Shao-Rui Chen, M.D.
Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology, Critical Care Medicine, and Pain Medicine
Education & Training
Degree-Granting Education
| 1982 | Qingdao Medical College, Shandong, CHN, MD, Clinical Medicine |
Experience & Service
Academic Appointments
Assistant Professor, Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology, Critical Care Medicine and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2013
Senior Research Associate, Department of Anesthesiology, Penn State University College of Medicine, Hershey, PA, 2004 - 2006
Research Associate, Department of Anesthesiology, Penn State University, Hershey, PA, 2000 - 2004
Research Assistant, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC, 1996 - 2000
Research Assistant, Department of Internal Medicine, Division of Internal Medicine, University of Human Physiology and Internal Medicine, Davis, CA, 1992 - 2000
Resident and Attending Physician, Department of Pediatrics Patient Care, Division of Pediatrics, Xintai People's Hospital, Shandong, 1982 - 1992
Selected Publications
Peer-Reviewed Articles
- Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL.. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol 86(6):760-72, 2014. e-Pub 2014. PMID: 25267719.
- Chen SR, Zhu L, Chen H, Wen L, Laumet G, Pan HL.. Increased Spinal Cord Na+-K+-2Cl- Cotransporter-1 (NKCC1) Activity Contributes to Impairment of Synaptic Inhibition in Paclitaxel-induced Neuropathic Pain. J Biol Chem 289(45):31111-20, 2014. e-Pub 2014. PMID: 25253692.
- Pachuau J, Li DP, Chen SR, Lee HA, Pan HL.. Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. J Neurochem 130(5):657-67, 2014. e-Pub 2014. PMID: 24806793.
- Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET.. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron 83(5), 2014. PMID: 25189211.
- Chen SR, Zhou HY, Byun HS, Chen H, Pan HL.. Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury. J Pharmacol Exp Ther 350(2):301-12, 2014. e-Pub 2014. PMID: 24898266.
- Hu YM, Chen SR, Chen H, Pan HL.. Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. J Pharmacol Exp Ther 349(2):239-47, 2014. e-Pub 2014. PMID: 24610957.
- Chen SR, Chen H, Yuan WX, Wess J, Pan HL.. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem 289(20):14321-30, 2014. e-Pub 2014. PMID: 24695732.
- Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L.. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci 17(2):232-9, 2014. e-Pub 2014. PMID: 24390226.
- Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. J Biol Chem 286(38):33190-202, 2011. e-Pub 2011. PMID: 21813646.
- Chen SR, Chen H, Yuan WX, Pan HL. Increased Pre- and Postsynaptic {alpha}2-Adrenoceptor Activity in the Spinal Dorsal Horn in Painful Diabetic Neuropathy. J Pharmacol Exp Ther 337(1):285-92, 2011. e-Pub 2011. PMID: 21248068.
- Zhou HY, Chen SR, Chen H, Pan HL. Functional plasticity of group II metabotropic glutamate receptors in regulating spinal excitatory and inhibitory synaptic input in neuropathic pain. J Pharmacol Exp Ther 336(1):254-64, 2011. e-Pub 2010. PMID: 20923868.
Invited Articles
- Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol 4:379-388, 2011. PMID: 21686074.
Book Chapters
- Bavencoffe A, Chen SR, Pan HL.. Regulation of nociceptive transduction and transmission by nitric oxide. In: Vitam Horm - Nitric Oxide. 96. Elsevier Inc., Academic Press, 1-18, 2014.