William D Hopkins, BA, MS, PhD
Department of Comparative Medicine, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Director and Chair Ad Interim, Department of Comparative Medicine, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Bastrop, Texas
Professor, Department of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, Texas
Education & Training
Degree-Granting Education
| 1990 | Georgia State University, Atlanta, Georgia, US, Ph.D. in Psychology |
| 1986 | Georgia State University, Atlanta, Georgia, US, MA in Psychology |
| 1983 | University of Wisconsin, Madison, Wisconsin, US, BS in Psychology |
Experience & Service
Faculty Academic Appointments
Professor, Department of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, Texas, 2018 - 2020
President and Scientific Director, Ape Cognition and Conservation Initiative, Atlanta, Georgia, 2013 - 2018
Professor, Department of Neuroscience, Georgia State University, Atlanta, Georgia, 2012 - 2018
Professor, Department of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, Texas, 2011 - 2018
Professor, Department of Psychology, Agnes Scott College, Decatur, Georgia, 2006 - 2012
Assistant Professor, Department of Psychology, Emory University, Atlanta, Georgia, 1994 - 2002
Associate Professor, Department of Psychology, Berry College, Mount Berry, Georgia, 1994 - 2005
Instructor, Department of Psychology, Kennesaw State College, Kennesaw, Georgia, 1993 - 1994
Scientist, Department of Laboratory of Comparative Ethology, National Institutes of Child Health and Human Development, Bethesda, Maryland, 1992 - 1993
Associate Research Scientist, Centre Nationale de la Recherche Scientifique, Laboratoire de Neurosciences Fontionnelle, Unite de Neurosciences Cognitives, Marseille, 1991 - 1992
Research Scientist, Department of Psychology, Georgia State University, Atlanta, Georgia, 1990 - 2018
Instructor, Department of Psychology, Georgia State University, Atlanta, Georgia, 1989 - 1991
Associate Research Scientist, Department of Development and Cognitive Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, 1989 - 2018
Project Coordinator, Department of Psychology, Georgia State University, Atlanta, Georgia, 1986 - 1989
Graduate Research Assistant, Department of Psychology, Georgia State University, Atlanta, Georgia, 1983 - 1985
Undergraduate Research Assistant, Department of University of Wisconsin Primate Laboratory, University of Wisconsin, Madison, Wisconsin, 1980 - 1982
Administrative Appointments/Responsibilities
Director and Chair Ad Interim, Department of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, Texas, 2020 - Present
Editorial Activities
Associate Editor, American Journal of Primatology, 2018 - Present
Editorial Board Member, Laterality, 2018 - Present
Editorial Board Member, Primates, 2018 - Present
Editorial Board Member, International Journal of Primatology, 2018 - Present
Honors & Awards
| 2002 | Samuel and Poe Carden Award Recipient for Outstanding Scholarship, Teaching and Service, Berry College |
| 1987 | Merit Scholarship, Georgia State University |
| 1978 - 1980 | Academic/Athletic Scholarship, University of Wisconsin - Superior |
Professional Memberships
Selected Presentations & Talks
National Presentations
- Too many to list. Conference. Too many to list, US.
Formal Peers
- 2018. Blaise-Pascal Laureate. Invited, Paris, FR.
- 2015. Institute for Advanced Studies (IMERA). Invited, FR.
- Too many to list. Invited, US.
