Simona F Shaitelman, M.D., Ed.M.
Department of Breast Radiation Oncology, Division of Radiation Oncology
About Dr. Shaitelman
Dr. Shaitelman is a Professor in the Department of Radiation Oncology at the University of Texas MD Anderson Cancer Center. She is a board-certified radiation oncologist with expertise in breast cancer treatments. Dr. Shaitelman treats all types of breast cancer and is interested in targeted radiation treatments, the interaction of radiation, breast cancer and the immune system, and lymphedema. Dr. Shaitelman is the Medical Director of the Breast Cancer-Related Lymphedema Screening Initiative, as a part of which, prospective lymphedema surveillance has become a part of the standard evaluation of breast cancer patients at MD Anderson. As a direct result, over 4,000 breast cancer patients at MD Anderson have had volumetric arm measurements and symptom-based lymphedema screening. She is a co-Investigator on an actively accruing NIH funded clinical trial, Post-Radiation Lymphatic and Systemic Immunity Changes in Post-Radiation Lymphedema development, examining the immune etiology of breast cancer-related lymphedema following radiation treatment. Dr. Shaitelman is the Principal Investigator of the Preoperative Radiotherapy to Elicit Critical Immune Stimulating Effects (PRECISE) trial, in which targeted radiation is delivered to breast cancers prior to surgery. The primary goal of this research is to understand the biological impacts of radiation in this setting and to determine if radiation may elicit an immunogenic response in these breast cancers.
Education & Training
Degree-Granting Education
| 2006 | Harvard Medical School, Boston, MA, USA, MD, Medicine |
| 2005 | Harvard Graduate School of Education, Cambridge, MA, USA, EdM, Medical Education and Adult Learning |
| 2000 | Consejo Superior de Investigaciones Cientificas, Barcelona, ESP, Fulbright Scholar, History of Medicine |
| 1999 | Princeton University, Princeton, NJ, USA, AB, History |
Postgraduate Training
| 2009-2011 | Clinical Residency, Radiation Oncology, William Beaumont Hospital, Royal Oak, MI |
| 2007-2008 | Clinical Residency, Radiation Oncology, Columbia-New York Presbyterian Hospital, New York, NY |
| 2006-2007 | Clinical Internship, Internal Medicine, The Mount Sinai Hospital, New York, NY |
Board Certifications
| 2012 | American Board of Radiology |
Experience & Service
Academic Appointments
Associate Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2023
Other Appointments/Responsibilities
Medical Director, Breast Cancer-Related Lymphedema Initiative, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2019
Associate Medical Director, Nellie B. Connally Breast Center, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2019
Institutional Committee Activities
Member, Cancer Survivorship Research Advisory Working Group, 2015 - 2020
Honors & Awards
| 2022 | Mentor to Anusha Gandhi - Early Career Oncologist Award, 104th Annual ARS Meeting |
| 2018 | Recipient, National Institutes of Health Loan Repayment Program, National Cancer Institute |
| 2017 | MD Anderson Hearst Clinical Innovator Award, The University of Texas MD Anderson Cancer Center |
| 2017 | Shirley Stein Scientific Endowed Research Award |
| 2017 | Top 1% Nationally, Consumer Assessment of Healthcare Providers and Systems Measures |
| 2014 | Recipient, National Institutes of Health Loan Repayment Program, National Cancer Institute |
| 2010 | Resident Scholarship, San Antonio Breast Cancer Symposium, American Association for Cancer Research |
| 2010 | Merit Award, ASCO Genitourinary Symposium, American Society of Clinical Oncology |
| 2010 | Resident Travel Grant Award, American Brachytherapy Society |
| 2002 | Latin American Studies Travel Grant, David Rockefeller Center, Harvard University |
| 2002 | Paul Dudley White Traveling Fellowship, Harvard Medical School |
| 1999 | Fulbright Scholar, U.S. Department of State |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Baroudi H, Huy Minh Nguyen CI, Maroongroge S, Smith BD, Niedzielski JS, Shaitelman SF, Melancon A, Shete S, Whitaker TJ, Mitchell MP, Yvonne Arzu I, Duryea J, Hernandez S, El Basha D, Mumme R, Netherton T, Hoffman K, Court L. Automated contouring and statistical process control for plan quality in a breast clinical trial. Phys Imaging Radiat Oncol 28:100486, 2023. e-Pub 2023. PMID: 37712064.
- Guhan M, Crane SM, Valerius LS, Cruz D, Smith BD, Woodward WA, Mitchell MP, Valero V, Rauch GM, Krishnamurthy S, Warnecke CL, Kuerer HM, Shaitelman SF. Patient interest in exploring non-surgical treatment approaches for early stage breast cancer: A qualitative study. Int J Radiat Oncol Biol Phys. e-Pub 2023. PMID: 37802228.
