Senthil Damodaran, MD, PhD.
Department of Breast Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Postgraduate Training
| 2013-2015 | Fellowship, Breast Medical Oncology, The Ohio State University, Columbus, OH |
| 2012-2015 | Postdoctoral Fellow, (Mentor – Sameek Roychowdhury), The Ohio State University, Columbus, OH |
| 2011-2013 | Fellowship, Medical Oncology, The Ohio State University, Columbus, OH |
| 2008-2011 | Residency, Internal Medicine, University at Buffalo, Buffalo, NY |
Board Certifications
| 2014 | Medical Oncology, American Board of Internal Medicine |
| 2012 | Internal Medicine, American Board of Internal Medicine |
Experience & Service
Academic Appointments
Clinical Instructor House Staff, The Ohio State University, Buffalo, NY, 2008 - 2011
Graduate Research Assistant, University at Buffalo, Buffalo, NY, 2002 - 2008
Institutional Committee Activities
Member, Hematology and Oncology P and T Committee, The Ohio State University–James Cancer Center, 2013 - 2014
Elected Member, Residents Task Force, University at Buffalo, 2010 - 2011
Elected Member, Resident’s Advisory Committee, University at Buffalo, 2008 - 2010
Honors & Awards
| 2015 | Scientific Career Development Retreat, Conquer Cancer Foundation |
| 2014 | Young Investigator Award, American Society of Clinical Oncology |
| 2014 | Pelotonia Postdoctoral Award, Ohio State University - James Cancer Center |
| 2013 | Obrine-Weaver Award, Ohio State University |
| 2013 | ASCO/AACR Workshop on Methods in Clinical Cancer Research, ASCO/AACR |
| 2013 | Fellows Recognition Program, National Comprehensive Cancer Network |
| 2011 | Outstanding Outgoing Resident, William M. and Stanley A.Bukowski Award |
| 2009 | Outstanding Intern, Norman Chassin Award |
| 2009 | Second Place, Internal Medicine Quiz Competition, University at Buffalo |
| 2009 | First Place, Internal Medicine Quiz Competition, University at Buffalo |
| 2006 | GSA Scholarly Publication Award, University at Buffalo |
| 2006 | Eastern Atlantic Student Research Forum, Travel Award, University of Miami |
| 2003 | SUNY GSEU Doctoral Award, University at Buffalo |
| 2001 | Dean’s nomination, “Young Fellowship Award in Science”, Indian Institute of Sciences, India |
| 2000 | Outstanding oral presentation, “Lymphomas”, Department of Surgery, Madras Medical College, India |
| 1996 | First place, “Cardiovascular Physiology Quiz”, Institute of Physiology and Experimental Medicine, Madras Medical College, India |
| 1995 | Second place, “Renal Physiology Quiz”, Institute of Physiology and Experimental Medicine, Madras Medical College, India |
| 1995 | Chief Minister’s Medical Scholarship |
Selected Publications
Peer-Reviewed Articles
- Meric-Bernstam F, Zheng X, Shariati M, Damodaran S, Wathoo C, Brusco L, Demirhan ME, Tapia C, Eterovic AK, Basho RK, Ueno NT, Janku F, Sahin A, Rodon J, Broaddus R, Kim TB, Mendelsohn J, Mills Shaw KR, Tripathy D, Mills GB, Chen K. Survival outcomes by TP53 mutation status in metastatic breast cancer. JCO Precis Oncol 2018, 2018. e-Pub 2018. PMID: 30035249.
- Datta J, Damodaran S*, Parks H, Ocrainiciuc C, Miya J, Yu L, Gardner EP, Samorodnitsky E, Wing MR, Bhatt D, Hays J, Reeser JW, Roychowdhury S. Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398. Mol Cancer Ther 16(4):614-624, 2017. e-Pub 2017. PMID: 28255027.
- Damodaran S, Miya J, Kautto E, Zhu E, Samorodnitsky E, Datta J, Reeser JW, Roychowdhury S. Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations. J Mol Diagn 17(5):554-9, 2015. PMID: 26320871.
- Samorodnitsky E, Jewell BM, Hagopian R, Miya J, Wing MR, Lyon E, Damodaran S, Bhatt D, Reeser JW, Datta J, Roychowdhury S. Evaluation of Hybridization Capture Versus Amplicon-Based Methods for Whole-Exome Sequencing. Hum Mutat 36(9):903-14, 2015. e-Pub 2015. PMID: 26110913.
- Samorodnitsky E, Datta J, Jewell BM, Hagopian R, Miya J, Wing MR, Damodaran S, Lippus JM, Reeser JW, Bhatt D, Timmers CD, Roychowdhury S. Comparison of custom capture for targeted next-generation DNA sequencing. J Mol Diagn 17(1):64-75, 2015. PMID: 25528188.
- Damodaran S, Mrozek E, Liebner D, Kendra K. Focal takotsubo cardiomyopathy with high-dose interleukin-2 therapy for malignant melanoma. J Natl Compr Canc Netw 12(12):1666-70; quiz 1670, 2014. PMID: 25505207.
- Zhao W, Damodaran S, Villalona-Calero MA. From single-gene to multiplex analysis in lung cancer, challenges and accomplishments: a review of a single institution's experience. Lung Cancer Manag 4(3):315-324, 2014. PMID: 25580159.
- Damodaran S, Majumder S, Ramaswamy R. Endocrine resistance: mechanisms and therapeutic targets. Clinical Investigation 3(7):681-690, 2013.
