Shao-Rui Chen, M.D.

Peer-Reviewed Articles

1. Zhou, J, Shao, JY, Chen, S, Li, DP, Pan, H. Potentiated angiotensin AT1 receptor activity is associated with age-dependent expansion of adrenal-projecting presympathetic circuitry in hypertension. Neurobiology of Disease 229, 2026. e-Pub 2026. PMID: 42722113.
2. Jin, D, Chen, H, Huang, Y, Chen, S, Pan, H. BRAF recruitment to spinal sensory synapses promotes neuropathic pain by potentiating transsynaptic NMDA receptor activity. Science Signaling 19(952), 2026. e-Pub 2026. PMID: 42640998.
3. Jin, D, Chen, H, Huang, Y, Chen, S, Pan, H. Sensory Neuron BRAF Mediates Opioid-Induced Hyperalgesia and Tolerance via Presynaptic NMDA Receptor Hyperactivity. Journal of Clinical Investigation:1-42, 2026. e-Pub 2026. PMID: 42446936.
4. Gautam, V, Huang, Y, Chen, H, Chen, S, Pan, H. HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1–Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses. Journal of Neuroscience 46(25):1-15, 2026. e-Pub 2026. PMID: 42225412.
5. Liu, N, Shi, X, Chen, S, Chen, H, Santi, MD, Phuong, DM, Fialho, MP, Xie, T, Gleber-Netto, FO, Latorre, R, Bunnett, NW, Viet, CT, Amit, M, Pan, H, Ye, Y. EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer. Science Signaling 19(922):eadt3026, 2026. e-Pub 2026. PMID: 41592151.
6. Wei, S, Xu, J, Chen, S, Huang, Y, Jarrett, Z, Godlewski, G, Paloczi, J, Pacher, P, Pan, H, Xu, Y, Lovinger, DM, Zhang, L. Spinal glycine receptor alpha 1 coordinates startle behavior through a cell-type specific mechanism. International journal of biological sciences 22(12):6631-6652, 2026. e-Pub 2026. PMID: 42524505.
7. Yuying Huang, Hong Cheng, Chen S, Hui-Lin Pan. Tonic GABA and Glycine Inhibition Control Pain Hypersensitivity via Limiting α2δ-1- and mGluR5-Dependent NMDA Receptor Activity at Primary Afferent→Excitatory Neuron Synapses. Journal of Neuroscience 45(44), 2025. e-Pub 2025. PMID: 41006062.
8. Meng-Hua Zhou, Chen S, Daozhong Jin, Yuying Huang, Hong Chen, Guanxing Chen, Jiusheng Yan, Hui-Lin Pan. Spinal α2δ-1 induces GluA3 degradation to regulate assembly of calcium-permeable AMPA receptors and pain hypersensitivity. J Clin Invest 136(1), 2025. e-Pub 2025. PMID: 41129242.
9. Meichun Deng, Shao-Rui Chen, Meng-Hua Zhou, Jixiang Zhang, Yuying Huang, Hong Chen, Fernando Benavides, Rajan Sah, Hui-Lin Pan. LRRC8A constitutively inhibits pain hypersensitivity in rodent models by restraining NMDA receptor activity at spinal cord synapses. Science translational medicine 17(821), 2025. e-Pub 2025. PMID: 41124282.
10. Daozhong Jin, Hong Chen, Meng-Hua Zhou, Yuying Huang, Shao-Rui Chen, Hui-Lin Pan. Gαq signaling in primary sensory neurons shifts opioid analgesia to NMDA receptor-driven tolerance and hyperalgesia. Science Signaling 18(902), 2025. e-Pub 2025. PMID: 40892896.
11. Zhou JJ, Shao JY, Chen S, Ye ZY, Pan HL. RCAN1-Mediated Calcineurin Impairment Drives Sympathetic Outflow in Hypertension. Circulation research 137(3):417-434, 2025. e-Pub 2025. PMID: 40510021.
12. Zhou, M, Zhou, J, Chen, S, Chen, H, Jin, D, Huang, Y, Shao, JY, Pan, H. α2δ-2 regulates synaptic GluK1 kainate receptors in Purkinje cells and motor coordination. Brain 148(4):1271-1285, 2025. e-Pub 2025. PMID: 39439207.
13. Ghosh, K, Huang, Y, Jin, D, Chen, S, Pan, H. Histone Methyltransferase G9a in Primary Sensory Neurons Promotes Inflammatory Pain and Transcription of Trpa1 and Trpv1 via Bivalent Histone Modifications. Journal of Neuroscience 45(6), 2025. e-Pub 2025. PMID: 39824634.
14. Ghosh, K, Huang, Y, Chen, S, Pan, H. Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone deacetylase HDAC2 in dorsal root ganglia. Journal of Biological Chemistry 300(11), 2024. e-Pub 2024. PMID: 39357831.
15. Huang, Y, Chen, S, Shao, JY, Pan, H, Zhou, J, Chen, H. Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons. Journal of Neuroscience 44(29), 2024. e-Pub 2024. PMID: 38886057.
16. Carrillo E, Romero Montano A, Gonzalez C, Turcu A, Chen S, Chen H, Pan HL, Vazquez S, Twomey E, Jayaraman V. Memantine inhibits calcium permeable AMPA receptors. bioRxiv. e-Pub 2024. PMID: 39005433.
