S. Cheenu Kappadath, Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
About Dr. S. Cheenu Kappadath
S. Cheenu Kappadath, Ph.D., is a Professor in the Department of Imaging Physics. He is a board-certified and licensed medical physicist with specialties in Nuclear Medicine Physics and Instrumentation (ABSNM) and Diagnostic Radiologic Physics (ABR). He provides clinical physics support for the Departments of Nuclear Medicine and Diagnostic Radiology in the Division of Diagnostic Imaging. He is the Program Director for Imaging Physics Network Services and oversees clinical Imaging Physics operations at institutions within the MD Anderson Cancer Network as well as other satellite and regional care facilities.
He is actively involved in a variety of funded research projects in SPECT/CT, PET/CT, and CT and is the recipient of grants from NIH and industry. Topics of research focus include liver-directed Yttrium-90 microsphere therapy, molecular breast imaging, quantitative imaging with SPECT, PET, and CT; and patient-specific voxel dosimetry. Dr. Kappadath also holds a joint Associate Faculty appointment at The University of Texas Graduate School of Biomedical Sciences in Houston where he serves as an instructor in various courses and advisor to medical physics graduate students. Dr. Kappadath is an active member of several professional medical physics societies such as the AAPM, SNMMI, and ACR. More recently, his research has received the Arthur Weis Award in Radiation Dosimetry and Safety from the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
Present Title & Affiliation
Primary Appointment
Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, Image Guided Cancer Therapy (IGCT) Program, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, Cancer Core Support Grant - Radiation Oncology Cancer Imaging (ROCIP) Program, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, Image Guided Cancer Therapy (IGCT) Program, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, Cancer Core Support Grant - Radiation Oncology Cancer Imaging (ROCIP) Program, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | University of New Hampshire, Durham, New Hampshire, US, Physics, Ph.D |
| 1994 | University of New Hampshire, Durham, New Hampshire, US, Physics, M.S |
| 1991 | Illinois Wesleyan University, Bloomington, Illinois, US, Physics and Mathematics, BA |
Board Certifications
| 2008 | American Board of Radiology, Diagnostic Medical Physics |
| 2007 | American Board of Science in Nuclear Medicine, Nuclear Medicine Physics and Instrumentation |
Experience & Service
Administrative Appointments/Responsibilities
Clinical Coordinator, Nuclear Medicine Physics, Imaging Physics Residency Program, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Member, Merit and FRP Committee, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Program Director, Imaging Physics Network Services, Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - Present
Member, Imaging Physics Clinical Operations Committee, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2015
Member, Nuclear Medicine Research Peer-Review Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - Present
Other Appointments/Responsibilities
Coordinator, Outreach Clinical Physics Operations, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2015
Clinical Consultant, MD Anderson Cancer Network, Houston, TX, 2011 - Present
Lead Imaging Physicist, Banner MD Anderson Cancer Center, Phoenix, AZ, 2011 - 2013
Institutional Committee Activities
Member, Institutional Review Board (IRB), 2023 - Present
Member, Faculty Academic Review Committee (FARC), 2015 - 2018
Departmental Representative, Faculty Appeals Committee (FAC), 2014 - 2018
Honors & Awards
| 2024 | AAPM Travel Award, Global Research and Education Mentoring Program, American Association for Physicists in Medicine |
| 2023 | Best in Physics Award (Imaging), Lopez BL, Rauch GM, Kappadath SC. Absolute 99mTc-Sestamibi Breast Uptake in HER2-, HER2+, and TNBC Patients Undergoing Neoadjuvant Chemotherapy, American Association of Physicists in Medicine (AAPM) Annual Meeting |
| 2023 | Clinical Research Award, Division of Diagnostic Imaging, UT MD Anderson Cancer Center |
| 2023 | Best Presentation at GEST – 3rd Place, Radioembolization for HCC patients with personalized Yttrium-90 dosimetry for curative intent (RAPY90D), Mahvash A, Henry C, Lopez B, Abdelsalam M, Chasen B, Kuban J, Metwalli Z, Odisio B, Habibollahi P, Murthy R, Kaseb A, Kappadath SC, Global Embolization Symposium and Technologies (GEST) Annual Meeting |
| 2023 | Top 2022 Scientific Paper Award in EJNMMI Physics, Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model – Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon AC, Bryan JN, Maitz C, Abraham R, Kappadath SC, Syme A, European Journal of Nuclear Medicine and Molecular Imaging Physics |
| 2023 | AAPM Mentor Award, Global Research and Education Mentoring Program, American Association for Physicists in Medicine (AAPM) |
| 2022 | Best in Physics Award (Therapy), Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon A, Bryan J, Maitz C, Abraham R, Kappadath SC, Syme A. Precision Dosimetry in Yttrium-90 Radioembolization Through CT Imaging of Radiopaque Microspheres in a Rabbit Liver Model, American Association for Physicists in Medicine (AAPM) Annual Meeting |
| 2019 | Fellow, American Association for Physicists in Medicine |
| 2019 | President’s Recognition of Faculty Excellence Award, UT MD Anderson Cancer Center |
| 2019 - 2022 | Multi-Year Clinical Faculty Appointment Award, UT MD Anderson Cancer Center |
| 2018 | 1st Place Award Data Science and Instrumentation Track Poster Award, Lopez B, Balagopal A, Mahvash A, Kappadath SC. Evaluation of Errors in Common Lung Mass Estimation Methods used for Lung Mean Dose (LMD) Calculation in 90Y-Microsphere Therapy Planning, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting |
| 2018 | Finalist, Young Investigator Symposium, Lopez B, Mahvash A, Kappadath SC. Novel SPECT/CT-Based Lung Dose Calculation for Treatment Planning in 90Y-Microsphere Radioembolization Therapy, American Association for Physicists in Medicine (AAPM) Annual Meeting |
