Associate Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
Faculty, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, Houston, TX
Faculty, Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Tecnologico de Monterrey School of Medicine, Monterrey
My research is focused on airway inflammation and its role in airway epithelial carcinogenesis. Tumor-promoting inflammation is a cancer hallmark, and it is considered an enabling characteristic due to its contributions to the acquisition of core hallmark capabilities. Cigarette smoking is the principal cause of lung carcinogenesis. However, several studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer compared to smokers with comparable cigarette exposure but without COPD. This suggests a strong link between COPD-related airway inflammation and lung cancer. In addition, it is known that mutant epithelial cells begin to edit the microenvironment as soon as they transform but the exact mechanisms involved in this immuno-editing process from escaping the immunosurveillance to tumor progression still not well understood. We have previously shown that the numerous cytokines released during inflammation (oncogene-driven or COPD-related) promote lung tumorigenesis in a genetic mouse model of lung cancer. We are currently dissecting the sex- and cell-type specific mechanisms responsible for this phenomenon with genetic and pharmacologic approaches. This will provide a better understanding of the role of specific inflammatory pathways in lung carcinogenesis, and subsequently allow preclinical testing of the efficacy of anti-inflammatory agents in preventing lung cancer in high-risk population or patient with early metaplastic lesions. This would also have a major impact on the treatment of patients with lung cancer by providing the basis for rationally directed immunotherapeutic modalities to improve the efficacy of currently available treatment regimens.
|1996||Shaheed Beheshti University of Medical Sciences (SBUMS), Tehran, IRN, MD, Medical School|
|2006-2007||Research Fellowship, Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX|
|2004-2006||Research Fellowship, Pulmonary and Critical Care Section, Baylor College of Medicine, Houston, TX|
|2000-2003||Research Fellowship, Research Center for Gastroenterology and Liver Diseases (RCGLD), SBUMS, Tehran|
|1994-1996||Internship, Shaheed Beheshti University of Medical Sciences (SBUMS), Tehran|
Assistant Professor, Department of Pulmonary Medicine - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2018
Non-Tenure Track Assistant Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - 2012
Instructor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2009
|2017||Early Career Achievement Award in Thoracic Oncology, American Thoracic Society|
|2017||Lung Cancer Discovery Award, American Lung Association|
|2015||Cyrus Scholar Award in Basic/Translational Research, Cyrus Family Foundation|
|2011||Research Scholar Award, American Cancer Society|
|2009||Lung Cancer Discovery Award, American Lung Association/LUNGevity Foundation|
|2008||Career Development Award, The University of Texas SPORE in Lung Cancer|
|2007||Bristol-Meyers Squibb Award in Clinical/Translational Research, The University of Texas MD Anderson Cancer Center|
- Caetano MS, Hassane M, Van HT, Bugarin E, Cumpian AM, McDowell CL, Cavazos CG, Zhang H, Deng S, Diao L, Wang J, Evans SE, Behrens C, Wistuba II, Fuqua SAW, Lin H, Stabile LP, Watowich SS, Kadara H, Moghaddam SJ. Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer. Nat Commun 9(1):4589, 2018. e-Pub 2018. PMID: 30389925.
- Bauer AK, Umer M, Richardson VL, Cumpian AM, Harder AQ, Khosravi N, Azzegagh Z, Hara NM, Ehre C, Mohebnasab M, Caetano MS, Merrick DT, van Bokhoven A, Wistuba II, Kadara H, Dickey BF, Velmurugan K, Mann PR, Lu X, Barón AE, Evans CM, Moghaddam SJ. Requirement for MUC5AC in KRAS-dependent lung carcinogenesis. JCI Insight 3(15), 2018. e-Pub 2018. PMID: 30089720.
- De la Garza MM, Cumpian AM, Daliri S, Castro-Pando S, Umer M, Gong L, Khosravi N, Caetano MS, Ramos-Castañeda M, Flores AG, Beltran EC, Tran HT, Tuvim MJ, Ostrin EJ, Dickey BF, Evans CM, Moghaddam SJ. COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1α mediated tumor angiogenesis and proliferation. Oncotarget 9(68):32972-32983, 2018. e-Pub 2018. PMID: 30250643.
- Khosravi N, Caetano MS, Cumpian AM, Unver N, De la Garza Ramos C, Noble O, Daliri S, Hernandez BJ, Gutierrez BA, Evans SE, Hanash S, Alekseev AM, Yang Y, Chang SH, Nurieva R, Kadara H, Chen J, Ostrin EJ, Moghaddam SJ. IL22 Promotes Kras-Mutant Lung Cancer by Induction of a Protumor Immune Response and Protection of Stemness Properties. Cancer Immunol Res 6(7):788-797, 2018. e-Pub 2018. PMID: 29764837.
