Sheldon Chen, M.D., F.A.S.N.

Peer-Reviewed Articles

1. Kitchlu A, Costa E Silva VT, Anand S, Kala J, Abudayyeh A, Inker LA, Rosner MH, Karam S, Gudsoorkar P, Gupta S, Chen S, Klomjit N, Leung N, Milanez T, Motwani SS, Khalid SB, Srinivasan V, Wanchoo R, Beumer JH, Liu G, Tannir NM, Orchanian-Cheff A, Geng Y, Herrmann SM. Assessment of Glomerular Filtration Rate in Patients with Cancer: A Statement from the American Society of Onco-Nephrology. Clin J Am Soc Nephrol. e-Pub 2024. PMID: 38848131.
2. Kitchlu A, Costa E Silva VT, Anand S, Kala J, Abudayyeh A, Inker LA, Rosner MH, Karam S, Gudsoorkar P, Gupta S, Chen S, Klomjit N, Leung N, Milanez T, Motwani SS, Khalid SB, Srinivasan V, Wanchoo R, Beumer JH, Liu G, Tannir NM, Orchanian-Cheff A, Geng Y, Herrmann SM. Assessment of GFR in Patients with Cancer Part 2: Anticancer Therapies—Perspectives from the American Society of Onco-Nephrology (ASON). Clin J Am Soc Nephrol. e-Pub 2024.
3. Chen S, Yee J, Chiaramonte R. Safely correct hyponatremia with continuous renal replacement therapy: A flexible, all-purpose method based on the mixing paradigm. Physiol Rep 11(1):e15496, 2023. PMID: 36602098.
4. Chen S, Shey J, Chiaramonte R. Ratio Profile: Physiologic Approach to Estimating Appropriate Intravenous Fluid Rate to Manage Hyponatremia in the Syndrome of Inappropriate Antidiuresis. Kidney360 3(12):2183-2189, 2022. e-Pub 2022. PMID: 36591355.
5. Maulion C, Chen S, Rao VS, Ivey-Miranda JB, Cox ZL, Mahoney D, Coca SG, Negoianu D, Asher JL, Turner JM, Inker LA, Wilson FP, Testani JM. Hemoconcentration of creatinine minimally contributes to changes in creatinine during the treatment of decompensated heart failure. Kidney360 3(6):1003-1010, 2022. e-Pub 2022. PMID: 35845336.
6. Chen S, Chiaramonte R. [Creatinine] can change in an unexpected direction due to the volume change rate that interacts with kinetic GFR: Potentially positive paradox. Physiol Rep 10(3):e15172, 2022. PMID: 35195956.
7. Chen S, Chiaramonte R. In creatinine kinetics, the glomerular filtration rate always moves the serum creatinine in the opposite direction. Physiol Rep 9(16):e14957, 2021. PMID: 34405576.
8. Chen S, Shieh M, Chiaramonte R, Shey J. Improving on the Adrogué-Madias Formula. Kidney360 2(2):365-370, 2021. e-Pub 2020. PMID: 35373033.
9. Kitchlu A, Chan CT, Leung N, Chen S, Latcha S, Tam P. Perspectives from an OncoNephrology Interest Group: Conference Report. Can J Kidney Health Dis 7:1-10, 2020. e-Pub 2020. PMID: 33117547.
10. Chen S, Chiaramonte R. Estimating Creatinine Clearance in the Nonsteady State: The Determination and Role of the True Average Creatinine Concentration. Kidney Med 1(4):207-216, 2019. e-Pub 2019. PMID: 32734201.
11. Mamlouk O, Selamet U, Machado S, Abdelrahim M, Glass WF, Tchakarov A, Gaber L, Lahoti A, Workeneh B, Chen S, Lin J, Abdel-Wahab N, Tayar J, Lu H, Suarez-Almazor M, Tannir N, Yee C, Diab A, Abudayyeh A. Nephrotoxicity of Immune Checkpoint Inhibitors Beyond Tubulointerstitial Nephritis: Single-Center Experience. J Immunother Cancer 7(1):2, 2019. e-Pub 2019. PMID: 30612580.
12. Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD. The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury. PLoS One 14(11):e0225601, 2019. e-Pub 2019. PMID: 31770424.
13. Chen S. Kinetic Glomerular Filtration Rate Equation Can Accommodate a Changing Body Volume: Derivation and Usage of the Formula. Math Biosci 306:97-106, 2018. e-Pub 2018. PMID: 29800561.
