Samuel A. Shelburne III, M.D., Ph.D.
Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Professor, Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor (Joint appointment), Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Deputy Chair, Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX
Member, Graduate Faculty, The University of Texas Graduate School of Biomedical Science at Houston, Houston, TX
Dual/Joint/Adjunct Appointment
SHP Affiliate Graduate Faculty Member, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX
Member, Graduate Faculty, The University of Texas Graduate School of Biomedical Science at Houston, Houston, TX
Education & Training
Degree-Granting Education
| 2011 | Baylor College of Medicine, Houston, Texas, US, Ph.D. in Clinical Investigation |
| 2005 | Baylor College of Medicine, Houston, Texas, US, M.S. in Clinical Investigation |
| 1998 | University of Texas Medical Branch, Galveston, Texas, US, MD |
| 1994 | Princeton University, Princeton, New Jersey, US, AB in History of Art |
Postgraduate Training
| 2002-2005 | Clinical Fellowship, Infectious Diseases, Baylor College of Medicine, Houston, Texas |
| 2001-2002 | Chief Resident, Baylor College of Medicine, Houston, Texas |
| 1998-2001 | Clinical Internship, Internal Medicine, Baylor College of Medicine, Houston, Texas |
| 1998-2001 | Clinical Residency, Internal Medicine, Baylor College of Medicine, Houston, Texas |
Licenses & Certifications
| 2004 | American Board of Internal Medicine, Infectious Diseases |
| 2002 | American Board of Internal Medicine |
| 2001 | Medical |
Experience & Service
Faculty Academic Appointments
Associate Professor, Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2018
Clinical Assistant Professor, Texas A&M Health Science Center of Medicine, College Station, TX, 2010 - 2019
Adjunct Assistant Professor, Baylor College of Medicine, Houston, TX, 2008 - 2021
Assistant Professor, Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2008 - 2012
Affiliate Member, Methodist Hospital Research Institute, Houston, TX, 2008 - 2019
Assistant Professor, Baylor College of Medicine, Houston, TX, 2005 - 2008
Chief Medical Resident, Baylor College of Medicine, Houston, TX, 2001 - 2002
Administrative Appointments/Responsibilities
Deputy Chair, Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - Present
Director, Genomic Infectious Diseases Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - Present
Other Professional Positions
Steering Committee, Antibiotic Resistance Leadership Group, Durham, NC, 2019 - 2026
Steering Committee, Gulf Coast Consortium on Antimicrobial Resistance, Houston, TX, 2016 - Present
Leader, Microbiome Working Group, MD Anderson Cancer Center, Houston, TX, 2015 - 2022
Organizer, MD Anderson Infectious Diseases Faculty Research Meeting, Houston, TX, 2011 - Present
Organizer, MD Anderson Infectious Diseases Journal Club, Houston, TX, 2010 - 2013
Interviewer, MD Anderson Infectious Diseases Fellowship, Houston, TX, 2008 - Present
Research Postdoctoral Fellow, James M. Musser Laboratory, The Methodist Hospital, Houston, TX, 2003 - 2005
Extramural Institutional Committee Activities
Member, Promotion and Tenure, The University of Texas MD Anderson Cancer Center, 2024 - 2026
Member, Infectious Diseases Leadership Group, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Faculty Diversity Panel, The University of Texas MD Anderson Cancer Center, 2021 - 2023
Member, Faculty Recruitment Panel, The University of Texas MD Anderson Cancer Center, 2021 - 2023
Chair, Immunocompromised Section - Antibiotic Resistance Leadership Group, NIAID, 2019 - 2025
Member, Department of Cardiology Search Committee, The University of Texas MD Anderson Cancer Center, 2019 - 2020
Director, Microbiome Core Facility, The University of Texas MD Anderson Cancer Center, 2018 - Present
Member, Clinical Research Advisory Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2020
Member, Special Emphasis Committee - Antibiotic Resistance Leadership Group, NIAID, 2017 - 2019
Member, Multidisciplinary Research Advisory Committee, The University of Texas MD Anderson Cancer Center, 2016 - Present
Member, INTEREST Review Committee, The University of Texas MD Anderson Cancer Center, 2015 - Present
Chair, Division of Internal Medicine Research Committee, The University of Texas MD Anderson Cancer Center, 2013 - 2015
Member, Physician Scientist Recruitment Panel, The University of Texas MD Anderson Cancer Center, 2013 - Present
Vice-Chair, Division of Internal Medicine Research Committee, The University of Texas MD Anderson Cancer Center, 2011 - 2013
Member, Basic Study Section Review Committee-Institutional Research Grants Program, The University of Texas MD Anderson Cancer Center, 2011 - 2013
Chair, Department of Infectious Diseases Basic Science Faculty Search Committee, The University of Texas MD Anderson Cancer Center, 2011 - Present
Member, Scientific Review Committee, The University of Texas MD Anderson Cancer Center, 2011 - 2021
Member, Division of Internal Medicine Research Committee, The University of Texas MD Anderson Cancer Center, 2010 - 2011
Editorial Activities
Editorial Board Member, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019 - Present
Member of Editorial Review Board, Antimicrobial Agents and Chemotherapy, 2015 - Present
Member of Editorial Review Board, Journal of Infection, 2006 - Present
Honors & Awards
| 2019 | Outstanding Clinical Research Mentor, MD Anderson School of Health Professions |
| 2018 | Cyrus Scholar Award for Outstanding Basic Research, Division of Internal Medicine, MD Anderson Cancer Center |
| 2015 | Fellow, Infectious Diseases Society of America |
| 2015 | Finalist, Robert M. Chamberlain Distinguished Mentor Award, MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center |
| 2014 - 2023 | R. Lee Clark Fellow, MD Anderson Cancer Center |
| 2013 | Teaching Faculty of the Year Infectious Disease Fellowship Program, Baylor College of Medicine |
| 2013 | Cyrus Scholar Award Winner, MD Anderson Cancer Center |
| 2011 | Basic Research Outstanding Poster Award, Division of Internal Medicine Research Symposium, MD Anderson Cancer Center |
| 2009 | Semi-Finalist, Cyrus Award, Division of Internal Medicine Research Retreat, MD Anderson Cancer Center |
| 2007 - 2011 | Travel Award, American Society for Clinical Investigation/American of Physicians Joint Meeting in Chicago |
| 2005 | Outstanding Research Award, Baylor College of Medicine |
| 2000 - 2002 | Baylor Graduate Medical Education Resident Teaching Award, Baylor College of Medicine |
| 1999 - 2000 | Outstanding Resident Educator, Baylor College of Medicine |
| 1999 - 2000 | Outstanding Clinical Research Award, Baylor College of Medicine |
| 1996 | Elected to AΦA as Junior Year Medical Student, University of Texas Medical Branch |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Etiology and management of streptococcal infections in cancer patients. Invited. Grand Rounds. Houston, Texas, US.
- 2025. Antimicrobial Resistance in Cancer Patients: The Canary in the Coal Mine?. Invited. Grand Rounds. Galveston, Texas, US.
- 2023. The Ever Evolving Role of Genomics in Infectious Diseases Research. Invited. Texas Children's Hospital Infectious Diseases Research Symposium. Houston, Texas, US.
- 2020. Genomic Infectious Diseases: Yesterday, Today, and Tomorrow. Invited. Grand Rounds. Houston, Texas, US.
- 2020. Impact of Large Scale DNA Sequencing on Infectious Diseases in the 21st century. Invited. Keck Seminar Series. Houston, Texas, US.
- 2019. Functional Insights into Virulence Factor Regulation in Group A Streptococcus. Invited. Molecular Biology of Infectious Diseases. Houston, Texas, US.
- 2018. Genomic Approaches to Infectious Diseases. Invited. Daniel Musher Visiting Professor Lecture. Houston, TX, US.
- 2016. How Large Scale Whole Genome Analyses of Bacteria are Changing our Understanding of Human Infectious Diseases. Invited. Grand Rounds. Houston, Texas, US.
- 2016. Infectious Diseases and Personalized Medicine: A Return to Our Roots. Invited. Molecular Biology of Infectious Diseases Research Retreat. Houston, Texas, US.
- 2015. HPV-microbiome-epithelial cell interactions and the implications for cancer. Invited. Grand Rounds. Houston, Texas, US.
- 2014. Analysis of Fluoroquinolone Resistance In Viridans Group Streptococci Causing Invasive Disease in Cancer Patients. Invited. Grand Rounds. Houston, Texas, US.
- 2013. Using the Microbiome to Predict Infections in Immunocompromised Patients. Invited. MD Anderson Grand Rounds. Houston, Texas, US.
- 2013. Towards a Molecular Understanding of Viridans Group Streptococcal Pathogenesis. Invited. Department of Pathology Grand Rounds. Houston, Texas, US.
- 2013. Documentation of an Invasive Phenotype of Group A Streptococcus Arising During Human Infection Using Whole Genome Sequencing of Multiple Clinical Isolates From the Same Patient. Invited. Grand Rounds. Houston, Texas, US.
- 2013. Identification and Characterization of Streptococcus mitis Strains Causing Severe Clinical Disease in Cancer Patients. Conference. Internal Medicine Research Retreat. Houston, Texas, US.
- 2013. Genomics 101. Invited. MD Anderson Employee Education. Houston, Texas, US.
- 2013. Towards a Molecular Understanding of Streptococcal Pathogenesis. Invited. Grand Rounds. Houston, Texas, US.
- 2012. Towards a Molecular Understanding of Streptococcal Pathogenesis. Invited. Molecular Biology of Infectious Diseases. Houston, Texas, US.
- 2012. What’s New with the Streptococci. Invited. Grand Rounds. Houston, Texas, US.
- 2012. Genomics 101. Invited. MD Anderson Employee Education. Houston, Texas, US.
- 2011. Using Single-Nucleotide Polymorphisms to Study Streptococcal Pathogenesis. Invited. Molecular Biology of Infectious Diseases. Houston, Texas, US.
- 2011. New Insights into Streptococcal Pathogenes. Invited. McLaughlin Colloquium. Galveston, Texas, US.
- 2011. New Insights into the Molecular Basis of Streptococcal Pathogenesis. Invited. Grand Rounds. Houston, Texas, US.
- 2011. Update on Streptococcal Epidemiology and Pathogenesis. Invited. Grand Rounds. Houston, Texas, US.
- 2009. The Role of Biochemistry in Understanding Bacterial Pathogenesis. Invited. Grand Rounds. Houston, Texas, US.
- 2008. Novel avenues of investigation of group A Streptococcus pathogenesis. Invited. Texas A&M Infection and Immunity Symposium. Houston, Texas, US.
- 2008. Link between central metabolism and virulence in group A Streptococcus. Invited. Houston, Texas, US.
- 2008. Antimicrobial resistance in staphylococci and streptococci: what's happened and where are we going. Invited. Grand Rounds. Houston, Texas, US.
- 2008. Links between carbohydrate utilization and virulence in group A Streptococcus. Invited. Grand Rounds. Houston, Texas, US.
- 2008. Methicillin-resistant Staphylococcus aureus: not just for hospitals. Invited. Grand Rounds. Houston, Texas, US.
- 2007. Recent Developments in the Epidemiology and Treatment of Gram-Positive Pathogens. Invited. Grand Rounds. Galveston, Texas, US.
- 2006. Group A Streptococcus Nutrient Utilization in vivo. Invited. Grand Rounds. Houston, Texas, US.
- 2006. The role of polysaccharide utilization in group A Stretococcus pharyngitis. Invited. Houston, Texas, US.
- 2005. Novel insights into Group A Streptococcus host-pathogen interaction in the human oropharynx. Invited. Grand Rounds. Houston, Texas, US.
- 2005. Analysis of Group A Streptococcus-Saliva Interaction. Invited. Molecular Biology of Infectious Diseases Data Club. Houston, Texas, US.
- 2005. Group A Streptococcus host-pathogen interaction in the human oropharynx. Invited. Grand Rounds. Houston, Texas, US.
- 2005. New Insights into Group A Streptococcus Pharyngitis. Invited. Grand Rounds. Houston, Texas, US.
- 2005. Group A Streptococcus-saliva interaction. Invited. Clinical Scientist Training Program Annual Retreat. Houston, Texas, US.
Regional Presentations
- 2026. Antimicrobial Resistance in the Immunocompromised Patient in Texas: What Do We Know and How Do We Know It?. Invited. Texas Infectious Diseases Society. Bastrop, TX, US.
- 2018. Genomic Approaches to Infectious Diseases Research. Invited. Microbiology Seminar. Dallas, Texas, US.
- 2018. Identification of Clinically Significant Antimicrobial Resistance Genes in the Commensal Microbiota. Invited. Antimicrobial Resistance & Gut Health Symposium. Houston, Texas, US.
- 2017. Antimicrobial Resistance and Cancer: A Perfect Storm. Invited. Antimicrobial Resistance Symposium. Houston, Texas, US.
National Presentations
- 2024. Use of Oxford Nanopore Sequencing to Evaluate Potential Transmission of Hospital Infections. Invited. Oxford Nanopore Technologies Meeting. Boston, MA, US.
- 2023. Genomic Approaches to Infectious Diseases Research. Invited. Emory University Infectious Diseases Seminar. Atlanta, Georgia, US.
- 2022. Antimicrobial Resistance in the Immunocompromised Patient. Invited. Antibiotic Resistance Leadership Group. Bethesda, Maryland, US.
- 2020. Antibiotic Trails in Immunocompromised Patients. Invited. Antibiotic Resistance Leadership Gropu. Bethesda, Maryland, US.