17. Zhou, J, Shao, JY, Chen, S, Chen, H, Pan, H. Calcineurin regulates synaptic Ca2+-permeable AMPA receptors in hypothalamic presympathetic neurons via α2δ-1-mediated GluA1/GluA2 assembly. Journal of Physiology 602(10):2179-2197, 2024. e-Pub 2024. PMID: 38630836.
18. Ghosh, K, Zhou, J, Shao, JY, Chen, S, Pan, H. DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development. Journal of Biological Chemistry 300(2), 2024. e-Pub 2024. PMID: 38160798.
19. Huang, Y, Chen, S, Pan, H, Chen, H, Shao, JY, Zhou, J. Constitutive KCC2 Cell- and Synapse-Specifically Regulates NMDA Receptor Activity in the Spinal Cord. Journal of Neuroscience, 2024. e-Pub 2024. PMID: 38124193.
20. Zhou, J, Shao, JY, Chen, S, Pan, H. Brain α2δ-1-Bound NMDA Receptors Drive Calcineurin Inhibitor-Induced Hypertension. Circulation research 133(7):611-627, 2023. e-Pub 2023. PMID: 37605933.
21. Jin, D, Chen, H, Zhou, M, Chen, S, Pan, H. mGluR5 from Primary Sensory Neurons Promotes Opioid-Induced Hyperalgesia and Tolerance by Interacting with and Potentiating Synaptic NMDA Receptors. Journal of Neuroscience 43(31):5593-5607, 2023. e-Pub 2023. PMID: 37451981.
22. Huang, Y, Chen, H, Jin, D, Chen, S, Pan, H. NMDA Receptors at Primary Afferent–Excitatory Neuron Synapses Differentially Sustain Chemotherapy- and Nerve Trauma-Induced Chronic Pain. Journal of Neuroscience 43(21):3933-3948, 2023. e-Pub 2023. PMID: 37185237.
23. Huang, Y, Chen, H, Chen, S, Pan, H. Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors. ACS Chemical Neuroscience 14(7):1261-1277, 2023. e-Pub 2023. PMID: 36930958.
24. Jin, D, Chen, H, Chen, S, Pan, H. α2δ-1 protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry 164(2):143-157, 2023. e-Pub 2023. PMID: 36222452.
25. Chen, S, Chen, H, Jin, D, Pan, H. Brief Opioid Exposure Paradoxically Augments Primary Afferent Input to Spinal Excitatory Neurons via α2δ-1–Dependent Presynaptic NMDA Receptors. Journal of Neuroscience 42(50):9315-9329, 2022. e-Pub 2022. PMID: 36379705.
26. Zhang, J, Chen, S, Zhou, M, Jin, D, Chen, H, Wang, L, DePinho, RA, Pan, H. HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity. Journal of Neuroscience 42(48):8918-8935, 2022. e-Pub 2022. PMID: 36257688.
27. Jin, D, Chen, H, Huang, Y, Chen, S, Pan, H. δ-Opioid receptors in primary sensory neurons tonically restrain nociceptive input in chronic pain but do not enhance morphine analgesic tolerance. Neuropharmacology 217, 2022. e-Pub 2022. PMID: 35917874.
28. Zhou, J, Shao, JY, Chen, S, Pan, H. Calcineurin Controls Hypothalamic NMDA Receptor Activity and Sympathetic Outflow. Circulation research 131(4):345-360, 2022. e-Pub 2022. PMID: 35862168.
29. Ghosh, K, Zhang, G, Chen, H, Chen, S, Pan, H. Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain. Journal of Biological Chemistry 298(6), 2022. e-Pub 2022. PMID: 35500651.
30. Zhou, J, Shao, JY, Chen, S, Chen, H, Pan, H. α2δ-1 protein promotes synaptic expression of Ca2+ permeable–AMPA receptors by inhibiting GluA1/GluA2 heteromeric assembly in the hypothalamus in hypertension. Journal of neurochemistry 161(1):40-52, 2022. e-Pub 2022. PMID: 35038178.
31. Huang, Y, Chen, S, Chen, H, Zhou, J, Jin, D, Pan, H. Theta-Burst Stimulation of Primary Afferents Drives LongTerm Potentiation in the Spinal Cord and Persistent Pain via α2δ-1-Bound NMDA Receptors. Journal of Neuroscience 42(3):513-527, 2022. e-Pub 2022. PMID: 34880118.
32. Zhou, M, Chen, S, Wang, L, Huang, Y, Deng, M, Zhang, J, Zhang, J, Chen, H, Yan, J, Pan, H. Protein kinase C-mediated phosphorylation and α2δ-1 interdependently regulate NMDA receptor trafficking and activity. Journal of Neuroscience 41(30):6415-6429, 2021. e-Pub 2021. PMID: 34252035.
33. Zhou, J, Shao, JY, Chen, S, Li, DP, Pan, H. α2δ-1–dependent NMDA receptor activity in the hypothalamus is an effector of genetic-environment interactions that drive persistent hypertension. Journal of Neuroscience 41(30):6551-6563, 2021. e-Pub 2021. PMID: 34193557.
34. Li, L, Chen, S, Zhou, M, Wang, L, Li, DP, Chen, H, Lee, G, Jayaraman, V, Pan, H. α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. Cell Reports 36(3), 2021. e-Pub 2021. PMID: 34289359.
