Simone Anfossi, Ph.D.
Department of Translational Molecular Pathology, Division of Pathology-Lab Medicine Div
About Dr. Simone Anfossi
Dr. Anfossi’s research focuses on tumor immunology and tumor microenvironment (TME). He is particularly interested in investigating the role of molecular cargo (non-coding RNAs: ncRNAs) of extracellular vesicles (EVs) in regulating the effect of the crosstalk among cancer cells and tumor-associated cells (T cells, NK cells, dendritic cells, macrophages) on their cell biology functions.
Dr. Anfossi's journey in tumor immunology began after his BS/MS degree in molecular biology at the University of Genoa, Italy. He started as a fellow in the Immunopathology Laboratory of Dr. Lorenzo Moretta at the National Institute for Cancer Research, Genoa, Italy, where he focused on the anti-tumor functions of T lymphocytes. His interest in tumor immunology deepened during his time as a Visiting Research Fellow in the Cancer Immunotherapy Research Lab of Dr. Alessandro D. Santin at The University of Arkansas for Medical Sciences, USA, where he worked on the development of dendritic cell-based immunotherapy for ovarian cancer.
At The University of Texas MD Anderson Cancer Center, Dr. Anfossi's research took a new direction. He delved into the molecular biology of ncRNAs (microRNAs: miRNAs, long non-coding RNAs: lncRNAs) and EVs in the TME. This focus on the role of miRNAs, lncRNAs, and EVs has been a consistent thread throughout his graduate student, Postdoctoral Fellow, and Instructor time. After starting a research collaboration with Dr. Moran Amit, Dr. Anfossi included the tumor-associated nerves as additional components in regulating the TME and players in the EV-mediated crosstalk.
The main goal of Dr. Anfossi's research is to study the role of EVs in modulating the TME to promote tumor progression, tumor immune escape, and treatment resistance development. Studying the functional role of extracellular ncRNAs carried by secreted EVs will help gain further insights into understanding the molecular mechanisms in the TME regulating cancer initiation and progression and identifying new potential targets for novel cancer therapy. Dr. Anfossi is also involved in the development of engineered EVs to target cancer cells with aggressive phenotypes, such as cancer stem-like (CSC) with epithelial-to-mesenchymal transition (EMT) characteristics, in the TME of triple-negative breast cancer (TNBC).
Present Title & Affiliation
Primary Appointment
Assistant Professor, Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Dr. Simone Anfossi is a molecular biologist interested in tumor immunology, tumor microenvironment, and extracellular vesicle biology. His research aims to understand the role of extracellular vesicles in mediating intercellular communication in the tumor microenvironment, with particular focus on the crosstalk between cancer cells and tumor-associated cells (immune cells and tumor-infiltrating nerves) and the effect on tumor progression, tumor immune escape, and treatment resistance development. The long-term goal of Dr. Anfossi’s research is the development of novel therapeutic strategies to target TME cells using engineered extracellular vesicles.
