review, The University of Texas MD Anderson Cancer Center, 2025 - Present

      Co-Lead, DPYD Testing Prior to Fluoropyrimidine Chemotherapy, The University of Texas MD Anderson Cancer Center, 2025 - Present

      Lead, Readmissions Reduction Solid Tumor Task Force, The University of Texas MD Anderson Cancer Center, 2025 - Present

      Director, Cancer of Unknown Primary Tumor Board, The University of Texas MD Anderson Cancer Center, 2024 - Present

      Vice Chair, Utilization Review Committee, The University of Texas MD Anderson Cancer Center, 2022 - 2025

      Member, Utilization Review Committee, The University of Texas MD Anderson Cancer Center, 2019 - Present

      Extramural Institutional Committee Activities

      Member, ASCO Pain Patient Report Outcome Performance Measure Committee, American Society for Clinical Oncology, 2026 - Present

      Member, Schwartz Rounds Planning Committee, The University of Texas MD Anderson Cancer Center, 2023 - 2025

      Honors & Awards

      2024Center for Professionalism Support & Success (CPSS) Award for Professional Excellence (APEX), The University of Texas MD Anderson Cancer Center
      2019Conquer Cancer Foundation of ASCO Merit Award
      2018LBJ Hospital 2nd Year Fellow of the Year Award, The University of Texas MD Anderson Cancer Center
      2018NCCN Fellows Recognition Program
      2012F. Daniel Duffy, M.D. Internal Medicine Award, University of Oklahoma College of Medicine
      2011Podalirian Award, University of Oklahoma College of Medicine
      2011Gold Humanism Honor Society
      2008Jean J. and William Tucker Award for Leadership and Service, Texas Christian University
      2008Janet Perry Award for Overcoming Adversity, Texas Christian University
      2008Phi Beta Kappa, Texas Christian University

      Professional Memberships

      American Society of Clinical Oncology

      2014 - Present

      Association of American Medical Colleges

      2009 - 2012

      Selected Presentations & Talks

      National Presentations

      1. 2025. Performance Characteristics of CMS' OP-35 Quality Measure: Sensitive but not Specific. Conference. ASCO Quality Care Symposium. Chicago, Illinois, US.
      2. 2025. Clinical Utility of Blood-based Profiling Strategy for Site-of-Origin Determination in CUP: The CRONUS Study. Invited. International Cancer of Unknown Primary Meeting. Berlin, DE.
      3. 2025. Cancer signal origin (CSO) prediction in cancer of unknown primary (CUP) syndrome (CRONUS) using circulating tumor DNA (ctDNA). Poster. ESMO Congress 2025. Berlin, DE.
      4. 2025. OP-35: Does a tool designed to measure potentially preventable chemotherapy toxicities do so effectively?. Poster. ASCO Annual Meeting 2025. Chicago, Illinois, US.
      5. 2025. Phase II Trial of Sintilimab in Cancer of Unknown Primary. Poster. ASCO GI 2025. San Francisco, California, US.
      6. 2024. Clinical Characterization and Outcomes of Patients with PAX8 Positive Cancer of Unknown Primary: A Distinct Immunophenotypic Subset. Poster. ESMO Asia 2024. Singapore, SG.
      7. 2024. OP-35: Reducing Patient Returns to the Emergency Center. Vizient Connections Summit 2025. Las Vegas, Nevada, US.
      8. 2023. Value Based Care in Oncology, Does It Measure Up?. Value-Based Cancer Care Symposium, US.
      9. 2023. Financial Toxicity in Cancer. Patient-Centered Oncology Care Conference, US.
      10. 2023. Keynote Address and Panel Facilitation. Value Based Care in Oncology, Does It Measure Up?. Vizient Pharmacy Network Meeting, US.
      11. 2023. Digital Healthcare Technology: A Robust Growth Sector. Association for Value-Based Cancer Care Conference, US.
      12. 2021. Keynote Address. Innovations in diagnosing and treating cancer: What are the barriers to access for patients?. Bayer Pharmaceuticals, US.

      International Presentations

      1. 2020. Mind the Gap: Precision Oncology and Its Potential to Widen Disparities. AATS International Thoracic Surgical Oncology Summit 2020, US.

      Formal Peers

      1. 2020. Lecturer, Value and Quality in Healthcare. Clinical Skills and Effectiveness Course. Houston, Texas, US.
      2. 2020. Lecturer, Systemic Therapy in GI Malignancies, Radiation Oncology Resident Lecture Series. Houston, Texas, US.
      3. 2018. Instructor, Coffee and Conversations / Fellows’ Communication Series. Houston, Texas, US.
      Read More
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      Grant & Contract Support

      Date: 2022 - 2029
      Title:A Multicenter, Open-label, Phase 1a/b Study of HC-7366 in Subjects With Advanced Solid Tumors
      Funding Source:HiberCell, Inc
      Role:Co-I
      ID:2021-1093 | PID13559
      Date: 2021 - 2028
      Title:STRATEGIC ALLIANCE: 2020-0902-A Phase 2 Clinical Trial Evaluating the Efficacy and Safety of Sintilimab for Advanced Rare Cancers (SiARa Cancer Study) – Cancer of Unknown Primary (SiARa-CUP)
      Funding Source:Innovent Biologics
      Role:Collaborator
      ID:2020-0902 | PID 123971