- Yoder AK, Xu T, Youssef P, DeSnyder SM, Marqueen K, Isales L, Lin R, Smith BD, Woodward WA, Stauder MC, Strom EA, Aldrich MB, Shaitelman SF. Association between symptom burden and early lymphatic abnormalities after regional nodal irradiation for breast cancer. Pract Radiat Oncol. e-Pub 2023. PMID: 37914083.
- Johnson HM, Lin H, Shen Y, Diego EJ, Krishnamurthy S, Yang WT, Smith BD, Valero V, Lucci A, Sun SX, Shaitelman SF, Mitchell MP, Boughey JC, White RL, Rauch GM, Kuerer HM, Exceptional Responders Study Group. Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy: A Nonrandomized Clinical Trial. JAMA Netw Open 6(9):e2333933, 2023. e-Pub 2023. PMID: 37707811.
- Shi JJ, Lei X, Chen YS, Chavez-MacGregor M, Bloom E, Schlembach P, Shaitelman SF, Buchholz TA, Kaiser K, Ku K, Smith BD, Smith GL. Socioeconomic Barriers to Randomized Clinical Trial Retention in Patients Treated With Adjuvant Radiation for Early-Stage Breast Cancer. Int J Radiat Oncol Biol Phys 116(1):122-131, 2023. e-Pub 2023. PMID: 36724858.
- Gandhi A, Xu T, DeSnyder SM, Smith GL, Lin R, Barcenas CH, Stauder MC, Hoffman KE, Strom EA, Ferguson S, Smith BD, Woodward WA, Perkins GH, Mitchell MP, Garner D, Goodman CR, Aldrich M, Travis M, Lilly S, Bedrosian I, Shaitelman SF. Prospective, early longitudinal assessment of lymphedema-related quality of life among patients with locally advanced breast cancer: The foundation for building a patient-centered screening program. Breast 68:205-215, 2023. e-Pub 2023. PMID: 36863241.
- De-Colle C, Kirby A, Russell N, Shaitelman SF, Currey A, Donovan E, Hahn E, Han K, Anandadas CN, Mahmood F, Lorenzen EL, van den Bongard D, Groot Koerkamp ML, Houweling AC, Nachbar M, Thorwarth D, Zips D. Adaptive radiotherapy for breast cancer. Clin Transl Radiat Oncol 39:100564, 2023. e-Pub 2022. PMID: 36632056.
- Shen Y, Ning J, Lin HY, Shaitelman SF, Kuerer HM, Bedrosian I. Effectiveness Without Efficacy: Cautionary Tale from a Landmark Breast Cancer Randomized Controlled Trial. J Cancer 14(2):193-199, 2023. e-Pub 2023. PMID: 36741254.
- Vang AR, Shaitelman SF, Rasmussen JC, Chan W, Sevick-Muraca EM, Aldrich MB. Plasma Cytokines/Chemokines as Predictive Biomarkers for Lymphedema in Breast Cancer Patients. Cancers (Basel) 15(3), 2023. e-Pub 2023. PMID: 36765631.
- Corrigan KL, Kouzy R, Jaoude JA, Patel RR, Layman RM, Giordano SH, Woodward WA, Smith BD, Shaitelman SF, Ludmir EB. Inclusion of premenopausal women in breast cancer clinical trials. Breast 66:204-207, 2022. e-Pub 2022. PMID: 36327626.
- Farley CR, Irwin S, Adesoye T, Sun SX, DeSnyder SM, Lucci A, Shaitelman SF, Chang EI, Ueno NT, Woodward WA, Teshome M. Lymphedema in Inflammatory Breast Cancer Patients Following Trimodal Treatment. Ann Surg Oncol 29(10):6370-6378, 2022. e-Pub 2022. PMID: 35854031.
- Bright SJ, Flint DB, Martinus DKJ, Turner BX, Manandhar M, Kacem MB, McFadden CH, Yap TA, Shaitelman SF, Sawakuchi GO. Targeted Inhibition of DNA-PKcs, ATM, ATR, PARP, and Rad51 Modulate Response to X Rays and Protons. Radiat Res 198(4):336-346, 2022. e-Pub 2022. PMID: 35939823.
- Farley CR, Irwin S, Adesoye T, Sun SX, DeSnyder SM, Lucci A, Shaitelman SF, Chang EI, Ueno NT, Woodward WA, Teshome M. ASO Visual Abstract: Lymphedema in Inflammatory Breast Cancer Patients Following Trimodal Treatment. Ann Surg Oncol 29(10):6379-6380, 2022. e-Pub 2022. PMID: 36030283.
- Aldrich MB, Rasmussen JC, DeSnyder SM, Woodward WA, Chan W, Sevick-Muraca EM, Mittendorf EA, Smith BD, Stauder MC, Strom EA, Perkins GH, Hoffman KE, Mitchell MP, Barcenas CH, Isales LE, Shaitelman SF. Prediction of breast cancer-related lymphedema by dermal backflow detected with near-infrared fluorescence lymphatic imaging. Breast Cancer Res Treat 195(1):33-41, 2022. e-Pub 2022. PMID: 35816269.
