S. Egbert Pravinkumar, MD, FRCP, EDIC
Department of Critical Care and Respiratory Care, Division of Anesthesiology, Critical Care, and Pain Medicine
Present Title & Affiliation
Primary Appointment
Professor, Department of Critical Care, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Medical Director, Department of Critical Care, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Adjunct Professor, Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology and Critical Care, UT Health McGovern Medical School, Houston, TX
Education & Training
Degree-Granting Education
| 2006 | American College of Chest Physicians, Chicago, IL, USA, FCCP, Pulmonary/ Critical Care Medicine |
| 2004 | Royal College of Physicians of Ireland, Dublin, IRL, FRCP, Pulmonary/ Internal Medicine |
| 2004 | European Society of Intensive Care Medicine, Brussels, BEL, EDIC, Critical Care Medicine |
| 2001 | University of Leeds, Leeds, GBR, PG Cert. Health Res, Healthcare Research |
| 1996 | Royal College of Physicians of Ireland, Dublin, IRL, MRCP, Pulmonary Medicine/ Internal Medicine |
| 1991 | Stanley Medical College and University Hospital, University of Madras, Madras, IND, MD, Doctor of Medicine |
Postgraduate Training
| 2000-2001 | Clinical Fellowship, Critical Care and Anesthesiology, University of Aberdeen Critical Care Rotation (Aberdeen Royal Infirmary and University Hospital), Aberdeen |
| 1996-2000 | Clinical Fellowship, Pulmonary Medicine, Leeds Teaching Hospitals Rotation (The Leeds General Infirmary/ St. James' University Hospital), Leeds, England |
| 1993-1996 | Clinical Residency, Pulmonary and Internal Medicine, Prince Charles Hospital/ Bishop Auckland General Hospital/ Princess Royal Hospital, England and Wales |
Board Certifications
| 2004 | Critical Care Medicine (European Union), European Board of Intensive Care Medicine, European Society of Intensive Care Medicine, Brussels, Belgium |
| 2002 | Critical Care Medicine (UK), Intercollegiate Board for Training in Intensive Care Medicine, London, United Kingdom |
| 2002 | Pulmonary Medicine, The Specialist Training Authority of Medical Royal Colleges, London, United Kingdom |
| 2002 | Internal Medicine, The Specialist Training Authority of Medical Royal Colleges, London, United Kingdom |
| 1996 | Royal College of Physicians, Dublin, Ireland |
Experience & Service
Academic Appointments
Adjunct Associate Professor, Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology and Critical Care, The University of Texas Health Science Center, UT Health, Houston, TX, 2012 - 2017
Associate Professor, Department of Critical Care, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2016
Selected Publications
Peer-Reviewed Articles
- Raad I, Chaftari AM, Zakhour R, Jordan M, Al Hamal Z, Jiang Y, Yousif A, Garoge K, Mulanovich V, Viola GM, Kanj S, Pravinkumar E, Rosenblatt J, Hachem R. Successful Salvage of Central Venous Catheters in the Setting of Catheter Related or Central Line Associated Bloodstream Infections Using Catheter Lock Consisting of Minocycline, EDTA and 25% Ethanol. Antimicrob Agents Chemother 60(6):3426-32, 2016. e-Pub 2016. PMID: 27001822.
- Gutierrez C, Pravinkumar E, Balachandran D, Schneider V. Fatal Hemorrhagic Pneumonia: Don't Forget Stenotrophomonas Maltophilia. Respir Med Case Rep 19:12-4, 2016. e-Pub 2016. PMID: 27358764.
- Esquinas AM, Egbert Pravinkumar S, Scala R, Gay P, Soroksky A, Girault C, Han F, Hui DS, Papadakos PJ, Ambrosino N, on behalf of the International NIV Network. Noninvasive Mechanical Ventilation in High Risk Pulmonary Infections: A Clinical Review. Eur Respir Rev 23(134):427-438, 2014. PMID: 25445941.
- Debiane L, Hachem RY, Al Wohoush I, Shomali W, Bahu RR, Jiang Y, Chaftari AM, Jabbour J, Al Shuaibi M, Hanania A, Pravinkumar SE, Schuetz P, Raad I. The Utility of Proadrenomedullin and Procalcitonin in Comparison to C-Reactive Protein as Predictors of Sepsis and Bloodstream Infections in Critically Ill Patients With Cancer. Crit Care Med 42(12):2500-2507, 2014. e-Pub 2014. PMID: 25083975.
