Sivareddy Kotla, PhD
Department of Cardiology, Division of Internal Medicine
About Dr. Sivareddy Kotla
Dr. Kotla has spent the last decade on the regulation of signal transduction mechanisms in the cardiovascular system. After completing his undergraduate/Master of Sciences in Biotechnology and Ph.D. in Biotechnology (2008-2013) from the Jawaharlal Nehru Technological University- Indian Veterinary Research Institute, India. Much of his doctoral work focused on foot-and-mouth disease virus (FMDV) biology, including vaccine efficacy and immune responses. He undertook his post-doctoral training at the University of Tennessee Health Science Center, Department of Physiology, Tennessee, Memphis (2012 – 2015), studying redox regulation of vascular inflammation and atherosclerosis with Dr. G.N Rao. He was then promoted to junior faculty (Research Instructor) at the University of Tennessee Health Science Center in 2015. In August of 2017, he joined the faculty at The University of Texas MD Anderson Cancer Center at Houston in the Department of Cardiology. With these training experiences and collaborating with Dr. Jun-ichi Abe he has expanded his research through use of transgenic and knock out mouse models to study molecular mechanisms of cardio toxicity associated with cancer treatments. The Kotla’s research uses an integrated approach from molecules, cell-based, metabolism, animal models, mitochondria biology towards these goals.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Cardiology-Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2013 | Indian Veterinary Research Institute - Jawaharlal Nehru Technological University, Bangalore, Hyderabad, IN, Ph.D. in Biotechnology |
| 2005 | Bangalore University, Bangalore, Karnataka, IN, M.S. in Biotechnology |
| 2003 | Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, IN, BS in Microbiology |
Postgraduate Training
| 2017-2023 | Assistant Professor, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2015-2017 | Research instructor, Instructor, University of Tennessee Health Science Center, Memphis, Tennessee |
| 2012-2015 | Postdoctoral Research Trainee, Postdoctoral Research Trainee, University of Tennessee Health Science Center, Memphis, Tennessee |
| 2011-2012 | Senior Research Assistant, University of Tennessee Health Science Center, Memphis, Tennessee |
Experience & Service
Extramural Institutional Committee Activities
Member, MD/PhD program applicant’s interviewer, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, Graduate School of Biomedical Science (GSBS) Admission Committee, The University of Texas MD Anderson Cancer Center, 2025 - Present
Member, DoIM Research Distinguished Paper Award subcommittee, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, DoIM Research Grand rounds, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, DoIM Research Committee, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, IACUC committee, The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, Faculty senate committee, The University of Texas MD Anderson Cancer Center, 2021 - 2025
Member, Academic Planning committee (Faculty senate subcommittee), The University of Texas MD Anderson Cancer Center, 2021 - 2025
Editorial Activities
Guest Editor for special issue -Mechanisms of Cellular Senescence and Inflammation in Cardiovascular Disease, Biomedicines, 2025 - Present
Editorial Board member, Frontiers in Cardiovascular Medicine, 2022 - Present
Associate Editor, Frontiers in Physiology, 2021 - Present
Editor/Service on Editorial Board(s), Frontiers in Physiology, 2020 - Present
Review Editor, Frontiers in Cell and Developmental Biology, 2019 - Present
Editor/Service on Editorial Board(s), Journal of Cardiology and Cardiovascular Diseases, 2018 - Present
Editor/Service on Editorial Board(s), Frontiers in Cardiovascular Medicine, 2018 - Present
Honors & Awards
| 2025 | 2025 – Cyrus Scholar Award, Basic Science Finalist, Division of Internal Medicine (DoIM) Research Retreat, UT MD Anderson Cancer Center |
| 2023 | Distinguished Paper Award Recipient in Basic Science, DoIM- MD AAnderson Cancer Center |
| 2022 | Outstanding Review Editor award, Frontiers in Cardiovascular Medicine |
| 2014 - 2015 | Outstanding Postdoctoral Research Achievement Award, University of Tennessee Health Science Center |
| 2011 | Outstanding Young Biotechnologist Award, SAB India |
| 2010 | Best Paper Presentation Award, Indian Virology Society |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. New approaches in Cardiovasulcar research. Invited. GCC IDR2 Consortium. Houston, Texas, US.
- 2025. Disturbed Flow Downregulates LATS1/2, Driving Endothelial Senescence-Associated Stemness (SAS) and Thromboatherosclerotic Plaque Formation. Invited. DoIM Research Retreat- Cyrus award Basic Science finalist. Houston, Texas, US.
- 2025. Mechanosensitive Hippo-YAP Signaling in Atherothrombosis: From Endothelial Stress to Plaque Instability. Invited. Department Research Seminar. Houston, Texas, US.
- 2023. Role of Telomere and Telomerase in cancer treatment induced pre-mature aging. Invited. Houston, Texas, US.
- 2023. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Invited. DoIM Research Grand rounds. Houston, Texas, US.
- 2018. Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV+ individuals: implications for atherogenesis. Invited. Houston Vascular Biology Group. Houston, Texas, US.
- 2016. Lipoxygenase role in macrophage polarization. Invited. Houston, Texas, US.
- 2016. Lipoxygenase role in Vascular Inflammation. Invited. Chicago, Illlinois, US.
- 2016. Lipoxygenase role in Vascular Inflammation. Invited. Ann Arbor, Michigan, US.
- 2016. Lipoxygenase role in Vascular Inflammation. Invited. Memphis, Tennessee, US.
- 2014. The Transcription Factor CREB enhances the IL-17A production and Inflammation in mouse model of Atherosclerosis. Invited. Memphis, Tenessee, US.
Regional Presentations
- 2023. Decoding ERK5 S496 Phosphorylation : implications for Atherosclerosis and senescence associated stemness. Conference. Gulf Coast Vascular Research Consortium. College station, Texas, US.
- 2019. Cardiotoxic cancer treatment (CTCT) promotes oxidative stress and alters monocyte/ macrophage biology. Conference. Gulf Coast Vascular Research Consortium. Houston, Texas, US.
National Presentations
- 2020. P90rsk-mediated Erk5 S496 Phosphorylation and Poly (adp-ribose) Polymerase (parp) Activation Promote Monocyte/macrophage Priming in Mouse and Cancer Patients After Radiation Therapy (rt). Conference. Annual Conference, US.