- Flint DB, Ruff CE, Bright SJ, Yepes P, Wang Q, Manandhar M, Kacem MB, Turner BX, Martinus DKJ, Shaitelman SF, Sawakuchi GO. An empirical model of proton RBE based on the linear correlation between x-ray and proton radiosensitivity. Med Phys. e-Pub 2022. PMID: 35831779.
- Andring LM, Diao K, Sun S, Patel M, Whitman GJ, Schlembach P, Arzu I, Joyner MM, Shaitelman SF, Hoffman K, Stauder MC, Smith BD, Woodward WA. Locoregional Management and Prognostic Factors in Breast Cancer With Ipsilateral Internal Mammary and Axillary Lymph Node Involvement. Int J Radiat Oncol Biol Phys 113(3):552-560, 2022. e-Pub 2022. PMID: 35248602.
- Manandhar M, Bright SJ, Flint DB, Martinus DKJ, Kolachina RV, Kacem MB, Titt U, Martin TJ, Lee CL, Morrison K, Shaitelman SF, Sawakuchi G. Effect of boron compounds on the biological effectiveness of proton therapy. Med Phys. e-Pub 2022. PMID: 35754208.
- Hanson SE, Lei X, Roubaud MS, DeSnyder SM, Caudle AS, Shaitelman SF, Hoffman KE, Smith GL, Jagsi R, Peterson SK, Smith BD. Long-term Quality of Life in Patients With Breast Cancer After Breast Conservation vs Mastectomy and Reconstruction. JAMA Surg 157(6):e220631, 2022. e-Pub 2022. PMID: 35416926.
- Corrigan KL, Lei X, Ahmad N, Arzu I, Bloom E, Chun SG, Goodman C, Hoffman KE, Joyner M, Mayo L, Mitchell M, Nead KT, Perkins GH, Reed V, Reddy JP, Schlembach P, Shaitelman SF, Stauder MC, Strom EA, Tereffe W, Wiederhold L, Woodward WA, Smith BD. Adoption of Ultrahypofractionated Radiation Therapy in Patients With Breast Cancer. Adv Radiat Oncol 7(2):100877, 2022. e-Pub 2021. PMID: 35387420.
- Chapman BV, Liu D, Shen Y, Olamigoke OO, Lakomy DS, Barrera AMG, Stecklein SR, Sawakuchi GO, Bright SJ, Bedrosian I, Litton JK, Smith BD, Woodward WA, Perkins GH, Hoffman KE, Stauder MC, Strom EA, Arun BK, Shaitelman SF. Outcomes after breast radiotherapy in a diverse patient cohort with a germline BRCA1/2 mutation. Int J Radiat Oncol Biol Phys 112(2):426-436, 2022. e-Pub 2021. PMID: 34610390.
- Chapman BV, Liu D, Shen Y, Olamigoke OO, Lakomy DS, Barrera AMG, Stecklein SR, Sawakuchi GO, Bright SJ, Bedrosian I, Litton JK, Smith BD, Woodward WA, Perkins GH, Hoffman KE, Stauder MC, Strom EA, Arun BK, Shaitelman SF. Breast Radiation Therapy-Related Treatment Outcomes in Patients With or Without Germline Mutations on Multigene Panel Testing. Int J Radiat Oncol Biol Phys 112(2):437-444, 2022. e-Pub 2021. PMID: 34582940.
- Nowakowska MK, Lei X, Thompson MT, Shaitelman SF, Wehner MR, Woodward WA, Giordano SH, Nead KT. Association of statin use with clinical outcomes in patients with triple-negative breast cancer. Cancer 127(22):4142-4150, 2021. e-Pub 2021. PMID: 34342892.
- Swanick CW, Jiang J, Maldonado JA, Lei X, Shih YT, Caudle AS, Baumann DP, Giordano SH, Shaitelman SF, Shirvani SM, Smith BD. Differences in Time Burden across Local Therapy Strategies for Early-stage Breast Cancer. Plast Reconstr Surg Glob Open 9(11):e3904, 2021. e-Pub 2021. PMID: 34745797.
- Weng JK, Lei X, Schlembach P, Bloom ES, Shaitelman SF, Arzu IY, Chronowski G, Dvorak T, Grade E, Hoffman K, Perkins G, Reed VK, Shah SJ, Stauder MC, Strom EA, Tereffe W, Woodward WA, Hortobagyi GN, Hunt KK, Buchholz TA, Smith BD. Five-Year Longitudinal Analysis of Patient-Reported Outcomes and Cosmesis in a Randomized Trial of Conventionally Fractionated Versus Hypofractionated Whole-Breast Irradiation. Int J Radiat Oncol Biol Phys 111(2):360-370, 2021. e-Pub 2021. PMID: 33992718.