Education & Training
Degree-Granting Education
| 2013 | The University of Texas Health Science Center, Houston, Texas, US, Tumor Immunology, Ph.D. in Biomedical Sciences |
| 1998 | University of Genoa, Genoa, IT, Molecular Biology, B.S. in Molecular Biology |
| 1998 | University of Genoa, Genoa, IT, Molecular Biology, M.S. in Molecular Biology |
Postgraduate Training
| 2016-2019 | Postdoctoral Fellow, Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2013-2016 | Postdoctoral Fellow, Tumor Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Faculty Academic Appointments
Instructor, Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2020 - 2023
Instructor, Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2020
Intramural Institutional Committee Activities
Member, Junior Faculty Committee - Education and Teaching Subcommittee, The University of Texas MD Anderson Cancer Center, 2026 - Present
Member, Faculty Launchpad Program, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, RFA Task Force Think Tanks, The University of Texas MD Anderson Cancer Center, 2025 - 2025
Co-Chair, 2024 Translational Molecular Pathology Department Retreat, The University of Texas MD Anderson Cancer Center, 2024 - 2024
Co-Chair, Translational Molecular Pathology Think Tank Seminar Series, The University of Texas MD Anderson Cancer Center, 2022 - 2025
Reviewer, Academic Review Committee, The University of Texas MD Anderson Cancer Center, 2020 - Present
Co-Chair, Experimental Therapeutics Postdoctoral Seminars, The University of Texas MD Anderson Cancer Center, 2017 - 2018
Editorial Activities
Co-Editor for Research Topic, Frontiers in Cell and Developmental Biology, 2026 - Present
Invite Guest Editor - Special Issue, Journal of Clinical and Translational Research, 2026 - Present
Invited Guest Editor - article collection, Scientific Reports, 2026 - Present
Editorial Board - Board Member, BMC Cancer, 2026 - Present
Editorial Board - Board Member, International Journal of Molecular Sciences - Molecular Oncology, 2025 - Present
Invited book proposal reviewer, Royal Society of Chemistry, 2025
Academic Editor - book, IntechOpen, 2024 - Present
Guest Editor - article collection, Scientific Reports, 2024 - Present
Editorial Board - Board Member, Scientific Reports, 2024 - Present
Editorial Board - Board Member, Journal of Clinical and Translational Research, 2024 - Present
Invited Guest Editor - special issue, Extracellular Vesicles and Circulating Nucleic Acids, 2023 - Present
Invited Review Editor - article collection, Frontiers in Oncology, 2022 - 2024
Invited Guest Editor - special issue, International Journal of Molecular Sciences, 2022 - Present
Invited Guest Editor - special issue, Biomolecules, 2020 - 2023
Review Editor, Cancer Molecular Targets and Therapeutics, 2019 - Present
Honors & Awards
| 2019 | The Thomas H. and Mayme P. Scott Fellowship in Cancer Research The Thomas H. and Mayme P. Scott Foundation, Inc, The Thomas H. and Mayme P. Scott Foundation, Inc |
| 2018 | AAAS/Science Program for Excellence, AAAS Science |
| 2018 | The Diane Denson Tobola Fellowship in Ovarian Cancer Research, The Diane Denson Tobola |
| 2017 | The Thomas H. and Mayme P. Scott Fellowship in Cancer Research, The Thomas H. and Mayme P. Scott Foundation, Inc |
| 2015 | Award in Translational/Clinical Research, Agilent |
| 2014 | Award in Translational Research, The Bayer HealthCare Pharmaceuticals, Inc |
| 2012 | AACR Scholar-In-Training Award, Susan G. Komen for the Cure |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2023. Inside and outside tumor cell functions of miRNAs: two faces of the same coin driving tumor progression in TNBC. Invited. Translational Breast Cancer Research Meeting. Houston, TX, US.
- 2021. High levels of miR-19a are associated with triple negative subtype and poor prognosis: potential target for anti-miRNA therapy. Invited. Morgan Welch Inflammatory Breast Cancer Research Program and Clinic. Houston, TX, US.
- 2021. High levels of miR-19a are associated with triple negative subtype and poor prognosis: potential target for anti-miRNA therapy. Conference. Division of Pathology & Laboratory Medicine 1st Annual Research Symposium. Houston, TX, US.
- 2020. ncRNAs: ‘inside out’ cancer regulomers. Invited. RNA Collaborative Seminars, US.
- 2017. Pyknon: Human Specific Short Genomic Elements with Regulatory Functions. Invited. Institutional Grand Round (New Developments in ncRNA Research). Houston, TX, US.
- 2012. miR-19a: potential biomarker for metastatic inflammatory breast cancer (IBC). Invited. Collaborative Workshop – Morgan Welch Inflammatory Breast Cancer Research Program and Clinic. Houston, TX, US.
International Presentations
- 2014. microRNA signature as prognostic and predictive biomarker in ESCC patients treated with definitive chemo-radiotherapy (dCRT). Conference. Global Academic Program - Sister Institution Network Fund Grants (SINF). Seoul, KR.