| 2016 | Aaron Blanchard Research Award for best dissertation in Medical Physics by mentee Justin Mikell, Voxel-level absorbed dose calculations with a deterministic grid-based Boltzmann solver for nuclear medicine and the clinical value of voxel-level calculations, UT Health Graduate School of Biomedical Sciences MD Anderson Cancer Center, Houston, Texas |
| 2015 | Arthur Weis Award in Radiation Dosimetry and Safety, Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Biases and variability in partition model absorbed doses following Y90 microsphere therapy, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting |
| 2015 | 3rd Place Award Oncology Clinical Diagnosis Track Poster Presentation, Mikell J, Mahvash A, Siman W, Mourtada F, Kappadath SC. Biases and variability in partition model absorbed doses following Y90 microsphere therapy, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting |
| 2014 | Volunteer Service Award, American Board of Radiology |
| 2012 | 2nd Place Award Radiopharmacy Track Poster Presentation, Maclellan C, Hobbs BP, Chasen B, Murthy R, Mahvash A, Kappadath SC. Absorbed dose differences in 90Y microsphere therapy between pre-treatment 99mTc-MAA and post-treatment 90Y scans, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting |
| 2012 | 2nd Place Award Technologist Oral Presentation, Gonzalez JA, McCoy AP, Mar MV, Kappadath SC. Identifying optimal SPECT acquisition for liver imaging using 99mTc-MAA, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting |
| 2012 | 2nd Place Molecular Targeting Probes Track Poster Award, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting |
| 2008 | American Board of Radiology Certification in Diagnostic Radiologic Physics |
| 2007 | Reviewer's Choice Oral Presentation Award, Kappadath SC, Wendt RE. Assessment of the radiation shielding for a busy PET/CT facility, American Association for Physicists in Medicine (AAPM) Annual Meeting |
| 2007 | Trainee Travel Grant Recipient, IEEE Medical Imaging Annual Conference, Honolulu, Hawaii |
| 2007 | American Board of Science in Nuclear Medicine Certification in Nuclear Medicine Physics and Instrumentation |
| 2006 - 2008 | Medical Physics Residency Award, Radiological Society of North America |
| 2004 | Honorable Mention Poster Award, Kappadath SC, Shaw C, Lai CJ, Liu X, Whitman G., Dual-energy digital mammography for calcification imaging: theory and implementation, SPIE Physics of Medical Imaging Symposium |
| 1991 | Meritorious Award, Mathematical Contest in Modeling, Illinois Wesleyan University, Bloomington, Illinois |
| 1991 | Cum laude, B.A, Illinois Wesleyan University, Bloomington, Illinois |
| 1987 - 1991 | Scholarship Award, Illinois Wesleyan University, Bloomington, Illinois |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Lam, MG, Garin, E, Haste, P, Denys, A, Geller, BS, Kappadath, SC, Turkmen, C, Sze, DY, Alsuhaibani, H, Herrmann, K, MacCauro, M, Cantasdemir, M, Dreher, MR, Fowers, K, Gates, VL, Salem, R. Utility of pre-procedural [99mTc]TcMAA SPECT/CT Multicompartment Dosimetry for Treatment Planning of 90Y Glass microspheres in patients with Hepatocellular Carcinoma. European Journal of Nuclear Medicine and Molecular Imaging 52(2):744-755, 2025. e-Pub 2025. PMID: 39331131.
- Abraham RJ, Arepally A, Liu D, Lewandowski R, Kappadath SC, Verma A, Dobrowski D, Holden A. Imageable Radioembolization Microspheres for Treatment of Unresectable Hepatocellular Carcinoma: Interim Results from a First-in-Human Trial. J Vasc Interv Radiol 35(10):1464-1473.e1, 2024. e-Pub 2024. PMID: 38944236.
- Gonzalez F, Scott PJH, Jeffers CD, Kappadath SC. SNMMI Clinical Trials Network Research Series for Technologists: An Introduction to Conducting Theranostic Clinical Trials. J Nucl Med Technol 52(3):184-191, 2024. e-Pub 2024. PMID: 39237336.
- Lopez BP, Kappadath SC. (90)Y SIR-Spheres Activity Measurement with New SIROS D-Vial Delivery Kit. J Nucl Med Technol 52(3):256-260, 2024. e-Pub 2024. PMID: 39019573.
- Kokabi N, Webster LA, Dabbous H, Shah A, Brandon D, Galt J, Xing M, Villalobos A, Davarpanahfakhr A, Kappadath SC, Schuster DM. Resin-Based 90 Y Tumor Dose as a Predictor of Duration of Response and Survival in Patients With Surgically Unresectable Hepatocellular Carcinoma : A Prospective Single-Arm Study. Clin Nucl Med 49(9):799-805, 2024. e-Pub 2024. PMID: 38861361.
- Kappadath SC, Henry EC, Lopez BP, Mahvash A. Quantitative evaluation of (90)Y-PET/CT and (90)Y-SPECT/CT-based dosimetry following Yttrium-90 radioembolization. Med Phys 51(9):6061-6074, 2024. e-Pub 2024. PMID: 38781554.
- Henry EC, Mahvash A, Lopez BP, Kappadath SC. A comparison of methods for in vivo activity and absorbed dose quantification with PET/CT following yttrium-90 radioembolization. Med Phys 51(9):6034-6045, 2024. e-Pub 2024. PMID: 38772046.
- Lam MGEH, Kappadath SC. Need for a Practical Dosimetry Paradigm That Incorporates Dose Heterogeneity. J Vasc Interv Radiol 35(6):919-921, 2024. e-Pub 2024. PMID: 38432473.
- Keane G, van Rooij R, Lam M, Kappadath SC, Kovan B, Leon S, Dreher M, Fowers K, de Jong H. An international phantom study of inter-site variability in Technetium-99m image quantification: analyses from the TARGET radioembolization study. EJNMMI Phys 11(1):46, 2024. e-Pub 2024. PMID: 38809320.
- Kappadath SC. Retrospective dosimetry for yttrium-90 radioembolization with resin microspheres. J Vasc interv Radiol 35(5):709-711, doi:10.1016/j.jvir.2024.01.013, 2024. e-Pub 2024.
- Henry EC, Lopez B, Mahvash A, Thomas MA, Kappadath SC. Predicting the net administered activity in 90 Y-radioembolization patients from post-procedure 90 Y-SPECT/CT. Med Phys 50(11):7003-7015, 2023. e-Pub 2023. PMID: 37272198.
- Lopez BP, Kappadath SC. Monte Carlo-derived 99m Tc uptake quantification with commercial planar MBI: Tumor and breast activity concentrations. Med Phys 50(5):2985-2997, 2023. e-Pub 2023. PMID: 36625713.
- Kokabi N, Arndt-Webster L, Chen B, Brandon D, Sethi I, Davarpanahfakhr A, Galt J, Elsayed M, Bercu Z, Cristescu M, Kappadath SC, Schuster DM. Voxel-based dosimetry predicting treatment response and related toxicity in HCC patients treated with resin-based Y90 radioembolization: a prospective, single-arm study. Eur J Nucl Med Mol Imaging 50(6):1743-1752, 2023. e-Pub 2023. PMID: 36650357.