Grant & Contract Support
| Date: | 2023 - 2025 |
| Title: | The Effect of Aging on Neurotransmitters and Motor Performance in a Primate Model |
| Funding Source: | National Institutes of Aging |
| Role: | Co-PI |
| Date: | 2022 - 2024 |
| Title: | Collaborative Research: NCS: Foundations of learning: individual variation, plasticity, and evolution |
| Funding Source: | National Science Foundation (NSF) |
| Role: | PI |
| ID: | 2219751 |
| Date: | 2022 - 2027 |
| Title: | Innate Immunity Stimulation Effects on Biomarkers, Cognition, and the Vascular Amyloid Proteome in a Squirrel Monkey Model of Sporadic CAA |
| Funding Source: | NIH |
| Role: | Co-PI |
| ID: | 1R01NS128190-01 |
| Date: | 2021 - 2026 |
| Title: | A Squirrel Monkey Model of Alzheimer’s Disease: Developing Behavioral, Blood and CSF Biomarkers |
| Funding Source: | National Institutes of Aging |
| Role: | Principal Investigator-MDACC |
| Date: | 2021 - 2026 |
| Title: | Non-Human Primates Acquisition, Testing, Transportation and Housing |
| Funding Source: | NIH |
| Role: | PI |
| ID: | NIHODM920201121 |
| Date: | 2021 - 2024 |
| Title: | Genetic Determinants of Brain Size Development in a Primate Model of Autism-Spectrum Disorder |
| Funding Source: | National Institutes of Child Health and Human Development |
| Role: | Principal Investigator-MDACC |
| Date: | 2021 - 2026 |
| Title: | Alzheimer’s Disease Pathology in a Primate Model |
| Funding Source: | National Institutes of Aging |
| Role: | Principal Investigator-MDACC |
| Date: | 2020 - 2024 |
| Title: | NSF Rules of Life: Epigenetics |
| Funding Source: | National Science Foundation (NSF) |
| Role: | Principal Investigator-MDACC |
| Date: | 2020 - 2025 |
| Title: | Squirrel Monkey Breeding and Research Resource |
| Funding Source: | NIH Office of Research Infrastructure Programs |
| Role: | Principal Investigator-MDACC |
| Date: | 2017 - 2028 |
| Title: | Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR) |
| Funding Source: | NIH/OD |
| Role: | Co-PI |
| ID: | 2P40OD024628-06A1 |
Selected Publications
Peer-Reviewed Articles
- Neal Webb, SJ, Achorn, AM, Schapiro, SJ, Hopkins, WD, Simmons, JH. Neutrophil to lymphocyte ratio in captive olive baboons (Papio anubis). American journal of primatology 86(6), 2024. e-Pub 2024. PMID: 38482892.
- Foubet, O, Mangin, JF, Sun, ZY, Sherwood, CC, Hopkins, WD. Phylogenetic differences in the morphology and shape of the central sulcus in great apes and humans. Cerebral Cortex 34(6), 2024. e-Pub 2024. PMID: 38869374.
- Hopkins, WD, Cox, CM, Latzman, RD, Beran, MJ. Chimpanzees (Pan troglodytes) with better task-based delay of gratification skills are rated as less impulsive, more agreeable, and smarter. Journal of Comparative Psychology 138(3):203-210, 2024. e-Pub 2024. PMID: 38407079.
- Li X, Hopkins WD, Crow TJ, Roberts N. Comparison of surface area and cortical thickness asymmetry in the human and chimpanzee brain. Cerebral Cortex 34(2), 2024. e-Pub 2024. PMID: 33026423.
- Rickelton, K, Zintel, TM, Pizzollo, J, Miller, E, Ely, JJ, Raghanti, MA, Hopkins, WD, Hof, PR, Sherwood, CC, Bauernfeind, AL, Babbitt, CC. Tempo and mode of gene expression evolution in the brain across primates. eLife 13, 2024. e-Pub 2024. PMID: 38275218.
- Chauvel, M, Uszynski, I, Herlin, B, Popov, A, Leprince, Y, Mangin, JF, Hopkins, WD, Poupon, C. In vivo mapping of the deep and superficial white matter connectivity in the chimpanzee brain. NeuroImage 282, 2023. e-Pub 2023. PMID: 37722605.
- Achorn, AM, Mulholland, MM, Hopkins, WD. The effects of early rearing experiences on mutual eye gaze among captive olive baboons (Papio anubis). Developmental Psychobiology 65(7), 2023. e-Pub 2023. PMID: 37860908.
- Hopkins, WD, Mulholland, MM, Latzman, RD. Characterizing the personality and gray matter volume of chimpanzees that exhibit autism-related socio-communicative phenotypes. Personality Neuroscience 6, 2023. e-Pub 2023. PMID: 38107781.
- Jorstad, NL, Song, JH, Exposito-Alonso, D, Suresh, H, Castro-Pacheco, N, Krienen, FM, Yanny, AM, Close, J, Gelfand, E, Long, B, Seeman, SC, Travaglini, KJ, Basu, S, Beaudin, M, Bertagnolli, D, Crow, M, Ding, SL, Eggermont, J, Glandon, A, Goldy, J, Kiick, K, Kroes, T, McMillen, D, Pham, T, Rimorin, CF, Siletti, K, Somasundaram, S, Tieu, M, Torkelson, A, Feng, G, Hopkins, WD, Höllt, T, Keene, CD, Linnarsson, S, McCarroll, SA, Lelieveldt, BP, Sherwood, CC, Smith, K, Walsh, CA, Dobin, A, Gillis, J, Lein, E, Hodge, RD, Bakken, TE. Comparative transcriptomics reveals human-specific cortical features. Science 382(6667), 2023. e-Pub 2023. PMID: 37824638.
