Scott E. Evans, MD, FCCP, ATSF
Department of Pulmonary Medicine, Division of Internal Medicine
In the News
Present Title & Affiliation
Primary Appointment
Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Department Chair ad interim, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Rebecca Meyer Brown and Joseph Mellinger Brown Chair in Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston
Dual/Joint/Adjunct Appointment
Adjunct Professor, School of Medicine, Tecnologico de Monterrey, Monterrey
Regular Faculty Member, Division of Program in Immunology, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Regular Faculty Member, Division of Program in Biochemistry and Cell Biology, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Research Interests
The entirety of my professional effort, both laboratory and clinical, is focused on the mechanisms that prevent humans from universally succumbing to the microbial pathogens they inhale or aspirate every day. In particular, I am interested in how non-HIV immunocompromised patients respond to the presence of respiratory pathogens. My goal is to exploit these native mechanisms to provide more comprehensive protection during episodes of peak vulnerability, such as when cancer patients receive chemotherapy. My laboratory is currently engaged full-time in mechanistic studies intended to unravel the means by which our recently described phenomenon of inducible resistance protects against pneumonia. Our available data indicate that this protective response occurs via antimicrobial product generation from treated respiratory epithelial cells, rather than through the typical leukocyte effectors of the innate immune system. My long term objective is to develop a research program focused on discovery and manipulation of epithelium-derived antimicrobial mediators that can ultimately be translated for clinical benefit.
Education & Training
Degree-Granting Education
| 1999 | University of Texas Medical School, San Antonio, TX, USA, MD, Medicine |
| 1994 | University of Texas, Austin, TX, USA, BA, Plan II Honors Program |
Postgraduate Training
| 2004-2005 | Administrative (Chief) Fellow, Pulmonary Medicine, Mayo Graduate School of Medicine, Rochester, MN |
| 2002-2005 | Clinical Fellowship, Pulmonary & Critical Care Medicine, Mayo Graduate School of Medicine, Rochester, MN |
| 2002-2004 | Clinician-Investigator Research Training Program, Mayo Graduate School of Medicine, Rochester, MN |
| 1999-2002 | Clinical Internship and Residency, Internal Medicine, Mayo Graduate School of Medicine, Rochester, MN |
Experience & Service
Academic Appointments
Associate Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2019
Graduate Faculty, Texas A&M Health Science Center School of Graduate Studies, College Station, TX, 2010 - 2015
Adjunct Faculty, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, 2006 - 2015
Assistant Professor, Department of Critical Care Medicine, Division of Anesthesiology, Critical Care Medicine and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005 - 2009
Assistant Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005 - 2013
Administrative Appointments/Responsibilities
Director of Basic and Translational Research, Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2021
Other Appointments/Responsibilities
Faculty, MD Anderson Medical Mycology Research Center, Houston, TX, 2018 - Present
Institutional Committee Activities
Member, The University of Texas MD Anderson Cancer Center, CCSG Research Animal Support Facility Program Income Advisory Committee, 2020 - Present
Member, MD Anderson UTHealth Graduate School in Biomedical Sciences, Biochemistry and Cell Biology Program Examination Committee, 2020 - Present
Member, The University of Texas MD Anderson Cancer Center, Promotion and Tenure Committee, 2019 - 2021
Member, The University of Texas MD Anderson Cancer Center, Multidisciplinary Research Program Committee, 2018 - Present
Member, MD Anderson UTHealth Graduate School in Biomedical Sciences, Program in Immunology Admissions Subcommittee, 2018 - Present
Member, MD Anderson UTHealth Graduate School in Biomedical Sciences, Program in Immunology Steering Committee, 2016 - 2018
Member, The University of Texas MD Anderson Cancer Center, Physician-Scientist Program Advisory Committee, 2014 - Present
Member, The University of Texas MD Anderson Cancer Center, Physician-Scientist Task Force, 2014 - 2016
Member, The University of Texas MD Anderson Cancer Center, Institutional Infection Control Committee, 2008 - Present
Member, The University of Texas MD Anderson Cancer Center, Pneumonia Working Group, 2006 - Present
Honors & Awards
| 2022 | Elected Member, American Society for Clinical Investigation |
