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S. Cheenu Kappadath, Ph.D.

Department of Imaging Physics, Division of Diagnostic Imaging

About Dr. S. Cheenu Kappadath

S. Cheenu Kappadath, Ph.D., is a Professor in the Department of Imaging Physics. He is a board-certified and licensed medical physicist with specialties in Nuclear Medicine Physics and Instrumentation (ABSNM) and Diagnostic Radiologic Physics (ABR). He provides clinical physics support for the Departments of Nuclear Medicine and Diagnostic Radiology in the Division of Diagnostic Imaging. He is the Program Director for Imaging Physics Network Services and oversees clinical Imaging Physics operations at institutions within the MD Anderson Cancer Network as well as other satellite and regional care facilities.

He is actively involved in a variety of funded research projects in SPECT/CT, PET/CT, and CT and is the recipient of grants from NIH and industry. Topics of research focus include liver-directed Yttrium-90 microsphere therapy, molecular breast imaging, quantitative imaging with SPECT, PET, and CT; and patient-specific voxel dosimetry. Dr. Kappadath also holds a joint Associate Faculty appointment at The University of Texas Graduate School of Biomedical Sciences in Houston where he serves as an instructor in various courses and advisor to medical physics graduate students. Dr. Kappadath is an active member of several professional medical physics societies such as the AAPM, SNMMI, and ACR. More recently, his research has received the Arthur Weis Award in Radiation Dosimetry and Safety from the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

Primary Appointment

Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Faculty, Image Guided Cancer Therapy (IGCT) Program, The University of Texas MD Anderson Cancer Center, Houston, TX

Faculty, Cancer Core Support Grant - Radiation Oncology Cancer Imaging (ROCIP) Program, The University of Texas MD Anderson Cancer Center, Houston, TX

Faculty, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX

Research Interests

His research interests are focused on Nuclear Medicine physics with specific emphasis on developing quantitative imaging to aid in the diagnosis and managements of cancer patients. Areas of specialization include:

· Liver-directed Yttrium-90 microsphere therapy

· Molecular breast imaging (MBI)

· Quantitative imaging with SPECT/CT, PET/CT, and DE-CT

· Novel algorithms for patient-specific voxel dosimetry

A strong interest lies in improving all aspects of liver-directed Yttrium-90 microsphere therapy from improving patient imaging for therapy planning to quantifying post-therapy imaging to measure tumor dose and evaluate response. His research lab is looking at novel algorithms for patient-specific voxel dosimetry and its application to determine the tumor dose-response and toxicities following Yttrium-90 microsphere therapy. Research is also conducted in quantifying radionuclide uptake in breast cancers with MBI and assessing its capability as an indicator to tumor response following chemotherapy.

Clinical Interests

· Work with radiologists to improve diagnostic image quality for routine clinical imaging

· Clinical implementation of innovations in data acquisition and image generation

· Manage clinical imaging physics activities at Partner Institutions and Regional Care Centers

Education & Training

Degree-Granting Education

1998	University of New Hampshire, Durham, New Hampshire, US, Physics, Ph.D
1994	University of New Hampshire, Durham, New Hampshire, US, Physics, M.S
1991	Illinois Wesleyan University, Bloomington, Illinois, US, Physics and Mathematics, BA

Postgraduate Training

2006-2007	Clinical Residency, Medical Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas
1998-2001	Postdoctoral Research Scientist, Physics and Astronomy, Louisiana State University, Baton Rouge, Louisiana

Board Certifications

2008	American Board of Radiology, Diagnostic Medical Physics
2007	American Board of Science in Nuclear Medicine, Nuclear Medicine Physics and Instrumentation

Experience & Service

Academic Appointments

Associate Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2021

Assistant Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2014

Instructor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2003 - 2005

Research Associate, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2001 - 2003

Postdoctoral Research Scientist, Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, 1998 - 2001

Graduate Research Assistant, Department of Imaging Physics, The University of New Hampshire, Durham, NH, 1991 - 1998

Administrative Appointments/Responsibilities

Clinical Coordinator, Nuclear Medicine Physics, Imaging Physics Residency Program, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present

Member, Merit and FRP Committee, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present

Program Director, Imaging Physics Network Services, Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - Present

Member, Imaging Physics Clinical Operations Committee, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2015

Member, Nuclear Medicine Research Peer-Review Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - Present

Other Appointments/Responsibilities

Coordinator, Outreach Clinical Physics Operations, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2015

Clinical Consultant, MD Anderson Cancer Network, Houston, TX, 2011 - Present

Lead Imaging Physicist, Banner MD Anderson Cancer Center, Phoenix, AZ, 2011 - 2013

Institutional Committee Activities

Member, Institutional Review Board (IRB), 2023 - Present

Member, Faculty Academic Review Committee (FARC), 2015 - 2018

Departmental Representative, Faculty Appeals Committee (FAC), 2014 - 2018

Honors & Awards

2024	AAPM Travel Award, Global Research and Education Mentoring Program, American Association for Physicists in Medicine
2023	Clinical Research Award, Division of Diagnostic Imaging, UT MD Anderson Cancer Center
2023	Best in Physics Award (Imaging), Lopez BL, Rauch GM, Kappadath SC. Absolute 99mTc-Sestamibi Breast Uptake in HER2-, HER2+, and TNBC Patients Undergoing Neoadjuvant Chemotherapy, American Association of Physicists in Medicine (AAPM) Annual Meeting
2023	Best Presentation at GEST – 3rd Place, Radioembolization for HCC patients with personalized Yttrium-90 dosimetry for curative intent (RAPY90D), Mahvash A, Henry C, Lopez B, Abdelsalam M, Chasen B, Kuban J, Metwalli Z, Odisio B, Habibollahi P, Murthy R, Kaseb A, Kappadath SC, Global Embolization Symposium and Technologies (GEST) Annual Meeting
2023	AAPM Mentor Award, Global Research and Education Mentoring Program, American Association for Physicists in Medicine (AAPM)
2023	Top 2022 Scientific Paper Award in EJNMMI Physics, Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model – Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon AC, Bryan JN, Maitz C, Abraham R, Kappadath SC, Syme A, European Journal of Nuclear Medicine and Molecular Imaging Physics
2022	Best in Physics Award (Therapy), Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon A, Bryan J, Maitz C, Abraham R, Kappadath SC, Syme A. Precision Dosimetry in Yttrium-90 Radioembolization Through CT Imaging of Radiopaque Microspheres in a Rabbit Liver Model, American Association for Physicists in Medicine (AAPM) Annual Meeting
2019 - 2022	Multi-Year Clinical Faculty Appointment Award, UT MD Anderson Cancer Center
2019	Fellow, American Association for Physicists in Medicine
2019	President’s Recognition of Faculty Excellence Award, UT MD Anderson Cancer Center
2018	1st Place Award Data Science and Instrumentation Track Poster Award, Lopez B, Balagopal A, Mahvash A, Kappadath SC. Evaluation of Errors in Common Lung Mass Estimation Methods used for Lung Mean Dose (LMD) Calculation in 90Y-Microsphere Therapy Planning, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2018	Finalist, Young Investigator Symposium, Lopez B, Mahvash A, Kappadath SC. Novel SPECT/CT-Based Lung Dose Calculation for Treatment Planning in 90Y-Microsphere Radioembolization Therapy, American Association for Physicists in Medicine (AAPM) Annual Meeting
2016	Aaron Blanchard Research Award for best dissertation in Medical Physics by mentee Justin Mikell, Voxel-level absorbed dose calculations with a deterministic grid-based Boltzmann solver for nuclear medicine and the clinical value of voxel-level calculations, UT Health Graduate School of Biomedical Sciences MD Anderson Cancer Center, Houston, Texas
2015	Arthur Weis Award in Radiation Dosimetry and Safety, Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Biases and variability in partition model absorbed doses following Y90 microsphere therapy, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2015	3rd Place Award Oncology Clinical Diagnosis Track Poster Presentation, Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Biases and variability in partition model absorbed doses following Y90 microsphere therapy, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2014	Volunteer Service Award, American Board of Radiology
2012	2nd Place Award Radiopharmacy Track Poster Presentation, Maclellan C, Hobbs BP, Chasen B, Murthy R, Mahvash A, Kappadath SC. Absorbed dose differences in 90Y microsphere therapy between pre-treatment 99mTc-MAA and post-treatment 90Y scans, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2012	2nd Place Award Technologist Oral Presentation, Gonzalez JA, McCoy AP, Mar MV, Kappadath SC. Identifying optimal SPECT acquisition for liver imaging using 99mTc-MAA, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2012	2nd Place Molecular Targeting Probes Track Poster Award, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting
2008	American Board of Radiology Certification in Diagnostic Radiologic Physics
2007	American Board of Science in Nuclear Medicine Certification in Nuclear Medicine Physics and Instrumentation
2007	Reviewer's Choice Oral Presentation Award, Kappadath SC, Wendt RE. Assessment of the radiation shielding for a busy PET/CT facility, American Association for Physicists in Medicine (AAPM) Annual Meeting
2007	Trainee Travel Grant Recipient, IEEE Medical Imaging Annual Conference, Honolulu, Hawaii
2006 - 2008	Medical Physics Residency Award, Radiological Society of North America
2004	Honorable Mention Poster Award, Kappadath SC, Shaw C, Lai CJ, Liu X, Whitman G., Dual-energy digital mammography for calcification imaging: theory and implementation, SPIE Physics of Medical Imaging Symposium
1991	Cum laude, B.A, Illinois Wesleyan University, Bloomington, Illinois
1991	Meritorious Award, Mathematical Contest in Modeling, Illinois Wesleyan University, Bloomington, Illinois
1987 - 1991	Scholarship Award, Illinois Wesleyan University, Bloomington, Illinois

Professional Memberships

American Association of Physicists in Medicine (AAPM)

2024 - Present

Nuclear Medicine Technologist Certification Board (NMTCB)

2021 - 2024

NRG Oncology

2019 - Present

The European Association of Nuclear Medicine (EANM)

2014 - Present

The American College of Radiology (ACR)

2013 - Present

MD Anderson Cancer Center UT Health, Graduate School for Biomedical Sciences

2013 - 2019

The American Board of Radiology (ABR)

2010 - Present

MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences

2008 - Present

American College of Medical Physics (ACMP)

2008 - 2012

The Society of Nuclear Medicine and Molecular Imaging (SNMMI)

2008 - Present

The International Society for Optical Engineering (SPIE)

2003 - 2012

American Association of Physicists in Medicine (AAPM)