- Gallardo, G, Eichner, C, Sherwood, CC, Hopkins, WD, Anwander, A, Friederici, AD. Morphological evolution of language-relevant brain areas. PLoS biology 21(9 September), 2023. e-Pub 2023. PMID: 37656748.
- Hopkins WD, Staes N, Guevera EE, Mulholland MM, Sherwood CC & Bradley BJ. Vasopressin, and not oxytocin, receptor gene methylation is associated with individual differences in receptive joint attention in chimpanzees (Pan troglodytes). Autism Research 16(4):713-722, 2023. e-Pub 2023. PMID: 36738470.
- Hopkins WD, Coulon O, Meguerditchian A, Staes N, Sherwood CC, Schapiro SJ, Mangin JF, & Bradley B. Genetic determinants of individual variation in the superior temporal sulcus of chimpanzees (Pan troglodytes). Cerebral Cortex 33(5):1925-1940, 2023. e-Pub 2023. PMID: 35697647.
- Amiez C, Sallet J, Giacometti C, Verstraete C, Gandaux C, Morel-Latour V, Meguerditchian A, Hedj-Bouziane F, Hamed SB, Hopkins WD, Procyk E, Wilson CRE, Petrides M. A revised perspective on the evolution of the lateral frontal cortex in primates. Science Advances 9(20), 2023. e-Pub 2023. PMID: 37205762.
- Raghanti, MA, Miller, EN, Jones, DN, Smith, HN, Munger, EL, Edler, MK, Phillips, KA, Hopkins, WD, Hof, PR, Sherwood, CC, Lovejoy, CO. Hedonic eating, obesity, and addiction result from increased neuropeptide Y in the nucleus accumbens during human brain evolution. Proceedings of the National Academy of Sciences of the United States of America 120(38), 2023. e-Pub 2023. PMID: 37695892.
- Mulholland MM, Meguerditchian A, Hopkins WD. Age- and sex-related differences in baboon (Papio anubis) gray matter covariation. Neurobiology of Aging 125:41-48, 2023. e-Pub 2023. PMID: 36827943.
- Hopkins WD, Li X, Roberts N, Mulholland MM, Sherwood CC, Edler MK, Raghanti MA & Schapiro SJ. Age differences in cortical thickness and their association with cognition in chimpanzees (Pan troglodytes). Neurobiology of Aging 126:91-102, 2023. e-Pub 2023. PMID: 36958104.
- Edler MK, Munger EL, Maycon H, Hopkins WD, Hof PR, Sherwood CC, Taghanti MA. Examining the association of astrogliosis and microglial activation with aging and Alzheimer’s disease pathology in the chimpanzee brain. Journal of Neuroscience Methods 101(6):881-900, 2023. e-Pub 2023. PMID: 36647571.
- Van den Heuvel MP, Ardesch DJ, Scholtens LH, de Lange SC, van Haren NEM, Sommer I, Dannlowski U, Repple J, Preuss TM, Hopkins WD, Rilling JK. Human and chimpanzee shared and divergent neurobiological systems for general and specific cognitive brain functions. Proceedings of the National Academy of Sciences 120(22):e2218565120, 2023. e-Pub 2023. PMID: 37216540.
- Amiez C, Verstraete C, Sallet J, Petrides M, Sherwood CC, Hopkins WD. The relevance of the unique anatomy of the human prefrontal operculum to the emergence of speech. Communications Biology 6(1):693, 2023. e-Pub 2023. PMID: 37407769.
- Munger E, Edler M, Hopkins WD, Hof PR, Sherwood CC, Raghanti MA. Comparative analysis of astrocytes in the prefrontal cortex of primates: Insights into the evolution of human brain energetics. Journal of Comparative Neurology 530(18):3106-3125, 2022. e-Pub 2022. PMID: 35859531.
- Hopkins WD, Mulholland MM, Mareno MC, Webb SJN, & Schapiro SJ. Neuroanatomical correlates of individual differences in the object choice task in chimpanzees (Pan troglodytes). Frontiers in Comparative Psychology 13, 2022. e-Pub 2022. PMID: 36507015.