| 2019 | Cyrus Scholar Award, Cyrus Family Foundation |
| 2019 | Fellow, American Thoracic Society |
| 2016 | Pulmonary Infection and Tuberculosis Assembly Mid-Career Peer Recognition Award, American Thoracic Society |
| 2014 | Presidential Recognition for Faculty Excellence, The University of Texas MD Anderson Cancer Center |
| 2014 | Cyrus Scholar Award, Cyrus Family Foundation |
| 2013 | Distinguished Paper Award, The University of Texas MD Anderson Division of Internal Medicine |
| 2013 | NIH Director's New Innovator Award, NIH Office of the Director |
| 2010 | Cyrus Scholar Award, Cyrus Family Foundation |
| 2008 | Physician-Scientist Award, The University of Texas MD Anderson Cancer Center |
| 2008 | Best Abstract, The University of Texas MD Anderson Cancer Center Division of Internal Medicine Research Retreat |
| 2008 | Charles E. Culpeper Scholarship in Medical Science, Partnership for Cures/Culpeper Foundation |
| 2008 | Fellow, American College of Chest Physicians |
| 2007 | Best Poster: Basic Science-Diagnostics, The University of Texas MD Anderson Cancer Center Division of Internal Medicine Retreat |
| 2007 | Best Poster: Clinical-Prevention, The University of Texas MD Anderson Cancer Center Division of Internal Medicine Retreat |
| 2007 | Career Development Award, University of Texas Centers for Clinical and Translational Science |
| 2007 | NIH Loan Repayment Program Award, Clinical Research |
| 2005 | Travel Grant, American Thoracic Society |
| 2004 | Burgher Family Endowed Pulmonary Fellowship Award |
| 2003 | Young Investigator Award, ACCP Chest Foundation |
| 2003 | Second Place, National CHEST Challenge, American College of Chest Physicians |
| 2003 | Trainee Travel Award, Experimental Biology, Federation of American Societies for Experimental Biology |
| 2003 | Scholar Award, GlaxoSmithKline |
| 2003 | Trainee Travel Award, Clinical Research, American Federation for Medical Research |
| 2002 | Trainee Travel Award, Clinical Research, American Federation for Medical Research |
| 2002 | Travel Award, Combined Annual Meeting, Central Society for Clinical Research |
| 2002 | Young Investigator Endowed Fellowship, Hartz Foundation |
| 2002 | Graduation Rank #1, Mayo Internal Medicine Residency Program |
| 2002 | Outstanding Achievement Award, Mayo Internal Medicine Residency Program |
| 2001 | Travel Award, 4th Annual International LAM Research Conference, NHLBI/LAM Foundation |
| 1999 | Holt Leadership Award, University of Texas Medical School |
| 1998 | Alpha Omega Alpha Honor Medical Society |
| 1997 | National Achievement Award, American Medical Association/GlaxoWellcome |
| 1996 | Certificate of Excellence for Outstanding Service, Texas State Senate |
| 1993 | Order of Omega Academic Honor Society |
| 1992 | Theta Award for Academic Excellence, University of Texas at Austin |
| 1990 | Terry Foundation Scholar |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Johnson AN, Dickinson J, Nelson A, Gaurav R, Kudrna K, Evans SE, Janike K, Wyatt TA, Poole JA. Effect of epithelial-specific MyD88 signaling pathway on airway inflammatory response to organic dust exposure. J Immunotoxicol 20(1):2148782, 2023. PMID: 36538286.
- Goldblatt DL, Valverde Ha G, Wali S, Kulkarni VV, Longmire MK, Jaramillo AM, Chittuluru RP, Fouts A, Purresh TF, Martinez-Moczygemba M, Lei JT, Huston DP, Tuvim MJ, Dickey BF, Evans SE. Epithelial immunomodulation by aerosolized Toll-like aeceptor agonists attenuates allergic responsiveness in mice. Eur J Pharmacol, 2022.
- Shivshankar P, Karmouty-Quintana H, Mills T, Doursout MF, Wang Y, Czopik AK, Evans SE, Eltzschig HK, Yuan X. SARS-CoV-2 Infection: Host Response, Immunity, and Therapeutic Targets. Inflammation 45(4):1430-1449, 2022. e-Pub 2022. PMID: 35320469.
- Pantaleón García J, Dickson RP, Evans SE. Minimizing caging effects in murine lung microbiome studies. Am J Physiol Lung Cell Mol Physiol 323(2):L219-L220, 2022. PMID: 35944140.
- Losier A, Harding WC, Dela Cruz CS, Evans S, Ruminjo JK, Thomson C. Summary for Clinicians: Clinical Practice Guideline for the Use of Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. Ann Am Thorac Soc 19(7):1081-1083, 2022. e-Pub 2022. PMID: 35353672.
- Pantaleón García J, Kulkarni VV, Reese TC, Wali S, Wase SJ, Zhang J, Singh R, Caetano MS, Kadara H, Moghaddam SJ, Johnson FM, Wang J, Wang Y, Evans SE. OBIF: an Omics-based interaction framework to reveal molecular drivers of synergy. NAR Genom Bioinform 4(2):lqac028, 2022. e-Pub 2022. PMID: 35387383.
- Yuan X, Mills T, Doursout MF, Evans SE, Vidal Melo MF, Eltzschig HK. Alternative adenosine Receptor activation: The netrin-Adora2b link. Front Pharmacol 13:944994, 2022. e-Pub 2022. PMID: 35910389.
