Thomas H. Beckham, M.D., Ph.D.

Peer-Reviewed Articles

1. Beckham TH, Rooney MK, McAleer MF, Ghia AJ, Tom MC, Perni S, McGovern S, Grosshans D, Chung C, Wang C, De B, Swanson T, Paulino A, Jiang W, Ferguson S, Patel CB, Li J, Yeboa DN. Hypofractionated radiotherapy for glioblastoma: A large institutional retrospective assessment of 2 approaches. Neurooncol Pract 11(3):266-274, 2024. e-Pub 2024. PMID: 38737610.
2. Beckham TH, Rooney MK, Cifter G, Bernard V, McAleer MF, De BS, Tom MC, Perni S, Wang C, Swanson T, Tatsui CE, Alvarez-Breckenridge C, North R, Rhines LD, Tang C, Logothetis C, Amini B, Li J, Yeboa DN, Ghia AJ. Stereotactic radiosurgery for prostate cancer spine metastases: local control and fracture risk using a simultaneous integrated boost approach. J Neurosurg Spine 14:1-9. e-Pub 2024. PMID: 38875722.
3. Wang C, Rooney MK, Alvarez-Breckenridge C, Beckham TH, Chung C, De BS, Ghia AJ, Grosshans D, Majd NK, McAleer MF, McGovern SL, North RY, Paulino AC, Perni S, Reddy JP, Rhines LD, Swanson TA, Tatsui CE, Tom MC, Yeboa DN, Li J. Outcomes and Pattern of Care for Spinal Myxopapillary Ependymoma in the Modern Era-A Population-Based Observational Study. Cancers (Basel) 16(11), 2024. e-Pub 2024. PMID: 38893133.
4. Shanker MD, Cavazos AP, Li J, Beckham TH, Yeboa DN, Wang C, McAleer MF, Briere TM, Amini B, Tatsui CE, North RY, Alvarez-Breckenridge CA, Cezayirli PC, Rhines LD, Ghia AJ, Bishop AJ. Definitive single fraction spine stereotactic radiosurgery for metastatic sarcoma: Simultaneous integrated boost is associated with high tumor control and low vertebral fracture risk. Radiother Oncol 193:110119, 2024. e-Pub 2024. PMID: 38311030.
5. Yadav D, Upadhyay R, Kumar VA, Chen MM, Johnson JM, Langshaw H, Curl BJ, Farhat M, Talpur W, Beckham TH, Yeboa DN, Swanson TA, Ghia AJ, Li J, Chung C. Additive Value of MR Simulation Prior to Chemoradiation in Evaluating Treatment Response and Pseudoprogression in High-Grade Gliomas. Pract Radiat Oncol. e-Pub 2024. PMID: 38685448.
6. Gallitto M, Sedor G, Lee A, Pasetsky J, Kinslow CJ, Santos GL, Obiri-Yeboah D, Kshettry VR, Helis CA, Chan MD, Beckham TH, McGovern SL, Matsui J, Palmer JD, Bell JB, Mellon EA, Lakomy D, Huang J, Boor I, Rusthoven CG, Sisti MB, Wang TJC. Salvage Stereotactic Radiosurgery for Recurrent WHO Grade 2 and 3 Meningiomas: A Multicenter Study (STORM). Int J Radiat Oncol Biol Phys. e-Pub 2024. PMID: 38641234.
7. Ledbetter D, de Almeida R, Wu X, Naveh A, Patel CB, Gonzalez Q, Beckham TH, North R, Rhines L, Li J, Ghia A, Aten D, Tatsui C, Alvarez-Breckenridge C. Tumor treating fields suppress tumor cell growth and neurologic decline in models of spine metastases. JCI Insight. e-Pub 2024. PMID: 38512420.
8. de Almeida RAA, Ghia AJ, Amini B, Wang C, Alvarez-Breckenridge CA, Li J, Rhines LD, Tom MC, North RY, Beckham TH, Tatsui CE. Quantification of MRI Artifacts in Carbon Fiber Reinforced Polyetheretherketone Thoracolumbar Pedicle Screw Constructs prior to Spinal Stereotactic Radiosurgery. Pract Radiat Oncol 14(2):103-111, 2024. e-Pub 2023. PMID: 37914081.
9. Sherry AD, Maroongroge S, De B, Amini B, Conley AP, Bishop AJ, Wang C, Beckham T, Tom M, Briere T, Li J, Yeboa DN, McAleer MF, North R, Tatsui CE, Rhines LD, Ghia AJ. Management of chordoma and chondrosarcoma with definitive dose-escalated single-fraction spine stereotactic radiosurgery. J Neurooncol 164(2):377-386, 2023. e-Pub 2023. PMID: 37667065.