- Staes N, Guevara EE, Hopkins WD, Schapiro SJ, Eens M, Sherwood CC, & Bradley BJ. The role of serotonergic gene methylation in regulating anxiety-related personality traits in chimpanzees. Biology 11(11), 2022. e-Pub 2022. PMID: 36421387.
- Takeshita RSC, Edler MK, Meindl RS, Sherwood CC, Hopkins WD, & Raghanti MA. Age, adrenal steroids, and cognitive functioning in captive chimpanzees (Pan troglodytes). PeerJ 10, 2022. e-Pub 2022. PMID: 36389417.
- Hopkins, WD, Sprung-Much, T, Amiez, C, Procyk, E, Petrides, M, Schapiro, SJ, Sherwood, CC. A comprehensive analysis of variability in the sulci that define the inferior frontal gyrus in the chimpanzee (Pan troglodytes) brain. American Journal of Biological Anthropology 179(1):31-47, 2022. e-Pub 2022.
- Mulholland MM, Schapiro SJ, Sherwood CC, Hopkins WD. Phenotypic and genetic associations between gray matter covariation and tool use skill in chimpanzees (Pan troglodytes): Repeatability in two genetically isolated populations. Neuroimage 257, 2022. e-Pub 2022. PMID: 35551989.
- Lurz, R, Krachun, C, Hopkins, WD, Taglialatela, JP. Evidence of psychological essentialism in a symbol-trained bonobo (Pan paniscus). International Journal of Primatology 43(2):235-252, 2022. e-Pub 2022.
- Riviere D, Leprince Y, Labra N, Vindas N, Foubet O, Cagna B, Loh KK, Hopkins WD, Balzeau A, Mancip M, Lebenberg J, Cointepas Y, Coulon O, & Mangin JF. Browsing multiple subjects when the atlas adaptation cannot be achieved via a warping strategy. Frontiers in Neuroinformatics 16, 2022. e-Pub 2022. PMID: 35311005.
- Hopkins WD, Westerhausen R, Schapiro SJ, & Sherwood CC. Heritability in corpus callosum morphology and Its association with tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations. Genes, Brain and Behavior 21(2):e12784, 2022. e-Pub 2022. PMID: 35044083.
- Falcone C, McBride EL, Hopkins WD, Hof PR, Manger PR, Sherwood CC, Noctor SC, & Martínez-Cerdeño V. Redefining varicose projection astrocytes in primates. Glia 70(1):145-154, 2022. e-Pub 2022. PMID: 34533866.
- Guevara E, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, & Sherwood CC. Epigenetic aging of the prefrontal cortex and cerebellum in humans and chimpanzees. Epigenetics 17(12):1774-1785, 2022. e-Pub 2022. PMID: 35603816.
- Staes N, White CM, Guevara EE, Eens M, Hopkins WD, Schapiro SJ, Stevens JMG, Sherwood CC, & Bradley BJ. Chimpanzee extraversion scores vary with epigenetic modification of dopamine receptor gene D2 (DRD2) and early rearing conditions. Epigenetics 17(12):1701-1714, 2022. e-Pub 2022. PMID: 35345970.
- Lurz RW, Krachun C, Mareno MC, & Hopkins WD. Do chimpanzees predict others' behavior by simulating their beliefs?. Animal Behavior and Cognition 9(2):153-175, 2022. e-Pub 2022.
- Amiez C, Sallet J, Novek J, Hadj-Bouziane F, Giacometti C, Andersson J, Hopkins WD, Petrides M. Chimpanzee histology and functional brain imaging show that the paracingulate is not human specific. Communications Biology 4(1):54, 2021. e-Pub 2021. PMID: 33420330.
- Mulholland MM, Sherwood CC, Schapiro SJ, Raghanti MA, & Hopkins WD. Age- and cognition-related differences in gray matter volume of the chimpanzee brain (Pan troglodytes): A voxel-based morphometry and conjunction analysis. American Journal of Primatology 83(11), 2021. e-Pub 2021. PMID: 33899958.
- Weiss A, Wilson V, & Hopkins WD. Early social rearing, the V1A arginine vasopressin receptor genotype and autistic traits in chimpanzees. Autism Research 14(9):1843-1853, 2021. e-Pub 2021. PMID: 34089305.
- Miller EN, Hof PR, Sherwood CC, & Hopkins WD. The paracingulate sulcus is a unique feature of the medial frontal cortex shared in great apes and humans. Brain, Behavior and Evolution 96(1):26-36, 2021. e-Pub 2021. PMID: 34192698.