- 2020. Poly (adp-ribose) Polymerase (parp) Activation and Mitochondrial Hibernation Induced by P90rsk-mediated Erk5 S496 Phosphorylation Promote Mitochondrial Ros Production in Macrophage. Conference. Annual Conference, US.
- 2019. Cardiotoxic Cancer Treatment (CTCT) Promotes Oxidative Stress and Alters Monocyte/macrophage Biology. Conference. Annual Conference, US.
- 2019. Cardiotoxic cancer treatment (CTCT) promotes oxidative stress and alters monocyte/ macrophage biology. Conference. Cardiotoxic cancer treatment (CTCT) promotes oxidative stress and alters monocyte/ macrophage biology, US.
- 2019. The key role of endothelial SUMOylation in regulating sustained NADPH oxidase activation under disturbed flow: Involvement of feedback loop formed by FAK-SUMOylation. Conference. Annual Conference, US.
- 2018. Monocyte/macrophages are sensitized to secondary oxidative insult by cardiovascular toxic drugs via the p90RSK-ERK5 S496 phosphorylation pathway, aggrandizing atherosclerosis formation. Conference. From Molecular Pathways to Novel Therapeutics, US.
- 2018. Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV+ individuals: implications for atherogenesis. Conference. Annual Conference, US.
- 2018. Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV+ individuals: implications for atherogenesis. Conference. Workshop, US.
- 2018. Monocytes/macrophages are sensitized to secondary oxidative insult by cardiovascular toxic drugs via the p90RSK-ERK5 S496 phosphorylation pathway, aggrandizing atherosclerotic plaque formation. Conference. Annual Conference, US.
- 2016. Reactive Oxygen Species via Activation of Bruton Tyrosine Kinase Mediate Cholesterol Crystals-Induced CD36 Expression and Foam Cell Formation. Conference. Reactive Oxygen Species via Activation of Bruton Tyrosine Kinase Mediate Cholesterol Crystals-Induced CD36 Expression and Foam Cell Formation, US.
- 2015. ROS mediates p300-dependent STAT1interaction with PPARγ in CD36 expression and foam cell formation. Conference. Annual Conference, US.
- 2014. 15(S) Hydroxyeicosatetraenoic Acid Induces Foam Cell formation by Enhancing CD36 Expression via Activation of ROS-Syk-Pyk2 STAT1 signaling. Conference. Annual Conference, US.
- 2010. Cationic Micro Particle (PLG) coated DNA vaccination induces a long-term immune response and protective immunity against foot-and-mouth disease virus. Conference. Virocon Annual Conference, US.
- 2010. Foot-and-Mouth Disease virus Replication in BHK- 21 cells. Conference. Virocon Annual Conference, US.
- 2008. Dose response studies of 1D-pVAC (Secretory Vector construct coated on cationic PLG microparticles against FMDV in guinea pigs. Conference. 77th Annual Conference, US.
International Presentations
- 2025. Mechanosensitive Hippo-YAP Pathway: A Key Regulator in Atherosclerosis Development. Invited. Join the 3rd International Electronic Conference on Biomedicines, US.
- 2025. Senescence-Associated Cardiovascular Dysfunction: From Mechanisms to Therapies. Invited. Department Seminar. Amaravathi,, IN.
- 2020. P90rsk-mediated Erk5 S496 Phosphorylation and Poly (adp-ribose) Polymerase (parp) Activation Promote Monocyte/macrophage Priming in Mouse and Cancer Patients After Radiation Therapy (rt). Conference. ATVB, US.
- 2019. Cardiotoxic Cancer Treatment (CTCT) Promotes Oxidative Stress and Alters Monocyte/macrophage Biology. Conference. REDOX BIOLOGY, US.
- 2018. Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV+ individuals: implications for atherogenesis. Conference. North American Vascular Biology organization, US.
Grant & Contract Support
| Date: | 2026 - 2028 |
| Title: | Stage-Specific Targeting of ALDH2 to Eradicate Leukemia Stem-Like Cells and Prevent T-ALL Relapse |
| Funding Source: | DoD |
| Role: | PI |
| ID: | CA251273 |
| Date: | 2026 - 2030 |
| Title: | The DDIAS-ACLY Complex and Exercise Training in Maintaining Endothelial Homeostasis |
| Funding Source: | NIH/NHLBI |
| Role: | Co-I |
| ID: | 1R01HL181538-01 |
| Date: | 2026 - 2031 |
| Title: | Targeting SARM1-TOP2b Axis to prevent Stress-induced Vascular Aging |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1R01HL185107-01 |
| Date: | 2025 - 2027 |
| Title: | Mitigating Radiation-Induced Cardiovascular Disease with a Novel nano Fullerene Derivative |
| Funding Source: | AHA |
| Role: | PI |
| ID: | 25TPA1458406 |
| Date: | 2025 - 2028 |
| Title: | Metabolomic and Genetic Factors Decoupling Immune Checkpoint Inhibitor Tumor Efficacy and Cardiovascular Toxicity |
| Funding Source: | FDA |
| Role: | Co-I |
| ID: | 1U01FD008717 |
| Date: | 2025 - 2030 |
| Title: | SARM1-TOP2B module in disturbed flow induced endothelial dysfunction |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1R01HL176601-01A1 |
| Date: | 2025 - 2030 |
| Title: | Deciphering the role of GFPT2 in radiation-induced cardiovascular disease |
| Funding Source: | NIH/NHLBI |
| Role: | Co-I |
| ID: | R01HL179815 |
| Date: | 2024 - 2026 |
| Title: | Investigating Metabolic and Senescence-Related Reprogramming in Radiation-Induced Cardiovascular Disease |
| Funding Source: | AHA |
| Role: | PI |
| ID: | 24TPA1301207 |
| Date: | 2024 - 2029 |
| Title: | Persistent BH4 depletion and vascular aging by disturbed flow |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1R01HL169968-01A1 |
