Samir M. Hanash, M.D., Ph.D.
Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences
Present Title & Affiliation
Primary Appointment
Director, Department of Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director, Department of Center for Global Cancer Early Detection, The University of Texas MD Anderson Cancer Center, Houston, TX
Distinguished Chair, Department of Evelyn & Sol Rubenstein Distinguished Chair for Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Clinical Cancer Prevention - Research, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Department of Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1976 | University of Michigan, Ann Arbor, MI, USA, PHD, Human Genetics |
| 1972 | American University of Beirut, Lebanon, USA, BS, Human Genetics |
| 1972 | American University of Beirut, Lebanon, USA, MD, Human Genetics |
Honors & Awards
| 2013 | Evelyn & Sol Rubenstein Distinguished Chair for Cancer Prevention, University of Texas MD Anderson Cancer Center |
| 2006 | Distinguished Service Award HUPO |
| 2002 | University of Michigan Innovator Award |
| 1997 | INSERM Scholar Award |
| 1996 | Curie Institute Rothschild Award |
Selected Publications
Peer-Reviewed Articles
- Liu X, Yue Z, Cao Y, Taylor L, Zhang Q, Choi SW, Hanash S, Ito S, Chen JY, Wu H, Paczesny S. Graft-Versus-Host Disease-Free Antitumoral Signature After Allogeneic Donor Lymphocyte Injection Identified by Proteomics and Systems Biology. JCO Precis Oncol 3, 2019. e-Pub 2019. PMID: 31406955.
- Hanash S. The Wide World of Molecular Profiling for Tumor Classification. Clin Chem 64(4):743-744, 2018. e-Pub 2017. PMID: 29097505.
- Rho JH, Ladd JJ, Li CI, Potter JD, Zhang Y, Shelley D, Shibata D, Coppola D, Yamada H, Toyoda H, Tada T, Kumada T, Brenner DE, Hanash SM, Lampe PD. Protein and glycomic plasma markers for early detection of adenoma and colon cancer. Gut 67(3):473-484, 2018. e-Pub 2016. PMID: 27821646.
- Ostrin EJ, Little DR, Gerner-Mauro KN, Sumner EA, Ríos-Corzo R, Ambrosio E, Holt SE, Forcioli-Conti N, Akiyama H, Hanash SM, Kimura S, Huang SXL, Chen J. Beta-Catenin maintains lung epithelial progenitors after lung specification. Development 145(5), 2018. e-Pub 2018. PMID: 29440304.
- Cohen JD, Li L, Wang Y, Thoburn C, Afsari B, Danilova L, Douville C, Javed AA, Wong F, Mattox A, Hruban RH, Wolfgang CL, Goggins MG, Dal Molin M, Wang TL, Roden R, Klein AP, Ptak J, Dobbyn L, Schaefer J, Silliman N, Popoli M, Vogelstein JT, Browne JD, Schoen RE, Brand RE, Tie J, Gibbs P, Wong HL, Mansfield AS, Jen J, Hanash SM, Falconi M, Allen PJ, Zhou S, Bettegowda C, Diaz LA, Tomasetti C, Kinzler KW, Vogelstein B, Lennon AM, Papadopoulos N. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 359(6378):926-930, 2018. e-Pub 2018. PMID: 29348365.
- Wang T, Fahrmann JF, Lee H, Li YJ, Tripathi SC, Yue C, Zhang C, Lifshitz V, Song J, Yuan Y, Somlo G, Jandial R, Ann D, Hanash S, Jove R, Yu H. JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance. Cell Metab 27(1):136-150.e5, 2018. e-Pub 2017. PMID: 29249690.
- Kodama M, Kodama T, Newberg JY, Katayama H, Kobayashi M, Hanash SM, Yoshihara K, Wei Z, Tien JC, Rangel R, Hashimoto K, Mabuchi S, Sawada K, Kimura T, Copeland NG, Jenkins NA. In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer. Proc Natl Acad Sci U S A 114(35):7301-7310. e-Pub 2017. PMID: 28811376.
- Celiktas M, Tanaka I, Chandra Tripathi S, Fahrmann JF, Aguilar-Bonavides C, Villalobos P, Delgado O, Dhillon D, Dennison JB, Ostrin EJ, Wang H, Behrens C, Do KA, Gazdar AF, Hanash SM, Taguchi A. Role of CPS1 in Cell Growth, Metabolism, and Prognosis in LKB1-Inactivated Lung Adenocarcinoma. J Natl Cancer Inst 109(3), 2017. e-Pub 2016. PMID: 28034896.
