Sheldon Chen, M.D., F.A.S.N.
Department of Emergency Medicine, Division of Internal Medicine
About Dr. Sheldon Chen
Dr. Sheldon Chen is a Professor in the Section of Nephrology. He trained at the University of Pennsylvania and was previously faculty at Northwestern University. He is board-certified in Nephrology and joined MD Anderson in 12/2014.
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Present Title & Affiliation
Primary Appointment
Professor, Department of Emergency Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Professor, Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Postgraduate Training
| 1997-2002 | Clinical Fellowship, Nephrology, University of Pennsylvania, Philadelphia, Pennsylvania |
| 1995-1997 | Clinical Residency, Internal Medicine, University of Michigan Hospitals, Ann Arbor, Michigan |
| 1994-1995 | Clinical Internship, Internal Medicine, University of Michigan Hospitals, Ann Arbor, Michigan |
Licenses & Certifications
| 2020 | Nephrology |
| 2014 | Texas |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2021
Assistant Professor, The Graduate School of Northwestern University, Evanston, IL, 2007 - 2014
Assistant Professor, Jesse Brown Veterans Affairs Hospital, Chicago, IL, 2006 - 2014
Assistant Professor, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2005 - 2014
Instructor, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2002 - 2005
Administrative Appointments/Responsibilities
Fellowship Program Director, Department of Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - Present
Education Director (Division level), Department of Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - Present
Co-Chair of Bayou City Bean Club, Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - Present
Chair of Onco-Nephrology Symposium 2018, Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2018 - 2018
Coordinator of Hyponatremia Clinic, Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2020
Chair of Onco-Nephrology Symposium 2016, Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2016
Education Director (Department level), Department of Medicine, Northwestern University, Chicago, IL, 2013 - 2014
Other Professional Positions
Consultant, La Jolla Pharmaceuticals, Houston, Texas, 2018
Consultant, Janssen Pharmaceuticals, Raritan, New Jersey, 2013
Consultant, Janssen Pharmaceuticals, Raritan, New Jersey, 2012
Extramural Institutional Committee Activities
Co-leader of "Educate the Educator" working group, Division of Internal Medicine Education Committee, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, 2020 - 2022
Member, Department of Medicine Research Council, Northwestern University Feinberg School of Medicine, The University of Texas MD Anderson Cancer Center, 2006 - 2009
Member, Fellowship Task Force of the Department of Medicine Research Council, Northwestern University Feinberg School of Medicine, The University of Texas MD Anderson Cancer Center, 2006 - 2008
Editorial Activities
Editor, Abstract Category Chair for "1505 Cell Biology: Glomerular" at the 46th Annual American Society of Nephrology meeting, 2013
Editor, American Journal of Physiology-Renal Physiology, 2007 - 2020
Honors & Awards
| 2024 | Best Poster Presentation, American Society of Onco-Nephrology |
| 2008 - 2009 | Outstanding Teacher Award, Northwestern University |
| 2006 | IDEAS charter member, Northwestern University |
| 2005 - 2024 | Fellow of the American Society of Nephrology, ASN |
| 2002 | Renal Fellows Teaching Award, University of Pennsylvania |
| 1999 | First place in Fellows Research Forum, National Kidney Foundation |
| 1994 | Alpha Omega Alpha Medical Honor Society, ΑΩΑ |
| 1994 | Degree, Doctor of Medicine with Honor, Baylor College of Medicine |
| 1994 | Merck Manual Award, Merck |
| 1992 | High Honors for performance in Basic Sciences, Baylor College of Medicine |
| 1991 | Outstanding Student Scholarship, Chinese-American Educational Fund |
| 1990 - 1994 | Presidential Scholarship, Baylor College of Medicine |
| 1990 | Degree, Bachelor of Arts with Honor, Johns Hopkins University |
| 1989 | Phi Beta Kappa, ΦΒΚ |
| 1986 - 1990 | Dean's List, Johns Hopkins University |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2024. Controversies and Emerging Therapies in IgA Nephropathy and GN. Conference. National Kidney Foundation. Houston, TX, US.
- 2018. Hyponatremia: Strategy for Safe Correction in the Hospital. Conference. MD Anderson Onco-Nephrology Symposium 2018. Houston, TX, US.
Regional Presentations
- 2017. Acute Kidney Injury in Cancer Patients. Conference. Memorial Sloan Kettering Cancer Center. New York, NY, US.
- 2011. Looking at the podocyte through a new lens: Multiphoton microscopy of the mouse glomerulus. Conference. Northwestern University Lewis Landsberg Research Day. Chicago, IL, US.
- 2011. Snail and Zeb2: A transcription factor tag team in podocyte plasticity. Conference. Northwestern University Lewis Landsberg Research Day. Chicago, IL, US.
- 2008. The TGF-β-stimulated production of monocyte chemoattractant protein (MCP)-1 by podocytes influences podocyte motility and permeability: Evidence for an MCP-1 autocrine loop. Conference. Central Society for Clinical Research. Chicago, IL, US.
- 2007. VEGF signaling blockade ameliorates diabetic albuminuria in mice: Effects on the kidney podocyte. Conference. Central Society for Clinical Research. Chicago, IL, US.
- 2002. High glucose and TGF-β1 affect mouse podocyte expression of collagen IV and VEGF in similar and disparate ways. Conference. University of Pennsylvania Department of Medicine Research Day. Philadelphia, PA, US.
National Presentations
- 2023. Hyponatremia and Cancer. Invited. American Society of Onco-Nephrology. Houston, TX, US.
- 2020. Dysnatremias in Cancer. Invited. National Kidney Foundation. New Orleans, LA, US.
- 2020. Kinetic eGFR to Assess Rapidly Changing Kidney Function. Invited. National Kidney Foundation. New Orleans, LA, US.
- 2019. How to estimate kidney function in AKI via the basic clearance: Role of the true average [creatinine]. Conference. American Society of Nephrology. Washington, DC, US.
- 2018. Impact of Kinetic Glomerular Filtration Rate Estimation on Medication Dosing in AKI. Invited. American Society of Nephrology. San Diego, CA, US.
- 2018. Improving the kinetic GFR by taking volume changes into account. Conference. American Society of Nephrology. San Diego, CA, US.