- Jamal MA, Rosenblatt JS, Hachem RY, Ying J, Pravinkumar E, Nates JL, Chaftari AM, Raad II. Prevention of Gram-Negative Bacterial Biofilm on Minocycline/Rifampin impregnated catheters sequentially coated with Chlorhexidine. Antimicrob Agents Chemother 58(2):1179-82, 2014. e-Pub 2013. PMID: 24165191.
- Bruno JJ, Dee BM, Anderegg BA, Hernandez M, Pravinkumar SE. US Practitioner Opinions and Prescribing Practices Regarding Corticosteroid Therapy for Severe Sepsis and Septic Shock. J Crit Care 27(4):351-361, 2012. e-Pub 2012. PMID: 22341726.
- Bruno JJ, Hernandez M, Ghosh S, Pravinkumar SE. Critical Illness-Related Corticosteroid Insufficiency in Cancer Patients. Support Care Cancer 20(6):1159-1167, 2012. e-Pub 2011. PMID: 21604086.
- Chaftari AM, Kassis C, El Issa H, Al Wohoush I, Jiang Y, Rangaraj G, Caillouet B, Pravinkumar SE, Hachem RY, Raad II. Novel approach using antimicrobial catheters to improve the management of central line-associated bloodstream infections in cancer patients. Cancer 117(11):2551-2558, 2011. e-Pub 2010. PMID: 24048803.
- Ramos ER, Reitzel R, Jiang Y, Hachem RY, Chaftari AM, Chemaly RF, Hackett B, Pravinkumar SE, Nates J, Tarrand JJ, Raad II. Clinical Effectiveness and Risk of Emerging Resistance Associated with Prolonged Use of Antibiotic-Impregnated Catheters: More than 0.5 Million Catheter Days and 7 Years of Clinical Experience (Featured Article). Crit Care Med 39(2):245-251, 2011. e-Pub 2010. PMID: 21057308.
- Bilen MA, Waguespack SG, Tannir NM, Pravinkumar SE, Tamboli P, Tu SM. Multisystem Crisis in a Patient with Presumptive Renal Cell Carcinoma. Clin Genitourin Cancer 6(2):128-30, 2008. PMID: 18824438.
- Pravinkumar E, Webster NR. HIT/HITT and Alternate Anticoagulation: Current Concepts. Anesthesia File- CME 20(9):155.0302, 2003.
- Pravinkumar E, Webster NR. HIT/HITT and Alternate Anticoagulation: Current Concepts. BJA International Journal of Anaesthesia, South African Excerpts Edition 3(4):255-264, 2003.
- Pravinkumar E. Peer review and appeal: flawed but trusted?. Lancet 362(9385):747, 2003. PMID: 12957106.
- Pravinkumar E, Webster NR. HIT/HITT and Alternative Anticoagulation: Current Concepts. Br J Anaesth 90(5):676-85, 2003. PMID: 12697598.
Other Articles
- Pravinkumar SE Demise of Drotrecogin Alpha Activated. Critical Care Bulletin 1(5):1-2, 2012.
- Warren ML, Pravinkumar SE, Frankel S, Ryan S, Nguyen V, Garcia B, Thomas B, Withers L, Nguyen Q The Development and Implementation of an Early Mobilization Program for Critically Ill Adult Patients. Evidence Based Practice, UTMDACC 1(4), 2011.
Editorials
- Pravinkumar SE. A Face that Matters in Distress: Interface Selection for Acute Noninvasive Ventilation. Crit Care Med 37(1):344-346, 2009. PMID: 19112296.
Abstracts
- Warren ML, Pravinkumar SE, Frankel S, Ryan S, Nguyen V, Garcia R, Thomas M, Withers L, Nguyen Q.. The Implementation and Evaluation of an Early Mobilization Program for Critically Ill Adult Oncology Patients (Texas-SCCM's Alan I. Fields Award for Outstanding Multidisciplinary Program). Crit Care Med 39(12):182, 2011.
- Nates JL, Rathi N, Haque S, Gaeta S, Pravinkumar SE, Botz G, Chen K, Crommett J, Calabrese D, De Villalobos D, Malik I, Price K. ICU Triage Improves Patient Flow and Resource Utilization. CHEST 140(4):357A, 2011.
- Pravinkumar SE, Nigam R, Hwu P, Davies MA, Price K. Intensive Care Resource Utilization for High Dose Interleukin-2 Therapy: A 3-Year Experience from a Large Oncologic ICU. Can Respir J 18(Suppl A):19A, 2011.