- Peters HL, Tripathi SC, Kerros C, Katayama H, Garber HR, St John LS, Federico L, Meraz IM, Roth JA, Sepesi B, Majidi M, Ruisaard K, Clise-Dwyer K, Roszik J, Gibbons DL, Heymach JV, Swisher SG, Bernatchez C, Alatrash G, Hanash SM, Molldrem JJ. Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells. Cancer Immunol Res 5(4):319-329. e-Pub 2017. PMID: 28254787.
- Allenson K, Castillo J, San Lucas FA, Scelo G, Kim DU, Bernard V, Davis G, Kumar T, Katz M, Overman MJ, Foretova L, Fabianova E, Holcatova I, Janout V, Meric-Bernstam F, Gascoyne P, Wistuba I, Varadhachary G, Brennan P, Hanash SM, Li D, Maitra A, Alvarez H. High Prevalence of Mutant KRAS in Circulating Exosome-derived DNA from Early Stage Pancreatic Cancer Patients. Ann Oncol 28(4):741-747. e-Pub 2017. PMID: 28104621.
- Chen Y, Guo H, Terajima M, Banerjee P, Liu X, Yu J, Momin AA, Katayama H, Hanash SM, Burns AR, Fields GB, Yamauchi M, Kurie JM. Lysyl Hydroxylase 2 Is Secreted By Tumor Cells and Can Modify Collagen in the Extracellular Space. J Biol Chem 291(50):25799-25808, 2016. e-Pub 2016. PMID: 27803159.
- Tsou P, Katayama H, Ostrin EJ, Hanash SM. The Emerging Role of B Cells in Tumor Immunity. Cancer Res 76(19):5597-5601. e-Pub 2016. PMID: 27634765.
- Li W, Liu L, Gomez A, Zhang J, Ramadan A, Zhang Q, Choi SW, Zhang P, Greenson JK, Liu C, Jiang D, Virts E, Kelich SL, Chu HW, Flynn R, Blazar BR, Hanenberg H, Hanash SM, Paczesny S. Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease. JCI Insight 1(6), 2016. PMID: 27195312.
- Wang OH, Azizian N, Guo M, Capello M, Deng D, Zang F, Fry J, Katz MH, Fleming JB, Lee JE, Wolff RA, Hanash SM, Wang H, Maitra A. Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer. PLoS One 11(3):e0152300, 2016. e-Pub 2016. PMID: 27023625.
- Zhang C, Suo J, Katayama H, Wei Y, Garcia-Manero G, Hanash SM. Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines. Clin Proteomics 13:14, 2016. e-Pub 2016. PMID: 27382363.
- Akil A, Zhang Q, Mumaw CL, Raiker N, Yu J, Velez de Mendizabal N, Haneline LS, Robertson KA, Skiles J, Diaz-Ricart M, Carreras E, Renbarger J, Hanash S, Bies RR, Paczesny S. Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant 21(10):1739-45, 2015. e-Pub 2015. PMID: 26172478.
- Katayama H, Boldt C, Ladd JJ, Johnson MM, Chao T, Capello M, Suo J, Mao J, Manson JE, Prentice R, Esteva F, Wang H, Disis ML, Hanash S. An autoimmune response signature associated with the development of triple negative breast cancer reflects disease pathogenesis. Cancer Res 75(16):3246-54, 2015. e-Pub 2015. PMID: 26088128.
- Capello M, Lee M, Wang H, Babel I, Katz MH, Fleming JB, Maitra A, Wang H, Tian W, Taguchi A, Hanash SM. Carboxylesterase 2 as a Determinant of Response to Irinotecan and Neoadjuvant FOLFIRINOX Therapy in Pancreatic Ductal Adenocarcinoma. J Natl Cancer Inst 107(8):1-9, 2015. e-Pub 2015. PMID: 26025324.
- Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash SM, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci 5(10):1-10, 2015. e-Pub 2015. PMID: 25774287.
- Miyamoto S, Taylor SL, Barupal DK, Taguchi A, Wohlgemuth G, Wikoff WR, Yoneda KY, Gandara DR, Hanash SM, Kim K, Fiehn O. Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry. Metabolites 5(2):192-210, 2015. e-Pub 2015. PMID: 25859693.
