Uddalak Bharadwaj, Ph.D.
Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Infectious Diseases, Infection Control and Employee Health, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Instructor, Department of Medicine, Baylor College of Medicine, Houston, TX
Research Associate, Baylor College of Medicine, Houston, TX
Post-Doctoral/ Research Associate, Baylor College of Medicine, Houston, TX
Post-Doctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2004 | Genetics, SGPGI, India, India, IN, Ph.D. in Immunogenetics |
| 1996 | Calcutta University, Kolkata, IN, M.S. in Biochemistry |
| 1994 | Calcutta University, Kolkata, IN, BS in Chem (Hons) |
Postgraduate Training
| 2010-2011 | Research Associate, Drug Development, Cancer Biology, Baylor College of Medicine, Houston, Texas |
| 2003-2010 | Post-Doctoral/Research Associate, Cancer Biology, Cancer Immunotherapy, Baylor College of Medicine, Houston, Texas |
| 2002-2003 | Post-Doctoral Research, Cancer Biology, MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Academic Appointments
Instructor, Department of Medicine, Baylor College of Medicine, Houston, TX, 2011 - 2015
Research Associate, Baylor College of Medicine, Houston, TX, 2010 - 2011
Post-Doctoral/ Research Associate, Baylor College of Medicine, Houston, TX, 2003 - 2010
Post-Doctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, 2002 - 2003
Honors & Awards
| 2008 | 3rd Best Presentation (Post-Doc), Baylor College of Medicine |
| 2008 | Christine Noonan Award for Outstanding Research, Baylor College of Medicine |
| 2004 - 2007 | Molecular Surgeon Young Investigator Award, Baylor College of Medicine |
| 2002 | Merit Award, 13th International Histocompatibility Workshop and Congress |
Selected Publications
Peer-Reviewed Articles
- García, JP, Wurster, ST, Albert, ND, Bharadwaj, U, Bhoda, K, Kulkarni, VK, Ntita, M, Carstens, PR, Burch-Eapen, M, López, DC, Lizaola, JF, Larsen, KE, Matula, LM, Moghaddam, SM, Wang, Y, Kontoyiannis, DP, Evans, S. Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis. mBio 16(5), 2025. e-Pub 2025. PMID: 40197039.
- Kumar, PR, Wurster, ST, Bavisi, K, da Silva, TA, Hauser, P, Kinnitt, J, Albert, ND, Bharadwaj, U, Neelapu, SS, Kontoyiannis, DP. A novel lentiviral vector-based approach to generate chimeric antigen receptor T cells targeting Aspergillus fumigatus. mBio 15(4), 2024. e-Pub 2024. PMID: 38415653.
- Wurster, ST, Albert, ND, Bharadwaj, U, Kasembeli, MM, Tarrand, JJ, Daver, N, Kontoyiannis, DP. Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis. Frontiers in immunology 13, 2022. e-Pub 2022. PMID: 35251033.
Abstracts
- Yuan H, Houck K, Tian Y, Zhou Z, Bharadwaj U, Wu X, Tweardy DJ, Romo D, Fu X, Zhang J, Dong JF. Piperlongumine Blocks JAK2-STAT3 Pathway to Inhibit Collagen-induced Platelet Reactivity Independent of Reactive Oxygen Species. Blood 124(21), 2014. e-Pub 2014.
- Lewis K, Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Cho SN, Liu J, DeMayo FJ, Tweardy DJ. Signaling Transducer and Activator of Transcription (Stat)3 Signaling and Targeting for Treatment and Prevention of Non-small Cell Lung Cancer. Chest, 2014. e-Pub 2014.
- Marin-Muller C, Bharadwaj U, Li M, Chen C, Yao Q. The role of MIR-198 in the regulatory circuitry of mesothelin-overexpressing pancreatic cancer pathogenesis, 2009. e-Pub 2009.