- Damodaran S, Olson EM. Targeting the human epidermal growth factor receptor 2 pathway in breast cancer. Hosp Pract (1995) 40(4):7-15, 2012. PMID: 23299030.
- Damodaran S, Bellavia T, Sait SN, Wang ES, Wetzler M, Khushalani NI. Acute myeloid leukemia secondary to oxaliplatin treatment for esophageal cancer. Clin Colorectal Cancer 11(2):151-4, 2012. e-Pub 2011. PMID: 22133502.
- Damodaran S. Cocaine and beta-blockers: the paradigm. Eur J Intern Med 21(2):84-6, 2010. e-Pub 2009. PMID: 20206876.
- Damodaran S, Wood TD, Nagarajan P, Rabin RA. Evaluating peptide mass fingerprinting-based protein identification. Genomics Proteomics Bioinformatics 5(3-4):152-7, 2007. PMID: 18267296.
- Damodaran S, Rabin RA. Minimizing variability in two-dimensional electrophoresis gel image analysis. OMICS 11(2):225-30, 2007. PMID: 17594240.
- Damodaran S, Dlugos CA, Wood TD, Rabin RA. Effects of chronic ethanol administration on brain protein levels: a proteomic investigation using 2-D DIGE system. Eur J Pharmacol 547(1-3):75-82, 2006. e-Pub 2006. PMID: 16978605.
- Vadivelu MK, Damodaran S Solomon J, Rajaseharan A. Distribution of ABO blood groups in acute leukaemias and lymphomas. Ann Hematol 83(9):584-7, 2004. e-Pub 2004. PMID: 15175895.
Invited Articles
- Damodaran S and Sameek Roychowdhury. Genomics and Precision Cancer Medicine. Oncology & Hematology Review 11(2):145-6, 2015.
Abstracts
- Abuhadra N, Hess KR, Litton JK, Rauch GM, Thompson AM, Lim B, Adrada BE, Mittendorf EA, Damodaran S, Candelaria RP, Arun B, Yang WT, Ueno NT, Santiago L, Murthy RK, Ibrahim NK, Sahin AA, Symmans WF, Moulder SL, Huo L. Beyond TILs: Predictors of pathologic complete response (pCR) in triple-negative breast cancer (TNBC) patients with moderate tumor-infiltrating lymphocytes (TIL) receiving neoadjuvant therapy. American Society of Clinical Oncology, Annual Meeting, Chicago, 2019.
- Seth S, Crespo J, Huo L, Thompson AM, Mittendorf EA, Hess KR, Litton JK, Rauch GM, Adrada BE, Damodaran S, Candelaria RP, Arun B, Yang WT, Santiago L, Murthy RK, Sahin AA, Symmans WF, Moulder SL, Ueno NT, Lim B. Evaluation of predictive biomarkers for AR therapy and to identify the LAR subtype of TNBC. American Society of Clinical Oncology, Annual Meeting, Chicago, 2019.
- Damodaran S, Symmans F, Helgason T, Mittendorf E A, Tripathy D, Hess K, Litton J, Moulder.. A Phase II Trial Of Mirvetuximab Soravtansine In Patients With Localized Triple-Negative Breast Cancer (TNBC) With Tumors Predicted Insensitive To Standard Neoadjuvant Chemotherapy (NACT) Including A Lead-In Cohort To Establish Activity In Patients With Metastatic TNBC. European Society of Medical Oncology, Congress, Madrid, Spain, 2017.
- Damodaran S, Dlugos CA and Rabin RA. Effects of chronic ethanol administration in zebrafish: proteomic study using 2-D DIGE. Sigma Xi Research Day, University at Buffalo, 2006.
- Damodaran S, Dlugos CA and Rabin RA. Effects of chronic ethanol administration in zebrafish: proteomic study using 2-D DIGE. Eastern Atlantic Student Research Forum, Miller School of Medicine, Miami, 2006.
- Damodaran S and Rabin RA. Mechanism of tolerance to ethanol: proteomic study in zebrafish. Pharmacology Sciences Day. University at Buffalo, 2004.
- Vadivelu MK, Damodaran S, Solomon J, Rajaseharan, A. Hospital based retrospective analysis of pediatric leukemias (acute) and lymphomas. 41st Annual National Student Research Forum, UTMB, Galveston, 2000.
Book Chapters
- Damodaran S, Tripathy D. Breast Cancer. In: Handbook of Targeted Cancer Therapy and Immunotherapy, 2018.
- Damodaran S, Berger MF, Roychowdhury S. Clinical Tumor Sequencing: Opportunities and Challenges for Precision Cancer Medicine. In: Am Soc Clin Oncol Educ Book, e175-82, 2015.
- Damodaran S and Cataland, S R. Excessive Bleeding with Normal Prothrombin Time, Partial Thromboplastin Time, and Platelet Count. In: The Coagulation Consult–A Case-Based Guide. Springer Press, 87-97, 2014.
Grant & Contract Support
| Title: | Genomic and proteomic alterations mediate secondary resistance to fibroblast growth factor inhibition in cancers |
| Funding Source: | Pelotonia Postdoctoral Award |
| Role: | Principal Investigator |
| Title: | Genomic and proteomic alterations mediate secondary resistance to fibroblast growth factor inhibition in cancers |
| Funding Source: | ASCO Young Investigator Award |
| Role: | Principal Investigator |