- Kappadath SC, Lopez BP. Single-Compartment Dose Prescriptions for Ablative 90Y-Radioembolization Segmentectomy. Life (Basel) 13(6), 2023. e-Pub 2023. PMID: 37374021.
- Lopez BP, Kappadath SC. Monte Carlo-derived 99m Tc uptake quantification with commercial planar MBI: Absolute tumor activity. Med Phys 50(5):2985-2997, 2023. e-Pub 2023. PMID: 36583691.
- Salem R, Padia SA, Lam M, Chiesa C, Haste P, Sangro B, Toskich B, Fowers K, Herman JM, Kappadath SC, Leung T, Sze DY, Kim E, Garin E. Clinical, dosimetric, and reporting considerations for Y-90 glass microspheres in hepatocellular carcinoma: updated 2022 recommendations from an international multidisciplinary working group. Eur J Nucl Med Mol Imaging 50(2):328-343, 2023. e-Pub 2023. PMID: 36114872.
- Lam M, Garin E, Palard-Novello X, Mahvash A, Kappadath SC, Haste P, Tann M, Herrmann K, Barbato F, Geller B, Schaefer N, Denys A, Dreher M, Fowers KD, Gates V, Salem R. Direct comparison and reproducibility of two segmentation methods for multicompartment dosimetry: round robin study on radioembolization treatment planning in hepatocellular carcinoma. Eur J Nucl Med Mol Imaging 51(1):245-257, 2023. e-Pub 2023. PMID: 37698645.
- Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon AC, Bryan JN, Maitz C, Karnia JJ, Abraham R, Kappadath SC, Syme A. Correction: Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model. EJNMMI Phys 10(1):74, 2023. e-Pub 2023. PMID: 38017227.
- Lopez BP, Mahvash A, Long JP, MGEH L, Kappadath SC. Factors modulating 99mTc-MAA planar lung dosimetry for 90Y-radioembolization. J Appl Clin Med Phys 23(12):e13734, 2022. e-Pub 2022. PMID: 35906892.
- Kokabi N, Webster LA, Elsayed M, Switchenko JM, Chen B, Brandon D, Galt J, Sethi I, Cristescu M, Kappadath SC, Schuster DM. Accuracy and Safety of Scout Dose Resin Yttrium-90 Microspheres for Radioembolization Therapy Treatment Planning: A Prospective Single-Arm Clinical Trial. J Vasc Interv Radiol 33(12):1578-1587.e5, 2022. e-Pub 2022. PMID: 36075560.
- Hruska, CB, Corion, C, de Geus-Oei, LF, Adrada, BE, Fowler, AM, Hunt, KN, Kappadath, SC, Pilkington, P, Pereira Arias-Bouda, LM, Rauch, GM. SNMMI Procedure Standard/EANM Practice Guideline for Molecular Breast Imaging with Dedicated g-Cameras. Journal of nuclear medicine technology 50(2):103-110, 2022. e-Pub 2022. PMID: 40168518.
- Henry EC, Strugari M, Mawko G, Brewer K, Liu D, Gordon AC, Bryan JN, Maitz C, Abraham R, Kappadath SC, Syme A. Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model. EJNMMI Phys 9(1):21, 2022. e-Pub 2022. PMID: 35312882.
- Lam M, Garin E, Maccauro M, Kappadath SC, Sze DY, Turkmen C, Cantasdemir M, Haste P, Herrmann K, Alsuhaibani HS, Dreher M, Fowers KD, Salem R. A global evaluation of advanced dosimetry in transarterial radioembolization of hepatocellular carcinoma with Yttrium-90: the TARGET study. Eur J Nucl Med Mol Imaging 49(10):3340-3352, 2022. e-Pub 2022. PMID: 35394152.
- Sharma NK, Kappadath SC, Chuong M, Folkert M, Gibbs P, Jabbour SK, Jeyarajah DR, Kennedy A, Liu D, Meyer JE, Mikell J, Patel RS, Yang G, Mourtada F. The American Brachytherapy Society consensus statement for permanent implant brachytherapy using Yttrium-90 microsphere radioembolization for liver tumors. Brachytherapy 21(5):569-591, 2022. e-Pub 2022. PMID: 35599080.
- Lopez BP, Rauch GM, Adrada B, Kappadath SC. Functional tumor diameter measurement with molecular breast imaging: development and clinical application. Biomed Phys Eng Express 8(5), 2022. e-Pub 2022. PMID: 35917778.
- Kappadath SC, Lopez BP. Organ-level internal dosimetry for intra-hepatic-arterial administration of 99mTc-macroaggregated albumin. Med Phys 49(8):5504-5512, 2022. e-Pub 2022. PMID: 35612924.
- Mahvash A, Chartier S, Turco M, Habib P, Griffith S, Brown S, Kappadath SC. A prospective, multicenter, open-label, single-arm clinical trial design to evaluate the safety and efficacy of 90Y resin microspheres for the treatment of unresectable HCC: the DOORwaY90 (Duration Of Objective Response with arterial Ytrrium-90) study. BMC Gastroenterol 22(1):151, 2022. e-Pub 2022. PMID: 35346070.
- Kairemo K, Kangasmäki A, Kappadath SC, Joensuu T, Macapinlac HA. A retrospective comparative study of sodium fluoride Na18F-PET/CT and 68Ga-PSMA-11 PET/CT in the bone metastases of prostate cancer using a volumetric 3-D radiomic analysis. Life 12(12):1977, 2022. e-Pub 2022. PMID: 36556342.
- Broyles JM, Smith JM, Wong FC, Hanasono MM, El C, Kappadath SC, Schaverien MV. Single-photon emission computed tomographic reverse lymphatic mapping for groin vascularized lymph node transplant planning. Plast Reconstr Surg 150(4):869e-879e, 2022. e-Pub 2022. PMID: 35939631.
- Hruska CB, Corion C, de Geus-Oei LF, Adrada BE, Fowler AM, Hunt KN, Kappadath SC, Pilkington P, Arias-Bouda LMP, Rauch GM. SNMMI procedure standard/EANM practice guideline for molecular breast imaging with dedicated gamma cameras. J Nucl Med Technol 50(2):103-110, 2022. e-Pub 2022.