10. Dodoo GN, De B, Lee SS, Abi Jaoude J, Vauthey JN, Tzeng CD, Tran Cao HS, Katlowitz KA, Mandel JJ, Beckham TH, Minsky BD, Smith GL, Holliday EB, Koong AC, Das P, Taniguchi CM, Javle M, Koay EJ, Ludmir EB. Brain Metastases from Biliary Tract Cancer: Case Series and Clinicogenomic Analysis. Oncologist 28(4):327-332, 2023. e-Pub 2023. PMID: 36715178.
11. Florez MA, De B, Cavazos A, Farooqi A, Beckham TH, Wang C, Yeboa DN, Bishop AJ, McAleer MF, Briere T, Amini B, Li J, Tatsui CE, Rhines LD, Ghia AJ. Safety and Efficacy of Dose-Escalated Radiation Therapy With a Simultaneous Integrated Boost for the Treatment of Spinal Metastases. Pract Radiat Oncol 13(1):e7-e13, 2023. e-Pub 2022. PMID: 36604100.
12. Hasanov E, Yeboa DN, Tucker MD, Swanson TA, Beckham TH, Rini B, Ene CI, Hasanov M, Derks S, Smits M, Dudani S, Heng DYC, Brastianos PK, Bex A, Hanalioglu S, Weinberg JS, Hirsch L, Carlo MI, Aizer A, Brown PD, Bilen MA, Chang EL, Jaboin J, Brugarolas J, Choueiri TK, Atkins MB, McGregor BA, Halasz LM, Patel TR, Soltys SG, McDermott DF, Elder JB, Baskaya MK, Yu JB, Timmerman R, Kim MM, Mut M, Markert J, Beal K, Tannir NM, Samandouras G, Lang FF, Giles R, Jonasch E. An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma. CA Cancer J Clin 72(5):454-489, 2022. e-Pub 2022. PMID: 35708940.
13. Beckham TH, Yang TJ, Gomez D, Tsai CJ. Metastasis-directed therapy for oligometastasis and beyond. Br J Cancer 124(1):136-141, 2021. e-Pub 2020. PMID: 33204024.
14. Beckham TH, Yang JC, Chau KW, Noy A, Yahalom J. Excellent Outcomes with Surgery or Radiotherapy in the Management of Castleman Disease Including a Case of Oligocentric Disease. Clin Lymphoma Myeloma Leuk 20(10):685-689, 2020. e-Pub 2020. PMID: 32522439.
15. Beckham TH, Barney C, Healy E, Wolfe AR, Branstetter A, Yaney A, Riaz N, McBride SM, Tsai CJ, Kang J, Yu Y, Chen L, Sherman E, Dunn L, Pfister DG, Tan J, Rupert R, Bonomi M, Zhang Z, Lobaugh SM, Grecula JC, Mitchell DL, Wobb JL, Miller ED, Blakaj DM, Diavolitsis VM, Lee N, Bhatt AD. Platinum-based regimens versus cetuximab in definitive chemoradiation for human papillomavirus-unrelated head and neck cancer. Int J Cancer 147(1):107-115, 2020. e-Pub 2019. PMID: 31609479.
16. Groen AH, Beckham TH, Links TP, Goldman DA, Sherman EJ, Tuttle MM, Bijl HP, Wong RJ, Plukker JTM, Lee NY, and other Group/Consortium Members. Outcomes of surgery and postoperative radiation therapy in managing medullary thyroid carcinoma. J Surg Oncol. e-Pub 2019. PMID: 31733124.
17. Beckham TH, Leeman JE, Xie P, Li X, Goldman DA, Zhang Z, Sherman E, McBride S, Riaz N, Lee N, Tsai CJ. Long-term survival in patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed therapy. Br J Cancer 121(11):897-903, 2019. e-Pub 2019. PMID: 31649318.
18. Zhang J, Srivastava S, Wang C,Beckham TH, Johnson C, Dutta P, Shepherd A, Mechalakos J, Hunt M, Wu A, Rimner A, Li G. Clinical evaluation of 4D MRI in the delineation of gross and internal tumor volumes in comparison with 4DCT. J Appl Clin Med Phys 20(9):51-60, 2019. PMID: 31538719.