- Nates JL, Perego C, Finch C, Chemaly R, Jordan V, Terrell J, Pravinkumar SE, Raad I, Price K. Ventilator-Associated Pneumonia (VAP) Can Be Eradicated. Successful VAP prevention Program in a Comprehensive Cancer Center Surgical ICU(Texas Hospital Association's First Bill Aston Award for Quality). Crit Care Med 38(12):S411, 2010.
- Dee BM, Lal L, Pravinkumar SE.. Effect of Nebulized Dornase Alfa on Pulmonary Gas Exchange in Critically Ill Stem Cell Transplant Recipients. Biol Blood Marrow Tr 16(2):S317, 2010.
- Bruno JJ, Hernandez M, Pravinkumar SE. Current Opinions and Prescribing Practices for Corticosteroid Therapy in Severe Sepsis and Septic Shock: Survey of US Practitioners. Crit Care Med 37(12), 2009.
- Dee BM, Lal L, Pravinkumar SE. Effect of Inhaled Dornase Alfa on Gas Exchange in Critically Ill Adult Cancer Patients. Crit Care Med 37(12):A195, 2009.
- Pravinkumar SE, Warren ML, Bruno JJ, Nwankwo C, Finch CG, Price KJ. Implementation of the Institute for Healthcare Improvement Global Trigger Tool in an Oncological ICU: Pilot Data. CHEST 136(4):27S-b, 2009.
- Sachdeva KS, Lal AP, Salahudeen A, Pravinkumar SE, Davis M. Chronic Kidney Disease induced by IL-2 as a chemotherapeutic agent. JASN - Renal Week Abstracts 2009, 2009.
- Mulanovich VE, Perego CL, Borchardt R, Pravinkumar SE, Chemaly RF, Rolston KVI, Adachi JA. Antimicrobial Stewardship Project in the Intensive Care Unit: Impact on Quality of Care and Patient Safety. CS&E: Building the Bridge at the Quality Chasm, 2009.
- Ghosh S, Finch CG, Champlin R E, Pravinkumar SE. Comparison and Cost Effectiveness of Bronchoscopic and Non-Bronchoscopic Bronchoalveolar Lavage in Hematological Malignancies and Stem Cell Recipients. Biol Blood Marrow Tr 15(2):91-92, 2009.
- Ramos ER, Jiang Y, Hachem R, Reitzel R, Pravinkumar E, Nates J, Tarrand J, Raad I. The Risk of Emerging Resistance Associated with Prolonged Use of Antibiotic Coated Catheters: A Seven Year Experience and >0.5 Million Catheter Days (2009 Sepsis Specialty Award). Critical Care Medicine 36(12 (Suppl)):A15, 2008. PMID: 19112296.
- Ghosh S, Finch C, Champlin RE, Kebriaei P, Giralt SA, Pravinkumar SE. Usefulness of Bronchoscopic Lavage in Intensive Care Unit for Critically Ill Stem Cell Recipients with Pulmonary Infiltrates. Biol Blood Marrow Tr 14(2):98, 2008.
- Bruno JJ, Hernandez M, Chen K, Pravinkumar SE. Influence of Corticosteroids on Cosyntrophin Stimulation Test in Oncology Patients with Severe Sepsis or Septic Shock. Crit Care Med 35(12):A274, 2007.
- Bruno JJ, Hernandez M, Ghosh S, Pravinkumar SE. Serum Cortisol and Response to High-dose Cosyntrophin Stimulation in Oncology Patients with Severe Sepsis or Septic Shock. Crit Care Med 35(12):A257, 2007.
- Pravinkumar SE, Ghosh S, Price KJ, Finch C. Unplanned Extubations and Outcome in Oncological Intensive Care Unit: 1-Year Experience. Respirology 12(4):A216, 2007.
- Finch C, Ghosh S, Price KJ, Pravinkumar SE. Post-operative Mechanical Ventilation in Oncological Surgical Intensive Care Unit: Review of Institute of Health Improvements Adverse Event Criteria. Respir Care 52(11):1612, 2007.
- Ghosh S, Finch C, Price KJ, Pravinkumar SE. Platelet Levels and Safety of Bronchoalveolar Lavage in Critically Ill Cancer Patients. CHEST 132(4):568S, 2007.
- Nates JL, Wakefield C, Pravinkumar SE, Price KJ, Perego C, Hackett B, Chemaly R, Raad I, Finch C. Ventilator Associated Pneumonia Rates in Surgical ICU: Surveillance and Interventions in a Comprehensive Cancer Center (2007 Respiratory Specialty Award)). Crit Care Med 34(12):A94, 2006.