      Selected Publications

      Peer-Reviewed Articles

      1. Lapelusa, M, Shah, P, Bhamidipati, D, Kui, N, Bent, AH, Dasari, NV, Huey, RW, Kee, BK, Kopetz, S, Le, PH, Ludford, K, Morelli, MP, Morris, VK, Parseghian, C, Raghav, KS, Willis, JA, Wolff, RA, Zhao, D, Overman, MJ, Serpas Higbie, V. Patterns of progression and survival in patients with mismatch repair deficient/ microsatellite instability- high metastatic colorectal cancer treated with immunotherapy. Oncologist 31(8), 2026. e-Pub 2026. PMID: 42475509.
      2. Lim, M, Grandhi, N, Shah, P, Raghav, KS, Serpas Higbie, V, Morelli, MP, Pedersen, KS, Kalyan, A, Salem, ME, Huey, RW, Shen, JY, Wang, H, Wang, H, Vinocha, A, Thomas, J, Wolff, RA, Overman, MJ. A retrospective analysis of taxane-based chemotherapy in small bowel adenocarcinoma. Oncologist 31(5), 2026. e-Pub 2026. PMID: 41871440.
      3. Uprety, D, Sweeney, K, Arjyal, L, Hadid, T, Shields, AF, Lieu, C, Huey, RW, Raghav, KS, Elliott, A, Fountain, MD, Oberley, MJ, Subbiah, V, Seeber, A. Real-World Biomarker-Associated Therapy in Metastatic Carcinoma of Unknown Primary. JNCCN Journal of the National Comprehensive Cancer Network 24(4), 2026. e-Pub 2026. PMID: 41911910.
      4. Haldar, SD, Saj, F, Hong, SJ, Surana, R, Xiao, L, Lee, JJ, Smaglo, BG, Zhao, D, Zhu, H, Huey, RW, Willis, JA, Morelli, MP, Overman, MJ, McAllister, F, Wolff, RA, Maitra, A, Fogelman, D, Der, CJ, Pant, S. Phase I trial of binimetinib plus hydroxychloroquine in patients with previously treated metastatic pancreatic cancer. Oncologist 31(4), 2026. e-Pub 2026. PMID: 41761573.
      5. Song, Y, Allam, J, Beaty, K, Willett, A, Taggart, MW, Malpica, A, Royal, RE, Mansfield, PF, Huey, RW, Raghav, KS, Fournier, KF, Helmink, BA. Perioperative outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy following neoadjuvant systemic therapy for high-volume peritoneal mesothelioma. Surgical Oncology Insight 3(1), 2026. e-Pub 2026.
      6. Pattalachinti, V, Haque, E, Yousef, M, Yousef, A, Chowdhury, S, Overman, MJ, Parseghian, C, Morris, VK, Kee, BK, Huey, RW, Raghav, KS, Court, CM, Shen, JY. BRAF mutant appendiceal adenocarcinoma differs from colorectal cancer but responds to BRAF-targeted therapy. npj Precision Oncology 9(1), 2025. e-Pub 2025. PMID: 39910160.
      7. Waters Jackson, L, Huey, RW, Manzano, JM, Pantoja, L, Skinner, N, Bivens, D, Rivera, J, Adelson, K. Transitional care management for cancer patients. JCO Oncology Practice 21:282, 2025. e-Pub 2025.
      8. Morris, VK, Parseghian, C, Bahrambeigi, V, Abdelfattah, N, Xiao, L, Agrawal, A, Lin, K, Raghav, KS, Wolff, RA, Dasari, NV, Huey, RW, Kee, BK, Overman, MJ, Willis, JA, Le, PH, Escano, M, Baig, YC, Pan, K, Menter, DG, Tam, AL, Foo, WC, Shen, L, Lee, HM, Gallup, T, Margain, C, Gallup, D, Rajapakshe, K, Guerrero, PA, Wang, J, Corcoran, RB, Maitra, A, Yun, K, Kopetz, S. Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer. Cancer cell 43(11):2106-2118.e3, 2025. e-Pub 2025. PMID: 40882637.
      9. Huey, RW, Zafar, A, Le, PH, Sanchez, NE, Patlovich, K, Olivieri, ND, Overman, MJ, Rivera, J, Roux, R, Adelson, K. Performance characteristics of CMS' OP-35 quality measure. JCO Oncology Practice 21:421, 2025. e-Pub 2025.
      10. Pellatt, AJ, Bent, AH, Hornstein, N, Parseghian, C, Huey, RW, Raghav, KS, Morris, VK, Overman, MJ, Morelli, P, Willis, JA, Le, PH, Shen, JY, Kee, BK, Eluri, M, Higbie, V, Alfaro-Munoz, KD, Aziz, KE, Kell, R, Sun, R, Kopetz, S, Dasari, NV. Phase II Trial of TAS-102 in Colorectal Cancer Patients With Circulating Tumor DNA-Defined Minimal Residual Disease After Adjuvant Therapy. JCO Precision Oncology 9, 2025. e-Pub 2025. PMID: 40669021.
      11. Morris, VK, Xiao, W, Lin, K, Wong, CW, Wotman, MT, Holliday, EB, Huey, RW, Noticewala, SS, Ludmir, EB, Bent, AH, Ludford, K, Messick, C, Koay, EJ, Smith, GL, Konishi, T, Bednarski, BK, Chang, GJ, Koong, A, You, YN, Das, P, Gillison, M. Time Dependency for Human Papillomavirus Circulating Tumor DNA Detection after Chemoradiation as a Prognostic Biomarker for Localized Anal Cancer. Clinical Cancer Research 31(12):2399-2405, 2025. e-Pub 2025. PMID: 39873618.