- 2017. New sodium equation with built-in rate of correction to simplify therapeutic orders for hyponatremia or hypernatremia. Conference. American Society of Nephrology. New Orleans, LA, US.
- 2016. Retooling Creatinine Clearance Estimation with Acutely Changing Serum Creatinine. Invited. American Society for Microbiology (combined with ICAAC). Boston, MA, US.
- 2015. Estimating Kinetic GFR in the Setting of AKI: Is It Useful?. Invited. American Society of Nephrology. San Diego, CA, US.
- 2013. Horsetail tea ingestion and end-stage renal disease: An unrecognized form of silica associated nephropathy?. Conference. American Society of Nephrology. Atlanta, GA, US.
- 2012. Retooling the creatinine clearance equation to estimate kidney function when the serum creatinine is changing acutely: Kinetic eGFR formula. Conference. American Society of Nephrology. San Diego, CA, US.
- 2011. Intravital Multiphoton Imaging of Mouse Podocytes. Invited. American Society of Nephrology. Philadelphia, PA, US.
- 2010. Chemokine signaling in podocyte motility and albumin permeability. Invited. American Society of Nephrology. Denver, CO, US.
- 2010. Can podocytes undergo epithelial-to-mesenchymal transition?. Conference. American Society of Nephrology. Denver, CO, US.
- 2010. TNF-α affects podocyte expression of collagen IV and integrin α3: Role of PI3K and MCP-1. Conference. American Society of Nephrology. Denver, CO, US.
- 2009. Beyond inflammation: The effect of CCR2-knockout (KO) on diabetic nephropathy and albuminuria. Invited. American Society of Nephrology. San Diego, CA, US.
- 2008. The pleiotropic effects of monocyte chemoattractant protein-1 increase podocyte motility and albumin permeability: Evidence for a podocytic MCP-1 autocrine loop in diabetes. Conference. American Society of Nephrology. Philadelphia, PA, US.
- 2007. Podocyte-derived monocyte chemoattractant protein (MCP)-1 is stimulated by TGF-β and might contribute to diabetic nephropathy. Conference. American Society of Nephrology. San Francisco, CA, US.
- 2006. Paradoxical nephrin dysregulation in the db/db mouse model of diabetic nephropathy. Conference. American Society of Nephrology. San Diego, CA, US.
- 2005. Blockade of VEGF signaling, but not knockout of TGF-β/Smad3 signaling, ameliorates diabetic albuminuria in mice, possibly via effects on nephrin. Conference. American Society of Nephrology. Philadelphia, PA, US.
- 2004. Albuminuria is ameliorated by an inhibitor of VEGF receptors, SU5416, in diabetic db/db mice but is unaffected in Smad3-knockout mice rendered diabetic with streptozotocin. Conference. American Society of Nephrology. St. Louis, MO, US.
- 2004. TGF-β1 stimulation of α3(IV) collagen production in mouse podocytes is partly mediated by a VEGF autocrine loop involving PI3K and PKC. Invited. American Society of Nephrology. St. Louis, MO, US.
- 2003. VEGF stimulates the production of collagen IV by mouse podocytes in an autocrine loop. Invited. American Society of Nephrology. San Diego, CA, US.
- 2003. Cultured tubule cells from TGF-β1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Conference. American Society of Nephrology. San Diego, CA, US.
- 2002. The TGF-β system mediates some of the high glucose effects on differentiated mouse podocytes. Conference. American Society of Nephrology. Philadelphia, PA, US.
- 2001. Disparate effects of high glucose and TGF-β1 on type IV collagen expression in cultured mouse podocytes. Conference. American Society of Nephrology. San Francisco, CA, US.
- 2001. Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice. Conference. American Society of Nephrology. San Francisco, CA, US.
- 2001. Activation of renal Smad signaling pathway in diabetic mice and regulation of fibronectin expression in mesangial cells cultured in high glucose. Conference. American Society of Nephrology. San Francisco, CA, US.
- 1999. Anti-TGF-β antibody treatment ameliorates fibrosis in unilateral ureteral obstruction. Conference. American Society of Nephrology. Miami Beach, FL, US.
- 1999. Increased expression of TGF-β1, VEGF, and fibronectin in rat glomerular endothelial cells by high ambient glucose. Conference. American Society of Nephrology. Miami Beach, FL, US.
- 1999. Glycated albumin (GA) modulates glomerular endothelial cell biology. Conference. American Diabetes Association. San Diego, CA, US.
International Presentations
- 2019. Electrolyte Disturbances Associated with Cancer. Invited. Canadian Society of Nephrology. Montreal, CA.
- 2005. VEGF signaling, but not Smad3 signaling, engenders albuminuria in diabetic nephropathy, possibly via alterations in nephrin expression. Invited. World Congress of Nephrology. Singapore, SG.
- 2003. Metabolic mediators of transforming growth factor-β activation in mouse podocytes. Invited. World Congress of Nephrology. Berlin, DE.
- 2000. Glycated albumin stimulates PKC activity and TGF-β1 production in glomerular endothelial cells. Conference. American Society of Nephrology. Toronto, CA.
- 2000. High glucose and angiotensin II stimulate TGF-β type II receptor and α5(IV) collagen expression in cultured mouse podocytes. Invited. American Society of Nephrology. Toronto, CA.
- 1999. Amadori-modified albumin increases extracellular matrix mRNA and protein levels by stimulating PKC signaling and the TGF-β system in cultured mouse mesangial cells. Conference. International Congress of Nephrology. Buenos Aires, AR.
Formal Peers
- 2023. Hyponatremia and Cancer. Invited. Houston, TX, US.
- 2022. Why normal saline can paradoxically worsen hyponatremia in SIADH. Invited. Houston, TX, US.
- 2021. Kinetic GFR: Photo vs. Film. Invited. Houston, TX, US.
- 2021. Improving on the Adrogué-Madias Equation. Invited. Houston, TX, US.
- 2019. Kinetic GFR: How to Track the Kidney Function in AKI and Recovery. Invited. Houston, TX, US.
- 2018. Hyponatremia for Journal Club. Invited. Houston, TX, US.
- 2017. Acute Kidney Injury in Cancer Patients. Invited. New York, NY, US.