- 2013. Prognostic value of serum miR-19a in patients with HER2+ metastatic inflammatory Breast Cancer (IBC). Invited. 5th International Symposium - Primary Systemic Treatment in the Management of Operable Breast Cancer. Cremona, IT.
Grant & Contract Support
| Date: | 2024 - 2026 |
| Title: | The role of androgens in regulating extracellular vesicle secretion and molecular cargo loading by prostate cancer cells |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-I |
| ID: | HT9425-23-PCRP-IDA |
| Date: | 2023 - 2025 |
| Title: | Engineered Extracellular Vesicles to Modulate Immunotherapy in Liver Cancer |
| Funding Source: | Society of Interventional Oncology - AstraZeneca |
| Role: | Co-PI |
| Date: | 2021 - 2024 |
| Title: | Effect of Catecholamine Signaling on the Secretion and Cargo of Extracellular Vesicles in Peritoneal Carcinomatosis |
| Funding Source: | The G. Harold and LeilaY Mathers Foundation |
| Role: | Co-I |
| ID: | MF-2012-01275 |
| Date: | 2021 - 2023 |
| Title: | Hormone Regulation of Tumor Microenvironment in Estrogen Receptor-Positive Breast Cancer by Extracellular Vesicle microRNAs |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-I |
| Date: | 2021 - 2022 |
| Title: | Effect of neuro-endocrine signaling on the secretion and cargo composition of EVs in breast cancer |
| Funding Source: | IRG-UTMDACC |
| Role: | Co-I |
| Date: | 2021 - 2022 |
| Title: | Nicotine and nitrosamine regulation of EV secretion and their miRNA cargo in lung cancer |
| Funding Source: | The Division of Pathology and Laboratory Medicine (DPLM) Funding for Research Projects Instructors |
| Role: | PI |
| Date: | 2014 - 2016 |
| Title: | Tissue microRNA signatures in esophageal squamous cell carcinoma treated by definitive chemoradiotherapy |
| Funding Source: | The University of Texas M. D. Anderson Cancer Center SINF |
| Role: | Key |
Selected Publications
Peer-Reviewed Articles
- Frederico O Gleber-Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Anfossi S, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi-Konefka, Roberto Rangel, Jeffrey N Myers, George A Calin, Moran Amit. β-Adrenergic Signaling Promotes Anti-Tumor Immunity in TP53-mutant Oral Squamous Cell Carcinoma. Adv. Sci. (Weinh), 2026. e-Pub 2026. PMID: 41665072.
- Cohen EN, Gao H, Tin S, Wu Q, Ivan C, Ueno NT, Woodward WA, Reuben JM, Anfossi S. High levels of circulating miR-19a-3p in patients with metastatic HER2 + breast cancer are associated with a favorable prognosis and anti-tumor immune responses. Breast Cancer Res 28(1), 2026. e-Pub 2026. PMID: 41582199.
- Anfossi S, Darbaniyan F, Quinlan J, Calin S, Shimizu M, Chen M, Rausseo P, Winters M, Bogatenkova E, Do KA, Martinez I, Li Z, Antal L, Olariu TR, Wistuba I, Calin G. MicroRNAs are enriched at COVID-19 genomic risk regions, and their blood levels correlate with the COVID-19 prognosis of cancer patients infected by SARS-CoV-2. Mol Cancer 23(1), 2024. e-Pub 2024. PMID: 39434078.
- Dragomir MP, Fuentes-Mattei E, Winkle M, Okubo K, Bayraktar R, Knutsen E, Qdaisat A, Chen M, Li Y, Shimizu M, Pang L, Liu K, Liu X, Anfossi S, Zhang H, Koch I, Tran AM, Mohapatra S, Ton A, Kaplan M, Anderson MW, Rothfuss SJ, Silasi R, Keshari RS, Ferracin M, Ivan C, Rodriguez-Aguayo C, Lopez-Berestein G, Georgescu C, Banerjee PP, Basar R, Li Z, Horst D, Vasilescu C, Bertilaccio MTS, Rezvani K, Lupu F, Yeung SC, Calin GA. Anti-miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response. J Clin Invest 133(14), 2023. e-Pub 2023. PMID: 37261908.