35. Zhang, G, Chen, S, Jin, D, Huang, Y, Chen, H, Pan, H. α2δ-1 upregulation in primary sensory neurons promotes NMDA receptor-mediated glutamatergic input in resiniferatoxin-induced neuropathy. Journal of Neuroscience 41(27):5963-5978, 2021. e-Pub 2021. PMID: 34252037.
36. Zhou, J, Luo, Y, Chen, S, Shao, JY, Sah, R, Pan, H. LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons. Experimental Neurology 332, 2020. e-Pub 2020. PMID: 32598930.
37. Zhou, J, Pachuau, J, Li, DP, Chen, S, Pan, H. Group III metabotropic glutamate receptors regulate hypothalamic presympathetic neurons through opposing presynaptic and postsynaptic actions in hypertension. Neuropharmacology 174, 2020. e-Pub 2020. PMID: 32454125.
38. Huang, Y, Chen, S, Chen, H, Luo, Y, Pan, H. Calcineurin inhibition causes A2D-1–mediated tonic activation of synaptic NMDA receptors and pain hypersensitivity. Journal of Neuroscience 40(19):3707-3719, 2020. e-Pub 2020. PMID: 32269108.
39. Luo, Y, Zhang, J, Chen, L, Chen, S, Chen, H, Zhang, G, Pan, H. Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain. Journal of Biological Chemistry 295(11):3553-3562, 2020. e-Pub 2020. PMID: 32024693.
40. Sun, J, Chen, S, Pan, H. μ-Opioid receptors in primary sensory neurons are involved in supraspinal opioid analgesia. Brain Research 1729, 2020. e-Pub 2020. PMID: 31881186.
41. Huang, Y, Chen, S, Chen, H, Pan, H. Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. Journal of neurochemistry 149(3):381-398, 2019. e-Pub 2019. PMID: 30716174.
42. Deng, M, Chen, S, Chen, H, Pan, H. α2δ-1-Bound N-Methyl-d-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents. Anesthesiology 130(5):804-819, 2019. e-Pub 2019. PMID: 30839350.
43. Sun J, Chen SR, Chen H, Pan HL. μ-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia. J Physiol 597(6):1661-1675, 2019. e-Pub 2019. PMID: 30578671.
44. Chen, S, Zhang, J, Chen, H, Pan, H. Streptozotocin-induced diabetic neuropathic pain is associated with potentiated calcium-permeable AMPA receptor activity in the spinal cord. Journal of Pharmacology and Experimental Therapeutics 371(2):242-249, 2019. e-Pub 2019. PMID: 31481518.
45. Ma, HJ, Chen, S, Chen, H, Pan, H. Endogenous AT1 receptor–protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension. Journal of Physiology 597(16):4325-4340, 2019. e-Pub 2019. PMID: 31241170.
46. Chen Y, Chen SR, Chen H, Zhang J, Pan HL. Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain. J Neurochem 148(2):252-274, 2019. e-Pub 2019. PMID: 30431158.
47. Deng M, Chen SR, Chen H, Luo Y, Dong Y, Pan HL. Mitogen-activated protein kinase signaling mediates opioid-induced presynaptic NMDA receptor activation and analgesic tolerance. J Neurochem 148(2):275-290, 2019. e-Pub 2019. PMID: 30444263.
48. Zhou JJ, Li DP, Chen SR, Luo Y, Pan HL. The α2δ-1-NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory. J Biol Chem 293(50):19354-19364, 2018. e-Pub 2018. PMID: 30355732.
49. Zhang J, Chen SR, Chen H, Pan HL. RE1-silencing transcription factor controls the acute-to-chronic neuropathic pain transition and Chrm2 receptor gene expression in primary sensory neurons. J Biol Chem 293(49):19078-19091, 2018. e-Pub 2018. PMID: 30327427.
50. Wang L, Chen SR, Ma H, Chen H, Hittelman WN, Pan HL. Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons. J Neurochem 147(4):526-540, 2018. e-Pub 2018. PMID: 30203849.
51. Luo Y, Ma H, Zhou JJ, Li L, Chen SR, Zhang J, Chen L, Pan HL. Focal Cerebral Ischemia and Reperfusion Induce Brain Injury Through α2δ-1-Bound NMDA Receptors. Stroke 49(10):2464-2472, 2018. e-Pub 2018. PMID: 30355118.
52. Ma H, Chen SR, Chen H, Zhou JJ, Li DP, Pan HL. α2δ-1 couples to NMDA receptors in the hypothalamus to sustain sympathetic vasomotor activity in hypertension. J Physiol 596(17):4269-4283, 2018. e-Pub 2018. PMID: 29971791.
53. Ma H, Chen SR, Chen H, Li L, Li DP, Zhou JJ, Pan HL. α2δ-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus. J Neurosci 38(28):6388-6398, 2018. e-Pub 2018. PMID: 29921713.
54. Garriga J, Laumet G, Chen SR, Zhang Y, Madzo J, Issa JJ, Pan HL, Jelinek J. Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion. J Neurosci 38(27):6090-6101, 2018. e-Pub 2018. PMID: 29875269.
55. Zhang X, Chen S, Chen H, Pan H, Zhao Y. Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors. Mol Neurobiol 55(6):5393-5407, 2018. e-Pub 2018. PMID: 28975565.
56. Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep 22(9):2307-2321, 2018. e-Pub 2018. PMID: 29490268.