- Teyateeti, A, Mahvash, A, Long, JP, Abdelsalam, ME, Avritscher, R, Kaseb, A, Odisio, BC, Ravizzini, G, Surasi, DS, Teyateeti, A, Macapinlac, HA, Kappadath, SC. Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib. World journal of gastroenterology 27(47):8166-8181, 2021. e-Pub 2021. PMID: 35068861.
- Kairemo, K, Jessop, A, Vija, A, Ding, X, Spence, D, Kappadath, SC, Macapinlac, HA. A prospective comparative study of using ultrasonography, 4d-ct and parathyroid dual-phase scintigraphy with spect in patients with primary hyperparathyroidism. Diagnostics 11(11), 2021. e-Pub 2021. PMID: 34829354.
- Lopez, BP, Guan, F, Rauch, GM, Kappadath, SC. Monte Carlo simulation of pixelated CZT detector with Geant4. Physics in medicine and biology 66(12), 2021. e-Pub 2021. PMID: 34038878.
- Henry, EC, Strugari, M, Mawko, G, Brewer, KD, Abraham, R, Kappadath, SC, Syme, A. Post-administration dosimetry in yttrium-90 radioembolization through micro-CT imaging of radiopaque microspheres in a porcine renal model. Physics in medicine and biology 66(9), 2021. e-Pub 2021. PMID: 33784639.
- Levillain, H, Bagni, O, Deroose, CM, Dieudonné, A, Gnesin, S, Großer, OS, Kappadath, SC, Kennedy, A, Kokabi, N, Liu, D, Madoff, DC, Mahvash, A, Martinez de la Cuesta, A, Ng, DC, Paprottka, PM, Pettinato, C, Rodriguez-Fraile, M, Salem, R, Sangro, B, Strigari, L, Sze, DY, de Wit van der veen, BJ, Flamen, P. International recommendations for personalized selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres. European Journal of Nuclear Medicine and Molecular Imaging 48(5):1570-1584, 2021. e-Pub 2021. PMID: 33433699.
- Levillain H, Bagni O, Deroose CM, Dieudonne A, Gnessin S, Grosser OS, Kappadath SC, Kennedy A, Kokabi N, Liu DM, Madoff DC, Mahvash A, Martinez A, Ng D, Paprottka P, Pettinato C, Rodríguez-Fraile M, Salem R, Sangro B, Strigari L, Sze DY, de Wit B, Flamer P. International recommendations for personalized selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres. Eur J Nucl Med Mol Imaging 48:1570–1584, 2021. e-Pub 2021.
- Kappadath SC, Lopez BP, Salem R, MGEH L. Lung shunt and lung dose calculation methods for radioembolization treatment planning. Q J Nucl Med Mol Imaging 65(1):32-42, 2021. e-Pub 2021.
- Lopez BP, Guan F, Rauch GM, Kappadath SC. Monte Carlo simulation of pixelated CZT detector with Geant4: validation of clinical molecular breast imaging system. Phys Med Biol 66:125009, 2021. e-Pub 2021.
- Kappadath SC, Lopez BP, Salem R, MGEH L. Reassessment of the lung dose limits for radioembolization. Nucl Med Comm 42:1064–1075, 2021. e-Pub 2021.
- Henry EC, Strugari M, Mawko G, Brewer KD, Abraham R, Kappadath SC, Syme A. Post-administration dosimetry in yttrium-90 radioembolization through micro-CT imaging of radiopaque microspheres in a porcine renal model. Phys Med Biol 66:095011, 2021. e-Pub 2021.
- Kaseb AO, Kappadath SC, Lee SS, Raghav KP, Mohamed YI, Xiao L, Morris JS, Ohaji C, Avritscher R, Odisio BC, Kuban J, Abdelsalam ME, Chasen B, Elsayes KM, Elbanan M, Wolff RA, Yao JC, Mahvash A. A prospective phase II study of safety and efficacy of sorafenib followed by 90Y glass microspheres for patients with advanced or metastatic hepatocellular carcinoma. J Hepatocell Carcinoma 8:1129-1145, 2021. e-Pub 2021.
- Kairemo K, Jessop AC, Vija AH, Ding X, Spence D, Kappadath SC, Macapinlac HA. A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism. Diagnostics 11(11):2006, 2021. e-Pub 2021.
- Teyatteti A, Mahvash A, Long J, Abdelsalam M, Avritscher R, Kaseb A, Odisio B, Ravizzini G, Surasi D, Teyatteti A, Macapinlac H, Kappadath SC. Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib. World J Gastroenterol 27(47):8166-8181, 2021. e-Pub 2021.
- Kairemo K, Kappadath SC, Joensuu T, Macapinlac HA. A Retrospective Comparative Study of Sodium Fluoride (NaF-18)-PET/CT and Fluorocholine (F-18-CH) PET/CT in the Evaluation of Skeletal Metastases in Metastatic Prostate Cancer Using a Volumetric 3-D Radiomics Analysis. Diagnostics (Basel) 11(1):17, 2021. e-Pub 2021. PMID: 33374148.
Other Articles
- Kappadath, SC Retrospective Dosimetry for Yttrium-90 Radioembolization with Resin Microspheres. Journal of Vascular and Interventional Radiology 35(5):709-711, 2024. PMID: 38663954.
- Kappadath, SC, Lopez, BP, Salem, R, Lam, MG lung shunt and lung dose calculation methods for radioembolization treatment planning. Quarterly Journal of Nuclear Medicine and Molecular Imaging 65(1):32-42, 2021. PMID: 33393753.
Selected Presentations & Talks
Local Presentations
- 2024. Emerging Technologies and Technical Advances for Liver. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2022. 90Y-Radioembolization: Current status on dosimetry and clinical evidence. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2021. Updates on 90Y-Radioembolization Dosimetry and Dose-Response, Theranostics: Current Status and Emerging Opportunities at MD Anderson. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2019. Image-guided Radionuclide Therapy Dosimetry, Symposium on Cancer Theranostics and Molecular Imaging. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2016. Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry. Invited. UT Medical School. Houston, TX, US.
- 2015. Liver Directed Interventional Therapies and Dosimetric Considerations. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2015. Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2015. Molecular Breast Imaging. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2014. Recent Advances in PET/CT. Conference. Memorial Hermann Northwest Hospital. Houston, TX, US.
- 2014. Improving Response Modeling for Hepatocellular Carcinoma Treated with Radioactive 90Y Microspheres through Quantitative 90Y Bremsstrahlung SPECT/CT and Voxel-based Dosimetry. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2014. Deadtime Count-Loss Compensation for Quantitative SPECT/CT Imaging. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2014. Recent Developments in Quantitative Nuclear Medicine Imaging and Dosimetry. Invited. Rice University. Houston, TX, US.