- Bharadwaj U, Marin-muller C, Li M, Chen C, Yao Q. Novel MSLN-Aph 1A interaction induced Notch Activation in pancreatic cancer pathogenesis, 2009. e-Pub 2009.
- Lay MK, Bharadwaj U, Hong H, Neil FH, K Sastry QYJ, Atmar RL, Estes MK. Norwalk Virus do not replicate in human macrophages or dendritic cells from the peripheral blood of susceptible humans, 2009. e-Pub 2009.
- Lackey K, Zhang S, Marin-Muller C, Bharadwaj U, Li M, Chen C, Yao Q. Modulating immunosuppressive cytokine production in mesothelin-overexpressing pancreatic cancer cells by micro-RNA, 2009. e-Pub 2009.
- Marin-Muller C, Bharadwaj U, Li M, Chen C, Yao Q. The role of MIR-198 in the regulatory circuitry of mesothelin-overexpressing pancreatic cancer pathogenesis, 2009. e-Pub 2009.
- Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Novel MSLN-Aph1A interaction induced Notch Activation in pancreatic cancer pathogenesis, 2009. e-Pub 2009.
- Lackey K, Zhang S, Marin-Muller C, Bharadwaj U, Li M, Chen C, Yao Q. Modulating immunosuppressive cytokine production in mesothelin-overexpressing pancreatic cancer cells by micro-RNA, 2009. e-Pub 2009.
- Li M, Zhang Y, Bharadwaj U, Zhai Q, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Sielncing of Zinc transporter Zip4 inhibits Pancreatic cancer Growth and Increases the survival of nude mice with pancreatic cancer xenografts, 2008. e-Pub 2008.
- Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin Overexpression Promotes IL-6 production and autocrine signaling in enhancing Pancreatic Cancer cell Proliferation, 2008. e-Pub 2008.
- Marin-Muller C, Bharadwaj U, Li M, Chen C, Yao Q. Meothelin-Overexpressing Pancreatic Cancer cell down-Regulate Mir-198 to facilitate cell Proliferation, Invasion and Migration, 2008. e-Pub 2008.
- Wang H, Li M, Bharadwaj U, Mu H, Zhang S, Yao Q, Chen C. Non-coding XIST RNA is decreased in pancreatic cancer and retroviral gene delivery of XIST RNS gene inhibits opancreatic cancer growth in vitro and in Vivo, 2008. e-Pub 2008.
- Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin Activiites AKt Signaling Pathway Which Leads To Cell NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells, 2008. e-Pub 2008.
- Bharadwaj U, marin-Muller C, li M, Chen C, Yao Q. Mesothelin Overexpression Promotes IL-6 production and autocrine signaling in enhancing Pancreatic Cancer cell Proliferation, 2008. e-Pub 2008.
- Marin-Muller C, Bharadwaj U, Li M, Chen C, Yao Q. Meothelin-Overexpressing Pancreatic Cancer cells down-Regulate Mir-198 to facilitate cell Proliferation, Invasion and Migration, 2008. e-Pub 2008.
- Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin Activates Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells, 2007. e-Pub 2007.
- Lay MK, Bharadwaj U, Hong H, Neil FH, K Sastry QYJ, Atmar RL, Estes MK. Norwalk Virus do not replicate in human macrophages or dendritic cells from the peripheral blood of susceptible humans, 2007. e-Pub 2007.
- Lay MK, Guix S, Bharadwaj U, Yao Q, Atmar RL, Estes MK. Does Norwalk Virus replicate in human dendritic cells?, 2007. e-Pub 2007.
- Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin Activities Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells, 2007. e-Pub 2007.
- Agarwal N, Liebig C, Tuszynski GP, Bharadwaj U, Albo D. Fibroblasts Upregulate Gelatinase Activity and Promote Tumor Cell Invasion in Colon Cancer through Angiocidin, 2007. e-Pub 2007.
