Shunbin Xiong
Department of Genetics, Division of Basic Sciences
About Dr. Xiong
Dr. Xiong’s research focus is to investigate p53 pathway using genetically modified mouse models. Tumor suppressor gene p53 is often mutated or inhibited by its negative regulators, Mdm2 and Mdm4, in human cancers. Dr. Xiong has discovered Mdm2 and Mdm4 cooperatively inhibit p53 activity during the development of the central nervous system, and Mdm2 and Mdm4 suppress p53 activity in embryonic development and adult stage, respectively. Furthermore, he shows overexpression of Mdm4 induces tumorigenesis and has a p53-independent function in mice. Dr. Xiong also demonstrates that Mdm4 overexpression cooperates with an oncogenic K-ras mutation to drive lung tumorigenesis in vivo. Dr. Xiong is also working on mutant p53 gain of function (GOF) in tumorigenesis and cancer metastasis. His work indicates phospholipase Pla2g16 mediates mutant p53 GOF in osteosarcoma metastasis. His research goal is to understand p53 pathways in vivo and identify therapeutic targets in cancer treatment.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Genetics, Division of Basic Science Research, The University of Texas, M.D.Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1995 | Shanghai Institute of Biochemistry, Chinese Academy Of Sciences, Shanghai, CHN, PHD, Biochemistry |
| 1990 | Fudan University, Shanghai, CHN, BS, Biochemistry |
Selected Publications
Peer-Reviewed Articles
- Pant V, Xiong S, Wasylishen AR, Larsson CA, Aryal NK, Chau G, Tailor RC, Lozano G. Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity. Proc Natl Acad Sci U S A 116(35):17429-17437, 2019. e-Pub 2019. PMID: 31409715.
- Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nat Commun 9(1):3953, 2018. e-Pub 2018. PMID: 30262850.
- Ortiz GJ, Li Y, Post SM, Pant V, Xiong S, Larsson CA, El-Naggar AK, Johnson DG, Lozano G. Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes. Oncogene 37(3):332-340, 2018. e-Pub 2017. PMID: 28925402.
- Pourebrahim R, Zhang Y, Liu B, Gao R, Xiong S, Lin PP, McArthur MJ, Ostrowski MC, Lozano G. Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein. Genes Dev 31(18):1847-1857, 2017. e-Pub 2017. PMID: 29021240.
- Pant V, Larsson CA, Aryal N, Xiong S, You MJ, Quintas-Cardama A, Lozano G. Tumorigenesis promotes Mdm4-S overexpression. Oncotarget 8(16):25837-25847, 2017. PMID: 28460439.
- Xiong S, Pant V, Zhang Y, Aryal NK, You MJ, Kusewitt D, Lozano G. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. J Pathol 241(4):501-510, 2017. e-Pub 2017. PMID: 27925213.
- Zhang Y, Xiong S, Li Q, Hu S, Tashakori M, Van Pelt C, You MJ, Pageon L, Lozano G. Tissue-specific and age-dependent effects of global Mdm2 loss. J Pathol 233(4):380-91, 2014. e-Pub 2014. PMID: 24789767.
- Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A 111(30):11145-50, 2014. e-Pub 2014. PMID: 25024203.
- Pant V, Xiong S, Jackson JG, Post SM, Abbas HA, Quintás-Cardama A, Hamir AN, Lozano G. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev 27(17):1857-67, 2013. e-Pub 2013. PMID: 23973961.
- Xiong S, Pant V, Suh YA, Van Pelt CS, Wang Y, Valentin-Vega YA, Post SM, Lozano G. Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4. Cancer Res 70(18):7148-54, 2010. e-Pub 2010. PMID: 20736370.
- Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G. Loss of Mdm4 Results in p53-Dependent Dilated Cardiomyopathy. Circulation 115(23):2925-2930, 2007. e-Pub 2007. PMID: 17533180.
- Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A 103(9):3226-31, 2006. e-Pub 2006. PMID: 16492743.
- Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 26(1):192-198, 2006. PMID: 16354690.
- Xiong S, Grijalva R, Zhang L, Nguyen NT, Pisters PW, Pollock RE, Yu D. Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration. Cancer Res 61(4):1727-32, 2001. PMID: 11245489.
- Xiong S, Chirala SS, Wakil SJ. Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y and Sp-1 binding sites. Proc Natl Acad Sci U S A 97(8):3948-3953, 2000. PMID: 10759542.