2002 - Present

Selected Publications

Peer-Reviewed Articles

Lam, MG, Garin, E, Haste, P, Denys, A, Geller, BS, Kappadath, SC, Turkmen, C, Sze, DY, Alsuhaibani, H, Herrmann, K, MacCauro, M, Cantasdemir, M, Dreher, MR, Fowers, K, Gates, VL, Salem, R. Utility of pre-procedural [99mTc]TcMAA SPECT/CT Multicompartment Dosimetry for Treatment Planning of 90Y Glass microspheres in patients with Hepatocellular Carcinoma. European Journal of Nuclear Medicine and Molecular Imaging 52(2):744-755, 2025. e-Pub 2025. PMID: 39331131.
Abraham RJ, Arepally A, Liu D, Lewandowski R, Kappadath SC, Verma A, Dobrowski D, Holden A. Imageable Radioembolization Microspheres for Treatment of Unresectable Hepatocellular Carcinoma: Interim Results from a First-in-Human Trial. J Vasc Interv Radiol 35(10):1464-1473.e1, 2024. e-Pub 2024. PMID: 38944236.
Gonzalez F, Scott PJH, Jeffers CD, Kappadath SC. SNMMI Clinical Trials Network Research Series for Technologists: An Introduction to Conducting Theranostic Clinical Trials. J Nucl Med Technol 52(3):184-191, 2024. e-Pub 2024. PMID: 39237336.
Lopez BP, Kappadath SC. (90)Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit. J Nucl Med Technol 52(3):256-260, 2024. e-Pub 2024. PMID: 39019573.
Kappadath SC, Henry EC, Lopez BP, Mahvash A. Quantitative evaluation of (90)Y-PET/CT and (90)Y-SPECT/CT-based dosimetry following Yttrium-90 radioembolization. Med Phys 51(9):6061-6074, 2024. e-Pub 2024. PMID: 38781554.
Henry EC, Mahvash A, Lopez BP, Kappadath SC. A comparison of methods for in vivo activity and absorbed dose quantification with PET/CT following yttrium-90 radioembolization. Med Phys 51(9):6034-6045, 2024. e-Pub 2024. PMID: 38772046.
Kokabi N, Webster LA, Dabbous H, Shah A, Brandon D, Galt J, Xing M, Villalobos A, Davarpanahfakhr A, Kappadath SC, Schuster DM. Resin-Based 90 Y Tumor Dose as a Predictor of Duration of Response and Survival in Patients With Surgically Unresectable Hepatocellular Carcinoma : A Prospective Single-Arm Study. Clin Nucl Med 49(9):799-805, 2024. e-Pub 2024. PMID: 38861361.
Lam MGEH, Kappadath SC. Need for a Practical Dosimetry Paradigm That Incorporates Dose Heterogeneity. J Vasc Interv Radiol 35(6):919-921, 2024. e-Pub 2024. PMID: 38432473.
Keane G, van Rooij R, Lam M, Kappadath SC, Kovan B, Leon S, Dreher M, Fowers K, de Jong H. An international phantom study of inter-site variability in Technetium-99m image quantification: analyses from the TARGET radioembolization study. EJNMMI Phys 11(1):46, 2024. e-Pub 2024. PMID: 38809320.
Kappadath SC. Retrospective dosimetry for yttrium-90 radioembolization with resin microspheres. J Vasc interv Radiol 35(5):709-711, doi:10.1016/j.jvir.2024.01.013, 2024. e-Pub 2024.
Henry EC, Lopez B, Mahvash A, Thomas MA, Kappadath SC. Predicting the net administered activity in 90 Y-radioembolization patients from post-procedure 90 Y-SPECT/CT. Med Phys 50(11):7003-7015, 2023. e-Pub 2023. PMID: 37272198.
Lopez BP, Kappadath SC. Monte Carlo-derived 99m Tc uptake quantification with commercial planar MBI: Tumor and breast activity concentrations. Med Phys 50(5):2985-2997, 2023. e-Pub 2023. PMID: 36625713.
Lopez BP, Kappadath SC. Monte Carlo-derived 99m Tc uptake quantification with commercial planar MBI: Absolute tumor activity. Med Phys 50(5):2985-2997, 2023. e-Pub 2023. PMID: 36583691.
Kappadath SC, Lopez BP. Single-Compartment Dose Prescriptions for Ablative 90Y-Radioembolization Segmentectomy. Life (Basel) 13(6), 2023. e-Pub 2023. PMID: 37374021.
Kokabi N, Arndt-Webster L, Chen B, Brandon D, Sethi I, Davarpanahfakhr A, Galt J, Elsayed M, Bercu Z, Cristescu M, Kappadath SC, Schuster DM. Voxel-based dosimetry predicting treatment response and related toxicity in HCC patients treated with resin-based Y90 radioembolization: a prospective, single-arm study. Eur J Nucl Med Mol Imaging 50(6):1743-1752, 2023. e-Pub 2023. PMID: 36650357.
Salem R, Padia SA, Lam M, Chiesa C, Haste P, Sangro B, Toskich B, Fowers K, Herman JM, Kappadath SC, Leung T, Sze DY, Kim E, Garin E. Clinical, dosimetric, and reporting considerations for Y-90 glass microspheres in hepatocellular carcinoma: updated 2022 recommendations from an international multidisciplinary working group. Eur J Nucl Med Mol Imaging 50(2):328-343, 2023. e-Pub 2023. PMID: 36114872.
Lam M, Garin E, Palard-Novello X, Mahvash A, Kappadath SC, Haste P, Tann M, Herrmann K, Barbato F, Geller B, Schaefer N, Denys A, Dreher M, Fowers KD, Gates V, Salem R. Direct comparison and reproducibility of two segmentation methods for multicompartment dosimetry: round robin study on radioembolization treatment planning in hepatocellular carcinoma. Eur J Nucl Med Mol Imaging 51(1):245-257, 2023. e-Pub 2023. PMID: 37698645.
Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon AC, Bryan JN, Maitz C, Karnia JJ, Abraham R, Kappadath SC, Syme A. Correction: Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model. EJNMMI Phys 10(1):74, 2023. e-Pub 2023. PMID: 38017227.
Kokabi N, Webster LA, Elsayed M, Switchenko JM, Chen B, Brandon D, Galt J, Sethi I, Cristescu M, Kappadath SC, Schuster DM. Accuracy and Safety of Scout Dose Resin Yttrium-90 Microspheres for Radioembolization Therapy Treatment Planning: A Prospective Single-Arm Clinical Trial. J Vasc Interv Radiol 33(12):1578-1587.e5, 2022. e-Pub 2022. PMID: 36075560.
Lopez BP, Mahvash A, Long JP, MGEH L, Kappadath SC. Factors modulating 99mTc-MAA planar lung dosimetry for 90Y-radioembolization. J Appl Clin Med Phys 23(12):e13734, 2022. e-Pub 2022. PMID: 35906892.
Hruska, CB, Corion, C, de Geus-Oei, LF, Adrada, BE, Fowler, AM, Hunt, KN, Kappadath, SC, Pilkington, P, Pereira Arias-Bouda, LM, Rauch, GM. SNMMI Procedure Standard/EANM Practice Guideline for Molecular Breast Imaging with Dedicated g-Cameras. Journal of nuclear medicine technology 50(2):103-110, 2022. e-Pub 2022. PMID: 40168518.
Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon AC, Bryan JN, Maitz C, Abraham R, Kappadath SC, Syme A. Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model. EJNMMI Phys 9(1):21, 2022. e-Pub 2022. PMID: 35312882.
Lopez BP, Rauch GM, Adrada B, Kappadath SC. Functional tumor diameter measurement with molecular breast imaging: development and clinical application. Biomed Phys Eng Express 8(5), 2022. e-Pub 2022. PMID: 35917778.
Kappadath SC, Lopez BP. Organ-level internal dosimetry for intra-hepatic-arterial administration of 99mTc-macroaggregated albumin. Med Phys 49(8):5504-5512, 2022. e-Pub 2022. PMID: 35612924.
Hruska CB, Corion C, de Geus-Oei LF, Adrada BE, Fowler AM, Hunt KN, Kappadath SC, Pilkington P, Arias-Bouda LMP, Rauch GM. SNMMI procedure standard/EANM practice guideline for molecular breast imaging with dedicated gamma cameras. J Nucl Med Technol 50(2):103-110, 2022. e-Pub 2022.
Mahvash A, Chartier S, Turco M, Habib P, Griffith S, Brown S, Kappadath SC. A prospective, multicenter, open-label, single-arm clinical trial design to evaluate the safety and efficacy of 90Y resin microspheres for the treatment of unresectable HCC: the DOORwaY90 (Duration Of Objective Response with arterial Ytrrium-90) study. BMC Gastroenterol 22(1):151, 2022. e-Pub 2022. PMID: 35346070.
Kairemo K, Kangasmäki A, Kappadath SC, Joensuu T, Macapinlac HA. A retrospective comparative study of sodium fluoride Na18F-PET/CT and 68Ga-PSMA-11 PET/CT in the bone metastases of prostate cancer using a volumetric 3-D radiomic analysis. Life 12(12):1977, 2022. e-Pub 2022. PMID: 36556342.
Sharma NK, Kappadath SC, Chuong M, Folkert M, Gibbs P, Jabbour SK, Jeyarajah DR, Kennedy A, Liu D, Meyer JE, Mikell J, Patel RS, Yang G, Mourtada F. The American Brachytherapy Society consensus statement for permanent implant brachytherapy using Yttrium-90 microsphere radioembolization for liver tumors. Brachytherapy 21(5):569-591, 2022. e-Pub 2022. PMID: 35599080.
Broyles JM, Smith JM, Wong FC, Hanasono MM, El C, Kappadath SC, Schaverien MV. Single-photon emission computed tomographic reverse lymphatic mapping for groin vascularized lymph node transplant planning. Plast Reconstr Surg 150(4):869e-879e, 2022. e-Pub 2022. PMID: 35939631.
Lam M, Garin E, Maccauro M, Kappadath SC, Sze DY, Turkmen C, Cantasdemir M, Haste P, Herrmann K, Alsuhaibani HS, Dreher M, Fowers KD, Salem R. A global evaluation of advanced dosimetry in transarterial radioembolization of hepatocellular carcinoma with Yttrium-90: the TARGET study. Eur J Nucl Med Mol Imaging 49(10):3340-3352, 2022. e-Pub 2022. PMID: 35394152.
Teyateeti, A, Mahvash, A, Long, JP, Abdelsalam, ME, Avritscher, R, Kaseb, A, Odisio, BC, Ravizzini, G, Surasi, DS, Teyateeti, A, Macapinlac, HA, Kappadath, SC. Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib. World journal of gastroenterology 27(47):8166-8181, 2021. e-Pub 2021. PMID: 35068861.
Kairemo, K, Jessop, A, Vija, A, Ding, X, Spence, D, Kappadath, SC, Macapinlac, HA. A prospective comparative study of using ultrasonography, 4d-ct and parathyroid dual-phase scintigraphy with spect in patients with primary hyperparathyroidism. Diagnostics 11(11), 2021. e-Pub 2021. PMID: 34829354.
Lopez, BP, Guan, F, Rauch, GM, Kappadath, SC. Monte Carlo simulation of pixelated CZT detector with Geant4. Physics in medicine and biology 66(12), 2021. e-Pub 2021. PMID: 34038878.
Henry, EC, Strugari, M, Mawko, G, Brewer, KD, Abraham, R, Kappadath, SC, Syme, A. Post-administration dosimetry in yttrium-90 radioembolization through micro-CT imaging of radiopaque microspheres in a porcine renal model. Physics in medicine and biology 66(9), 2021. e-Pub 2021. PMID: 33784639.
Levillain, H, Bagni, O, Deroose, CM, Dieudonné, A, Gnesin, S, Großer, OS, Kappadath, SC, Kennedy, A, Kokabi, N, Liu, D, Madoff, DC, Mahvash, A, Martinez de la Cuesta, A, Ng, DC, Paprottka, PM, Pettinato, C, Rodriguez-Fraile, M, Salem, R, Sangro, B, Strigari, L, Sze, DY, de Wit van der veen, BJ, Flamen, P. International recommendations for personalized selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres. European Journal of Nuclear Medicine and Molecular Imaging 48(5):1570-1584, 2021. e-Pub 2021. PMID: 33433699.
Kappadath, SC, Lopez, BP, Salem, R, Lam, MG. lung shunt and lung dose calculation methods for radioembolization treatment planning. Quarterly Journal of Nuclear Medicine and Molecular Imaging 65(1):32-42, 2021. e-Pub 2021. PMID: 33393753.
Kairemo K, Jessop AC, Vija AH, Ding X, Spence D, Kappadath SC, Macapinlac HA. A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism. Diagnostics 11(11):2006, 2021. e-Pub 2021.
Henry EC, Strugari M, Mawko G, Brewer KD, Abraham R, Kappadath SC, Syme A. Post-administration dosimetry in yttrium-90 radioembolization through micro-CT imaging of radiopaque microspheres in a porcine renal model. Phys Med Biol 66:095011, 2021. e-Pub 2021.
Lopez BP, Guan F, Rauch GM, Kappadath SC. Monte Carlo simulation of pixelated CZT detector with Geant4: validation of clinical molecular breast imaging system. Phys Med Biol 66:125009, 2021. e-Pub 2021.
Kappadath SC, Lopez BP, Salem R, MGEH L. Reassessment of the lung dose limits for radioembolization. Nucl Med Comm 42:1064–1075, 2021. e-Pub 2021.
Teyatteti A, Mahvash A, Long J, Abdelsalam M, Avritscher R, Kaseb A, Odisio B, Ravizzini G, Surasi D, Teyatteti A, Macapinlac H, Kappadath SC. Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib. World J Gastroenterol 27(47):8166-8181, 2021. e-Pub 2021.
Kappadath SC, Lopez BP, Salem R, MGEH L. Lung shunt and lung dose calculation methods for radioembolization treatment planning. Q J Nucl Med Mol Imaging 65(1):32-42, 2021. e-Pub 2021.
Levillain H, Bagni O, Deroose CM, Dieudonne A, Gnessin S, Grosser OS, Kappadath SC, Kennedy A, Kokabi N, Liu DM, Madoff DC, Mahvash A, Martinez A, Ng D, Paprottka P, Pettinato C, Rodríguez-Fraile M, Salem R, Sangro B, Strigari L, Sze DY, de Wit B, Flamer P. International recommendations for personalized selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres. Eur J Nucl Med Mol Imaging 48:1570–1584, 2021. e-Pub 2021.
Kairemo K, Kappadath SC, Joensuu T, Macapinlac HA. A Retrospective Comparative Study of Sodium Fluoride (NaF-18)-PET/CT and Fluorocholine (F-18-CH) PET/CT in the Evaluation of Skeletal Metastases in Metastatic Prostate Cancer Using a Volumetric 3-D Radiomics Analysis. Diagnostics (Basel) 11(1):17, 2021. e-Pub 2021. PMID: 33374148.
Kaseb AO, Kappadath SC, Lee SS, Raghav KP, Mohamed YI, Xiao L, Morris JS, Ohaji C, Avritscher R, Odisio BC, Kuban J, Abdelsalam ME, Chasen B, Elsayes KM, Elbanan M, Wolff RA, Yao JC, Mahvash A. A prospective phase II study of safety and efficacy of sorafenib followed by 90Y glass microspheres for patients with advanced or metastatic hepatocellular carcinoma. J Hepatocell Carcinoma 8:1129-1145, 2021. e-Pub 2021.