- Hirter, KN, Miller, EN, Stimpson, CD, Phillips, KA, Hopkins, WD, Hof, PR, Sherwood, CC, Lovejoy, CO, Raghanti, MA. The nucleus accumbens and ventral pallidum exhibit greater dopaminergic innervation in humans compared to other primates. Brain Structure and Function 226(6):1909-1923, 2021. e-Pub 2021. PMID: 34032910.
- Hopkins WD, Procyk E, Petrides M, Schapiro SJ, Mareno MC, Amiez C. Sulcal morphology in cingulate cortex is associated with oro-facial motor control and gestural communication in chimpanzees (Pan troglodytes). Cerebral Cortex 31(6):2845-2854, 2021. e-Pub 2021. PMID: 33447847.
- Guevera EE, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, & Sherwood CC. Comparative analysis reveals distinctive epigenetic features of the human cerebellum. PLoS Genetics 17(5):e1009506, 2021. e-Pub 2021. PMID: 33956822.
- Westerhausen R, Anders FM, Kompus K, Schapiro SJ, Sherwood CC, Walhovd KB, Hopkins WD. Comparative morphology of the corpus callosum across the adult lifespan in chimpanzees and humans. Journal of Comparative Neurology 529(7):1584-1596, 2021. e-Pub 2021. PMID: 32978976.
- Hopkins WD, Mareno MC, Webb Neal SJ, Schapiro SJ, Raghanti MA, & Sherwood CC. Age-related changes in chimpanzee (Pan troglodytes) cognition: Cross-sectional and longitudinal analyses. American Journal of Primatology 83(3):e23214, 2021. e-Pub 2021. PMID: 33169860.
- Falcone, C, Penna, E, Hong, T, Tarantal, AF, Hof, PR, Hopkins, WD, Sherwood, CC, Noctor, SC, Martínez-Cerdeño, V. Cortical Interlaminar Astrocytes Are Generated Prenatally, Mature Postnatally, and Express Unique Markers in Human and Nonhuman Primates. Cerebral Cortex 31(1):379-395, 2021. e-Pub 2021. PMID: 32930323.
- Hopkins WD, Staes N, Mulholland MM, Schapiro SJ, Rosenstein M, Stimpson C, Bradley BJ, & Sherwood CC. Gray matter variation in the posterior superior temporal gyrus is associated with polymorphisms in the KIAA0319 gene in chimpanzees (Pan troglodytes). eNeuro 8(6), 2021. e-Pub 2021. PMID: 34815295.
- Mulholland MM, Webb SJN, Mareno MC, Schweller KG, Schapiro SJ, & Hopkins WD. Are conspecific social videos rewarding to chimpanzees (Pan troglodytes)? A test of the social motivation theory. PlosOne 16(11):e0259941, 2021. e-Pub 2021. PMID: 34818358.
- Hirter K, Miller EN, Stimpson CD, Phillips KA, Hopkins WD, Hof PR, Sherwood CC, Lovejoy CO, & Raghanti MA. The human ventral striatum is characterized by increased dopaminergic innervation compared to other primates. Brain Structure and Function 226(6):1909-1923, 2021. e-Pub 2021.
- Bennett AJ, Pierre PJ, Wesley MJ, Latzman R, Schapiro SJ, Mareno MC, Bradley BJ, Sherwood CC, Mulholland MM, & Hopkins WD. Predicting their past: Machine language learning can discriminate the brains of chimpanzees with different early-life rearing experiences. Developmental Science 24(6):e13114, 2021. e-Pub 2021. PMID: 34180109.
- Neal Webb SJ, Schapiro SJ, Sherwood CC, Raghanti M, Hopkins WD. Neutrophil to lymphocyte ratio (NLR) in captive chimpanzees (Pan troglodytes): The effects of sex, age and rearing. PlosOne 15(12):e0244092, 2020. e-Pub 2020. PMID: 33326497.
- Miller JA, Voorhies WI, Li X, Raghuram I, Palomero-Gallagher N, Zilles K, Sherwood CC, Hopkins WD, Weiner KS. Sulcal morphology of the ventral temporal cortex is shared between humans and other hominoids. Scientific Reports 10(1):17132, 2020. e-Pub 2020. PMID: 33051475.
- Guevara EE, Lawler RR, Staes N, White CM, Sherwood CC, Ely JJ, Hopkins WD, Sherwood CC. Age-associated epigenetic changes in chimpanzees and humans. Philosophical Transactions of the Royal Society B: Biological Sciences 375(1811), 2020. e-Pub 2020. PMID: 32951551.