19. Beckham TH, Imber BS, Simone CB. Stereotactic body radiation therapy for oligometastatic renal cell carcinoma: improving outcomes in an otherwise radioresistant malignancy. Ann Transl Med 7(Suppl 3):S98, 2019. PMID: 31576305.
20. Beckham TH, Leeman J, Jillian Tsai C, Riaz N, Sherman E, Singh B, Lee N, McBride S, Higginson DS. Treatment modalities and outcomes of Fanconi anemia patients with head and neck squamous cell carcinoma: Series of 9 cases and review of the literature. Head Neck 41(5):1418-1426, 2019. e-Pub 2019. PMID: 30633423.
21. Beckham TH, Romesser PB, Groen AH, Sabol C, Shaha AR, Sabra M, Brinkman T, Spielsinger D, McBride S, Tsai CJ, Riaz N, Tuttle RM, Fagin JA, Sherman EJ, Wong RJ, Lee NY. Intensity-Modulated Radiation Therapy With or Without Concurrent Chemotherapy in Nonanaplastic Thyroid Cancer with Unresectable or Gross Residual Disease. Thyroid 28(9):1180-1189, 2018. PMID: 30105947.
22. Orwat KP, Beckham TH, Cooper SL, Ashenafi MS, Anderson MB, Guimaraes M, Yamada R, Marshall DT. Pretreatment albumin may aid in patient selection for intrahepatic Y-90 microsphere transarterial radioembolization (TARE) for malignancies of the liver. J Gastrointest Oncol 8(6):1072-1078, 2017. PMID: 29299369.
23. Beckham TH, Casey DL, LaQuaglia MP, Kushner BH, Modak S, Wolden SL. Renal Function Outcomes of High-risk Neuroblastoma Patients Undergoing Radiation Therapy. Int J Radiat Oncol Biol Phys 99(2):486-493, 2017. e-Pub 2017. PMID: 28872000.
24. Price ST, Beckham TH, Cheng JC, Lu P, Liu X, Norris JS. Sphingosine 1-Phosphate Receptor 2 Regulates the Migration, Proliferation, and Differentiation of Mesenchymal Stem Cells. Int J Stem Cell Res Ther 2(2), 2015. e-Pub 2015. PMID: 27275017.
25. Cheng JC, Bai A,Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR, Bielawska A, Norris JS, Liu X. Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse. J Clin Invest 123(10):4344-58, 2013. e-Pub 2013. PMID: 24091326.
26. Beckham TH, Cheng JC, Lu P, Shao Y, Troyer D, Lance R, Marrison ST, Norris JS, Liu X. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis 2:e49, 2013. e-Pub 2013. PMID: 23732709.
27. Beckham TH, Cheng JC, Marrison ST, Norris JS, Liu X. Interdiction of sphingolipid metabolism to improve standard cancer therapies. Adv Cancer Res 117:1-36, 2013. PMID: 23290775.
28. Beckham TH, Cheng JC, Lu P, Marrison ST, Norris JS, Liu X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One 8(10):e76593, 2013. e-Pub 2013. PMID: 24098536.
29. Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X. LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria. J Pharmacol Exp Ther 344(1):167-78, 2013. e-Pub 2012. PMID: 23086228.
30. Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer 131(9):2034-43, 2012. e-Pub 2012. PMID: 22322590.
31. Turner LS, Cheng JC, Beckham TH, Keane TE, Norris JS, Liu X. Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide. Prostate Cancer Prostatic Dis 14(1):30-7, 2011. e-Pub 2010. PMID: 21116286.
32. Beckham TH, Elojeimy S, Cheng JC, Turner LS, Hoffman SR, Norris JS, Liu X. Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials. Expert Opin Ther Targets 14(5):529-39, 2010. PMID: 20334489.
33. Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, Keane TE, Hannun YA, Norris JS. Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opin Ther Targets 13(12):1449-58, 2009. PMID: 19874262.
34. Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther 17(3):430-8, 2009. e-Pub 2008. PMID: 19107118.
35. Wang X, Beckham TH, Morris JC, Chen F, Gangemi JD. Bioactivities of gossypol, 6-methoxygossypol, and 6,6'-dimethoxygossypol. J Agric Food Chem 56(12):4393-8, 2008. e-Pub 2008. PMID: 18517219.
36. Kalman A. Katlowitz, MD, PhD, Thomas H. Beckham, MD, PhD, Rajat J. Kudchadker, PhD, Jeffrey Wefel, PhD,Yasir Y. Elamin, MD, and Jeffrey S. Weinberg, MD. A Novel Multimodal Approach to Refractory Brain Metastases: A Case Report. Advances in Radiation Oncology.