About Dr. Xie
Head and neck cancer is one of the most common cancers in the world. Our research projects are to investigate the molecular mechanism of development and progression of head and neck cancer, including deregulation of tumor suppressor genes and oncogenes. Also, our research involves the understanding of metabolic alterations in head and neck cancer, which are regulated with alterations of tumor suppressor genes and oncogenes. Our goal is to develop novel therapeutic strategies.
Instructor, Department of Head and Neck Surgery - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
1. Signal tranduction regulation of oncogenes and tumor suppressor genes
3. Gene therapy
|2000||Oita Medical University, Oita, JPN, PHD, Philosophy|
|1987||Hebei Medical University, Shijiazhuang, CHN, MS, Medicine/Pathology|
|1983||Hebei Medical University, Shijiazhuang, CHN, MD, Medicine|
|2005-2006||Postdoctoral Fellow, Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX|
|2002-2005||Postdoctoral Fellow, Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX|
|2000-2002||Postdoctoral Fellow, Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX|
|1983-1984||Resident, Orthopedics, Baoding Hospital, Baoding, China|
|1981-1983||Intern, Hebei Medical University Affiliated Hospitals, Shijiazhuang|
|1998||The First Prize of Scientific and Technological Advance, The Scientific and Technological Committee of Hebei Province, China|
|1997||The Third Prize of Scientific and Technological Advance, The Scientific and Technological Committee of Hebei Province, China|
- Xie TX, Aldape KD, Gong W, Kanzawa T, Suki D, Kondo S, Lang F, Ali-Osman F, Sawaya R, Huang S. Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int J Oncol 33(1):5-15, 2008. PMID: 18575745.
- Zhou G, Xie TX, Zhao M, Jasser SA, Younes MN, Sano D, Lin J, Kupferman ME, Santillan AA, Patel V, Gutkind JS, Ei-Naggar AK, Emberley ED, Watson PH, Matsuzawa SI, Reed JC, Myers JN. Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity. Oncogene 27(25):3527-38, 2008. PMID: 18223693.
- Xie TX, Huang F, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S.. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Research 66(6):3188-96, 2006.
- Liu, MG, Dai BB, Kang SH, Ban KC, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, and Huang S.. FoxM1 is Overexpressed in Human Glioblastomas and Critically Regulates Tumorigenecity of Glioma Cells. Cancer Research 66(7):3593-3602, 2006.
- Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23:3550-3560, 2004.