14. Chen S, Shey J. Kinetic sodium equation with built-in rate of correction: Aid to prescribing therapy for hyponatremia or hypernatremia. Journal of Onco-Nephrology 1(3):204-212, 2017.
15. Martínez-García C, Izquierdo-Lahuerta A, Vivas Y, Velasco I, Yeo TK, Chen S, Medina-Gomez G. Renal lipotoxicity-associated inflammation and insulin resistance in podocytes affects actin cytoskeleton organization in podocytes. PLoS One 10(11):e0142291, 2015. e-Pub 2015. PMID: 26545114.
16. Chung CH, Fan J, Lee EY, Kang JS, Lee SJ, Pyagay PE, Khoury CC, Yeo TK, Khayat MF, Wang A, Chen S. Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy. Nephron EXTRA 5(1):1-18, 2015. e-Pub 2015. PMID: 25852733.
17. Seok SJ, Lee ES, Kim GT, Hyun M, Lee JH, Chen S, Choi R, Kim HM, Lee EY, Chung CH. Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db mice. Nephrol Dial Transplant 28(7):1700-1710, 2013. e-Pub 2013. PMID: 23794669.
18. Chen S. Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. J Am Soc Nephrol 24(6):877-888, 2013. e-Pub 2013. PMID: 23704286.
19. Khoury CC, Khayat MF, Yeo TK, Pyagay PE, Wang A, Asuncion AM, Sharma K, Yu W, Chen S. Visualizing the mouse podocyte with multiphoton microscopy. Biochem Biophys Res Commun 427(3):525-530, 2012. e-Pub 2012. PMID: 23022193.
20. Lee EY, Chung CH, Khoury CC, Yeo TK, Pyagay PE, Wang A, Chen S. The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-β, increases podocyte motility and albumin permeability. Am J Physiol Renal Physiol 297(1):F85-F94, 2009. e-Pub 2009. PMID: 19420107.
21. Wang A, Ziyadeh FN, Lee EY, Pyagay PE, Sung SH, Sheardown SA, Laping NJ, Chen S. Interference with TGF-β signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. Am J Physiol Renal Physiol 293(5):F1657-F1665, 2007. e-Pub 2007. PMID: 17804483.
22. Cohen MP, Lautenslager GT, Hud E, Shea E, Wang A, Chen S, Shearman CW. Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency. Am J Physiol Renal Physiol 292(2):F789-F795, 2007. e-Pub 2006. PMID: 17018845.
23. Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol 291(5):F995-F1004, 2006. e-Pub 2006. PMID: 16774905.
24. Sung SH, Ziyadeh FN, Wang A, Pyagay PE, Kanwar YS, Chen S. Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. J Am Soc Nephrol 17(11):3093-3104, 2006. e-Pub 2006. PMID: 16988063.
25. Wysocki J, Ye M, Soler MJ, Gurley SB, Xiao HD, Bernstein KE, Coffman TM, Chen S, Batlle D. ACE and ACE2 activity in diabetic mice. Diabetes 55(7):2132-2139, 2006. PMID: 16804085.
26. Cohen MP, Chen S, Ziyadeh FN, Shea E, Hud EA, Lautenslager GT, Shearman CW. Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. Kidney Int 68(4):1554-1561, 2005. PMID: 16164632.
27. Chen S, Lee JS, Iglesias-de la Cruz MC, Wang A, Izquierdo-Lahuerta A, Gandhi NK, Danesh FR, Wolf G, Ziyadeh FN. Angiotensin II stimulates α3(IV) collagen production in mouse podocytes via TGF-β and VEGF signalling: Implications for diabetic glomerulopathy. Nephrol Dial Transplant 20(7):1320-1328, 2005. e-Pub 2005. PMID: 15840669.
28. Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy. Diabetes 54(6):1626-1634, 2005. PMID: 15919782.
29. Chen S, Kasama Y, Lee JS, Jim B, Marin M, Ziyadeh FN. Podocyte-derived vascular endothelial growth factor mediates the stimulation of α3(IV) collagen production by transforming growth factor-β1 in mouse podocytes. Diabetes 53(11):2939-2949, 2004. PMID: 15504975.