- Vickery S, Hopkins WD, Sherwood CC, Schapiro SJ, Latzman RD, Caspers S, Gaser C, Eickhoff SB, Dahnke R, Hoffstaedter F. Chimpanzee brain morphometry utilizing standardized MRI preprocessing and microanatomical annotations. ELife 9:1-20, 2020. e-Pub 2020. PMID: 33226338.
- Spocter MA, Sherwood CC, Schapiro SJ, Hopkins WD. Reproducibility of leftward planum temporale asymmetries in two genetically isolated populations of chimpanzees (Pan troglodytes). Proceedings of the Royal Society: of London: Biological Sciences B 287(1934), 2020. e-Pub 2020. PMID: 32900313.
- Mullholland MM, Mahovetz LM, Mareno MC, Reamer LA, Schapiro SJ, Hopkins WD. Differences in mutual eye gaze of bonobos (Pan paniscus) and chimpanzees (Pan troglodytes). Journal of Comparative Psychology 134(3):318-322, 2020. e-Pub 2020. PMID: 32804530.
- Balezeau F, Wilson B, Gallardo G, Dick F, Hopkins WD, Anwander A, Friederici AD, Griffiths TD, Petkov CI. Primate auditory prototype in the evolution of the arcuate fasciculus. Nature Neuroscience 23(5):611-614, 2020. e-Pub 2020. PMID: 32313267.
- Mullholland MM, Navabpour S, Mareno MC, Schapiro SJ, Young LY, Hopkins WD. AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees. Genes, Brain and Behavior 19(4):e12631, 2020. e-Pub 2020. PMID: 31894656.
- Grasby KL, WD Hopkins, et al. The genetic architecture of the human cerebral cortex. Science 367(6484), 2020. e-Pub 2020. PMID: 32193296.
- Loh, KK, Procyk, E, Neveu, R, Lamberton, F, Hopkins, WD, Petrides, M, Amiez, C. Cognitive control of orofacial motor and vocal responses in the ventrolateral and dorsomedial human frontal cortex. Proceedings of the National Academy of Sciences of the United States of America 117(9):4994-5005, 2020. e-Pub 2020. PMID: 32060124.
- Hopkins WD, Mullholland MM, Reamer LA, Mareno MC, Schapiro SJ. The role of early social rearing, neurological and genetic factors on individual differences in mutual eye gaze among captive chimpanzees. Scientific Reports 10(1):7412, 2020. e-Pub 2020.
- Loh KK, Procyk E, Neveu R, Lamberton F, Hopkins WD, Petrides M, Amiez C. Cognitive control of orofacial motor and vocal responses in the ventrolateral and dorsomedial human frontal cortex. Proceedings of the National Academy of Sciences 117(9):4994-5005, 2020. e-Pub 2020.
- Amiez C, Sallet J, Hopkins WD, Meguerditchian A, Hadj-Bouziane F, BenHamed S, Wilson C, Procyk E, Petrides M. Sulcal organization in the medial frontal cortex reveals insights into primate brain evolution. Nature Communications 10(1):3437, 2019. e-Pub 2019. PMID: 31366944.
- Mangin JF, Le Guen Y, Labra N, Grigis A, Frouin V, Guevara M, Fischer C, Riviere D, Hopkins WD, Regis J, Sun ZY. “Plis de passage” deserve a role in models of cortical folding processes. Brain Topography 32(6):1035-1048, 2019. e-Pub 2019. PMID: 31583493.
- Krachun C, Lurz R, Mahovetz LM, Hopkins WD. Mirror self-recognition and its relationship to social cognition in chimpanzees. Animal Cognition 22(6):1171-1183, 2019. e-Pub 2019. PMID: 31542841.
- Singh S, Staes N, Guevara E, Schapiro SJ, Ely J, Hopkins WD, Sherwood CC, Bradley B. Evolution of ASPM coding variation in apes and associations with brain structure in chimpanzees. Genes, Brain and Behavior 18(7):e12582, 2019. e-Pub 2019. PMID: 31119860.
- Hopkins WD, Latzman RD, Mahovetz LM, Li X, Roberts N. Investigating individual differences in chimpanzee mirror self-recognition and cortical thickness: A vertex-based and region-of-interest analysis. Cortex 118:306-314, 2019. e-Pub 2019. PMID: 31204008.