      12. Shah, P, Raghav, KS, Serpas Higbie, V, Pedersen, KS, Kalyan, A, Salem, ME, Huey, RW, Shen, JY, Wang, H, Wang, H, Vinocha, A, Thomas, J, Wolff, RA, Overman, MJ. A retrospective analysis of taxane-based chemotherapy in small bowel adenocarcinoma (SBA). Journal of Clinical Oncology 43:e16479-e16479, 2025. e-Pub 2025.
      13. Grewal, K, Pant, S, Hu, I, Eluri, M, An, AW, Serpas Higbie, V, Huey, RW, Kasab, A, Javle, M, Lee, S. CLO25-099. Journal of the National Comprehensive Cancer Network : JNCCN 23(35), 2025. e-Pub 2025. PMID: 40154395.
      14. Peddireddy, A, Huey, RW, Wolff, RA, Lin, K, Mitchell, J, Scofield, LC, Jacob, S, Nguyen, DV, Rogers, JE, Portier, S, Foo, WC, Eng, C, Morris, VK. Clinicopathologic Features Associated with Survival for Immune Checkpoint Blockade in Patients with Metastatic Anal Cancer. Cancers 17(6), 2025. e-Pub 2025. PMID: 40149273.
      15. Pizuorno Machado, A, Adames, SM, Shatila, M, Aujla, P, Huey, RW, Wang, Y, Thomas, AS. Immune checkpoint inhibitor-associated gastrointestinal adverse events in patients with colorectal cancer. Annals of Gastroenterology 38(1):72-79, 2025. e-Pub 2025. PMID: 39802282.
      16. Bhamidipati, D, Johnson, JR, Lin, K, Pelicano, H, Eng, C, Huey, RW, Wolff, RA, Halperin, DM, Frumovitz, M, Wistuba, II, Duose, D, Mallampati, S, Luthra, R, Morris, VK. The Clinical Utility of a Next-Generation Sequencing-Based Approach to Detecting Circulating HPV DNA in Patients with Advanced Anal Cancer. Cancers 17(2), 2025. e-Pub 2025. PMID: 39858090.
      17. Yousef M, Yousef A, Chowdhury S, Fanaeian MM, Knafl M, Peterson J, Zeineddine M, Alfaro K, Zeineddine F, Goldstein D, Hornstein N, Dasari A, Huey R, Johnson B, Higbie V, Bent A, Kee B, Lee M, Morelli MP, Morris VK, Halperin D, Overman MJ, Parseghian C, Vilar E, Wolff R, Raghav KP, White MG, Uppal A, Sun R, Wang W, Kopetz S, Willis J, Shen JP. Molecular, Socioeconomic, and Clinical Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival. JAMA Oncol 10(11), 2024. e-Pub 2024. PMID: 39264607.
      18. Ludmir EB, Sherry AD, Fellman BM, Liu S, Bathala T, Haymaker C, Medina-Rosales MN, Reuben A, Holliday EB, Smith GL, Noticewala SS, Nicholas S, Price TR, Martin-Paulpeter RM, Perles LA, Lee SS, Lee MS, Smaglo BG, Huey RW, Willis J, Zhao D, Cohen L, Taniguchi CM, Koay EJ, Katz MHG, Wolff RA, Das P, Pant S, Koong AC, Tang C. Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial. J Clin Oncol 42(32):JCO2400081, 2024. e-Pub 2024. PMID: 39102622.
      19. Cass SH, Tzeng CD, Prakash LR, Maxwell J, Snyder RA, Kim MP, Huey RW, Smaglo BG, Pant S, Koay EJ, Wolff RA, Lee JE, Katz MHG, Ikoma N. Trends Over Time in Recurrence Patterns and Survival Outcomes after Neoadjuvant Therapy and Surgery for Pancreatic Cancer. Ann Surg. e-Pub 2024. PMID: 38506042.
      20. Johnson B, Morris V, Wang X, Dasari A, Raghav K, Shen JP, Lee MS, Huey R, Parseghian C, Willis J, Wolff R, Drusbosky LM, Overman MJ, Kopetz S. Comprehensive Landscape of BRAF Variant Classes, Clonalities, and Co-Mutations in Metastatic Colorectal Cancer Using ctDNA Profiling. Cancers (Basel) 16(4), 2024. e-Pub 2024. PMID: 38398128.
      21. Higbie, V, Shah, P, Bent, AH, Dasari, NV, Huey, RW, Johnson, B, Kee, BK, Kopetz, S, Lee, MS, Ludford, K, Morelli, MP, Morris, VK, Parseghian, C, Raghav, KS, Shen, JY, Willis, JA, Wolff, RA, Overman, MJ. Natural history and patterns of progression for dMMR/MSI-H colorectal cancer treated with immune checkpoint blockade. Journal of Clinical Oncology 42(3), 2024. e-Pub 2024.