- Drula R, Pardini B, Fu X, De Los Santos MC, Jurj A, Pang L, El-Daly SM, Fabris L, Knutsen E, Dragomir MP, Bayraktar R, Li Y, Chen M, Del Vecchio F, Berland L, Dae J, Fan D, Shimizu M, Tran AM, Barzi M, Pioppini C, Gutierrez AM, Ivan C, Meas S, Hall CS, Alahari SK, Berindan-Neagoe I, Fabbri M, Lucci A, Arun B, Anfossi S, Calin GA. 17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer. Proc Natl Acad Sci U S A 120(23):e2122053120, 2023. e-Pub 2023. PMID: 37252969.
- Untergasser A, Hellemans J, Pfaffl MW, Ruijter JM, van den Hoff MJB, Dragomir MP, Adamoski D, Dias SMG, Reis RM, Ferracin M, Dias-Neto E, Marsh I, Kubista M, Fabbri M, Goel A, Slabý O, Knutsen E, Chen B, Negrini M, Mimori K, Pichler M, Papatriantafyllou M, Anfossi S, Schmittgen TD, Huggett J, Bustin S, Vandesompele J, Calin GA, dIsClosure) Consortium H(IGOQ. Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action. Mol Oncol 17(5):713-717, 2023. e-Pub 2023. PMID: 36916500.
- Moore JA, Lehner MJ, Anfossi S, Datar S, Tidwell RS, Campbell M, Shah AY, Ward JF, Karam JA, Wood CG, Pisters LL, Calin GA, Tu SM. Predictive capacity of a miRNA panel in identifying teratoma in post-chemotherapy consolidation surgeries. BJUI Compass 4(1):81-87, 2023. e-Pub 2023. PMID: 36569509.
- Vicente DA, Schobel SA, Anfossi S, Hensman H, Lisboa F, Robertson H, Khatri V, Bradley MJ, Shimizu M, Buchman TG, Davis TA, Dente CJ, Kirk AD, Calin GA, Elster EA. Cellular microRNAs correlate with clinical parameters in multiple injury patients. J Trauma Acute Care Surg 93(4):427-438, 2022. e-Pub 2022. PMID: 35797620.
- Vicente D, Schobel SA, Anfossi S, Hensman H, Lisboa F, Robertson H, Khatri V, Bradley MJ, Shimizu M, Buchman TG, Davis TA, Dente CJ, Kirk AD, Calin GA, Elster EA. Viral Micro-RNAs Are Detected in the Early Systemic Response to Injury and Are Associated With Outcomes in Polytrauma Patients. Crit Care Med 50(2):296-306, 2022. e-Pub 2022. PMID: 34259445.
- Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA. The Long Noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling. Gastroenterology, 2020. e-Pub 2020. PMID: 32805281.
- Pichler M, Rodriguez-Aguayo C, Nam SY, Dragomir MP, Bayraktar R, Anfossi S, Knutsen E, Ivan C, Fuentes-Mattei E, Lee SK, Ling H, Catela Ivkovic T, Huang G, Huang L, Okugawa Y, Katayama H, Taguchi A, Bayraktar E, Bhattacharya R, Amero P, He WR, Tran AM, Vychytilova-Faltejskova P, Klec C, Bonilla DL, Zhang X, Kapitanovic S, Loncar B, Gafà R, Wang Z, Cristini V, Hanash SM, Bar-Eli M, Lanza G, Slaby O, Goel A, Rigoutsos I, Lopez-Berestein G, Calin GA. Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut 69(10):1818-1831, 2020. e-Pub 2020. PMID: 31988194.
- Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 578(7795):449-454, 2020. e-Pub 2020. PMID: 32051587.
- Mitra K, Feist WN, Anfossi S, Fuentes-Mattei E, Almeida MI, Kim JJ, Calin GA, Warmflash A. S-MiRAGE: A Quantitative, Secreted RNA-Based Reporter of Gene Expression and Cell Persistence. ACS Synth Biol 8(1):25-33, 2019. e-Pub 2019. PMID: 30550267.
- Mego M, Gao H, Cohen EN, Anfossi S, Giordano A, Tin S, Fouad TM, De Giorgi U, Giuliano M, Woodward WA, Alvarez RH, Valero V, Ueno NT, Hortobagyi GN, Cristofanilli M, Reuben JM. Circulating tumor cells (CTCs) are associated with abnormalities in peripheral blood dendritic cells in patients with inflammatory breast cancer. Oncotarget 8(22):35656-35668, 2017. e-Pub 2017. PMID: 27374101.
- Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, Shimizu M, Redis RS, Shah MY, Zhang X, Okugawa Y, Jung EJ, Tsirigos A, Huang L, Ferdin J, Gafà R, Spizzo R, Nicoloso MS, Paranjape AN, Shariati M, Tiron A, Yeh JJ, Teruel-Montoya R, Xiao L, Melo SA, Menter D, Jiang ZQ, Flores ER, Negrini M, Goel A, Bar-Eli M, Mani SA, Liu CG, Lopez-Berestein G, Berindan-Neagoe I, Esteller M, Kopetz S, Lanza G, Calin GA. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biol 18(1):98, 2017. e-Pub 2017. PMID: 28535802.
- Liu S, Anfossi S, Qiu B, Zheng Y, Cai M, Fu J, Yang H, Liu Q, Chen Z, Fu J, Liu M, Burks JK, Lin SH, Reuben J, Liu H. Prognostic Factors for Locoregional Recurrence in Patients with Thoracic Esophageal Squamous Cell Carcinoma Treated with Radical Two-Field Lymph Node Dissection: Results from Long-Term Follow-Up. Ann Surg Oncol 24(4):966-973, 2017. e-Pub 2017. PMID: 27804027.
- Debeb BG, Lacerda L, Anfossi S, Diagaradjane P, Chu K, Bambhroliya A, Huo L, Wei C, Larson RA, Wolfe AR, Xu W, Smith DL, Li L, Ivan C, Allen PK, Wu W, Calin GA, Krishnamurthy S, Zhang XH, Buchholz TA, Ueno NT, Reuben JM, Woodward WA. miR-141-Mediated Regulation of Brain Metastasis From Breast Cancer. J Natl Cancer Inst 108(8), 2016. e-Pub 2016. PMID: 27075851.
- Mego M, Gao H, Cohen EN, Anfossi S, Giordano A, Sanda T, Fouad TM, De Giorgi U, Giuliano M, Woodward WA, Alvarez RH, Valero V, Ueno NT, Hortobagyi GN, Cristofanilli M, Reuben JM. Circulating Tumor Cells (CTC) Are Associated with Defects in Adaptive Immunity in Patients with Inflammatory Breast Cancer. J Cancer 7(9):1095-104, 2016. e-Pub 2016. PMID: 27326253.
- Mego M, Zuo Z, Gao H, Cohen EN, Giordano A, Tin S, Anfossi S, Jackson S, Woodward W, Ueno NT, Valero V, Alvarez RH, Hortobagyi GN, Khoury JD, Cristofanilli M, Reuben JM. Circulating tumour cells are linked to plasma D-dimer levels in patients with metastatic breast cancer. Thromb Haemost 113(3):593-8, 2015. e-Pub 2015. PMID: 25373787.
- Cohen EN, Gao H, Anfossi S, Mego M, Reddy NG, Debeb B, Giordano A, Tin S, Wu Q, Garza RJ, Cristofanilli M, Mani SA, Croix DA, Ueno NT, Woodward WA, Luthra R, Krishnamurthy S, Reuben JM. Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells. PLoS One 10(7):e0132710, 2015. e-Pub 2015. PMID: 26207636.