30. Chen S, Hoffman BB, Lee JS, Kasama Y, Jim B, Kopp JB, Ziyadeh FN. Cultured tubule cells from TGF-β1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Kidney Int 65(4):1191-1204, 2004. PMID: 15086458.
31. Moreno-Manzano V, Mampaso F, Sepúlveda-Muñoz JC, Alique M, Chen S, Ziyadeh FN, Iglesias-de la Cruz MC, Rodríguez J, Nieto E, Orellana JM, Reyes P, Arribas I, Xu Q, Kitamura M, Lucio Cazana FJ. Retinoids as a potential treatment for experimental puromycin-induced nephrosis. Br J Pharmacol 139(4):823-831, 2003. PMID: 12813006.
32. Cohen MP, Shea E, Chen S, Shearman CW. Glycated albumin increases oxidative stress, activates NF-κB and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-β1 production in macrophage RAW cells. J Lab Clin Med 141(4):242-249, 2003. PMID: 12677169.
33. Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN. Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice. Biochem Biophys Res Commun 300(1):16-22, 2003. PMID: 12480514.
34. Iglesias-de la Cruz MC, Ziyadeh FN, Isono M, Kouahou M, Han DC, Kalluri R, Mundel P, Chen S. Effects of high glucose and TGF-β1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int 62(3):901-913, 2002. PMID: 12164872.
35. Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 296(5):1356-1365, 2002. PMID: 12207925.
36. Cohen MP, Ziyadeh FN, Hong SW, Shearman CW, Hud E, Lautenslager GT, Iglesias-de la Cruz MC, Chen S. Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-β1. Kidney Int 61(6):2025-2032, 2002. PMID: 12028443.
37. Hong SW, Isono M, Chen S, Iglesias-de la Cruz MC, Han DC, Ziyadeh FN. Increased glomerular and tubular expression of transforming growth factor-β1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 158(5):1653-1663, 2001. PMID: 11337363.
38. Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A, Ziyadeh FN. The key role of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy. Ren Fail 23(3-4):471-481, 2001. PMID: 11499562.
39. Han DC, Isono M, Chen S, Casaretto A, Hong SW, Wolf G, Ziyadeh FN. Leptin stimulates type I collagen production in db/db mesangial cells: Glucose uptake and TGF-β type II receptor expression. Kidney Int 59(4):1315-23, 2001. PMID: 11260392.
40. Chen S, Cohen MP, Lautenslager GT, Shearman CW, Ziyadeh FN. Glycated albumin stimulates TGF-β1 production and protein kinase C activity in glomerular endothelial cells. Kidney Int 59(2):673-681, 2001. PMID: 11168949.
41. Iglesias-de la Cruz MC, Ruiz-Torres P, Alcamí J, Díez-Marqués L, Ortega-Velázquez R, Chen S, Rodríguez-Puyol M, Ziyadeh FN, Rodríguez-Puyol D. Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells. Kidney Int 59(1):87-95, 2001. PMID: 11135061.
42. Isono M, Cruz MC, Chen S, Hong SW, Ziyadeh FN. Extracellular signal-regulated kinase mediates stimulation of TGF-β1 and matrix by high glucose in mesangial cells. J Am Soc Nephrol 11(12):2222-2230, 2000. PMID: 11095645.
43. Ziyadeh FN, Hoffman BB, Han DC, Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice. Proc Natl Acad Sci U S A 97(14):8015-8020, 2000. PMID: 10859350.
44. Furst H, Hallows KR, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. The urine/plasma electrolyte ratio: A predictive guide to water restriction. Am J Med Sci 319(4):240-244, 2000. PMID: 10768609.