      22. Maddalena, G, Pellatt, AJ, Eluri, M, Parseghian, C, Aziz, KE, Alfaro, KD, Kell, R, Bent, AH, Huey, RW, Uppal, A, Konishi, T, Overman, MJ, Morelli, MP, Willis, JA, Shen, JY, Raghav, KS, Newhook, TE, Morris, VK, Dasari, NV, Kopetz, S. INTERCEPT Program of circulating tumor DNA (ctDNA) testing for minimal residual disease (MRD) in colorectal cancer (CRC). Journal of Clinical Oncology 42(3_suppl):27, 2024. e-Pub 2024.
      23. Allam, J, Ma, L, Estrella, JS, Willett, A, Beaty, K, Matamoros Jr, A, Lano, EA, Fournier, KF, Treuner, K, Raghav, KS, Huey, RW. Utility of gene expression–based cancer classification in diagnosis of malignant peritoneal mesothelioma (MPeM). Journal of Clinical Oncology 42(3), 2024. e-Pub 2024.
      24. Morris, VK, Xiao, W, Holliday, EB, Lin, K, Huey, RW, Noticewala, SS, Ludmir, EB, Bent, AH, Higbie, V, Koay, EJ, Koong, A, Das, P, Gillison, M. Time dependency for HPV ctDNA detection as a prognostic biomarker for anal cancer. Journal of Clinical Oncology 42(16), 2024. e-Pub 2024.
      25. Pellatt, AJ, Maddalena, G, Bent, AH, Parseghian, C, Huey, RW, Raghav, KS, Morris, VK, Overman, MJ, Morelli, MP, Willis, JA, Le, PH, Shen, JY, Alfaro, KD, Aziz, KE, Kell, R, Sun, R, Kopetz, S, Dasari, NV. A phase II trial of TAS-102 in patients with colorectal cancer with ctDNA-defined minimal residual disease post-adjuvant therapy compared to synthetic control cohort. Journal of Clinical Oncology 42(16), 2024. e-Pub 2024.
      26. Huey RW, Shah AT, Reddi HV, Dasari P, Topham JT, Hwang H, Dhillon N, Willett A, Smaglo BG, Estrella JS, Rashid A, Matamoros A, Overman MJ, Choquette L, Omerza G, Kelly K, Wang X, Loree JM, Rueter J, Varadhachary GR, Raghav K. Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study. JournL National Cancer Inst 115(8):994-997, 2023. e-Pub 2023. PMID: 37202363.
      27. Rogers JE, Sirisaengtaksin A, Leung M, Morris VK, Xiao L, Huey R, Wolff R, Eng C, Vauthey JN, Tzeng CD, Johnson B. Hepatic Metastasectomy in Squamous Cell Carcinoma of the Anal Canal: A Case Series of a Curative Approach. Cancers (Basel) 15(15), 2023. e-Pub 2023. PMID: 37568706.
      28. Morris VK, Jazaeri A, Westin SN, Pettaway C, George S, Huey RW, Grinsfelder M, Shafer A, Johnson B, Vining D, Guo M, Fellman B, Frumovitz M. Phase II Trial of MEDI0457 and Durvalumab for Patients With Recurrent/Metastatic Human Papillomavirus-Associated Cancers. Oncologist 28(7):618-623, 2023. e-Pub 2023. PMID: 37104874.
      29. Zeineddine FA, Zeineddine MA, Yousef A, Gu Y, Chowdhury S, Dasari A, Huey RW, Johnson B, Kee B, Lee MS, Morelli MP, Morris VK, Overman MJ, Parseghian C, Raghav K, Willis J, Wolff RA, Kawaguchi Y, Vauthey JN, Sun R, Kopetz S, Shen JP. Survival improvement for patients with metastatic colorectal cancer over twenty years. NPJ Precision Oncology 7(1):16, 2023. e-Pub 2023. PMID: 36781990.
      30. Serpas Higbie V, Rogers J, Hwang H, Qiao W, Xiao L, Dasari A, Mola-Rudd K, Morris VK, Wolff RA, Raghav K, Huey R, Parseghian C, Willis J, Kopetz S, Overman MJ, Johnson B. Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response in MSI-H/dMMR Metastatic Colorectal Cancer: A Single-Center Experience. Oncologist 27(11):952-957, 2022. e-Pub 2022. PMID: 35946836.
      31. Morris VK, Overman MJ, Lam M, Parseghian CM, Johnson B, Dasari A, Raghav K, Kee BK, Huey R, Wolff RA, Shen JP, Li J, Zorrilla I, Tzeng CD, Tran Cao HS, Chun YS, Newhook TE, Vauthey N, Duose D, Luthra R, Haymaker C, Kopetz S. Bintrafusp alfa, an anti-PD-L1:TGF-β trap fusion protein, in patients with ctDNA-positive, liver-limited metastatic colorectal cancer. Cancer Res Commun 2(9):979-986, 2022. e-Pub 2022. PMID: 36382087.
      32. Johnson B, Yang D, Dada HI, Morris VK, Wang X, Dasari A, Singh Raghav KP, Kee BK, YC Shen JP, Huey R, Lee MS, Parseghian CM, Le P, Morelli MP, Willis J, Wolff RA, Drusbosky L, Overman MJ, Kopetz S. RAS co-mutation and early onset disease represent an aggressive phenotype of atypical (non-V600) BRAF mutant metastatic colorectal cancer. Journal of Clinical Oncology 40(16_suppl):3592-3592, 2022. e-Pub 2022.