- 2008. Diabetic Nephropathy and the Role of VEGF Signaling. Visiting. Chicago, IL, US.
- 2007. Focus on VEGF Signaling in Diabetic Albuminuria. Visiting. Dearborn, MI, US.
- 2004. Pathogenesis of Diabetic Nephropathy: Focus on TGF-β and VEGF. Visiting. Osaka, JP.
- 2004. Pathogenesis of Diabetic Nephropathy: Focus on TGF-β and VEGF. Visiting. Nagoya, JP.
- 2004. Molecular Mechanisms of Diabetic Nephropathy. Invited. Nagoya, JP.
- 2004. Pathogenesis of Diabetic Nephropathy: Focus on TGF-β and VEGF. Visiting. Okayama, JP.
- 2000. Modulation of Mesangial Cell Matrix Production by Glycated Albumin: Implications for Diabetic Nephropathy. Invited. Madrid, ES.
Grant & Contract Support
| Date: | 2012 - 2012 |
| Title: | Graduate Training in Research Abroad |
| Funding Source: | Government of Spain |
| Role: | Project Leader |
| Date: | 2011 - 2012 |
| Title: | Nephrology Fellowship Training Grant |
| Funding Source: | International Society of Nephrology |
| Role: | Project Leader |
| Date: | 2008 - 2012 |
| Title: | Investigating the Mechanisms of VEGF in Diabetic Albuminuria |
| Funding Source: | Veterans Administration Merit Review Award |
| Role: | PI |
| Date: | 2008 |
| Title: | K Award Grant |
| Funding Source: | Central Society for Clinical Research |
| Role: | CSCR meeting |
| Date: | 2007 - 2008 |
| Title: | International Fellowship Program |
| Funding Source: | International Society of Nephrology |
| Role: | Project Leader |
| Date: | 2007 |
| Title: | K Award Grant |
| Funding Source: | Central Society for Clinical Research |
| Role: | CSCR meeting |
| Date: | 2007 - 2012 |
| Title: | Angiotensin II, TGF-β, and the Podocyte in Diabetes |
| Funding Source: | NIH/NIDDK |
| Role: | Principal Investigator, R01 |
| ID: | 1-R01-DK044513-11 |
| Date: | 2006 - 2008 |
| Title: | Diabetic Albuminuria and VEGF and Nephrin |
| Funding Source: | NIH/NIDDK |
| Role: | Principal Investigator, R03 |
| ID: | R03 Small Grant Program for NIDDK K08 Recipients |
| Date: | 2006 - 2008 |
| Title: | GlaxoSmithKline Young Investigator Grant |
| Funding Source: | National Kidney Foundation |
| Role: | PI |
| Date: | 2006 - 2007 |
| Title: | International Fellowship Program |
| Funding Source: | International Society of Nephrology |
| Role: | Project Leader |
| Date: | 2006 - 2007 |
| Title: | Charter Member, Department of Medicine Investigators Developing Excellence in Academics |
| Funding Source: | Northwestern University |
| Role: | PI |
| Date: | 2006 - 2006 |
| Title: | An Inhibitor of VEGF Receptor Signaling in the Treatment of Experimental Diabetic Nephropathy |
| Funding Source: | Northwestern Memorial Foundation Innovation Award |
| Role: | PI |
| Date: | 2005 |
| Title: | Advances in Research Conference |
| Funding Source: | American Society of Nephrology |
| Role: | ASN travel grant |
| Date: | 2003 |
| Title: | Professional Development Seminar |
| Funding Source: | American Society of Nephrology |
| Role: | ASN travel grant |
| Date: | 2002 - 2008 |
| Title: | Podocyte Dysfunction in Diabetic Glomerulopathy |
| Funding Source: | NIH/NIDDK |
| Role: | K08 Mentored Clinical Scientist Development Award |
| ID: | DK-61537 |
| Date: | 2000 - 2002 |
| Title: | Role of Glycated Albumin in Diabetic Nephropathy |
| Funding Source: | NIH/NIDDK |
| Role: | Individual National Research Service Award (NRSA) |
| ID: | DK-09993 |
| Date: | 1999 - 2000 |
| Title: | The Role of Glycated Albumin in the Pathogenesis of Diabetic Nephropathy |
| Funding Source: | Juvenile Diabetes Research Foundation |
| Role: | Postdoctoral Fellow grant |
| ID: | 3-1999-19 |
| Date: | 1999 - 2001 |
| Title: | Franklin D. McDonald, M.D. Postdoctoral Research Fellowship |
| Funding Source: | National Kidney Foundation |
| Role: | Postdoctoral Fellow |
Selected Publications
Peer-Reviewed Articles
- Kitchlu, A, Silva, VE, Anand, S, Kala, J, Abudayyeh, A, Inker, L, Rosner, M, Karam, S, Gudsoorkar, P, Gupta, S, Chen, S, Klomjit, N, Leung, N, Milanez, T, Motwani, SS, Khalid, SB, Srinivasan, V, Wanchoo, R, Beumer, JH, Liu, G, Tannir, NM, Orchanian-Cheff, A, Geng, Y, Herrmann, SM. Assessment of GFR in Patients with Cancer Part 2: Anticancer Therapies—Perspectives from the American Society of Onco-Nephrology (ASON). Clinical Journal of the American Society of Nephrology 19(8):1073-1077, 2024. e-Pub 2024. PMID: 39316409.
- Kitchlu A, Costa E Silva VT, Anand S, Kala J, Abudayyeh A, Inker LA, Rosner MH, Karam S, Gudsoorkar P, Gupta S, Chen S, Klomjit N, Leung N, Milanez T, Motwani SS, Khalid SB, Srinivasan V, Wanchoo R, Beumer JH, Liu G, Tannir NM, Orchanian-Cheff A, Geng Y, Herrmann SM. Assessment of GFR in Patients with Cancer: A Statement from the American Society of Onco-Nephrology. Clin J Am Soc Nephrol 19(8):1061-1072, 2024. e-Pub 2024. PMID: 38848131.
- Chen S, Yee J, Chiaramonte R. Safely correct hyponatremia with continuous renal replacement therapy: A flexible, all-purpose method based on the mixing paradigm. Physiol Rep 11(1):e15496, 2023. e-Pub 2023. PMID: 36602098.