- Nates JL, Pravinkumar SE, Price KJ, Finch C, Lee L, Frederick F, Berkheiser M, Baldwin L. Environmental Sampling During High Frequency Ventilation. Crit Care Med 34(12):A88, 2006.
- Bolden M, Finch C, Pravinkumar SE, Mejia D, Nates JL, Price KJ. Role of Respiratory Therapist in the ICU Outreach: Impact of Respiratory Therapist Transitional Service in a Major Cancer Center. Respir Care 51(11):1281, 2006.
- Pravinkumar SE, Finch C, Binns N, Kannaeth T, Denning I, Nates JL, Price KJ. Bronchoscopic and Nonbronchoscopic Lavage in Critically Ill Cancer Patients with Lung Infiltrates: Diagnostic Yield and Cost-effectiveness. Respir Care 51(11):1281, 2006.
- Finch C, Pravinkumar SE, Nates JL, Geevarghese G, Perkins R, Han C, Price KJ. Safety of Non-Bronchoscopic BAL Performed by Respiratory Therapist: Experience from Large Oncological ICU. Respir Care 51(11):1281, 2006.
- Pravinkumar SE, Finch C, Price KJ, Nates JL. Respiratory Therapist Led Early VAP Surveillance: A Proactive Strategy in an Oncological ICU. Respir Care 51(11):1281, 2006.
- Pravinkumar E, Watt A, Galley H, Cuthbertson B, Webster N. Effects of Recombinant Surfactant Protein-C and Elastase Inhibitor on Neutrophil Apoptosis. Crit Care 8(Suppl.1):S54, 2004.
- Hill KM, Muers MF, Pravinkumar E, Thorpe JA, MacDonald W. A Comparison of Shuttle Walking Test (SWT) and Maximal Oxygen Consumption (V02 Peak) Measured on a Treadmill as Predictors of Outcome Following Lung Resection. 10th European Respiratory Society Annual Congress, 2000.
- Harkins K, Pravinkumar E, Wanklyn P. Cough Reflex and Pneumonia in Acute Stroke (2000 Respiratory Specialty Award). British Association of Stroke Physicians Annual Congress, 2000.
- Hill KM, Pravinkumar E, Macdonald W, Muers MF. Can the Distance Walked During the Shuttle Walking Test Predict O2 Uptake?. Thorax 54(Suppl.3):A78, 1999.
Book Chapters
- Pravinkumar, S.E. Noninvasive Mechanical Ventilation in Acute Respiratory Failure due to Pandemic Influenza A H1N1 Infection. In: Noninvasive Ventilation in High-Risk Infections and Mass Casualty Events. 1. Springer-Verlag Wien 2014: Germany, 153-156, 2014.
- Depuyt P.O, Pravinkumar S.E. Noninvasive Mechanical Ventilation in Patients with Hematological Diseases. In: Noninvasive Mechanical Ventilation in High-Risk Infections and Mass Casualty Events. 1. Springer-Verlag Wien 2014: Germany, 181-188, 2014.
- Shannon V.R, Eapen G.A, Jimenez. C.A, Morice R.C, Travis E.L, Bashoura. L, Safdar. A, Evans S.E, Adachi. R, Faiz S.A, Balachandran D.D, Nates J.L, Pravinkumar S.E, Dickey B.F. Complications of Cancer and their Treatment: Respiratory Complications. In: Holland-Frei Cancer Medicine e.8. 8. BC Decker: USA, 1849-1879, 2010.
- Pravinkumar S.E. Noninvasive Positive Pressure Ventilation in Acute Hypoxemic Respiratory Failure and in Cancer Patients. In: Noninvasive Mechanical Ventilation - Theory, Equipment, and Clinical Applications. 1. Springer-Verlag: Berlin Heidelberg, Germany, 249-256, 2010.
- Pravinkumar S.E, Puana R, Nates J.L. Ventilación de Positiva Presión No Invasiva en Fallo Respiratorio Agudo en Pacientes con Cáncer. In: Ventilación Mecánica No Invasiva En Inmunocomprometidos- Hematologia Oncologia Transplantados. 1. Axon, Espanol: Spain, 369-382, 2009.
- Puana R, Pravinkumar S.E, Nates J.L. Ventilación Mecánica Invasiva en Pacientes con Cáncer con Fallo Respiratorio Agudo. In: Ventilación Mecánica No Invasiva En Inmunocomprometidos- Hematologia Oncologia Transplantados. 1. Axon, Espanol: Spain, 359-368, 2009.