57. Xie JD, Chen SR, Pan HL. Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C-NMDA receptors in paclitaxel-induced neuropathic pain. J Biol Chem 292(50):20644-20654, 2017. e-Pub 2017. PMID: 29074619.
58. Chen SR, Jin XG, Pan HL. Endogenous nitric oxide inhibits spinal NMDA receptor activity and pain hypersensitivity induced by nerve injury. Neuropharmacology 125:156-165, 2017. e-Pub 2017. PMID: 28754372.
59. Xie JD, Chen SR, Chen H, Pan HL. Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord. Neuropharmacology 123:477-487, 2017. e-Pub 2017. PMID: 28663117.
60. Chen SR, Chen H, Zhou JJ, Pradhan G, Sun Y, Pan HL, Li DP. Ghrelin Receptors Mediate Ghrelin-Induced Excitation of AgRP/NPY But Not POMC Neurons. J Neurochem 142(4):512-520, 2017. e-Pub 2017. PMID: 28547758.
61. Xie JD, Chen SR, Chen H, Zeng WA, Pan HL. Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain. J Biol Chem 291(37):19364-73, 2016. e-Pub 2016. PMID: 27458019.
62. Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL. Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Rep 15(7):1376-83, 2016. e-Pub 2016. PMID: 27160909.
63. Zhang Y, Chen SR, Laumet G, Chen H, Pan HL. Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons. J Biol Chem 291(16):8475-85, 2016. e-Pub 2016. PMID: 26917724.
64. Zhu Y, Chen SR, Pan HL. Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. J Neurochem 137(2):226-39, 2016. e-Pub 2016. PMID: 26823384.
65. Laumet, GO, Garriga, J, Chen, S, Zhang, Y, Li, DP, Smith, TM, Dong, Y, Jelinek, J, Cesaroni, M, Issa, JP, Pan, H. G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition. Nature Neuroscience 18(12):1746-1755, 2015. e-Pub 2015. PMID: 26551542.
66. Zhang Y, Laumet G, Chen SR, Hittelman WN, Pan HL. Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development. J Biol Chem 290(23):14647-55, 2015. e-Pub 2015. PMID: 25925949.
67. Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol 86(6):760-72, 2014. e-Pub 2014. PMID: 25267719.
68. Chen SR, Zhu L, Chen H, Wen L, Laumet G, Pan HL. Increased Spinal Cord Na+-K+-2Cl- Cotransporter-1 (NKCC1) Activity Contributes to Impairment of Synaptic Inhibition in Paclitaxel-induced Neuropathic Pain. J Biol Chem 289(45):31111-20, 2014. e-Pub 2014. PMID: 25253692.
69. Pachuau J, Li DP, Chen SR, Lee HA, Pan HL. Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. J Neurochem 130(5):657-67, 2014. e-Pub 2014. PMID: 24806793.
70. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron 83(5), 2014. e-Pub 2014. PMID: 25189211.
71. Chen SR, Zhou HY, Byun HS, Chen H, Pan HL. Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury. J Pharmacol Exp Ther 350(2):301-12, 2014. e-Pub 2014. PMID: 24898266.
72. Li DP, Chen S. Nitric oxide stimulates glutamatergic synaptic inputs to baroreceptor neurons through potentiation of Cav2.2-mediated Ca(2+) currents. Neurosci Lett 1(567):57-62, 2014. e-Pub 2014. PMID: 24686191.
73. Hu YM, Chen SR, Chen H, Pan HL. Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. J Pharmacol Exp Ther 349(2):239-47, 2014. e-Pub 2014. PMID: 24610957.
74. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem 289(20):14321-30, 2014. e-Pub 2014. PMID: 24695732.
75. Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci 17(2):232-9, 2014. e-Pub 2014. PMID: 24390226.
76. Chen SR, Hu YM, Chen H, Pan HL. Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. J Physiol 592(1):215-227, 2014. e-Pub 2014. PMID: 24081160.
77. Chen SR, Zhou HY, Byun HS, Pan HL. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. J Pharmacol Exp Ther 347(3):765-772, 2013. e-Pub 2013. PMID: 24030012.
78. Petrov RR, Knight L, Chen SR, Wager-Miller J, McDaniel SW, Diaz F, Barth F, Pan HL, Mackie K, Cavasotto CN, Diaz P. Mastering tricyclic ring systems for desirable functional cannabinoid activity. Eur J Med Chem 69(881-907), 2013. e-Pub 2013. PMID: 24125850.
79. Zeng SY, Chen X, Chen SR, Li Q, Wang YH, Zou J, Cao WW, Luo JN, Gao H, Liu PQ. Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression. Can J Cardiol 29(10):1310-1319, 2013. e-Pub 2013. PMID: 23850346.
80. Guo YX, Li DP, Chen SR, Pan HL. Distinct intrinsic and synaptic properties of pre-sympathetic and pre-parasympathetic output neurons in Barrington's nucleus. J Neurochem 126(3):338-348, 2013. e-Pub 2013. PMID: 23647148.
81. Cai YQ, Chen SR, Pan HL. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther 345(1):161-168, 2013. e-Pub 2013. PMID: 23386250.
82. Zhou HY, Chen SR, Byun HS, Chen H, Li L, Han HD, Lopez-Berestein G, Sood AK, Pan HL. NMDA Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl- Cotransporter-2 Disrupts Spinal Chloride Homeostasis in Neuropathic Pain. J Biol Chem 287(40):33853-64, 2012. e-Pub 2012. PMID: 22854961.