- Chen S, Shey J, Chiaramonte R. Ratio Profile: Physiologic Approach to Estimating Appropriate Intravenous Fluid Rate to Manage Hyponatremia in the Syndrome of Inappropriate Antidiuresis. Kidney360 3(12):2183-2189, 2022. e-Pub 2022. PMID: 36591355.
- Maulion C, Chen S, Rao VS, Ivey-Miranda JB, Cox ZL, Mahoney D, Coca SG, Negoianu D, Asher JL, Turner JM, Inker LA, Wilson FP, Testani JM. Hemoconcentration of creatinine minimally contributes to changes in creatinine during the treatment of decompensated heart failure. Kidney360 3(6):1003-1010, 2022. e-Pub 2022. PMID: 35845336.
- Chen S, Chiaramonte R. [Creatinine] can change in an unexpected direction due to the volume change rate that interacts with kinetic GFR: Potentially positive paradox. Physiol Rep 10(3):e15172, 2022. e-Pub 2022. PMID: 35195956.
- Chen S, Chiaramonte R. In creatinine kinetics, the glomerular filtration rate always moves the serum creatinine in the opposite direction. Physiol Rep 9(16):e14957, 2021. e-Pub 2021. PMID: 34405576.
- Chen S, Shieh M, Chiaramonte R, Shey J. Improving on the Adrogué-Madias Formula. Kidney360 2(2):365-370, 2021. e-Pub 2021. PMID: 35373033.
- Kitchlu A, Chan CT, Leung N, Chen S, Latcha S, Tam P. Perspectives from an OncoNephrology Interest Group: Conference Report. Can J Kidney Health Dis 7:1-10, 2020. e-Pub 2020. PMID: 33117547.
- Mamlouk O, Selamet U, Machado S, Abdelrahim M, Glass WF, Tchakarov A, Gaber L, Lahoti A, Workeneh B, Chen S, Lin J, Abdel-Wahab N, Tayar J, Lu H, Suarez-Almazor M, Tannir N, Yee C, Diab A, Abudayyeh A. Nephrotoxicity of Immune Checkpoint Inhibitors Beyond Tubulointerstitial Nephritis: Single-Center Experience. J Immunother Cancer 7(1):2, 2019. e-Pub 2019. PMID: 30612580.
- Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD. The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury. PLoS One 14(11):e0225601, 2019. e-Pub 2019. PMID: 31770424.
- Chen S. Kinetic Glomerular Filtration Rate Equation Can Accommodate a Changing Body Volume: Derivation and Usage of the Formula. Math Biosci 306:97-106, 2018. e-Pub 2018. PMID: 29800561.
- Chen S, Shey J. Kinetic sodium equation with built-in rate of correction: Aid to prescribing therapy for hyponatremia or hypernatremia. Journal of Onco-Nephrology 1(3):204-212, 2017. e-Pub 2017.
- Martínez-García C, Izquierdo-Lahuerta A, Vivas Y, Velasco I, Yeo TK, Chen S, Medina-Gomez G. Renal lipotoxicity-associated inflammation and insulin resistance in podocytes affects actin cytoskeleton organization in podocytes. PLoS One 10(11):e0142291, 2015. e-Pub 2015. PMID: 26545114.
- Seok SJ, Lee ES, Kim GT, Hyun M, Lee JH, Chen S, Choi R, Kim HM, Lee EY, Chung CH. Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db mice. Nephrol Dial Transplant 28(7):1700-1710, 2013. e-Pub 2013. PMID: 23794669.
- Chen S. Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. J Am Soc Nephrol 24(6):877-888, 2013. e-Pub 2013. PMID: 23704286.
- Khoury CC, Khayat MF, Yeo TK, Pyagay PE, Wang A, Asuncion AM, Sharma K, Yu W, Chen S. Visualizing the mouse podocyte with multiphoton microscopy. Biochem Biophys Res Commun 427(3):525-530, 2012. e-Pub 2012. PMID: 23022193.
- Lee EY, Chung CH, Khoury CC, Yeo TK, Pyagay PE, Wang A, Chen S. The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-β, increases podocyte motility and albumin permeability. Am J Physiol Renal Physiol 297(1):F85-F94, 2009. e-Pub 2009. PMID: 19420107.
- Wang A, Ziyadeh FN, Lee EY, Pyagay PE, Sung SH, Sheardown SA, Laping NJ, Chen S. Interference with TGF-β signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. Am J Physiol Renal Physiol 293(5):F1657-F1665, 2007. e-Pub 2007. PMID: 17804483.
- Cohen MP, Lautenslager GT, Hud E, Shea E, Wang A, Chen S, Shearman CW. Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency. Am J Physiol Renal Physiol 292(2):F789-F795, 2007. e-Pub 2007. PMID: 17018845.
- Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol 291(5):F995-F1004, 2006. e-Pub 2006. PMID: 16774905.
- Sung SH, Ziyadeh FN, Wang A, Pyagay PE, Kanwar YS, Chen S. Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. J Am Soc Nephrol 17(11):3093-3104, 2006. e-Pub 2006. PMID: 16988063.
- Wysocki J, Ye M, Soler MJ, Gurley SB, Xiao HD, Bernstein KE, Coffman TM, Chen S, Batlle D. ACE and ACE2 activity in diabetic mice. Diabetes 55(7):2132-2139, 2006. e-Pub 2006. PMID: 16804085.
- Cohen MP, Chen S, Ziyadeh FN, Shea E, Hud EA, Lautenslager GT, Shearman CW. Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. Kidney Int 68(4):1554-1561, 2005. e-Pub 2005. PMID: 16164632.
- Chen S, Lee JS, Iglesias-de la Cruz MC, Wang A, Izquierdo-Lahuerta A, Gandhi NK, Danesh FR, Wolf G, Ziyadeh FN. Angiotensin II stimulates α3(IV) collagen production in mouse podocytes via TGF-β and VEGF signalling: Implications for diabetic glomerulopathy. Nephrol Dial Transplant 20(7):1320-1328, 2005. e-Pub 2005. PMID: 15840669.