- 2012. Computed Tomography: Image Quality and Dosimetry. Conference. Memorial Hermann Northwest Hospital. Houston, TX, US.
- 2011. Yttrium-90 Microsphere Therapy Planning and Dose Calculations. Conference. Memorial Hermann Northwest Hospital. Houston, TX, US.
- 2010. NM ACR Accreditation. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2010. SPECT/CT: Fundamentals and Clinical Applications. Conference. Memorial Herman Northwest Hospital. Houston, TX, US.
- 2009. TherasphereY90-microsphere Therapy Planning and Dose Calculations. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2007. An analysis of high-energy gamma-ray images acquired on a conventional gamma camera with coded apertures. Conference. 24th Annual Meeting of the Houston Society for Engineering in Medicine and Biology. Houston, TX, US.
- 2006. Developing IDL applications in Siemens e.soft environment. Conference. IDL Medical User Group. Houston, TX, US.
- 2004. Digital X-Ray Imaging Research. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
Regional Presentations
- 2022. Quantitative SPECT for Radiopharmaceutical and External Beam Treatment Planning. Conference. Health Physics Society State of Texas Chapter. Online Conference, US.
National Presentations
- 2024. Summary of Recent Clinical Evidence and Treatment Scenarios with 90Y-Radioembolization. Invited. 66th Annual Association of Physicists in Medicine. Los Angeles, CA, US.
- 2024. Advanced Concepts in Lung and Liver Dosimetry for 90Y-Radioembolization. Invited. 66th Annual Association of Physicists in Medicine. Los Angeles, CA, US.
- 2024. Dosimetry Principles of Glass and Resin Microspheres. Invited. Y-90 Master Class. Chicago, IL, US.
- 2024. Review of NRC Safety Events in Radioembolization. Invited. Y-90 Master Class. Chicago, IL, US.
- 2024. Medical Physics Research Mentorship and Expanding Global Opportunities: From Insights to Impact. Invited. American Association for Physicists in Medicine, US.
- 2024. Must-Know Studies for MDT Tumor Board - DOSISPHERE. Invited. Society of Interventional Oncology. Long Beach, CA, US.
- 2024. Eye90 microspheres for the treatment of unresectable HCC. Invited. Society of Interventional Oncology. Long Beach, CA, US.
- 2023. 90Y-Microsphere Therapy: Dosimetry and Clinical Outcomes. Invited. Arizona Chapter of the American Association for Physicists in Medicine. Phoenix, AZ, US.
- 2023. Dosimetric Considerations in Heavily Treated Patients and Other Challenging Scenarios, Society of Interventional Oncology Symposium: Y90-radioembolization and Immunotherapy. Invited. Online Conference, US.
- 2023. NM Therapy and Dosimetry for Liver Tumors. Invited. IAEA Course on Targeted Radionuclide Therapies. Houston, TX, US.
- 2023. Dosimetry Principles with Resin 90Y-Microspheres. Invited. Y-90 Master Class. Chicago, IL, US.
- 2023. Dosimetry with SIR-Spheres Y-90 resin microspheres. Invited. Sirtex Medical. Webinar, US.
- 2023. How to Get Reimbursed for Pre- and Post-Treatment Dosimetry. Invited. Y-90 Master Class. Chicago, IL, US.
- 2023. Dosimetry Principles with Glass 90Y-Microspheres. Invited. Y-90 Master Class. Chicago, IL, US.
- 2023. Radioembolization for HCC patients with personalized Yttrium-90 dosimetry for curative intent (RAPY90D). Conference. GEST Annual Meeting. New York City, NY, US.
- 2023. Winfield Evan Lectureship: Advanced Dosimetry for 90Y-Microsphere Therapies. Invited. Southwest Chapter of the Society of Nuclear Medicine and Molecular Imaging (SWC-SNMMI). Sugarland, TX, US.
- 2023. A prospective, multicenter, open-label,clinical trial design to evaluate the safety and efficacy of Y90 resin microspheres for treatment of unresectable hepatocellular carcinoma (HCC): Duration Of Objective Response with arterial Yttrium-90 (DOORwaY90). Conference. TAG HCC Annual Meeting. Huntington, CA, US.
- 2023. Y90 Radioembolization for Primary & Metastatic Liver Cancer: One Size Does Not Fit All. Invited. Society of Interventional Oncology. Washington, DC, US.
- 2023. Resin Y-90 Dosimetry: From Theory to Practice. Invited. Society of Interventional Oncology. Washington, DC, US.
- 2022. Physics Theory, Y90 The Complete Course. Invited. Society of Interventional Radiology. San Diego, CA, US.
- 2022. Imaging for Radiation Therapy: Challenges and Solutions. Invited. AAPM Joint Imaging-Therapy Educational SAM Course. Washington, TX, US.
- 2022. 90Y-radioembolization dosimetry treatment planning. Invited. Nuclear Medicine Physicists Association of India. Online Conference, US.
- 2022. 99mTc-MAA Shunt Study: Determining Tumor to Normal Liver Perfusion Ratio, Y-90 Master Class. Invited. Society of Interventional Oncology. San Francisco, CA, US.
- 2022. 90Y-resin dosimetry: Optimization of Tumor and Liver Parenchyma Dose, Y-90 Master Class. Invited. Society of Interventional Oncology. San Francisco, CA, US.
- 2021. Quantitative Molecular Breast Imaging for early prediction of neoadjuvant systemic therapy response in locally advanced breast cancer patients. Conference. San Antonio Breast Cancer Symposium. ePoster, US.
- 2021. Understanding 90Y-Radioembolization Dosimetry – a physicist’s perspective, Society of Interventional Oncology. Invited. Understanding 90Y-Radioembolization Dosimetry – a physicist’s perspective, Society of Interventional Oncology. Online Conference, US.
- 2021. ACR accreditation for NM Systems, IAEA Course on Targeted Radionuclide Therapies. Invited. The University of Texas MD Anderson Cancer Center. Online Conference, US.
- 2021. Quantitative SPECT in Radionuclide and External Beam treatment Planning. Invited. Annual Meeting of the American Association for Physicists in Medicine, US.
- 2021. New SIRT Guideline Recommendations: Driving Personalized Dosimetry with SIR-Spheres 90Y-resin microspheres. Invited. GEST Sirtex Symposium. Online Conference, US.