- 2018. Insights into Infectious Diseases Generated by Genomic Approaches: Lessons from the Front Line. Invited. Association of Clinical Scientists Annual Meeting. Houston, TX, US.
- 2017. The Impact of the Microbiome on Infectious Outcomes in Patients with Hematologic Malignancy. Conference. The Impact of the Microbiome on Infectious Outcomes in Patients with Hematologic Malignancy. Houston, TX, US.
- 2017. Clinical Impact of Bacterial Whole Genome Sequencing: Lessons from the Front Line. Conference. Whole Genome Sequencing and Infectious Diseases Conference. Austin, TX, US.
- 2016. The Mycobiome in Treated Cancer Patients. Invited. International Conference on Antimicrobial Agents and Chemotherapy. Boston, MA, US.
- 2015. Viridans group streptococci: Can the Clinical Microbiology Laboratory help?. Invited. Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, California, US.
- 2014. Integration of host genomics into infectious risk in AML patients: challenges and opportunities. Conference. Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, District of Columbia, US.
- 2013. Personalized Cancer Therapy: A Primer on Molecular Genetics. Invited. Society of Hematologic Oncology. Houston, Texas, US.
- 2005. Role of Maltodextrin Binding in Group A Streptococcus Pharyngitis. Conference. Role of Maltodextrin Binding in Group A Streptococcus Pharyngitis. Hamilton, MT, US.
- 2005. Role of Maltodextrin Binding in Group A Streptococcus Pharyngitis. Conference. Role of Maltodextrin Binding in Group A Streptococcus Pharyngitis. Toronto, US.
- 2003. Proposal on trial for prevention of immune reconstitution inflammatory syndrome. Conference. Community sponsored clinical trials. Miami, FL, US.
International Presentations
- 2026. Global Burden of Antimicrobial Resistance in the Immunocompromised Patients: What Do We Know and What Might be the Causes?. Invited. International Immunocompromised Host Society. Houston, US.
- 2026. New Insights into How the CovRS System Impacts GAS Pathophysiology. Invited. Global Virtual Streptococcus Research Symposium.
- 2022. Challenging Antimicrobial Resistance Cases in Immunocompromised Patients. Invited. Universidad El Bosque. Bogotá D.C, CO.
- 2016. The Next-Generation of Group A Streptococcal Research: More than Next-Generation Sequencing. Invited. Keynote Speaker. Toronto Invasive Bacterial Diseases Network-Education Day. Toronto, CA.
- 2008. CcpA Directly Links Virulence and Carbohydrate Utilization in Group A Streptococcus. Conference. Lancefield International Symposium on Streptococci and Streptoccocal Diseases. Athens, GR.
Formal Peers
- 2026. Infections in Cancer Patients. Houston, Texas, US.
- 2025. Infections in Cancer Patients. Houston, Texas, US.
- 2024. Infections in Cancer Patients. Houston, Texas, US.
- 2023. Infections in Cancer Patients. Houston, Texas, US.
- 2022. Infections in Cancer Patients. Houston, Texas, US.
- 2021. Infections in Cancer Patients. Houston, Texas, US.
- 2020. Infections in Cancer Patients. Houston, Texas, US.
- 2019. Infections in Cancer Patients. Houston, Texas, US.
- 2018. Infections in Cancer Patients. Houston, Texas, US.
- 2017. Infections in Cancer Patients. Houston, Texas, US.
- 2007. Skin and soft tissue infections. Visiting. Houston, Texas, US.
- 2006. HIV for the Primary Care Physician. Visiting. Houston, Texas, US.
- 2006. Chronic Fungal sinusitis. Invited. Houston, Texas, US.
Grant & Contract Support
| Date: | 2026 - 2028 |
| Title: | Role of the SpoV Region in Group A Streptococcal Toxin Regulation |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI204229-01 |
| Date: | 2026 - 2028 |
| Title: | Use of small molecule inhibitors of CovS phosphatase activity to study the pathophysiology of group A Streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI196203-01A1 |
| Date: | 2025 - 2030 |
| Title: | 1K01AI192504-01 |
| Funding Source: | NIAID |
| Role: | Mentor |
| ID: | Multidisciplinary Approach to Elucidating Factors Driving Recurrent Enterobacterales Bacteremia |
| Date: | 2025 - 2027 |
| Title: | Reducing Nosocomial Outbreak Detection Time Through Long-Read Sequencing for Rapid Genomic Characterization of High-Risk Pathogens |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI187878-01A1 |
| Date: | 2025 - 2027 |
| Title: | Assessment and targeting of CovS phosphatase activity in the pathogenesis of group A Streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI185009-01A1 |
| Date: | 2025 - 2027 |
| Title: | Use of small molecule inhibitors of CovS phosphatase activity to study the pathophysiology of group A Streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI196203-01 |
| Date: | 2024 - 2026 |
| Title: | Delineation of mechanisms underlying response regulator activation in group A Streptococcus |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | 1R21AI177931-01A1 |
| Date: | 2024 - 2029 |
| Title: | Multidisciplinary Approach to Elucidating Factors Driving Recurrent Enterobacterales Bacteremia |
| Funding Source: | NIAID |
| Role: | Mentor |
| ID: | 1K01AI192504 |
| Date: | 2024 - 2026 |
| Title: | Assessment and targeting of CovS phosphatase activity in the pathogenesis of group A Streptococcus |
| Funding Source: | https://ror.org/043z4tv69 |
| Role: | PI |
| ID: | 1R21AI185009-01 |
| Date: | 2023 - 2028 |
| Title: | Role of response regulator phosphorylation in group A streptococcal pathogenesis |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 2R01AI125292-06A1 |
| Date: | 2023 - 2025 |
| Title: | Delineation of mechanisms underlying response regulator activation in group A Streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI177931-01 |
| Date: | 2022 - 2024 |
| Title: | Identifying mechanisms by which two critical global regulators coordinate metabolism and virulence in the group A Streptococcus |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R21AI168665-01 |
| Date: | 2022 - 2027 |
| Title: | Role of response regulator phosphorylation in group A streptococcal pathogenesis |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 2R01AI125292-06 |
| Date: | 2022 - 2024 |
| Title: | Identifying mechanisms by which two critical global regulators coordinate metabolism and virulence in the group A Streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI168665-01A1 |
| Date: | 2021 - 2024 |
| Title: | Impact of regulatory cross-talk on the pathophysiology of emergent acapsular group A streptococcus |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | 1R21AI156202-01A1 |
| Date: | 2021 - 2023 |
| Title: | Role of β-lactamase encoding gene amplification in the development of non-carbapenemase producing, carbapenem-resistant Enterobacteriaceae |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator-MDACC |
| ID: | 1R21AI151536-01A1 |
| Date: | 2021 - 2024 |
| Title: | Defining novel mechanisms of clonal emergence in Group A Streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | R21AI159059 |
| Date: | 2020 - 2026 |
| Title: | Dynamics of colonization and infection by multidrug-resistant pathogens in immunocompromised and critically ill patients (DYNAMITE) – Project 2 |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator-MDACC |
| ID: | 1P01AI152999-02 |
| Date: | 2020 - 2026 |
| Title: | Dynamics of colonization and infection by multidrug-resistant pathogens in immunocompromised and critically ill patients (DYNAMITE) – CORE - FUSE |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator-MDACC |
| ID: | 1P01AI152999-02 |
| Date: | 2020 - 2022 |
| Title: | Role of β-lactamase encoding gene amplification in the development of non-carbapenemase producing, carbapenem-resistant Enterobacteriaceae |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI151536-01 |
| Date: | 2020 - 2022 |
| Title: | Impact of regulatory cross-talk on the pathophysiology of emergent acapsular group A streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI156202-01 |
| Date: | 2019 - 2021 |
| Title: | Antibacterial Resistance Leadership Group (ARLG) |
| Funding Source: | NIH/NIAID |
| Role: | Scientific Expert |
| ID: | 5UM1AI104681 |
| Date: | 2019 - 2024 |
| Title: | Novel analysis of association between microbiome and treatment infection in AML |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | R01AI143886 |
| Date: | 2019 - 2024 |
| Title: | Dissection of regulatory system mutations impacting acapsular group A streptococcal virulence |
| Funding Source: | NIH/NIAID |
| Role: | PI |
| ID: | R01AI144165 |
| Date: | 2019 - 2023 |
| Title: | Identifying Risk Factors for Antibiotic Resistance via Integration of Epidemiology and Metagenomics |
| Funding Source: | NIH/NIAID |
| Role: | Mentor |
| ID: | 1K01AI143881 |
| Date: | 2019 - 2024 |
| Title: | Dissection of regulatory system mutations impacting acapsular group A streptococcal virulence |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R01AI144165-01 |
| Date: | 2019 - 2023 |
| Title: | Dissection of regulatory system mutations impacting acapsular group A streptococcal virulence |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R01AI144165-01A1 |
| Date: | 2018 - 2020 |
| Title: | Composition and temporal changes of the oral microbiome in head and neck cancer patients at high risk for oral mucositis |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | DE026837 |
| Date: | 2018 - 2020 |
| Title: | Detection and Kinetics of clinically relevant antibiotic resistance in the commensal microbiota |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | R21 AI33301 |
| Date: | 2018 - 2020 |
| Title: | Impact of a novel emm-enn gene fusion event on epidemic behavior of group A streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI142126-01 |
| Date: | 2017 - 2019 |
| Title: | Development of novel methodology to associate microbiome data with clinical outcomes |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 1R03CA216030-01A1 |
| Date: | 2017 - 2019 |
| Title: | Novel mechanisms of emergence of hypervirulent group A Streptococcus |
| Funding Source: | NIAID |
| Role: | PI |
| ID: | 1R21AI132920-01 |
| Date: | 2016 - 2021 |
| Title: | Role of response regulator phosphorylation in group A streptococcal pathogenesis |
| Funding Source: | NIH/NIAID |
| Role: | Investigator |
| ID: | R01AI125292 |
| Date: | 2015 - 2017 |
| Title: | Role of the Gastrointestinal Microbiome in the Care of the Cancer Patient, Multi-disciplinary research project |
| Funding Source: | MD Anderson Cancer Center |
| Role: | Co-I |
| Date: | 2014 - 2017 |
| Title: | R.Lee Clark Fellow |
| Funding Source: | MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2013 - 2017 |
| Title: | Integrated program in toxicity genomics in patients treated for acute Myelogenous Leukemia/Myelodysplastic Syndrome |
| Funding Source: | MD Anderson Cancer Center |
| Role: | Co-I |
| Date: | 2011 - 2016 |
| Title: | Contribution of catabolite control protein A to group A streptococcal virulence |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator-MDACC |
| ID: | R01 AI089891 |
| Date: | 2011 - Present |
| Title: | Optimizing management of enterococcal bacteriuria |
| Funding Source: | Veterans Administration |
| Role: | Co-I |
| Date: | 2010 - 2012 |
| Title: | Structure-function analysis of the streptococcal control of virulence regulator |
| Funding Source: | Institutional Research Grant |
| Role: | Principal Investigator-MDACC |
| Date: | 2009 - 2011 |
| Title: | The structural and functional basis for the contribution of catabolite protein A to group A streptococcal pathogenesis |
| Funding Source: | American Heart Association |
| Role: | Principal Investigator-MDACC |
| Date: | 2006 - 2010 |
| Title: | Analysis of Group A Streptococcus-saliva interaction |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator-MDACC |
| ID: | K08-AI064564 |
| Date: | 2005 - 2009 |
| Title: | The Role of polysaccharide utilization in group A Streptococcus host-pathogen interaction |
| Funding Source: | American Heart Association |
| Role: | Principal Investigator-MDACC |
| ID: | 0765115Y |
| Date: | 2005 - 2006 |
| Title: | Analysis of Group A Streptococcus-saliva interaction. Mentored Clinical Investigator Career Development Award |
| Funding Source: | NIH/NIDA |
| Role: | Principal Investigator-MDACC |
| ID: | K08 AI 064564 |
| Date: | 2003 - 2005 |
| Title: | Institutional Research Training Grant |
| Funding Source: | NIH/NIAID |
| Role: | Trainee |
| Date: | 2002 - 2003 |
| Title: | Incidence and risk factors for immune reconstitution syndrome in HIV-infected patients |
| Funding Source: | Bristol-Meyers Squibb (BMS) HIV Fellow Grant |
| Role: | Principle Investigator-BCM |
Selected Publications
Peer-Reviewed Articles
- Morrison GA, Vega LA, Sanson Iglesias M, Holly K Jr, McDonald WH, Horstmann N, Shelburne SA, Gaddy JA, Flores AR. SpxA1 and SpxA2 function as a stoichiometry-dependent regulatory rheostat governing virulence gene expression in group A Streptococcus. mBio:e0165026, 2026. e-Pub 2026. PMID: 42549902.
- Mackow NA, Shao W, Ge L, Komarow L, Jiang J, Boutzoukas A, Chen L, Garcia-Diaz J, Herc ES, Doi Y, Arias CA, Albin O, Saade E, Miller LG, Jacob JT, Satlin MJ, Krsak M, Huskins WC, Dhar S, Shelburne SA, Hill C, Alby K, Sadler JM, Hill BM, Greenwood-Quaintance KE, Schmidt-Malan SM, Patel R, Fowler VG, Tamma PD, Kreiswirth BN, van Duin D. Escherichia coli ST131 Drives Carbapenem Use for E. coli Bloodstream Infections. Clin Infect Dis 83(1):e27-e37, 2026. e-Pub 2026. PMID: 41795867.