- Chen S, Kasama Y, Lee JS, Jim B, Marin M, Ziyadeh FN. Podocyte-derived vascular endothelial growth factor mediates the stimulation of α3(IV) collagen production by transforming growth factor-β1 in mouse podocytes. Diabetes 53(11):2939-2949, 2004. e-Pub 2004. PMID: 15504975.
- Chen S, Hoffman BB, Lee JS, Kasama Y, Jim B, Kopp JB, Ziyadeh FN. Cultured tubule cells from TGF-β1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Kidney Int 65(4):1191-1204, 2004. e-Pub 2004. PMID: 15086458.
- Moreno-Manzano V, Mampaso F, Sepúlveda-Muñoz JC, Alique M, Chen S, Ziyadeh FN, Iglesias-de la Cruz MC, Rodríguez J, Nieto E, Orellana JM, Reyes P, Arribas I, Xu Q, Kitamura M, Lucio Cazana FJ. Retinoids as a potential treatment for experimental puromycin-induced nephrosis. Br J Pharmacol 139(4):823-831, 2003. e-Pub 2003. PMID: 12813006.
- Cohen MP, Shea E, Chen S, Shearman CW. Glycated albumin increases oxidative stress, activates NF-κB and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-β1 production in macrophage RAW cells. J Lab Clin Med 141(4):242-249, 2003. e-Pub 2003. PMID: 12677169.
- Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN. Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice. Biochem Biophys Res Commun 300(1):16-22, 2003. e-Pub 2003. PMID: 12480514.
- Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem Biophys Res Commun 296(5):1356-1365, 2002. e-Pub 2002. PMID: 12207925.
- Iglesias-de la Cruz MC, Ziyadeh FN, Isono M, Kouahou M, Han DC, Kalluri R, Mundel P, Chen S. Effects of high glucose and TGF-β1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int 62(3):901-913, 2002. e-Pub 2002. PMID: 12164872.
- Cohen MP, Ziyadeh FN, Hong SW, Shearman CW, Hud E, Lautenslager GT, Iglesias-de la Cruz MC, Chen S. Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-β1. Kidney Int 61(6):2025-2032, 2002. e-Pub 2002. PMID: 12028443.
- Hong SW, Isono M, Chen S, Iglesias-de la Cruz MC, Han DC, Ziyadeh FN. Increased glomerular and tubular expression of transforming growth factor-β1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 158(5):1653-1663, 2001. e-Pub 2001. PMID: 11337363.
- Han DC, Isono M, Chen S, Casaretto A, Hong SW, Wolf G, Ziyadeh FN. Leptin stimulates type I collagen production in db/db mesangial cells: Glucose uptake and TGF-β type II receptor expression. Kidney Int 59(4):1315-23, 2001. e-Pub 2001. PMID: 11260392.
- Chen S, Cohen MP, Lautenslager GT, Shearman CW, Ziyadeh FN. Glycated albumin stimulates TGF-β1 production and protein kinase C activity in glomerular endothelial cells. Kidney Int 59(2):673-681, 2001. e-Pub 2001. PMID: 11168949.
- Iglesias-de la Cruz MC, Ruiz-Torres P, Alcamí J, Díez-Marqués L, Ortega-Velázquez R, Chen S, Rodríguez-Puyol M, Ziyadeh FN, Rodríguez-Puyol D. Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells. Kidney Int 59(1):87-95, 2001. e-Pub 2001. PMID: 11135061.
- Isono M, Cruz MC, Chen S, Hong SW, Ziyadeh FN. Extracellular signal-regulated kinase mediates stimulation of TGF-β1 and matrix by high glucose in mesangial cells. J Am Soc Nephrol 11(12):2222-2230, 2000. e-Pub 2000. PMID: 11095645.
- Ziyadeh FN, Hoffman BB, Han DC, Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice. Proc Natl Acad Sci U S A 97(14):8015-8020, 2000. e-Pub 2000. PMID: 10859350.
Invited Articles
- Perazella MA, Workeneh B, Chen S. Evolution of the kidney-cancer connection. Journal of Onco-Nephrology 3(2):88-91, 2019. e-Pub 2019.
- Chen S. Hyponatremia in cancer patients: Strategy for safe correction in the hospital. Journal of Onco-Nephrology 3(3):144-150, 2019. e-Pub 2019.
- Chen S. Kinetic GFR in routine clinical practice-Applications and possibilities. Adv Chronic Kidney Dis 25(1):105-114, 2018. e-Pub 2018. PMID: 29499881.
- Kanwar YS, Sun L, Xie P, Liu FY, Chen S. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol 6:395-423, 2011. e-Pub 2011. PMID: 21261520.
- Brosius FC, Khoury CC, Buller CL, Chen S. Abnormalities in signaling pathways in diabetic nephropathy. Expert Rev Endocrinol Metab 5(1):51-64, 2010. e-Pub 2010. PMID: 20224802.
- Chen S, Ziyadeh FN. Vascular endothelial growth factor and diabetic nephropathy. Curr Diab Rep 8(6):470-476, 2008. e-Pub 2008. PMID: 18990304.
- Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR. Diabetic nephropathy: Mechanisms of renal disease progression. Exp Biol Med (Maywood) 233(1):4-11, 2008. e-Pub 2008. PMID: 18156300.
- Chen S, Jalandhara N, Batlle D. Evaluation and management of hyponatremia: An emerging role for vasopressin receptor antagonists. Nat Clin Pract Nephrol 3(2):82-95, 2007. e-Pub 2007. PMID: 17251996.
- Cohen MP, Ziyadeh FN, Chen S. Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: Pathogenic and therapeutic implications. J Lab Clin Med 147(5):211-219, 2006. e-Pub 2006. PMID: 16697768.
- Chen S, Jim B, Ziyadeh FN. Diabetic nephropathy and transforming growth factor-β: Transforming our view on glomerulosclerosis and fibrosis buildup. Semin Nephrol 23(6):532-543, 2003. e-Pub 2003. PMID: 14631561.
- Iglesias-de la Cruz MC, Chen S, Ziyadeh FN, Pancorbo-Alonso, MA. Patogénesis de la nefropatía diabética. Ciencia Al Día Internacional 5(1), 2003. e-Pub 2003.
- Ziyadeh FN, Isono M, Chen S. Involvement of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy. Clin Exp Nephrol 6(3):125-129, 2002. e-Pub 2002. PMID: 24989950.