Invited Articles

1. Perazella MA, Workeneh B, Chen S. Evolution of the kidney-cancer connection. Journal of Onco-Nephrology 3(2):88-91, 2019.
2. Chen S. Hyponatremia in cancer patients: Strategy for safe correction in the hospital. Journal of Onco-Nephrology 3(3):144-150, 2019.
3. Chen S. Kinetic GFR in routine clinical practice-Applications and possibilities. Adv Chronic Kidney Dis 25(1):105-114, 2018. PMID: 29499881.
4. Kanwar YS, Sun L, Xie P, Liu FY, Chen S. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol 6:395-423, 2011. PMID: 21261520.
5. Brosius FC, Khoury CC, Buller CL, Chen S. Abnormalities in signaling pathways in diabetic nephropathy. Expert Rev Endocrinol Metab 5(1):51-64, 2010. PMID: 20224802.
6. Chen S, Ziyadeh FN. Vascular endothelial growth factor and diabetic nephropathy. Curr Diab Rep 8(6):470-476, 2008. PMID: 18990304.
7. Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR. Diabetic nephropathy: Mechanisms of renal disease progression. Exp Biol Med (Maywood) 233(1):4-11, 2008. PMID: 18156300.
8. Chen S, Jalandhara N, Batlle D. Evaluation and management of hyponatremia: An emerging role for vasopressin receptor antagonists. Nat Clin Pract Nephrol 3(2):82-95, 2007. PMID: 17251996.
9. Cohen MP, Ziyadeh FN, Chen S. Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: Pathogenic and therapeutic implications. J Lab Clin Med 147(5):211-219, 2006. PMID: 16697768.
10. Chen S, Jim B, Ziyadeh FN. Diabetic nephropathy and transforming growth factor-β: Transforming our view on glomerulosclerosis and fibrosis buildup. Semin Nephrol 23(6):532-543, 2003. PMID: 14631561.
11. Iglesias-de la Cruz MC, Chen S, Ziyadeh FN, Pancorbo-Alonso, MA. Patogénesis de la nefropatía diabética. Ciencia Al Día Internacional 5(1), 2003.
12. Ziyadeh FN, Isono M, Chen S. Involvement of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy. Clin Exp Nephrol 6(3):125-129, 2002. PMID: 24989950.
13. Wolf G, Chen S, Han DC, Ziyadeh FN. Leptin and renal disease. Am J Kidney Dis 39(1):1-11, 2002. PMID: 11774095.
14. Chen S, Wolf G, Ziyadeh FN. The renin-angiotensin system in diabetic nephropathy. Contributions to Nephrology 135:212-221, 2001. PMID: 11705286.
15. Chen S, Cohen MP, Ziyadeh FN. Amadori-glycated albumin in diabetic nephropathy: Pathophysiologic connections. Kidney Int Suppl 58:S40-S44, 2000. PMID: 10997689.
16. Chen S, Casaretto A, Ziyadeh FN. Pathogenesis of diabetic nephropathy. Science & Medicine 7:10-19, 2000.

Manuals, Teaching Aids, Other Teaching Publications

1. Chen S, Goldfarb S. Diabetic Nephropathy: Nephrology Board Review Manual. Hospital Physician, 2001.
2. Chen S, Ziyadeh FN. Hypertension: Physician Education Material (University of Pennsylvania Intranet), 2000.

Other Articles

1. Chen S, Jalandhara N, Batlle D Erratum: Evaluation and management of hyponatremia: An emerging role for vasopressin receptor antagonists. Nat Clin Pract Nephrol 3:233, 2007.