- 2021. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. Invited. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. Online Conference, US.
- 2020. SPECT/CT imaging for Sentinel Lymph Node (SLN) mapping, EGOC-ACRIN Fall Meeting. Invited. Online Conference, US.
- 2020. EANM/AAPM Symposium: Quantitative SPECT – An essential tool? The Limitations and Pitfalls of Quantitative SPECT. Invited. European Association of Nuclear Medicine, Online Annual Congress, US.
- 2020. Y90 Radioembolization Course: Radiation Physics and Y90, Society of Interventional Oncology. Invited. Y90 Radioembolization Course: Radiation Physics and Y90, Society of Interventional Oncology. Online Conference, US.
- 2020. Imaging and Dosimetry for 90Y Microsphere Therapies. Invited. 2020 Spring Clinical Meeting of the American Association for Physicists in Medicine, US.
- 2020. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course. Invited. Society of Interventional Radiology. San Francisco, CA, US.
- 2019. Innovation in Hybrid Imaging: SPECT/CT Quantitation. Invited. Annual Meeting of the Radiological Society of North America. Chicago, IL, US.
- 2019. The Importance of Dosimetry in Radionuclide Therapy, Brazilian Medical Physics Association (ABFM). Invited. Online Annual Meeting, US.
- 2019. Joint AAPM.SNMMI Symposium: Image-guided 90Y-radionuclide treatment planning, delivery and verification for hepatic cancers. Invited. Annual Meeting of American Association for Physicists in Medicine. San Antonio, TX, US.
- 2019. Image-guided 90Y-radionuclide treatment planning, delivery and verification. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Anaheim, CA, US.
- 2019. SIR Connect Live – Y90 Radioembolization. Invited. Annual meeting of the Society of Interventional Radiology. Austin, TX, US.
- 2019. Theoretical Aspects of SPECT/CT, IAEA Regional Training Course on Targeted Radionuclide Therapy. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2019. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course. Invited. Society of Interventional Radiology. San Francisco, CA, US.
- 2019. Treatment Planning, IAEA Regional Training Course on Targeted Radionuclide Therapy. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2018. The 90Y-microsphere Radioembolization Program at MD Anderson Cancer Center. Invited. The Mayo Clinic at Jacksonville. Jacksonville, FL, US.
- 2018. Accreditation for NM Systems, IAEA-ANL Interregional Course on Targeted Radionuclide Therapies. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2018. Y-90 Therapy, IAEA-ANL Strategy Workshop on Strengthening Nuclear Medicine in Africa with Incorporated Training on Establishing Nuclear Medicine Quality Assurance Management System. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2018. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. Invited. Physics Theory: Review of Prerequisite Work, Y90 The Complete Course, Society of Interventional Radiology. La Jolla, CA, US.
- 2018. Dosimetry, IAEA-ANL Strategy Workshop on Strengthening Nuclear Medicine in Africa with Incorporated Training on Establishing Nuclear Medicine Quality Assurance Management System. Invited. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2017. SAM Imaging Education Course: Yttrium-90 Microsphere Therapy: Emerging Trends and Future Directions. Invited. American Association for Physicists in Medicine. Denver, CO, US.
- 2017. Quantitation for SPECT/CT, Categorical Course SPECT/CT: Clinical Applications and Quantification. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Denver, CO, US.
- 2017. Recent Advances in 90Y-microsphere Selective Internal Radiation Therapy (SIRT): Dosimetry and Response Assessment. Invited. Banner MD Anderson Cancer Center. Phoenix, AZ, US.
- 2017. Dosimetry and Response Assessment following 90Y-Microsphere Therapy. Invited. Arizona Chapter of the American Association for Physicists in Medicine. Phoenix, AZ, US.
- 2016. Planar and SPECT ACR Accreditation. Invited. IAEA Nuclear Medicine Workshop. Houston, TX, US.
- 2016. Recent Advances in Liver-Directed Y90 Microsphere Selective Internal Radiation Therapy (90Y-SIRT). Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. San Diego, CA, US.
- 2016. MBI Physicist Perspective: Advances in Instrumentation and Minimizing Patient Radiation Exposure. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. San Diego, CA, US.
- 2016. SPECT/CT: Basics, Quality Assurance, and Clinical Applications. Invited. 2016 Spring Clinical Meeting of the American Association for Physicists in Medicine. Salt Lake City, UT, US.
- 2016. Molecular Breast Imaging: History and Recent Developments. Invited. 2016 Spring Clinical Meeting of the American Association for Physicists in Medicine. Salt Lake City, UT, US.
- 2015. Molecular Breast Imaging: An Adjunct Diagnostic Modality for Breast Cancer Evaluation. Conference. 102nd Annual Radiological Society of North America 2015 Meeting. Chicago, IL, US.
- 2015. Recent Advances in SPECT/CT and PET/CT for Oncology. Invited. American Association for Physicists in Medicine. Anaheim, CA, US.
- 2015. Current Trends in Yttrium-90 Microsphere Therapy Planning and Dosimetry. Invited. American Association for Physicists in Medicine. Anaheim, CA, US.
- 2015. Quantitative SPECT/CT for Targeted Radionuclide Dosimetry. Invited. Delaware Valley Chapter of the American Association for Physicists in Medicine. Philadelphia, PA, US.
- 2015. Molecular Breast Imaging. Invited. Southwest Chapter of the American Association for Physicists in Medicine. Galveston, TX, US.
- 2014. Performance Evaluation of Material Decomposition with Rapid kVp-switching Dual-energy CT and Implications for Assessing Bone Mineral Density. Conference. 101st Annual Radiological Society of North America 2014 Meeting. Chicago, IL, US.
- 2014. SAM Imaging Education Course: Basic Principles of PET/CT, Calibration Methods and Contrast Recovery Across Multiple Cameras. Invited. 56th Annual Meeting of the American Association for Physicists in Medicine. Austin, TX, US.
- 2014. 90Y-microsphere Therapy Planning and Dose Calculations. Invited. Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. St. Louis, MO, US.
- 2014. Radiobiological Modeling and Voxel-based Dosimetry for Liver-directed Yttrium-90 Microsphere Therapies. Invited. Southwest Chapter of the American Association for Physicists in Medicine. San Antonio, TX, US.