- Giuliano M, Giordano A, Jackson S, De Giorgi U, Mego M, Cohen EN, Gao H, Anfossi S, Handy BC, Ueno NT, Alvarez RH, De Placido S, Valero V, Hortobagyi GN, Reuben JM, Cristofanilli M. Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination. Breast Cancer Res 16(5):440, 2014. e-Pub 2014. PMID: 25223629.
- Anfossi S, Giordano A, Gao H, Cohen EN, Tin S, Wu Q, Garza RJ, Debeb BG, Alvarez RH, Valero V, Hortobagyi GN, Calin GA, Ueno NT, Woodward WA, Reuben JM. High serum miR-19a levels are associated with inflammatory breast cancer and are predictive of favorable clinical outcome in patients with metastatic HER2+ inflammatory breast cancer. PLoS One 9(1):e83113, 2014. e-Pub 2014. PMID: 24416156.
- Bao Y, Liu S, Zhou Q, Cai P, Anfossi S, Li Q, Hu Y, Liu M, Fu J, Rong T, Li Q, Liu H. Three-dimensional conformal radiotherapy with concurrent chemotherapy for postoperative recurrence of esophageal squamous cell carcinoma: clinical efficacy and failure pattern. Radiat Oncol 8:241, 2013. e-Pub 2013. PMID: 24139225.
- Giordano A, Gao H, Cohen EN, Anfossi S, Khoury J, Hess K, Krishnamurthy S, Tin S, Cristofanilli M, Hortobagyi GN, Woodward WA, Lucci A, Reuben JM. Clinical relevance of cancer stem cells in bone marrow of early breast cancer patients. Ann Oncol 24(10):2515-21, 2013. e-Pub 2013. PMID: 23798614.
- Giordano A, Gao H, Anfossi S, Cohen E, Mego M, Lee BN, Tin S, De Laurentiis M, Parker CA, Alvarez RH, Valero V, Ueno NT, De Placido S, Mani SA, Esteva FJ, Cristofanilli M, Reuben JM. Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. Mol Cancer Ther 11(11):2526-34, 2012. e-Pub 2012. PMID: 22973057.
- Bellone S, Anfossi S, O'Brien TJ, Cannon MJ, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Santin AD. Induction of human tumor-associated differentially expressed gene-12 (TADG-12/TMPRSS3)-specific cytotoxic T lymphocytes in human lymphocyte antigen-A2.1-positive healthy donors and patients with advanced ovarian cancer. Cancer 115(4):800-11, 2009. e-Pub 2009. PMID: 19117353.
- Bellone S, Anfossi S, O'Brien TJ, Cannon MJ, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Santin AD. Generation of CA125-specific cytotoxic T lymphocytes in human leukocyte antigen-A2.1-positive healthy donors and patients with advanced ovarian cancer. Am J Obstet Gynecol 200(1):75.e1-10, 2009. e-Pub 2009. PMID: 18976739.
- Santin AD, Zhan F, Bignotti E, Siegel ER, Cané S, Bellone S, Palmieri M, Anfossi S, Thomas M, Burnett A, Kay HH, Roman JJ, O'Brien TJ, Tian E, Cannon MJ, Shaughnessy J, Pecorelli S. Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 331(2):269-91, 2005. e-Pub 2005. PMID: 15629771.
- Santin AD, Zhan F, Bellone S, Palmieri M, Cane S, Bignotti E, Anfossi S, Gokden M, Dunn D, Roman JJ, O'Brien TJ, Tian E, Cannon MJ, Shaughnessy J, Pecorelli S. Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy. Int J Cancer 112(1):14-25, 2004. e-Pub 2004. PMID: 15305371.