- Wolf G, Chen S, Han DC, Ziyadeh FN. Leptin and renal disease. Am J Kidney Dis 39(1):1-11, 2002. e-Pub 2002. PMID: 11774095.
- Chen S, Wolf G, Ziyadeh FN. The renin-angiotensin system in diabetic nephropathy. Contributions to Nephrology 135:212-221, 2001. e-Pub 2001. PMID: 11705286.
- Chen S, Cohen MP, Ziyadeh FN. Amadori-glycated albumin in diabetic nephropathy: Pathophysiologic connections. Kidney Int Suppl 58:S40-S44, 2000. e-Pub 2000. PMID: 10997689.
- Chen S, Casaretto A, Ziyadeh FN. Pathogenesis of diabetic nephropathy. Science & Medicine 7:10-19, 2000. e-Pub 2000.
Review Articles
- Chen S, Chiaramonte R. Estimating Creatinine Clearance in the Nonsteady State: The Determination and Role of the True Average Creatinine Concentration. Kidney Med 1(4):207-216, 2019. e-Pub 2019. PMID: 32734201.
- Chung CH, Fan J, Lee EY, Kang JS, Lee SJ, Pyagay PE, Khoury CC, Yeo TK, Khayat MF, Wang A, Chen S. Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy. Nephron EXTRA 5(1):1-18, 2015. e-Pub 2015. PMID: 25852733.
- Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy. Diabetes 54(6):1626-1634, 2005. e-Pub 2005. PMID: 15919782.
- Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A, Ziyadeh FN. The key role of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy. Ren Fail 23(3-4):471-481, 2001. e-Pub 2001. PMID: 11499562.
- Furst H, Hallows KR, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. The urine/plasma electrolyte ratio: A predictive guide to water restriction. Am J Med Sci 319(4):240-244, 2000. e-Pub 2000. PMID: 10768609.
Professional Educational Materials
- Chen S, Goldfarb S. Diabetic Nephropathy: Nephrology Board Review Manual. Hospital Physician, 2001.
- Chen S, Ziyadeh FN. Hypertension: Physician Education Material (University of Pennsylvania Intranet), 2000.
Other Articles
- Chen S, Jalandhara N, Batlle D Erratum: Evaluation and management of hyponatremia: An emerging role for vasopressin receptor antagonists. Nat Clin Pract Nephrol 3:233, 2007.
Abstracts
- Chen S, Mandayam S, Workeneh B. Rare Case of Dual Paraneoplastic Syndromes from Small Cell Lung Cancer Causing a Triphasic Electrolyte Presentation. World Congress of Nephrology, 2026. e-Pub 2026.
- Tefera M, Tchakarov A, Mandayam S, Chen S, Workeneh B. When the Congo Red Still Glows: Distinguishing Old From New Amyloid in Treated AL Disease. World Congress of Nephrology, 2026. e-Pub 2026.
- Youssef N, Tran J, Nuh M, Workeneh B, Mandayam SA, Chen S. Rare Case of Dual Paraneoplastic Endocrinopathies in Small Cell Lung Cancer: Triphasic Electrolyte Presentation. American Society of Nephrology, 2025. e-Pub 2025.
- Youssef N, Tran J, Nuh M, Workeneh B, Mandayam SA, Chen S. Rare Case of Dual Paraneoplastic Endocrinopathies in Small Cell Lung Cancer: Triphasic Electrolyte Presentation. Onco-Nephrology Symposium, 2025. e-Pub 2025.
- Chen S. Rapid Diagnosis of Hypokalemia in the Setting of a Neuroendocrine Tumor. Poster presented at the American Society of Onco-Nephrology meeting, New York, NY, 2024. e-Pub 2024.
- Chen S. Avoiding the Paradoxical Worsening of Hyponatremia in SIADH. Poster presented at the American Society of Onco-Nephrology meeting, Boston, MA, 2022. e-Pub 2022.
- Polani AS, Reddy VD, Mukku VK, Parvathareddy V, Chen S. A Rare Cause of Hyponatremia: Renal Salt Wasting Syndrome of Unclear Etiology Post Autologous Hematopoietic Stem Cell Transplant. Poster presented at the 54th Annual American Society of Nephrology meeting, San Diego, CA, 2021. e-Pub 2021.
- Parvathareddy V, Mukku VK, Polani AS, Chen S. Utility of liquid chromatography in monitoring methotrexate level after Glucarpidase for Methotrexate toxicity. Poster presented at the 54th Annual American Society of Nephrology meeting, San Diego, CA, 2021. e-Pub 2021.
- Chen S. How to Estimate Kidney Function in AKI via the Basic Clearance: Role of the True Average [Creatinine]. Poster presented at the 52nd Annual American Society of Nephrology meeting, Washington, DC, 2019. e-Pub 2019.
- Abudayyeh A, Kalu CO, Lakhani LS, Workeneh B, Lahoti A, Chen S, Danesh FR, Abdelrahim M. Incidence of AKI in a Large Retrospective Cancer Cohort Using Checkpoint Inhibitors. 51st Annual American Society of Nephrology, San Diego, CA, 2018. e-Pub 2018.
- Chen S. Improving the Kinetic GFR by Taking Volume Changes into Account. Poster presented at the 51st Annual American Society of Nephrology meeting, San Diego, CA, 2018. e-Pub 2018.
- Kwong YD, Chen S, Liu KD. Impact of Kinetic Glomerular Filtration Rate Estimation on Medication Dosing in AKI. Oral Communication presented at the 51st Annual American Society of Nephrology meeting, San Diego, CA, 2018. e-Pub 2018.
- Chen S. New Sodium Equation with Built-In Rate of Correction to Simplify Therapeutic Orders for Hyponatremia or Hypernatremia. Poster presented at the 50th Annual American Society of Nephrology meeting, New Orleans, LA, 2017. e-Pub 2017.
- Safdi A, Ahya SN, Kanwar YS, Chen SC. Horsetail Tea Ingestion and End-Stage Renal Disease: An Unrecognized Form of Silica Associated Nephropathy?. Poster presented at the 46th Annual American Society of Nephrology meeting, Atlanta, GA, 2013. e-Pub 2013.