| Date: | 2023 - 2025 |
| Title: | Metabolite profile in radiation-induced cardiovascular disease |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R21CA270505-01A1 |
| Date: | 2022 - 2027 |
| Title: | Preamure ageing disorders, metabolites, and athreoslcrosis |
| Funding Source: | NIH/NHLBI |
| Role: | CO-I |
| ID: | 1R01HL163857 |
| Date: | 2022 - 2024 |
| Title: | Metabolite profiling in radiation-induced cardiovascular disease |
| Funding Source: | UT MD Anderson Cancer Center |
| Role: | PI |
| ID: | IRG |
| Date: | 2021 - 2026 |
| Title: | Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy |
| Funding Source: | NIH/NCI |
| Role: | CO-I |
| ID: | 1P01CA261669 |
| Date: | 2021 - 2024 |
| Title: | Risk Factors and Mechanisms of Radiation -Induced Cardiovascular Disease |
| Funding Source: | Multidisciplinary Research Program, MD Anderson Cancer Center |
| Role: | Co-I |
| ID: | UT MD Anderson |
| Date: | 2021 - 2026 |
| Title: | Radiation-induced cardiovascular toxicity and senescence-associated stemness in macrophage |
| Funding Source: | NIH/NHLBI |
| Role: | PI |
| ID: | 1R01CA262446-01 |
| Date: | 2021 - 2026 |
| Title: | Modulation of SENP2-mediated NAD+ depletion in radiation-induced endothelial damage |
| Funding Source: | NIH/NHLBI |
| Role: | Co-PI |
| ID: | 1R01HL159525-01 |
| Date: | 2020 - 2022 |
| Title: | Radiation-induced TET2 degradation and coronary atherosclerosis |
| Funding Source: | AHA |
| Role: | PI |
| ID: | 853457 |
| Date: | 2020 - 2025 |
| Title: | Mitigating radiation-induced cardiovascular disease by inhibiting pre-mature aging |
| Funding Source: | NIH/NIAID |
| Role: | CO-I |
| ID: | U01AI156921 |
| Date: | 2019 - 2021 |
| Title: | Novel role of the positive feedback loop of p90RSK-FAK-SUMOylation in radio-resistance and atherosclerosis after radiation |
| Funding Source: | AHA |
| Role: | PI |
| ID: | 18CDA34060058 |
| Date: | 2019 - 2024 |
| Title: | Pathological flow-induced endothelial damage and plaque erosion |
| Funding Source: | NIH/NHLBI |
| Role: | CO-I |
| ID: | R01HL149303 |
| Date: | 2019 - 2026 |
| Title: | Inducible epithelial resistance: a program investigating mechanisms to protect against acute and chronic complications of pneumonia |
| Funding Source: | NIH/NHLBI |
| Role: | CO-I |
| ID: | R35HL144805 |
| Date: | 2017 - 2023 |
| Title: | A Novel Role of MAGI1 in regulating non-canonical LATS signaling and atherosclerotic plaque formation |
| Funding Source: | NIH/NHLBI |
| Role: | CO-I |
| ID: | R01HL134740 |
| Date: | 2017 - 2021 |
| Title: | cART accelerates vascular aging in HIV infected subjects |
| Funding Source: | NIH/NHLBI |
| Role: | Co-I |
| ID: | NCE, NIH/NHLBI, HL123346 |
| Date: | 2016 - 2021 |
| Title: | Disturbed flow-induced TERF2IP post-translational modifications and atherosclerosis |
| Funding Source: | NIH/NHLBI |
| Role: | CO-I |
| ID: | R01HL130193 |
Selected Publications
Peer-Reviewed Articles
- Dhar, SS, Brown, CA, Rizvi, A, Reed, L, Kotla, S, Zod, C, Abraham, J, Abe, J, Rajaram, V, Chen, K, Lee, MG. Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS. Cell Reports 44(5), 2025. e-Pub 2025. PMID: 40286267.
- Samanthapudi, VS, Kotla, S, Le, NT. TNIK-driven regulation of ERK5 transcriptional activity in endothelial cells. Frontiers in Cardiovascular Medicine 12, 2025. e-Pub 2025. PMID: 40672381.
- Savage H, Pareek S, Lee J, Ballarò R, Conterno Minussi D, Hayek K, Sadullozoda M, Lochmann BS, McQuade JL, LaVoy EC, Marmonti E, Patel H, Wang G, Imanishi M, Kotla S, Abe JI, Schadler KL. Aerobic exercise alters the melanoma microenvironment and modulates ERK5 S496 phosphorylation. Cancer Immunol Res 11(9):1168-1183, 2023. e-Pub 2023. PMID: 37307577.
- Abe JI, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Bojorges AP, Gi YJ, Hobbs BP, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen TH, Gupte AA, Reyes-Gibby C, Yeung SJ, Abe RJ, Olmsted-Davis EA, Krishnan S, Dantzer R, Palaskas NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, Kotla S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Circ Res 133(1):25-44, 2023. e-Pub 2023. PMID: 37264926.
- Nguyen, MT, Imanishi, M, Li, S, Chau, KM, Banerjee, P, Velatooru, LR, Ko, KA, Samanthapudi, VS, Gi, YJ, Lee, LL, Abe, RJ, Fujiwara, E, Deswal, A, Lin, SH, Palaskas, NL, Dantzer, R, Fujiwara, K, Borchrdt, MK, Turcios, EB, Olmsted-Davis, EA, Kotla, S, Cooke, J, Wang, G, Abe, J, Le, NT. Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition. Frontiers in Cardiovascular Medicine 10, 2023. e-Pub 2023. PMID: 37711550.
- Chau, KM, Dominic, A, Davis, EL, Kotla, S, Berrios, ET, Fahim, A, Arunesh, A, Li, S, Zhao, D, Chen, K, Davis, AR, Nguyen, MT, Wang, Y, Evans, S, Wang, G, Cooke, J, Abe, J, Huston, DP, Le, NT. TNIK regulation of interferon signaling and endothelial cell response to virus infection. Frontiers in Cardiovascular Medicine 10, 2023. e-Pub 2023. PMID: 38264262.
- Wang Y, Abe JI, Chau KM, Wang Y, Vu HT, Reddy Velatooru L, Gulraiz F, Imanishi M, Samanthapudi VSK, Nguyen MTH, Ko KA, Lee LL, Thomas TN, Olmsted-Davis EA, Kotla S, Fujiwara K, Cooke JP, Zhao D, Evans SE, Le NT. MAGI1 inhibits interferon signaling to promote influenza A infection. Front Cardiovasc Med 9:791143, 2022. e-Pub 2022. PMID: 36082118.