- 2012. SAM Imaging Symposium: Radionuclide Imaging: Yttrium-90 Microsphere Therapy Planning and Dose Calculations. Invited. 54th Annual Meeting of the American Association for Physicists in Medicine. Charlotte, NC, US.
- 2010. SAM Imaging Symposium: Radionuclide Imaging: SPECT/CT: Basics, Quality Assurance, and Clinical Applications. Invited. 52nd Annual Meeting of the American Association for Physicists in Medicine. Philadelphia, PA, US.
- 2010. Molecular Imaging-Guided Therapy: Nuclear Medicine Imaging in Yttrium-90 Microsphere Radioembolization Therapies. Invited. 57th Annual Meeting of the Society of Nuclear Medicine. Salt Lake City, UT, US.
- 2009. SAM Imaging Symposium: Radionuclide Imaging: SPECT/CT: Basics, Technology Updates, Quality Assurance, and Applications. Invited. 51st Annual Meeting of the American Association for Physicists in Medicine. Anaheim, CA, US.
- 2008. SNMTS Categorical Course, PET: Current and Upcoming Technology: Radiation Safety. Invited. 55th Annual Meeting of the Society of Nuclear Medicine. New Orleans, LA, US.
- 2008. SNMTS Continuing Education, Radiation Safety: Does Your Environment Get The Green Light?. Invited. 55th Annual Meeting of the Society of Nuclear Medicine. New Orleans, LA, US.
- 2008. Professional Symposium: ABR Examination Update. Invited. 25th Annual Meeting of the American College of Medical Physics. Seattle, WA, US.
- 2008. Molecular and Multimodality Imaging /Therapy: SPECT-CT: Developments in Clinical Applications. Invited. Southwest Chapter of the American Association for Physicists in Medicine. Austin, TX, US.
- 2007. Dual energy digital mammography for imaging calcifications. Invited. University of Washington. Seattle, WA, US.
- 2007. Dual energy digital mammography for imaging calcifications. Invited. Mayo Clinic. Rochester, MN, US.
- 2006. Dual energy digital mammography. Invited. Louisiana State University. Baton Rouge, LA, US.
- 2006. Developing IDL applications in Siemens e.soft environment. Conference. IDL User Group. San Diego, CA, US.
International Presentations
- 2024. Advancements in Yttrium-90 Therapeutic Techniques and Dosimetric Innovations. Invited. Picaso Hospital Taylor's University. Kuala Lumpur, MY.
- 2024. The Role of Medical Physicist in Clinical Practice and Research. Invited. University of Malaya Medical Center. Kuala Lumpur, MY.
- 2024. Personalized and Precise Dosimetry for SIR-Spheres Y90-resin Microspheres Resin dosimetry. Invited. Tata Memorial Hospital. Mumbai, IN.
- 2022. Post-treatment Imaging. Invited. Radioembolization Workshop. Utrecht, NL.
- 2022. Dosimetry and Yttrium-Resin Microspheres. Invited. Radioembolization Workshop. Utrecht, NL.
- 2019. AAPM/WMIS Joint Session: Image-Guided Cancer Therapy, The interface of molecular imaging and technology. Image-guided 90Y radio-microsphere treatment planning and delivery. Invited. World Molecular Imaging Congress. Montreal, US.
- 2019. NET Symposium: Advances in treatment of neuro-endocrine tumor liver metastases, Radioembolization Dosimetry. Invited. University Medical Center. Utrecht, NL.
- 2018. Radioembolization Dosimetry – The road towards individualized treatment planning. Invited. Dutch Nuclear Medicine Society. Kaatsheuvel, NL.
- 2018. Advancing SIRT Technology for the Future: The Importance of Accurate Dosimetry from Start to Finish, Annual meeting of the European Association of Nuclear Medicine. Invited. Advancing SIRT Technology for the Future: The Importance of Accurate Dosimetry from Start to Finish, Annual meeting of the European Association of Nuclear Medicine. Dusseldorf, DE.
- 2016. Radioembolization Dosimetry. Invited. Symposium on Advances in Nuclear Therapy, University Medical Center. Utrecht, NL.
- 2016. Advances in Dosimetry and Response Assessment. Invited. Holmium, the Next Generation Microspheres for Radioembolization, University Medical Hospital. Utrecht, NL.
- 2011. SAM Imaging Symposium: Radionuclide Imaging: Yttrium-90 Microsphere Therapy Planning and Dose Calculations. Invited. 53rd Annual Meeting of the American Association for Physicists in Medicine. Vancouver, CA.
- 2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Basics of SPECT/CT System. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.
- 2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Introduction to SPECT/CT Quality Control. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.
- 2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Image Reconstruction and Attenuation Correction. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.
- 2009. SPECT/CT Course and Workshop: Fundamentals, Instrumentation, and Techniques: Quantitative Imaging in SPECT/CT. Invited. King Faisal Specialist Hospital and Research Center. Riyadh, SA.