- Martínez García C, Yeo TK, Vivas García Y, Izquierdo Lahuerta A, Chen S, Medina-Gómez G. Study of lipotoxicity mechanisms of Palmitic acid in murine podocytes. Presented at the 55th Congress of Nutrition and Endocrinology Spanish Society, 2013. e-Pub 2013.
- Chen S. Retooling the creatinine clearance equation to estimate kidney function when the serum creatinine is changing acutely: Kinetic eGFR formula. Poster presented at the 45th Annual American Society of Nephrology meeting, San Diego, CA, 2012. e-Pub 2012.
- Khayat MF, Khoury CC, Yeo TK, Pyagay P, Yu W, Chen SC. Intravital Multiphoton Imaging of Mouse Podocytes. Oral Communication talk at the 44th Annual American Society of Nephrology meeting, Philadelphia, PA, 2011. e-Pub 2011.
- Yeo TK, Chen S. Snail and Zeb2: A transcription factor tag team in podocyte plasticity. Poster presented at the Lewis Landsberg Research Day, Northwestern University, 2011. e-Pub 2011.
- Khoury CC, Chen S. Looking at the podocyte through a new lens: Multiphoton microscopy of the mouse glomerulus. Poster presented at the Lewis Landsberg Research Day, Northwestern University, 2011. e-Pub 2011.
- Fan J, Chung CH, Lee EY, Pyagay P, Wang A, Chen SC. TNF-α affects podocyte expression of collagen IV and integrin α3: Role of PI3K and MCP-1. Poster presented at the 43rd Annual American Society of Nephrology meeting, Denver, CO, 2010. e-Pub 2010.
- Yeo TK, Khoury CC, Chen SC. Can podocytes undergo epithelial-to-mesenchymal transition?. Poster presented at the 43rd Annual American Society of Nephrology meeting, Denver, CO, 2010. e-Pub 2010.
- Yeo TK, Khoury CC, Lee EY, Pyagay PE, Chang A, Wang A, Chen S. Beyond inflammation: The effect of CCR2-knockout (KO) on diabetic nephropathy and albuminuria. Oral Communication talk at the 42nd Annual American Society of Nephrology meeting, 2009. e-Pub 2009.
- Lee EY, Chung CH, Pyagay P, Wang A, Chen S. The pleiotropic effects of monocyte chemoattractant protein-1 increase podocyte motility and albumin permeability: Evidence for a podocytic MCP-1 autocrine loop in diabetes. Poster presented at the 41st Annual American Society of Nephrology meeting, Philadelphia, PA, 2008. e-Pub 2008.
- Lee EY, Chung CH, Wang A, Pyagay P, Chen S. The TGF-β-stimulated production of monocyte chemoattractant protein (MCP)-1 by podocytes influences podocyte motility and permeability: Evidence for an MCP-1 autocrine loop. Poster presented at the 2008 Annual Meeting of the Central Society for Clinical Research (CSCR), Chicago, IL, 2008. e-Pub 2008.
- Lee EY, Chung CH, Wang A, Pyagay P, Chen S. Podocyte-derived monocyte chemoattractant protein (MCP)-1 is stimulated by TGF-β and might contribute to diabetic nephropathy. Poster presented at the 40th Annual American Society of Nephrology meeting, San Francisco, CA, 2007. e-Pub 2007.
- Chen S, Wang A, Pyagay P, Kanwar YS, Ziyadeh FN. VEGF signaling blockade ameliorates diabetic albuminuria in mice: Effects on the kidney podocyte. Poster presented at the 2007 Annual Meeting of the Central Society for Clinical Research (CSCR), Chicago, IL, 2007. e-Pub 2007.
- Wang A, Pyagay P, Chen S. Paradoxical nephrin dysregulation in the db/db mouse model of diabetic nephropathy. Poster presented at the 39th Annual American Society of Nephrology meeting, San Diego, CA, 2006. e-Pub 2006.
- Chen S, Sung SH, Laping NJ, Ziyadeh FN. Blockade of VEGF Signaling, But Not Knockout of TGF-β/Smad3 Signaling, Ameliorates Diabetic Albuminuria in Mice, Possibly Via Effects on Nephrin. Poster presented at the 38th Annual American Society of Nephrology meeting, Philadelphia, PA, 2005. e-Pub 2005.
- Chen S, Sung SH, Laping NJ, Ziyadeh FN. VEGF signaling, but not Smad3 signaling, engenders albuminuria in diabetic nephropathy, possibly via alterations in nephrin expression. Oral Communication invited at the World Congress of Nephrology meeting, Singapore, 2005. e-Pub 2005.
- Chen S, Lee J, Kasama Y, Marin M, Ziyadeh FN, Sung SH. TGF-β1 stimulation of α3(IV) collagen production in mouse podocytes is partly mediated by a VEGF autocrine loop involving PI3K and PKC. Oral Communication presented at the 37th Annual American Society of Nephrology meeting, St. Louis, MO, 2004. e-Pub 2004.
- Sung SH, Chen S, Laping NJ, Ziyadeh FN. Albuminuria is ameliorated by an inhibitor of VEGF receptors, SU5416, in diabetic db/db mice but is unaffected in Smad3-knockout mice rendered diabetic with streptozotocin. Poster presented at the 37th Annual American Society of Nephrology meeting, St. Louis, MO, 2004. e-Pub 2004.
- Chen S, Lee JS, Hoffman BB, Ziyadeh FN. Cultured tubule cells from TGF-β1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Poster presented at the 36th Annual American Society of Nephrology meeting, San Diego, CA, 2003. e-Pub 2003.
- Chen S, Kasama Y, Lee JS, Jim B, Ziyadeh FN. VEGF stimulates the production of collagen IV by mouse podocytes in an autocrine loop. Oral Communication presented at the 36th Annual American Society of Nephrology meeting, San Diego, CA, 2003. e-Pub 2003.
- Chen S, Hong SW, Jim B, Lee JS, Kouahou M, Ziyadeh FN. Metabolic mediators of transforming growth factor-β activation in mouse podocytes. Oral Communication presented at the World Congress of Nephrology 2003 meeting, Berlin, Germany, 2003. e-Pub 2003.