- Imanishi M, Cheng H, Kotla S, Deswal A, Le NT, Chini E, Ko KA, Samanthapudi VSK, Lee LL, Herrmann J, Xu X, Reyes-Gibby C, Yeung SJ, Schadler KL, Yusuf SW, Liao Z, Nurieva R, Amir ED, Burks JK, Palaskas NL, Cooke JP, Lin SH, Kobayashi M, Yoshimoto M, Abe JI. Radiation therapy induces immunosenescence mediated by p90RSK. Front Cardiovasc Med 9:988713, 2022. e-Pub 2022. PMID: 36426217.
- Banerjee P, Olmsted-Davis EA, Deswal A, Nguyen MT, Koutroumpakis E, Palaskas NL, Lin SH, Kotla S, Reyes-Gibby C, Yeung SJ, Yusuf SW, Yoshimoto M, Kobayashi M, Yu B, Schadler K, Herrmann J, Cooke JP, Jain A, Chini E, Le NT, Abe JI. Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications. J Cardiovasc Aging 2(3), 2022. e-Pub 2022. PMID: 35801078.
- Velatooru LR, Abe RJ, Imanishi M, Gi YJ, Ko KA, Heo KS, Fujiwara K, Le NT, Kotla S. Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells. Free Radic Biol Med 177:404-418, 2021. e-Pub 2021. PMID: 34619327.
- Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox Biol 47:102132, 2021. e-Pub 2021. PMID: 34619528.
- Mahalingam R, Dharmalingam P, Santhanam A, Kotla S, Davuluri G, Karmouty-Quintana H, Ashrith G, Thandavarayan RA. Single-cell RNA sequencing analysis of SARS-CoV-2 entry receptors in human organoids. J Cell Physiol 236(4):2950-2958, 2021. e-Pub 2021. PMID: 32944935.
- Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton J, Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe JI, Le NT. Corrigendum: p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway. Front Cardiovasc Med 8:663486, 2021. e-Pub 2021. PMID: 33681312.
- Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton J, Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe JI, Le NT. p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway. Front Cardiovasc Med 7, 2020. e-Pub 2020. PMID: 33304925.
- Kotla S, Le NT, Vu HT, Ko KA, Gi YJ, Thomas TN, Giancursio C, Lusis AJ, Cooke JP, Fujiwara K, Abe JI. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. Metabolism 100:153962, 2019. e-Pub 2019. PMID: 31476350.
- Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe JI. Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein. JCI Insight 4(9), 2019. e-Pub 2019. PMID: 31045573.
- Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT. MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight 4(7), 2019. e-Pub 2019. PMID: 30944250.
- Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI. Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. Circulation 139(9):1199-1216, 2019. e-Pub 2019. PMID: 30586719.
- Ko KA, Wang Y, Kotla S, Fujii Y, Vu HT, Venkatesulu BP, Thomas TN, Medina JL, Gi YJ, Hada M, Grande-Allen J, Patel ZS, Milgrom SA, Krishnan S, Fujiwara K, Abe JI. Developing a Reliable Mouse Model for Cancer Therapy-Induced Cardiovascular Toxicity in Cancer Patients and Survivors. Front Cardiovasc Med 5:26, 2018. e-Pub 2018. PMID: 29675417.
- Vu HT, Kotla S, Ko KA, Fujii Y, Tao Y, Medina J, Thomas T, Hada M, Sood AK, Singh PK, Milgrom SA, Krishnan S, Fujiwara K, Le NT, Abe JI. Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation. Front Cardiovasc Med 5:23, 2018. e-Pub 2018. PMID: 29594152.
- Paez-Mayorga J, Chen AL, Kotla S, Tao Y, Abe RJ, He ED, Danysh BP, Hofmann MC, Le NT. Ponatinib Activates an Inflammatory Response in Endothelial Cells via ERK5 SUMOylation. Front Cardiovasc Med 5:125, 2018. e-Pub 2018. PMID: 30238007.
- Kotla S, Singh NK, Kirchhofer D, Rao GN. Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking. J Biol Chem 292(36):14885-14901, 2017. e-Pub 2017. PMID: 28724635.
- Kotla, S, Singh, NK, Rao, GN. ROS via BTK-p300-STAT1-PPARγ signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation. Redox Biology 11:350-364, 2017. e-Pub 2017. PMID: 28040583.
- Kotla S, Sanghratna Vishanath B, H J D, K G, V V S S, Reddy GR. DNA vaccine (P1-2A- 3C pCDNA) co-administered with Bovine IL-18 gives protective immune response against Foot and Mouth Disease in cattle. Vet Microbiol 193:106-15, 2016. e-Pub 2016. PMID: 27599937.
- Janjanam J, Chandaka GK, Kotla S, Rao GN. PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration. Mol Biol Cell 26(25):4589-606, 2015. e-Pub 2015. PMID: 26490115.
- Singh NK, Kotla S, Kumar R, Rao GN. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling. EBioMedicine 2(11):1767-1784, 2015. e-Pub 2015. PMID: 26870802.
- Singh NK, Kotla S, Dyukova E, Traylor JG, Orr AW, Chernoff J, Marion TN, Rao GN. Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E- deficient mice. Nat Commun 6:7450, 2015. e-Pub 2015. PMID: 26104863.
- Kotla, S, Singh, NK, Traylor, JG, Orr, AW, Rao, GN. ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation. Free Radical Biology and Medicine 76:147-162, 2014. e-Pub 2014. PMID: 25152235.
- Kotla S, Singh NK, Heckle MR, Tigyi GJ, Rao GN. The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis. Sci Signal 6(293):ra83, 2013. e-Pub 2013. PMID: 24045154.
- Singh NK, Kundumani-Sridharan V, Kumar S, Verma SK, Kotla S, Mukai H, Heckle MR, Rao GN. Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1- CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling. J Biol Chem 287(43):36291-304, 2012. e-Pub 2012. PMID: 22893700.
- Kotla S, Rashmi BR, Dechamma HJ, Gopalakrishna S, Banumathi N, Suryanarayana VV, Reddy GR. Cationic micro particle [poly (D,L-lactide-co-glycolide)]-coated DNA vaccination induces a long-term immune response against foot and mouth disease in guinea pigs. J Gene Med 14(5):348-52, 2012. e-Pub 2012. PMID: 22438260.
