Sinchita Roy Chowdhuri, M.D., Ph.D.
Department of Anatomical Pathology, Division of Pathology-Lab Medicine Div
About Dr. Roy Chowdhuri
I am a board certified Cytopathologist and Molecular Pathologist, currently working as an associate professor in the Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center. I completed my residency training in Anatomic Pathology, followed by fellowship trainings in Cytopathology and Molecular Genetic Pathology and joined the staff at MDACC in August 2012. I am currently the Director of Molecular Cytopathology and my main research interests include the application of molecular diagnostics in cytology samples for targeted cancer therapy. I serve as a member on several national committees and as a reviewer for several Pathology journals, and have authored numerous peer-reviewed publications in the field of Pathology.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2005 | University of Illinois, Chicago, IL, USA, PHD, Biological Sciences/Molecular Biology |
| 1998 | University of Calcutta, Calcutta, IND, MD, Medicine and Surgery |
Postgraduate Training
| 2011-2012 | Clinical Fellowship, Molecular Genetics Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY |
| 2010-2011 | Clinical Fellowship, Cytopathology, National Cancer Institute, Bethesda, MD |
| 2007-2010 | Clinical Residency, Anatomic Pathology, National Cancer Institute, Bethesda, MD |
| 2005-2007 | Postdoctoral Research, National Cancer Institute, Bethesda, MD |
Board Certifications
| 2013 | American Board of Pathology, Molecular Genetic Pathology |
| 2011 | American Board of Pathology, Cytopathology |
| 2010 | American Board of Pathology, Anatomic Pathology |
Experience & Service
Academic Appointments
Assistant Professor, Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2018
Selected Publications
Peer-Reviewed Articles
- Sholl LM, Aisner DL, Allen TC, Beasley MB, Cagle PT, Capelozzi VL, Dacic S, Hariri LP, Kerr KM, Lantuejoul S, Mino-Kenudson M, Raparia K, Rekhtman N, Roy-Chowdhuri S, Thunnissen E, Tsao M, Vivero M, Yatabe Y. Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med 140(8):825-9, 2016. e-Pub 2016. PMID: 27195432.
- Ikoma N, Blum M, Chiang YJ, Estrella JS, Roy-Chowdhuri S, Fournier K, Mansfield P, Ajani JA, Badgwell BD. Survival rates in T1 and T2 gastric cancer: A Western report. J Surg Oncol. e-Pub 2016. PMID: 27439746.
- Mihalek AD, Haney C, Merino M, Roy-Chowdhuri S, Moss J, Olivier KN. Exercise-induced haemoptysis as a rare presentation of a rare lung disease. Thorax. e-Pub 2016. PMID: 27272655.
- Roy-Chowdhuri S, Aisner DL, Allen TC, Beasley MB, Borczuk A, Cagle PT, Capelozzi V, Dacic S, da Cunha Santos G, Hariri LP, Kerr KM, Lantuejoul S, Mino-Kenudson M, Moreira A, Raparia K, Rekhtman N, Sholl L, Thunnissen E, Tsao MS, Vivero M, Yatabe Y. Biomarker Testing in Lung Carcinoma Cytology Specimens: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med. e-Pub 2016. PMID: 27081878.
- Goswami RS, Luthra R, Singh RR, Patel KP, Routbort MJ, Aldape KD, Yao H, Dang HD, Barkoh BA, Manekia J, Medeiros LJ, Roy-Chowdhuri S, Stewart J, Broaddus RR, Chen H. Identification of Factors Affecting the Success of Next-Generation Sequencing Testing in Solid Tumors. Am J Clin Pathol 145(2):222-37, 2016. e-Pub 2016. PMID: 27124905.
- Sen S, Kawahara B, Gupta D, Tsai R, Khachatryan M, Roy-Chowdhuri S, Bose S, Yoon A, Faull K, Farias-Eisner R, Chaudhuri G. Role of cystathionine β-synthase in human breast Cancer. Free Radic Biol Med 86:228-38, 2015. e-Pub 2015. PMID: 26051168.
- Janku F, Claes B, Huang HJ, Falchook GS, Devogelaere B, Kockx M, Bempt IV, Reijans M, Naing A, Fu S, Piha-Paul SA, Hong DS, Holley VR, Tsimberidou AM, Stepanek VM, Patel SP, Kopetz ES, Subbiah V, Wheler JJ, Zinner RG, Karp DD, Luthra R, Roy-Chowdhuri S, Sablon E, Meric-Bernstam F, Maertens G, Kurzrock R. BRAF mutation testing with a rapid, fully integrated molecular diagnostics system. Oncotarget 6(29):26886-94, 2015. PMID: 26330075.
- Roy-Chowdhuri S, Goswami RS, Chen H, Patel KP, Routbort MJ, Singh RR, Broaddus RR, Barkoh BA, Manekia J, Yao H, Medeiros LJ, Staerkel G, Luthra R, Stewart J. Factors affecting the success of next-generation sequencing in cytology specimens. Cancer Cytopathol. e-Pub 2015. PMID: 26230354.