- Shropshire, W, Borjan, J, Fonseca, IY, Pham, K, Guerrero, M, Liboro, K, Young, A, Chung, JK, Wu, CT, Manzanares, A, Bhatti, MM, Vuong, NN, Handley, GH, Spallone, A, Chemaly, RF, Khan, A, Shelburne, S. Clinical and genomic determinants associated with emergent ceftazidime–avibactam plus aztreonam non-susceptibility in ceftazidime-avibactam resistant Escherichia coli. Antimicrobial agents and chemotherapy 70(5), 2026. e-Pub 2026. PMID: 41870042.
- Stabler, AV, Shropshire, W, Young, A, Feng, C, Hwang, H, Shelburne, S, Vuong, NN, Borjan, J. Cumulative cefepime exposure in cancer patients is associated with an increased risk of ertapenem non-susceptible, meropenem susceptible Enterobacterales bacteremia. Microbiology spectrum 14(4):1-14, 2026. e-Pub 2026. PMID: 41817192.
- Deng, Y, Wang, M, Chopra, C, Shelburne, S, Miller, WR, Kirienko, NV. R pyocin sensitivity of Pseudomonas aeruginosa clinical isolates from different disease types. Journal of medical microbiology 75(6), 2026. e-Pub 2026. PMID: 42329126.
- Franklin, S, Sahasrabhojane, P, Hayase, T, Hayase, E, Chang, C, Senapati, J, Desikan, SP, Kadia, TM, Lorenzi, PL, Jenq, RR, Shelburne, S, Galloway-Pena, J. Short-chain fatty acid-producing microbes differentiate differentiate differentiate differentiate non-infectious and infectious neutropenic fever in leukemia. mSystems 11(4):1-18, 2026. e-Pub 2026. PMID: 41914747.
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- Shelburne SA, Song X, Bremer J, Seo S, Rodriguez S, Selvaraj Anand S, Dinh AQ, Bhatti MM, Konovalova A, Arias CA, Kalia A, Shamoo Y, Shelburne SA. Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure. J Infect Dis, 2024. e-Pub 2024. PMID: 39602497.
- Gomez AA, Kjerfve C, Choi M, Liu W, Churion K, Thomas S, Rohde H, Shelburne SA, Skare JT, Hook M, Arora S. Staphylococcus epidermidis ST2 strains associated with bloodstream infections contain a unique mobile genetic element encoding a plasmin inhibitor. mBio, 2024. e-Pub 2024. PMID: 39560391.
- Hayase E, Hayase T, Mukherjee A, Stinson SC, Jamal MA, Ortega MR, Sanchez CA, Ahmed SS, Karmouch JL, Chang CC, Flores II, McDaniel LK, Brown AN, El-Himri RK, Chapa VA, Tan L, Tran BQ, Xiao Y, Fan C, Pham D, Halsey TM, Jin Y, Tsai WB, Prasad R, Glover IK, Enkhbayar A, Mohammed A, Schmiester M, King KY, Britton RA, Reddy P, Wong MC, Ajami NJ, Wargo JA, Shelburne SA, Okhuysen PC, Liu C, Fowler SW, Conner ME, Katsamakis Z, Smith N, Burgos da Silva M, Ponce DM, Peled JU, van den Brink MRM, Peterson CB, Rondon G, Molldrem JJ, Champlin RE, Shpall EJ, Lorenzi PL, Mehta RS, Martens EC, Alousi AM, Jenq RR. Bacteroides ovatus alleviates dysbiotic microbiota-induced graft-versus-host disease. Cell Host Microbe, 2024. e-Pub 2024. PMID: 39214085.
- El Haddad L, Angelidakis G, Zhai Y, Yaghi L, Arias CA, Shelburne SA, Jeong KC, Chemaly RF. Persistence of Daptomycin-Resistant and Vancomycin-Resistant Enterococci in Hospitalized Patients with Underlying Malignancies: A 7-Year Follow-Up Study. Microorganisms, 2024. e-Pub 2024. PMID: 39203518.
- Egge SL, Rizvi SA, Simar SR, Alcalde M, Martinez JRW, Hanson BM, Dinh AQ, Baptista RP, Tran TT, Shelburne SA, Munita JM, Arias CA, Hakki M, Miller WR. Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin. Antimicrob Agents Chemother, 2024. e-Pub 2024. PMID: 38995033.
- Shelburne SA, Vega LA, Mukherjee P, DebRoy S, Flores AR, Shelburne SA. Emergent emm4 group A Streptococcus evidences a survival strategy during interaction with immune effector cells. Infect Immun, 2024. e-Pub 2024. PMID: 38888310.
- Axell-House, DB, Ashley, PA, Egge, SL, Tran, TT, Pedroza, C, Zhang, M, Dinh, AQ, Simar, SR, Sahasrabhojane, P, Miller, WR, Shelburne, S, Hanson, B, Arias, CA. Clinical Features and Genomic Epidemiology of Bloodstream Infections due to Enterococcal Species Other Than Enterococcus faecalis or E. faecium in Patients With Cancer. Open Forum Infectious Diseases 11(6), 2024. e-Pub 2024. PMID: 38835498.
- Gerges, B, Rosenblatt, J, Truong, YL, Jiang, Y, Shelburne, S, Chaftari, AP, Hachem, RY, Raad, II. In vitro activity of cefepime/taniborbactam and comparator agents against Gram-negative bacterial bloodstream pathogens recovered from patients with cancer. JAC-Antimicrobial Resistance 6(2), 2024. e-Pub 2024. PMID: 38601790.
- Axell-House, DB, Simar, SR, Panesso, D, Rincon, S, Miller, WR, Khan, A, Pemberton, OA, Valdez, L, Nguyen, AH, Hood, KS, Rydell, K, DeTranaltes, AM, Jones, MN, Atterstrom, R, Reyes, J, Sahasrabhojane, P, Suleyman, G, Zervos, MJ, Shelburne, S, Singh, KV, Shamoo, Y, Hanson, B, Tran, TT, Arias, CA. LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faecium. Antimicrobial agents and chemotherapy 68(3), 2024. e-Pub 2024. PMID: 38289081.
- Kawai, A, Shropshire, WC, Suzuki, M, Borjan, J, Aitken, SL, Bachman, WC, Mcelheny, CL, Bhatti, MM, Shields, RK, Shelburne, S, Doi, Y. Structural insights into the molecular mechanism of high-level ceftazidime–avibactam resistance conferred by CMY-185. mBio 15(2), 2024. e-Pub 2024. PMID: 38179965.
- Anand, SS, Wu, CT, Bremer, J, Bhatti, MM, Treangen, TJ, Kalia, A, Shelburne, S, Shropshire, WC. Identification of a novel CG307 sub-clade in third-generation-cephalosporin-resistant Klebsiella pneumoniae causing invasive infections in the USA. Microbial genomics 10(2), 2024. e-Pub 2024. PMID: 38407244.
- Shropshire, W, Amiji, H, Bremer, J, Selvaraj-Anand, S, Strope, B, Sahasrabhojane, P, Gohel, M, Aitken, SL, Spitznogle, S, Zhan, X, Kim, J, Greenberg, DE, Shelburne, S. Genetic determinants underlying the progressive phenotype of β-lactam/β-lactamase inhibitor resistance in Escherichia coli. Microbiology spectrum 11(6):e0222123, 2023. e-Pub 2023. PMID: 37800937.
- Shropshire, WC, Endres, BT, Borjan, J, Aitken, SL, Bachman, WC, Mcelheny, CL, Wu, CT, Egge, SL, Khan, A, Miller, WR, Bhatti, MM, Saharasbhojane, P, Kawai, A, Shields, RK, Shelburne, S, Doi, Y. High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated β-lactamase CMY-185 variant. Journal of Antimicrobial Chemotherapy 78(10):2442-2450, 2023. e-Pub 2023. PMID: 37574665.
- Shropshire, WC, Strope, B, Anand, SS, Bremer, J, McDaneld, PM, Bhatti, MM, Flores, AR, Kalia, A, Shelburne, S. Temporal dynamics of genetically heterogeneous extended-spectrum cephalosporin-resistant Escherichia coli bloodstream infections. mSphere 8(4), 2023. e-Pub 2023. PMID: 37427953.
- DebRoy, S, Shropshire, W, Vega, LA, Tran, CN, Horstmann, N, Mukherjee, P, Selvaraj-Anand, S, Tran, TT, Bremer, J, Gohel, M, Arias, CA, Flores, A, Shelburne, S. Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci. mSystems 8(4), 2023. e-Pub 2023. PMID: 37358280.
- Horstmann, N, Tran, CN, Flores, AR, Shelburne, S. Hyperphosphorylation of the Group A Streptococcal Control of Virulence Regulator Increases Promoter Occupancy Specifically at Virulence Factor-Encoding Genes. Journal of bacteriology 205(6), 2023. e-Pub 2023. PMID: 37289078.
- McMahon, S, Sahasrabhojane, P, Kim, J, Franklin, S, Chang, C, Jenq, RR, Hillhouse, A, Shelburne, S, Galloway-Pena, J. Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients. Microbiology spectrum 11(3), 2023. e-Pub 2023. PMID: 37022173.
- Gerges, B, Rolston, KV, Shelburne, S, Rosenblatt, J, Prince, RA, Raad, II. The in vitro activity of delafloxacin and comparator agents against bacterial pathogens isolated from patients with cancer. JAC-Antimicrobial Resistance 5(2), 2023. e-Pub 2023. PMID: 36994231.
- Rolston, KV, Gerges, B, Nesher, L, Shelburne, S, Prince, RA, Raad, II. In vitro activity of eravacycline and comparator agents against bacterial pathogens isolated from patients with cancer. JAC-Antimicrobial Resistance 5(2), 2023. e-Pub 2023. PMID: 36875177.
- Tran, TT, Cabrera, NL, Gonzales-Luna, AJ, Carlson, TJ, Alnezary, F, Miller, WR, Sakurai, A, Dinh, AQ, Rydell, K, Rios, R, Díaz, L, Hanson, BM, Munita, JM, Pedroza, C, Shelburne, S, Aitken, SL, Garey, K, Dillon, R, Puzniak, L, Arias, CA. Clinical characteristics, microbiology and outcomes of a cohort of patients treated with ceftolozane/tazobactam in acute care inpatient facilities, Houston, Texas, USA. JAC-Antimicrobial Resistance 5(1), 2023. e-Pub 2023. PMID: 36601551.
- Simar, SR, Tran, TT, Rydell, K, Panesso, D, Contreras, GA, Munita, JM, Cifuentes, RO, Abbo, LM, Sahasrabhojane, P, Dinh, AQ, Axell-House, DB, Savidge, TC, Shelburne, S, Hanson, BM, Arias, CA. Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida. Antimicrobial agents and chemotherapy 67(1), 2023. e-Pub 2023. PMID: 36541772.
- Schwabkey, Z, Wiesnoski, DH, Chang, C, Tsai, W, Pham, D, Ahmed, SS, Hayase, T, Ortega Turrubiates, MR, El-Himri, RK, Sanchez, CA, Hayase, E, Frenk Oquendo, AC, Miyama, T, Halsey, T, Heckel, BE, Brown, AN, Jin, Y, Raybaud, M, Prasad, R, Flores, I, McDaniel, L, Chapa, V, Lorenzi, PL, Warmoes, MO, Tan, L, Swennes, AG, Fowler, S, Conner, ME, McHugh, K, Graf, T, Jensen, VB, Peterson, CB, Do, K, Zhang, L, Shi, Y, Wang, Y, Galloway-Pena, J, Okhuysen, PC, Daniel-MacDougall, CR, Shono, Y, Burgos da Silva, M, Peled, JU, Van Den Brink, MR, Ajami, NJ, Wargo, J, Reddy, P, Valdivia, RH, Davey, L, Rondon, G, Srour, S, Mehta, RS, Alousi, AM, Shpall, E, Champlin, RE, Shelburne, S, Molldrem, JJ, Jamal, M, Karmouch, J, Jenq, RR. Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment. Science translational medicine 14(671), 2022. e-Pub 2022. PMID: 36383683.
- Tamma, PD, Komarow, L, Ge, L, Garcia-Diaz, J, Herc, ES, Doi, Y, Arias, CA, Albin, O, Saade, E, Miller, LG, Jacob, JT, Satlin, MJ, Krsak, M, Huskins, WC, Dhar, S, Shelburne, S, Hill, C, Baum, KR, Bhojani, M, Greenwood-Quaintance, KE, Schmidt-Malan, SM, Patel, R, Evans, S, Chambers, H, Fowler, VG, van Duin, D. Clinical Impact of Ceftriaxone Resistance in Escherichia coli Bloodstream Infections. Open Forum Infectious Diseases 9(11), 2022. e-Pub 2022. PMID: 36381622.
- Hayase, E, Hayase, T, Jamal, M, Miyama, T, Chang, C, Ortega, MR, Ahmed, SS, Karmouch, J, Sanchez, CA, Brown, AN, El-Himri, RK, Flores, I, McDaniel, L, Pham, D, Halsey, T, Frenk, AC, Chapa, V, Heckel, BE, Jin, Y, Tsai, W, Prasad, R, Tan, L, Veillon, L, Ajami, NJ, Wargo, J, Galloway-Pena, J, Shelburne, S, Chemaly, RF, Davey, L, Glowacki, RW, Liu, C, Rondon, G, Alousi, AM, Molldrem, JJ, Champlin, RE, Shpall, E, Valdivia, RH, Martens, EC, Lorenzi, PL, Jenq, RR. Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease. Cell 185(20):3705-3719.e14, 2022. e-Pub 2022. PMID: 36179667.