- Jadav SK, Kotla S, Rashmi BR, Dechamma HJ, Ganesh K, Suryanarayana VV, Reddy GR. Improved immune response by ID-pVAC: a secretory DNA vaccine construct delivered by PLG micro particles against foot and mouth disease in guinea pigs. Res Vet Sci 91(1):86-9, 2011. e-Pub 2011. PMID: 20884037.
- Kotla S, Rao DM, Dechamma HJ, Suryanarayana VV, Reddy GR. Expression of bovine (Bos indicus) interleukin-18 in Escherichia coli and its biological activity. Microbiol Immunol 54(9):564-7, 2010. e-Pub 2010. PMID: 20840156.
- Kotla S, Muralidhar Rao D, Badrinaryana N, Suryanaryana VV, Reddy GR. Enhancement of DNA vaccine (P12A3C-pcDNA) efficacy against foot-and-mouth disease by co administration of interleukin-18-expressing (IL18 pcDNA) plasmid in guinea pigs. FEMS Immunol Med Microbiol 60(3):261-268, 2010. e-Pub 2010. PMID: 21039923.
Review Articles
- Abe, J, Chau, KM, Mojiri, A, Wang, G, Oikawa, M, Samanthapudi, VS, Osborn, AM, Ostos-Mendoza, KC, Mariscal-Reyes, KN, Mathur, T, Jain, A, Herrmann, J, Yusuf, SW, Krishnan, S, Deswal, A, Lin, SH, Kotla, S, Cooke, J, Le, NT. Impacts of Radiation on Metabolism and Vascular Cell Senescence. Antioxidants and Redox Signaling 43(1-3):92-114, 2025. e-Pub 2025. PMID: 40233257.
- Casso-Chapa, B, Vazquez González, NA, Le, NT, Palaskas, NL, Nead, KT, Eutsey, LP, Samanthapudi, VS, Osborn, AM, Lee, J, Mejia, G, Hoang, ON, Lin, SH, Deswal, A, Herrmann, J, Wang, G, Kirkland, J, Krishnan, S, Wehrens, XH, Chini, EN, Yusuf, SW, Iliescu, C, Jain, A, Burks, JK, Seeley, EH, Lorenzi, PL, Chau, KM, Ostos-Mendoza, KC, Grumbach, IM, Brookes, PS, Hanssen, NM, de Winther, M, Yvan-Charvet, L, Kotla, S, Schadler, KL, Abe, J. Reevaluating Anti-Inflammatory Therapy. Arteriosclerosis, thrombosis, and vascular biology 45(3):372-385, 2025. e-Pub 2025. PMID: 39817327.
- Banerjee, P, Chau, KM, Kotla, S, Davis, EL, Turcios, EB, Li, S, Pengzhi, Z, Wang, G, Kolluru, GK, Jain, A, Cooke, J, Abe, J, Le, NT. A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease. Current atherosclerosis reports 26(9):463-483, 2024. e-Pub 2024. PMID: 38958925.
- Banerjee P, Rosales JE, Chau K, Nguyen MTH, Kotla S, Lin SH, Deswal A, Dantzer R, Olmsted-Davis EA, Nguyen H, Wang G, Cooke JP, Abe JI, Le NT. Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors. Front Cardiovasc Med 10:1186679, 2023. e-Pub 2023. PMID: 37332576.
- Jain, A, Casanova, D, Padilla, AV, Paniagua Bojorges, A, Kotla, S, Ko, KA, Samanthapudi, VS, Chau, KM, Nguyen, MT, Wen, J, Hernandez Gonzalez, SL, Rodgers, SP, Olmsted-Davis, EA, Hamilton, DJ, Reyes-Gibby, CC, Yeung, SJ, Cooke, J, Herrmann, J, Chini, EN, Xu, X, Yusuf, SW, Yoshimoto, M, Lorenzi, PL, Hobbs, BP, Krishnan, S, Koutroumpakis, E, Palaskas, NL, Wang, G, Deswal, A, Lin, SH, Abe, J, Le, NT. Premature senescence and cardiovascular disease following cancer treatments. Frontiers in Cardiovascular Medicine 10, 2023. e-Pub 2023. PMID: 37781317.
- Banerjee P, Kotla S, Reddy Velatooru L, Abe RJ, Davis EA, Cooke JP, Schadler K, Deswal A, Herrmann J, Lin SH, Abe JI, Le NT. Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer. Front Cardiovasc Med 8:763930, 2021. e-Pub 2021. PMID: 34746270.
Abstracts
- Ko KA, Kotla S, Abe J. Lats1/2 Expression Reduced By The Pathological Flow Triggers Intraplaque Hemorrhage And Distal Pulmonary Thrombosis By Promoting EC Apoptosis And Proliferation In Concert. ATVB, 2023. e-Pub 2023.
- Kotla S, Zhang A, Imanishi M, Ko KA, Lin S, Deswal A, Le NT, Abe JI. NAD+ depletion-induced vascular senescence via p90RSK-ERK5 S496 phosphorylation. Cell Symposia: Metabolites in Signaling and Disease, 2022. e-Pub 2022.
- Velatooru LR, Abe RJ, Imanishi M, Gi YJ, Heo KS, Fujiwara K, Abe JI, Le NT, Kotla S. Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells. Society for Redox Biology and Medicine. SFRBM, 2021. e-Pub 2021.
- Ko KA, Imanishi M, Gi YJ, Kotla S, Fujiwara K, Abe JI. Novel Model Of Ionizing Radiation-induced Mouse Coronary Arteriosclerosis, Which Was Attenuated By Precise Time Treatment Of Poly (adp-ribose) Polymerase (parp) Inhibito. ATVB, 2021. e-Pub 2021.
- Imanishi M, Ko KA, Kotla S, Thomas TN, Gi YJ, Wang Y, Fujiwara K, Savage H, Velatooru LR, Schadler KL, Shen YH, Le NT, Burks JK, and Abe JI. Novel simultaneous multiplexed imaging with subcellular resolution by mass cytometry (Imaging mass cytometry: IMC) in atherosclerosis plaque (AS). ATVB, 5/2020. ATVB, 2020. e-Pub 2020.
- Banerjee P, Velatooru LR, Imanishi M, Ko KA, Heo K, Kotla S, Giancursio C, McBeath E, Fujiwara K, Thomas TN, Morales E, Abe J, Le N. Laminar Flow-induced Senp2 S344 Phosphorylation Inhibits Endothelial Senescence and Atherosclerosis via Repressing Terf2ip Sumoylation. ATVB, 2020. e-Pub 2020.