Popnoe DO, Chaan NS, Zhou S, Kaur H, Kang HC, Loyer EM, Kappadath SC, Jones AK. Comparison of virtual to true unenhanced abdominal computed tomography images acquired using rapid kV-switching dual energy imaging. PLOS One 15(9), 2020. e-Pub 2020.
Adrada, B, Moseley T, Kappadath SC, Whitman, GJ, Rauch GM. Molecular Breast Imaging guided percutaneous biopsy of breast lesions: a new frontier on breast interventions. J of Breast Imaging 2(5):484-491, doi:10.1093/jbi/wbaa057, 2020. e-Pub 2020.
AJAT B, Ahmadzadehfar H, Kappadath SC, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, MGEH L. Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy. Cardiovasc Intervent Radiol 43(2):246-253, doi: 10.1007/s00270-019-02350-2, 2020. e-Pub 2020. PMID: 31646375.
Thomas MA, Mahvash A, Abdelsalam M, Kaseb AO, Kappadath SC. Planning dosimetry for 90Y radioembolization with glass microspheres: evaluating the fidelity of 99mTc-MAA and partition model predictions. Med Phys 47(10):5333-5342, doi:10.1002/mp.14452, 2020. e-Pub 2020.
Abdelsalam M, Kappadath SC, Mahvash A. Blood flow diversion using the micro-vascular plug to avoid non target delivery of radioactive microspheres. Radiol Case Rep. 15, 2015-2017 15(1), 2020. e-Pub 2020.
Teyatteti A, Mahvash A, Long J, Abdelsalam M, Avritscher R, Chasen B, Kaseb A, Kuban J, Odisio B, Murthy R, Teyatteti A, Macapinlac H, Kappadath SC. Survival outcomes for Y-90 transarterial radioembolization with and without sorafenib for unresectable hepatocellular carcinoma patients. J Hepatocell Carcinoma 7:117-131, doi:10.2147/JHC.S248314, 2020. e-Pub 2020.
Siman W, Mawlawi OR, Mourtada F, Kappadath SC. Systematic and random errors of PET-based 90 Y 3D dose quantification. Med Phys 47(6):2441-2449, 2020. e-Pub 2020. PMID: 32135025.
Buettner S, AJAT B, Margonis GA, Brown DB, Taylor KB, Borgmann AJ, Kappadath SC, Mahvash A, IJzermans JNM, Weiss MJ, Lamarca A, Bell JK, Valle JW, Hagendoorn J, Koerkamp BG, Sze DY, MGEH L. Yttrium-90 Radioembolization in Intrahepatic. J Vasc Interv Radiol 31(7):168-176, 2020. e-Pub 2020.
Salem R, Padia SA, Lam M, Bell J, Chiesa C, Fowers K, Hamilton B, Herman J, Kappadath SC, Leung T, Portelance L, Sze D, Garin E. Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group. Eur J Nucl Med Mol Imaging 46(8):1695-1704, 2019. e-Pub 2019. PMID: 31098749.
AJAT B, Kappadath SC, Ahmadzadehfar H, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, MGEH L. Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases: International Multicenter Study on Efficacy and Toxicity. Cardiovasc Intervent Radiol 42(3):413-425, 2019. e-Pub 2019. PMID: 30603975.
Siman W, Mikell JK, Mawlawi OR, Mourtada F, Kappadath SC. Dose volume histogram-based optimization of image reconstruction parameters for quantitative 90 Y-PET imaging. Med Phys 46(1):229-237, 2019. e-Pub 2019. PMID: 30375655.
Pan T, Einstein SA, Kappadath SC, Grogg KS, Lois Gomez C, Alessio AM, Hunter WC, El Fakhri G, Kinahan PE, Mawlawi OR. Performance evaluation of the 5-Ring GE Discovery MI PET/CT system using the national electrical manufacturers association NU 2-2012 Standard. Med Phys 46(7):3025-3033, 2019. e-Pub 2019. PMID: 31069816.
Henry EC, Mawko G, Tonkopi E, Frampton J, Kehoe S, Boyd D, Abraham R, Gregoire M, O’Connell K, Kappadath SC, Syme A. Quantification of the inherent radiopacity of glass microspheres for precision dosimetry in yttrium-90 radioembolization. Biomed. Phys. Eng. Express 5:055011, 2019. e-Pub 2019.
Popnoe DO, Ng CS, Zhou S, Kappadath SC, Pan T, Jones AK. Comparison of enhancement quantification from virtual unenhanced images to true unenhanced images in multiphase renal Dual‐Energy computed tomography: A phantom study. J Appl Clin Med Phys 20(8):171-179, 2019. e-Pub 2019.
Vu T, Schellingerhout D, Guha-Thakurta N, Sun J, Wei SW, Kappadath SC, Perrier N, Kim EE, Rohren E, Chuang HH, Wong FC. Solitary parathyroid adenoma localization in Technitium Tc99m Sestamibi SPECT CT and multiphase multidetector 4CDT. Am J Neuroradiol 40:142-49, 2019. e-Pub 2019.
Lopez B, Mahvash A, MGEH L, Kappadath SC. Calculation of lung mean dose and quantification of error for 90Y-microsphere radioembolization using 99mTc-MAA SPECT/CT and diagnostic chest CT. Med Phys 46(9):3929-3940, 2019. e-Pub 2019. PMID: 31063600.
Bastiaannet R, Kappadath SC, Kunnen B, Braat AJAT, Lam MGEH, de Jong HWAM. The physics of radioembolization. EJNMMI Phys 5(1):22, 2018. e-Pub 2018. PMID: 30386924.
Kappadath SC, Mikell J, Balagopal A, Baladandayuthapani V, Kaseb A, Mahvash A. Hepatocellular Carcinoma Tumor Dose Response After 90Y-radioembolization With Glass Microspheres Using 90Y-SPECT/CT-Based Voxel Dosimetry. Int J Radiat Oncol Biol Phys 102(2):451-461, 2018. e-Pub 2018. PMID: 30191875.
Pahlka RB, Kappadath SC, Mawlawi O. A Monte Carlo simulation of coincidence detection and imaging of gamma-ray cascades with a scintillation camera. Biomed Phys Eng Express 4, 055012, 2018. e-Pub 2018.
Balagopal A, Kappadath SC. Characterization of 90Y-SPECT/CT self-calibration approaches on the quantification of voxel-level absorbed doses following 90Y-microsphere selective internal radiation therapy. Med Phys 45(2):875-83, 2018. e-Pub 2018. PMID: 29172243.
AJAT B, Kappadath SC, Bruijnen RCG, van den Hoven AF, Mahvash A, HWAM DJ, MGEH L. Adequate SIRT activity dose is as important as adequate chemotherapy dose. Lancet Oncol 18(11):e636. doi: 10.1016/S1470-2045(17)30811-2, 2017. e-Pub 2017. PMID: 29208390.
Bache ST, Kappadath SC. Quantitation of tumor uptake with molecular breast imaging. Med Phys 44(9)(9):4593-4607, 2017. e-Pub 2017. PMID: 28600857.
Siman W, Mawlawi OR, Mikell JK, Mourtada F, Kappadath SC. Effects of image noise, respiratory motion, and motion compensation on 3D activity quantification in count-limited PET images. Phys Med Biol 62(2):448-464, 2017. e-Pub 2017. PMID: 28000618.
Siman W, Kappadath SC. Comparison of step-and-shoot and continuous-bed-motion positron emission tomography modes of acquisition for limited-view organ scans. J Nucl Med Technol 45(4):290-296, 2017. e-Pub 2017. PMID: 29042468.
Mikell JK, Mahvash A, Siman W, Baladandayuthapani V, Mourtada F, Kappadath SC. Selective internal radiation therapy with 90Y glass microspheres: biases and uncertainties in absorbed dose calculations between clinical dosimetry models. Int J Radiat Oncol Biol Phys 96(4):888-896, 2016. e-Pub 2016. PMID: 27623307.
Siman W, Mikell JK, Kappadath SC. Practical reconstruction protocol for quantitative 90Y bremsstrahlung SPECT/CT. Med Phys 43(9):5093-5103, 2016. e-Pub 2016. PMID: 27587040.
Mikell J, Kappadath SC, Wareing T, Erwin WD, Titt U, Mourtada F. Evaluation of a deterministic grid-based boltzmann solver (GBBS) for voxel-level absorbed dose calculations in nuclear medicine. Phys Med Biol 61(12):4564-4582, 2016. e-Pub 2016. PMID: 27224727.
Mikell JK, Mahvash A, Siman W, Mourtada F, Kappadath SC. Comparing voxel-based absorbed dosimetry methods in tumors, liver, lung, and at the liver-lung interface for 90Y microsphere selective internal radiation therapy. EJNMMI Phys 2(16):16, 2015. e-Pub 2015. PMID: 26501817.
Meier J, Kappadath SC. Characterization of the energy response and backscatter contribution for two electronic personal dosimeter models. J Appl Clin Med Phys 16(6):423-434, 2015. e-Pub 2015. PMID: 26699565.
Wait JM, Cody D, Jones AK, Rong J, Baladandayuthapani V, Kappadath SC. Performance evaluation of material decomposition with rapid kVp-switching dual energy CT and implications for assessing bone mineral density. AJR Am J Roentgenol 204(6):1234-1241, 2015. e-Pub 2015. PMID: 26001233.
Willowson KP, Tapner M, Kappadath SC, Bailey DL. A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: The QUEST Phantom Study. Eur J Nucl Med Mol Imaging 42:1202-1222, 2015. e-Pub 2015. PMID: 25967868.
Siman W, Silosky M, Kappadath SC. A revised monitor source method for practical deadtime count loss compensation in clinical planar and SPECT studies. Phys Med Biol 60(3):1199-216, 2015. e-Pub 2015. PMID: 25591740.
Hulme KW, Kappadath SC. Implications of CT noise and artifacts for quantitative (99m)Tc SPECT/CT imaging. Med Phys 41(4):042502, 2014. e-Pub 2014. PMID: 24694155.
Silosky M, Johnson V, Beasley C, Kappadath SC. Characterization of the count rate performance of modern gamma cameras. Med Phys 40(3):032502, 2013. e-Pub 2013. PMID: 23464339.
Siman W, Kappadath SC. Performance characteristics of a new pixelated portable gamma camera. Med Phys 39(6):3435-3444, 2012. e-Pub 2012. PMID: 22755723.
Kappadath SC. Effects of voxel size and iterative reconstruction parameters on the spatial resolution of 99mTc SPECT/CT. J Appl Clin Med Phys 12(4):3459, 2011. e-Pub 2011. PMID: 22089002.
Mathieu KB, Kappadath SC, White RA, Atkinson EN, Cody DD. An empirical model of diagnostic x-ray attenuation under narrow-beam geometry. Med Phys 38(8):4546-4555, 2011. e-Pub 2011. PMID: 21928626.
Hulme KW, Rong J, Chasen B, Chuang HH, Cody DD, Wong FC, Kappadath SC. A CT acquisition technique to generate images at various dose levels for prospective dose reduction studies. Am J Roentgenol 196(2):W144-51, 2011. e-Pub 2011. PMID: 21257855.
Kappadath SC, Erwin WD, Wendt RE. A novel method to evaluate gamma camera rotational uniformity and sensitivity variation. Med Phys 36(6):1947-1955, 2009. e-Pub 2009. PMID: 19610283.
Kappadath SC, Shaw CC. Dual-energy digital mammography: noise reduction techniques. Phys Med Bio 53:5421-43, 2008. e-Pub 2008.
Mawlawi O, Kappadath SC, Pan T, Macapinlac H. Factors affecting quantification in PET/CT imaging. Current Medical Imaging Reviews 4, 2008. e-Pub 2008.
Kappadath SC, Erwin WD, Wendt RE. Observed intercamera variability in clinically relevant performance characteristics for Siemens Symbia gamma cameras. Journal of Applied Clinical Medical Physics 7(4), 2006. e-Pub 2006. PMID: 17533358.
Kappadath SC, Shaw CC. Dual-energy digital mammography for calcification imaging: scatter and nonuniformity corrections. Med Phys 32(11):3395-408, 2005. e-Pub 2005. PMID: 18765887.
Lai CJ, Shaw CC, Whitman GJ, Johnston DA, Yang WT, Selinko V, Arribas E, Dogan B, Kappadath SC. Visibility of simulated microcalcifications-a hardcopy-based comparison of three mammographic systems. Med Phys 32(1):182-94, 2005. e-Pub 2005. PMID: 15719969.
Kappadath SC, Shaw CC. Quantitative evaluation of dual-energy digital mammography for calcification imaging. Phys Med Biol 49:2563-76, 2004. e-Pub 2004. PMID: 15272674.
Kappadath SC, Shaw CC. Dual-energy digital mammography: calibration and inverse-mapping techniques to estimate calcification thickness and glandular-tissue ratio. Med Phys 30(6):1110-7, 2003. e-Pub 2003. PMID: 12852535.
Altice PP, Cherry ML, Band DL, Buckley J, Guzik TG, Pl H, Kappadath SC, Macri JR, Matteson JL, McConnell ML, Ryan JM, Slavis KR, Stacy JG. MARGIE Minute of Arc Resolution Hard XRay/Gamma Ray Imaging Telescope for an Ultra Long Duration Balloon Mission. Advances in Space Research 30:1321, 2002. e-Pub 2002.
Lemacks MR, Kappadath SC, Shaw CC, Liu X, Whitman GJ. A dual-energy subtraction technique for microcalcification imaging in digital mammography: a signal-to-noise analysis. Med Phys 29(8):1739-51, 2002. e-Pub 2002. PMID: 12201421.
Weidenspointer F Varndorff M, Oberlack U, Morris D, Pluschke S, Diehl R, Kappadath SC, McConnell M, Ryan J, Schonfelder V, Steinle H. The COMPTEL instrumental line background. Astronomy and Astrophysics 368:347-368, 2001. e-Pub 2001.
Weidenspointner G, Bennett K, van Dijk R, Kappadath SC, Lockwood J, Morris D, Ryan J, Schönfelder V, Varendorff M. The Local Neutron flux at Low Earth-Orbiting Altitudes. Astronomy and Astrophysics Supp. Series 120(c):631-634, 1996. e-Pub 1996. PMID: 11542899.
Stacy JG, Kippen R, Kappadath SC, McConnell M, Morris D, Miller R, Connors A, Hersh B, Macri J, Simpson G, Schönfelder V, Steinle H, van Dijk R, Williams O. The Response of the CGRO COMPTEL Determined from Monte Carlo Simulation Studies. Astronomy and Astrophysics Supp. Series 120(c):691-694, 1996. e-Pub 1996.
Kappadath SC, Ryan K, Bennett J, Bloemen H, Forrest D, Hermsen W, Kippen R, McConnell M, Schönfelder V, van Dijk R, Varendorff M, Weidenspointner G, Winkler C. The Preliminary Cosmic Diffuse Gamma-Ray Spectrum from 800 keV to 30 MeV Measured with COMPTEL. Astronomy and Astrophysics Supp. Series 120 (c):619-622, 1996. e-Pub 1996.