- Wang Y, Abe JI, Chau KM, Wang Y, Vu HT, Reddy Velatooru L, Gulraiz F, Imanishi M, Samanthapudi VSK, Nguyen MTH, Ko KA, Lee LL, Thomas TN, Olmsted-Davis EA, Kotla S, Fujiwara K, Cooke JP, Zhao D, Evans SE, Le NT. MAGI1 inhibits interferon signaling to promote influenza A infection. Front Cardiovasc Med 9:791143, 2022. e-Pub 2022. PMID: 36082118.
- Goldblatt DL, Valverde Ha G, Wali S, Kulkarni VV, Longmire MK, Jaramillo AM, Chittuluru RP, Fouts A, Martinez-Moczygemba M, Lei JT, Huston DP, Tuvim MJ, Dickey BF, Evans SE. Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice. Front Pharmacol 13:833380, 2022. e-Pub 2022. PMID: 36105216.
- Pantaleón García J, Hinkle KJ, Falkowski NR, Evans SE, Dickson RP. Selective Modulation of the Pulmonary Innate Immune Response Does not Change Lung Microbiota in Healthy Mice. Am J Respir Crit Care Med 204(6):734-736, 2021. e-Pub 2021. PMID: 34153197.
- Smith AM, Harper N, Meunier JA, Branum AP, Jimenez F, Pandranki L, Carrillo A, Dela Cruz CS, Restrepo MI, Maselli DJ, Rather CG, Heisser AH, Ramirez DA, He W, Clark RA, Andrews CP, Evans SE, Pugh JA, Zhang N, Lee GC, Moreira AG, Segal LN, Ramirez RM, Jacobs RL, Manoharan MS, Okulicz JF, Ahuja SK. Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases. J Allergy Clin Immunol 148(2):533-549, 2021. e-Pub 2021. PMID: 33493557.
- Czopik A, Yuan X, Evans SE, Eltzschig HK. Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation. Anesthesiology 135(1):15-17, 2021. e-Pub 2021. PMID: 34046661.
- Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 18(7):1087-1097, 2021. PMID: 34242148.
- Epelbaum O, Carmona EM, Evans SE, Hage CA, Jarrett B, Knox KS, Limper AH, Pennington KM. Antifungal Prophylaxis for Adult Recipients of Veno-Venous Extracorporeal Membrane Oxygenation: A Cautionary Stance During the COVID-19 Pandemic. ASAIO J 67(6):611-613, 2021. e-Pub 2021. PMID: 33769344.
- Cilloniz C, Simonds A, Hansen K, Alouch J, Zar H, Nakanishi Y, Levine S, Cohen M, Dela Cruz C, Evans SE, Sanguinetti M, Vila J, Díez Manglano J, Ferrer R, Criado L, Polo García J, Correcher Z, Rodriguez-Hurtado D, Terrazas C, Muñoz-Almagro C, Garcia-Vidal C, Aoun Z, Amirav I. Pulse oximetry is an essential tool that saves lives: a call for standardisation. Eur Respir J 57(6), 2021. e-Pub 2021. PMID: 34088755.
- Evans SE, Jennerich AL, Azar MM, Cao B, Crothers K, Dickson RP, Herold S, Jain S, Madhavan A, Metersky ML, Myers LC, Oren E, Restrepo MI, Semret M, Sheshadri A, Wunderink RG, Dela Cruz CS. Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 203(9):1070-1087, 2021. PMID: 33929301.
- Wali S, Flores JR, Jaramillo AM, Goldblatt DL, Pantaleón García J, Tuvim MJ, Dickey BF, Evans SE. Immune Modulation to Improve Survival of Viral Pneumonia in Mice. Am J Respir Cell Mol Biol 63(6):758-766, 2020. e-Pub 2020. PMID: 32853024.
- Ramirez JA, Musher DM, Evans SE, Dela Cruz C, Crothers KA, Hage CA, Aliberti S, Anzueto A, Arancibia F, Arnold F, Azoulay E, Blasi F, Bordon J, Burdette S, Cao B, Cavallazzi R, Chalmers J, Charles P, Chastre J, Claessens YE, Dean N, Duval X, Fartoukh M, Feldman C, File T, Froes F, Furmanek S, Gnoni M, Lopardo G, Luna C, Maruyama T, Menendez R, Metersky M, Mildvan D, Mortensen E, Niederman MS, Pletz M, Rello J, Restrepo MI, Shindo Y, Torres A, Waterer G, Webb B, Welte T, Witzenrath M, Wunderink R. Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies. Chest 158(5):1896-1911, 2020. e-Pub 2020. PMID: 32561442.