Abstracts

1. Chen S. Rapid Diagnosis of Hypokalemia in the Setting of a Neuroendocrine Tumor. Poster presented at the American Society of Onco-Nephrology meeting, New York, NY, 2024.
2. Chen S. Avoiding the Paradoxical Worsening of Hyponatremia in SIADH. Poster presented at the American Society of Onco-Nephrology meeting, Boston, MA, 2022.
3. Parvathareddy V, Mukku VK, Polani AS, Chen S. Utility of liquid chromatography in monitoring methotrexate level after Glucarpidase for Methotrexate toxicity. Poster presented at the 54th Annual American Society of Nephrology meeting, San Diego, CA, 2021.
4. Polani AS, Reddy VD, Mukku VK, Parvathareddy V, Chen S. A Rare Cause of Hyponatremia: Renal Salt Wasting Syndrome of Unclear Etiology Post Autologous Hematopoietic Stem Cell Transplant. Poster presented at the 54th Annual American Society of Nephrology meeting, San Diego, CA, 2021.
5. Chen S. How to Estimate Kidney Function in AKI via the Basic Clearance: Role of the True Average [Creatinine]. Poster presented at the 52nd Annual American Society of Nephrology meeting, Washington, DC, 2019.
6. Abudayyeh A, Kalu CO, Lakhani LS, Workeneh B, Lahoti A, Chen S, Danesh FR, Abdelrahim M. Incidence of AKI in a Large Retrospective Cancer Cohort Using Checkpoint Inhibitors. 51st Annual American Society of Nephrology, San Diego, CA, 2018.
7. Kwong YD, Chen S, Liu KD. Impact of Kinetic Glomerular Filtration Rate Estimation on Medication Dosing in AKI. Oral Communication presented at the 51st Annual American Society of Nephrology meeting, San Diego, CA, 2018.
8. Chen S. Improving the Kinetic GFR by Taking Volume Changes into Account. Poster presented at the 51st Annual American Society of Nephrology meeting, San Diego, CA, 2018.
9. Chen S. New Sodium Equation with Built-In Rate of Correction to Simplify Therapeutic Orders for Hyponatremia or Hypernatremia. Poster presented at the 50th Annual American Society of Nephrology meeting, New Orleans, LA, 2017.
10. Safdi A, Ahya SN, Kanwar YS, Chen SC. Horsetail Tea Ingestion and End-Stage Renal Disease: An Unrecognized Form of Silica Associated Nephropathy?. Poster presented at the 46th Annual American Society of Nephrology meeting, Atlanta, GA, 2013.
11. Martínez García C, Yeo TK, Vivas García Y, Izquierdo Lahuerta A, Chen S, Medina-Gómez G. Study of lipotoxicity mechanisms of Palmitic acid in murine podocytes. Presented at the 55th Congress of Nutrition and Endocrinology Spanish Society, 2013.
12. Chen S. Retooling the creatinine clearance equation to estimate kidney function when the serum creatinine is changing acutely: Kinetic eGFR formula. Poster presented at the 45th Annual American Society of Nephrology meeting, San Diego, CA, 2012.
13. Khayat MF, Khoury CC, Yeo TK, Pyagay P, Yu W, Chen SC. Intravital Multiphoton Imaging of Mouse Podocytes. Oral Communication talk at the 44th Annual American Society of Nephrology meeting, Philadelphia, PA, 2011.
14. Khoury CC, Chen S. Looking at the podocyte through a new lens: Multiphoton microscopy of the mouse glomerulus. Poster presented at the Lewis Landsberg Research Day, Northwestern University, 2011.
15. Yeo TK, Chen S. Snail and Zeb2: A transcription factor tag team in podocyte plasticity. Poster presented at the Lewis Landsberg Research Day, Northwestern University, 2011.
16. Fan J, Chung CH, Lee EY, Pyagay P, Wang A, Chen SC. TNF-α affects podocyte expression of collagen IV and integrin α3: Role of PI3K and MCP-1. Poster presented at the 43rd Annual American Society of Nephrology meeting, Denver, CO, 2010.
17. Yeo TK, Khoury CC, Chen SC. Can podocytes undergo epithelial-to-mesenchymal transition?. Poster presented at the 43rd Annual American Society of Nephrology meeting, Denver, CO, 2010.
18. Yeo TK, Khoury CC, Lee EY, Pyagay PE, Chang A, Wang A, Chen S. Beyond inflammation: The effect of CCR2-knockout (KO) on diabetic nephropathy and albuminuria. Oral Communication talk at the 42nd Annual American Society of Nephrology meeting, 2009.
19. Lee EY, Chung CH, Pyagay P, Wang A, Chen S. The pleiotropic effects of monocyte chemoattractant protein-1 increase podocyte motility and albumin permeability: Evidence for a podocytic MCP-1 autocrine loop in diabetes. Poster presented at the 41st Annual American Society of Nephrology meeting, Philadelphia, PA, 2008.
20. Lee EY, Chung CH, Wang A, Pyagay P, Chen S. The TGF-β-stimulated production of monocyte chemoattractant protein (MCP)-1 by podocytes influences podocyte motility and permeability: Evidence for an MCP-1 autocrine loop. Poster presented at the 2008 Annual Meeting of the Central Society for Clinical Research (CSCR), Chicago, IL, 2008.
21. Lee EY, Chung CH, Wang A, Pyagay P, Chen S. Podocyte-derived monocyte chemoattractant protein (MCP)-1 is stimulated by TGF-β and might contribute to diabetic nephropathy. Poster presented at the 40th Annual American Society of Nephrology meeting, San Francisco, CA, 2007.
22. Chen S, Wang A, Pyagay P, Kanwar YS, Ziyadeh FN. VEGF signaling blockade ameliorates diabetic albuminuria in mice: Effects on the kidney podocyte. Poster presented at the 2007 Annual Meeting of the Central Society for Clinical Research (CSCR), Chicago, IL, 2007.