Invited Articles

Kappadath SC, Mar M. CT Dose Report: Value and Values. Uptake-The SNMTS Newsletter 18(1), 2012. e-Pub 2012.
Mar M, Kappadath SC. CT Parameters: a hybrid technical reflection. Uptake - The Society of Nuclear Medicine Technologists Section (SNMTS) 16(6), 2010. e-Pub 2010.
Sreekumar P, Stecker F, Kappadath SC. The extragalactic diffuse gamma-ray emission. Proceedings of the Fourth Compton Symposium 410:344-358, 1997. e-Pub 1997.

Manuals, Teaching Aids, Other Teaching Publications

. Online CME. American Brachytherapy Society, Yttrium-90 Microspheres Permanent Implant Brachytherapy for Liver Tumors, 2022.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Quantitative SPECT in Radionuclide and External Beam Treatment Planning, 2021.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Imaging and Dosimetry for 90Y Microsphere Therapies, 2020.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Image-Guided 90Y Radionuclide Treatment Planning, Delivery, and Verification for Hepatic Cancers. American Association for Physicists in Medicine, 2019.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Yttrium-90 Microsphere Therapy: Emerging Trends and Future Directions. American Association for Physicists in Medicine, 2017.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, SPECT/CT: Basics, Quality Assurance, and Clinical Applications. American Association for Physicists in Medicine, 2016.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Molecular Breast Imaging: History and Recent Developments. American Association for Physicists in Medicine, 2016.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Recent Advances in SPECT/CT and PET/CT for Oncology. American Association for Physicists in Medicine, 2015.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Principles of PET/CT: Quality Control and Calibration. American Association for Physicists in Medicine, 2014.
. On-line CME: AAPM, Characterization of the count rate performance of modern gamma cameras. American Association for Physicists in Medicine, 2014.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Yttriium-90 Microsphere Therapy Planning and Dosimetry. American Association for Physicists in Medicine, 2012.
Mar M, Kappadath SC. CT Dose Report: Value and Values, 2012.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, Yttriium-90 Microsphere Therapy Planning and Dosimetry. American Association for Physicists in Medicine, 2011.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, SPECT/CT: Basics, Quality Assurance, and Clinical Applications. American Association for Physicists in Medicine, 2010.
. Online CME. American Board of Radiology (ABR) Maintenance of Certification (MOC) Self-Assessment Module (SAM) in Medical Physics, SPECT/CT: Basics, Quality Assurance, and Clinical Applications, American Association for Physicists in Medicine, http://www.aapm.org/education/ce/SAMsOfferings.asp, 2009.
. Online CME. Society of Nuclear Medicine Technologist Section (SNMTS) Continuing Education, Radiation Safety: Does your Environment get the Green Light?, Society of Nuclear Medicine, http://interactive.snm.org/index.cfm?PageID=4660, 2008.
. Online presentation. Magnetic resonance image guided breast biopsy equipment in a 3 Tesla environment:safety and image artifact evaluation, an online electronic presentation located at the American Journal of Roentgenology web based resource on Women's Imaging, http//womensimagingonline.arrs.org/item.cfm?itemID=36 (last access 9/2011), 2007.
. Online tutorial. Developing IDL application in Siemens e.soft environment, an online tutorial located at the ITT Visual Information System, http://www.ittvis.com/groups/siemens.asp (last access 9/2011), 2007.