- Unver N, Delgado O, Zeleke K, Cumpian A, Tang X, Caetano MS, Wang H, Katayama H, Yu H, Szabo E, Wistuba II, Moghaddam SJ, Hanash SM, Ostrin EJ. Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. Int J Cancer 142(7):1405-1417, 2018. e-Pub 2017. PMID: 29134640.
- Caetano MS, Zhang H, Cumpian AM, Gong L, Unver N, Ostrin EJ, Daliri S, Chang SH, Ochoa CE, Hanash S, Behrens C, Wistuba II, Sternberg C, Kadara H, Ferreira CG, Watowich SS, Moghaddam SJ. IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer. Cancer Res 76(11):3189-99, 2016. e-Pub 2016. PMID: 27197187.
- Gong L, da Silva Caetano M, Cumpian AM, Daliri S, Garza Flores A, Chang SH, Ochoa CE, Evans CM, Yu Z, Moghaddam SJ. Tumor Necrosis Factor Links Chronic Obstructive Pulmonary Disease and K-ras Mutant Lung Cancer Through Induction of an Immunosuppressive Pro-tumor Microenvironment. Oncoimmunology 5(10):e1229724, 2016. e-Pub 2016. PMID: 27853654.
- Chang SH, Mirabolfathinejad SG, Katta H, Cumpian AM, Gong L, Caetano MS, Moghaddam SJ, Dong C. T Helper 17 Cells Play a Critical Pathogenic Role in Lung Cancer. Proc Natl Acad Sci U S A 111(15):5664-9, 2014. e-Pub 2014. PMID: 24706787.
- Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b Is Required for Airway Defence. Nature 505(7483):412-6, 2014. e-Pub 2013. PMID: 24317696.
- Gong L, Cumpian AM, Caetano MS, Ochoa CE, De la Garza MM, Lapid DJ, Mirabolfathinejad SG, Dickey BF, Zhou Q, Moghaddam SJ. Promoting Effect of Neutrophils on Lung Tumorigenesis Is Mediated by CXCR2 and Neutrophil Elastase. Mol Cancer 12(1):154, 2013. e-Pub 2013. PMID: 24321240.
- Barta P, Van Pelt C, Men T, Dickey BF, Lotan R, Moghaddam SJ. Enhancement of Lung Tumorigenesis in a Gprc5a Knockout Mouse by Chronic Extrinsic Airway Inflammation. Mol Cancer 11(1):4, 2012. e-Pub 2012. PMID: 22239913.
- Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ. Interleukin 6 But Not T helper 2 Cytokines Promotes Lung Carcinogenesis. Cancer Prev Res (Phila) 4(1):51-64, 2011. e-Pub 2010. PMID: 21098042.
- Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin Inhibits COPD-Like Airway Inflammation and Lung Cancer Progression in Mice. Carcinogenesis. Carcinogenesis 30(11):1949-56, 2009. e-Pub 2009. PMID: 19793800.
- Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ. Promotion of Lung Carcinogenesis by COPD-Like Airway Inflammation in a K ras Induced Mouse Model. Am J Respir Cell Mol Biol 40(4):443-53 (Cover Art), 2009. e-Pub 2008. PMID: 18927348.
- Moghaddam SJ, Clement CG, De la Garza MM, Zou X, Travis EL, Young HW, Evans CM, Tuvim MJ, Dickey BF. Haemophilus influenzae Lysate Induces Aspects of the Chronic Obstructive Pulmonary Disease Phenotype. Am J Respir Cell Mol Biol 38(6):629-38 (Cover), 2008. e-Pub 2007. PMID: 18096867.
- Deng S, Ramos-Castaneda M, Velasco WV, Clowers MJ, Gutierrez BA, Noble O, Dong Y, Zarghooni M, Alvarado L, Caetano MS, Yang S, Ostrin EJ, Behrens C, Wistuba II, Stabile LP, Kadara H, Watowich SS, Moghaddam SJ. Interplay between Estrogen and Stat3/NF-κB Driven Immunomodulation in Lung Cancer. Carcinogenesis. e-Pub 2020. PMID: 32603404.
- Deng S, Clowers MJ, Velasco WV, Ramos-Castaneda M, Moghaddam SJ. Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment. Front Oncol 9:1556, 2019. e-Pub 2020. PMID: 32039025.
- Aghapour M, Raee P, Moghaddam SJ, Hiemstra PS, Heijink IH. Airway Epithelial Barrier Dysfunction in COPD: Role of Cigarette Smoke Exposure. Am J Respir Cell Mol Biol, 2017. e-Pub 2017. PMID: 28933915.
- Moghaddam SJ, Ochoa CE, Sethi S, Dickey BF. Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease and Lung Cancer. Int J Chron Obstruct Pulmon Dis 6:113-23, 2011. e-Pub 2011. PMID: 21407824.
- Sharafkhaneh A, Velamuri S, Moghaddam SJ, Badmaev V, Dickey B, Kurie J. Natural Agents for Chemoprevention of Lung Cancer. In: Lung Cancer. Chapter 28. Blackwell: Abingdon, UK, 2008.