83. Zhao YL, Chen SR, Chen H, Pan HL. Chronic Opioid Potentiates Presynaptic but Impairs Postsynaptic N-Methyl-D-aspartic Acid Receptor Activity in Spinal Cords: IMPLICATIONS FOR OPIOID HYPERALGESIA AND TOLERANCE. J Biol Chem 287(30):25073-85, 2012. e-Pub 2012. PMID: 22679016.
84. Xiong W, Cui T, Cheng K, Yang F, Chen SR, Willenbring D, Guan Y, Pan HL, Ren K, Xu Y, Zhang L. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med 209(6):1121-34, 2012. e-Pub 2012. PMID: 22585736.
85. Cao XH, Chen SR, Li L, Pan HL. Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons. J Neurochem 121(6):944-53, 2012. e-Pub 2012. PMID: 22428625.
86. Li L, Cao XH, Chen SR, Han HD, Lopez-Berestein G, Sood AK, Pan HL. Up-regulation of Cavβ3 Subunit in Primary Sensory Neurons Increases Voltage-activated Ca2+ Channel Activity and Nociceptive Input in Neuropathic Pain. J Biol Chem 287(8):6002-13, 2012. e-Pub 2012. PMID: 22187436.
87. Cao XH, Byun HS, Chen SR, Pan HL. Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons. J Neurochem 119(3):594-603, 2011. e-Pub 2011. PMID: 21883220.
88. Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. J Biol Chem 286(38):33190-202, 2011. e-Pub 2011. PMID: 21813646.
89. Chen SR, Chen H, Yuan WX, Pan HL. Increased Pre- and Postsynaptic {alpha}2-Adrenoceptor Activity in the Spinal Dorsal Horn in Painful Diabetic Neuropathy. J Pharmacol Exp Ther 337(1):285-92, 2011. e-Pub 2011. PMID: 21248068.
90. Zhou HY, Chen SR, Chen H, Pan HL. Functional plasticity of group II metabotropic glutamate receptors in regulating spinal excitatory and inhibitory synaptic input in neuropathic pain. J Pharmacol Exp Ther 336(1):254-64, 2011. e-Pub 2011. PMID: 20923868.
91. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. J Biol Chem 285(52):40427-37, 2010. e-Pub 2010. PMID: 20940295.
92. Cao XH, Byun HS, Chen SR, Cai YQ, Pan HL. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. J Neurochem 114(5):1460-75, 2010. e-Pub 2010. PMID: 20557422.
93. Li DP, Chen SR, Pan HL. Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. J Neurochem 113(2):530-42, 2010. e-Pub 2010. PMID: 20096091.
94. Zhou HY, Chen SR, Chen H, Pan HL. Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci 30(12):4460-6, 2010. e-Pub 2010. PMID: 20335482.
95. Li JQ, Chen SR, Chen H, Cai YQ, Pan HL. Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J Neurochem 112(1):162-72, 2010. e-Pub 2010. PMID: 19840219.
96. Wu ZZ, Li DP, Chen SR, Pan HL. Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit. J Biol Chem 284(52):36453-61, 2009. e-Pub 2009. PMID: 19850918.
97. Sun H, Li DP, Chen SR, Hittelman WN, Pan HL. Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors. J Pharmacol Exp Ther 331(3):851-9, 2009. e-Pub 2009. PMID: 19726694.
98. Cai YQ, Chen SR, Han HD, Sood AK, Lopez-Berestein G, Pan HL. Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. J Neurochem 111(4):1000-10, 2009. e-Pub 2009. PMID: 19780895.
99. Chen SR, Samoriski G, Pan HL. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology 57(2):121-6, 2009. e-Pub 2009. PMID: 19422840.
100. Chen SR, Cai YQ, Pan HL. Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain. J Neurochem 110(1):352-62, 2009. e-Pub 2009. PMID: 19457113.
101. Yuan WX, Chen SR, Chen H, Pan HL. Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience 158(4):1616-24, 2009. e-Pub 2009. PMID: 19068225.
102. Zhang HM, Chen SR, Cai YQ, Richardson TE, Driver LC, Lopez-Berestein G, Pan HL. Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord. Neuroscience 158(4):1577-88, 2009. e-Pub 2009. PMID: 19110040.
103. Zhang HM, Chen SR, Pan HL. Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience 158(2):875-84, 2009. e-Pub 2009. PMID: 19017536.
104. Zhou HY, Chen SR, Chen H, Pan HL. The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. J Neurochem 108(1):305-18, 2009. e-Pub 2009. PMID: 19012737.
105. Zhou HY, Chen SR, Chen H, Pan HL. Sustained Inhibition of Neurotransmitter Release from non-TRPV1-Expressing Primary Afferents by [D-Ala2,N-Me-Phe4,Gly-ol5]-Enkephalin in the Spinal Cord. J Pharmacol Exp Ther 327(2):375-82, 2008. e-Pub 2008. PMID: 18669865.
106. Chen SR, Pan HL. Removing TRPV1-expressing primary afferent neurons potentiates the spinal analgesic effect of delta-opioid agonists on mechano-nociception. Neuropharmacology 55(2):215-222, 2008. e-Pub 2008. PMID: 18579164.
107. Wu ZZ, Chen SR, Pan HL. Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents. Neuroscience 153(4):1256-67, 2008. e-Pub 2008. PMID: 18434033.
108. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. J Pharmacol Exp Ther 324(3):1000-10, 2008. e-Pub 2008. PMID: 18079355.
109. Zhang HM, Zhou HY, Chen SR, Gautam D, Wess J, Pan HL. Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice. J Pharmacol Exp Ther 323(3):963-71, 2007. e-Pub 2007. PMID: 17878406.
110. Yang Q, Chen SR, Li DP, Pan HL. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Neuroscience 149(2):315-27, 2007. e-Pub 2007. PMID: 17869444.
111. Chen SR, Pan HM, Richardson TE, Pan HL. Potentiation of spinal alpha(2)-adrenoceptor analgesia in rats deficient in TRPV1-expressing afferent neurons. Neuropharmacology 52(8):1624-30, 2007. e-Pub 2007. PMID: 17482651.
112. Chen SR, Prunean A, Pan HM, Welker KL, Pan HL. Resistance to morphine analgesic tolerance in rats with deleted transient receptor potential vanilloid type 1-expressing sensory neurons. Neuroscience 145(2):676-85, 2007. e-Pub 2007. PMID: 17239544.
113. Wang XL, Zhang HM, Chen SR, Pan HL. Altered synaptic input and GABAB receptor function in spinal superficial dorsal horn neurons inrats with diabetic neuropathy. J Physiol 579(Pt 3):849-61, 2007. e-Pub 2007. PMID: 17218355.
114. Zhang HM, Chen SR, Pan HL. Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. J Neurophysiol 97(1):102-9, 2007. e-Pub 2007. PMID: 17050831.
115. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate. J Neurophysiol 91(1):871-882, 2007. e-Pub 2007. PMID: 17108089.
116. Wu ZZ, Chen SR, Pan HL. Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. Neuroscience 141(1):407-19, 2006. e-Pub 2006. PMID: 16678970.
117. Chen SR, Pan HL. Loss of TRPV1-expressing sensory neurons reduces spinal mu opioid receptors but paradoxically potentiates opioid analgesia. J Neurophysiol 95(5):3086-96, 2006. e-Pub 2006. PMID: 16467418.
118. Chen SR, Pan HL. Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids. Brain Res 1081(1):119-25, 2006. e-Pub 2006. PMID: 16499888.
119. Finnegan TF, Chen SR, Pan HL. Mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/1.2 channels. J Neurophysiol 95(4):2032-41, 2006. e-Pub 2006. PMID: 16306173.
120. Wang XL, Zhang HM, Li DP, Chen SR, Pan HL. Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats. J Physiol 571(Pt 2):403-13, 2006. e-Pub 2006. PMID: 16410279.
121. Zhang HM, Chen SR, Matsui M, Gautam D, Wess J, Pan HL. Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Mol Pharmacol 69(3):1048-55, 2006. e-Pub 2006. PMID: 16365281.
122. Chen YP, Chen SR, Pan HL. Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. J Pharmacol Exp Ther 315(2):696-703, 2005. e-Pub 2005. PMID: 16033910.
123. Chen YP, Chen SR, Pan HL. Systemic morphine inhibits dorsal horn projection neurons through spinal cholinergic system independent of descending pathways. J Pharmacol Exp Ther 314(2):611-617, 2005. e-Pub 2005. PMID: 15845859.
124. Vydyanathan A, Wu ZZ, Chen SR, Pan HL. A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons. J Neurophysiol 93(6):3401-9, 2005. e-Pub 2005. PMID: 15647393.
125. Wu ZZ, Chen SR, Pan HL. Transient receptor potential vanilloid type 1 activation down-regulates voltage-gated calcium channels through calcium-dependent calcineurin in sensory neurons. J Biol Chem 280(18):18142-51, 2005. e-Pub 2005. PMID: 15746091.
126. Chen SR, Wess J, Pan HL. Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice. J Pharmacol Exp Ther 313(2):765-70, 2005. e-Pub 2005. PMID: 15665136.
127. Zhang HM, Li DP, Chen SR, Pan HL. M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. J Pharmacol Exp Ther 313(2):697-704, 2005. e-Pub 2005. PMID: 15640398.
128. Chen SR, Pan HL. Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Res 1042(1):108-113, 2005. e-Pub 2005. PMID: 15823259.
129. Finnegan TF, Chen SR, Pan HL. Effect of the {mu} opioid on excitatory and inhibitory synaptic inputs to periaqueductal gray-projecting neurons in the amygdala. J Pharmacol Exp Ther 312(2):441-8, 2005. e-Pub 2005. PMID: 15388784.
130. Chen SR, Pan HL. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther 312(1):120-6, 2005. e-Pub 2005. PMID: 15375175.
131. Li DP, Atnip LM, Chen SR, Pan HL. Regulation of synaptic inputs to paraventricular-spinal output neurons by alpha2 adrenergic receptors. J Neurophysiol 93(1):393-402, 2005. e-Pub 2005. PMID: 15356178.
132. Wu ZZ, Chen SR, Pan HL. Differential sensitivity of N- and P/Q-type Ca2+ channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neurons. J Pharmacol Exp Ther 311(3):939-47, 2004. e-Pub 2004. PMID: 15280436.
133. Pan HL, Chen SR. Sensing tissue ischemia - another new function for capsaicin receptors?. Circulation 110(13):1832-1837, 2004. e-Pub 2004. PMID: 15364816.