Abstracts

Lopez B, Kelley B, Kappadath SC. Lung Dose Verification with SPECT & PET following 90Y-Microsphere Radioembolization 65(Supplement 2):241290, 2024. e-Pub 2024.
Abraham R, Verma A, Dobrowski D, KappadathSC. Multimodal Imageable Eye90 microsphere Radioembolization for Hepatocellular Carcinoma: 6-Month Interim Safety and Efficacy and 3-Month Liver Volume Results from a First-in-Human Trial 35(Supplement 3):S67-68, 2024. e-Pub 2024.
Shahbaziah H, Dabbous H, Brandon D, Xing M, Schuster D, Kappadath||/b. Comparison of 3D Voxel-Based Yttrium90 Dosimetry Quantification of Using Y90 PET/CT versus Y90 SPECT/CT 35(Supplement 3):S140, 2024. e-Pub 2024.
Kappadath SC, Henry EC, Mahvash A. Radioembolization for HCC patients with personalized yttrium-90 dosimetry for curative intent (RAPY90D): an interim analysis 49(Suppl 1):S53, 2023. e-Pub 2023.
Henry EC, Mahvash A, Lopez BP, Kappadath SC. Quantitative Comparison of Absorbed Dose Estimates Derived from 90Y-PET/CT and 90Y-SPECT/CT Imaging following 90Y-Radioembolization 64(Supplement 1):680, 2023. e-Pub 2023.
Abraham R, Arepally A, Liu D, Kappadath SC, Gregoire M, Verma A, Dobrowski D, Holden A. Initial Clinical Experience with a Novel Glass Radiopaque Yttrium-90 Radioembolization Microsphere for Treating Malignant Liver Tumors(34):S121, 2023. e-Pub 2023.
Henry EC, Lopez BP, Kappadath SC. Accuracy of in vivo 90Y activity and dose quantification based on 90Y-PET/CT following 90Y-Radioembolization 64(Supplement 1):741, 2023. e-Pub 2023.
Kappadath SC, Lopez BP. Absolute 99m Tc tumor activity uptake quantification with molecular breast imaging 49(Suppl 1):S152, 2023. e-Pub 2023.
Lopez BP, Rauch G, Kappadath SC. Absolute Breast 99mTc-sestamibi Quantification with Molecular Breast Imaging in Patients Undergoing Neoadjuvant Chemotherapy 64(Supplement 1):166, 2023. e-Pub 2023.
Lopez BP, Courtney EC, Riggs A, Kappadath SC. 90Y SIR-Spheres Activity Measurement with the New SIROS D-Vial Delivery Kit 64(Supplement 1):680, 2023. e-Pub 2023.
Kappadath SC, Henry EC, Lopez BP, Abdelsalam M, Chasen B, Kaseb A, Kuban J, Metwalli Z, Odisio B, Mahvash A. Radioembolization for HCC Patients with Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D): an interim analysis 63(Supplement 2):2375, 2022. e-Pub 2022.
Kokabi N, Cheng B, Arndt L, Brandon D, Galt J, Elsayed M, Bercu Z, Sethi I, Cristescu M, Kappadath SC, Schuster D. Accuracy of scout dose Y-90 for prospective personalized selective internal radiation therapy planning 33(6):S12-S13, 2022. e-Pub 2022.
Lopez BP, Kappadath SC. Absolute 99mTc tumor activity uptake quantification with Molecular Breast Imaging. J Nucl Med 63:3256, 2022. e-Pub 2022.
Mahvash A, Odisio B, Abdelsalam M, Murthy R, Kaseb A, Kappadath SC. Radioembolization for HCC patients with personalized yttrium-90 dosimetry for curative intent (RAPY90D): interim results 33(6):S92, 2022. e-Pub 2022.
Lopez BP, Rauch GM, Adrada B, Kappadath SC. Functional tumor diameter measurement with Molecular Breast Imaging 63(Supplement 2):2407, 2022. e-Pub 2022.
Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon A, Bryan J, Maitz C, Abraham R, Kappadath SC, Syme A. Precision Dosimetry in Yttrium-90 Radioembolization Through CT Imaging of Radiopaque Microspheres in a Rabbit Liver Model. Med Phys 49 (6):4181, 2022. e-Pub 2022.
Lai SY, Torres-Saavedra PA, Dunlap NE, Beadle BM, Chang SS, Subramaniam RM, Yu JQ, Lowe VJ, Khan SA, Truong MT, Bell D, Liu CZ, Kovalchuk N, Rong Y, Abazeed ME, Kappadath SC, Harris J, Le Q. NRG Oncology HN006: Randomized phase II/III trial of sentinel lymph node biopsy versus elective neck dissection for early-stage oral cavity cancer. J Clin Oncol, 2021. e-Pub 2021.
Kappadath SC. Quantitative SPECT in Radionuclide and External Beam Treatment Planning. Med Phys 48(6):e183, 2021. e-Pub 2021.
Kappadath SC, Lopez BP, Mahvash A. Organ doses following intra-hepatic-arterial administration of 99mTc-MAA in planning dosimetry for 90Y-SIRT. Med Phys 48(6):e141, 2021. e-Pub 2021.
Kokabi M, Cheng B, Brandon D, Bercu Z, Sethi I, Mircea C, Galt J, Whitmore M, Kappadath SC, Majdalany B, Schuster D. Accuracy of scout dose Y90 liver biodistribution for personalized treatment planning of Y90 radioembolization of hepatocellular carcinoma: interim analysis of a prospective clinical trial. JVIR 32, SIR Annual Meeting Suppl. 4, 2021. e-Pub 2021.
Lopez BP, Rauch GM, Kappadath SC. Automatic tumor functional diameters with Molecular Breast imaging for treatment response assessments. Med Phys 48(6):e168, 2021. e-Pub 2021.
Mahvash A, Chartier S, Turco M, Habib P, Griffith S, Brown S, Kappadath SC. A prospective, multicenter, open-label, clinical trial design to evaluate the safety and efficacy of 90y resin microspheres for treatment of unresectable hepatocellular carcinoma (hcc): Doorway90. AHPBA On-Demand, 2021. e-Pub 2021.
Kappadath SC, Teyateeti A, Long J, Abdelsalam M, Avritscher R, Chasen B, Kuban J, Odisio B, Murthy R, Macapinlac H. Survival outcomes for transarterial 90Y-radioembolization with glass microspheres in advanced hepatocellular carcinoma patients 31(3)(S244-245), 2020. e-Pub 2020.
Thomas MA, Mahvash A, Abdelsalam M, Kaseb A, Kappadath SC. Planning dosimetry for 90Y-therapy: Evaluating the predictive power of 99mTc-MAA and the partition model. Med Phys 47(6):2623, 2020. e-Pub 2020.
Kappadath SC, Lopez BP, Mahvash A, Toskich B. Adjustments to prescribed mean radiation dose based on actual tumor dose margins for segmental ablative 90-Y radioembolization 31(3)(S239), 2020. e-Pub 2020.
Kappadath SC, Lopez BP, MGEH L, Mahvash A. Improving accuracy of predicted lung dosimetry in 90Y-microsphere radioembolization with 99mTc-MAA planar scintigraphy 31(3)(S242), 2020. e-Pub 2020.
Kappadath SC, Lopez B, Di Tusa R, Braat A, Mahvash A, Toskich B. Parametric model adjustment of prescribed mean radiation dose to ensure complete coverage at tumor margins during ablative 90Y-radioembolization. Med Phys 47(6):2630, 2020. e-Pub 2020.
Lopez B, Mahvash A, Long J, Lam M, Kappadath SC. Improving the accuracy of predicted lung dosimetry in 90Y-microsphere radioembolization with 99mTc-MAA planar scintigraphy. Med Phys 47(6):2651, 2020. e-Pub 2020.
Thomas MA, Lopez, B, Neff A, Mahvash A, Kappadath SC. Predicting new Y90 administered activity in 90Y-radioembolization from post-therapy 90Y-SPECT/CT images. Med Phys 47(6):2623, 2020. e-Pub 2020.
Lopez B, Guan F, Rauch G, Kappadath SC. Tumor specific 99mTc-sestamibi quantification in molecular breast imaging with Monte Carlo simulations. Med Phys 47(6):2645, 2020. e-Pub 2020.
Mahvash A, Chasen B, Briones Dimayuga M, Santiago G, Patel M, Odisio B, Le D, Kuban J, Abdelsalam M, Avritscher R, Murthy R, Kappadath SC. Feasibility of single-session in-room Yttrium-90 radioembolizatioRE) diagnostic angiography and treatment 30(3):S145–S146, 2019. e-Pub 2019.
Kokabi N, Sethi I, Mir D, Schuster DM, Lee JS, Kappadath SC, Risk B, Galt JR. Evaluation of Utility of Low Dose Yttrium-90 for Radioembolization Treatment Planning Using SPECT/CT and PET/CT - A phantom study. Eur J Nucl Med Mol Imaging 46 (Suppl 1):5259, 2019. e-Pub 2019.
Kappadath SC. Survival outcomes for transarterial Y-90 radioembolization with glass microspheres in hepatocellular carcinoma patients: a single-institution experience. Eur J Nucl Med Mol Imaging 46 (Suppl 1):5257, 2019. e-Pub 2019.
Henry C, Tonkopi E, O’Connell K, Westcott M, Lewandowski R, Liu D, Boyd D, Kehoe S, Gregoire M, Mawko G, Kappadath SC, Syme A, Abraham R. Novel radiopaque Yttrium-90 glass microspheres in a porcine model: clinical potential for real-time targeting and dosimetry 30(3):S230, 2019. e-Pub 2019.
Teyatteti A, Mahvash A, Long J, Abdelsalam M, Avritscher R, Chasen B, Kaseb A, Kuban J, Odisio B, Murthy R, Macapinlac H, Kappadath SC. Survival outcomes for transarterial Y-90 radioembolization with glass microspheres in hepatocellular carcinoma patients: a single-institution experience. J Nucl Med 60(430), 2019. e-Pub 2019.
Kappadath SC, Lopez B, Mahvash A. A Novel Lung Dose Calculation Methodology for Y90-Radioembolization using diagnostic chest-CT and Tc99m-MAA SPECT/CT 30(3):S144–S145, 2019. e-Pub 2019.
Lopez B, Balagopal A, Mahvash A, Kappadath SC. Evaluation of errors in common lung mass estimation methods used for mean lung dose calculation in 90Y-microsphere therapy planning. Nucl Med 59:1706, 2018. e-Pub 2018.
Kappadath SC, Lopez B, Mahvash A. A novel lung dose calculation methodology with precision analysis for Y90-radioembolization using diagnostic chest-CT and Tc99m-MAA SPECT/CT 45(Suppl 2):S196, 2018. e-Pub 2018.
Lopez B, Mahvash A, Kappadath SC. A Novel SPECT/CT-Based Lung Dose Estimation for Treatment Planning in Y90 Microsphere Radioembolization Therapy. Med Phys 45(6)(e390), 2018. e-Pub 2018.
Lopez B, Kappadath SC. Improving the sensitivity of Molecular Breast Imaging using a novel detector response function. J Nucl Med 59:581, 2018. e-Pub 2018.
Braat A, Stothers C, Mahvash A, Flamen P, Deroose C, Frilling A, Sze D, Kappadath SC, Brown D, Ahmadzadehfar H, and Lam M. International Multicenter Retrospective Study on the Safety of Radioembolization with Yttrium-90 Resin Microspheres in Neuroendocrine Carcinomas. J Nucl Med 58:1038, 2017. e-Pub 2017.
Lopez B, Rauch M, Adrada B, Bache S, Hess K, Kappadath SC. Quantifying Tc-99m sestamibi uptake in breast tumors using Molecular Breast Imaging. Med Phys 44(6):3263, 2017. e-Pub 2017.
Krishnan S, Braat A, Mahvash A, Lam M, and Kappadath SC. Dosimetry model-dependent biases in absorbed dose calculations following 90Y-microsphere therapy. J Nucl Med 2017 58:428, 2017. e-Pub 2017.
Siman W, Mawlawi OR, Mourtada F, Kappadath SC. Quantitative 90Y PET imaging: reconstruction optimization, systematic biases, and random errors. J Nucl Med 58:747, 2017. e-Pub 2017.
Kappadath SC, Balagopal A, Mahvash A. Uncertainties in geometric-mean based lung shunt fraction for 90Y radioembolization 44(Suppl 2):5800, 2017. e-Pub 2017.
Braat A, Mahvash A, Stothers C, Deroose C, Frilling A, Flamen P, Brown D, Sze D, Kappadath SC, Ahmadzadehfar H, and Lam M. International Multicenter Retrospective Study on the Safety of Radioembolization with Yttrium-90 Resin Microspheres After Systemic Radionuclide Therapy in Neuroendocrine Tumors. J Nucl Med 2017 58:529, 2017. e-Pub 2017.
Gates V, Vanderhoek M, Kappadath SC. Yttrium-90 Microsphere Therapy: Emerging Trends and Future Directions. Med Phys 44(6):3199-3189, 2017. e-Pub 2017.
Kairemo K, Kangasm A, Kappadath SC, Macapinlac H, and Joensuu T. A retrospective analysis of sodium fluoride (NaF-18)-PET/CT and Ga-68-PSMA PET/CT in the assessment of skeletal metastases prostate cancer using a volumetric 3-D analysis. J Nucl Med 58:756, 2017. e-Pub 2017.
Balagopal A, Kappadath SC. Effect of 90Y SPECT/CT self-calibration approaches on absorbed dose quantification following 90Y-microsphere selective internal radiation therapy (90Y-SIRT). Med Phys 44(6):3251-3252, 2017. e-Pub 2017.
Balagopal A, Mahvash A, Kappadath SC. Effect of differences in CT- and SPECT-based tumor delineation on tumor dose and dose response following 90Y Selective Internal Radiation Therapy (SIRT) 44(Suppl 2):5281, 2017. e-Pub 2017.
Kappadath SC, Lopez B, Adrada B, Hess K, Rauch G. Prediction of breast tumor response to neoadjuvant chemotherapy through quantitative 99mTc sestamibi Molecular Breast Imaging (MBI) 44(Suppl 2):5660, 2017. e-Pub 2017.
Bache S, Lopez B, Rauch G, Adrada B, Jessop A, Kappadath SC. Quantification of tumor uptake with molecular breast imaging (MBI) 42(Suppl 1):S149, 2016. e-Pub 2016.
Bache S, Adrada B, Jessop, A, Rauch G, Kappadath SC. Quantification of tumor uptake with molecular breast imaging (MBI). J Nucl Med 57(2):535, 2016. e-Pub 2016.
Kappadath SC, Matthies P, Grosser O, Tam A, Kappadath S, Navab N. Interventional nuclear imaging for SIRT – a phantom study. J Nucl Med 57(2):304, 2016. e-Pub 2016.
Pahlka R, Kappadath SC, Mawlawi O. Metabolomics of In-111 using coincidence imaging. J Nucl Med 57(2):1874, 2016. e-Pub 2016.
Erwin W, Khouri I, Gress D, Kappadath SC, Jessop A. Target organ dose range-based, high-activity Zevalin®-inclusive non-myeloablative conditioning for allogeneic stem cell transplantation: a stratified approach. J Nucl Med 57(2):1453, 2016. e-Pub 2016.
Kairemo K, Joensuu T, Kappadath SC, Macapinlac H. A retrospective comparative study of sodium fluoride (NaF-18)-PET/CT and fluorocholine (F-18-CH) PET/CT in the evaluation skeletal metastatic prostate cancer using a volumetric 3-D analysis. J Nucl Med 57(2):1553, 2016. e-Pub 2016.
Kairemo K, Jessop A, Kappadath SC, Macapinlac H. A prospective comparative study of using ultrasonography (US), 4D-CT and parathyroid dual-phase scintigraphy with SPECT in patients with primary hyperparathyroidism. J Nucl Med 57(2):263, 2016. e-Pub 2016.
Siman W, Mawlawi O, Mourtada F, Kappadath SC. Effects of image noise and reconstruction parameters on tumor dosimetry using 90Y PET/CT. J Nucl Med 57(2):1957, 2016. e-Pub 2016.
Kappadath SC, Mikell J, Baladandayuthapani V, Mourtada F, Mahvash A. HCC tumor dose response characterization following 90Y-microsphere therapy. J Nucl Med 57(2):298, 2016. e-Pub 2016.
Mahvash A, Mikell J, Siman W, Odisio B, Murthy R, Kappadath SC. Quantifying differences in tumor uptake between planning 99mTc-MAA and post-therapy microsphere SPECT/CT using the balloon occlusion technique for common hepatic artery administration. J Vasc Interv Radiol 27(3S):111-112, 2016. e-Pub 2016.
Pahlka R, Kappadath SC, Mawlawi O. Performance of In-111 coincident gamma-ray counting: a monte carlo simulation. Med Phys 43:3680, 2016. e-Pub 2016.
Siman W, Mawlawi O, Mikell J, Mourtada F, Kappadath SC. Effect of image noise, respiratory motion, and motion compensation on quantitative accuracy of 90Y PET/CT based 3D absorbed doses following 90Y-microsphere therapy 42(Suppl 1):S227, 2016. e-Pub 2016.
Khouri I, Erwin B, Gulbis A, Turturro F, Kappadath SC, Gress D, Valverde R, Jabbour E, Bassett R, Jessop A. Stratified intense-dose-Yttrium-90 Ibritumumab (90YIT) with bendamustine + fludarabine nonmyeloablative conditioning for allogenic stem cell transplantation in b-cell malignancies. Blood 128(22):662, 2016. e-Pub 2016.
Kappadath SC, Mikell J, Siman W, Baladandayuthapani V, Mourtada F, Mahvash A. Interpreting reported absorbed doses for 90Y microsphere therapy: 120 Gy is not equal to 120 Gy. J Vasc Interv Radiol 27(3S):111, 2016. e-Pub 2016.
Siman W, Mikell J, Kappadath SC. Practical reconstruction protocol for quantitative 90Y bremsstrahlung SPECT/CT. Med Phys 43:5093, 2016. e-Pub 2016.
Mikell J, Siman W, Mourtada F, Kappadath SC. Validation of a GATE Gamma Camera Model for the Siemens Symbia. Med Phys 42(6):3203, 2015. e-Pub 2015. PMID: 26127151.
Mikell J, Mourtada F, Wareing T, Kappadath SC. Clinical Implementation of a Grid-Based Boltzmann Solver with Adaptive Meshing for Nuclear Medicine Dosimetry. Med Phys 42(6):3709, 2015. e-Pub 2015. PMID: 26129451.
Siman W, Kappadath SC, Mawlawi O. Performance Characterization of Regularized-Reconstruction Algorithm for 90Y PET/CT Images. Med Phys 42(6):3658, 2015. e-Pub 2015. PMID: 26129176.
Kappadath SC, Mikell J, Baladandayuthapani V, Siman W, Mourtada F, Mahvash A. Hepatocellular carcinoma tumor dose heterogeneity and response using 3D voxel-based dosimetry following 90Y-microsphere therapy 26(2):S88, 2015. e-Pub 2015.
Mikell J, Mourtada F, Wareing T, Kappadath SC. Voxel-level dosimetry with a grid-based Boltzmann solver for patient-specific nuclear medicine dosimetry 42(Suppl 1):S49, 2015. e-Pub 2015.
Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Differences between four voxel-based dosimetry methods for 90Y microsphere therapy. J Nucl Med 56(3):1277, 2015. e-Pub 2015.
Mikell J, Mahvash A, Mourtada F, Kappadath SC. Implications of four different voxel-based dosimetry models for liver and lung following 90Y microsphere therapy 26(2):S190–S191, 2015. e-Pub 2015.