23. Wang A, Pyagay P, Chen S. Paradoxical nephrin dysregulation in the db/db mouse model of diabetic nephropathy. Poster presented at the 39th Annual American Society of Nephrology meeting, San Diego, CA, 2006.
24. Chen S, Sung SH, Laping NJ, Ziyadeh FN. Blockade of VEGF Signaling, But Not Knockout of TGF-β/Smad3 Signaling, Ameliorates Diabetic Albuminuria in Mice, Possibly Via Effects on Nephrin. Poster presented at the 38th Annual American Society of Nephrology meeting, Philadelphia, PA, 2005.
25. Chen S, Sung SH, Laping NJ, Ziyadeh FN. VEGF signaling, but not Smad3 signaling, engenders albuminuria in diabetic nephropathy, possibly via alterations in nephrin expression. Oral Communication invited at the World Congress of Nephrology meeting, Singapore, 2005.
26. Chen S, Lee J, Kasama Y, Marin M, Ziyadeh FN, Sung SH. TGF-β1 stimulation of α3(IV) collagen production in mouse podocytes is partly mediated by a VEGF autocrine loop involving PI3K and PKC. Oral Communication presented at the 37th Annual American Society of Nephrology meeting, St. Louis, MO, 2004.
27. Sung SH, Chen S, Laping NJ, Ziyadeh FN. Albuminuria is ameliorated by an inhibitor of VEGF receptors, SU5416, in diabetic db/db mice but is unaffected in Smad3-knockout mice rendered diabetic with streptozotocin. Poster presented at the 37th Annual American Society of Nephrology meeting, St. Louis, MO, 2004.
28. Chen S, Lee JS, Hoffman BB, Ziyadeh FN. Cultured tubule cells from TGF-β1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Poster presented at the 36th Annual American Society of Nephrology meeting, San Diego, CA, 2003.
29. Chen S, Kasama Y, Lee JS, Jim B, Ziyadeh FN. VEGF stimulates the production of collagen IV by mouse podocytes in an autocrine loop. Oral Communication presented at the 36th Annual American Society of Nephrology meeting, San Diego, CA, 2003.
30. Chen S, Hong SW, Jim B, Lee JS, Kouahou M, Ziyadeh FN. Metabolic mediators of transforming growth factor-β activation in mouse podocytes. Oral Communication presented at the World Congress of Nephrology 2003 meeting, Berlin, Germany, 2003.
31. Chen S, Iglesias-de la Cruz MC, Kouahou M, Ziyadeh FN. The TGF-β system mediates some of the high glucose effects on differentiated mouse podocytes. Poster presented at the 35th Annual American Society of Nephrology meeting, Philadelphia, PA, 2002.
32. Chen S, Iglesias-de la Cruz MC, Ziyadeh FN, Mundel P. High glucose and TGF-β1 affect mouse podocyte expression of collagen IV and VEGF in similar and disparate ways. Presented at the University of Pennsylvania Department of Medicine Research Day, Philadelphia, PA, 2002.
33. Isono M, Chen S, Iglesias-de la Cruz MC, Hong SW, Ziyadeh FN. Activation of renal Smad signaling pathway in diabetic mice and regulation of fibronectin expression in mesangial cells cultured in high glucose. Poster presented at the 34th Annual American Society of Nephrology meeting, San Francisco, CA, 2001.
34. Ziyadeh FN, Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S. Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice. Poster presented at the 34th Annual American Society of Nephrology meeting, San Francisco, CA, 2001.
35. Iglesias-de la Cruz MC, Chen S, Isono M, Mundel P, Ziyadeh FN. Disparate effects of high glucose and TGF-β1 on type IV collagen expression in cultured mouse podocytes. Poster presented at the 34th Annual American Society of Nephrology meeting, San Francisco, CA, 2001.
36. Chen S, Cohen MP, Ziyadeh FN. Glycated albumin stimulates PKC activity and TGF-β1 production in glomerular endothelial cells. Poster presented at the 33rd Annual American Society of Nephrology meeting, Toronto, Canada, 2000.
37. Iglesias-de la Cruz C, Chen S, Wolf G, Mundel P, Ziyadeh FN. High glucose and angiotensin II stimulate TGF-β type II receptor and α5(IV) collagen expression in cultured mouse podocytes. Oral communication presented at the 33rd Annual American Society of Nephrology meeting, Toronto, Canada, 2000.
38. Chen S, Lee BJ, Guo J, Post JB, Gehret JA, Danoff TM, Ziyadeh FN. Anti-TGF-β antibody treatment ameliorates fibrosis in unilateral ureteral obstruction. Poster presented at the 32nd Annual American Society of Nephrology meeting, Miami Beach, FL, 1999.
39. Han DC, Chen S, Hong SW, Iglesias de la Cruz MC, Ziyadeh FN. Increased expression of TGF-β1, VEGF, and fibronectin in rat glomerular endothelial cells by high ambient glucose. Poster presented at the 32nd Annual American Society of Nephrology meeting, Miami Beach, FL, 1999.
40. Cohen MP, Chen S, Ziyadeh FN. Glycated albumin (GA) modulates glomerular endothelial cell biology. Abstract for American Diabetes Association 59th Scientific Session, 1999.
41. Chen S, Guo J, Cohen JA, Cohen MP, Ziyadeh FN. Amadori-modified albumin increases extracellular matrix mRNA and protein levels by stimulating PKC signaling and the TGF-β system in cultured mouse mesangial cells. XVth International Congress of Nephrology, Buenos Aires, Argentina, 1999.