- Shah C, Jia X, Hobbs BP, Tendulkar RD, Sittenfeld SMC, Al-Hilli Z, Arthur DW, Keisch ME, Khan AJ, Shaitelman SF, Boyages J, Wazer D, Kundu N, Vicini FA. Outcomes with Partial Breast Irradiation vs. Whole Breast Irradiation: a Meta-Analysis. Ann Surg Oncol 28(9):4985-4994, 2021. e-Pub 2021. PMID: 33393051.
- Tamirisa N, Lin H, Shen Y, Shaitelman SF, Karuturi MS, Giordano SH, Babiera GV, Bedrosian I. Impact of adjuvant endocrine therapy in older patients with comorbidities and estrogen receptor-positive, node-negative breast cancer-A National Cancer Database analysis. Cancer 127(13):2196-2203, 2021. e-Pub 2021. PMID: 33735487.
- Boyce-Fappiano D, Bedrosian I, Shen Y, Lin H, Gjyshi O, Yoder A, Shaitelman SF, Woodward WA. Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis. NPJ Breast Cancer 7(1):87, 2021. e-Pub 2021. PMID: 34226566.
- Flint DB, Bright SJ, McFadden CH, Konishi T, Ohsawa D, Turner B, Lin SH, Grosshans DR, Chiu HS, Sumazin P, Shaitelman SF, Sawakuchi GO. Cell lines of the same anatomic site and histologic type show large variability in intrinsic radiosensitivity and relative biological effectiveness to protons and carbon ions. Med Phys 48(6):3243-3261, 2021. e-Pub 2021. PMID: 33837540.
- Gao R, Bai S, Henderson YC, Lin Y, Schalck A, Yan Y, Kumar T, Hu M, Sei E, Davis A, Wang F, Shaitelman SF, Wang JR, Chen K, Moulder S, Lai SY, Navin NE. Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes. Nat Biotechnol 39(5):599-608, 2021. e-Pub 2021. PMID: 33462507.
- Lim B, Song J, Ibrahim NK, Koenig KB, Chavez-MacGregor M, Ensor JE, Gomez JS, Krishnamurthy S, Caudle AS, Shaitelman SF, Whitman GJ, Valero V. A Randomized Phase II Study of Sequential Eribulin Versus Paclitaxel Followed by FAC/FEC as Neoadjuvant Therapy in Patients with Operable HER2-Negative Breast Cancer. Oncologist 26(2):e230-e240, 2021. e-Pub 2020. PMID: 33140515.
- Pasalic D, Strom EA, Allen PK, Williamson TD, Poenisch F, Amos RA, Woodward WA, Stauder MC, Shaitelman SF, Smith BD, Perkins GH, Tereffe W, Hoffman KE. Proton Accelerated Partial Breast Irradiation: Clinical Outcomes at a Planned Interim Analysis of a Prospective Phase 2 Trial. Int J Radiat Oncol Biol Phys 109(2):441-448, 2021. e-Pub 2020. PMID: 32946965.
- Thaker NG, Boyce-Fappiano D, Ning MS, Pasalic D, Guzman A, Smith G, Holliday EB, Incalcaterra J, Garden AS, Shaitelman SF, Gunn GB, Fuller CD, Blanchard P, Feeley TW, Kaplan RS, Frank SJ. Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer. Int J Part Ther 8(1):374-382, 2021. e-Pub 2021. PMID: 34285963.
- Brunelle CL, Barrio AV, Shaitelman SF, Singhal D, Sayegh HE, Taghian AG. On "Diagnosis of Upper Quadrant Lymphedema Secondary to Cancer: Clinical Practice Guideline from the Oncology Section of the American Physical Therapy Association." Levenhagen K, Davies C, Perdomo M, Ryans K, Gilchrist L. Phys Ther. 2017;97:729-745. Phys Ther 98(4):277-281, 2018. PMID: 29617972.
- Swanick CW, Lei X, Xu Y, Shen Y, Goodwin NA, Smith GL, Giordano SH, Hunt KK, Jagsi R, Shaitelman SF, Peterson SK, Smith BD. Long-term Patient-Reported Outcomes in Older Breast Cancer Survivors: A Population-Based Survey Study. Int J Radiat Oncol Biol Phys 100(4):882-890, 2018. e-Pub 2017. PMID: 29485067.
- Ayoub Z, Strom EA, Ovalle V, Perkins GH, Woodward WA, Tereffe W, Smith BD, Shaitelman SF, Stauder MC, Hoffman KE, DeSnyder SM, Garvey PB, Clemens MW, Barcenas CH, Kuerer HM, Kronowitz S. A 10-Year Experience with Mastectomy and Tissue Expander Placement to Facilitate Subsequent Radiation and Reconstruction. Ann Surg Oncol. e-Pub 2017. PMID: 28766219.
- Shaitelman SF, Chiang YJ, Griffin KD, De Snyder SM, Smith BD, Schaverien MV, Woodward WA, Cormier JN. Erratum to: Radiation therapy targets and the risk of breast cancer-related lymphedema: a systematic review and network meta-analysis. Breast Cancer Res Treat 162(2):217, 2017. PMID: 28185145.
