Shih-Han Lee, Ph.D.
Department of Genetics, Division of VP, Research
About Dr. Shih-Han Lee
Dr. Lee received her bachelor’s and master’s degrees from National Taiwan University in Taiwan, and then her doctoral degree from the University of Nottingham in the UK. She undertook her postdoctoral training at Memorial Sloan Kettering Cancer Center, where she pursued the role of alterations on the RNA level in cancer. Her work unraveled how cancer cells employ RNA processing to manipulate gene expression and alter protein functions to promote cell survival. Using multidisciplinary approaches including genetic, molecular biology, biochemistry and RNA cancer biology, her lab at MD Anderson Cancer Center focuses on understanding the principles of how transcriptomic drivers impact cancer pathogenesis and how the expression of transcript variants is regulated.
Present Title & Affiliation
Assistant Professor, Department of Genetics, Division of Basic Science Research, MD Anderson Cancer Center, Houston, TX
Education & Training
|2009||University of Nottingham, Nottingham, GBR, PHD, Stem Cell Biology and Genetics|
|2002||National Taiwan University, Taipei, TWN, MSc, Plant Molecular Biology|
|2000||National Taiwan University, Taipei, TWN, BSc, Horticulture|
|2012-2021||Research Fellow, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY|
|2010-2012||Postdoctoral Research Associate, University College London (UCL), London|
Experience & Service
Research Assistant, National Taiwan University Hospital, Taipei, 2004 - 2005
Head of Molecular Biology Division, Abnova Corporation, Taipei, 2002 - 2004
Honors & Awards
|2019||The Ophelia Branca Snyder Society Scholar Prize, Memorial Sloan Kettering Cancer Center|
|2018||Postdoctoral Research Symposium, Memorial Sloan Kettering Cancer Center|
|1999||National Taiwan University Presidential Award|
- Lee SH, Mayr C. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Mol Cell 74(4):701-712.e9, 2019. e-Pub 2019. PMID: 30948266.
- Lee SH, Singh I, Tisdale S, Abdel-Wahab O, Leslie CS, Mayr C. Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. Nature 561(7721):127-131, 2018. e-Pub 2018. PMID: 30150773.
- Singh I, Lee SH, Sperling AS, Samur MK, Tai YT, Fulciniti M, Munshi NC, Mayr C, Leslie CS. Widespread intronic polyadenylation diversifies immune cell transcriptomes. Nat Commun 9(1):1716, 2018. e-Pub 2018. PMID: 29712909.
- Teschendorff AE, Lee SH, Jones A, Fiegl H, Kalwa M, Wagner W, Chindera K, Evans I, Dubeau L, Orjalo A, Horlings HM, Niederreiter L, Kaser A, Yang W, Goode EL, Fridley BL, Jenner RG, Berns EM, Wik E, Salvesen HB, Wisman GB, van der Zee AG, Davidson B, Trope CG, Lambrechts S, Vergote I, Calvert H, Jacobs IJ, Widschwendter M. HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Genome Med 7:108, 2015. e-Pub 2015. PMID: 26497652.
- Jones A, Teschendorff AE, Li Q, Hayward JD, Kannan A, Mould T, West J, Zikan M, Cibula D, Fiegl H, Lee SH, Wik E, Hadwin R, Arora R, Lemech C, Turunen H, Pakarinen P, Jacobs IJ, Salvesen HB, Bagchi MK, Bagchi IC, Widschwendter M. Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. PLoS Med 10(11):e1001551, 2013. e-Pub 2013. PMID: 24265601.
- Kwon, B, Fansler, M M, Patel, N, Lee, S.-H, Lee, J, Ma, W, Mayr, C. Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms. BioRxiv, 2021.