- Shannon V.R, Eapen G.A, Jimenez. C.A, Morice R.C, Travis E.L, Bashoura. L, Safdar. A, Adachi. R, Pravinkumar S.E, Dickey B.F. Complications of Cancer and their Treatment: Respiratory Complications. In: Holland-Frei Cancer Medicine e.7. 7. BC Decker: USA, 2150-2173, 2006.
- Pravinkumar E. T-Cell Immunity and Sepsis, Immunity and Inflammation. In: Critical Care Focus. BMJ Publishing Group: London, United Kingdom, 65-76, 2003.
Letters to the Editor
- Esquinas AM, Pravinkumar E. Lung cancer and intensive care admission: Is this a matter for ICU practice and policy?. Asia Pac J Clin Oncol 12: e356, 2016.
- Esquinas AM, Pravinkumar E. Palliative Radiotherapy for Malignant Airway Obstruction Requiring mechanical Ventilation: Answer or Anguish?. J Thorac Oncol 9: e54, 2014.
- Esquinas AM, Pravinkumar E. Intensive Care Unit Mortality in Solid Tumor Patients: Is This Predictable and Preventable?. Support Care Cancer 22: 289-90, 2014.
- Esquina AM, Patel B, Pravinkumar E. High-frequency chest wall oscillation in infective exacerbation of COPD: Is airway secretion clearance the cornerstone?. Clin Rehabil 28: 206-207, 2014.
- Esquinas AM, Pravinkumar E. CPAP in Obstructive Sleep Apnea and Atrial Flutter-Fibrillation: Is This Truly Two for the Price of One?. Chest 144: 713, 2013.
- Esquinas AM, Consentini R, Pravinkumar E, Dikmen Y. Effectiveness of Helmet Non-invasive Ventilation with External PEEP. Minerva Anestesiol 79: 697-8, 2013.
- Esquinas AM, Pravinkumar SE. Malfunction of Heat and Moisture Exchanger Filters: Causality or Unresolved Problem?. J Anaesthesiol Clin Pharmacol 29: 285-6, 2013.
- Esquinas AM, Özyilmaz E, Pravinkumar E. Obstructive Sleep Apnea and Asthma: Is it Just A Matter Of CPAP. Tuberk Toraks 61: 250-251, 2013.
- Esquinas Rodriguez AM, Ambrosino N, Pravinkumar E. Noninvasive Mechanical Ventilation for Prevention of Post-extubation Respiratory Failure: Prevention Only by Selection. Respir Care 57: 1357, 2012.
- Esquinas Rodriguez AM, Pravinkumar E. Mechanical insufflation-exsuflation in prevention of post-extubation acute respiratory failure: most welcome but be cautious in critically ill patients. Crit Care 16: 431, 2012.
- Pravinkumar SE. Physician Practice Variation in Critical Care: A Stumbling Block. Crit Care Med 37: 1178-1179, 2009.
- Pravinkumar SE. Drotrecogin Alfa (Activated): Surviving Sepsis by Chance. Am J Respir Crit Care Med 177: 669, 2008.
- Pravinkumar E. Balance of Inflammation in Sepsis. Am J Respir Crit Care Med 169: 655-656, 2004.
- Pravinkumar E. Cardiovascular Management of Septic Shock. Crit Care Med 32: 315, 2004.
- Pravinkumar E. HIT/HITT and Alternative Anticoagulation: Current Concepts. Br J Anaesth 91: 606-607, 2003.
- Pravinkumar E. Rate and Rhythm are Important in Critically Ill Patients. BMJ 327: 931-932, 2003.
- Pravinkumar E. Staging of Non-small Cell Lung Cancer with Integrated PET and CT. N Engl J Med 349: 1188-1190, 2003.
- Pravinkumar E, Webster NR. HIT/HITT and Alternative Anticoagulation: Current Concepts. Br J Anaesth 91: 445-446, 2003.
- Pravinkumar E. Obesity in General Elective Surgery. Lancet 362: 576-577, 2003.
- Pravinkumar E. Career Achievement with Stability Outside Work is True Success. BMJ, 2003.
- Pravinkumar E. Screening 85 plus: Justification Unclear. BMJ 327: 131-132, 2003.
- Pravinkumar E. Indicators of Sepsis and Organ Failure: An Elusive Zone. Chest 123: 2043-2049.