- Evans SE, Tseng CK, Scott BL, Höök AM, Dickey BF. Inducible Epithelial Resistance Against Coronavirus Pneumonia in Mice. Am J Respir Cell Mol Biol 63(4):540-541, 2020. e-Pub 2020. PMID: 32706609.
- Dawood W, Evans SE, Grosu H. Mediastinal lymphadenitis due to Nocardia infection. J Bronchology Interv Pulmonol 27(3):e48-e51, 2020. PMID: 32569081.
- Pacha O, Sallman MA, Evans SE. COVID-19: a case for inhibiting IL-17?. Nat Rev Immunol 20(6):345-346, 2020. e-Pub 2020. PMID: 32358580.
- Goldblatt DL, Flores JR, Valverde Ha G, Jaramillo AM, Tkachman S, Kirkpatrick CT, Wali S, Hernandez B, Ost DE, Scott BL, Chen J, Evans SE, Tuvim MJ, Dickey BF. Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. Br J Pharmacol 177(10):2256-2273, 2020. e-Pub 2020. PMID: 31968123.
- Wunderink RG, Srinivasan A, Barie PS, Chastre J, Dela Cruz CS, Douglas IS, Ecklund M, Evans SE, Evans SR, Gerlach AT, Hicks LA, Howell M, Hutchinson ML, Hyzy RC, Kane-Gill SL, Lease ED, Metersky ML, Munro N, Niederman MS, Restrepo MI, Sessler CN, Simpson SQ, Swoboda SM, Guillamet CV, Waterer GW, Weiss CH. Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM. Ann Am Thorac Soc 17(5):531-540, 2020. PMID: 32356696.
- Covés-Datson EM, King SR, Legendre M, Gupta A, Chan SM, Gitlin E, Kulkarni VV, Pantaleón García J, Smee DF, Lipka E, Evans SE, Tarbet EB, Ono A, Markovitz DM. A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo. Proc Natl Acad Sci U S A 117(4):2122-2132, 2020. e-Pub 2020. PMID: 31932446.
- Kim ST, Sheshadri A, Shannon V, Kontoyiannis DP, Kantarjian H, Garcia-Manero G, Ravandi F, Im JS, Boddu P, Bashoura L, Balachandran DD, Evans SE, Faiz S, Ruiz Vazquez W, Divenko M, Mathur R, Tippen SP, Gumbs C, Neelapu SS, Naing A, Wang L, Diab A, Futreal A, Nurieva R, Daver N. Distinct immunophenotypes of T cells in bronchoalveolar lavage fluid from leukemia patients with immune checkpoint inhibitors-related pulmonary complications. Front Immunol 11:590494, 2020. e-Pub 2021. PMID: 33552049.
- Hage CA, Carmona EM, Evans SE, Limper AH, Ruminjo J, Thomson CC. Summary for Clinicians: Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. Ann Am Thorac Soc 16(12):1473-1477, 2019. PMID: 31526275.
- Vichaya EG, Gross PS, Estrada DJ, Cole SW, Grossberg AJ, Evans SE, Tuvim MJ, Dickey BF, Dantzer R. Lipocalin-2 is dispensable in inflammation-induced sickness and depression-like behavior. Psychopharmacology (Berl) 236(10):2975-2982, 2019. e-Pub 2019. PMID: 30806746.
- Haydour Q, Hage CA, Carmona EM, Epelbaum O, Evans SE, Gabe LM, Knox KS, Kolls JK, Wengenack NL, Prokop LJ, Limper AH, Murad MH. Diagnosis of Fungal Infections: A Systematic Review and Meta-Analysis Supporting ATS Clinical Practice Guideline. Ann Am Thorac Soc 16(9):1179-1188, 2019. e-Pub 2019. PMID: 31219341.
- Hage CA, Carmona EM, Epelbaum O, Evans SE, Gabe LM, Haydour Q, Knox KS, Kolls JK, Murad MH, Wengenack NL, Limper AH. Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 200(5):535-550, 2019. PMID: 31469325.
- Sheshadri A, Karimipour M, Vakil E, Bashoura L, Godoy M, Arain MH, Evans SE, Dickey BF, Ost DE, Chemaly RF, Faiz SA. Refinement of estimates of mortality risk using the Radiologic Severity Index in hematologic malignancy patients with respiratory syncytial virus infection. Transpl Infect Dis 21(4):e13105, 2019. e-Pub 2019. PMID: 31081570.
- Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT. MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight 4(7), 2019. e-Pub 2019. PMID: 30944250.
- Ware HH, Kulkarni VV, Wang Y, Pantaleón García J, Leiva Juarez M, Kirkpatrick CT, Wali S, Syed S, Kontoyiannis AD, Sikkema WKA, Tour JM, Evans SE. Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections. PLoS One 14(2):e0208216, 2019. e-Pub 2019. PMID: 30794556.