Book Chapters

1. Khoury CC, Chen S, Ziyadeh FN. Mechanisms of Diabetic Nephropathy in Humans and Experimental Animals. In: Blood Pressure Disorders in Diabetes Mellitus. 1st edition. Springer Nature: Switzerland, 129-151, 2023.
2. Lahoti A, Chen S. Acute Kidney Injury: Incidence, Pathogenesis, and Outcomes. In: Onco-Nephrology. 1st edition. Elsevier: Philadelphia, PA, 270-274, 2020.
3. Khoury CC, Chen S, Ziyadeh FN. Pathophysiology of Diabetic Kidney Disease. In: Chronic Renal Disease. 2nd edition. Elsevier: Amsterdam, 279-296, 2019.
4. Khoury CC, Chen S, Ziyadeh FN. Pathophysiology of Diabetic Nephropathy. In: Chronic Renal Disease. 1st edition. Elsevier: Amsterdam, 151-162, 2014.
5. Chen S, Khoury C, Ziyadeh FN. Pathophysiology and pathogenesis of diabetic nephropathy. In: Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology. 5th edition. Elsevier: Amsterdam, 2605-2632, 2013.
6. Batlle D, Chen S, Haque SK. Physiologic principles in the clinical evaluation of electrolyte, water, and acid-base disorders. In: Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology. 5th edition. Elsevier: Amsterdam, 2477-2511, 2013.
7. Chen S, Ziyadeh FN. Transforming Growth Factor-β signal transduction in the pathogenesis of diabetic nephropathy: Identifying molecular targets for therapeutic intervention. In: Contemporary Diabetes: The Diabetic Kidney. 1st edition. The Humana Press: Totowa, NJ, 201-221, 2006.
8. Jim B, Chen S, Ziyadeh FN. Transforming growth factor-β and other cytokines in experimental and human diabetic nephropathy. In: The Kidney and Hypertension in Diabetes Mellitus. 1st edition. Taylor & Francis Group: London, 397-432, 2004.
9. Chen S, Iglesias-de la Cruz MC, Isono M, Ziyadeh FN. Transforming growth factor-β and other cytokines in experimental and human diabetic nephropathy. In: The Kidney and Hypertension in Diabetes Mellitus. 5th edition. Kluwer Academic Publishers: Norwell, 313-338, 2000.

Letters to the Editor

1. Chen S, Shey J. Response to "Kinetic sodium equation". Journal of Onco-Nephrology 2: 33-34, 2018.