- Lu M, Huang B, Hanash SM, Onuchic JN, Ben-Jacob E. Modeling putative therapeutic implications of exosome exchange between tumor and immune cells. Proc Natl Acad Sci U S A 111(40):E4165-74, 2014. e-Pub 2014. PMID: 25246552.
- Taguchi A, Taylor AD, Rodriguez J, Celiktas M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, Hanash SM. A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets. Cancer Res 74(17):4694-4705, 2014. e-Pub 2014. PMID: 24970476.
- Peng G, Chun-Jen Lin C, Mo W, Dai H, Park YY, Kim SM, Peng Y, Mo Q, Siwko S, Hu R, Lee JS, Hennessy B, Hanash SM, Mills GB, Lin SY. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun 5(3361):1-11, 2014. PMID: 24553445.
- Hanash S, Schliekelman M. Proteomic profiling of the tumor microenvironment: recent insights and the search for biomarkers. Genome Med 6(2):12, 2014. e-Pub 2014. PMID: 24713112.
- Mao J, Ladd J, Gad E, Rastetter L, Johnson MM, Marzbani E, Childs JS, Lu H, Dang Y, Broussard E, Stanton SE, Hanash SM, Disis ML. Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer. J Transl Med 12(121):1-10, 2014. e-Pub 2014. PMID: 24886063.
- Sin DD, Tammemagi CM, Lam S, Barnett MJ, Duan X, Tam A, Auman H, Feng Z, Goodman GE, Hanash S, Taguchi A. Pro-Surfactant Protein B as a Biomarker for Lung Cancer Prediction. J Clin Oncol 31(36):4536-43, 2013. e-Pub 2013. PMID: 24248694.
- Tam KW, Zhang W, Soh J, Stastny V, Chen M, Sun H, Thu K, Rios JJ, Yang C, Marconett CN, Selamat SA, Laird-Offringa IA, Taguchi A, Hanash SM, Shames D, Ma X, Zhang MQ, Lam WL, Gazdar A. CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non-Small-Cell Lung Cancer. J Thorac Oncol 8(11):1378-88, 2013. PMID: 24077454.
- Taguchi A, Hanash S, Rundle A, McKeague IW, Tang D, Darakjy S, Gaziano JM, Sesso HD, Perera F. Circulating pro-surfactant protein B as a risk biomarker for lung cancer. Cancer Epidemiol Biomarkers Prev 22(10):1756-61, 2013. e-Pub 2013. PMID: 23897585.
- Wu SL, Taylor AD, Lu Q, Hanash SM, Im H, Snyder M, Hancock WS. Identification of potential glycan cancer markers with sialic acid attached to sialic acid and up-regulated fucosylated galactose structures in epidermal growth factor receptor secreted from A431 cell line. Mol Cell Proteomics 12(5):1239-49, 2013. e-Pub 2013. PMID: 23371026.
- LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A 110(1):93-8, 2013. e-Pub 2012. PMID: 23248318.
- Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. PLoS One 8(6):e67054, 2013. e-Pub 2013. PMID: 23785517.
- Zhang S, Mercado-Uribe I, Hanash SM, Liu J. iTRAQ-Based Proteomic Analysis of Polyploid Giant Cancer Cells and Budding Progeny Cells Reveals Several Distinct Pathways for Ovarian Cancer Development. PLoS One 8(11):e80120, 2013. e-Pub 2013. PMID: 24348907.
- Thome CH, Dos Santos GA, Ferreira GA, Scheucher PS, Izumi C, Leopoldino AM, Simão AM, Ciancaglini P, de Oliveira KT, Chin A, Hanash SM, Falcão RP, Rego EM, Greene LJ, Faça VM. Linker for Activation of T-cell Family Member2 (LAT2) a Lipid Raft Adaptor Protein for AKT Signaling, Is an Early Mediator of Alkylphospholipid Anti-leukemic Activity. Mol Cell Proteomics 11(12):1898-912, 2012. e-Pub 2012. PMID: 23001822.
- Li CI, Mirus JE, Zhang Y, Ramirez AB, Ladd JJ, Prentice RL, McIntosh MW, Hanash SM, Lampe PD. Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study. Breast Cancer Res Treat 135(2):611-8, 2012. e-Pub 2012. PMID: 22903690.
- Lu H, Ladd J, Feng Z, Wu M, Goodell V, Pitteri SJ, Li CI, Prentice R, Hanash SM, Disis ML. Evaluation of known oncoantibodies, HER2, p53, and cyclin B1, in prediagnostic breast cancer sera. Cancer Prev Res (Phila) 5(8):1036-43, 2012. e-Pub 2012. PMID: 22715141.