- Vu HT, Heo K, Imanishi M, Ko KA, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le N, Abe J, Kotla S. The Key Role of Endothelial Sumoylation in Regulating Sustained Nadph Oxidase Activation Under Disturbed Flow: Involvement of Feedback Loop Formed by Fak-sumoylation. ATVB, 2019. e-Pub 2019.
- Abe J, KotlaS. Disturbed Flow Instigates Endothelial Senescence‒associated Secretory Phenotype (SASP) and Atherogenesis by Inducing Phosphorylation of Telomeric Repeat Binding Factor 2 (TRF2)‒interacting Protein (TERF2IP). 83rd Annual Scientific Meeting of the Japanese Circulation Society, Yokohama, Japan, 2019. e-Pub 2019.
- Paez-Mayorga J, Wang Y, Kotla S, Abe J, Le N. A Novel Role for MAGI1 in Disturbed Flow-Induced Endoplasmic Reticulum Stress in Endothelial Cells. Circulation -AHA, 2018. e-Pub 2018.
- Janjanam J, Chandaka GK, Kotla S, Rao GN. PLCβ3 Mediates Cortactin Interaction with WAVE2 in MCP1-induced Actin Polymerization and Cell Migration. FASEB, 2016. e-Pub 2016.
- Kotla S, Rao GN. ROS mediates p300-dependent STAT1interaction with PPARγ in CD36 expression and foam cell formation. NAVBO, 2015. e-Pub 2015.
- Kotla S, Rashmi BR, Kumar A, Dechamma HJ, Bhanumathi N, Suryanarayana VVS, GR. Reddy Cationic Micro Particle (PLG) coated DNA vaccination Induces a long-term immune response and Protective Immunity against Foot-and-Mouth disease virus. Virocon 2010 Annual conference of Indian Virology Society at Sri Venkateswara University, Tirupathi, India, 2008. e-Pub 2008.
- Kotla S. Alleviating radiation-induced cardiovascular disease with a radioprotective fullerene derivative. ATVB-2025.
- Kotla S. Organized Thrombus (OTh) Formation Mediated by Disturbed Flow-Induced Endothelial Senescence-Associated Stemness (SAS). AHA-2023.
- Kotla S. CD38 Activation by Disturbed Flow (d-flow) Promotes Endothelial Cell (EC) Senescence-Associated Stemness (SAS) through Glutaminolysis Enhanced by Pyruvate Dehydrogenase (PDH) Inhibition, Leading to Atherothrombosis. AHA-2024.
- Kotla S. Disturbed Flow (d-flow)-induced Endothelial Senescence-Associated Stemness (SAS): Unveiling the Impact of CD38 and LATS1/2 Depletion on Atherothrombosis Development. AHA-2024.
- Kotla S. Endothelial Senescence and Stemness Induced by Disturbed Flow: The Role of CD38 and LATS1/2 in Atherothrombosis Development. SFRBM-2024.
- Kotla S. Disturbed Flow Downregulates LATS1/2, Driving Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Plaque Formation. Biomechanics in Vascular Biology and Disease-Gordon conference.
- Kotla S. Alleviating radiation-induced cardiovascular disease with a radioprotective fullerene derivative. AHA-2025.
- Purushotam P, Kotla S, Jayapal-Gowd B. In vitro Regeneration studies in Stevia rebaudiana. International Seminar on Medicinal plants and herbal products 2008.
- Savage H, Pareek S, Lee J, Ballaro R, Samanthapudi V, Ko KA, Imanishi M, Kotla S, Abe JI, Schadler K. Aerobic exercise suppresses melanoma tumor growth via upregulating ERK5 S496 phosphorylation. AACR 2022.
- Wang Y, Vu HT, Velatooru LR, Wang Y, Thomas TN, Imanishi M, Kotla S, Le NT, Fujiwara K, Evans SE, Abe JI. Influenza A virus infection increases MAGI1 expression in endothelial cells and its depletion inhibits virus replication through increased expression of MX1. ATVB 2022.
- Abe J, KotlaS. Disturbed Flow Instigates Endothelial Senescence‒associated Secretory Phenotype (SASP) and Atherogenesis by Inducing Phosphorylation of Telomeric Repeat Binding Factor 2 (TRF2). 83rd Annual Scientific Meeting of the Japanese Circulation Society.2019.
- Kotla S, Rashmi BR, Dechamma HJ, Banumathi N, Suryanarayana VVS, Reddy GR. Dose responses studies of 1 D –pVAC (Secretory Vector construct coated on cationic PLG micro particles against FMDV in guinea pigs. 77th annual conference of Society of biological Chemists (SBC) . 2008.
- Vu HT, Kotla S, Ko KA, Fujii Y, Tao Y, Medina J, Thomas TN, Hada M, Sood AK, Singh PK, Milgrom SA, Krishnan S, Fujiwara K, Le NT, and Abe J. Ionizing radiation induces endothelial inflammation and apoptosis via p90RSK-mediated ERK5 S496 phosphorylation. ATVB. 2018 May 01.
- Ko KA, Kotla S, Wang Y, Fujii Y, Vu HT, Venkatesulu BP, Thomas TN, Medina J, YJ1 G, Hada M, Grande-Allen J, Patel ZS, Milgrom SA, Kirshnan S, Fujiwara K, and Abe J. Radiation induced atherosclerosis on mice. ATVB. 2018.
- Imanishi M, Ko KA, Wang Y, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le NT, Kotla S, and Abe J. Disturbed Flow-induced Endothelial Senescence, But Not Inflammation, Plays A Major Role In Plaque Formation Mediated By Telomeric Repeat Binding Factor 2-interacting Protein (TERF2IP) K240 SUMOylation. ATVB. 2019.
- Kotla S, Zhang A, Imanishi M, Ko KA, Lin S, Deswal A, Le NT, Abe JI. NAD+ depletion-induced vascular senescence via p90RSK-ERK5 S496 phosphorylation Cell Symposia. Metabolites in Signaling and Disease. 2022 Jan 01.
- Vu HT, Heo KS, Imanishi M, Ko KA, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le NT, Abe J, Kotla S. The key role of endothelial SUMOylation in regulating sustained NADPH oxidase activation under disturbed flow: Involvement of feedback loop formed by FAK-SUMOylation. ATVB. 2019.
