Shivanand Pudakalakatti, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Instructor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Instructor, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2015 | Indian Institute of Science, Bangalore, IN, Chemistry, Ph.D |
| 2009 | Karnatak University, Dharwad, IN, Chemistry, M.S |
| 2007 | Karnatak Science College, Dharwad, US, Chemistry, Physics, and Mathematics, BS |
Postgraduate Training
| 2016-2021 | Research Fellowship, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Academic Appointments
Research Investigator, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2021 - 2023
Postdoctoral Research Fellow, Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2021
Institutional Committee Activities
Member, Metabolism in Cancer Symposium Committee, 2024 - 2024
Vice-Chair, Annual Postdoctoral Career Symposium (APCS), 2019 - 2019
Vice-Chair, Annual Postdoctoral Career Symposium (APCS), 2018 - 2018
Member, Postdoctoral Association Executive Committee (PDAEC), 2017 - 2017
Honors & Awards
| 2019 | Postdoctoral Travel Award, MD Anderson Cancer Center |
| 2018 | Summa Cum Laude (Gold) Merit Award, 26th Joint Annual Meeting ISMRM-ESMRMB |
| 2018 | AACR Scholar-in-Training Awards, AACR |
| 2017 | Trainee travel award, at Division of Diagnostic Imaging Annual Trainee Symposium at MD Anderson Cancer Center |
| 2014 | Ernst-Wuthrich Travel Award, Bruker Biospin |
| 2009 | Second Prize, the Department of Science and Technology, Government of Karnataka |
| 2007 | First Prize, Kittel Science College Dharwad |
| 1999 | National Merit scholarship (Rural Students), Government of India |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Tran RL, Li T, de la Cerda J, Schuler FW, Khaled AS, Pudakalakatti S, Bhattacharya PK, Sinharay S, Pagel MD. Potentiation of immune checkpoint blockade with a pH-sensitizer as monitored in two pre-clinical tumor models with acidoCEST MRI. Br J Cancer. e-Pub 2025. PMID: 39994445.
- McCowan CV, Salmon D, Hu J, Pudakalakatti S, Whiting N, Davis JS, Carson DD, Zacharias NM, Bhattacharya PK, Farach-Carson MC. Post-Acquisition Hyperpolarized 29Silicon Magnetic Resonance Image Processing for Visualization of Colorectal Lesions Using a User-Friendly Graphical Interface. Diagnostics (Basel) 12(3), 2022. e-Pub 2022. PMID: 35328163.
- Tripathi S, Park JH, Pudakalakatti S, Bhattacharya PK, Kaipparettu BA, Levine H. A mechanistic modeling framework reveals the key principles underlying tumor metabolism. PLoS Comput Biol 18(2):e1009841, 2022. e-Pub 2022. PMID: 35148308.
- Pudakalakatti S, Titus M, Enriquez JS, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci 23(3), 2022. e-Pub 2022. PMID: 35163565.
- Kim J, Jo D, Yang SH, Joo CG, Whiting N, Pudakalakatti S, Seo H, Son HY, Min SJ, Bhattacharya P, Huh YM, Shim JH, Lee Y. 29Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe. ACS Appl Mater Interfaces 13(48):56923-56930, 2021. e-Pub 2021. PMID: 34793118.
- Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI) 4(4), 2021. e-Pub 2021. PMID: 35937580.
- Jaiswal AR, Liu AJ, Pudakalakatti S, Dutta P, Jayaprakash P, Bartkowiak T, Ager CR, Wang ZQ, Reuben A, Cooper ZA, Ivan C, Ju Z, Nwajei F, Wang J, Davies MA, Davis RE, Wargo JA, Bhattacharya PK, Hong DS, Curran MA. Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype. Cancer Immunol Res 8(11):1365-1380, 2020. e-Pub 2020. PMID: 32917656.
- Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW. Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy. Angew Chem Int Ed Engl 58(13):4179-4183, 2019. e-Pub 2019. PMID: 30680862.
- Seo H, Choi I, Whiting N, Hu J, Luu QS, Pudakalakatti S, McCowan C, Kim Y, Zacharias N, Lee S, Bhattacharya P, Lee Y. Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29 Si Magnetic Resonance Imaging. Chemphyschem 19(17):2143-2147, 2018. e-Pub 2018. PMID: 29779258.
- Uppangala S, D'Souza F, Pudakalakatti S, Atreya HS, Raval K, Kalthur G, Adiga SK. Laser assisted zona hatching does not lead to immediate impairment in human embryo quality and metabolism. Syst Biol Reprod Med 62(6):396-403, 2016. e-Pub 2016. PMID: 27598006.
- D'Souza F, Pudakalakatti SM, Uppangala S, Honguntikar S, Salian SR, Kalthur G, Pasricha R, Appajigowda D, Atreya HS, Adiga SK. Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos. Sci Rep 6:37291, 2016. e-Pub 2016. PMID: 27853269.