- Loveland-Jones C, Lin H, Shen Y, Bedrosian I, Shaitelman S, Kuerer H, Woodward W, Ueno N, Valero V, Babiera G. Disparities in the use of postmastectomy radiation therapy for inflammatory breast cancer. Int J Radiat Oncol Biol Phys 95(4):1218-25, 2016. e-Pub 2016. PMID: 27209502.
- Shirvani SM, Jiang J, Likhacheva A, Hoffman KE, Shaitelman SF, Caudle A, Buchholz TA, Giordano SH, Smith BD. Trends in local therapy utilization and cost for early-stage breast cancer in older women: Implications for payment and policy reform. Int J Radiat Oncol Biol Phys 95(2):605-16, 2016. e-Pub 2016. PMID: 27034179.
- Ovalle V, Strom EA, Godby J, Shaitelman SF, Stauder MC, Amos RA, Kuerer HM, Woodward WA, Hoffman KE. Proton partial-breast irradiation for early-stage cancer: Is it really so costly?. Int J Radiat Oncol Biol Phys 95(1):49-51, 2016. PMID: 27084625.
- Pan HY, Shaitelman SF, Perkins GH, Schlembach PJ, Woodward WA, Smith BD. Implementing a real-time electronic data capture system to improve clinical documentation in radiation oncology. J Am Coll Radiol 13(4):S1546, 2016. e-Pub 2015. PMID: 26681164.
- Caudle AS, Yang WT, Krishnamurthy S, Mittendorf EA, Black DM, Gilcrease MZ, Bedrosian I, Hobbs BP, DeSnyder SM, Hwang RF, Adrada BE, Shaitelman SF, Chavez-MacGregor M, Smith BD, Candelaria RP, Babiera GV, Dogan BE, Santiago L, Hunt KK, Kuerer HM. Improved Axillary Evaluation Following Neoadjuvant Therapy for Patients With Node-Positive Breast Cancer Using Selective Evaluation of Clipped Nodes: Implementation of Targeted Axillary Dissection. J Clin Oncol 34(10):1072-8, 2016. e-Pub 2016. PMID: 26811528.
- Swisher SK, Vila J, Tucker SL, Bedrosian I, Shaitelman SF, Litton JK, Smith BD, Caudle AS, Kuerer HM, Mittendorf EA. Locoregional Control According to Breast Cancer Subtype and Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Undergoing Breast-conserving Therapy. Ann Surg Oncol 23(3):749-56, 2016. e-Pub 2015. PMID: 26511263.
- Huo J, Giordano SH, Smith BD, Shaitelman SF, Smith GL. Contemporary Toxicity Profile of Breast Brachytherapy Versus External Beam Radiation After Lumpectomy for Breast Cancer. Int J Radiat Oncol Biol Phys 94(4):709-718, 2016. e-Pub 2015. PMID: 26972643.
- Shaitelman SF, Lin HY, Smith BD, Shen Y, Bedrosian I, Marsh GD, Bloom ES, Vicini FA, Buchholz TA, Babiera GV. Practical implications of hte publication of consensus guidelines by the American Society for Radiation Oncology: accelerated partial breast irradiation and the National Cancer Data Base. Int J Radiat Oncol Biol Phys 94(1):338-348, 2016. e-Pub 2015. PMID: 26853342.
- Bishop AJ, Ensor J, Moulder SL, Shaitelman SF, Edson MA, Whitman GJ, Bishnoi S, Hoffman KE, Stauder MC, Valero V, Buchholz TA, Ueno NT, Babiera G, Woodward WA. Prognosis for patients with metastatic breast cancer who achieve a no-evidence-of-disease status after systemic or local therapy. Cancer 121(24):4324-32, 2015. e-Pub 2015. PMID: 26348887.
- Voss RK, Cromwell KD, Chiang YJ, Armer JM, Ross MI, Lee JE, Gershenwald JE, Stewart BR, Shaitelman SF, Cormier JN. The long-term risk of upper-extremity lymphedema is two-fold higher per lymph node removed in breast cancer patients than in melanoma patients. J Surg Oncol 112(8):834-40, 2015. e-Pub 2015. PMID: 26477877.
- Grant SR, Walker GV, Koshy M, Shaitelman SF, Klopp AH, Frank SJ, Pugh TJ, Allen PK, Mahmood U. Impact of insurance status on radiation treatment modality selection among potential candidates for prostate, breast or gynecologic brachytherapy. Int J Radiat Oncol Biol Phys 93(5):968-75, 2015. e-Pub 2015. PMID: 26452570.
- Shah C, Vicini FA, Berry S, Julian TB, Wilkinson JB, Shaitelman SF, Khan A, Finkelstein SE, Goldstein N. Ductal carcinoma in situ of the breast: evaluating the role of radiation therapy in the management and attempts to identify low-risk patients. Am J Clin Oncol 38(5):526-33, 2015. e-Pub 2014. PMID: 25036472.