- Kotla S, Singh NK, Rao GN. Reactive Oxygen Species via Activation of Bruton Tyrosine Kinase Mediate Cholesterol Crystals-Induced CD36 Expression and Foam Cell Formation. SFRBM 2016.
- Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Palaskas NL, Schadler KL, Yusuf SW, Cooke JP, McBeath E, Guptae A, Krishnan S, Deswal A, Brookes PS, Fujiwara K, Burks JK, Le NT, Hamilton DJ, Abe JI. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. NAVBO. 2021.
- Kotla S, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen THM, Gupte AA, Reyes-Gibby C, Yeung SCJ, Palaska NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, and Abe JI. ERK5 S496 Phosphorylation, but Not Erk5 Kinase Activation, Promotes Senescence-Associated Cell Growth (sacg) and Inflammation of Myeloid Cells and Atherosclerosis via Upregulating Sumoylation at a Novel Site (k518) on Nrf2 and Aryl Hydrocarbon Receptor. AHA 2022.
- Kotla S, Ko KA, Abe J. TERF2IP S205Phosphorylation Instigates Pathological Flow-induced Plaque Erosion By Reducing LATS1/2Expression. ATVB. 2023 May 01.
- Pradhan, Kotla S, Kakoli A, Satish G, Dechamma HJ, Bhanumathi N, Reddy GR, Suryanarayana VVS. Immunological evaluation of self-replicating DNA vaccine (constructed for humoral response) carrying ID gene of three FMDV Serotypes in Guinea Pigs. Indian Virology Society 2010.
- Kotla S, Singh NK, Gadiparthi N. 15(S) Hydroxyeicosatetraenoic Acid Induces Foam Cell formation by Enhancing CD36 Expression via Activation of ROS-Syk-Pyk2 STAT1 signaling. ATVB 2014.
- Kotla S, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen THM, Gupte AA, Reyes-Gibby C, Yeung SCJ, Palaska NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, and Abe JI. ERK5 S496 Phosphorylation, but Not Erk5 Kinase Activation, Promotes Senescence-Associated Cell Growth (sacg) and Inflammation of Myeloid Cells and Atherosclerosis via Upregulating Sumoylation at a Novel Site (k518) on Nrf2 and Aryl Hydrocarbon Receptor. SFRBM 2022.
- Ko KA, Kotla S, Abe J. Lats1/2 Expression Reduced By The Pathological Flow Triggers Intraplaque Hemorrhage And Distal Pulmonary Thrombosis By Promoting EC Apoptosis And Proliferation. ATVB. 2023 May 01.
- Janjanam J, Chandaka GK, Kotla S, Rao GN. PLC Mediates Cortactin Interaction with WAVE2 in MCP1-induced Actin Polymerization and Cell Migration. FASEB. 2016.
- Kotla S, Zhang A, Ko KA, Imanishi M, Fujiwara K, Yoon Y, Brooks PS, Hamilton D, and Abe JI. Poly (ADP-ribose) polymerase (PARP) activation and mitochondrial hibernation induced by p90RSK-mediated ERK5 S496 phosphorylation promote mitochondrial ROS production in macrophage. IVBM. 2020.
- Hansen L, Kotla S, Mari G, Rao GN. The Role of NALP3 inflammasome in preeclampsia- a translational approach. American Journal of Obstetrics & Gynecology. 2014.
- Paez-Mayorga J, Wang Y, Kotla S, Abe J, Le N. Disturbed Flow-Induced Endoplasmic Reticulum Stress in Endothelial Cells. AHA. 2018.
- Kotla S, Imanishi M, Li S, Ko KA, Samanthapudi VSK, Savage H, Schadler KL, Shen YH, Deswal A, Lin SH, Reyes-Gibby C, Yeung SCJ, Pownall HJ, Fujiwara K, Burks JK, Le NT, Wang G, and Abe JI. ERK5 S496 phosphorylation, but not ERK5 kinase or transcriptional activity, is responsible for promoting macrophage inflammation and mitochondrial dysfunction via upregulating novel site of NRF2 K518 SUMOylation. ATVB 2022.
- Velatooru LR, Abe RJ, Imanishi M, Gi YJ, Heo KS, Fujiwara K, Abe JI, Le NT, Kotla S. Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells. SFRBM. 2021.
- Kotla S, Ko KA, Imanishi M, Banchs J, Palaskas NL, Yusuf SW, Fujiwara K, Le NT, Anita Deswal A, Chung C, Lin SH, and Abe JI. p90RSK-mediated ERK5 S496 phosphorylation and Poly (ADP-ribose) polymerase (PARP) activation promote monocyte/macrophage priming in mouse and cancer patients after radiation therapy (RT). ATVB. 2020.
- Kotla S, Rao GN. ROS mediates p300-dependent STAT1interaction with PPARγ in CD36 expression and foam cell formation. NAVBO. 2015.
- SammerNJadav, Kotla S, Rashmi BR, Dechamma HJ, ReddyGR A. Improved immune response by ID-pVAC: A secretory DNA vaccine construct delivered by PLG micro particles against foot and mouth disease in guinea pigs. 34th annual conference of the Indian Immunology Society (IIS) a 2007.
- Imanishi M, Ko KA, Wang Y, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Fujiwara K, Le NT, Kotla S, Abe JI. TERF2IP-K240R mutation suppresses D-flow- induced Endothelial cell senescence via suppressing DNA damage response. ATVB. 2021.
- Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Palaskas NL, Schadler KL, Milgrom SA, Banchs J, Yusuf SW, Amata D, Guo H, Thomas TN, Shen YH, Herrmann J, Kleinerman ES, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Guptae A, Krishnan S, Patel ZS, Yoon Y, Brookes PS, Fujiwara K, Burks JK, Le NT, Hamilton DJ, Abe JI, Chung C. Monocyte and macrophage priming and cardiovascular injury from radiation exposure: potential role of PARP activation. NASA Human Research Program Investigator’s Workshop. 2021.
- Ko KA, Imanishi M, Gi YJ, Kotla S, Fujiwara K, Abe JI. Novel Model Of Ionizing Radiation-induced Mouse Coronary Arteriosclerosis, Which Was Attenuated By Precise Time Treatment Of Poly (adp-ribose) Polymerase (parp) Inhibiton. ATVB. 2021.