- Sheshadri A, Godoy M, Erasmus JJ, Gruschkus S, Hasan A, Evans SE, Barreda-Garcia J, Chemaly RF, Dickey B, Ost D. Progression of the Radiologic Severity Index is associated with increased mortality and healthcare resource utilisation in acute leukaemia patients with pneumonia. BMJ Open Respir Res 6(1):e000471, 2019. e-Pub 2019. PMID: 31921429.
- Caetano MS, Hassane M, Van HT, Bugarin E, Cumpian AM, McDowell CL, Cavazos CG, Zhang H, Deng S, Diao L, Wang J, Evans SE, Behrens C, Wistuba II, Fuqua SAW, Lin H, Stabile LP, Watowich SS, Kadara H, Moghaddam SJ. Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer. Nat Commun 9(1):4589, 2018. e-Pub 2018. PMID: 30389925.
- Fernández-Cruz A, Magira E, Heo ST, Evans S, Tarrand J, Kontoyiannis DP. Bronchoalveolar lavage fluid cytology in culture-documented invasive pulmonary aspergillosis in patients with hematologic diseases: analysis of 67 episodes. J Clin Microbiol 56(10), 2018. e-Pub 2018. PMID: 30021823.
- Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia: NHLBI Working Group Report. Am J Respir Crit Care Med 198(2):256-263, 2018. e-Pub 2018. PMID: 29546996.
- Khosravi N, Caetano MS, Cumpian AM, Unver N, De la Garza Ramos C, Noble O, Daliri S, Hernandez BJ, Gutierrez BA, Evans SE, Hanash S, Alekseev AM, Yang Y, Chang SH, Nurieva R, Kadara H, Chen J, Ostrin EJ, Moghaddam SJ. IL-22 promotes K-ras mutant lung cancer by induction of a pro-tumor immune response and protection of stemness properties. Cancer Immunol Res 6(7):788-797, 2018. e-Pub 2018. PMID: 29764837.
- Kirkpatrick CT, Wang Y, Leiva Juarez MM, Shivshankar P, Pantaleón García J, Plumer AK, Kulkarni VV, Ware HH, Gulraiz F, Chavez Cavasos MA, Martinez Zayes G, Wali S, Rice AP, Liu H, Tour JM, Sikkema WKA, Cruz Solbes AS, Youker KA, Tuvim MJ, Dickey BF, Evans SE. Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against viral infections. MBio 9(3), 2018. e-Pub 2018. PMID: 29764948.
- Leiva-Juárez MM, Kolls JK, Evans SE. Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense. Mucosal Immunol 11(1):21-34, 2018. e-Pub 2017. PMID: 28812547.
- Leiva-Juarez MM, Kirkpatrick CT, Gilbert BE, Scott B, Tuvim MJ, Dickey BF, Evans SE, Markesich D. Combined aerosolized Toll-like receptor ligands are an effective therapeutic agent against influenza pneumonia when co-administered with oseltamivir. Eur J Pharmacol 818:191-197, 2018. e-Pub 2017. PMID: 29066417.
- Sheshadri A, Shah DP, Godoy M, Erasmus JJ, Song J, Li L, Evans SE, Chemaly RF, Dickey BF, Ost DE. Progression of the radiologic severity index predicts mortality in patients with parainfluenza virus-associated lower respiratory infections. PLoS One 13(5):e0197418, 2018. e-Pub 2018. PMID: 29771962.
- Leiva-Juárez MM, Ware HH, Kulkarni VV, Zweidler-McKay PA, Tuvim MJ, Evans SE. Inducible epithelial resistance protects mice against leukemia-associated pneumonia. Blood 128(7):982-92, 2016. e-Pub 2016. PMID: 27317793.
- Faiz SA, Bashoura L, Kodali L, Hessel AC, Evans SE, Balachandran DD. Sleep disordered breathing as a delayed complication of iatrogenic vocal cord trauma. Sleep Med 22:1-3, 2016. e-Pub 2016. PMID: 27544828.
- Yang J, Hernandez BJ, Martinez Alanis D, Narvaez del Pilar O, Vila-Ellis L, Akiyama H, Evans SE, Ostrin EJ, Chen J. The development and plasticity of alveolar type 1 cells. Development 143(1):54-65, 2016. e-Pub 2015. PMID: 26586225.
- Gonzalez CE, Johnson TN, Evans S, Kidin LM, George S, Haq S, DeJesus AY, Walters R, Rolston K. Assessing compliance with established pneumonia core measures at a comprehensive cancer center. J Healthc Qual 37(4):232-44, 2015. e-Pub 2014. PMID: 24629128.