- Uppangala S, Pudakalakatti S, D'souza F, Salian SR, Kalthur G, Kumar P, Atreya H, Adiga SK. Influence of sperm DNA damage on human preimplantation embryo metabolism. Reprod Biol 16(3):234-241, 2016. e-Pub 2016. PMID: 27492188.
- Venkateshaa N, Pudakalakattib SM, Qurishic Y, Atreyab HS, Srivastava C. MnFe2O4–Fe3O4 core–shell nanoparticles as a potential contrast agent for magnetic resonance imaging. Royal Society of Chemistry, 2015. e-Pub 2015.
- PUDAKALAKATTI SM, DUBEY A, ATREYA HS. Simultaneous acquisition of three NMR spectra in a single experiment for rapid resonance assignments in metabolomics. Journal of Chemical Sciences 127:1091-1097, 2015. e-Pub 2015.
- Pudakalakatti SM, Chandra K, Thirupathi R, Atreya HS. Rapid characterization of molecular diffusion by NMR spectroscopy. Chemistry 20(48):15719-22, 2014. e-Pub 2014. PMID: 25331210.
- Pudakalakatti SM, Dubey A, Jaipuria G, Shubhashree U, Adiga SK, Moskau D, Atreya HS. A fast NMR method for resonance assignments: application to metabolomics. J Biomol NMR 58(3):165-73, 2014. e-Pub 2014. PMID: 24488481.
- Pudakalakatti SM, Uppangala S, D'Souza F, Kalthur G, Kumar P, Adiga SK, Atreya HS. NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential. NMR Biomed 26(1):20-7, 2013. e-Pub 2013. PMID: 22714820.
Other Articles
- Sharma G, Enriquez JS, Armijo R, Wang M, Bhattacharya P, Pudakalakatti S Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-13C Pyruvate MRSI. Metabolites 13(5), 2023. PMID: 37233647.
- Pudakalakatti S, Chin R, Pagel MD, Bhattacharya PK Magnetic Resonance Techniques for Assessing in Vivo pH. Archives of Cancer Research and Medicine 2(1), 2022.
- Pudakalakatti S, Enriquez JS, McCowan C, Ramezani S, Davis JS, Zacharias NM, Bourgeois D, Constantinou PE, Harrington DA, Carson D, Farach-Carson MC, Bhattacharya PK Hyperpolarized MRI with silicon micro and nanoparticles: Principles and applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13(6):e1722, 2021. PMID: 33982426.
- Enriquez JS, Chu Y, Pudakalakatti S, Hsieh KL, Salmon D, Dutta P, Millward NZ, Lurie E, Millward S, McAllister F, Maitra A, Sen S, Killary A, Zhang J, Jiang X, Bhattacharya PK, Shams S Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer. JMIR Med Inform 9(6):e26601, 2021. PMID: 34137725.
- Joseph D, Sukumaran S, Chandra K, Pudakalakatti SM, Dubey A, Singh A, Atreya HS Rapid nuclear magnetic resonance data acquisition with improved resolution and sensitivity for high-throughput metabolomic analysis. Magn Reson Chem 59(3):300-314, 2021. PMID: 33030750.
- Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM, Bhattacharya PK Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4), 2019. PMID: 30978984.
Book Chapters
- Pudakalakatti S, Raj P, Salzillo TC, Florencia M, Titus M, Dutta P, et al. Cancer Immunoprevention: Methods and Protocols. In: Methods in Molecular Biology, 2022.
- Lin C, Salzillo TC, Bader DA, Wilkenfeld SR, Awad D, Pulliam TL, Dutta P, Pudakalakatti S, Titus M, McGuire SE, Bhattacharya PK, Frigo DE. Prostate Cancer Energetics and Biosynthesis. In: Prostate Cancer - Cellular and Genetic Mechanisms of Disease Development and Progression, 2019.
- Dubey A, Pudakalakatti S, Atreya HS. Fast NMR Methods for Identification of Resonances and Metabolic Pathways. In: NMR-Based Metabolomics, 135-137, 2019.
- Salzillo TC, Hu J, Nguyen L, Whiting N, Lee J, weygand J, Dutta P, Pudakalakatti S, et al. Interrogating metabolism in brain cancer. In: Magnetic Resonance Imaging Clinics of North America, 2016.
Selected Presentations & Talks
Local Presentations
- 2024. Identifying Non-Invasive Biomarkers for Prognosis of Renal Cell Carcinoma Using NMR Spectroscopy. Conference. MD Anderson Summer Program Symposium. Houston, TX, US.
- 2024. Unraveling Metabolic Changes in Melanoma Tumors of Exercising and Non-Exercising Mice. Conference. MD Anderson Summer Program Symposium. Hosuton, TX, US.