- Shropshire, WC, Konovalova, A, McDaneld, PM, Gohel, M, Strope, B, Sahasrabhojane, P, Tran, CN, Greenberg, DE, Kim, J, Zhan, X, Aitken, SL, Bhatti, MM, Savidge, TC, Treangen, TJ, Hanson, BM, Arias, CA, Shelburne, S. Systematic Analysis of Mobile Genetic Elements Mediating b-Lactamase Gene Amplification in Noncarbapenemase- Producing Carbapenem-Resistant Enterobacterales Bloodstream Infections. mSystems 7(5), 2022. e-Pub 2022. PMID: 36036505.
- Vega, LA, Sanson, M, Cubria, MB, Regmi, S, Shah, BJ, Shelburne, S, Flores, AR. The Integrative Conjugative Element ICESpyM92 Contributes to Pathogenicity of Emergent Antimicrobial-Resistant emm92 Group A Streptococcus. Infection and Immunity 90(8), 2022. e-Pub 2022. PMID: 35913172.
- Bhalodi, AA, Macvane, SH, Ford, B, Ince, D, Kinn, PM, Percival, KM, Bremmer, DN, Carr, DR, Walsh, TL, Bhatti, MM, Shelburne, S, Humphries, RM, Wolfe, K, Rosenbaum, ER, Dare, RK, Kolev, J, Madhusudhan, M, Ben-Aderet, MA, Morgan, MA. Real-World Impact of the Accelerate PhenoTest BC Kit on Patients with Bloodstream Infections in the Improving Outcomes and Antimicrobial Stewardship Study. Clinical Infectious Diseases 75(2):269-277, 2022. e-Pub 2022. PMID: 34718456.
- Rolston, KV, Gerges, B, Reitzel, R, Shelburne, S, Aitken, SL, Raad, II, Prince, RA. In vitro activity of imipenem/releactam and comparator agents against clinical bacterial isolates from patients with cancer. Journal of Global Antimicrobial Resistance 29:1-6, 2022. e-Pub 2022. PMID: 35121163.
- Shropshire, WC, Dinh, AQ, Earley, M, Komarow, L, Panesso, D, Rydell, K, Gómez-Villegas, SI, Miao, H, Hill, C, Chen, L, Patel, R, Fries, BC, Abbo, LM, Cober, E, Revolinski, S, Luterbach, CL, Chambers, H, Fowler, VG, Bonomo, RA, Shelburne, S, Kreiswirth, BN, van Duin, D, Hanson, BM, Arias, CA. Accessory Genomes Drive Independent Spread of Carbapenem- Resistant Klebsiella pneumoniae Clonal Groups 258 and 307 in Houston, TX. mBio 13(2), 2022. e-Pub 2022. PMID: 35357213.
- Franklin, S, Aitken, SL, Shi, Y, Sahasrabhojane, P, Robinson, S, Peterson, CB, Daver, N, Ajami, NJ, Kontoyiannis, DP, Shelburne, S, Galloway-Pena, J. Oral and Stool Microbiome Coalescence and Its Association With Antibiotic Exposure in Acute Leukemia Patients. Frontiers in Cellular and Infection Microbiology 12, 2022. e-Pub 2022. PMID: 35433514.
- Contreras, GA, Munita, JM, Simar, SR, Luterbach, CL, Dinh, AQ, Rydell, K, Sahasrabhojane, P, Rios, R, Díaz, L, Reyes, K, Zervos, MJ, Misikir, HM, Petitto, GS, Liu, C, Doi, Y, Abbo, LM, Shimose, LA, Seifert, H, Gudiol, C, Barberis, F, Pedroza, C, Aitken, SL, Shelburne, S, van Duin, D, Tran, TT, Hanson, BM, Arias, CA. Contemporary Clinical and Molecular Epidemiology of Vancomycin-Resistant Enterococcal Bacteremia. Open Forum Infectious Diseases 9(3), 2022. e-Pub 2022. PMID: 35155713.
- Horstmann, N, Myers, KS, Tran, CN, Flores, AR, Shelburne, S. CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A Streptococcus. PLoS pathogens 18(2), 2022. e-Pub 2022. PMID: 35180278.
- Sanson, M, Vega, LA, Shah, BJ, Regmi, S, Belen Cubria, M, Horstmann, N, Shelburne, S, Flores, AR. The LiaFSR Transcriptome Reveals an Interconnected Regulatory Network in Group A Streptococcus. Infection and Immunity 89(11), 2021. e-Pub 2021. PMID: 34370508.
- DebRoy, S, Shropshire, WC, Tran, CN, Hao, H, Gohel, M, Galloway-Pena, J, Hanson, BM, Flores, AR, Shelburne, S. Characterization of the Type I Restriction Modification System Broadly Conserved among Group A Streptococci. mSphere 6(6), 2021. e-Pub 2021. PMID: 34787444.
- DebRoy, S, Sanson, M, Shah, BJ, Regmi, S, Vega, LA, Odo, C, Sahasrabhojane, P, McGeer, A, Tyrrell, GJ, Fittipaldi, N, Shelburne, S, Flores, AR. Population genomics of emm4 group a streptococcus reveals progressive replacement with a hypervirulent clone in north america. mSystems 6(4), 2021. e-Pub 2021. PMID: 34374563.
- DebRoy, S, Aliaga-Tobar, V, Galvez, G, Arora, S, Liang, X, Horstmann, N, Maracaja-Coutinho, V, Latorre, M, Hook, M, Flores, AR, Shelburne, S. Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus. Molecular Microbiology 115(6):1207-1228, 2021. e-Pub 2021. PMID: 33325565.
- Olvera, AV, Carter, HE, Rajan, A, Carlin, LG, Yu, X, Zeng, XL, Shelburne, S, Bhatti, MM, Blutt, SE, Shroyer, NF, Jenq, RR, Estes, MK, Maresso, AW, Okhuysen, PC. Enteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients. Clinical Infectious Diseases 72(10):E620-E629, 2021. e-Pub 2021. PMID: 32930708.
- Aitken, SL, Sahasrabhojane, P, Kontoyiannis, DP, Savidge, TC, Arias, CA, Ajami, NJ, Shelburne, S, Galloway-Pena, J. Alterations of the Oral Microbiome and Cumulative Carbapenem Exposure Are Associated With Stenotrophomonas maltophilia Infection in Patients With Acute Myeloid Leukemia Receiving Chemotherapy. Clinical Infectious Diseases 72(9):1507-1513, 2021. e-Pub 2021. PMID: 32544947.
- Satlin, MJ, Weissman, SJ, Carpenter, P, Seo, SK, Shelburne, S. American Society of Transplantation and Cellular Therapy Series, 1. Transplantation and Cellular Therapy 27(2):108-114, 2021. e-Pub 2021. PMID: 33781545.
- Shropshire, WC, Aitken, SL, Pifer, R, Kim, J, Bhatti, MM, Li, X, Kalia, A, Galloway-Pena, J, Sahasrabhojane, P, Arias, CA, Greenberg, DE, Hanson, BM, Shelburne, S. IS26-mediated amplification of blaOXA-1and blaCTX-M-15with concurrent outer membrane porin disruption associated with de novo carbapenem resistance in a recurrent bacteraemia cohort. Journal of Antimicrobial Chemotherapy 76(2):385-395, 2021. e-Pub 2021. PMID: 33164081.
- Reyes-Gibby CC, Wang J, Zhang L, Peterson CB, Do KA, Jenq RR, Shelburne S, Shah DP, Chambers MS, Hanna EY, Yeung SJ, Shete S. Oral microbiome and onset of oral mucositis in patients with squamous cell carcinoma of the head and neck. Cancer 126(23):5124-5136, 2020. e-Pub 2020. PMID: 32888342.
- Galloway-Pena JR, Shi Y, Peterson CB, Sahasrabhojane P, Gopalakrishnan V, Brumlow CE, Daver NG, Alfayez M, Boddu PC, Khan MAW, Wargo JA, Do KA, Jenq RR, Kontoyiannis DP, Shelburne SA. Gut Microbiome Signatures Are Predictive of Infectious Risk Following Induction Therapy for Acute Myeloid Leukemia. Clin Infect Dis 71(1):63-71, 2020. e-Pub 2020. PMID: 31436833.
- Cabrera NL, Malek AE, Shelburne S, Taremi M, Awadh H, Francisco D, Robins A, Jabbour E, Chemaly RF. Disseminated cytomegalovirus infection with bilateral adrenal pseudotumors masquerading as recurrent hematologic malignancy. Infection 48(3):477-481, 2020. e-Pub 2020. PMID: 32144592.
- Shelburne SA, Dib RW, Endres BT, Reitzel R, Li X, Kalia A, Sahasrabhojane P, Chaftari AM, Hachem R, Vargas-Cruz NS, Jiang Y, Garey K, Fowler VG Jr, Holland TL, Gu J, Miller W, Sakurai A, Arias CA, Aitken SL, Greenberg DE, Kim J, Flores AR, Raad I. Whole-genome sequencing of Staphylococcus epidermidis bloodstream isolates from a prospective clinical trial reveals that complicated bacteraemia is caused by a limited number of closely related sequence types. Clin Microbiol Infect 26(5):646.e1-646.e8, 2020. e-Pub 2020. PMID: 31639470.
- Rolston KVI, Gerges B, Shelburne S, Aitken SL, Raad I, Prince RA. Activity of Cefiderocol and Comparators against Isolates from Cancer Patients. Antimicrob Agents Chemother 64(5), 2020. e-Pub 2020. PMID: 32071053.
- Robinson S, Peterson CB, Sahasrabhojane P, Ajami NJ, Shelburne SA, Kontoyiannis DP, Galloway-Pena JR. Observational Cohort Study of Oral Mycobiome and Interkingdom Interactions over the Course of Induction Therapy for Leukemia. mSphere 5(2), 2020. e-Pub 2020. PMID: 32295867.
- Flores AR, Shelburne SA. Toward an Understanding of Group A Streptococcal Transmission Dynamics Using National-level Surveillance. Clin Infect Dis 70(7):1482-1483, 2020. e-Pub 2020. PMID: 31408107.
- Arora S, Li X, Hillhouse A, Konganti K, Little SV, Lawhon SD, Threadgill D, Shelburne S, Hook M. Staphylococcus epidermidis MSCRAMM SesJ Is Encoded in Composite Islands. mBio 11(1), 2020. e-Pub 2020. PMID: 32071265.
- Kim J, Greenberg DE, Pifer R, Jiang S, Xiao G, Shelburne SA, Koh A, Xie Y, Zhan X. VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learning. PLoS Comput Biol 16(1):e1007511, 2020. e-Pub 2020. PMID: 31929521.
- Munoz NM, Minhaj AA, Dupuis CJ, Ensor JE, Golardi N, Jaso JM, Dixon KA, Figueira TA, Galloway-Pena JR, Hill L, Shelburne SA, Tam AL. What Are the Effects of Irreversible Electroporation on a Staphylococcus aureus Rabbit Model of Osteomyelitis?. Clin Orthop Relat Res 477(10):2367-2377, 2019. e-Pub 2019. PMID: 31393339.
- Flores AR, Chase McNeil J, Shah B, Van Beneden C, Shelburne SA. Capsule-Negative emm Types Are an Increasing Cause of Pediatric Group A Streptococcal Infections at a Large Pediatric Hospital in Texas. J Pediatric Infect Dis Soc 8(3):244-250, 2019. e-Pub 2019. PMID: 30085121.
- Galloway-Pena JR, Peterson CB, Malik F, Sahasrabhojane PV, Shah DP, Brumlow CE, Carlin LG, Chemaly RF, Im JS, Rondon G, Felix E, Veillon L, Lorenzi PL, Alousi AM, Jenq RR, Kontoyiannis DP, Shpall EJ, Shelburne SA, Okhuysen PC. Fecal Microbiome, Metabolites, and Stem Cell Transplant Outcomes: A Single-Center Pilot Study. Open Forum Infect Dis 6(5):ofz173, 2019. e-Pub 2019. PMID: 31065565.
- Tran TT, Mishra NN, Seepersaud R, Diaz L, Rios R, Dinh AQ, Garcia-de-la-Maria C, Rybak MJ, Miro JM, Shelburne SA, Sullam PM, Bayer AS, Arias CA. Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother 63(2), 2019. e-Pub 2019. PMID: 30509945.
- Benanti GE, Brown ART, Shigle TL, Tarrand JJ, Bhatti MM, McDaneld PM, Shelburne SA, Aitken SL. Carbapenem versus Cefepime or Piperacillin-Tazobactam for Empiric Treatment of Bacteremia Due to Extended-Spectrum-beta-Lactamase-Producing Escherichia coli in Patients with Hematologic Malignancy. Antimicrob Agents Chemother 63(2), 2019. e-Pub 2019. PMID: 30509935.
- DebRoy S, Li X, Kalia A, Galloway-Pena J, Shah BJ, Fowler VG, Flores AR, Shelburne SA. Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus. Microb Genom 4(11), 2018. e-Pub 2018. PMID: 30412460.