- Bharadwaj U, Agarwal N, Li M, Chen C, Yao Q. Overexpression of Mesothelin in pancreatic cancer is associated with enhanced cell adhesion, migration and invasion, 2007. e-Pub 2007.
- Bharadwaj U, Li M, Chen C, Yao Q. Overexpression of Meso thelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation Of The Transcription Factor Stat3, 2007. e-Pub 2007.
- li M, Bharadwaj U, Zhang R, Zhang S, Mu H, Fisher WAE, Brunicardi FC, Chen C, Yao Q. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer, 2007. e-Pub 2007.
- Agarwal N, Liebig C, Tuszynski GP, Bharadwaj U, Gupta N, Albo D. Role of Angiocidin in Gelatinase Expression and Tumor Cell Invasion in Colon Cancer, 2007. e-Pub 2007.
- Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin induces inflammatory cytokine production and enhances pancreatic cancer migration and proliferation by activating the transcription factor STAT3, 2006. e-Pub 2006.
- Agarwal N, Liebig C, Tuszynski GP, Bharadwaj U, Albo D. Role of angiocidin in gelatinase expression and tumor cell invasion in colon cancer, 2006. e-Pub 2006.
- Li M, Feurino L, Bharadwaj U, Zhang R, Li F, Chai H, Fisher WE, Brunicardi FC, Chen C, Yao Q. IL-6 promotes pancreatic cancer Growth by upregulating VEGF and neuropilins, and increasing TH2 cytokine secretion, 2006. e-Pub 2006.
- Agarwal N, Liebig C, Tuszynski GP, Bharadwaj U, Gupta N, Albo D. Role of Angiocidin in Gelatinase Expression and Tumor Cell Invasion in Colon Cancer, 2006. e-Pub 2006.
- Bharadwaj U, Li M, Chen C, Yao Q. Overexpression Of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation Of The Transcription Factor Stat3, 2006. e-Pub 2006.
- Bharadwaj U, Li M, Chen C, Yao Q. Overexpression of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation Of TheTranscription Factor Stat3, 2006. e-Pub 2006.
- Agrawal N, Liebig C, Tuszynski GP, Bharadwaj U, Albo D. Angiocidin, A Novel Thrombospondin-1 Receptor, and Matrix Gelatinases are Up-regulated in Colorectal Cancer, 2005. e-Pub 2005.
- Li M, Zhai Q, Bharadwaj U, Wang H, Yang H, Chai H, Li F, Fisher WE, Chen C, Yao Q. Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147, 2005. e-Pub 2005.
- Bharadwaj U, Li M, Zhang R, Lin XD, Chen C, Yao Q. Inhibition Of Dendritic Cell Differentiation And Activation By Pancratic Cancer Cell Line BxPC3, 2005. e-Pub 2005.
- Bharadwaj U, Li M, Zhang R, Yang H, Doan LX, Chen C, Yao Q. Cyclophilin A Modulates Dendritic Cell Differentiation From Myeloblastic Cell KG-1, 2004. e-Pub 2004.
- Bharadwaj U, Li M, Zhang R, Lin XD, Chen C, Yao Q. Suppression of dendritic cell differentiation and activation by human pancreatic cancer cell line BxPC-3, 2004. e-Pub 2004.
- Bharadwaj U, Li M, Zhang R, Lin XD, Chen C, Yao Q. Inhibition Of Dendritic Cell Differentiation And Activation By Pancreatic Cancer Cell Line BxPC3: The Role Of Interleukin-6 And Granulocyte Colony-Stimulating Factor, 2004. e-Pub 2004.
- Bharadwaj U, Mishra RN, Aggarwal A, Naik S, Agrawal S. HV3 shared epitope and molecular mimicry in rheumatoid arthritis: a study from north India, 2002. e-Pub 2002.
- Bharadwaj U, Mishra RN, Aggarwal A, Naik S, Agrawal S. HLA class II genes and rheumatoid arthritis: a study from Uttar Pradesh, 2001. e-Pub 2001.