Grant & Contract Support
| Date: | 2024 - 2025 |
| Title: | Lung Shunt and Dose Verification Following 90Y-Microsphere Radioembolization Treatments |
| Funding Source: | American Association of Physicists in Medicine |
| Role: | Co-I |
| Date: | 2023 - 2024 |
| Title: | Kappadath: AAPM Travel Award |
| Funding Source: | American Association of Physicists in Medicine |
| Role: | Investigator |
| Date: | 2023 - 2024 |
| Title: | TriNav Infusion System for the Evaluation of Fidelity between 99m Tc-MAA and Y90-Microspheres Hepatic Distribution for Dosimetry Treatment Planning |
| Funding Source: | TriSalus Life Sciences |
| Role: | Co-PI |
| ID: | NCT05743842 |
| Date: | 2023 - Present |
| Title: | Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients with Colorectal Liver Metastases |
| Funding Source: | Sirtex Medical, Inc |
| Role: | Co-I |
| Date: | 2022 - 2023 |
| Title: | Evaluation of novel MBI tumor uptake metric, SUVb, for predicting tumor response in breast cancer patients |
| Funding Source: | MDACC-QIAC Grant |
| Role: | Co-PI |
| Date: | 2022 - 2027 |
| Title: | Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology |
| Funding Source: | NIH/NCI |
| Role: | Co-Mentor |
| ID: | 5T32CA196561-08 |
| Date: | 2021 - 2023 |
| Title: | Novel PET Imaging to Guide Yttrium-90 Radioembolization Therapy in Hepatocellular Carcinoma |
| Funding Source: | MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma |
| Role: | Co-I |
| ID: | P50CA217674 |
| Date: | 2021 - 2026 |
| Title: | InHANCE: Imaging Innovation for Head And Neck Cancer Evaluation & Treatment Delivery |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1P01CA254866-01A1 |
| Date: | 2021 - 2025 |
| Title: | A prospective, multicenter, open-label single arm study evaluating the safety and efficacy of selective internal radiation therapy (SIRT) using SIR-Spheres® Y-90 resin microspheres on duration of response (DoR) and objective response rate (ORR) in unresectable hepatocellular carcinoma (HCC) patients |
| Funding Source: | Sirtex Medical, Inc |
| Role: | PI |
| ID: | NCT04736121 |
| Date: | 2020 - 2021 |
| Title: | WS#29 Establish the minimum detectable PET activity concentrations when imaging F-18 and Ga-68 labeled prostate cancer radiotracers with the Sigma PET/MR |
| Funding Source: | GE Healthcare |
| Role: | PI |
| ID: | 00058508 |
| Date: | 2020 - 2022 |
| Title: | Enhanced selective internal radiation therapy based on remote control of individual radiation sources |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1 R21 CA241837-01A1 |
| Date: | 2020 - 2023 |
| Title: | Evaluation of the distribution of radiopaque non-radioactive (EYE90) 90Y-radioembolic microsphere in liver and kidneys in a swine model |
| Funding Source: | ABK Biomedical |
| Role: | PI |
| ID: | #57397 |
| Date: | 2020 - 2027 |
| Title: | A Phase 1 open-label, first-in-human, multi-center study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity of thorium-227 labeled antibodychelator conjugate BAY 2701439, in participants with advanced HER2-expressing tumors |
| Funding Source: | BAYER HEALTHCARE PHARMACEUTICALS |
| Role: | Co-I |
| ID: | 2019-0771 |
| Date: | 2019 - 2026 |
| Title: | An Open-Label, First-In-Human, Multi-Center Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Anti-Tumor Activity of A Thorium-227 Labeled Antibody-Chelator Conjugate, BAY 2287411 Injection, In Patients with Solid Tumors Known To Express Mesothelin |
| Funding Source: | BAYER HEALTHCARE PHARMACEUTICALS |
| Role: | Co-I |
| ID: | 2019-0363 |
| Date: | 2019 - 2024 |
| Title: | Radioembolization for HCC Patients with Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D) |
| Funding Source: | Boston Scientific BTG |
| Role: | Co-PI |
| ID: | NCT03896646 |
| Date: | 2017 - 2020 |
| Title: | NCT03295006 - A TheraSphere Advanced Dosimetry Retrospective Global Evaluation in Hepatocellular Carcinoma Treatment (TARGET) |
| Funding Source: | BTG International Inc |
| Role: | PI |
| Date: | 2016 - 2019 |
| Title: | NCT03188328- A dose escalation study to evaluate safety, tolerability, pharmacokinetics, dosimetry, maximum tolerated dose and preliminary efficacy of intra-lesionally injected AvidinOX, followed by systemic IV administration of escalating doses of [177Lu]DOTA-biotin in patients with solid tumors or lymphomas with injectable neoplastic lesions |
| Funding Source: | Sigma Tau |
| Role: | Co-I |
| ID: | 2016-0262 |
| Date: | 2016 - 2019 |
| Title: | NCT03028311 - Feasibility of Single Session In-Room Yttrium-90 Radioembolization Diagnostic Angiography and Treatment |
| Funding Source: | SIRTEX Medical Limited |
| Role: | Co-PI |
| ID: | 13015485-V101 |
| Date: | 2016 - 2020 |
| Title: | In Vivo Molecular Breast Imaging with Tc‐99m Sestamibi for the Prediction of Multidrug Resistance in Triple Negative Breast Cancers |
| Funding Source: | MDACC/GE Healthcare CABI MI2 |
| Role: | Co-I |
| Date: | 2015 - 2019 |
| Title: | Quantitative 99mTc-Sestamibi Molecular Breast Imaging (MBI) using GE Discovery NM750b |
| Funding Source: | GE-CABI, General Electric |
| Role: | PI |
| Date: | 2014 - 2019 |
| Title: | Quantitative 90Y PET/CT: Quest Site Assessment Study |
| Funding Source: | SIRTEX Medical Limited |
| Role: | PI |
| Date: | 2013 - 2015 |
| Title: | Radiation dose reduction by combining contrast-enhanced diagnostic CT examinations with 99mTc-MDP SPECT examinations using dual-modality SPECT/CT |
| Funding Source: | MDACC Institutional Research Grant |
| Role: | PI |
| ID: | FRED#34737 |
| Date: | 2013 - 2014 |
| Title: | Develop methodology to separately compute the trabecular and cortical bone-mineral density using the GE Discovery CT 750HD scanner with GSI |
| Funding Source: | General Electric |
| Role: | PI |
| ID: | GE-CABI |
| Date: | 2012 - 2016 |
| Title: | A novel dose calculation method for targeted radionuclide therapy |
| Funding Source: | Christiana Care Health Services/NIH |
| Role: | PI |
| ID: | R01-CA13896-02, (Sub-award No. 601889) |
| Date: | 2012 - 2013 |
| Title: | Optimization of the Yttrium-90 bremsstrahlung SPECT/CT for SymbiaT SPECT/CT scanners |
| Funding Source: | Siemens Medical Solutions |
| Role: | PI |
| Date: | 2012 - 2017 |
| Title: | Multi-modal reconstruction and quantitative SPECT imaging |
| Funding Source: | Siemens Medical Solutions |
| Role: | Co-I |
| ID: | LS2012-00036240LG-03 |
| Date: | 2011 - 2016 |
| Title: | Reporter-based stem cell imaging and therapy |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | 1-R01-CA138386 |
| Date: | 2009 - 2012 |
| Title: | Quantitative 90Y bremsstrahlung SPECT/CT to estimate tumor radiation dose in vivo |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01-CA149133 |
| Date: | 2002 - 2006 |
| Title: | aSi/CsI FP digital chest imaging with scatter rejection and exposure equalization |
| Funding Source: | NIH/NIBIB |
| Role: | Co-I |
| ID: | EB000117 |
| Date: | 2000 - 2004 |
| Title: | Dual-Energy Digital Mammography |
| Funding Source: | United States Army Breast Cancer Research Program |
| Role: | Co-I |
| ID: | DAMO17-00-1-0316 |
Patient Reviews
CV information above last modified May 22, 2025