- Horstmann N, Tran CN, Brumlow C, DebRoy S, Yao H, Nogueras Gonzalez G, Makthal N, Kumaraswami M, Shelburne SA. Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus. PLoS Pathog 14(10):e1007354, 2018. e-Pub 2018. PMID: 30379939.
- Foolad F, Taylor BD, Shelburne SA, Arias CA, Aitken SL. Association of daptomycin dosing regimen and mortality in patients with VRE bacteraemia: a review. J Antimicrob Chemother 73(9):2277-2283, 2018. e-Pub 2018. PMID: 29547977.
- Rolston KVI, Reitzel R, Vargas-Cruz N, Shelburne SA, Raad II, Prince RA. In vitro activity of tedizolid and comparator agents against clinical Gram-positive isolates recovered from patients with cancer. Diagn Microbiol Infect Dis 91(4):351-353, 2018. e-Pub 2018. PMID: 29661529.
- Lacourt TE, Kavelaars A, Ohanian M, Shah ND, Shelburne SA, Futreal A, Kontoyiannis DP, Heijnen CJ. Patient-reported fatigue prior to treatment is prognostic of survival in patients with acute myeloid leukemia. Oncotarget 9(58):31244-31252, 2018. e-Pub 2018. PMID: 30131851.
- Li X, Arias CA, Aitken SL, Galloway Pena J, Panesso D, Chang M, Diaz L, Rios R, Numan Y, Ghaoui S, DebRoy S, Bhatti MM, Simmons DE, Raad I, Hachem R, Folan SA, Sahasarabhojane P, Kalia A, Shelburne SA. Clonal Emergence of Invasive Multidrug-Resistant Staphylococcus epidermidis Deconvoluted via a Combination of Whole-Genome Sequencing and Microbiome Analyses. Clin Infect Dis 67(3):398-406, 2018. e-Pub 2018. PMID: 29546356.
- Folan SA, Marx KR, Tverdek FP, Raad I, Mulanovich VE, Tarrand JJ, Shelburne SA, Aitken SL. Clinical Outcomes Associated With Linezolid Resistance in Leukemia Patients With Linezolid-Resistant Staphylococcus epidermidis Bacteremia. Open Forum Infect Dis 5(7):ofy167, 2018. e-Pub 2018. PMID: 30090838.
- Lacourt TE, Kavelaars A, Galloway-Pena JR, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ. Associations of inflammation with symptom burden in patients with acute myeloid leukemia. Psychoneuroendocrinology 89:203-208, 2018. e-Pub 2018. PMID: 29414033.
- Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Szczepaniak Sloane R, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Marcelo Riquelme Sanchez E, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, Austin-Breneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359(6371):97-103, 2018. e-Pub 2018. PMID: 29097493.
- Galloway-Pena J, DebRoy S, Brumlow C, Li X, Tran TT, Horstmann N, Yao H, Chen K, Wang F, Pan BF, Hawke DH, Thompson EJ, Arias CA, Fowler VG Jr, Bhatti MM, Kalia A, Flores AR, Shelburne SA. Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface. PLoS One 13(12):e0207897, 2018. e-Pub 2018. PMID: 30517150.
- Horstmann N, Sahasrabhojane P, Yao H, Su X, Shelburne SA. Use of a Phosphorylation Site Mutant To Identify Distinct Modes of Gene Repression by the Control of Virulence Regulator (CovR) in Streptococcus pyogenes. J Bacteriol 199(18), 2017. e-Pub 2017. PMID: 28289082.
- Shelburne SA, Kim J, Munita JM, Sahasrabhojane P, Shields RK, Press EG, Li X, Arias CA, Cantarel B, Jiang Y, Kim MS, Aitken SL, Greenberg DE. Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum beta-Lactams for Major Gram-Negative Bacterial Pathogens. Clin Infect Dis 65(5):738-745, 2017. e-Pub 2017. PMID: 28472260.
- Munita JM, Aitken SL, Miller WR, Perez F, Rosa R, Shimose LA, Lichtenberger PN, Abbo LM, Jain R, Nigo M, Wanger A, Araos R, Tran TT, Adachi J, Rakita R, Shelburne S, Bonomo RA, Arias CA. Multicenter Evaluation of Ceftolozane/Tazobactam for Serious Infections Caused by Carbapenem-Resistant Pseudomonas aeruginosa. Clin Infect Dis 65(1):158-161, 2017. e-Pub 2017. PMID: 28329350.
- Flores AR, Luna RA, Runge JK, Shelburne SA, Baker CJ. Cluster of Fatal Group A Streptococcal emm87 Infections in a Single Family: Molecular Basis for Invasion and Transmission. J Infect Dis 215(11):1648-1652, 2017. e-Pub 2017. PMID: 28383686.
- Rolston KVI, Jamal MA, Nesher L, Shelburne SA, Raad I, Prince RA. In vitro activity of ceftaroline and comparator agents against Gram-positive and Gram-negative clinical isolates from cancer patients. Int J Antimicrob Agents 49(4):416-421, 2017. e-Pub 2017. PMID: 28257904.
- DiPippo AJ, Tverdek FP, Tarrand JJ, Munita JM, Tran TT, Arias CA, Shelburne SA, Aitken SL. Daptomycin non-susceptible Enterococcus faecium in leukemia patients: Role of prior daptomycin exposure. J Infect 74(3):243-247, 2017. e-Pub 2017. PMID: 27845153.
- Galloway-Pena JR, Smith DP, Sahasrabhojane P, Wadsworth WD, Fellman BM, Ajami NJ, Shpall EJ, Daver N, Guindani M, Petrosino JF, Kontoyiannis DP, Shelburne SA. Characterization of oral and gut microbiome temporal variability in hospitalized cancer patients. Genome Med 9(1):21, 2017. e-Pub 2017. PMID: 28245856.
- Wadsworth WD, Argiento R, Guindani M, Galloway-Pena J, Shelburne SA, Vannucci M. An integrative Bayesian Dirichlet-multinomial regression model for the analysis of taxonomic abundances in microbiome data. BMC Bioinformatics 18(1):94, 2017. e-Pub 2017. PMID: 28178947.
- Munita JM, Shelburne S, Greenberg DE, Arias CA. The Growing Threat of Antimicrobial Resistance. Tex Med 113(2):48-52, 2017. e-Pub 2017. PMID: 28207079.
- Reyes-Gibby CC, Melkonian SC, Wang J, Yu RK, Shelburne SA, Lu C, Gunn GB, Chambers MS, Hanna EY, Yeung SJ, Shete S. Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis. PLoS One 12(7):e0180396, 2017. e-Pub 2017. PMID: 28678827.
- Bhatti MD, Kalia A, Sahasrabhojane P, Kim J, Greenberg DE, Shelburne SA. Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection. Front Microbiol 8:62, 2017. e-Pub 2017. PMID: 28174569.
- Aitken SL, Tarrand JJ, Deshpande LM, Tverdek FP, Jones AL, Shelburne SA, Prince RA, Bhatti MM, Rolston KVI, Jones RN, Castanheira M, Chemaly RF. High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-beta-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center. Clin Infect Dis 63(7):954-958, 2016. e-Pub 2016. PMID: 27313265.
- DebRoy S, Saldana M, Travisany D, Montano A, Galloway-Pena J, Horstmann N, Yao H, Gonzalez M, Maass A, Latorre M, Shelburne SA. A Multi-Serotype Approach Clarifies the Catabolite Control Protein A Regulon in the Major Human Pathogen Group A Streptococcus. Sci Rep 6:32442, 2016. e-Pub 2016. PMID: 27580596.
- Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-beta-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother 60(9):5130-4, 2016. e-Pub 2016. PMID: 27551008.
- Galloway-Pena JR, Smith DP, Sahasrabhojane P, Ajami NJ, Wadsworth WD, Daver NG, Chemaly RF, Marsh L, Ghantoji SS, Pemmaraju N, Garcia-Manero G, Rezvani K, Alousi AM, Wargo JA, Shpall EJ, Futreal PA, Guindani M, Petrosino JF, Kontoyiannis DP, Shelburne SA. The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia. Cancer 122(14):2186-96, 2016. e-Pub 2016. PMID: 27142181.
- Zhu L, Olsen RJ, Horstmann N, Shelburne SA, Fan J, Hu Y, Musser JM. Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes. Infect Immun 84(7):2086-2093, 2016. e-Pub 2016. PMID: 27141081.
- Shukla BS, Shelburne S, Reyes K, Kamboj M, Lewis JD, Rincon SL, Reyes J, Carvajal LP, Panesso D, Sifri CD, Zervos MJ, Pamer EG, Tran TT, Adachi J, Munita JM, Hasbun R, Arias CA. Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated With Daptomycin: Is it Time to Change the Breakpoint?. Clin Infect Dis 62(12):1514-1520, 2016. e-Pub 2016. PMID: 27045126.
- Rolston KV, Wang W, Nesher L, Shelburne SA, Prince RA. In vitro activity of dalbavancin and five comparator agents against common and uncommon Gram-positive organisms isolated from cancer patients. J Antibiot (Tokyo) 69(5):381-7, 2016. e-Pub 2016. PMID: 26626876.
- Petrosyan V, Holder M, Ajami NJ, Petrosino JF, Sahasrabhojane P, Thompson EJ, Kalia A, Shelburne SA. Complete Genome Sequence of Streptococcus mitis Strain SVGS_061 Isolated from a Neutropenic Patient with Viridans Group Streptococcal Shock Syndrome. Genome Announc 4(2), 2016. e-Pub 2016. PMID: 27056234.
- Galloway-Pena J, Clement ME, Sharma Kuinkel BK, Ruffin F, Flores AR, Levinson H, Shelburne SA, Moore Z, Fowler VG Jr. Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease. Open Forum Infect Dis 3(1):ofw042, 2016. e-Pub 2016. PMID: 27006966.
- Miller EW, Danger JL, Ramalinga AB, Horstmann N, Shelburne SA, Sumby P. Regulatory rewiring confers serotype-specific hyper-virulence in the human pathogen group A Streptococcus. Mol Microbiol 98(3):473-89, 2015. e-Pub 2015. PMID: 26192205.
- Teatero S, Athey TB, Van Caeseele P, Horsman G, Alexander DC, Melano RG, Li A, Flores AR, Shelburne SA, McGeer A, Demczuk W, Martin I, Fittipaldi N. Emergence of Serotype IV Group B Streptococcus Adult Invasive Disease in Manitoba and Saskatchewan, Canada, Is Driven by Clonal Sequence Type 459 Strains. J Clin Microbiol 53(9):2919-26, 2015. e-Pub 2015. PMID: 26135871.
- Flores AR, Galloway-Pena J, Sahasrabhojane P, Saldana M, Yao H, Su X, Ajami NJ, Holder ME, Petrosino JF, Thompson E, Margarit Y Ros I, Rosini R, Grandi G, Horstmann N, Teatero S, McGeer A, Fittipaldi N, Rappuoli R, Baker CJ, Shelburne SA. Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes. Proc Natl Acad Sci U S A 112(20):6431-6, 2015. e-Pub 2015. PMID: 25941374.
- Horstmann N, Sahasrabhojane P, Saldana M, Ajami NJ, Flores AR, Sumby P, Liu CG, Yao H, Su X, Thompson E, Shelburne SA. Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus. Infect Immun 83(3):1068-77, 2015. e-Pub 2015. PMID: 25561708.
- Galloway-Pena JR, Liang X, Singh KV, Yadav P, Chang C, La Rosa SL, Shelburne S, Ton-That H, Hook M, Murray BE. The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions. J Bacteriol 197(5):882-92, 2015. e-Pub 2015. PMID: 25512313.
- Shelburne SA, Ajami NJ, Chibucos MC, Beird HC, Tarrand J, Galloway-Pena J, Albert N, Chemaly RF, Ghantoji SS, Marsh L, Pemmaraju N, Andreeff M, Shpall EJ, Wargo JA, Rezvani K, Alousi A, Bruno VM, Futreal PA, Petrosino JF, Kontoyiannis DP. Implementation of a Pan-Genomic Approach to Investigate Holobiont-Infecting Microbe Interaction: A Case Report of a Leukemic Patient with Invasive Mucormycosis. PLoS One 10(11):e0139851, 2015. e-Pub 2015. PMID: 26556047.
- Shelburne SA, Chaftari AM, Jamal M, Al Wohoush I, Jiang Y, Abughazaleh S, Cairo J, Raad S, Debiane L, Raad I. Identification and characterization of catheter-related bloodstream infections due to viridans group streptococci in patients with cancer. Am J Infect Control 42(10):1127-9, 2014. e-Pub 2014. PMID: 25278410.
- Flores AR, Jewell BE, Olsen RJ, Shelburne SA, Fittipaldi N, Beres SB, Musser JM. Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production. Infect Immun 82(9):3958-67, 2014. e-Pub 2014. PMID: 25024363.
- Galloway-Pena J, Sahasrabhojane P, Tarrand J, Han XY, Shelburne SA. GyrB polymorphisms accurately assign invasive viridans group streptococcal species. J Clin Microbiol 52(8):2905-12, 2014. e-Pub 2014. PMID: 24899021.
- Shelburne SA, Lasky RE, Sahasrabhojane P, Tarrand JT, Rolston KV. Development and validation of a clinical model to predict the presence of beta-lactam resistance in viridans group streptococci causing bacteremia in neutropenic cancer patients. Clin Infect Dis 59(2):223-30, 2014. e-Pub 2014. PMID: 24755857.