- Badgwell B, Roy-Chowdhuri S, Chiang YJ, Matamoros A, Blum M, Fournier K, Mansfield P, Ajani J. Long-term survival in patients with metastatic gastric and gastroesophageal cancer treated with surgery. J Surg Oncol 111(7):875-81, 2015. e-Pub 2015. PMID: 25872485.
- Jardim DL, de Melo Gagliato D, Falchook G, Zinner R, Wheler JJ, Janku F, Subbiah V, Piha-Paul SA, Fu S, Tannir N, Corn P, Tang C, Hess K, Roy-Chowdhuri S, Kurzrock R, Meric-Bernstam F, Hong DS. MET Abnormalities in Patients With Genitourinary Malignancies and Outcomes With c-MET Inhibitors. Clin Genitourin Cancer 13(1):e19-26, 2015. e-Pub 2014. PMID: 25087088.
- Siroy AE, Boland GM, Milton DR, Roszik J, Frankian S, Malke J, Haydu L, Prieto VG, Tetzlaff M, Ivan D, Wang WL, Torres-Cabala C, Curry J, Roy-Chowdhuri S, Broaddus R, Rashid A, Stewart J, Gershenwald JE, Amaria RN, Patel SP, Papadopoulos NE, Bedikian A, Hwu WJ, Hwu P, Diab A, Woodman SE, Aldape KD, Luthra R, Patel KP, Shaw KR, Mills GB, Mendelsohn J, Meric-Bernstam F, Kim KB, Routbort MJ, Lazar AJ, Davies MA. Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma. J Invest Dermatol 135(2):508-15, 2015. e-Pub 2014. PMID: 25148578.
- Goswami RS, Patel KP, Singh RR, Meric-Bernstam F, Kopetz S, Subbiah V, Alvarez RH, Davies MA, Jabbar KJ, Roy Chowdhuri S, Lazar AJ, Medeiros LJ, Broaddus RR, Luthra R, Routbort MJ. Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors. Clin Cancer Res. e-Pub 2015. PMID: 25695693.
- Jardim DL, Tang C, Gagliato Dde M, Falchook GS, Hess K, Janku F, Fu S, Wheler JJ, Zinner RG, Naing A, Tsimberidou AM, Holla V, Li MM, Roy-Chowdhuri S, Luthra R, Salgia R, Kurzrock R, Meric-Bernstam F, Hong DS. Analysis of 1,115 Patients Tested for MET Amplification and Therapy Response in the MD Anderson Phase I Clinic. Clin Cancer Res 20(24):6336-45, 2014. e-Pub 2014. PMID: 25326232.
- *Falk NK, Weissferdt A, Habra MA, Roy-Chowdhuri S. Adrenocorticotropic hormone-producing thymic neuroendocrine carcinoma with oncocytic features: A case report and review of literature. Diagn Cytopathol. e-Pub 2014. PMID: 25354884.
- Roberts NJ, Zhang L, Janku F, Collins A, Bai RY, Staedtke V, Rusk AW, Tung D, Miller M, Roix J, Khanna KV, Murthy R, Benjamin RS, Helgason T, Szvalb AD, Bird JE, Roy-Chowdhuri S, Zhang HH, Qiao Y, Karim B, McDaniel J, Elpiner A, Sahora A, Lachowicz J, Phillips B, Turner A, Klein MK, Post G, Diaz LA, Riggins GJ, Papadopoulos N, Kinzler KW, Vogelstein B, Bettegowda C, Huso DL, Varterasian M, Saha S, Zhou S. Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Sci Transl Med 6(249):249ra111, 2014. PMID: 25122639.
- de Melo Gagliato D, Fontes Jardim DL, Falchook G, Tang C, Zinner R, Wheler JJ, Janku F, Subbiah V, Piha-Paul SA, Fu S, Hess K, Roy-Chowdhuri S, Moulder S, Gonzalez-Angulo AM, Meric-Bernstam F, Hong DS. Analysis of MET Genetic Aberrations in Patients With Breast Cancer at MD Anderson Phase I Unit. Clin Breast Cancer. e-Pub 2014. PMID: 25065564.
- Jardim DL, de Melo Gagliato D, Falchook GS, Janku F, Zinner R, Wheler JJ, Subbiah V, Piha-Paul SA, Fu S, Murphy MB, Ajani J, Tang C, Hess K, Hamilton SR, Roy-Chowdhuri S, Kurzrock R, Meric-Bernstam F, Hong DS. MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit. Oncotarget. e-Pub 2014. PMID: 24742823.
- Kanagal-Shamanna R, Portier BP, Singh RR, Routbort MJ, Aldape KD, Handal BA, Rahimi H, Reddy NG, Barkoh BA, Mishra BM, Paladugu AV, Manekia JH, Kalhor N, Chowdhuri SR, Staerkel GA, Medeiros LJ, Luthra R, Patel KP. Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics. Mod Pathol 27(2):314-27, 2014. e-Pub 2013. PMID: 23907151.
- Jardim DL, Wheler JJ, Hess K, Tsimberidou AM, Zinner R, Janku F, Subbiah V, Naing A, Piha-Paul SA, Westin SN, Roy-Chowdhuri S, Meric-Bernstam F, Hong DS. FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors. PLoS One 9(2):e89388, 2014. e-Pub 2014. PMID: 24586741.