- Sharma A, Bharadwaj U, Bhatnagar S, Khan F, Agarwal SS, Agrawal S. DNA short tandem repeat profiling of three north Indian populations, 2000. e-Pub 2000.
- Bharadwaj U, Bhatnagar S, Sharma A, Talwar S, Khan F, Agarwal SS, Agrawal S. HLA class II antigen distribution in Three North Indian population from Uttar Pradesh, 2000. e-Pub 2000.
- Khan F, Bharadwaj U, Sharma A, Bhatnagar S, Agarwal SS, Agrawal S. Analysis of Apolipoprotiein B Gene 3 Hypervariable Region among three North Indian population and comparison with other world population, 2000. e-Pub 2000.
- Bharadwaj U, Agrawal S, Bhatnagar S, Myhsok BM, Agarwal SS. Allele frequencies for 24 microsatellites in three endogamous populations of North India (U.P.), 2000. e-Pub 2000.
- Bharadwaj U, Mishra RN, Aggarwal A, Naik S, Agrawal S. HLA DR/DQ interaction in Rheumatoid Arthritis, 2000. e-Pub 2000.
Selected Presentations & Talks
National Presentations
- 2015. Targeting STAT3 with an oral small molecule inhibitor to reverse chemotherapy and radiation resistance. Conference. Targeting STAT3 with an oral small molecule inhibitor to reverse chemotherapy and radiation resistance, US.
- 2014. Piperlongumine Blocks JAK2-STAT3 Pathway to inhibit Collagen -Induced Platelet Reactivity Independent of Reactive Oxygen Species. Conference. Piperlongumine Blocks JAK2-STAT3 Pathway to inhibit Collagen -Induced Platelet Reactivity Independent of Reactive Oxygen Species, US.
- 2009. Novel MSLN-Aph1A interaction induced Notch Activation in pancreatic cancer pathogenesis. Conference. Novel MSLN-Aph1A interaction induced Notch Activation in pancreatic cancer pathogenesis, US.
- 2009. Novel MSLN-Aph1A interaction induced Notch Activation in pancreatic cancer pathogenesis. Conference. Novel MSLN-Aph1A interaction induced Notch Activation in pancreatic cancer pathogenesis, US.
- 2008. Mesothelin Overexpression Promotes IL-6 production and autocrine signaling in enhancing Pancreatic Cancer cell Proliferation. Conference. Mesothelin Overexpression Promotes IL-6 production and autocrine signaling in enhancing Pancreatic Cancer cell Proliferation. Houston, TX, US.
- 2008. Mesothelin Activates Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells. Conference. Mesothelin Activates Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells. Huntington Beach, CA, US.
- 2008. Mesothelin Overexpression Promotes IL-6 production and autocrine signaling in enhancing Pancreatic Cancer cell Proliferation. Conference. Mesothelin Overexpression Promotes IL-6 production and autocrine signaling in enhancing Pancreatic Cancer cell Proliferation. Houston, TX, US.
- 2007. Mesothelin Activates Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells. Conference. Mesothelin Activates Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells, US.
- 2007. Mesothelin Activates Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells. Conference. Mesothelin Activates Akt Signaling Pathway Which Leads To NF-B Activation And Resistance To TNF Induced Apoptosis In Pancreatic Cancer Cells. Houston, TX, US.
- 2007. Overexpression Of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation Of The Transcription Factor Stat3. Conference. Overexpression Of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation Of The Transcription Factor Stat3. Phoenix, AZ, US.
- 2006. Mesothelin induces inflammatory cytokine production and enhances pancreatic cancer migration and proliferation by activating the transcription factor Stat3. Conference. Mesothelin induces inflammatory cytokine production and enhances pancreatic cancer migration and proliferation by activating the transcription factor Stat3. Houston, TX, US.
- 2006. Overexpression Of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation of The Transcription Factor Stat3. Conference. Overexpression Of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation of The Transcription Factor Stat3, US.