- Rolston K 6th, Wang W, Nesher L, Coyle E, Shelburne S, Prince RA. In vitro activity of telavancin compared with vancomycin and linezolid against Gram-positive organisms isolated from cancer patients. J Antibiot (Tokyo) 67(7):505-9, 2014. e-Pub 2014. PMID: 24824818.
- Sahasrabhojane P, Galloway-Pena J, Velazquez L, Saldana M, Horstmann N, Tarrand J, Shelburne SA. Species-level assessment of the molecular basis of fluoroquinolone resistance among viridans group streptococci causing bacteraemia in cancer patients. Int J Antimicrob Agents 43(6):558-62, 2014. e-Pub 2014. PMID: 24721231.
- Flores AR, Sahasrabhojane P, Saldana M, Galloway-Pena J, Olsen RJ, Musser JM, Shelburne SA. Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient. J Infect Dis 209(10):1520-3, 2014. e-Pub 2014. PMID: 24307742.
- El Zakhem A, Chaftari AM, Bahu R, El Helou G, Shelburne S, Jiang Y, Hachem R, Raad I. Central line-associated bloodstream infections caused by Staphylococcus aureus in cancer patients: Clinical outcome and management. Ann Med 46(3):163-8, 2014. e-Pub 2014. PMID: 24491173.
- Horstmann N, Saldana M, Sahasrabhojane P, Yao H, Su X, Thompson E, Koller A, Shelburne SA. Dual-site phosphorylation of the control of virulence regulator impacts group a streptococcal global gene expression and pathogenesis. PLoS Pathog 10(5):e1004088, 2014. e-Pub 2014. PMID: 24788524.
- Shelburne SA, Sahasrabhojane P, Saldana M, Yao H, Su X, Horstmann N, Thompson E, Flores AR. Streptococcus mitis strains causing severe clinical disease in cancer patients. Emerg Infect Dis 20(5):762-71, 2014. e-Pub 2014. PMID: 24750901.
- Flores AR, Olsen RJ, Wunsche A, Kumaraswami M, Shelburne SA, Carroll RK, Musser JM. Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains. Infect Immun 81(11):4128-38, 2013. e-Pub 2013. PMID: 23980109.
- Shelburne SA, Tarrand J, Rolston KV. Review of streptococcal bloodstream infections at a comprehensive cancer care center, 2000-2011. J Infect 66(2):136-46, 2013. e-Pub 2013. PMID: 23182968.
- White CN, Shelburne S. Streptococcal infections: understanding the various species and strains. JAAPA 25(11):23-4, 2012. e-Pub 2012. PMID: 23620919.
- Horstmann N, Orans J, Valentin-Hansen P, Shelburne SA 3rd, Brennan RG. Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract. Nucleic Acids Res 40(21):11023-35, 2012. e-Pub 2012. PMID: 22965117.
- Olsen RJ, Laucirica DR, Watkins ME, Feske ML, Garcia-Bustillos JR, Vu C, Cantu C, Shelburne SA, Fittipaldi N, Kumaraswami M, Shea PR, Flores AR, Beres SB, Lovgren M, Tyrrell GJ, Efstratiou A, Low DE, Van Beneden CA, Musser JM. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus. J Infect Dis 205(11):1719-29, 2012. e-Pub 2012. PMID: 22262791.
- Lin E, Bhusal Y, Horwitz D, Shelburne SA, Trautner BW. Overtreatment of enterococcal bacteriuria. Arch Intern Med 172(1):33-8, 2012. e-Pub 2012. PMID: 22232145.
- Shelburne SA, Olsen RJ, Makthal N, Brown NG, Sahasrabhojane P, Watkins EM, Palzkill T, Musser JM, Kumaraswami M. An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes. Mol Microbiol 82(6):1481-95, 2011. e-Pub 2011. PMID: 22040048.
- Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen RJ, Flores A, Musser JM, Brennan RG, Shelburne SA. Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. PLoS Pathog 7(10):e1002311, 2011. e-Pub 2011. PMID: 22028655.
- Shelburne SA, Sahasrobhajane P, Suber B, Keith DB, Davenport MT, Horstmann N, Kumaraswami M, Olsen RJ, Brennan RG, Musser JM. Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. Mol Microbiol 81(2):500-14, 2011. e-Pub 2011. PMID: 21645132.
- Carroll RK, Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. J Clin Invest 121(5):1956-68, 2011. e-Pub 2011. PMID: 21490401.
- Kung DH, Hubenthal EA, Kwan JY, Shelburne SA, Goodman JC, Kass JS. Toxoplasmosis myelopathy and myopathy in an AIDS patient: a case of immune reconstitution inflammatory syndrome?. Neurologist 17(1):49-51, 2011. e-Pub 2011. PMID: 21192196.
- Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Sumby P, Brennan RG, Musser JM. A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. PLoS Pathog 6(3):e1000817, 2010. e-Pub 2010. PMID: 20333240.
- Trevino J, Perez N, Ramirez-Pena E, Liu Z, Shelburne SA, Musser JM, Sumby P. CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes. Infect Immun 77(8):3141-9, 2009. e-Pub 2009. PMID: 19451242.
- Livorsi DJ, Daver NG, Atmar RL, Shelburne SA, White AC Jr, Musher DM. Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA ERA. J Infect 57(2):128-31, 2008. e-Pub 2008. PMID: 18562009.
- Shelburne SA, Keith DB, Davenport MT, Horstmann N, Brennan RG, Musser JM. Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis. Mol Microbiol 69(2):436-52, 2008. e-Pub 2008. PMID: 18485073.
- Shelburne SA, Keith D, Horstmann N, Sumby P, Davenport MT, Graviss EA, Brennan RG, Musser JM. A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. Proc Natl Acad Sci U S A 105(5):1698-703, 2008. e-Pub 2008. PMID: 18230719.
- Shelburne SA, Singh KV, White AC Jr, Byrne L, Carmer A, Austin C, Graviss E, Stager C, Murray BE, Atmar RL. Sequential outbreaks of infections by distinct Acinetobacter baumannii strains in a public teaching hospital in Houston, Texas. J Clin Microbiol 46(1):198-205, 2008. e-Pub 2008. PMID: 18003801.
- Shelburne SA, Okorafor N, Sitkiewicz I, Sumby P, Keith D, Patel P, Austin C, Graviss EA, Musser JM. Regulation of polysaccharide utilization contributes to the persistence of group a streptococcus in the oropharynx. Infect Immun 75(6):2981-90, 2007. e-Pub 2007. PMID: 17403878.
- Daver NG, Shelburne SA, Atmar RL, Giordano TP, Stager CE, Reitman CA, White AC Jr. Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis. J Infect 54(6):539-44, 2007. e-Pub 2007. PMID: 17198732.
- Shelburne SA, Fang H, Okorafor N, Sumby P, Sitkiewicz I, Keith D, Patel P, Austin C, Graviss EA, Musser JM, Chow DC. MalE of group A Streptococcus participates in the rapid transport of maltotriose and longer maltodextrins. J Bacteriol 189(7):2610-7, 2007. e-Pub 2007. PMID: 17259319.
- Shelburne SA, Greenberg SB, Aslam S, Tweardy DJ. Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci. J Infect 54(2):e99-101, 2007. e-Pub 2007. PMID: 16824611.
- Gonzalez BE, Rueda AM, Shelburne SA, Musher DM, Hamill RJ, Hulten KG. Community-associated strains of methicillin-resistant Staphylococccus aureus as the cause of healthcare-associated infection. Infect Control Hosp Epidemiol 27(10):1051-6, 2006. e-Pub 2006. PMID: 17006811.
- Kaka AS, Rueda AM, Shelburne SA, Hulten K, Hamill RJ, Musher DM. Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 58(3):680-3, 2006. e-Pub 2006. PMID: 16840428.
- Shelburne SA, Sumby P, Sitkiewicz I, Okorafor N, Granville C, Patel P, Voyich J, Hull R, DeLeo FR, Musser JM. Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx. Infect Immun 74(8):4605-14, 2006. e-Pub 2006. PMID: 16861648.
- Shelburne SA, Sumby P, Sitkiewicz I, Granville C, DeLeo FR, Musser JM. Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva. Proc Natl Acad Sci U S A 102(44):16037-42, 2005. e-Pub 2005. PMID: 16249338.
- Shelburne SA, Visnegarwala F, Adams C, Krause KL, Hamill RJ, White AC Jr. Unusual manifestations of disseminated Histoplasmosis in patients responding to antiretroviral therapy. Am J Med 118(9):1038-41, 2005. e-Pub 2005. PMID: 16164892.
- Shelburne SA, Granville C, Tokuyama M, Sitkiewicz I, Patel P, Musser JM. Growth characteristics of and virulence factor production by group A Streptococcus during cultivation in human saliva. Infect Immun 73(8):4723-31, 2005. e-Pub 2005. PMID: 16040985.
- Shelburne SA, Darcourt J, White AC Jr, Greenberg SB, Hamill RJ, Atmar RL, Visnegarwala F. The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy. Clin Infect Dis 40(7):1049-52, 2005. e-Pub 2005. PMID: 15825000.
- Shelburne SA, Visnegarwala F, Darcourt J, Graviss EA, Giordano TP, White AC Jr, Hamill RJ. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS 19(4):399-406, 2005. e-Pub 2005. PMID: 15750393.
- Shelburne SA, Musher DM, Hulten K, Ceasar H, Lu MY, Bhaila I, Hamill RJ. In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations. Antimicrob Agents Chemother 48(10):4016-9, 2004. e-Pub 2004. PMID: 15388469.
- Shelburne SA, Kielhofner MA, Tiwari PS. Cerebellar involvement in legionellosis. South Med J 97(1):61-4, 2004. e-Pub 2004. PMID: 14746424.
- Shelburne SA, Hamill RJ, Rodriguez-Barradas MC, Greenberg SB, Atmar RL, Musher DW, Gathe JC Jr, Visnegarwala F, Trautner BW. Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore) 81(3):213-27, 2002. e-Pub 2002. PMID: 11997718.
Review Articles
- Shropshire WC, Hanson BM, Shelburne SA. Genome-wide approaches to bacterial strain typing: a history and review of recent methodological advances. Curr Opin Infect Dis 38(4):329-338, 2025. e-Pub 2025. PMID: 40464921.
- Mojica, MF, Humphries, RM, Lipuma, JJ, Mathers, AJ, Rao, GG, Shelburne, S, Fouts, DE, van Duin, D, Bonomo, RA. Clinical challenges treating Stenotrophomonas maltophilia infections. JAC-Antimicrobial Resistance 4(3), 2022. e-Pub 2022. PMID: 35529051.
- Shah, S, Shelburne, S. Skin and Soft Tissue Infections in Non–Human Immunodeficiency Virus Immunocompromised Hosts. Infectious Disease Clinics of North America 35(1):199-217, 2021. e-Pub 2021. PMID: 33303336.
- Galloway-Pena J, Brumlow C, Shelburne S. Impact of the Microbiota on Bacterial Infections during Cancer Treatment. Trends Microbiol 25(12):992-1004, 2017. e-Pub 2017. PMID: 28728967.
- Galloway-Pena JR, Jenq RR, Shelburne SA. Can Consideration of the Microbiome Improve Antimicrobial Utilization and Treatment Outcomes in the Oncology Patient?. Clin Cancer Res 23(13):3263-3268, 2017. e-Pub 2017. PMID: 28298544.
- Holland T, Fowler VG Jr, Shelburne SA. Invasive gram-positive bacterial infection in cancer patients. Clin Infect Dis 59 Suppl 5(Suppl 5):S331-4, 2014. e-Pub 2014. PMID: 25352626.
- Musser JM, Shelburne SA. A decade of molecular pathogenomic analysis of group A Streptococcus. J Clin Invest 119(9):2455-63, 2009. e-Pub 2009. PMID: 19729843.
- Safdar A, Shelburne SA, Evans SE, Dickey BF. Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf 8(4):435-49, 2009. e-Pub 2009. PMID: 19538104.
- Olsen RJ, Shelburne SA, Musser JM. Molecular mechanisms underlying group A streptococcal pathogenesis. Cell Microbiol 11(1):1-12, 2009. e-Pub 2009. PMID: 18710460.
- Shelburne SA, Davenport MT, Keith DB, Musser JM. The role of complex carbohydrate catabolism in the pathogenesis of invasive streptococci. Trends Microbiol 16(7):318-25, 2008. e-Pub 2008. PMID: 18508271.
- Shelburne SA, Montes M, Hamill RJ. Immune reconstitution inflammatory syndrome: more answers, more questions. J Antimicrob Chemother 57(2):167-70, 2006. e-Pub 2006. PMID: 16354748.
- Shelburne SA, Musser JM. Virulence gene expression in vivo. Curr Opin Microbiol 7(3):283-9, 2004. e-Pub 2004. PMID: 15196497.
- Shelburne SA, Hamill RJ. The immune reconstitution inflammatory syndrome. AIDS Rev 5(2):67-79, 2003. e-Pub 2003. PMID: 12876896.
Other Articles
- Torres, HA, Mustafayev, K, Nastoupil, L, Shelburne, S Severe reactivation of seronegative occult hepatitis B after chemotherapy for lymphoma. The Lancet 403(10434):1372-1373, 2024. PMID: 38582568.
- Wadsworth WD, Argiento R, Guindani M, Galloway-Pena J, Shelburne SA, Vannucci M Erratum to: An integrative Bayesian Dirichlet-multinomial regression model for the analysis of taxonomic abundances in microbiome data. BMC Bioinformatics 18(1):185, 2017. PMID: 28335713.