- Shaitelman SF, Schlembach PJ, Arzu I, Ballo M, Bloom ES, Buchholz D, Chronowski GM, Dvorak T, Grade E, Hoffman KE, Kelly P, Ludwig M, Perkins GH, Reed V, Shah S, Stauder MC, Strom EA, Tereffe W, Woodward WA, Ensor J, Baumann D, Thompson AM, Amaya D, Davis T, Guerra W, Hamblin L, Hortobagyi G, Hunt KK, Buchholz TA, Smith BD. Acute and Short-term Toxic Effects of Conventionally Fractionated vs Hypofractionated Whole-Breast Irradiation: A Randomized Clinical Trial. JAMA Oncol 1(7):931-41, 2015. e-Pub 2015. PMID: 26247543.
- Shaitelman SF, Tereffe W, Dogan BE, Hess KR, Caudle AS, Valero V, Stauder MC, Krishnamurthy S, Candelaria RP, Strom EA, Woodward WA, Hunt KK, Buchholz TA, Whitman GJ. Role of Ultrasonography of Regional Nodal Basins in Staging Triple-Negative Breast Cancer and Implications For Local-Regional Treatment. Int J Radiat Oncol Biol Phys 93(1):102-10, 2015. e-Pub 2015. PMID: 26279028.
- Lautner M, Lin H, Shen Y, Parker C, Kuerer H, Shaitelman S, Babiera G, Bedrosian I. Disparities in the use of breast-conserving therapy among patients with early-stage breast cancer. JAMA Surg 150(8):778-86, 2015. e-Pub 2015. PMID: 26083835.
- Strom EA, Amos RA, Shaitelman SF, Kerr MD, Hoffman KE, Smith BD, Tereffe W, Stauder MC, Perkins GH, Amin MD, Wang X, Poenisch F, Ovalle V, Buchholz TA, Babiera G, Woodward WA. Proton partial breast irradiation in the supine position: Treatment description and reproducibility of a multibeam technique. Pract Radiat Oncol 5(4):e283-90. e-Pub 2015. PMID: 25804105.
- Wobb JL, Chen PY, Shah C, Moran MS, Shaitelman SF, Vicini FA, Mbah AK, Lyden M, Beitsch P. Nomogram for predicting the risk of locoregional recurrence in patients treated with accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys 91(2):312-318, 2015. e-Pub 2014. PMID: 25446607.
- Thaker NG, Hoffman KE, Stauder MC, Shaitelman SF, Strom EA, Tereffe W, Smith BD, Perkins GH, Huo L, Munsell MF, Pusztai L, Buchholz TA, Woodward WA. The 21-gene recurrence score complements IBTR! Estimates in early-stage, hormone receptor-positive, HER2-normal, lymph node-negative breast cancer. Springerplus 4:36, 2015. e-Pub 2015. PMID: 25674496.
- Shaitelman S, Buchholz TA, Hunt KK, Hortobagyi G, Schlembach P, Arzu I, Bloom E, Chronowski G, Dvorak T, Grade Hoffman K, Perkins G, Reed V, Shah S, Stauder M, Strom E, Tereffe W, Woodward W, Smith BD. Hypofractionated whole breast irradiation results in less acute toxicity and improved quality of life at 6 months compared to conventionally fractionated whole breast irradiation: results of a randomized trial. Proceedings of the American Society for Radiation Oncology 56th Annual Meeting 90(5):1264, 2014. PMID: 95539386.
- Mittendorf EA, Caudle AS, Yang W, Krishnamurthy S, Shaitelman S, Chavez-MacGregor M, Woodward WA, Bedrosian I, Kuerer HM, Hunt KK. Implementation of the American College of Surgeons Oncology Group Z1071 trial data in clinical practice: is there a way forward for sentinel lymph node dissection in clinically node-positive breast cancer patients treated with neoadjuvant chemotherapy?. Ann Surg Oncol 21(8):2468-73, 2014. e-Pub 2014. PMID: 24841348.
- Haynes AB, Bloom ES, Bedrosian I, Kuerer HM, Hwang RF, Munsell MF, Chemaly RF, Graviss LS, Caudle AS, Hunt KK, Tereffe W, Shaitelman SF, Babiera GV. Timing of Infectious Complications Following Breast-Conserving Therapy with Catheter-Based Accelerated Partial Breast Irradiation. Ann Surg Oncol 21(8):2512-2516, 2014. e-Pub 2014. PMID: 24736987.
- Rueth NM, Lin HY, Bedrosian I, Shaitelman SF, Ueno NT, Shen Y, Babiera G. Underuse of Trimodality Treatment Affects Survival for Patients With Inflammatory Breast Cancer: An Analysis of Treatment and Survival Trends From the National Cancer Database. J Clin Oncol 32(19):2018-2024, 2014. e-Pub 2014. PMID: 24888808.