      33. Parseghian CM, Sanchez EV, Sun R, Eluri M, Morris VK, Johnson B, Morelli MP, Overman MJ, Willis J, Huey R, Singh Raghav KP, Dasari A, Kee BK, Wolff RA, YC Shen JP, Kopetz S. Phase 2 study of anti-EGFR rechallenge therapy with panitumumab with or without trametinib in advanced colorectal cancer. Journal of Clinical Oncology 40(16_suppl):3520-3520, 2022. e-Pub 2022.
      34. Raghav KP, Stephen B, Karp DD, Piha-Paul SA, Hong DS, Jain D, Chudy Onwugaje DO, Abonofal A, Willett AF, Overman M, Smaglo B, Huey RW, Meric-Bernstam F, Varadhachary GR, Naing A. Efficacy of pembrolizumab in patients with advanced cancer of unknown primary (CUP): a phase 2 non-randomized clinical trial. J Immunother Cancer 10(5), 2022. e-Pub 2022. PMID: 35618285.
      35. Morris, VK, Overman, MJ, Lam, MC, Parseghian, C, Johnson, B, Dasari, NV, Raghav, KS, Kee, BK, Huey, RW, Wolff, RA, Shen, JY, Li, J, Zorrilla, I, Tzeng, CD, Tran Cao, HS, Chun, YS, Newhook, TE, Vauthey, JN, Duose, D, Luthra, R, Haymaker, CL, Kopetz, S. Bintrafusp Alfa, an Anti-PD-L1:TGFβ Trap Fusion Protein, in Patients with ctDNA-positive, Liver-limited Metastatic Colorectal Cancer. Cancer Research Communications 2(9):979-986, 2022. e-Pub 2022. PMID: 36382087.
      36. Huey RW, George GC, Phillips P, White R, Fu S, Janku F, Karp DD, Naing A, Piha-Paul S, Subbiah V, Tsimberidou AM, Pant S, Yap TA, Rodon J, Meric-Bernstam F, Shih YT, Hong DS. Patient-Reported Out-of-Pocket Costs and Financial Toxicity During Early-Phase Oncology Clinical Trials. Oncologist 26(7):588-596, 2021. e-Pub 2021. PMID: 33783054.
      37. Raghav K, Hwang H, Jácome AA, Bhang E, Willett A, Huey RW, Dhillon NP, Modha J, Smaglo B, Matamoros A, Estrella JS, Jao J, Overman MJ, Wang X, Greco FA, Loree JM, Varadhachary GR. Development and Validation of a Novel Nomogram for Individualized Prediction of Survival in Cancer of Unknown Primary. Clinical Cancer Research 27(12):3414-3421, 2021. e-Pub 2021. PMID: 33858857.
      38. Allen CJ, Eska JS, Thaker NG, Feeley TW, Kaplan RS, Huey RW, Tzeng CD, Lee JE, Frank SJ, Aloia TA, Gottumukkala V, Katz MHG. Developing a Value Framework: Utilizing Administrative Data to Assess an Enhanced Care Initiative. Journal of Surgical Research 262:115-120, 2021. e-Pub 2021. PMID: 33561722.
      39. Huey RW, Smaglo BG, Estrella JS, Matamoros A, Overman MJ, Varadhachary GR, Raghav KPS. Cancer of Unknown Primary Presenting as Bone-Predominant or Lymph Node-Only Disease: A Clinicopathologic Portrait. Oncologist 26(4):e650-e657, 2021. e-Pub 2021. PMID: 33524217.
      40. Middleton, LP, Huey, RW, Medeiros, LJ, Miranda, R. Follicular dendritic cell sarcoma in the differential diagnosis of GATA3 positive tumors. Human Pathology: Case Reports 23, 2021. e-Pub 2021.
      41. Augustyn A, Reed VI, Ahmad N, Bhutani MS, Bloom ES, Bowers JR, Chronowski GM, Das P, Holliday EB, Delclos ME, Huey RW, Koay EJ, Lee SS, Nelson CL, Taniguchi CM, Koong AC, Chun SG. Implementation of a stereotactic body radiotherapy program for unresectable pancreatic cancer in an integrated community academic radiation oncology satellite network. Clinical Translational Radiation Oncology 27:147-151, 2021. e-Pub 2021. PMID: 33665384.
      42. Allen CJ, Thaker NG, Prakash L, Kruse BC, Feeley TW, Kaplan RS, Huey R, Frank SJ, Aloia TA, Gottumukkala V, Katz MHG. Communicating Value: Use of a Novel Framework in the Assessment of an Enhanced Recovery Initiative. Ann Surg 273(1):e7-e9, 2021. e-Pub 2021. PMID: 32568750.
      43. Huey RW, Makawita S, Xiao L, Matamoros A, Estrella JS, Overman MJ, Varadhachary GR, Raghav K. Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait. BMC Cancer 19(1):965, 2019. e-Pub 2019. PMID: 31623602.
      44. Teague TK, Tan C, Marino JH, Davis BK, Taylor AA, Huey RW, Van De Wiele CJ. CD28 expression redefines thymocyte development during the pre-T to DP transition. Int Immunol 22(5):387-97, 2010. e-Pub 2010. PMID: 20203098.