134. Li DP, Chen SR, Pan HL. VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus. J Neurophysiol 92(3):1807-1816, 2004. e-Pub 2004. PMID: 15115794.
135. Finnegan TF, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons. J Pharmacol Exp Ther 309(2):476-83, 2004. e-Pub 2004. PMID: 14724227.
136. Pan YZ, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors excites a population of locus coeruleus-spinal neurons through presynaptic disinhibition. Brain Res 997(1):67-78, 2004. e-Pub 2004. PMID: 14715151.
137. Li DP, Chen SR, Finnegan TF, Pan HL. Signalling pathway of nitric oxide in synaptic GABA release in the rat paraventricular nucleus. J Physiol 554(Pt 1):100-10, 2004. e-Pub 2004. PMID: 14678495.
138. Chen SR, Pan HL. Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors. Neuroscience 125:141-148, 2004. e-Pub 2004.
139. Chen SR, Pan HL. Antinociceptive effect of morphine, but not mu opioid receptor number, is attenuated in the spinal cord of diabetic rats. Anesthesiology 99(6):1409-14, 2003. e-Pub 2003. PMID: 14639157.
140. Chen SR, Pan HL. Upregulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats. J Pharmacol Exp Ther 307(2):676-681, 2003. e-Pub 2003. PMID: 12966147.
141. Zahner MR, Li DP, Chen SR, Pan HL. Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol 551.2(Pt 2):515-523, 2003. e-Pub 2003. PMID: 12829722.
142. Li DP, Chen SR, Pan HL. Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. J Neurosci 23(12):5041-9, 2003. e-Pub 2003. PMID: 12832527.
143. Pan HL, Khan GM, Alloway KD, Chen SR. Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action. J Neurosci 23(7):2911-2919, 2003. e-Pub 2003. PMID: 12684478.
144. Chen SR, Pan HL. Spinal GABAB receptors mediate antinociceptive actions of cholinergic agents in normal and diabetic rats. Brain Res 965(1-2):67-74, 2003. e-Pub 2003. PMID: 12591121.
145. Chen SR, Pan HL. Spinal nitric oxide contributes to the analgesic effect of intrathecal [d-pen2,d-pen5]-enkephalin in normal and diabetic rats. Anesthesiology 98(1):217-22, 2003. e-Pub 2003. PMID: 12503000.
146. Khan GM, Li DP, Chen SR, Pan HL. Role of spinal nitric oxide in the inhibitory effect of [D-Pen2, D-Pen5]-enkephalin on ascending dorsal horn neurons in normal and diabetic rats. J Pharmacol Exp Ther 303(3):1021-8, 2002. e-Pub 2002. PMID: 12438523.
147. Chen SR, Sweigart KL, Lakoski JM, Pan HL. Functional mu opioid receptors are reduced in the spinal cord dorsal horn of diabetic rats. Anesthesiology 97(6):1602-8, 2002. e-Pub 2002. PMID: 12459691.
148. Pan YZ, Li DP, Chen SR, Pan HL. Activation of delta-opioid receptors excites spinally projecting locus coeruleus neurons through inhibition of GABAergic inputs. J Neurophysiol 88(5):2675-83, 2002. e-Pub 2002. PMID: 12424303.
149. Li DP, Chen SR, Pan HL. Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release. J Neurophysiol 88(5):2664-74, 2002. e-Pub 2002. PMID: 12424302.
150. Li DP, Chen SR, Pan YZ, Levey AI, Pan HL. Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats. J Physiol 543(Pt 3):807-18, 2002. e-Pub 2002. PMID: 12231640.
151. Chen SR, Pan HL. Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats. J Neurophysiol 87(6):2726-2733, 2002. e-Pub 2002. PMID: 12037174.
152. Sandner-Kiesling A, Pan HL, Chen SR, James RL, DeHaven-Hudkins DL, Dewan DM, Eisenach JC. Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain 96(1-2):13-22, 2002. e-Pub 2002. PMID: 11932057.
153. Pan HL, Chen SR. Myocardial ischemia recruits mechanically insensitive cardiac sympathetic afferents in cats. J Neurophysiol 87(2):660-668, 2002. e-Pub 2002. PMID: 11826035.
154. Chen SR, Wozniak KM, Slusher BS, Pan HL. Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. J Pharmacol Exp Ther 300(2):662-667, 2002. e-Pub 2002. PMID: 11805230.
155. Bantel C, Tobin JR, Li X, Childers SR, Chen SR, Eisenach JC. Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding. Anesthesiology 96(1):103-8, 2002. e-Pub 2002. PMID: 11753009.
156. Khan GM, Chen SR, Pan HL. Role of primary afferent nerves in allodynia caused by diabetic neuropathic pain in rats. Neuroscience 114:291-299, 2002. e-Pub 2002.
157. Bantel C, Chen SR, Eisenach JC, Tobin J. Spinal nerve ligation induces increased lumbar spinal cord expressio of adenosine receptor binding. Anesthesiology 96:103-8, 2002. e-Pub 2002.
158. Chen SR, Xu Z, Pan HL. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. Anesthesiology 95:1473-1479, 2001. e-Pub 2001.
159. Chen SR, Pan HL. Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology 95:525-530, 2001. e-Pub 2001.
160. Chen SR, Khan GM, Pan HL. Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain. Anesthesiology 95:1007-1012, 2001. e-Pub 2001.