Siman W, Mikell J, Kappadath SC. Uncertainties in calibration for quantitative 90Y SPECT/CT. J Nucl Med 5(3):1748, 2015. e-Pub 2015.
Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Partition model absorbed dose biases and variability due to tumor-to-normal-liver ratios following 90Y microsphere therapy 42(Suppl 1):S135, 2015. e-Pub 2015.
Mikell J, Kappadath SC, Wareing T, Mourtada F. Validating a grid-based Boltzmann solver for nuclear medicine applications in homogeneous and heterogeneous materials for voxel-based absorbed doses. J Nucl Med 56(3):542, 2015. e-Pub 2015.
Kappadath SC, Mikell J, Baladandayuthapani V, Mourtada F, Mahvash A. HCC tumor-dose response using voxel-based dosimetry following 90Y-microsphere therapy. J Nucl Med 56(3):572, 2015. e-Pub 2015.
Siman W, Mawlawi O, Rohren E, Kappadath SC. Effect of respiratory motion on activity quantification in post-therapy 90Y-microphone PET/Ct image. J Nucl Med 56(3):485, 2015. e-Pub 2015.
Bache S, Adrada B, Jessop A, Rauch G, Kappadath SC. Scatter and attenuation correction approaches for quantitative molecular breast imaging. J Nucl Med 56(3):45, 2015. e-Pub 2015.
Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Biases and variability in partition model absorbed doses following Y90 microsphere therapy. J Nucl Med 56(3):1336, 2015. e-Pub 2015.
Mikell J, Kappadath SC, Wareing T, Mourtada F. Evaluation of a Grid-Based Boltzmann Solver for Nuclear Medicine Voxel-Based Dose Calculations. Med Phys 41(6):488, 2014. e-Pub 2014.
Mikell J, Siman W, Mahvash A, Mourtada F, Kappadath SC. Kernel Based Dosimetry for 90Y Microsphere Liver Therapy Using 90Y Bremsstrahlung SPECT/CT. Med Phys 41(6):438, 2014. e-Pub 2014.
Gress DA, Kappadath SC. A Robust and Improved Method of Analysis for Dose Calibrator Linearity Data Based On First Principles. Med Phys 41(6):131, 2014. e-Pub 2014.
Siman W, Kappadath SC. Dead Time Count Loss Compensation in SPECT/CT: Projection Versus Global Correction. Med Phys 41(6):134, 2014. e-Pub 2014.
Siman W, Kappadath SC. Alternative Analytic Solution to the Paralyzable Detector Model to Calculate Deadtime and Deadtime Loss. Med Phys 41(6):105, 2014. e-Pub 2014.
Siman W, Mawlawi OR, Kappadath SC. 90Y PET/CT quantitative accuracy and image quality. J Nucl Med 55(1):507P, 2014. e-Pub 2014.
Kappadath SC, Erwin WD, Santiago G, Mahvash A. Implications of immediate versus delayed imaging for estimation of lung shunt in 90Y microsphere therapy planning. J Nucl Med 55(1):494P, 2014. e-Pub 2014.
Kappadath SC, Mikell J, Mourtada F, Mahvash A. Voxel-based dosimetry and radiobiological modeling of HCC tumor response after 90Y microsphere therapy. J Nucl Med 55(1):151P, 2014. e-Pub 2014.
Siman W, Kappadath SC. SPECT deadtime count loss correction using monitor source method. J Nucl Med 55(1):178P, 2014. e-Pub 2014.
Passalaqua S, Kappadath SC, Branch D, Ross S, Stearns CW, Schomer D, Mawlawi OR. Qualitative and quantitative evaluation of regularized PET image reconstruction. J Nucl Med 55(1):174P, 2014. e-Pub 2014.
Siman W, Kappadath SC. Assessment of continuous-bed-motion (CBM) and step & shoot (SS) modes for 90Y PET/CT scan. J Nucl Med 55(1):81P, 2014. e-Pub 2014.
Mikell J, Kappadath SC. Voxel-based partial volume correction for accurate quantitative voxel values. J Nucl Med 55(1):518P, 2014. e-Pub 2014.
Mikell J, Mourtada F, Mahvash A, Kappadath SC. Characterization of tumor dose heterogeneity for 90Y microsphere therapies using voxel-based dosimetry. J Nucl Med 55(1):31P, 2014. e-Pub 2014.
Subbiah V, Rohren E, Huh W, Kappadath SC, Anderson P. Phase 1 dose escalation trial of intravenous radium 223 dichloride alpha-particle therapy in osteosarcoma 32:15(Suppl):TPS10600, 2014. e-Pub 2014.
Kappadath SC, Mikell J, Baladandayuthapani V, Mourtada F, Mahvasg A. Hepatocellular carcinoma tumor response using voxel-based dosimetry following 90Y-microsphere therapy 41(2):S240, 2014. e-Pub 2014.
Siman W, Mawlawi O, Kappadath SC. 90Y PET/CT quantitative accuracy and image quality. Int J Cancer Ther Oncol 2(2), 2014. e-Pub 2014.
Siman W, Kappadath SC. SPECT deadtime count loss correction using monitor source method. Int J Cancer Ther Oncol 2(2), 2014. e-Pub 2014.
Mikell J, Kappadath SC. Voxel-based partial volume correction for accurate quantitative voxel values. Int J Cancer Ther Oncol 2(2), 2014. e-Pub 2014.
Mikell J, Mourtada F, Mahvash A, Kappadath SC. Characterization of tumor dose heterogeneity for 90Y microsphere therapies using voxel-based dosimetry. Int J Cancer Ther Oncol 2(2), 2014. e-Pub 2014.
Wong F, Vu T, Wong S, Schellingerhout D, Chuang H, Guha-Thakurta N, Kim E, Kappadath SC, Perrier N. Localization of parathyroid adenomas by Tc99m sestamibi SPECT-CT, contrast-enhanced multi-phase CT (4D-CT) and combination of SPECT-CT and 4D-CT. Radiological Society of North America, 2013. e-Pub 2013.
Meier J, Kappadath SC. Energy Response Characterization and Calibration of Electronic Personal Dosimeters. Med Phys 40(6):39, 2013. e-Pub 2013.
Kappadath SC, Cooney S, Gonzalez J, Jones S, Mar M, and Chasen B. Inter-technologist variability in estimates of lung shunt fraction for 90Y-microsphere therapy planning 54(Supplement 2):323P, 2013. e-Pub 2013.
Siman W, Kappadath SC. Energy window based scatter correction for improved 90Y bremsstrahlung imaging (Highlighted in the Physics and Instrumentation Track of the SNMMI annual meeting) 54(Supplement 2):527P, 2013. e-Pub 2013.
Erwin WD, Mar M, Kappadath SC. Anterior-only versus geometric mean 90Y microspheres lung shunt estimation: Implications for in-room, single-view gamma camera imaging 54(Supplement 2):507P, 2013. e-Pub 2013.
Silosky M, Kappadath SC. Effects of source activity distribution, input count rate, and spectral conditions on reproducibility of deadtime estimates using the dual source method 54(Supplement 2):501P, 2013. e-Pub 2013.
Valiollahzadeh SM, Kappadath SC, Clark J, and Mawlawi O. PET image reconstruction from partially sampled data using Poisson compressive sensing 54(Supplement 2):518P, 2013. e-Pub 2013.
Siman W, Silosky M, Kappadath SC. Deadtime count-loss compensation method for quantitative SPECT/CT imaging 40(2):S158, 2013. e-Pub 2013.
Kappadath SC, Mikell J, Baladandayuthapani, Mourtada VF, Mahvash A. Hepatocellular carcinoma tumor response using voxel-based dosimetry following 90Y-microsphere therapy 40(2):S235, 2013. e-Pub 2013.
Kappadath SC. MO-A-217BCD-02: Yttrium-90 Microsphere Therapy Planning and Dose Calculations. Med Phys 39(6Part20):3858, 2012. e-Pub 2012. PMID: 28517496.
Silosky M, SC K. SU-D-217A-02: Effects of Enegy-Window Width and Spectral Effective Energy on Estimation of Gamma Camera Deadtime Using the Decay Method. Med Phys 39(6Part3):3620, 2012. e-Pub 2012. PMID: 28517402.
Maclellan C, Hobbs BP, Chasen B, Murthy R, Mahvash A, SC K. Absorbed dose differences in 90Y microsphere therapy between pre-treatment 99m Tc-MAA and post-treatment 90Y scans. J Nucl Med 53(1):323p, 2012. e-Pub 2012.
Gonzalez JA, McCoy AP, Mar MV, Kappadath SC. Identifying optimal SPECT acquisition for liver imaging using 99m Tc-MAA. J Nucl Med 53(1):591p, 2012. e-Pub 2012.
Erwin WD, Mar MV, Kappadath SC. Post-90Y microsphere liver-directed brachytherapy bremsstrahlung versus treatment planning 99m Tc-MAA scanning lung shunt. J Nucl Med 53(1):80p, 2012. e-Pub 2012.
Silosky M, Kappadath SC. Effects of energy-window width and spectral effective energy on estimation of gamma camera deadtime using the decay method. Med Phys 39(6):3620, 2012. e-Pub 2012.
Siman W, Kappadath SC. Performance characteristics of a new pixilated portable gamma camera (Highlighted in the Physics and Instrumentation Track of the SNMMI annual meeting). J Nucl Med 52(6(1)):96P, 2011. e-Pub 2011. PMID: 22755723.
Mawlawi OR, Erwin WD, Chang T, Kappadath SC. Effects of scan time and injected dose on myocardial perfusion SPECT imaging. J Nucl Med 52(6(1)):462P, 2011. e-Pub 2011.
Silosky M, Kappadath SC. Investigation of spectral effects on measurement of gamma camera maximum count rate. J Nucl Med 52(6(1)):439P, 2011. e-Pub 2011.
Winslow J, Kappadath SC. Image quality and patient dose dependence on CT scan parameters for ATCM (CareDose4D). Med Phys(38):3398, 2011. e-Pub 2011.
Kappadath SC, Wendy S. Performance evaluation of a new commercially available portable pixelated gamma camera for 99mTc-scintimammography. Med Phys(38):3431, 2011. e-Pub 2011.
Siman W, Kappadath SC, Rong J. Weekly exposure contributions from radioactive patients in a busy comprehensive imaging center. Med Phys(38):3410, 2011. e-Pub 2011.
Rong J, Kappadath SC, Schellingerhout D. Measurement of skin dose from CT brain perfusion scans. Med Phys(38):3844, 2011. e-Pub 2011.
Kappadath SC, Mawlawi OR. Evaluation of Y90 PET/CT for imaging and quantifying Y90 dose in vivo. J Nucl Med 52(6(1)):453P, 2011. e-Pub 2011.
Wong F, Vu T, Chuang H, Schellingerhout D, Kappadath SC, Johnson V, Rohren E, Perrier N, Kim EE. Comparison of ultrasonography, Tc-99m sestamibi SPECT-CT and contrast-CT in the localization of parathyroid adenomas. J Nucl Med 52(6(1)):166P, 2011. e-Pub 2011.
Onumah N, Kappadath SC. Effect of varying the scatter window size on the accuracy of TEW scatter correction for Sm-153. J Nucl Med 51(6(2)):261P, 2010. e-Pub 2010.
Hulme KW, Kappadath SC. Implications of low-dose CT on quantitative 99mTc and 111In SPECT imaging 51(6):(Supplement2) 68P, 2010. e-Pub 2010.
Greer T, Xydas N, Kappadath SC. Effects of 99mTc administration on fan-beam DEXA bone mineral density measurements. J Nucl Med 51(6(2)):390P, 2010. e-Pub 2010.
Kappadath SC. A scatter correction algorithm for quantitative yttrium-90 SPECT imaging. Med Phys 37(6):3139, 2010. e-Pub 2010.
Kappadath SC. Assessment of attenuation correction with intravenous contrast CT images on quantitative 99mTc-sestamibi SPECT/CT uptake in thyroid and parathyroid. J Nucl Med 51(2):260P, 2010. e-Pub 2010.
Kappadath SC. Effects of intravenous CT contrast on attenuation correction of non-bone 99mTc SPECT/CT (Highlighted in the Physics and Instrumentation Track of the SNMMI annual meeting). J Nucl Med 51(6(2)):67P, 2010. e-Pub 2010.
Winslow J, Kappadath SC. Effect of CT scan parameters on adult and pediatric CT dose when using automatic tube current modulation. Med Phys 37(6):3102, 2010. e-Pub 2010.
Hulme KW, Kappadath SC. Propagation of dose- and radial-dependent CT noise into reconstructed SPECT images. J Nucl Med 50(2):106P, 2009. e-Pub 2009.
Boitnott K, Kappadath SC, White A, Atkinson A, Cody D. A new method for calculating the half-value layer of x-ray beams. Med Phys 36(6):2471, 2009. e-Pub 2009.
Kappadath SC, Erwin WD. Effects of pixel size and OSEM iteration parameters on Tc-99m SPECT resolution. Med Phys 36(6):2427, 2009. e-Pub 2009.
Kappadath SC, Erwin WD, Mutha P, Prasad S, Murthy R. Comparison of three radiation dosimetry models for Yttrium-90 microspheres radioembolotherapy. J Nucl Med 50(2):P54, 2009. e-Pub 2009.
Hulme KW, Kappadath SC. Quantitative image quality assessment of high-dose CT images simulated by averaging multiple low-dose CT images for prospective CT dose reduction strategies. Med Phys 36(6):2436, 2009. e-Pub 2009.
Kappadath SC, Erwin WE. Comparison of three sensitivity calibration methods to quantify SPECT/CT-based tumor uptake of Sm-153 EDTMP 49(5):Supplement 1, 398P-399P, 2008. e-Pub 2008.
Kappadath SC, Erwin WE, Wendt RE. A novel method to evaluate gamma camera rotational uniformity and sensitivity variation 48 (5):Supplement 2, 162P, 2007. e-Pub 2007.
Jones AK, Kappadath SC. Comparison of digital tomosynthesis technology with conventional technology for intravenous pyelogram. Med Phys 34(6):2364, 2007. e-Pub 2007.
Yang WT, Shaw CC, Chen L, Altunbas MC, Wang T, Lai C, Kappadath SC, Tu S, Liu X, Sahin A, Hunter K, Whitman GJ. Cone beam breast CT a feasibility study with surgical mastectomy specimens. Am J Roentgenol 5:188, 2007. e-Pub 2007.
Kappadath SC, Stafford RJ, Elliott AM, Whitman GJ. Magnetic resonance image-guided breast biopsy equipment in a 3 Tesla environment: safety and image artifact evaluation. Am J Roentgenol 5:188, 2007. e-Pub 2007.
Kappadath SC, Wendt RE. Assessment of the radiation shielding for a busy PET/CT facility. Med Phys 34 (6):2597, 2007. e-Pub 2007.
Erwin WE, Wendt RE, Kappadath SC, Gayed IW. Principal component analysis (PCA) based radionuclide separation in simultaneous dual-isotope 201 TI/123 I cardiac imaging 48:(Supplement 2) 419P-420P, 2007. e-Pub 2007.
Kappadath SC, Erwin WE, Wendt RE. Observed inter-camera variability of clinically relevant performance characteristics for Siemens Symbia gamma cameras. Med Phys 33(6):2014, 2006. e-Pub 2006.
Erwin WE, Kappadath SC, Devaraju V, Wendt RE. Performance characteristics of a new SPECT-CT scanner for imaging Tc-99m and In-111 5:47 Supplement 1,405P, 2006. e-Pub 2006.
Yang WT, Shaw CC, Chen L, Cem A, Wang T, Lai CJ, Kappadath SC, Tu SJ, Liu X, Whitman GJ. Cone beam breast CT a feasibility study with surgical mastectomy specimens. The San Antonio Breast Cancer Symposium, San Antonio, TX, 2005. e-Pub 2005.
Shaw CC, Chen L, Altunbas M, Wang T, Lai CJ, Tu SJ, Liu X, Kappadath SC. Imaging properties of cone beam breast CT - effects of detector properties and imaging conditions. Med Phys 32(6):2064, 2005. e-Pub 2005.
Lai CJ, Shaw CC, Sabloff B, Wang T, Liu X, Chen L, Meng Y, Tu SJ, Altunbas M, Kappadath SC. Effects of exposure and structural background on the detection of computer-simulated nodules in digital chest phantom images: 2-AFC study. Med Phys 32(6):2079, 2005. e-Pub 2005.
Kappadath SC, Shaw CC, Liu X, C-J L, Whitman G. Dual energy digital mammography for calcification imaging: a phantom study. RSNA 90th Annual Meeting, 2004. e-Pub 2004.
Kappadath SC, Shaw CC, Liu X, C-J L, Whitman G. Dual energy digital mammography for calcification imaging: a phantom study. Med Phys 31:1797, 2004. e-Pub 2004.
C-J L, Shaw, CC, Geiser W, Liu X, Kappadath SC, Altunbas M, Tu S, Wang T, Whitman G, Dempsey P. A contrast-detail phantom study to compare a slot-scanning digital mammography system with an a-Si/CsI flat-panel based system. Med Phys 31(6):1796, 2004. e-Pub 2004.
Kappadath SC, Shaw CC, C-J L, Lin X, Whitman G. Implementation of a dual-energy digital mammography technique for microcalcification imaging: a work-in-progress. Radiographics, 2003. e-Pub 2003.
Kappadath SC, Shaw CC, Liu X, C-J L, Balter P, Whitman G. Dual energy digital mammography for calcification imaging implementation under narrow beam geometry. Med Phys 30(6):1455, 2003. e-Pub 2003.
Balter P, Shaw CC, Kappadath SC, Liu X, C-J L. Scanning Equalization Digital Radiography (SEDR) A study of noise and scatter properties based on spot collimated images and noise simulation. Med Phys 30(6):1390, 2003. e-Pub 2003.
Kappadath SC, Shaw CC, C-J L, Lin X, Whitman G. Implementation of a dual-energy digital mammography technique for microcalcification imaging: a work-in-progress. Radiology 229:210-211, 2003. e-Pub 2003.
Shaw CC, Kappadath SC, Lai CJ, Liu X, Whitman GJ. Dual energy digital mammography signal to noise analysis and inverse mapping techniques. Era of Hope Department of Defense Breast Cancer Research Program Meeting, Orlando, Florida, 2002. e-Pub 2002.
Kappadath SC, Shaw CC. Dual-energy digital mammography calibration and inverse-wrapping techniques to estimate breast thickness, tissue composition, and/or calcification thickness. Med Phys 29(6):1306, 2002. e-Pub 2002.
Balter P, Kappadath SC, Liu X, Shaw CC. Noise simulation for studying the effects of scanning geometries and equalization schemes in scan exposure equalization digital radiography. Med Phys 29(6):1343, 2002. e-Pub 2002.
Kappadath SC, Shaw CC, C-J L, Liu X, Whitman GJ. Dual-energy digital mammography: Implementation on a flat-panel digital mammography system a work-in-progress. Supplement to Radiology 225:18, 2002. e-Pub 2002.