- Han XY, Ihegword A, Evans SE, Zhang J, Li L, Cao H, Tarrand JJ, El-Kweifi O. Microbiological and clinical studies of legionellosis in 33 patients with cancer. J Clin Microbiol 53(7):2180-7, 2015. e-Pub 2015. PMID: 25926494.
- Xia X, Mai J, Xu R, Perez JE, Guevara ML, Shen Q, Mu C, Tung HY, Corry DB, Evans SE, Liu X, Ferrari M, Zhang Z, Li XC, Wang RF, Shen H. Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response. Cell Rep 11(6):957-66, 2015. e-Pub 2015. PMID: 25937283.
- Gonzalez C, Johnson T, Rolston K, Merriman K, Warneke C, Evans S. Predicting pneumonia mortality using CURB-65, PSI, and patient characteristics in patients presenting to the emergency department of a comprehensive cancer center. Cancer Med 3(4):962-70, 2014. e-Pub 2014. PMID: 24802800.
- Cleaver JO, You D, Michaud DR, Pruneda FA, Juarez MM, Zhang J, Weill PM, Adachi R, Gong L, Moghaddam SJ, Poynter ME, Tuvim MJ, Evans SE. Lung epithelial cells are essential effectors of inducible resistance to pneumonia. Mucosal Immunol 7(1):78-88, 2014. e-Pub 2013. PMID: 23632328.
- Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature 505(7483):412-6, 2014. e-Pub 2013. PMID: 24317696.
- Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF. Safety, tolerability, and biomarkers of the treatment of mice with aerosolized toll-like receptor ligands. Front Pharmacol 5:8, 2014. e-Pub 2014. PMID: 24567720.
- Garcia JB, Lei X, Wierda W, Cortes JE, Dickey BF, Evans SE, Ost DE. Pneumonia during remission induction chemotherapy in patients with acute leukemia. Ann Am Thorac Soc 10(5):432-40, 2013. e-Pub 2013. PMID: 23987587.
- Tuvim MJ, Clement CG, Huang ES, Cote GJ, Evans SE, Lei X, Deftos LJ, Gagel RF, Dickey BF. Deletion of the gene encoding calcitonin and CGRPα does not affect the outcome of severe infection in mice. Am J Respir Cell Mol Biol 49(1):151-5, 2013. e-Pub 2013. PMID: 23526213.
- Drake MG, Evans SE, Dickey BF, Fryer AD, Jacoby DB. TLR2/6 and TLR9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs. Am J Respir Cell Mol Biol 48(6):790-6, 2013. e-Pub 2013. PMID: 23449736.
- Evans SE, Kottom TJ, Pagano RE, Limper AH. Primary alveolar epithelial cell surface membrane microdomain function is required for Pneumocystis β-glucan-induced inflammatory responses. Innate Immun 18(5):709-16, 2012. e-Pub 2012. PMID: 22334619.
- Tuvim MJ, Gilbert BE, Dickey BF, Evans SE. Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia (***Top 10% most cited papers for this journal***). PLoS One 7(1):e30596, 2012. e-Pub 2012. PMID: 22299046.
- Sampsonas F, Kontoyiannis DP, Dickey BF, Evans SE. Performance of a standardized bronchoalveolar lavage protocol in a comprehensive cancer center: A prospective 2-year study. Cancer 117(15):3424-33, 2011. e-Pub 2011. PMID: 21246537.
- Evans SE, Tuvim MJ, Fox CJ, Sachdev N, Gibiansky L, Dickey BF. Inhaled innate immune ligands to prevent pneumonia. Br J Pharmacol 163(1):195-206, 2011. e-Pub 2011. PMID: 21250981.
- Duggan JM, You D, Cleaver JO, Larson DT, Garza RJ, Guzmán Pruneda FA, Tuvim MJ, Zhang J, Dickey BF, Evans SE. Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. J Immunol 186(10):5916-26, 2011. e-Pub 2011. PMID: 21482737.
- Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ. Interleukin 6 but not T helper 2 cytokines promotes lung carcinogenesis. Cancer Prev Res (Phila) 4(1):51-64, 2011. e-Pub 2010. PMID: 21098042.
- Evans SE, Scott BL, Clement CG, Larson DT, Kontoyiannis D, Lewis RE, Lasala PR, Pawlik J, Peterson JW, Chopra AK, Klimpel G, Bowden G, Höök M, Xu Y, Tuvim MJ, Dickey BF. Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol 42(1):40-50, 2010. e-Pub 2009. PMID: 19329554.
- Tuvim MJ, Evans SE (Co-First Author), Clement CG, Dickey BF, Gilbert BE. Augmented lung inflammation protects against influenza A pneumonia. PLoS One 4(1):e4176, 2009. e-Pub 2009. PMID: 19137067.
- Clement CG, Tuvim MJ, Evans CM, Tuvin DM, Dickey BF, Evans SE. Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice. Respir Res 10(10):70, 2009. PMID: 19635139.