161. Pan HL, Deal DD, Xu Z, Chen SR. Differential responses of regional sympathetic activity and blood flow to abdominal visceral afferent stimulation. Am J Physiol 280:R1781-R1789, 2001. e-Pub 2001.
162. Chen SR, Eisenach JC, McCaslin P, Pan HL. Synergistic effect between intrathecal administration of non-NMDA receptor antagonist and gabapentin on experimental neuropathic pain. Anesthesiology 92:500-506, 2000. e-Pub 2000.
163. Xu Z, Chen SR, Eisenach JC, Pan HL. Role of spinal muscarinic and nicotinic receptors in clonidine-induced nitric oxide release in a rat model of neuropathic pain. Brain Res 861:390-398, 2000. e-Pub 2000.
164. Chen SR, Eisenach JC, Pan HL. Intrathecal S-nitroso-N-acetylpenicillamine and L-cysteine attenuate allodynia through noradrenergic activation in a rat model of neuropathic pain. Neuroscience 101:759-765, 2000. e-Pub 2000.
165. Pan HL, Chen SR, Scicli GM, Carretero OA. Cardiac interstitial bradykinin release during ischemia is enhanced by ischemic preconditioning. Am J Physiol (Heat & Circ Physiol) 279:H116-H121, 2000. e-Pub 2000.
166. Zhao Z, Chen SR, Eisenach JC, Busija DW, Pan HL. Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. Neuroscience 97:743-748, 2000. e-Pub 2000.
167. Pan HL, Longhurst JC, Eisenach JC, Chen SR. Role of protons in activation of cardiac sympathetic afferents during ischemia. J Physiol (Lond) 518:857-866, 1999. e-Pub 1999.
168. Pan HL, Eisenach JC, Chen SR. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol and Exp Ther 288:1026-1030, 1999. e-Pub 1999.
169. Pan HL, Chen SR, Eisenach JC. Intrathecal clonidine alleviates allodynia in neuropathic rats: Interaction in spinal muscarinic and nicotinic receptors. Anesthesiology 90:509-514, 1998. e-Pub 1998.
170. Wang MK, Chen SR, Lui J. Serum levels of vitamins D metabolities in children receiving parental nutrition. J Human Nutrition 12:862-870, 1998. e-Pub 1998.
171. Pan HL, Chen SR, Eisenach JC. Role of spinal nitric oxide in antiallodynic effect of intrathecal clonidine in neuropathic rats. Anesthesiology 89:1518-1523, 1998. e-Pub 1998.

Review Articles

1. Huang, Y, Chen, S, Pan, H. α2δ-1-Linked NMDA and AMPA Receptors in Neuropathic Pain and Gabapentinoid Action. Journal of neurochemistry 169(4), 2025. e-Pub 2025. PMID: 40191897.
2. Wu T, Chen SR, Pan HL, Luo Y. The α2δ-1–NMDA receptor complex and its potential as a therapeutic target for ischemic stroke. Front Neurol 14, 2023. e-Pub 2023. PMID: 37153659.
3. Huang, Y, Chen, S, Pan, H. Calcineurin Regulates Synaptic Plasticity and Nociceptive Transmissionat the Spinal Cord Level. Neuroscientist 28(6):628-638, 2022. e-Pub 2022. PMID: 34791930.
4. Deng, M, Chen, S, Pan, H. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cellular and Molecular Life Sciences 76(10):1889-1899, 2019. e-Pub 2019. PMID: 30788514.
5. Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol 4:379-388, 2011. e-Pub 2011. PMID: 21686074.
6. Pan HL, Wu ZZ, Zhou HY, Chen SR, Zhang HM, Li DP. Modulation of pain transmission by G-protein-coupled receptors. Pharmacol Ther 117(1):141-61, 2008. e-Pub 2008. PMID: 17959251.

Other Articles

1. Zhou, J, Luo, Y, Chen, S, Shao, JY, Sah, R, Pan, H Corrigendum to “LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons” [Experimental Neurology, 332(2020)113391]. Experimental Neurology 349, 2022. PMID: 34965898.
2. Chen, J, Li, L, Chen, S, Chen, H, Xie, JD, Sirrieh, RE, MacLean, DM, Zhang, Y, Zhou, M, Jayaraman, V, Pan, H Erratum. Cell Reports 38(4), 2022. PMID: 35081351.

Book Chapters

1. Hou, S, Chen, S, Pan, H. Gene therapy approaches to restore chloride homeostasis for treating neuropathic pain. In: Neuronal Chloride Transporters in Health and Disease. 1. Elsevier Inc, 687-700, 2020.
2. Laumet G, Chen SR, Pan HL. NMDA receptors and signaling in chronic neuropathic pain. In: The NMDA Receptors (Chapter 6). Springer International Publishing AG-Humana Press, 103-119, 2017.
3. Bavencoffe A, Chen SR, Pan HL. Regulation of nociceptive transduction and transmission by nitric oxide. In: Vitam Horm - Nitric Oxide. 96. Elsevier Inc., Academic Press, 1-18, 2014.

Letters to the Editor

1. Huang Y, Chen S, Pan HL. Reply to comments on LTP induced by tetanic stimulation by Li. J Neurosci, 2022.
2. Wu, ZZ, Chen, S, Pan, H. Reply to meriney and lacomis. Journal of Biological Chemistry 293: 16101, 2018.