- MacDermed DM, Houtman KM, Thang SH, Allen PK, Caudle AS, Gainer SM, Hunt KK, Perkins GH, Shaitelman SF, Smith BD, Strom EA, Tereffe W, Woodward WA, Buchholz TA, Hoffman KE. Therapeutic radiation dose delivered to the low axilla during whole breast radiotherapy in the prone position: implications for targeting the undissected axilla. Pract Radiat Oncol 4(2):116-122, 2014. e-Pub 2013. PMID: 24890352.
- Shaitelman SF, Khan AJ, Woodward WA, Arthur DW, Cuttino LW, Bloom ES, Shah C, Freedman GM, Wilkinson JB, Babiera GV, Julian TB, Vicini FA. Shortened radiation therapy schedules for early stage breast cancer: A review of hypofractionated whole breast irradiation and accelerated partial breast irradiation. Breast J 20(2):131-46, 2014. e-Pub 2014. PMID: 24479632.
- Wang X, Zhang X, Li X, Amos RA, Shaitelman SF, Hoffman K, Howell R, Salehpour M, Zhang SX, Sun TL, Smith B, Tereffe W, Perkins GH, Buchholz TA, Strom EA, Woodward WA. Accelerated partial-breast irradiation using intensity-modulated proton radiotherapy: do uncertainties outweigh potential benefits?. Br J Radiol 86(1029):20130176, 2013. e-Pub 2013. PMID: 23728947.
- Wilkinson JB, Beitsch PD, Shah C, Arthur D, Haffty BG, Wazer DE, Keisch M, Shaitelman SF, Lyden M, Chen PY, Vicini FA. Evaluation of Current Consensus Statement Recommendations for Accelerated Partial Breast Irradiation: A Pooled Analysis of William Beaumont Hospital and American Society of Breast Surgeon MammoSite(®) Registry Trial Data. Int J Radiat Oncol Biol Phys 85(5):1179-85, 2013. e-Pub 2012. PMID: 23182700.
- Wilkinson JB, Vicini FA, Shah C, Shaitelman S, Jawad MS, Ye H, Kestin LL, Goldstein NS, Martinez AA, Benitez P, Chen PY. Twenty-Year Outcomes after Breast-Conserving Surgery and Definitive Radiotherapy for Mammographically Detected Ductal Carcinoma In Situ. Ann Surg Oncol 19(12):3785-91, 2012. e-Pub 2012. PMID: 22644510.
- Shaitelman SF, Wilkinson JB, Kestin LL, Ye H, Goldstein NS, Martinez AA, Vicini FA. Long-Term Outcome in Patients with Ductal Carcinoma in situ Treated with Breast-Conserving Therapy: Implications for Optimal Follow-up Strategies. Int J Radiat Oncol Biol Phys 83(3):e305-12, 2012. e-Pub 2012. PMID: 22417804.
- Shaitelman SF, Vicini FA, Grills IS, Martinez AA, Yan D, Kim LH. Differences in Effective Target Volume Between Various Techniques of Accelerated Partial Breast Irradiation. Int J Radiat Oncol Biol Phys 82(1):30-6, 2012. e-Pub 2010. PMID: 21050674.
- Shaitelman SF, Grills IS, Kestin LL, Ye H, Nandalur S, Huang J, Vicini FA. Rates of Second Malignancies After Definitive Local Treatment for Ductal Carcinoma In Situ of the Breast. Int J Radiat Oncol Biol Phys 81(5):1244-51, 2011. e-Pub 2010. PMID: 21030159.
- Wilkinson JB, Reid RE, Shaitelman SF, Chen PY, Mitchell CK, Wallace MF, Marvin KS, Grills IS, Margolis JM, Vicini FA. Outcomes of Breast Cancer Patients With Triple Negative Receptor Status Treated With Accelerated Partial Breast Irradiation. Int J Radiat Oncol Biol Phys 81(3):S227-S228, 2011. e-Pub 2011. PMID: 21345613.
- Shaitelman SF, Kim LH, Grills IS, Chen PY, Ye H, Kestin LL, Yan D, Vicini FA. Predictors of Long-Term Toxicity Using Three-Dimensional Conformal External Beam Radiotherapy To Deliver Accelerated Partial Breast Irradiation. Int J Radiat Oncol Biol Phys 81(3):788, 2011. e-Pub 2010. PMID: 20933342.
- Shah C, Wilkinson JB, Shaitelman S, Grills I, Wallace M, Mitchell C, Vicini F. Clinical outcomes using accelerated partial breast irradiation in patients with invasive lobular carcinoma. Int J Radiat Oncol Biol Phys 81(4):e547-541, 2011. e-Pub 2011. PMID: 21640491.
- Shaitelman SF, Kim LH, Yan D, Martinez AA, Vicini FA, Grills IS. Continuous arc rotation of the couch therapy for the delivery of accelerated partial breast irradiation: a treatment planning analysis. Int J Radiat Oncol Biol Phys 80(3):771-8, 2011. e-Pub 2010. PMID: 20584586.