- Margiotoudi K, Marie D, Claidière N, Coulon O, Roth M, Nazarian B, Lacoste R, Hopkins WD, Molesti S, Fresnais P, J-L A, Meguerditchian A. Handedness in monkeys reflects hemispheric specialization within the central sulcus. An in vivo MRI study in right- versus left-handed baboons (Papio anubis). Cortex 118:203-211, 2019. e-Pub 2019. PMID: 30738569.
- Staes N, Smaers JB, Kunkle AE, Hopkins WD, Bradley BJ, Sherwood CC. Evolutionary divergence of neuroanatomical organization and related genes in chimpanzees and bonobos. Cortex 118:154-164, 2019. e-Pub 2019. PMID: 31422793.
- Hopkins WD, Latzman RD, Mareno MC, Schapiro SJ, Gomez-Robles A, Sherwood CC. Heritability in gray matter structural covariation and tool use skills in chimpanzees (Pan troglodytes): A sourced-based and quantitative genetic analysis. Cerebral Cortex 29(9):3702-3711, 2019. e-Pub 2019. PMID: 30307488.
- Leavens DA, Bard KA, Hopkins WD. The mismeasure of ape social cognition. Anim Cogn 22(4):487-504, 2019. e-Pub 2019. PMID: 28779278.
- Staes N, Sherwood CC, Freeman H, Brosnan SF, Schapiro SJ, Hopkins WD, & Bradley BJ. Serotonin receptor 1a variation is associated with anxiety and agonistic behavior in chimpanzees. Molecular Biology and Evolution 36(7):1418-1429, 2019. e-Pub 2019. PMID: 31045220.
- Falcone C, Wolf-Ochoa M, Amina S, Hong T, Vakilzadeh G, Hopkins WD, Hof PR, Sherwood CC, Manger PR, Noctor SC, Martínez-Cerdeño V. Cortical interlaminar astrocytes across the therian mammal radiation. Journal of Comparative Neurology 527(10):1654-1674, 2019. e-Pub 2019. PMID: 30552685.
- Bailoo JD, Quinius B, Schapiro SJ, Hopkins WD, Bennett AJ. Free-standing bipedal posture and coordinated bimanual manipulation significantly influence lateralized hand use in rhesus monkeys (Macaca mulatta) and chimpanzees (Pan troglodytes). J Comp Psychol 133(2):171-182, 2019. e-Pub 2019. PMID: 30372106.
- Issa HA, Staes N, Diggs-Galligan S, Stimpson CD, Gendron-Fitzpatrick A, Taglialatela JP, Hof PR, Hopkins WD, Sherwood CC. Comparison of bonobo and chimpanzee brain microstructure reveals differences in socio-emotional circuits. Brain Structure and Function 224(1):239-251, 2019. e-Pub 2019. PMID: 30306256.
- Alatorre WJL, Ponce de Leon MS, Hopkins WD, Zollikofer CPE. Evidence of independent brain and neurocranial reorganization during hominin evolution. Proceedings of the National Academy of Sciences 116(44):22115-22121, 2019. e-Pub 2019. PMID: 32193296.
- Hopkins WD, Mareno MC, Schapiro SJ. Further evidence of a left hemisphere specialization and genetic basis for tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations. Journal of Comparative Psychology 133(4):512-519, 2019. e-Pub 2019. PMID: 31246047.
- Hopkins WD, Li X, Roberts N. More intelligent chimpanzees (Pan troglodytes) have larger brains and increased cortical thickness. Intelligence 74:18-24, 2019. e-Pub 2019.
- Edler M, Sherwood C, Meindl R, Munger E, Hopkins WD, Ely J, Erwin J, Perl D, Mufson E, Hof P, Raghanti MA. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. J Comp Neurol 526(18):2921-2936, 2018. e-Pub 2018. PMID: 30069930.
- Altschul DM, Hopkins WD, Herrelko ES, Inoue-Murayama M, Matsuzawa T, King JE, Weiss A. Personality links with lifespan in chimpanzees. Elife 7:e33781, 2018. e-Pub 2018. PMID: 30296994.
- Regaiolli B, Spiezo C, Hopkins WD. Asymmetries in mother-infant behavior in Barbary macaques (Macaca sylvanus). Peer J 2018(5), 2018. e-Pub 2018. PMID: 29761052.
