Theocharis Panaretakis, Ph.D.
Department of Genitourinary Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Division of Institute of Environmental Medicine, Karolinska Institutet, Stockholm
Education & Training
Degree-Granting Education
| 2003 | Karolinska Institutet, Solnavagen, USA, PHD, Experimental Oncology |
| 1997 | University of Sussex, Falmer, GBR, BS, Biochemistry |
Postgraduate Training
| 2006-2008 | Research Fellowship, Institut Gustave Roussy, Villejuif |
| 2004-2006 | Research Fellowship, Karonliska Institutet, Stockholm |
Experience & Service
Academic Appointments
Visiting Associate Professor, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2019
Principal investigator, Department of Department of Oncology-Pathology, Karolinska Institutet, Stockholm, 2010 - 2016
Assistant Professor, Department of Department of Oncology-Pathology, Karolinska Institutet, Stockholm, 2009 - Present
Selected Publications
Peer-Reviewed Articles
- Pan T, Lin SC, Lee YC, Yu G, Song JH, Pan J, Titus M, Satcher RL, Panaretakis T, Logothetis C, Yu-Lee LY, Lin SH. Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone. Oncogene 40(27):4592-4603, 2021. e-Pub 2021. PMID: 34127814.
- Vardaki I, Corn P, Gentile E, Song JH, Madan N, Hoang A, Parikh N, Guerra L, Lee YC, Lin SC, Yu G, Santos E, Melancon MP, Troncoso P, Navone N, Gallick GE, Efstathiou E, Subudhi SK, Lin SH, Logothetis CJ, Panaretakis T. Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment. Clin Cancer Res 27(11):3253-3264, 2021. e-Pub 2021. PMID: 33753455.
- Yu G, Shen P, Lee YC, Pan J, Song JH, Pan T, Lin SC, Liang X, Wang G, Panaretakis T, Logothetis CJ, Gallick GE, Yu-Lee LY, Lin SH. Multiple pathways coordinating reprogramming of endothelial cells into osteoblasts by BMP4. iScience 24(4):102388, 2021. e-Pub 2021. PMID: 33981975.
- Corn PG, Zhang M, Nogueras-Gonzalez GM, Xiao L, Zurita AJ, Subudhi SK, Tu SM, Aparicio AM, Coarfa C, Rajapakshe K, Huang S, Navone NM, Lin SH, Wang G, Ramachandran S, Titus MA, Panaretakis T, Gallick GE, Efstathiou E, Troncoso P, Logothetis C. A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer. Clin Cancer Res 26(5):990-999, 2020. e-Pub 2020. PMID: 31941830.
- Koinis F, Corn P, Parikh N, Song J, Vardaki I, Mourkioti I, Lin SH, Logothetis C, Panaretakis T, Gallick G. Resistance to MET/VEGFR2 Inhibition by Cabozantinib Is Mediated by YAP/TBX5-Dependent Induction of FGFR1 in Castration-Resistant Prostate Cancer. Cancers (Basel) 12(1), 2020. e-Pub 2020. PMID: 31963871.
- Vardaki I, Sanchez C, Fonseca P, Olsson M, Chioureas D, Rassidakis G, Ullén A, Zhivotovsky B, Björkholm M, Panaretakis T. Caspase-3-dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells. Blood 128(23):2655-2665, 2016. e-Pub 2016. PMID: 27742710.
- Vardaki I, Ceder S, Rutishauser D, Baltatzis G, Foukakis T, Panaretakis T. Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes. Oncotarget 7(46):74966-74978, 2016. PMID: 27589561.
- Ronquist KG, Sanchez C, Dubois L, Chioureas D, Fonseca P, Larsson A, Ullén A, Yachnin J, Ronquist G, Panaretakis T. Energy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells. J Extracell Vesicles 5:29877, 2016. e-Pub 2016. PMID: 26955882.
- Kharaziha P, Ceder S, Li Q, Panaretakis T. Tumor cell-derived exosomes: a message in a bottle. Biochim Biophys Acta 1826(1):103-11, 2012. e-Pub 2012. PMID: 22503823.
Book Chapters
- Fonseca P, Vardaki I, Occhionero A, Panaretakis T. Chapter Five: Metabolic and Signaling Functions of Cancer Cell-Derived Extracellular Vesicles. In: International Review of Cell and Molecular Biology. Elsevier, 175-199, 2016.
Grant & Contract Support
| Title: | Prostate Cancer Moon Shot Flagship 2:Development of Rational Immunotherapy Combinations to Overcome the Immunosuppressive Prostate Tumor Microenvironment |
| Funding Source: | MD Anderson Moon Shot Program |
| Role: | Co-Leader |
| Title: | Exosome Profiling of Immune and Non-Immune Bone Microenvironment to Improve Therapeutic Effect for Metastatic Prostate Cancer |
| Funding Source: | Cancerfonden (Swedish Cancer Society) |
| Role: | Principal Investigator |
| Title: | Impact of Local Therapy on Outcomes of Men with de novo Metastatic within Molecularly Defined Prostate Cancers |
| Funding Source: | Prostate Cancer Foundation |
| Role: | Co-Principal Investigator |
| Title: | Prostate Cancer Moonshot Flagship 1: Development of Mechanism-based Combination Therapies for Castration-Resistant Prostate Cancer Subproject: Targeting Prostate Cancer-Induced Aberrant Bone Formation for the Treatment of Bone Metastasis (S-H Lin) |
| Funding Source: | MD Anderson Moon Shot Program |
| Role: | Co-Leader |
| Title: | Project 3: Development of Rational Immunotherapy Combinations to Overcome the Immunosuppressive Prostate Tumor Microenvironment |
| Funding Source: | MD Anderson Moon Shot Program |
| Role: | Collaborator |