- 2006. Overexpression Of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation Of The Transcription Factor Stat3. Conference. Overexpression Of Mesothelin In Pancreatic Cancer Cells Promotes Tumor Cell Growth Via Activation Of The Transcription Factor Stat3. Houston, TX, US.
- 2006. overexpression of Mesothelin in pancreatic cancer is associated with enhanced cell adhesion, migration and invasion. Conference. overexpression of Mesothelin in pancreatic cancer is associated with enhanced cell adhesion, migration and invasion. San Diego, CA, US.
- 2005. Inhibition Of Dendritic Cell Differentiation And Activation By Pancreatic Cancer Cell Line BxPC3. Conference. Inhibition Of Dendritic Cell Differentiation And Activation By Pancreatic Cancer Cell Line BxPC3. Nashville, TN, US.
- 2004. Cyclophilin A Modulates Dendritic Cell Differentiation From Myeloblastic Cell KG-1. Conference. Cyclophilin A Modulates Dendritic Cell Differentiation From Myeloblastic Cell KG-1. Houston, TX, US.
- 2004. Suppression of dendritic cell differentiation and activation by human pancreatic cancer cell line BxPC-3. Conference. Suppression of dendritic cell differentiation and activation by human pancreatic cancer cell line BxPC-3. Houston, TX, US.
- 2004. Inhibition Of Dendritic Cell Differentiation And Activation By Pancreatic Cancer Cell Line bxPC3: The Role Of Interleukin-6 And Granulocyte Colony-Stimulating Factor. Conference. Inhibition Of Dendritic Cell Differentiation And Activation By Pancreatic Cancer Cell Line bxPC3: The Role Of Interleukin-6 And Granulocyte Colony-Stimulating Factor. Houston, TX, US.
- 2002. HV3 shared epitope and molecular mimicry in rheumatoid arthritis: a study from north India. Conference. HV3 shared epitope and molecular mimicry in rheumatoid arthritis: a study from north India. Seattle, WA, US.
International Presentations
- 2001. HLA class II genes and rheumatoid arthritis: a study from Uttar Pradesh. Conference. HLA class II genes and rheumatoid arthritis: a study from Uttar Pradesh. New Delhi, IN.
- 2000. HLA class II antigen distribution in Three North Indian Population from Uttar Pradesh. Conference. HLA class II antigen distribution in Three North Indian Population from Uttar Pradesh. Hydrabad, IN.
- 2000. HLA DR/DQ interaction in Rheumatoid Arthritis. Conference. HLA DR/DQ interaction in Rheumatoid Arthritis. Nagpur, IN.
- 2000. Allele frequencies for 24 microsatellites in three endogamous populations of North India (U.P). Conference. Allele frequencies for 24 microsatellites in three endogamous populations of North India (U.P). Nagpur, IN.
Formal Peers
- 2008. Mesothelin activates Akt signaling pathway which leads to NF-B activation and resistance to apoptosis and anoikis in pancreatic cancer cells. Invited. Houston, TX, US.
- 2005. Suppression Of Dendritic Cell Differentiation And Activation By Human Pancreatic Cancer Cell Line BxPC-3. Invited. Houston, TX, US.
Grant & Contract Support
| Title: | GARP (BCM)-illumina-RNA-Seq-grant |
| Funding Source: | BCM |
| Role: | PI |
| ID: | GARP (BCM)-illumina-RNA-Seq-grant |
| Title: | C 188-9, a Stat1/3 inhibitor, to treat radioresistant H&N SCC xenografts |
| Funding Source: | AHNS |
| Role: | PI |
| ID: | Piolet Grant 313720 (41768-I) |
| Title: | Targeting Stat1 and Stat3 with a Dual-Acting Inhibitor to Reverse Radioresistance in Head and Neck Cancer |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | R21 191556 |
Patient Reviews
CV information above last modified June 20, 2025