Editorials
- Shropshire WC, Shelburne SA. Antimicrobial resistance: a problem across the cancer care continuum. Lancet Oncol 26(5):537-538, 2025. PMID: 40318640.
- Hanage WP, Shelburne SA. Streptococcus pyogenes With Reduced Susceptibility to beta-Lactams: How Big an Alarm Bell?. Clin Infect Dis 71(1):205-206, 2020. PMID: 31630163.
Abstracts
- Koenig AN, Lui C, Zhang J, Hu PC, Thompson EJ, Shelburne SA, Kalia A. Population Genomics of the Streptococcus dysgalactiae subspecies equisimilis FCT-locus Reveals a Diverse Array of FCT Architectures & Shared Gene Contact with Group A Streptoccus. ASM Microbe 2019, 2019. e-Pub 2019.
- Wilson Dib R, Li X, Shelburne SA, Chaftari AM, Hachem RY, Reitzel R, Vargas-Cruz N, Holland TL, Fowler Jr VG, Raad I. Whole Genome Sequencing Analysis of a Large Cohort of Staphylococcus epidermidis Blood Culture Positive Isolates from a Multicenter Clinical Trial. Infectious Diseases of America Annual Meeting, 2018. e-Pub 2018.
- Contreras G, Munita JM, Reyes KC, Sahasrabhojane P, Misikir H, Garza H, Zervos MJ, Aitken SL, Shelburne SA, Arias C. VENOUS 1: A Prospective Multicenter Cohort Study of Enterococcal Bacteremia. Infectious Diseases of America Annual Meeting, 2018. e-Pub 2018.
- S L Aitken SL, Bhatti M, Sahasrabhojane P, Galloway-Pena J, Li X, Tverdek FP, Reeves C, McDaneld P, Greenberg D, Shelburne S. Epidemiology and Mechanisms of Carbapenem Resistance in Recurrent Extended-Spectrum β-lactamase- Producing Enterobacteriaceae Bacteremia. Infectious Diseases of America Annual Meeting, 2018. e-Pub 2018.
- Flores AR, Galloway-Pena J, Shelburne III SA. High prevalence of antimicrobial resistance genes uncovered through whole genome sequencing of sequence Type 1 Group B Streptococcus. ASM Microbe 2018, 2018. e-Pub 2018.
- Galloway-Peña J, DebRoy S, Brumlow C, Li X, Horstmann N, Yao H, Chen K, Bhatti M, Kalia A, Shelburne S. Hypervirulent Group A Streptococcus Emergence in an Acaspular Background is Associated with Marked Remodeling of the Bacterial Cell Surface. Research Retreat, Division of Internal Medicine, MD Anderson Cancer Center, 2018. e-Pub 2018.
- Horstmann N, Tran C, DebRoy S, Brumlow C, Yao H, Makthal N, Kumaraswami M, Shelburne S. CovS phosphatase activity is pivotal for Streptococcus pyogenes virulence. Research Retreat, Division of Internal Medicine, MD Anderson Cancer Center, 2018. e-Pub 2018.
- Contreras G, Diaz L, Rios R, Reyes KC, Kamboj M, Lewis J, Rincon S, Reyes J, Carvajal LP, Panesso D, Sifri CD, Zervos M, Pamer E, Tran TT, Shelburne S, Munita J, Arias C. A Whole Genome Sequencing (WGS) Approach to Predict Daptomycin (DAP) Susceptibility of Enterococcus faecium. Infectious Diseases of America Annual Meeting, 2017. e-Pub 2017.
- Jandhyala D, Mulanovich VE, Aitken S, Tverdek F, Chemaly R, Marx K, Rolston KV, SHELBURNE SA. A contemporary analysis of neutropenic fever in leukemia patients presenting to the emergency center – importance of pneumonia. Infectious Diseases Society of America Annual Meeting, 2017. e-Pub 2017.
- Aitken S, Jandhyala D, Mulanovich VE Marx K, Tverdek F, Chemaly R, Rolston KV, SHELBURNE SA. Patterns of linezolid and daptomycin use in leukemia patients with neutropenic fever presenting to the emergency center. Infectious Diseases Society of America Annual Meeting, 2017. e-Pub 2017.
- Jandhyala D, Mulanovich VE, Aitken S, Tverdek F, Marx K, Chemaly R, Rolston KV, SHELBURNE SA. Prophylactic antibiotic therapy and bloodstream infections in leukemia patients presenting to the emergency center. Infectious Diseases Society of America Annual Meeting, 2017. e-Pub 2017.
- Wilson Dib R, Numan Y, Li X, Kalia A, Raad I, SHELBURNE SA. Invasive Staphylococcus epidermidis isolates are highly clonal and distinct from commensal strains: time for a new paradigm in infection control?. Infectious Diseases Society of America Annual Meeting, 2017. e-Pub 2017.
- Galloway-Peña J, Shah D, Sahasrabohjane P, Brumlow C, Carlin L, Peterson L, Alousi A, Shpall E, Chemaly R, Kontoyiannis D, SHELBURNE SA, Okhuysen P. Irreversible electroporation combined with parenteral antibiotics enhances treatment of osteomyelitis caused by Staphylococcus aureus in a rabbit model. Radiological Society of North America (RSNA) Conference, 2017. e-Pub 2017.
- Muñoz N, Minhaj A, Golardi A, Jasso JA, Ensor J, Dixon K, Feldman A, Appleton-Figueira T, Galloway-Peña J, Hill L, SHELBURNE SA, Tam AL. Oral and gut microbiome temporal variability in hospitalized cancer patients. Keystone Symposium on Microbiome Health and Disease, 2017. e-Pub 2017.
- Mishra NN, Seepersaud R, Tran TT, SHELBURNE SA, Miro JM, Rybak MJ, Arias CA, Sullamm PM, Bayer AS. Phenotypic and genotypic characteristics of in vitro selected high level daptomycin resistant (DAP-R) strains of clinically derived Streptococcus mitis. American Society for Microbiology Microbe, 2017. e-Pub 2017.
- Li X, Numan Y, Kalia A, SHELBURNE SA. Whole genome sequence based identification of a ST-5 sub-cluster of linezolid resistant Staphylococcus epidermidis causing invasive disease in cancer patients. American Society for Microbiology Microbe, 2017. e-Pub 2017.
- Rolston KV, Reitzel R, Vargas-Cruz S, SHELBURNE SA, Raad II, Prince RA. In vitro activity of tedizolid and comparator agents against clinical isolates from cancer patients. American Society for Microbiology Microbe, 2017. e-Pub 2017.
- Galloway-Pena JR, Shah DP, Sahasrabhojane P, Brunlow CE, Carlin LG, Peterson BC, Alousi AM, Shpall EJ, Chemaly RF, Kontoyiannis DP, SHELBURNE SA, Okhuysen PC. Longitudinal fecal microbiome and metabolite analyses identifies potential biomarkers for prediction of graft vs. host disease in hematopoietic stem cell transplant recipients. American Society for Microbiology Microbe, 2017. e-Pub 2017.
- Galloway-Peña J, Smith D, Wadsworth WD, Ajami N, Guindani M, Petrosino J, SHELBURNE SA. The effects of antibiotic exposure on microbiome diversity, microbiome stability, and clinical outcomes during induction remission chemotherapy in acute myeloid leukemia patients. 26th Annual Keck Research Conference Progress and Challenges in Combating Antimicrobial Resistance, 2017. e-Pub 2017.
- Munita J, Sahasrabhojane P, Petitto G, Araos R, Wanger A, Aitken S, SHELBURNE SA Arias CA. Prospective study of enterococcal bacteremia in cancer vs. non-cancer populations: one disease, two tales. Infectious Diseases Society of America Annual Meeting, 2017. e-Pub 2017.
- Argiento R, Guindani M, Vannucci M, Wadsworth D, Galloway-Pena J, Shelburne S. A Bayesian Dirichlet-Multinomial Regression Model for the Analysis of Taxonomic Abundances in Microbiome data. CMStatistics 2016, 2016. e-Pub 2016.
- Muñoz NM, Minhaj AA, Galloway-Peña JR, Melancon MP, Shelburne SA, Tam AL. Irreversible electroporation for control of osteomyelitis caused by Staphylococcus aureus. SIR 2016, 2016. e-Pub 2016.
- DiPippo AJ, Tverdek FP, Tarrand JJ, Munita JM, Tran TT, Arias CA, SHELBURNE SA, Aitken SL. Daptomycin non-susceptible Enterococcus faecium in leukemia patients: Role of prior daptomycin exposure. Infectious Diseases Society of America Annual Meeting, 2016. e-Pub 2016.
- Folan SA, Tverdek F, Tarrand JF, SHELBURNE SA, Raad I, Mulanovich VE, Marx KR, Aitken SL. Empiric linezolid use is associated with adverse short term outcomes in patients with linezolid-resistant Staphylococcus epidermidis bloodstream infections. Infectious Diseases Society of America Annual Meeting, 2016. e-Pub 2016.
- Galloway-Pena, J, Shelburne, SA. Prospective Cohort Study of the Oral and Fecal Microbiome During Induction Remission Chemotherapy in Acute Myelogenous Leukemia. ICAAC/ICC, San Diego, CA, 2015. e-Pub 2015.
- Galloway-Pena, J, Shelburne, SA. Tri-genomic Approach to Investigate Host-Pathogen-Commensal Interaction in a Leukemic Patient with Mucormycosis. ICAAC/ICC 2015-San Diego, CA, 2015. e-Pub 2015.
- PhD JG, PhD DS, Sahasrabhojane P, PhD NA, PhD AF, PhD JP, MD ScD DK, Samuel Shelburne III MD, PhD. Temporal Instability of the Oral and Stool Microbiomes During Induction Chemotherapy for Acute Myeloid Leukemia. Cell-CHIN-Symposium: Human Immunity and the Microbiome in health and Disease 2015, 2015. e-Pub 2015.
- Galloway-Pena, J, Shelburne, SA. First Steps in Analyzing Vaginal Microbiome Data: A Clinically Applied Analysis Discussion. Joint Statistical Meeting 2016, 2015. e-Pub 2015.
- Galloway-Pena, J, Shelburne, SA. Application of a Tri- Genomic Approach to Study Host-Pathogen-Commensal Interaction and Infectious Disease Susceptibility. 1st Place in Clinical Research at the Division of Internal Medicine Research Retreat, 2015. e-Pub 2015.
- Galloway-Pena, J, Shelburne, SA. Monitoring The Microbiome in Leukemia Patients Could Reduce Infections During Chemotherapy. Podcast and live stream internet interview, ASM Live at ICAAC/ICC, 2015. e-Pub 2015.
- Aitken SL, Tarrand JJ, Deshpande LM, Tverdek FP, SHELBURNE SA, Chemaly RF, Prince RA, Rolston KV, Jones RN, Castanheira M. Dissemination of NDM-1 among diverse Enterobacteriaceae in Houston is not related to plasmid-mediated spread. International Congress of Antimicrobial Agents and Chemotherapy, 2015. e-Pub 2015.
- Teatero S, Athey TB, Van Caeseele P, Horsman G, Alexander DC, Melano RG, Li A, Flores AR, SHELBURNE SA, McGeer A, Demczuk W, Martin I, Fittipaldi N. Emergence of serotype IV group B Streptococcus adult invasive disease in Manitoba and Saskatchewan, Canada, is driven by clonal sequence type 459 strains. American Society for Microbiology Annual Meeting, 2015. e-Pub 2015.
- Horstmann N, Saldana M, Sahasrabhojane P, Yao H, Su X, Thompson E, Koller A, Shelburne SA. Regulation of dual-site phosphorylation of response regulator CovR and its impact on group A streptococcus global gene expression and virulence. 8th International Conference on Gram-Positive Microorganisms, Montecatini Terme, 2015. e-Pub 2015.
- Shukla B, SHELBURNE SA, Reyes K, Lewis J, Rincon S, Panesso D, Adachi J, Sifri CD, MD, Zervos M, Munita J, Hasbun R, Arias C. Influence of MIC in clinical outcomes of Enterococcus faecium bacteremia treated with daptomycin: is it time to change the breakpoint?. Infectious Diseases Society of America Annual Meeting, 2015. e-Pub 2015.
- Malik F, Okhuysen P, Alousi A, Shpall E, SHELBURNE SA, Petrosino J, Rezvani K, Ajami NJ, Ghosh N, Carlin L, Chemaly R. Fecal indole correlates with loss of microbiome diversity in hematopoietic stem cell transplant (HSCT) recipients with and without intestinal graft versus host disease (iGVHD). Infectious Diseases Society of America Annual Meeting, 2015. e-Pub 2015.
- Galloway-Peña J, Sahasrabhojane P, Margarit I, Rosini R, Grandi G, McGeer A, Teatero S, Fittipaldi N, Baker C, Shelburne SA, R Flores AA. Small Genetic Changes Drive Phenotypic Diversity Among Sequence Type 1 Group B Streptococcus, An Emerging Cause of Invasive Disease in Adult Humans. IDWeek (IDSA) 2014 in the Immune Response to Microbial Infection Session, 2014. e-Pub 2014.
- Galloway-Pena, J, Shelburne, SA. Elucidation of the Microbiome Landscape of Acute Myelogenous Leukemia Patients Undergoing Induction Remission Chemotherapy. 1st Place in Clinical Research at the Division of Internal Medicine Research Retreat, 2014. e-Pub 2014.