- Ladd JJ, Busald T, Johnson MM, Zhang Q, Pitteri SJ, Wang H, Brenner DE, Lampe PD, Kucherlapati R, Feng Z, Prentice RL, Hanash SM. Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. Cancer Prev Res (Phila) 5(4):655-64, 2012. e-Pub 2012. PMID: 22277732.
- Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 20(3):289-99, 2011. PMID: 21907921.
- Hanash SM. Progress in mining the human proteome for disease applications. OMICS 15(3):133-9, 2011. PMID: 21375461.
- Hanash SM. Why have protein biomarkers not reached the clinic?. Genome Med 3(10):66, 2011. e-Pub 2011. PMID: 22030259.
- Pitteri S, Hanash SM. A systems approach to the proteomic identification of novel cancer biomarkers. Dis Markers 28(4):233-9, 2010. PMID: 20534908.
- Taylor AD, Hancock WS, Hincapie M, Taniguchi N, Hanash SM. Towards an integrated proteomic and glycomic approach to finding cancer biomarkers. Genome Med 1(6):57, 2009. e-Pub 2009. PMID: 19519948.
Grant & Contract Support
| Title: | Pancreatic Cancer Action Network Early Detection Targeted Grant |
| Funding Source: | Pancreatic Action Network |
| Role: | Principal Investigator |
| Title: | A Clinical Validation Center for Early Detection of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Early Detection of Ovarian Cancer with Tumor Associated Proteins and Autoantibodies |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Principal Investigator |
| Title: | Bridging Pediatric and Adult Biomarkers for Graft Versus Host Disease |
| Funding Source: | NIH/HD Indiana University |
| Role: | Co-Principal Investigator |
| Title: | Blood-based markers for screening and early detection of colorectal neoplasia |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Principal Investigator |
| Title: | Molecular Characterization of Interval Breast Cancers (Komen) |
| Funding Source: | Komen |
| Role: | Co-Principal Investigator |
| Title: | Imaging and Molecular Correlates of Progression in Cystic Neoplasms of the Pancreas |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Incorporating Biomarkers to Improve Lung Cancer Risk Prediction |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordination and Data Management Center (CSCPDPC-CDMC) |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Risk Markers for Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Discover Novel Therapeutic Strategies for Peritoneal Metastasis from Gastric Adenocarcinoma |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-Principal Investigator |
| Title: | Development of Risk and Early Detection Biomarker for Small Cell Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Defining and treating targetable lesions in AYA acute lymphoblastic leukemia |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Blood biomarkers for lung cancer screening risk assessment, and early detection |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | BE GONE Trial: Beans to Enrich the Gut of Obese Colorectal Cancer Survivors |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Co-Investigator |
| Title: | Risk, Detection and Outcomes Programs; Cancer Prevention |
| Funding Source: | CCSG |
| Role: | Co-Leader |
| Title: | CCSG – Risk, Detection and Outcomes |
| Funding Source: | NIH/NCRR |
| Role: | Co-Leader |
| Title: | Novel Protein Risk Markers for Lung Cancer |
| Funding Source: | Columbia University |
| Role: | Co-Investigator |
| Title: | Cancer Prevention By Alpha-Enolase Vaccination |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Lipidomics-based biomarkers for risk of progression in early prostate cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Circulating Exosomes as Biomarkers for Lung Cancer Early Detection |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Longitudinal therapeutic monitoring of colorectal cancer patients using exosome-based liquid biopsies |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Defining the novel cancer testis antigen HSPA1L as immunotherapeutic target in AML |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Coffee and Caffeine Metabolites and Disease Progression in Men Enrolled on Active Surveillance for Prostate Cancer |
| Funding Source: | American Institute for Cancer Research (AICR) |
| Role: | Co-Investigator |
| Title: | Optimizing Personalized Screening and Diagnostic Decisions for Lung Cancer Based on Dynamic Risk Assessment and Life Expectancy |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Clinical Validation Center for Lung Cancer Early Detection |
| Funding Source: | NIH |
| Role: | Principal Investigator |
| Title: | Clinical Validation Center for Early Detection of Pancreatic Cancer |
| Funding Source: | NIH |
| Role: | Co-Investigator |
| Title: | Fred Hutchinson Breast Cancer Clinical Validation Center |
| Funding Source: | NIH |
| Role: | Co-Investigator |
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