- Santin AD, Cane' S, Bellone S, Bignotti E, Palmieri M, De Las Casas LE, Roman JJ, Anfossi S, O'Brien T, Pecorelli S. The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells. Gynecol Oncol 94(2):283-8, 2004. e-Pub 2004. PMID: 15297163.
- Santin AD, Cane' S, Bellone S, Bignotti E, Palmieri M, De Las Casas LE, Anfossi S, Roman JJ, O'Brien T, Pecorelli S. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. Cancer 98(9):1898-904, 2003. e-Pub 2003. PMID: 14584072.
- Pietra G, Romagnani C, Falco M, Vitale M, Castriconi R, Pende D, Millo E, Anfossi S, Biassoni R, Moretta L, Mingari MC. The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition. Eur J Immunol 31(12):3687-93, 2001. e-Pub 2001. PMID: 11745389.
Invited Articles
- Anfossi S, Calin GA. When non-coding is not enough. J Exp Med 217(3), 2020. e-Pub 2020. PMID: 32023341.
- Anfossi S, Calin GA. Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy. Cancer Drug Resist 3(3):356-370, 2020. e-Pub 2020. PMID: 33062956.
- Anfossi S, Calin GA. Hodgkin Lymphoma Cells Have a Specific Long Noncoding RNA Expression Pattern. Am J Pathol 186(9):2251-3, 2016. e-Pub 2016. PMID: 27456130.
- Anfossi S. Identifying Predictive Biomarkers for Immunotherapy: The Need for Minimally Invasive, Inexpensive, Broadly Applicable across Cancer Type, Pharmacodynamic Biomarkers. JCH.
Review Articles
- Dragomir MP, Moisoiu V, Manaila R, Pardini B, Knutsen E, Anfossi S, Amit M, Calin GA. A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment. J Clin Med 9(11), 2020. e-Pub 2020. PMID: 33142779.
- El-Daly SM, Bayraktar R, Anfossi S, Calin GA. The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies. Int J Mol Sci 21(9), 2020. e-Pub 2020. PMID: 32403283.
- Cortez MA, Anfossi S, Ramapriyan R, Menon H, Atalar SC, Aliru M, Welsh J, Calin GA. Role of miRNAs in immune responses and immunotherapy in cancer. Genes Chromosomes Cancer 58(4):244-253, 2019. e-Pub 2019. PMID: 30578699.
- Anfossi S, Babayan A, Pantel K, Calin GA. Clinical utility of circulating non-coding RNAs - an update. Nat Rev Clin Oncol 15(9):541-563, 2018. e-Pub 2018. PMID: 29784926.
- Ravelli A, Reuben JM, Lanza F, Anfossi S, Cappelletti MR, Zanotti L, Gobbi A, Senti C, Brambilla P, Milani M, Spada D, Pedrazzoli P, Martino M, Bottini A, Generali D, European Blood STWPO, Society (EBMT) MT. Breast cancer circulating biomarkers: advantages, drawbacks, and new insights. Tumour Biol 36(9):6653-65, 2015. e-Pub 2015. PMID: 26307395.
- Ravelli A, Reuben JM, Lanza F, Anfossi S, Cappelletti MR, Zanotti L, Gobbi A, Milani M, Spada D, Pedrazzoli P, Martino M, Bottini A, Generali D, European Blood STWPOT, Society (EBMT) MT. Immune-related strategies driving immunotherapy in breast cancer treatment: a real clinical opportunity. Expert Rev Anticancer Ther 15(6):689-702, 2015. e-Pub 2015. PMID: 25927868.
Book Chapters
- Anfossi S, Fu X, Nagvekar R, Calin GA. MicroRNAs, Regulatory Messengers Inside and Outside Cancer Cells. In: Adv Exp Med Biol, 87-108, 2018.
Patents
- George Calin, Philip Jones, Barbara Czako, Anfossi Simone. UREA INHIBITORS OF MICRO-RNA, 2023. Patent Number: US 2023/0145868 A1.
Patient Reviews
CV information above last modified August 25, 2026