- Clement CG, Evans SE (Co-First Author), Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med 177(12):1322-30, 2008. e-Pub 2008. PMID: 18388354.
- Evans SE, Hahn PY, McCann F, Kottom TJ, Pavlovic' ZV, Limper AH. (Cover Article) Pneumocystis cell wall β-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-ĸB-dependent mechanisms. Am J Respir Cell Mol Biol 32(6):490-7, 2005. e-Pub 2005. PMID: 15746433.
- Gilman G, Evans SE, Hansen WH, Barnes ME, Klarich KW. Evaluation of right pulmonary artery obstruction by echocardiography in a 32-year-old woman with suggested histoplasmosis. J Am Soc Echocardiogr 18(5):490-1, 2005. PMID: 15891762.
- Evans SE, Colby TV, Ryu JH, Limper AH. Transforming growth factor-β1 and extracellular matrix-associated fibronectin expression in pulmonary lymphangioleiomyomatosis. Chest 125(3):1063-70, 2004. PMID: 15006970.
- Limper AH, Lebron F, Evans SE, Hahn RY. Pneumocystis carinii: cell wall β-glucan-mediated pulmonary inflammation. J Eukaryot Microbiol 50 Suppl:646, 2003. PMID: 14736200.
- Hahn PY, Evans SE (Co-First Author), Kottom TJ, Standing JE, Pagano RE, Limper AH. Pneumocystis carinii cell wall β-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism. J Biol Chem 278(3):2043-50, 2003. PMID: 12419803.
- Evans SE, Leventakos K, Ben-Ami R, You D, Thakkar SG, Lewis RE, Kontoyiannis DP. Toll-deficient Drosophila are resistant to infection by Pneumocystis spp.: additional evidence of specificity to mammalian hosts. Virulence 1(6). e-Pub 2010. PMID: 21178507.
- Evans SE, Tuvim MJ, Zhang J, Larson DT, Garcia CD, Martinez Pro S, Coombes KR, Dickey BF. Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia. Respir Res 11(1):101. e-Pub 2010. PMID: 20653947.
- Wurster S, García JP, Albert ND, Jiang Y, Bhoda K, Kulkarni VV, Wang Y, Walsh TJ, Evans S, Kontoyiannis DP. Development of a corticosteroid-immunosuppressed mouse model to study the pathogenesis and therapy of influenza-associated pulmonary aspergillosis. J Infect Dis. e-Pub 2023. PMID: 36611269.
- Wang Y, Velatooru LR, Vu HT, Gulraiz F, Wang Y, Thomas TN, Masaki I, Kolta S, le NT, Evans SE, Abe J. Influenza A virus infection increases MAGI1 expression in endothelial cells and itsdepletion inhibits virus replication through increased expression of MX1. Frontiers in Cardiology. e-Pub 2022.
Invited Articles
- Young AY, Leiva Juarez MM, Evans SE. Fungal pneumonia in patients with hematologic malignancy and hematopoietic stem cell transplantation. Clin Chest Med 38(3):479-491, 2017. e-Pub 2017. PMID: 28797490.
- Wong JL, Evans SE. Bacterial pneumonia in patients with cancer: novel risk factors and management. Clin Chest Med 38(2):263-277, 2017. e-Pub 2017. PMID: 28477638.
- Vakil E, Evans SE. Viral pneumonia in patients with hematologic malignancy or hematopoietic stem cell transplantation. Clin Chest Med 38(1):97-111, 2017. e-Pub 2016. PMID: 28159165.
- Evans SE, Ost DE. Pneumonia in the neutropenic cancer patient. Curr Opin Pulm Med 21(3):260-71, 2015. PMID: 25784246.
- Evans SE. (Selected for ATS CME program) ATS Virtual Symposium: Coping with Candida infections. Proc Am Thorac Soc 7(3):197-203, 2010. PMID: 20463248.
- Evans SE, Xu Y, Tuvim MJ, Dickey BF. Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol 72:413-35, 2010. PMID: 20148683.
- Safdar A, Shelburne SA, Evans SE, Dickey BF. Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf 8(4):435-49, 2009. PMID: 19538104.
- Evans SE, McDonald FS, Scanlon PD.. An approach to pulmonary function testing. Respiratory Review 2(6):40-44, 2006.
- Evans SE, Scanlon PD.. Current practice in pulmonary function testing. Mayo Clin Proc 78(6):758-763, 2003. PMID: 12934788.
Editorials
- Cheng GS, Evans SE. The paradox of immunosuppressants and COVID-19. Eur Respir J 59(4), 2022. PMID: 34795039.