- Galloway-Pena, J, Shelburne, SA. Single Nucleotide Polymorphisms Drive Phenotypic Diversity among Sequence Type 1 Group B Streptococcus, An Emerging Cause Of Invasive Disease In Adult Humans. 2nd Place in Basic Research at the Division of Internal Medicine Research Retreat, 2014. e-Pub 2014.
- Galloway-Pena, J, Shelburne, SA. Analysis of Fluoroquinolone Resistance In Viridans Group Streptococci Causing Invasive Disease in Cancer Patients. Spring 2014 American Society of Microbiology (ASM) Texas Branch Meeting, 2014. e-Pub 2014.
- Galloway-Pena, J, Shelburne, SA. Elucidation of the Changes in the Microbiome and its Role in Septicemia and Neutropenic Fever in Acute Myelogenous Leukemia Patients Undergoing Induction Remission Chemotherapy. Invited oral presentation at the Molecular Basis of Infectious Diseases Conference, 2014. e-Pub 2014.
- Flores AR, Sahasrabhojane P, Saldaña M, Galloway-Peña J, Olsen RJ, Musser JM, A Shelburne AS. Documentation of an Invasive Phenotype of Group A Streptococcus Arising During Human Infection Using Whole Genome Sequencing of Multiple Clinical Isolates From the Same Patient. Symposia on Cancer Research 2013: “Genomic Medicine”, 2013. e-Pub 2013.
- Sahasrabhojane P, MS, Saldaña M, Galloway-Peña J, PhD, Shelburne S, MD, PhD. Novel insights into the emergence of a hypervirulent group A Streptococcus strain revealed by whole genome sequencing of multiple clinical isolates from the same patient. Symposia on Cancer Research 2013, “Genomic Medicine”,, 2013. e-Pub 2013.
- Shelburne SA, Candice W, Catherine M. Improving the Treatment of Staphylococcus aureus bacteremia. University of Texas Clinical Safety and Effectiveness conference in San Antonio, 2013. e-Pub 2013.
- Shelburne S, Sahasrabhojane P, Tarrand J, Rolston K. Development and Validation of a Clinical Model to Predict the Presence of β-lactam Resistance in Viridans Group Streptococci Causing Bacteremia in Neutropenic Cancer Patients. MD Anderson Internal Medicine Research Retreat, 2013. e-Pub 2013.
- SHELBURNE SA, Sahasrabhojane P, Tarrand JJ, Rolston KV. Development and validation of a clinical model to predict the presence of β-lactam resistance in viridans group streptococci causing bacteremia in neutropenic cancer Patients. MD Anderson Internal Medicine Research Retreat, 2013. e-Pub 2013.
- Torres HA, Rallapalli V, Saxena A, Granwehr B, Viola G, Ariza E, Marfatia R, Jiang Y, Adachi J, Chemaly R, SHELBURNE SA, Mulanovich V. Efficacy and safety of antiretovirals in HIV-infected patients with cancer. International Congress of Antimicrobial Agents and Chemotherapy, 2013. e-Pub 2013.
- Shelburne S, Sahasrobhojane P, Tarrand J, Yao H. Identification and Characterization of Streptococcus mitis Strains Causing Severe Clinical Disease in Cancer Patients. MD Anderson Internal Medicine Research Retreat, 2013. e-Pub 2013.
- Shelburne SA, Sahasrobhojane P, Saldana M. Identification and Genome-Level Characterization of Highly Virulent Viridians Group Streptococci Causing Invasive Disease in Patients with Malignancy. Infectious Diseases Society of America 2012. San Diego CA, 2012. e-Pub 2012.
- Shelburne SA, Tarrand J, Rolston K. Epidemiology, Treatment, and Outcomes of Viridans Group Streptococcal Bloodstream Infections in the Era of High Rates of Antimicrobial Prophylaxis and Empiric Vancomycin Use. Infectious Diseases Society of America 2012, San Diego CA, 2012. e-Pub 2012.
- Shelburne SA, Tarrand J, Rolston K. Invasive Streptococcal Infections at a United States Cancer Center 2000-2011. Infectious Diseases Society of America 2012. San Diego CA, 2012. e-Pub 2012.
- Shelburne SA, Tarrand J. Viridans Group Streptococcal Bloodstream and Alpha Streptococcal Shock Syndrome Rates are Increasing in the Era of Antimicrobial Prophylaxis. MD Anderson Internal Medicine Research Retreat, 2012. e-Pub 2012.
- Lin E, Bhusal Y, Horwitz D, SHELBURNE SA, Trautner B. Enterococcal bacteriuria is often overtreated and rarely leads to infectious complications. Infectious Diseases Society of America Annual Meeting, 2011. e-Pub 2011.
- Shelburne SA, Carroll RK, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. Program and abstracts of the American Society for Clinical Investigation/Association of American Physicians Joint Meeting, Chicago, IL and The MDACC Department of Internal Medicine Research Retreat, 2011. e-Pub 2011.
- Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen RJ, Flores A, Musser JM, Brennan RG, Shelburne SA. Distinct single amino Acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. International Congress of Antimicrobial Agents and Chemotherapy, Chicago, IL, 2011. e-Pub 2011.
- Lin E, Horwitz D, Bhusal Y, Roig I, SHELBURNE SA, Trautner B. Enterococcal Bacteriuria Is Often Managed Inappropriately. Infectious Diseases Society of America Annual Meeting, 2010. e-Pub 2010.
- Lin E, Horowitz D, Bhusal Y, Roig I, Shelburne SA, Trautner B. Asymptomatic enterococcal bacteruria has a low rate of infectious complications. Program and abstracts of the 48th Annual IDSA Meeting, Vancouver, BC, 2010. e-Pub 2010.
- Shelburne SA, Suber B, Sahasrobhojane P. A MalR-regulated protein that binds linear glucose polymers is critical to streptococcal oropharyngeal adherence. MDACC Department of Internal Medicine Research Retreat, 2010. e-Pub 2010.
- Shelburne SA, Olsen RJ, Brennan RG, Musser JM. Identification of the molecular mechanism by which CcpA contributes to the pathogenesis of streptococcal infection. Program and abstracts of the American Society for Clinical Investigation/Association of American Physicians Joint Meeting, Chicago, IL, 2009. e-Pub 2009.
- SHELBURNE SA, Horstmann N, Brennan RG, and Musser JM. Interaction between transcriptional regulatory proteins contributes to the pathogenesis of invasive group A streptococcal disease. Program and abstracts of the American Society for Clinical Investigation/Association of American Physicians Joint Meeting, 2009. e-Pub 2009.
- Shelburne SA, Keith D, Davenport M, Musser JM. Role of extracellular polysaccharide degrading enzymes in group A streptococcal pathogenesis. Program and abstracts of the 2008 IDSA/ICAAC Joint Meeting, Washington, DC. (poster presentation), 2008. e-Pub 2008.
- Shelburne SA, Keith D, Horstaman N, Sumby P, Davenport M, Graviss EA, Brennan RG, Musser JM. A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. Program and abstracts of the American Society for Clinical Investigation/Association of American Physicians Joint Meeting, Chicago, IL, 2008. e-Pub 2008.
- Shelburne SA, Keith DB, Sumby P, Fang H, Sitkiewicz I, Austin CM, Graviss EA, Chow DC, Musser JM. Group A Streptococcus uses human salivary α-amylase to catabolize glucans. Program and abstracts of the American Society for Clinical Investigation/Association of American Physicians Joint Meeting, Chicago, IL, 2007. e-Pub 2007.
- Shelburne SA, Sumby P, Sitkiewicz I, Okorafor N, Granville G, Patel P, Voyich J, Hull R, DeLeo FR, Musser JM. Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx. Program and abstracts of the 44th Annual IDSA Meeting, Toronto, ON, (oral presentation), 2006. e-Pub 2006.
- Daver NG, Shelburne SA, Atmar R, Giordano T, Reitman C, Jr WA. IV to oral step-down therapy comparable to parenteral therapy for staphylococcal osteomyelitis. Program and abstracts of the 43rd Annual IDSA Meeting, San Francisco, CA,, 2005. e-Pub 2005.
- Sutarwala A, Rueda A, Shelburne SA. Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureus. Programs and abstracts of the 43rd Annual IDSA meeting, San Francisco, CA,, 2005. e-Pub 2005.
- Shelburne SA, Granville C, Tokuyama M, Sitkiewicz I, Patel P, Musser JM. Growth characteristics and virulence factor production by group A Streptococcus during cultivation in human saliva. Program and abstracts of the 43rd Annual IDSA Meeting, San Francisco, CA,, 2005. e-Pub 2005.
- Shelburne SA, Darcourt J, White AC, Greenberg S, Hamill RJ, Atmar R, Visnegarwala F. Incidence and risk factors for immune reconstitution inflammatory syndrome (IRIS) among patients with Cryptococcus neoformans infection. Program and abstracts of the 11th Annual Conference on Retroviruses and Opportunistic Infections, San Francisco, CA,, 2004. e-Pub 2004.
- SHELBURNE SA, Giordano TP, Visnegarwala F, Graviss EA, Darcourt J, Hamill RJ, White AC. Prevalence of immune reconstitution inflammatory syndrome (IRIS) during highly active antiretroviral therapy (HAART) in HIV-infected patients with Mycobacterium tuberculosis (MTB), Mycobacterium avium complex (MAC), or Cryptococcus neoformans infection. Infectious Diseases Society of America Annual Meeting, 2003. e-Pub 2003.
- Shelburne SA, Darcourt J, Visnegarwala F, Giordano T, Graviss E, Hamill RJ. Incidence and risk factors for immune reconstitution inflammatory syndrome in HIV-infected patients infected with Mycobacterium tuberculosis, Mycobacterium avium complex, or Cryptococcus neoformans who are treated with highly active antiretroviral therapy. Program and abstracts of the 41st Annual IDSA Meeting, San Diego, CA,, 2003. e-Pub 2003.
- Shelburne SA, Hamill RJ, Rodriguez-Barradas MC, Greenberg SB, Gathe JC, Trautner B, Visnegarwala F, Atmar RL. Immune reconstitution inflammatory syndrome (IRIS): emergence of unique syndrome during highly active antiretroviral therapy (HAART). 39th Annual IDSA Meeting, San Francisco, CA,, 2001. e-Pub 2001.
- Le M, Shelburne SA. Population-Structure-Aware SNP Threshold Derivation Improves Outbreak Resolution in Escherichia coli. International Society for Computational Biology.
Book Chapters
- Shelburne SA, Hamill RJ. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment, 2018.
- Shelburne SA, Lewis RE, Kontoyiannis D. Clinical Approach To Infections in the Compromised Host. In: Hematology, Basic Principles And Practice, Sixth, 2017.
- Shelburne SA, Hamill RJ. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment, 2017.
- Shelburne SA, Hamill RJ. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment, 2016.
- Shelburne SA, Hamill RJ. Infectious Disease: Mycotic. In: Medical Diagnosis and Treatment, 2015.
- Shelburne SA, Hamill RJ. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment, 2014.
- Shelburne SA, Hamill RJ. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment, 2013.
- Shelburne SA, Hamill RJ. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment, 2012.
- Shelburne SA, Lewis RE, Kontoyiannis D. Clinical Approach To Infectious In The Compromised Hose. In: Hematology, Basic Principles and Practice, Sixth, 2012.
- Shelburne SA, Hamill RJ. Infectious Diseases: Mycrotic. In: Medical Diagnosis and Treatment. Appleton & Lange, 2011.
- Shelburne SA, Musher DM. Management of Gram-Positive Bacterial Disease: Staphylococcus aureus, Streptococcal, Pneumococcal and Enterococcal Infections. In: Principles and Practice of Cancer Infectious Diseases. 409. Humana Press, 2011.
- Shelburne SA, Hamill RJ. Infectious Disease: Mycotic. In: Medical Diagnosis and Treatment. Appleton & Lange, 2010.
- Shelburne SA, Hamill RJ. Infectious Disease: Mycotic. In: Medical Diagnosis and Treatment. Appleton & Lange, 2009.
- Shelburne SA. Empirical use of Fluconazole in critically ill patients: good study but was the hold-up?. In: Annals of Internal Medicine. 150, 58-59, 2009.
- Shelburne SA, Hamill RJ. Infectious Disease: Mycotic. In: Medical Diagnosis and Treatment. LM Tierney, Jr, SJ McPhee, MA Papadakis, 2008.
- Shelburne SA. Immune reconstitution inflammatory syndrome. In: Clinical Infectious Diseases. Cambridge University Press, 2008.
- Hamill RJ, Shelburne SA. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment. Appleton & Lange, 2007.
- Hamill RJ, Shelburne SA. Infectious Diseases: Mycotic. In: Medical Diagnosis and Treatment. Appleton & Lange, 2006.
- Hamill RJ, Shelburne SA. Infectious Diseases. In: Medical Secrets. 4. Hanley & Belfus, Inc, 2005.
- Shelburne SA, Shandera WX. Infectious Disease: Vurak & rickettsial. In: Medical Diagnosis and Treatment. Appleton & Lange, 2004.
- Shelburne SA, Shadera WX. Infectious Diseases: Viral & rickettsial. In: Medical Diagnosis and Treatment. Appleton & Lange, 2003.
Letters to the Editor
- Shelburne SA. Empirical use of fluconazole in critically ill patients: good study, but what was the hold-up?. Ann Intern Med 150: 58-9; author reply 59-60, 2009.
Patient Reviews
CV information above last modified August 14, 2026