- Erdag, G.,Roy Chowdhuri, S.,Fetsch, P.Erickson, D., Hughes, M. S., Filie, A. C.. KBA.62 and S100 protein expression in cytologic samples of metastatic malignant melanoma. Diagn Cytopathol. e-Pub 2013.
- Chowdhuri SR, Fetsch P, Squires J, Kohn E, Filie AC. Adenocarcinoma cells in effusion cytology as a diagnostic pitfall with potential impact on clinical management: A case report with brief review of immunomarkers. Diagn Cytopathol. e-Pub 2012. PMID: 23161830.
- Tangrea MA, Hipp JD, Armani MD, Hanson JC, Rodriguez-Canales J, Blacklert AR, Roy-Chowdhuri S, Xi L, Raffeld M, O'Flaherty N, Markey SP, Filie AC, Cheng J, Morgan NY, Pohida TJ, Bonner RF, Balis U, Emmert-Buck MR. Advanced microdissection technologies with potential clinical applications. Journal of Molecular Diagnostics 14(6):739, 2012.
- Arcila ME, Chaft JE, Nafa K, Roy-Chowdhuri S, Lau C, Zaidinski M, Paik PK, Zakowski MF, Kris MG, Ladanyi M. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res 18(18):4910-8, 2012. e-Pub 2012. PMID: 22761469.
- Chowdhuri SR, Xi L, Pham TH, Hanson J, Rodriguez-Canales J, Berman A, Rajan A, Giaccone G, Emmert-Buck M, Raffeld M, Filie AC. EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection. Mod Pathol 25(4):548-55, 2012. e-Pub 2011. PMID: 22157931.
- Roy Chowdhuri S, Hanson J, Cheng J, Rodriguez-Canales J, Fetsch P, Balis U, Filie AC, Giaccone G, Emmert-Buck MR, Hipp JD. Semiautomated laser capture microdissection of lung adenocarcinoma cytology samples. Acta Cytol 56(6):622-31, 2012. e-Pub 2012. PMID: 23207440.
- Gill RK, Yang SH, Meerzaman D, Mechanic LE, Bowman ED, Jeon HS, Roy Chowdhuri S, Shakoori A, Dracheva T, Hong KM, Fukuoka J, Zhang JH, Harris CC, Jen J. Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer. Oncogene 30(35):3784-91, 2011. e-Pub 2011. PMID: 21532627.
- Hipp J, Cheng J, Pantanowitz L, Hewitt S, Yagi Y, Monaco J, Madabhushi A, Rodriguez-Canales J, Hanson J, Roy-Chowdhuri S, Filie AC, Feldman MD, Tomaszewski JE, Shih NN, Brodsky V, Giaccone G, Emmert-Buck MR, Balis UJ. Image microarrays (IMA): Digital pathology's missing tool. J Pathol Inform 2:47, 2011. e-Pub 2011. PMID: 22200030.
- Moriyama B, Torabi-Parizi P, Pratt AK, Henning SA, Pennick G, Shea YR, Roy Chowdhuri S, Rinaldi MG, Barrett AJ, Walsh TJ. Pharmacokinetics of liposomal amphotericin B in pleural fluid. Antimicrob Agents Chemother 54(4):1633-5, 2010. e-Pub 2010. PMID: 20086161.
- Hong KM, Yang SH, Chowdhuri SR, Player A, Hames M, Fukuoka J, Meerzaman D, Dracheva T, Sun Z, Yang P, Jen J. Inactivation of LLC1 gene in nonsmall cell lung cancer. Int J Cancer 120(11):2353-8, 2007. PMID: 17304513.
- Roy Chowdhuri S, Crum T, Woollard A, Aslam S, Okkema PG. The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans. Dev Biol 295(2):664-77, 2006. e-Pub 2006. PMID: 16701625.
Invited Articles
- Roy-Chowdhuri S, Stewart J. Preanalytic Variables in Cytology: Lessons Learned From Next-Generation Sequencing-The MD Anderson Experience. Arch Pathol Lab Med. e-Pub 2016. PMID: 27333361.
- Chen H, Luthra R, Goswami RS, Singh RR, Roy-Chowdhuri S. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies. Cancers (Basel) 7(3):1699-715, 2015. e-Pub 2015. PMID: 26343728.
- Luthra R, Chen H, Roy-Chowdhuri S, Singh RR. Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges. Cancers (Basel) 7(4):2023-36, 2015. e-Pub 2015. PMID: 26473927.
- Roy-Chowdhuri S, Krishnamurthy S. The role of cytology in the era of HPV-related head and neck carcinoma. Semin Diagn Pathol. e-Pub 2014. PMID: 25638437.
Manuals, Teaching Aids, Other Teaching Publications
- Singh C, Roy AJ, Roy-Chowdhuri S. Image-based Cytopathology Reference App on iOS “CytoAtlas”, 2014.
Book Chapters
- Singh C, Roy Chowdhuri S. Advances in real time quantitative PCR. In: Clinical applications of PCR. 3rd Edition, 2016.