      Review Articles

      1. Akula, M, Huey, RW, Hong, AS. Dissonance in the Sole Quality Measure for Outpatient Chemotherapy, OP-35. JCO Clinical Cancer Informatics 9, 2025. e-Pub 2025. PMID: 41428970.
      2. Huey RW, Pritchett JC, Vokinger KN, Swenson W, Haddad TC, Adelson K. Proposed Policy Changes to Cancer Care and Oncologic Drug Reimbursement: Exploring the Rationale and Anticipating the Consequences. Am Soc Clin Oncol Educ Book 45(3):e473822, 2025. e-Pub 2025. PMID: 40526882.
      3. Pellatt, AJ, Maddalena, G, Eluri, M, Parseghian, C, Aziz, KE, Alfaro, KD, Kell, R, Bent, AH, Huey, RW, Uppal, A, Konishi, T, Overman, MJ, Morelli, MP, Willis, JA, Shen, JY, Raghav, KS, Newhook, TE, Morris, VK, Dasari, NV, Kopetz, S. Redefining the prognostic significance of RAS and BRAF V600E mutations on disease free survival in patients with colorectal cancer in the era of ct-DNA defined minimal residual disease. Journal of Clinical Oncology 42:196, 2024. e-Pub 2024.
      4. Selig BP, Furr JR, Huey RW, Moran C, Alluri VN, Medders GR, Mumm CD, Hallford HG, Mulvihill JJ. Cancer chemotherapeutic agents as human teratogens. Birth Defects Res A Clin Mol Teratol 94(8):626-50, 2012. e-Pub 2012. PMID: 22851372.

      Editorials

      1. Lyu HG, Gordon WJ, Huey RW, Katz MHG. Leveraging the 21st Century Cures Act to Improve Cancer Care, Patient Engagement, and Data Collection. JCO Oncology Practice 18(12):788-790, 2022. PMID: 36219810.
      2. Huey RW, Hawk E, Offodile AC. Mind the Gap: Precision Oncology and Its Potential to Widen Disparities. J Oncol Pract 15(6):301-304, 2019. PMID: 31112478.