- 2018. Identifying immunotherapy resistance in vitro and in vivo by magnetic resonance (. Conference. GCC NMR and Cell Tracking Symposium, Rice University. Houston, TX, US.
- 2017. Identifying immunotherapy resistance in melanoma in vitro and in vivo by Magnetic Resonance. Conference. Division of Diagnostic Imaging, University of Texas. Houston, TX, US.
- 2017. Early detection of pancreatic cancer by targeted molecular MRI Imaging of hyperpolarized silicon nanoparticles. Conference. Keck Annual Symposium. Houston, TX, US.
Regional Presentations
- 2017. Molecular targeting of MUC1 in colorectal cancer using hyperpolarized magnetic resonance imaging of silicon particles. Conference. Cancer Prevention and Research Institute of Texas Conference. Austin, TX, US.
National Presentations
- 2022. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Conference. 63rd Experimental Nuclear Magnetic Resonance Conference. Orlando, FL, US.
- 2018. Imaging immunotherapy resistance in melanoma in vitro and in vivo employing magnetic resonance. Conference. Third AACR-SNMMI Joint Conference State-of-Art Molecular imaging in Cancer Biology and Therapy. San Diego, CA, US.
- 2017. Unique Molecular Signatures to Distinguish Immunotherapy Responding and Resistant Melanoma by Magnetic Resonance. Invited. Hyperpolarized study section, International Society for Magnetic Resonance in Medicine (ISMRM). Honolulu, HI, US.
- 2014. New fast NMR Methods for accelerating data acquisition and analysis in Metabolomics. Conference. 55th Experimental Nuclear Magnetic Resonance. Boston, MA, US.
International Presentations
- 2024. Enhancing Immunotherapy Sensitivity in Resistant Melanoma and Early Prediction of Treatment Efficacy Using Hyperpolarized and acidoCEST MRI. Conference. World Molecular Imaging Conference. Montreal, CA.
- 2024. Sensitizing immunotherapy resistant melanoma into responsive and interrogating the transformation by hyperpolarized and acidoCEST MR. Conference. European Molecular Imaging Conference. Porto, PT.
- 2021. Application of hyperpolarized magnetic resonance (MR) to therapeutic intervention of melanoma and targeted molecular imaging of colorectal cancer. Invited. Department of studies in Chemistry, Karnataka University. Dharwad, IN.
- 2019. Identifying immunotherapy resistance in melanoma in vivo and in vitro employing magnetic resonance imaging and spectroscopy. Conference. World Molecular Imaging Congress. Montreal, CA.
- 2018. NMR spectroscopy-based blood test to diagnose brain cancer at early stages. Invited. International Society for Magnetic Resonance in Medicine (ISMRM). Paris, FR.
- 2017. Unique molecular signatures to distinguish immunotherapy responding and resistant cell lines in melanoma by NMR spectroscopy and MR hyperpolarization. Conference. Asia-Pacific NMRS. Bangalore, IN.
- 2014. Accelerating 3D HSQC-DOSY with projection NMR spectroscopy and non-uniform sampling (. Conference. NMRS India Conference, Tezpur University. Assam, IN.
- 2012. NMR and Metabolomics: Application to Human In Vitro Fertilization. Conference. 18th NMRS India conference. Bangalore, IN.
Grant & Contract Support
| Date: | 2025 - 2028 |
| Title: | Targeting MCTs to overcome Immunotherapy Resistance in Melanoma |
| Funding Source: | MRA |
| Role: | PI |
| Date: | 2025 - 2028 |
| Title: | Sensitizing high grade serous ovarian cancer to immunotherapy |
| Funding Source: | Ovarian Cancer Research Alliance (OCRA) |
| Role: | PI |
| ID: | ECIG-2025-3-2055 |
| Date: | 2024 - 2027 |
| Title: | Development of novel startergies to revert immunotherapy resistance in melanoma |
| Funding Source: | Melanoma Research Alliance |
| Role: | Principal Investigator-MDACC |
| Date: | 2024 - 2024 |
| Title: | Development of platelet-based metabolic biomarkers for early detection and regression of early-stage pancreatic cancer by immunopreventive intervention |
| Funding Source: | Elsa U. Pardee Foundation |
| Role: | PI |
| ID: | FP00020484 |
| Date: | 2023 - 2024 |
| Title: | Fuel for the Fire: New Approaches to Imaging Pancreatic Cancer Metabolism |
| Funding Source: | American Pancreatic Association Foundation |
| Role: | PI |
| Title: | Gulf Coast Consortia, Cancer Prevention & Research Institute of Texas (CPRIT) Computational Cancer Biology Training Program (CCBTP) |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Postdoctoral Fellow |
| ID: | RP1700593 |
Patient Reviews
CV information above last modified April 02, 2025