Book Chapters

Mosconi C, Kappadath SC, Odisio BC. Radioembolization for liver tumors. In: In: Blumgart’s Surgery of the Liver, Biliary Tract and Pancreas. Elsevier, 1303-1310, 2023.
Kappadath SC. Postradioembolization imaging using bremsstrahlung 90Y SPECT/CT. In: Handbook of Radioembolization Physics, Biology, Nuclear Medicine and Imaging. CRC Press, 221-227, 2016.
Pasciak AS, Kappadath SC. Image-based three-dimensional dosimetry following radioembolization. In: Handbook of Radioembolization Physics, Biology, Nuclear Medicine and Imaging. CRC Press, 251-261, 2016.
Kappadath SC, Rong J. Radiation shielding for CT scanners. In: Advances in Medical Physics. 3. Medical Physics Publishing, 257-269, 2010.

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Selected Presentations & Talks

Local Presentations

2024. Emerging Technologies and Technical Advances for Liver. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2022. 90Y-Radioembolization: Current status on dosimetry and clinical evidence. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2021. Updates on 90Y-Radioembolization Dosimetry and Dose-Response, Theranostics: Current Status and Emerging Opportunities at MD Anderson. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2019. Image-guided Radionuclide Therapy Dosimetry, Symposium on Cancer Theranostics and Molecular Imaging. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2016. Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry. Invited. UT Medical School. Houston, TX, US.
2015. Liver Directed Interventional Therapies and Dosimetric Considerations. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2015. Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2015. Molecular Breast Imaging. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2014. Recent Advances in PET/CT. Conference. Memorial Hermann Northwest Hospital. Houston, TX, US.
2014. Improving Response Modeling for Hepatocellular Carcinoma Treated with Radioactive 90Y Microspheres through Quantitative 90Y Bremsstrahlung SPECT/CT and Voxel-based Dosimetry. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2014. Deadtime Count-Loss Compensation for Quantitative SPECT/CT Imaging. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2014. Recent Developments in Quantitative Nuclear Medicine Imaging and Dosimetry. Invited. Rice University. Houston, TX, US.
2012. Computed Tomography: Image Quality and Dosimetry. Conference. Memorial Hermann Northwest Hospital. Houston, TX, US.
2011. Yttrium-90 Microsphere Therapy Planning and Dose Calculations. Conference. Memorial Hermann Northwest Hospital. Houston, TX, US.
2010. NM ACR Accreditation. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2010. SPECT/CT: Fundamentals and Clinical Applications. Conference. Memorial Herman Northwest Hospital. Houston, TX, US.
2009. TherasphereY90-microsphere Therapy Planning and Dose Calculations. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2007. An analysis of high-energy gamma-ray images acquired on a conventional gamma camera with coded apertures. Conference. 24th Annual Meeting of the Houston Society for Engineering in Medicine and Biology. Houston, TX, US.
2006. Developing IDL applications in Siemens e.soft environment. Conference. IDL Medical User Group. Houston, TX, US.
2004. Digital X-Ray Imaging Research. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.

Regional Presentations

2022. Quantitative SPECT for Radiopharmaceutical and External Beam Treatment Planning. Conference. Health Physics Society State of Texas Chapter. Online Conference, US.

National Presentations

2024. Summary of Recent Clinical Evidence and Treatment Scenarios with 90Y-Radioembolization. Invited. 66th Annual Association of Physicists in Medicine. Los Angeles, CA, US.
2024. Advanced Concepts in Lung and Liver Dosimetry for 90Y-Radioembolization. Invited. 66th Annual Association of Physicists in Medicine. Los Angeles, CA, US.
2024. Dosimetry Principles of Glass and Resin Microspheres. Invited. Y-90 Master Class. Chicago, IL, US.
2024. Review of NRC Safety Events in Radioembolization. Invited. Y-90 Master Class. Chicago, IL, US.
2024. Medical Physics Research Mentorship and Expanding Global Opportunities: From Insights to Impact. Invited. American Association for Physicists in Medicine, US.
2024. Must-Know Studies for MDT Tumor Board - DOSISPHERE. Invited. Society of Interventional Oncology. Long Beach, CA, US.
2024. Eye90 microspheres for the treatment of unresectable HCC. Invited. Society of Interventional Oncology. Long Beach, CA, US.
2023. 90Y-Microsphere Therapy: Dosimetry and Clinical Outcomes. Invited. Arizona Chapter of the American Association for Physicists in Medicine. Phoenix, AZ, US.
2023. Dosimetric Considerations in Heavily Treated Patients and Other Challenging Scenarios, Society of Interventional Oncology Symposium: Y90-radioembolization and Immunotherapy. Invited. Online Conference, US.
2023. NM Therapy and Dosimetry for Liver Tumors. Invited. IAEA Course on Targeted Radionuclide Therapies. Houston, TX, US.
2023. Dosimetry Principles with Resin 90Y-Microspheres. Invited. Y-90 Master Class. Chicago, IL, US.
2023. Dosimetry with SIR-Spheres Y-90 resin microspheres. Invited. Sirtex Medical. Webinar, US.
2023. How to Get Reimbursed for Pre- and Post-Treatment Dosimetry. Invited. Y-90 Master Class. Chicago, IL, US.
2023. Dosimetry Principles with Glass 90Y-Microspheres. Invited. Y-90 Master Class. Chicago, IL, US.
2023. Radioembolization for HCC patients with personalized Yttrium-90 dosimetry for curative intent (RAPY90D). Conference. GEST Annual Meeting. New York City, NY, US.
2023. Winfield Evan Lectureship: Advanced Dosimetry for 90Y-Microsphere Therapies. Invited. Southwest Chapter of the Society of Nuclear Medicine and Molecular Imaging (SWC-SNMMI). Sugarland, TX, US.
2023. A prospective, multicenter, open-label,clinical trial design to evaluate the safety and efficacy of Y90 resin microspheres for treatment of unresectable hepatocellular carcinoma (HCC): Duration Of Objective Response with arterial Yttrium-90 (DOORwaY90). Conference. TAG HCC Annual Meeting. Huntington, CA, US.
2023. Y90 Radioembolization for Primary & Metastatic Liver Cancer: One Size Does Not Fit All. Invited. Society of Interventional Oncology. Washington, DC, US.
2023. Resin Y-90 Dosimetry: From Theory to Practice. Invited. Society of Interventional Oncology. Washington, DC, US.
2022. Physics Theory, Y90 The Complete Course. Invited. Society of Interventional Radiology. San Diego, CA, US.
2022. Imaging for Radiation Therapy: Challenges and Solutions. Invited. AAPM Joint Imaging-Therapy Educational SAM Course. Washington, TX, US.
2022. 90Y-radioembolization dosimetry treatment planning. Invited. Nuclear Medicine Physicists Association of India. Online Conference, US.
2022. 99mTc-MAA Shunt Study: Determining Tumor to Normal Liver Perfusion Ratio, Y-90 Master Class. Invited. Society of Interventional Oncology. San Francisco, CA, US.
2022. 90Y-resin dosimetry: Optimization of Tumor and Liver Parenchyma Dose, Y-90 Master Class. Invited. Society of Interventional Oncology. San Francisco, CA, US.
2021. Quantitative Molecular Breast Imaging for early prediction of neoadjuvant systemic therapy response in locally advanced breast cancer patients. Conference. San Antonio Breast Cancer Symposium. ePoster, US.
2021. Understanding 90Y-Radioembolization Dosimetry – a physicist’s perspective, Society of Interventional Oncology. Invited. Understanding 90Y-Radioembolization Dosimetry – a physicist’s perspective, Society of Interventional Oncology. Online Conference, US.
2021. ACR accreditation for NM Systems, IAEA Course on Targeted Radionuclide Therapies. Invited. The University of Texas MD Anderson Cancer Center. Online Conference, US.
2021. Quantitative SPECT in Radionuclide and External Beam treatment Planning. Invited. Annual Meeting of the American Association for Physicists in Medicine, US.
2021. New SIRT Guideline Recommendations: Driving Personalized Dosimetry with SIR-Spheres 90Y-resin microspheres. Invited. GEST Sirtex Symposium. Online Conference, US.
2021. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. Invited. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. Online Conference, US.
2020. SPECT/CT imaging for Sentinel Lymph Node (SLN) mapping, EGOC-ACRIN Fall Meeting. Invited. Online Conference, US.
2020. EANM/AAPM Symposium: Quantitative SPECT – An essential tool? The Limitations and Pitfalls of Quantitative SPECT. Invited. European Association of Nuclear Medicine, Online Annual Congress, US.
2020. Y90 Radioembolization Course: Radiation Physics and Y90, Society of Interventional Oncology. Invited. Y90 Radioembolization Course: Radiation Physics and Y90, Society of Interventional Oncology. Online Conference, US.
2020. Imaging and Dosimetry for 90Y Microsphere Therapies. Invited. 2020 Spring Clinical Meeting of the American Association for Physicists in Medicine, US.
2020. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course. Invited. Society of Interventional Radiology. San Francisco, CA, US.
2019. Innovation in Hybrid Imaging: SPECT/CT Quantitation. Invited. Annual Meeting of the Radiological Society of North America. Chicago, IL, US.
2019. The Importance of Dosimetry in Radionuclide Therapy, Brazilian Medical Physics Association (ABFM). Invited. Online Annual Meeting, US.
2019. Joint AAPM.SNMMI Symposium: Image-guided 90Y-radionuclide treatment planning, delivery and verification for hepatic cancers. Invited. Annual Meeting of American Association for Physicists in Medicine. San Antonio, TX, US.
2019. Image-guided 90Y-radionuclide treatment planning, delivery and verification. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Anaheim, CA, US.
2019. SIR Connect Live – Y90 Radioembolization. Invited. Annual meeting of the Society of Interventional Radiology. Austin, TX, US.
2019. Theoretical Aspects of SPECT/CT, IAEA Regional Training Course on Targeted Radionuclide Therapy. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2019. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course. Invited. Society of Interventional Radiology. San Francisco, CA, US.
2019. Treatment Planning, IAEA Regional Training Course on Targeted Radionuclide Therapy. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2018. The 90Y-microsphere Radioembolization Program at MD Anderson Cancer Center. Invited. The Mayo Clinic at Jacksonville. Jacksonville, FL, US.
2018. Accreditation for NM Systems, IAEA-ANL Interregional Course on Targeted Radionuclide Therapies. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2018. Y-90 Therapy, IAEA-ANL Strategy Workshop on Strengthening Nuclear Medicine in Africa with Incorporated Training on Establishing Nuclear Medicine Quality Assurance Management System. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2018. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. Invited. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. La Jolla, CA, US.
2018. Dosimetry, IAEA-ANL Strategy Workshop on Strengthening Nuclear Medicine in Africa with Incorporated Training on Establishing Nuclear Medicine Quality Assurance Management System. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2017. SAM Imaging Education Course: Yttrium-90 Microsphere Therapy: Emerging Trends and Future Directions. Invited. American Association for Physicists in Medicine. Denver, CO, US.
2017. Quantitation for SPECT/CT, Categorical Course SPECT/CT: Clinical Applications and Quantification. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Denver, CO, US.
2017. Recent Advances in 90Y-microsphere Selective Internal Radiation Therapy (SIRT): Dosimetry and Response Assessment. Invited. Banner MD Anderson Cancer Center. Phoenix, AZ, US.
2017. Dosimetry and Response Assessment following 90Y-Microsphere Therapy. Invited. Arizona Chapter of the American Association for Physicists in Medicine. Phoenix, AZ, US.
2016. Planar and SPECT ACR Accreditation. Invited. IAEA Nuclear Medicine Workshop. Houston, TX, US.
2016. Recent Advances in Liver-Directed Y90 Microsphere Selective Internal Radiation Therapy (90Y-SIRT). Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. San Diego, CA, US.
2016. MBI Physicist Perspective: Advances in Instrumentation and Minimizing Patient Radiation Exposure. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. San Diego, CA, US.
2016. SPECT/CT: Basics, Quality Assurance, and Clinical Applications. Invited. 2016 Spring Clinical Meeting of the American Association for Physicists in Medicine. Salt Lake City, UT, US.
2016. Molecular Breast Imaging: History and Recent Developments. Invited. 2016 Spring Clinical Meeting of the American Association for Physicists in Medicine. Salt Lake City, UT, US.
2015. Molecular Breast Imaging: An Adjunct Diagnostic Modality for Breast Cancer Evaluation. Conference. 102nd Annual Radiological Society of North America 2015 Meeting. Chicago, IL, US.
2015. Recent Advances in SPECT/CT and PET/CT for Oncology. Invited. American Association for Physicists in Medicine. Anaheim, CA, US.
2015. Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry. Invited. American Association for Physicists in Medicine. Anaheim, CA, US.
2015. Quantitative SPECT/CT for Targeted Radionuclide Dosimetry. Invited. Delaware Valley Chapter of the American Association for Physicists in Medicine. Philadelphia, PA, US.
2015. Molecular Breast Imaging. Invited. Southwest Chapter of the American Association for Physicists in Medicine. Galveston, TX, US.
2014. Performance Evaluation of Material Decomposition with Rapid kVp-switching Dual-energy CT and Implications for Assessing Bone Mineral Density. Conference. 101st Annual Radiological Society of North America 2014 Meeting. Chicago, IL, US.
2014. SAM Imaging Education Course: Basic Principles of PET/CT, Calibration Methods and Contrast Recovery Across Multiple Cameras. Invited. 56th Annual Meeting of the American Association for Physicists in Medicine. Austin, TX, US.
2014. 90Y-microsphere Therapy Planning and Dose Calculations. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. St. Louis, MO, US.
2014. Radiobiological Modeling and Voxel-based Dosimetry for Liver-directed Yttrium-90 Microsphere Therapies. Invited. Southwest Chapter of the American Association for Physicists in Medicine. San Antonio, TX, US.
2012. SAM Imaging Symposium: Radionuclide Imaging: Yttrium-90 Microsphere Therapy Planning and Dose Calculations. Invited. 54th Annual Meeting of the American Association for Physicists in Medicine. Charlotte, NC, US.
2010. SAM Imaging Symposium: Radionuclide Imaging: SPECT/CT: Basics, Quality Assurance, and Clinical Applications. Invited. 52nd Annual Meeting of the American Association for Physicists in Medicine. Philadelphia, PA, US.
2010. Molecular Imaging-Guided Therapy: Nuclear Medicine Imaging in Yttrium-90 Microsphere Radioembolization Therapies. Invited. 57th Annual Meeting of the Society of Nuclear Medicine. Salt Lake City, UT, US.
2009. SAM Imaging Symposium: Radionuclide Imaging: SPECT/CT: Basics, Technology Updates, Quality Assurance, and Applications. Invited. 51st Annual Meeting of the American Association for Physicists in Medicine. Anaheim, CA, US.
2008. SNMTS Categorical Course, PET: Current and Upcoming Technology: Radiation Safety. Invited. 55th Annual Meeting of the Society of Nuclear Medicine. New Orleans, LA, US.
2008. SNMTS Continuing Education, Radiation Safety: Does Your Environment Get The Green Light?. Invited. 55th Annual Meeting of the Society of Nuclear Medicine. New Orleans, LA, US.
2008. Professional Symposium: ABR Examination Update. Invited. 25th Annual Meeting of the American College of Medical Physics. Seattle, WA, US.
2008. Molecular and Multimodality Imaging /Therapy: SPECT-CT: Developments in Clinical Applications. Invited. Southwest Chapter of the American Association for Physicists in Medicine. Austin, TX, US.
2007. Dual energy digital mammography for imaging calcifications. Invited. University of Washington. Seattle, WA, US.
2007. Dual energy digital mammography for imaging calcifications. Invited. Mayo Clinic. Rochester, MN, US.
2006. Dual energy digital mammography. Invited. Louisiana State University. Baton Rouge, LA, US.
2006. Developing IDL applications in Siemens e.soft environment. Conference. IDL User Group. San Diego, CA, US.