      Abstracts

      1. Raghav KP, Stephen B, Karp DD, Piha-Paul SA, Hong DS, Jain D, Chudy Onwugaje DO, Abonofal A, Willett AF, Overman M, Smaglo B, Huey RW, Meric-Bernstam F, Varadhachary GR, Naing A. Efficacy of pembrolizumab in patients with advanced cancer of unknown primary (CUP): a phase 2 non-randomized clinical trial. J Immunother Cancer 10(5), 2022. e-Pub 2022. PMID: 35618285.
      2. Raghav KP, Stephen B, Karp DD, Piha-Paul SA, Hong DS, Jain D, Chudy Onwugaje DO, Abonofal A, Willett AF, Overman M, Smaglo B, Huey RW, Meric-Bernstam F, Varadhachary GR, Naing A. Efficacy of pembrolizumab in patients with advanced cancer of unknown primary (CUP): a phase 2 non-randomized clinical trial. Journal for immunotherapy of cancer 10(5), 2022. e-Pub 2022. PMID: 35618285.
      3. Chun S, Augustyn A, Reed V, Ahmad N, Bhutani M, Bloom ES, Bowers J, Chronowski G, Das P, Holliday E, Delclos M, Huey R, Koay EJ, Lee S, Nelson C, Taniguchi C, Koong A. Implementation of a Stereotactic Body Radiotherapy Program for Unresectable Pancreatic Cancer in an Integrated Community Academic Radiation Oncology Satellite Network. Cureus Journal of Medical Science 14(2), 2022. e-Pub 2022.
      4. Morris VK, Parseghian CM, Escano M, Johnson B, Singh Raghav KP, Dasari A, Huey R, Overman MJ, Willis J, Lee MS, Wolff RA, Kee BK, YC Shen JP, Morelli MP, Tam A, Foo WC, Xiao L, Kopetz S. Phase I/II trial of encorafenib, cetuximab, and nivolumab in patients with microsatellite stable, BRAFV600E metastatic colorectal cancer 40(4_suppl):12-12, 2022. e-Pub 2022.
      5. Allam J, Ma L, Zhao J, Estrella J, Higbie V, Willett A, Matamoros A, Lano E, Treuner K, Raghav K, Huey RW. Clinicopathological characteristics of cancer of unknown primary (CUP) with renal profile using gene expression profiling (GEP) based cancer classification. 2025 GU ASCO.
      6. Huey R, George G, Phillips P, White R, Fu S, Janku F, Karp DD, Naing A, Piha-Paul SA, Subbiah V, Tsimberidou AM, Pant S, Yap TA, Ahnert JR, Meric-Bernstam F, Shih YT, Hong DS. Out of pocket costs and financial toxicity experienced by patients in early phase clinical trials. 2019 ASCO Annual Meeting I.
      7. Huey R, Anand S, Rogers JE, Dasari A, Varadhachary GR, Gothwal A, Loree JM, Ellis LM, Overman MJ, Singh Raghav KP. Value appraisal of FDA approved cancer drugs over the past decade. ASCO Quality Care Symposium.
      8. Morris VK, Singh Raghav KP, Dasari A, Overman MJ, Kee BK, Johnson B, Parseghian CM, YC Shen JP, Huey R, Raymond VM, Duose DY, Luthra R, Hong DS, Janku F, Kopetz S. Utility of circulating tumor DNA in the clinical management of patients with BRAFV600E metastatic colorectal cancer. Colorectal Cancer.
      9. Piha-Paul S, Tsimberidou A, Janku F, Raghav K, Wolff R, Huey R, Peng P, Levin W, Ngo B, Wang H, Sun C, Ru Q, Wu F, Javle M. P-261 Phase I study of multiple kinase inhibitor, TT-00420, in advanced, refractory cholangiocarcinoma.
      10. Shah AT, Huey R, Dasari P, Willett A, Smaglo BG, Matamoros A, Overman MJ, Estrella J, Singh Raghav AKP. Cancer of unknown primary with gastrointestinal profiles: A distinct CUP subset. Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary.
      11. Shah AT, Huey R, Dasari P, Willett A, Smaglo BG, Matamoros A, Overman MJ, Estrella J, Singh Raghav KP. Cancer of unknown primary with gastrointestinal profiles: A favorable CUP subset. Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary.
      12. Johnson B, Yang D, Dada HI, Morris VK, Wang X, Dasari A, Singh Raghav KP, Kee BK, YC Shen JP, Huey R, Lee MS, Parseghian CM, Le P, Morelli MP, Willis J, Wolff RA, Drusbosky L, Overman MJ, Kopetz S. RAS co-mutation and early onset disease represent an aggressive phenotype of atypical (non-V600) BRAF mutant metastatic colorectal cancer. Gastrointestinal Cancer—Colorectal and Anal.
      13. Parseghian CM, Sanchez EV, Sun R, Eluri M, Morris VK, Johnson B, Morelli MP, Overman MJ, Willis J, Huey R, Singh Raghav KP, Dasari A, Kee BK, Wolff RA, YC Shen JP, Kopetz S. Phase 2 study of anti-EGFR rechallenge therapy with panitumumab with or without trametinib in advanced colorectal cancer. Gastrointestinal Cancer—Colorectal and Anal.
      14. Johnson B, Haymaker C, Morris VK, Dasari A, Higbie VS, Shen JP, Parseghian C, Morelli MP, Huey R, Lee MS, Willis J, Raghav KP, Yuan Y, Zebala J, DePinho RA, Kopetz S, Overman M. Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer.
      15. Johnson :B, Pelicano H, Huey RW, Wolff RA, Wistuba II, Duose DY, Mallampati S, Luthra R, K Morris AV. HPV integration as a prognostic biomarker for metastatic anal cancer: A next-generation sequencing ctDNA-based approach. Gastrointestinal Cancer—Colorectal and Anal.
      16. Dasari A, Bent AH, Alfaro-Munoz K, Huey RW, Johnson B, Lee MS, Morelli MP, Morris VK, Overman MJ, Parseghian CM, Singh Raghav KP, Shen J, Willis J, Newhook TE, Uppal A, You Y, Konishi T, Chang GJ, Kopetz S, Wolff AR. Association of positive ctDNA-based minimal residual disease assays during surveillance and undiagnosed concomitant radiographic recurrences in colorectal cancer (CRC). Gastrointestinal Cancer—Colorectal and Anal.
      17. Rivers Z, Huey RW, Ben-Shachar R, Avadhani AN, Taxter TJ, Beauchamp KA, Hockenberry AJ, Nimeiri H, Allam J, Kalyan A, Singh Raghav KP, Lee MS. Molecular diagnostic classification for cancers of unknown primary (CUP): Post-testing diagnosis and treatment impact analysis from real-world claims data. Health Services Research and Quality Improvement.
      18. Smaglo BG, LeBleu VS, Lee J, Maitra A, Kalluri R, Rezvani K, Solis Soto LM, Hurd M, Kaur I, Mendt Vilchez MC, Kirtley ML, Shaftoe SL, Morelli MP, Overman MJ, Zhou D, Wolff RA, Tu J, Willis JA, Huey RW, Lee MS, Bhosale PR, Dworsky SW, Xu L, Pant S, Shpall EJ. Abstract C084: iExplore: A phase I study of mesenchymal stem cell derived exosomes with KrasG12D siRNA for metastatic pancreas cancer patients harboring the KrasG12D mutation.
      19. Andrew Jared Pellatt, Giulia Maddalena, Madhulika Eluri, Christine Megerdichian Parseghian, Kathryn Aziz, Kristin Alfaro, Robert J Kell, Alisha Heather Bent, Ryan W. Huey, Abhineet Uppal, Tsuyoshi Konishi, Michael J Overman, Maria Pia Morelli, Jason Willis, John Paul YC Shen, Kanwal Pratap Singh Raghav, Timothy E Newhook, Van K Morris, Arvind Dasari, Scott Kopetz. Redefining the prognostic significance of RAS and BRAF V600E mutations on disease free survival in patients with colorectal cancer in the era of ct-DNA defined minimal residual disease. 2024 ASCO Gastrointestinal Cancers Symposium.
      20. Pellatt AJ, Bent AH, Parseghian CM, Johnson B, Huey RW, Singh Raghav KP, Morris VK, Overman MJ, Morelli MP, Willis J, Le P, YC Shen JP, Lee MS, Alfaro K, Aziz K, Kell RJ, Sun R, Kopetz S, Dasari AA. A phase II trial of TAS-102 in patients with colorectal cancer with ctDNA-defined minimal residual disease post-adjuvant therapy. 2024 ASCO Gastrointestinal Cancers Symposium.
      21. Maddalena G, Pellatt AJ, Eluri M, Parseghian CM, Aziz K, Alfaro K, Kell RJ, Bent AH, Huey RW, Uppal A, Konishi T, Overman MJ, Morelli MP, Willis J, YC Shen JP, Singh Raghav KP, Newhook TE, Morris VK, Dasari A, Kopetz AS. INTERCEPT Program of circulating tumor DNA (ctDNA) testing for minimal residual disease (MRD) in colorectal cancer (CRC): Results from a prospective clinical cohort. 2024 ASCO Gastrointestinal Cancers Symposium.
      22. Higbie :V, Shah P, Bent AH, Dasari A, Huey RW, Johnson B, Kee BK, ALL … …S, J Overman AM. Natural history and patterns of progression for dMMR/MSI-H colorectal cancer treated with immune checkpoint blockade: A single center retrospective analysis. 2024 ASCO Gastrointestinal Cancers Symposium.
      23. Huey RW, Allam J, Ma L, Estrella J, Willett A, Beaty KA, Matamoros A, Lano EA, Fournier KF, Treuner K, Singh Raghav KP, W Huey AR. Utility of gene expression–based cancer classification in diagnosis of malignant peritoneal mesothelioma (MPeM): Filling in the gaps in standard pathologic work-up for a rare cancer. 2024 ASCO Gastrointestinal Cancers Symposium.
      24. Allam J, Zhao J, Estrella JS, Hwang H, Higbie VS, Willett AF, Matamoros A, Lano E, Raghav K, Huey RW. Clinical Characterization and Outcomes of Patients with PAX8 Positive Cancer of Unknown Primary: a Distinct Immunophenotypic Subset. 2024 ESMO Asia.
      25. Huey RW, Estrella JS, Higbie VS, Le P, Bent A, Matamoros A, Lano E, Willett A, Nguyen V, Escano-Caballero M, Wilson K, Lin H, Raghav K. Phase II Trial of Sintilimab in Cancer of Unknown Primary. 2025 GI ASCO.

