Shao-Rui Chen, M.D.
Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology, Critical Care, and Pain Medicine
Education & Training
Degree-Granting Education
| 1982 | Qingdao Medical College, Shandong, CHN, MD, Clinical Medicine |
Experience & Service
Academic Appointments
Assistant Professor, Department of Anesthesiology and Perioperative Medicine, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2013
Senior Research Associate, Department of Anesthesiology, Penn State University College of Medicine, Hershey, PA, 2004 - 2006
Research Associate, Department of Anesthesiology, Penn State University, Hershey, PA, 2000 - 2004
Research Assistant, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC, 1996 - 2000
Research Assistant, Department of Internal Medicine, Division of Internal Medicine, University of Human Physiology and Internal Medicine, Davis, CA, 1992 - 2000
Resident and Attending Physician, Department of Pediatrics Patient Care, Division of Pediatrics, Xintai People's Hospital, Shandong, 1982 - 1992
Selected Publications
Peer-Reviewed Articles
- Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL.. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol 86(6):760-72, 2014. e-Pub 2014. PMID: 25267719.
- Chen SR, Zhu L, Chen H, Wen L, Laumet G, Pan HL.. Increased Spinal Cord Na+-K+-2Cl- Cotransporter-1 (NKCC1) Activity Contributes to Impairment of Synaptic Inhibition in Paclitaxel-induced Neuropathic Pain. J Biol Chem 289(45):31111-20, 2014. e-Pub 2014. PMID: 25253692.
- Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET.. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron 83(5), 2014. PMID: 25189211.
- Pachuau J, Li DP, Chen SR, Lee HA, Pan HL.. Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. J Neurochem 130(5):657-67, 2014. e-Pub 2014. PMID: 24806793.
- Chen SR, Zhou HY, Byun HS, Chen H, Pan HL.. Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury. J Pharmacol Exp Ther 350(2):301-12, 2014. e-Pub 2014. PMID: 24898266.
- Chen SR, Chen H, Yuan WX, Wess J, Pan HL.. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem 289(20):14321-30, 2014. e-Pub 2014. PMID: 24695732.
- Hu YM, Chen SR, Chen H, Pan HL.. Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. J Pharmacol Exp Ther 349(2):239-47, 2014. e-Pub 2014. PMID: 24610957.
- Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L.. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci 17(2):232-9, 2014. e-Pub 2014. PMID: 24390226.
- Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. J Biol Chem 286(38):33190-202, 2011. e-Pub 2011. PMID: 21813646.
- Chen SR, Chen H, Yuan WX, Pan HL. Increased Pre- and Postsynaptic {alpha}2-Adrenoceptor Activity in the Spinal Dorsal Horn in Painful Diabetic Neuropathy. J Pharmacol Exp Ther 337(1):285-92, 2011. e-Pub 2011. PMID: 21248068.
- Zhou HY, Chen SR, Chen H, Pan HL. Functional plasticity of group II metabotropic glutamate receptors in regulating spinal excitatory and inhibitory synaptic input in neuropathic pain. J Pharmacol Exp Ther 336(1):254-64, 2011. e-Pub 2010. PMID: 20923868.
Invited Articles
- Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol 4:379-388, 2011. PMID: 21686074.
Book Chapters
- Bavencoffe A, Chen SR, Pan HL.. Regulation of nociceptive transduction and transmission by nitric oxide. In: Vitam Horm - Nitric Oxide. 96. Elsevier Inc., Academic Press, 1-18, 2014.