- Imanishi M, Cheng H, Kotla S, Lin SH, Deswal A, Ko KA, Samanthapudi VSK, Le NT, Fujiwara K, Liao Z, Palaskas N, Yusuf SW, Nurieva R, Reyes-Gibby C, Yeung SCJ, Amir ED, Burks JK, Kobayashi M, Yoshimoto M, Abe JI. Multiparameter mass cytometry reveals the unique response of naïve B cell CD27- subset with the increase of T-bet and CD38 expression after radiation therapy in thoracic cancer patients. ATVB 2022.
- Abe J, KotlaS. Cardiovascular toxic cancer treatments (CTCT) prime monocyte and macrophages to oxidative stress and accelerate atherogenesis. 83rd Annual Scientific Meeting of the Japanese Circulation Society,.
- Kotla S, Le NT, Singh MV, Ko KA, Heo KS, Fujii Y, Vu HT, McBeath E, Thomas TN, Tao Y, Medina J, Stirpe NE, Lu W, Tyrell A, Gates KJ, Qui X, Fujiwara K, Maggirwar SJ, Schifitto G, Abe J. Monocyte/macrophages are sensitized to secondary oxidative insult by cardiovascular toxic drugs via the p90RSK-ERK5 S496 phosphorylation pathway, aggrandizing atherosclerosis formation. Keystone Symposia. 2018.
- Chau K, Imanishi M, Ko KA, Mcbeath E Fujiwara K, Jin Y, Heo K JCheng Thomas T, Schadle KL, Gupte AA, Shen YH, Lin S, Yeh ET, Zuo Y, Sharma A, SLi, Kotla S, Turcios E, Abe RJ, Zhang A, Hamilton D, Cooke JP, Wang G, AbeJI, Le NT. Terf2ip K240 Sumoylation Drives Endothelial Senescence and Atherogenesis via Activating Parp1. AHA 2022.
- Fujii Y, Vu HT, Kolta S, Ko KA, Wang Y, Thomas TN, Heo KS, Le NT, Fujiwara K, Abe J. Disturbed flow-induced TERF2IP K240 SUMOylation is critical for endothelial senescence but not inflammation. ATVB. 2018.
- Kotla S, Kko, Abe J. TERF2IP S205Phosphorylation Instigates Pathological Flow-induced Plaque Erosion By Reducing LATS1/2Expression-2023. Biomechanics in Vascular Biology and Disease Gordon Research Conference. 2023 Aug 01.
- Kotla S, Rashmi BR, Ahmed K, Dechamma HJ, Bhanumathi N, Suryanarayana VVS, Reddy GR. Bovine Interleukin -18 inhibits Foot-and-Mouth Disease virus Replication in BHK- 21 cells. Indian Virology Society 2010.
- Kotla S, Le NT, Singh MV, Ko KA, Heo KS, Fujii Y, Vu HT, McBeath E, Thomas TN, Tao Y, Medina J, Stirpe NE, Lu W, Tyrell A, Gates KJ, Qui X, Fujiwara K, Maggirwar SJ, Schifitto G, and Abe J. Monocyte/macrophages are sensitized to secondary oxidative insult by cardiovascular toxic drugs via the p90RSK-ERK5 S496 phosphorylation pathway, aggrandizing atherosclerosis formation. ATVB. 2018.
- Lin SH, Palaskas N, Gladish G, Fang P, Kotla S, Yusuf S, Milgrom S, Gandhi BS, Slack DR, Abe JI, Chung CC. Pilot study of imaging and serum biomarkers to predict and identify early cardiac injury from radiation exposure.
- Vu HT, Kotla S, Wang Y, Ko KA, Heo KS, Fujii Y, Thomas TN, Gi YJ, Medina J, Fujiwara K, Le NT, and Abe J. Disturb flow induces p90RSK activation in endothelial cell, which increases TERF2IP phosphorylation causing endothelial cell dysfunction. ATVB, 2018 .
- Kotla S, Zhang A, Ko KA, Imanishi M, Mazhar H, Thomas TN, Gi YJ, Vu HT, McBeath E, Lin SH, Palaskas NL, Banchs J, Kleinerman ES, Schadler KL, Fujiwara K, Le NT, Hamilton D, Krishnan S, Abe J. Cardiovascular toxic cancer treatments (CTCT) prime monocyte and macrophages to oxidative stress and accelerate atherogenesis. ATVB. 2019.
- Kotla S, BR Rashmi BR, Kumar A, HJ Dechamma HJ, N Bhanumathi N, VVS Suryanarayana VVS, GR Reddy GR. Cationic Micro Particle (PLG) coated DNA vaccination Induces a long-term immune response and Protective Immunity against Foot-and-Mouth disease virus. Indian Virology Society 2010.
- Banerjee P, Velatooru LR, Imanishi M, Ko KA, Heo K, Kotla S, Giancursio C, McBeath E, Fujiwara K, Thomas TN, Morales E, Nhat-Tu Le JAA. Laminar Flow-induced Senp2 S344 Phosphorylation Inhibits Endothelial Senescence and Atherosclerosis via Repressing Terf2ip Sumoylati. ATVB. 2020.
- Kotla S, Zhang A, Ko KA, Imanishi M, Fujiwara K, Yoon Y, Brookes PS, Hamilton D, and Abe JI. Poly (ADP-ribose) polymerase (PARP) activation and mitochondrial hibernation induced by p90RSK-mediated ERK5 S496 phosphorylation promote mitochondrial ROS production in macrophage. ATVB. 2020.
- Nguyen MTH, Imanishi M, Li S, Ko KA, Banerjee P, Velatooru LR, McBeath E, Fujiwara K, Kotla S, Chau K, Abe R, Borchardt MK, Yeh ET, Cooke JP, Wang G, Abe J, and Le NT. Checkpoint Kinase 1-Associated Senp2 S344 Phosphorylation Under Laminar Flow Attenuates Endothelial-Mesenchymal Transition and Atherogenesis. AHA 2022.
Web Publications
- Abe J, Kotla S, Ko KA, Hamilton DJ. CV Toxicity and Mitochondrial Dysfunction: Why Younger Hearts Are at Risk, 2020.
Patient Reviews
CV information above last modified January 05, 2026