      Book Chapters

      1. Huey, RW, Raghav, KS. Treatment Refractory Metastatic Colorectal Cancer, 287-292, 2022.
      2. SiBrito SR, Huey RW. Cancer of Unknown Primary Site. In: The MD Anderson Surgical Oncology Manual. 7. Wolters Kluwer.
      3. Allen CJ, Chen A, Huey RW, Shih YT. Value-Based Oncology.
      4. Varadhachary GV, Raghav KP, Huey RW. Carcinoma of Unknown Primary.

      Letters to the Editor

      1. Yousef, M, Yousef, A, Hurd, MW, Balachandran Pillai, A, Chowdhury, S, Snyder, RA, Knafl, M, Lewis, RL, Roy, PM, Fanaeian, M, Albarouki, S, Castelnovo, LF, Peterson, J, Smaglo, BG, Wolff, RA, Pant, S, Willis, JA, Huey, RW, Overman, MJ, Tzeng, CW, Kim, M, Ikoma, N, Maxwell, JE, Katz, MH, Wang, H, Maitra, A, Koay, EJ, Ludmir, EB, Chen, A, Lopez, C, Ying, H, Shen, JY, Zhao, D. KRAS mutation detection by liquid biopsy for pancreatic ductal adenocarcinoma. Journal of Hematology and Oncology 18, 2025.
      2. Huey, RW, Raghav, KS. Site-specific or empirical chemotherapy for cancer of unknown primary. The lancet oncology 25: e529, 2024.
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