International Presentations

2024. Advancements in Yttrium-90 Therapeutic Techniques and Dosimetric Innovations. Invited. Picaso Hospital Taylor's University. Kuala Lumpur, MY.
2024. The Role of Medical Physicist in Clinical Practice and Research. Invited. University of Malaya Medical Center. Kuala Lumpur, MY.
2024. Personalized and Precise Dosimetry for SIR-Spheres Y90-resin Microspheres Resin dosimetry. Invited. Tata Memorial Hospital. Mumbai, IN.
2022. Post-treatment Imaging. Invited. Radioembolization Workshop. Utrecht, NL.
2022. Dosimetry and Yttrium-Resin Microspheres. Invited. Radioembolization Workshop. Utrecht, NL.
2019. AAPM/WMIS Joint Session: Image-Guided Cancer Therapy, The interface of molecular imaging and technology. Image-guided 90Y radio-microsphere treatment planning and delivery. Invited. World Molecular Imaging Congress. Montreal, US.
2019. NET Symposium: Advances in treatment of neuro-endocrine tumor liver metastases, Radioembolization Dosimetry. Invited. University Medical Center. Utrecht, NL.
2018. Radioembolization Dosimetry – The road towards individualized treatment planning. Invited. Dutch Nuclear Medicine Society. Kaatsheuvel, NL.
2018. Advancing SIRT Technology for the Future: The Importance of Accurate Dosimetry from Start to Finish, Annual meeting of the European Association of Nuclear Medicine. Invited. Advancing SIRT Technology for the Future: The Importance of Accurate Dosimetry from Start to Finish, Annual meeting of the European Association of Nuclear Medicine. Dusseldorf, DE.
2016. Radioembolization Dosimetry. Invited. Symposium on Advances in Nuclear Therapy, University Medical Center. Utrecht, NL.
2016. Advances in Dosimetry and Response Assessment. Invited. Holmium, the Next Generation Microspheres for Radioembolization, University Medical Hospital. Utrecht, NL.
2011. SAM Imaging Symposium: Radionuclide Imaging: Yttrium-90 Microsphere Therapy Planning and Dose Calculations. Invited. 53rd Annual Meeting of the American Association for Physicists in Medicine. Vancouver, CA.
2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Basics of SPECT/CT System. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.
2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Introduction to SPECT/CT Quality Control. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.
2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Image Reconstruction and Attenuation Correction. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.
2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Quantitative Imaging in SPECT/CT. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.

Less

Grant & Contract Support

Date:	2024 - 2025
Title:	Lung Shunt and Dose Verification Following 90Y-Microsphere Radioembolization Treatments
Funding Source:	American Association of Physicists in Medicine
Role:	Co-I

Date:	2023 - 2024
Title:	Kappadath: AAPM Travel Award
Funding Source:	American Association of Physicists in Medicine
Role:	Investigator

Date:	2023 - 2024
Title:	TriNav Infusion System for the Evaluation of Fidelity between 99m Tc-MAA and Y90-Microspheres Hepatic Distribution for Dosimetry Treatment Planning
Funding Source:	TriSalus Life Sciences
Role:	Co-PI
ID:	NCT05743842

Date:	2023 - Present
Title:	Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients with Colorectal Liver Metastases
Funding Source:	Sirtex Medical, Inc
Role:	Co-I

Date:	2022 - 2023
Title:	Evaluation of novel MBI tumor uptake metric, SUVb, for predicting tumor response in breast cancer patients
Funding Source:	MDACC-QIAC Grant
Role:	Co-PI

Date:	2022 - 2027
Title:	Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology
Funding Source:	NIH/NCI
Role:	Co-Mentor
ID:	5T32CA196561-08

Date:	2021 - 2023
Title:	Novel PET Imaging to Guide Yttrium-90 Radioembolization Therapy in Hepatocellular Carcinoma
Funding Source:	MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma
Role:	Co-I
ID:	P50CA217674

Date:	2021 - 2026
Title:	InHANCE: Imaging Innovation for Head And Neck Cancer Evaluation & Treatment Delivery
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1P01CA254866-01A1

Date:	2021 - 2025
Title:	A prospective, multicenter, open-label single arm study evaluating the safety and efficacy of selective internal radiation therapy (SIRT) using SIR-Spheres® Y-90 resin microspheres on duration of response (DoR) and objective response rate (ORR) in unresectable hepatocellular carcinoma (HCC) patients
Funding Source:	Sirtex Medical, Inc
Role:	PI
ID:	NCT04736121

Date:	2020 - 2021
Title:	WS#29 Establish the minimum detectable PET activity concentrations when imaging F-18 and Ga-68 labeled prostate cancer radiotracers with the Sigma PET/MR
Funding Source:	GE Healthcare
Role:	PI
ID:	00058508

Date:	2020 - 2022
Title:	Enhanced selective internal radiation therapy based on remote control of individual radiation sources
Funding Source:	NIH/NCI
Role:	Co-I
ID:	1 R21 CA241837-01A1

Date:	2020 - 2023
Title:	Evaluation of the distribution of radiopaque non-radioactive (EYE90) 90Y-radioembolic microsphere in liver and kidneys in a swine model
Funding Source:	ABK Biomedical
Role:	PI
ID:	#57397

Date:	2020 - 2027
Title:	A Phase 1 open-label, first-in-human, multi-center study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity of thorium-227 labeled antibodychelator conjugate BAY 2701439, in participants with advanced HER2-expressing tumors
Funding Source:	BAYER HEALTHCARE PHARMACEUTICALS
Role:	Co-I
ID:	2019-0771

Date:	2019 - 2026
Title:	An Open-Label, First-In-Human, Multi-Center Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Anti-Tumor Activity of A Thorium-227 Labeled Antibody-Chelator Conjugate, BAY 2287411 Injection, In Patients with Solid Tumors Known To Express Mesothelin
Funding Source:	BAYER HEALTHCARE PHARMACEUTICALS
Role:	Co-I
ID:	2019-0363

Date:	2019 - 2024
Title:	Radioembolization for HCC Patients with Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D)
Funding Source:	Boston Scientific BTG
Role:	Co-PI
ID:	NCT03896646

Date:	2017 - 2020
Title:	NCT03295006 - A TheraSphere Advanced Dosimetry Retrospective Global Evaluation in Hepatocellular Carcinoma Treatment (TARGET)
Funding Source:	BTG International Inc
Role:	PI

Date:	2016 - 2019
Title:	NCT03188328- A dose escalation study to evaluate safety, tolerability, pharmacokinetics, dosimetry, maximum tolerated dose and preliminary efficacy of intra-lesionally injected AvidinOX, followed by systemic IV administration of escalating doses of [177Lu]DOTA-biotin in patients with solid tumors or lymphomas with injectable neoplastic lesions
Funding Source:	Sigma Tau
Role:	Co-I
ID:	2016-0262

Date:	2016 - 2019
Title:	NCT03028311 - Feasibility of Single Session In-Room Yttrium-90 Radioembolization Diagnostic Angiography and Treatment
Funding Source:	SIRTEX Medical Limited
Role:	Co-PI
ID:	13015485-V101

Date:	2016 - 2020
Title:	In Vivo Molecular Breast Imaging with Tc‐99m Sestamibi for the Prediction of Multidrug Resistance in Triple Negative Breast Cancers
Funding Source:	MDACC/GE Healthcare CABI MI2
Role:	Co-I

Date:	2015 - 2019
Title:	Quantitative 99mTc-Sestamibi Molecular Breast Imaging (MBI) using GE Discovery NM750b
Funding Source:	GE-CABI, General Electric
Role:	PI

Date:	2014 - 2019
Title:	Quantitative 90Y PET/CT: Quest Site Assessment Study
Funding Source:	SIRTEX Medical Limited
Role:	PI

Date:	2013 - 2015
Title:	Radiation dose reduction by combining contrast-enhanced diagnostic CT examinations with 99mTc-MDP SPECT examinations using dual-modality SPECT/CT
Funding Source:	MDACC Institutional Research Grant
Role:	PI
ID:	FRED#34737

Date:	2013 - 2014
Title:	Develop methodology to separately compute the trabecular and cortical bone-mineral density using the GE Discovery CT 750HD scanner with GSI
Funding Source:	General Electric
Role:	PI
ID:	GE-CABI

Date:	2012 - 2016
Title:	A novel dose calculation method for targeted radionuclide therapy
Funding Source:	Christiana Care Health Services/NIH
Role:	PI
ID:	R01-CA13896-02, (Sub-award No. 601889)

Date:	2012 - 2013
Title:	Optimization of the Yttrium-90 bremsstrahlung SPECT/CT for SymbiaT SPECT/CT scanners
Funding Source:	Siemens Medical Solutions
Role:	PI

Date:	2012 - 2017
Title:	Multi-modal reconstruction and quantitative SPECT imaging
Funding Source:	Siemens Medical Solutions
Role:	Co-I
ID:	LS2012-00036240LG-03

Date:	2011 - 2016
Title:	Reporter-based stem cell imaging and therapy
Funding Source:	NIH
Role:	Co-I
ID:	1-R01-CA138386

Date:	2009 - 2012
Title:	Quantitative 90Y bremsstrahlung SPECT/CT to estimate tumor radiation dose in vivo
Funding Source:	NIH/NCI
Role:	PI
ID:	R01-CA149133

Date:	2002 - 2006
Title:	aSi/CsI FP digital chest imaging with scatter rejection and exposure equalization
Funding Source:	NIH/NIBIB
Role:	Co-I
ID:	EB000117

Date:	2000 - 2004
Title:	Dual-Energy Digital Mammography
Funding Source:	United States Army Breast Cancer Research Program
Role:	Co-I
ID:	DAMO17-00-1-0316

CV information above last modified June 27, 2025

S. Cheenu Kappadath, Ph.D.

About Dr. S. Cheenu Kappadath

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S. Cheenu Kappadath, Ph.D.

About Dr. S. Cheenu Kappadath

Present Title & Affiliation

Primary Appointment

Research Interests

Clinical Interests

Education & Training

Degree-Granting Education

Postgraduate Training

Board Certifications

Experience & Service

Academic Appointments

Administrative Appointments/Responsibilities

Other Appointments/Responsibilities

Institutional Committee Activities

Honors & Awards

Professional Memberships

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Peer-Reviewed Articles

Invited Articles

Manuals, Teaching Aids, Other Teaching Publications

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Regional Presentations

National Presentations

International Presentations

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