- Chen S, Iglesias-de la Cruz MC, Kouahou M, Ziyadeh FN. The TGF-β system mediates some of the high glucose effects on differentiated mouse podocytes. Poster presented at the 35th Annual American Society of Nephrology meeting, Philadelphia, PA, 2002. e-Pub 2002.
- Chen S, Iglesias-de la Cruz MC, Ziyadeh FN, Mundel P. High glucose and TGF-β1 affect mouse podocyte expression of collagen IV and VEGF in similar and disparate ways. Presented at the University of Pennsylvania Department of Medicine Research Day, Philadelphia, PA, 2002. e-Pub 2002.
- Ziyadeh FN, Iglesias-de la Cruz MC, Hong SW, Isono M, Chen S. Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in db/db mice. Poster presented at the 34th Annual American Society of Nephrology meeting, San Francisco, CA, 2001. e-Pub 2001.
- Isono M, Chen S, Iglesias-de la Cruz MC, Hong SW, Ziyadeh FN. Activation of renal Smad signaling pathway in diabetic mice and regulation of fibronectin expression in mesangial cells cultured in high glucose. Poster presented at the 34th Annual American Society of Nephrology meeting, San Francisco, CA, 2001. e-Pub 2001.
- Iglesias-de la Cruz MC, Chen S, Isono M, Mundel P, Ziyadeh FN. Disparate effects of high glucose and TGF-β1 on type IV collagen expression in cultured mouse podocytes. Poster presented at the 34th Annual American Society of Nephrology meeting, San Francisco, CA, 2001. e-Pub 2001.
- Chen S, Cohen MP, Ziyadeh FN. Glycated albumin stimulates PKC activity and TGF-β1 production in glomerular endothelial cells. Poster presented at the 33rd Annual American Society of Nephrology meeting, Toronto, Canada, 2000. e-Pub 2000.
- Iglesias-de la Cruz C, Chen S, Wolf G, Mundel P, Ziyadeh FN. High glucose and angiotensin II stimulate TGF-β type II receptor and α5(IV) collagen expression in cultured mouse podocytes. Oral communication presented at the 33rd Annual American Society of Nephrology meeting, Toronto, Canada, 2000. e-Pub 2000.
- Han DC, Chen S, Hong SW, Iglesias de la Cruz MC, Ziyadeh FN. Increased expression of TGF-β1, VEGF, and fibronectin in rat glomerular endothelial cells by high ambient glucose. Poster presented at the 32nd Annual American Society of Nephrology meeting, Miami Beach, FL, 1999. e-Pub 1999.
- Chen S, Lee BJ, Guo J, Post JB, Gehret JA, Danoff TM, Ziyadeh FN. Anti-TGF-β antibody treatment ameliorates fibrosis in unilateral ureteral obstruction. Poster presented at the 32nd Annual American Society of Nephrology meeting, Miami Beach, FL, 1999. e-Pub 1999.
- Cohen MP, Chen S, Ziyadeh FN. Glycated albumin (GA) modulates glomerular endothelial cell biology. Abstract for American Diabetes Association 59th Scientific Session, 1999. e-Pub 1999.
- Chen S, Guo J, Cohen JA, Cohen MP, Ziyadeh FN. Amadori-modified albumin increases extracellular matrix mRNA and protein levels by stimulating PKC signaling and the TGF-β system in cultured mouse mesangial cells. XVth International Congress of Nephrology, Buenos Aires, Argentina, 1999. e-Pub 1999.
Book Chapters
- Yaeh A, Chen S. Renal Failure: Acute, Acute on Chronic, Prevention. In: Oncology Hospital Medicine: A Guide for the Frontline Clinician. 1st. Springer Nature, 2026.
- Chen S, Khoury C, Ziyadeh FN. Pathophysiology and pathogenesis of diabetic nephropathy. In: Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology. 6th. Elsevier, 2025.
- Batlle D, Chen S, Haque SK. Physiologic principles in the clinical evaluation of electrolyte, water, and acid-base disorders. In: Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology. 6th. Elsevier, 2025.
- Khoury CC, Chen S, Ziyadeh FN. Mechanisms of Diabetic Nephropathy in Humans and Experimental Animals. In: Blood Pressure Disorders in Diabetes Mellitus. 1st edition. Springer Nature, 129-151, 2023.
- Lahoti A, Chen S. Acute Kidney Injury: Incidence, Pathogenesis, and Outcomes. In: Onco-Nephrology. 1st edition. Elsevier, 270-274, 2020.
- Khoury CC, Chen S, Ziyadeh FN. Pathophysiology of Diabetic Kidney Disease. In: Chronic Renal Disease. 2nd edition. Elsevier, 279-296, 2019.
- Khoury CC, Chen S, Ziyadeh FN. Pathophysiology of Diabetic Nephropathy. In: Chronic Renal Disease. 1st edition. Elsevier, 151-162, 2014.
- Batlle D, Chen S, Haque SK. Physiologic principles in the clinical evaluation of electrolyte, water, and acid-base disorders. In: Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology. 5th edition. Elsevier, 2477-2511, 2013.
- Chen S, Khoury C, Ziyadeh FN. Pathophysiology and pathogenesis of diabetic nephropathy. In: Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology. 5th edition. Elsevier, 2605-2632, 2013.
- Chen S, Ziyadeh FN. Transforming Growth Factor-β signal transduction in the pathogenesis of diabetic nephropathy: Identifying molecular targets for therapeutic intervention. In: Contemporary Diabetes: The Diabetic Kidney. 1st edition. The Humana Press, 201-221, 2006.
- Jim B, Chen S, Ziyadeh FN. Transforming growth factor-β and other cytokines in experimental and human diabetic nephropathy. In: The Kidney and Hypertension in Diabetes Mellitus. 1st edition. Taylor & Francis Group, 397-432, 2004.
- Chen S, Iglesias-de la Cruz MC, Isono M, Ziyadeh FN. Transforming growth factor-β and other cytokines in experimental and human diabetic nephropathy. In: The Kidney and Hypertension in Diabetes Mellitus. 5th edition. Kluwer Academic Publishers, 313-338, 2000.
Letters to the Editor
- Chen S, Shey J. Response to "Kinetic sodium equation". Journal of Onco-Nephrology 2: 33-34, 2018.
Patient Reviews
CV information above last modified March 07, 2026