- Yuan X, Ferrari D, Mills T, Wang Y, Czopik A, Doursout MF, Evans SE, Idzko M, Eltzschig HK. Editorial: Purinergic Signaling and Inflammation. Front Immunol 12:699069, 2021. PMID: 34093597.
Book Chapters
- Sagar AES, Evans SE. Pneumonia in the Cancer Patient. In: Oncologic Critical Care. Springer Nature: Heidelberg, 2019.
- Evans SE, Safdar A. Pneumonia in the Critically Ill Cancer Patient. In: Cancer Critical Care. Springer Science + Business Media: New York, 2018.
- Shannon VR, Eapen GA, Jimenez CA, Grosu HB, Morice RC, Bashoura L, Evans SE, Adachi R, Kroll M, Faiz SA, Balachandran DD, Pravinkumar SE, Dickey BF. Respiratory Complications. In: Holland-Frei Cancer Medicine. 9. John Wiley and Sons, Inc: Hoboken, NJ, 1781-1805, 2017.
- Evans SE, Safdar A. Pneumonia and Other Lung Infections. In: Principles and Practice of Cancer Infectious Diseases. Humana Press: New York, 2011.
- Evans SE, Scanlon PD, Culver BH. Pulmonary Function Testing. In: Comprehensive Respiratory Medicine, 3rd Edition. 3. Elsevier: Philadelphia, PA, 147-155, 2008.
- Evans SE, Limper AH. Chemotherapy-Induced Lung Disease - An Evidence-Based Approach. In: Oncology: An Evidence-Based Approach. Springer-Verlag: New York, 1401-1410, 2005.
- Evans SE, Limper AH. HIV: North American Perspective. In: Tropical and Parasitic Infections in the ICU. Kluwer Academic Publishers: Norwell, MA, 127-144, 2004.
Grant & Contract Support
| Title: | Interrogation of host gene expression response predicts the etiology of infections pneumonia |
| Funding Source: | NIH/NCRR |
| Role: | Principal Investigator |
| Title: | Mechanisms of stimulated innate resistance that protect against pneumonia among leukemia patients |
| Funding Source: | Leukemia Research Foundation |
| Role: | Principal Investigator |
| Title: | Mechanisms of inducible innate immunity that protect broadly against pneumonia |
| Funding Source: | Charles E. Culpeper Foundation/Partnership for Cures |
| Role: | Principal Investigator |
| Title: | Epithelial mechanisms of inducible lung innate immunity that protect broadly against pneumonia |
| Funding Source: | MD Anderson Physician-Scientist Program/NIH Cancer Center Support Grant |
| Role: | Principal Investigator |
| Title: | Stimulated innate resistance of the lungs to bioterror pathogens |
| Funding Source: | NIH/NIAID |
| Role: | Project Leader |
| Title: | Induction of the lung innate immunity that protects broadly against pneumonia during leukemia therapy |
| Funding Source: | MD Anderson Leukemia SPORE |
| Role: | Principal Investigator |
| Title: | Interrogation of host gene expression response predicts the etiology of infectious pneumonia |
| Funding Source: | NIH Division of Loan Repayment |
| Role: | Principal Investigator |
| Title: | Inducible innate resistance of the lung epithelium to infection |
| Funding Source: | MD Anderson/NIH Cancer Center Support Grant, Multidisciplinary Research Project |
| Role: | Co-Investigator |
| Title: | Induced resistance to influenza A infection by cooperative TLR2/6 and TLR9 signaling |
| Funding Source: | The Cyrus Family Foundation |
| Role: | Principal Investigator |
| Title: | Mechanisms of inducible epithelial resistance to cancer-related pneumonia |
| Funding Source: | TJ Martell Foundation |
| Role: | Principal Investigator |
| Title: | Epithelial mechanisms of inducible resistance to AML-associated pneumonia |
| Funding Source: | NIH/NHLBI |
| Role: | Principal Investigator |
| Title: | Expanding the market and success rates for myeloablative cancer treatments using PUL-042, an innate immune stimulant |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| Title: | Inducible epithelial antiviral resistance to prevent asthma |
| Funding Source: | NIH/NHLBI |
| Role: | Principal Investigator |
| Title: | Cyrus Scholar Award |
| Funding Source: | The Cyrus Family Foundation |
| Role: | Principal Investigator |
| Title: | Inducible epithelial resistance: a program investigating mechanisms to protect against acute and chronic complications of pneumonia |
| Funding Source: | NIH/NHLBI |
| Role: | Principal Investigator |
| Title: | Synergistic induction of epithelial mitochondrial reactive oxygen species to prevent pneumonia |
| Funding Source: | Cyrus Family Foundation |
| Role: | Principal Investigator |
| Title: | Epithelial mechanisms of inducible resistance to AML-associated pneumonia |
| Funding Source: | NIH/NHLBI |
| Role: | Principal Investigator |