Invited Articles
- Shaitelman SF, Cromwell KD, Rasmussen JC, Stout NL, Armer JM, Lasinski BB, Cormier JN. Recent progress in the treatment and prevention of cancer-related lymphedema. CA Cancer J Clin 65(1):55-81, 2015. e-Pub 2014. PMID: 25410402.
- Beitsch PD, Shaitelman SF, Vicini FA. Accelerated partial breast irradiation. J Surg Oncol 103(4):362-8, 2011. PMID: 21337572.
- Théberge V, Whelan T, Shaitelman SF, Vicini FA. Altered fractionation: rationale and justification for whole and partial breast hypofractionated radiotherapy. Semin Radiat Oncol 21(1):55-65, 2011. PMID: 21134655.
Editorials
- Shaitelman SF. Sounding a warning bell? Documentation of the increased utilization of accelerated partial breast irradiation. J Natl Cancer Inst 104(1):5-7, 2012. PMID: 22180644.
Abstracts
- Mamounas EP, Bandos H, White JR, Julian TB, Khan TJ, Shaitelman SF, Torres MA, Vicini F, Ganz PA, McCloskey SA, Paik S, Gupta N, Li XA, DiCostanzo DJ, Costantino JP, Curran WJ, Wolmark N. NRG Oncology/NSABP B-51/RTOG 1304: Phase III trial to determine if chest wall and regional nodal radiotherapy (CWRNRT) post mastectomy (Mx) or the addition of RNRT to breast RT post breast-conserving surgery (BCS) reduces invasive breast cancer recurrence free interval (IBCRFI) in patients (pts) with positive axillary (PAx) nodes who are ypN0 after neoadjuvant chemotherapy (NC). J Clin Oncol 34(15_suppl):TPS 1097, 2016.
- Mamounas EP, Bandos H, White JR, Julian TB, Kahn AJ, Shaitelman SF, Torres MA, McCloskey SA, Vicini FA, Ganz PA, Paik S, Gupta N, Costantino JP, Curran Jr WJ, Wolmark N. NRG Oncology/NSABP B-51/RTOG 1304: Phase III trial to determine if chest wall and regional nodal radiotherapy (CWRNRT) post mastectomy (Mx) or the addition of RNRT to breast RT post breast-conserving surgery (BCS) will reduce invasive cancer events in patients (pts) with positive axillary (Ax) nodes who are ypN0 after neoadjuvant chemotherapy (NC). J Clin Oncol 33(15_suppl):TPS11112, 2015.
- Shaitelman SF, Buchholz TA, Hunt KK, Hortobagyi GN, Schlembach P, Arzu I, Bloom E, Chronowski G, Dvorak T, Grade E, Hoffman KE, Perkins GH, Reed V, Shah S, Stauder MC, Strom EA, Tereffe W, Woodward WA, Ensor J, Smith BD. Hypofractionated whole breast irradiation results in less acute toxicity and improved quality of life at six months compared to conventionally fractionated whole breast irradiation: results of a randomized trial. Int J Radiat Oncol Biol Phys 90(5):1264, 2014.
Letters to the Editor
- Kim L, Shaitelman S. What is the target volume for preoperative accelerated partial breast irradiation (APBI)? In regards to Nichols et al. (Int J Radiat Oncol Biol Phys 2010;77:197-202) and Palta et al. (Int J Radiat Oncol Biol Phys 2010, in Press). Int J Radiat Oncol Biol Phys 80: 314-5; author reply 315-6, 2011.
Grant & Contract Support
| Title: | Lymphatic and systemic immunity changes in post-radiation lymphedema development |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Preoperative Radiotherapy to Elicit Critical Immune Stimulating Effects |
| Funding Source: | Breast Cancer Moonshot, The University of Texas MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Radiation to Stimulate Anti-Cancer Immunity in Breast Cancer |
| Funding Source: | Institutional Research Grant, The University of Texas MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | |
| Funding Source: | Start Up Funds, The University of Texas MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | A framework to use DNA Repair to IndiVidualizE Radiotherapy (DRIVER) |
| Funding Source: | Sister Institution Network Fund, The University of Texas MD Anderson Cancer Center |
| Role: | Co-Investigator |
| Title: | A consortium for automated radiotherapy treatment planning in Latin America |
| Funding Source: | Sister Institution Network Fund, The University of Texas MD Anderson Cancer Center |
| Role: | Collaborator |
| Title: | Impacting cancer outcomes through enhanced linear energy transfer proton therapy (ELPT) |
| Funding Source: | Department of Radiation Oncology Shark Tank, The University of Texas MD Anderson Cancer Center |
| Role: | Co-Investigator |
| Title: | Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy: Core 2: Translational Biospecimens and Imaging Biomarkers |
| Funding Source: | NIH/NCI |
| Role: | Core Lead |
| Title: | Omission of Surgery in Excellent Responders to MRI-Guided Stereotactic Ablative Radiotherapy to Breast Cancer |
| Funding Source: | ROSI Advanced Imaging Initiative Grant, The University of Texas MD Anderson Cancer Center |
| Role: | Principal Investigator |