- Marie D, Roth M, Lacoste R, Nazarian B, Bertello A, Anton JL, Hopkins WD, Margiotoudi K, Love SA, Meguerditchian A. Left brain asymmetry of the panum temporale in a non-hominid primate: Redefining the origin of brain specialization for language. Cereb Cortex 28(5):1808-1815, 2018. e-Pub 2018. PMID: 28431000.
- Falk D, Zollikofer CPE, Ponce de Leon M, Semendeferi K, Warren JLA, Hopkins WD. Identifications of in vivo sulci on the external surfaces of eight adult chimpanzee brains: Implications for interpreting early hominin endocasts. Brain Behav Evol 91(1):45-58, 2018. e-Pub 2018. PMID: 29533941.
- Bard KA, Hopkins WD. Early socio-emotional intervention mediates long-term effects of atypical rearing on structural co-variation in gray matter in adult chimpanzees. Psychol Sci 29(4):594-603, 2018. e-Pub 2018. PMID: 29381427.
- Pope SM, Taglialatela JP, Skiba SA, Hopkins WD. Changes in frontoparietotemporal connectivity in following do-as-I-do training in chimpanzees (Pan troglodytes). J Cogn Neurosci 30(3):421-431, 2018. e-Pub 2018. PMID: 29211652.
- Regaiolli B, Rizzo M, Hopkins WD. Hand preference on unimanual and bimanual tasks in Basrbary macaques (Macaca sylvanus). Am J Primatol 80(3):22745, 2018. e-Pub 2018. PMID: 29457635.
- Beran MJ, Hopkins WD. Self-control in chimpanzees (Pan troglodytes) relates to general intelligence. Curr Biol 28(4):574-579.e3, 2018. e-Pub 2018. PMID: 29429613.
- Li X, Crow TJ, Hopkins WD, Gong Q, Roberts N. Human torque is not present in chimpanzee brain. Neuroimage 165:285-293, 2018. e-Pub 2018. PMID: 29031530.
- Lurz R, Krachun K, Mahovetz L, Hopkins WD. Chimpanzees gesture to humans in mirrors: Using reflection to dissociate seeing from line of gaze. Animal Behaviour 135:239-249, 2018. e-Pub 2018.
- Staes N, Bradley BJ, Hopkins WD, Sherwood C. Genetic signatures of socio-communicative abilities in primates. Current Opinion in Behavioral Sciences 21:33-38, 2018. e-Pub 2018.
- Staes N, Sherwood C, Wright K, deManuel M, Guevara EE, Marques-Bonet T, Kruetzen M, Massiah M, Hopkins WD, Ely JJ, Bradley BJ. FOXP2 variation in great ape populations offers insight into the evolution of communication skills. Sci Rep 7(1):16866, 2017. e-Pub 2017. PMID: 29203828.
- Edler MK, Sherwood CS, Meindl RS, Hopkins WD, Ely JJ, Erwin JM, Mufson EJ, Hof PR, Raghanti MA. Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease. Neurobiology of Aging 59:107-120, 2017. e-Pub 2017. PMID: 28888720.
- Loh KK, Petrides M, Hopkins WD, Procyk E, Amiez C. Cognitive control of vocalizations in the primate ventrolateral-dorsomedial (VLF-DMF) brain network. Neurosci Biobehav Rev 82:32-44, 2017. e-Pub 2017. PMID: 27923733.
- Muntane G, Santpere G, Verendeev A, Seely WW, Jacobs B, Hopkins WD, Navarro A, Sherwood CS. Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys. Brain Struct Funct 222(7):1-14, 2017. e-Pub 2017. PMID: 28317062.
- Latzman RD, Patrick CJ, Freemen HJ, Schapiro SJ, Hopkins WD. Triarchic psychopathy dimensions in chimpanzees (Pan troglodytes): Investigating associations with genetic variation in the vasopressin receptor 1A gene. Front Neurosci 11(JUL), 2017. e-Pub 2017. PMID: 28769746.
- Morino L, Uchikoshi M, Bercovitch F, Hopkins WD, Matsuzawa T. Tube task hand preference in captive hylobatids. Primates 58(3):403-421, 2017. e-Pub 2017. PMID: 28342054.
- Hopkins WD, Coulon O, Megurditchian A, Autrey M, Davidek K, Mahovetz LM, Pope S, Mareno MC, Schapiro SJ. Genetic factors and oro-facial motor learning selectively influence variability in central sulcus morphology in chimpanzees (Pan troglodytes). J Neurosci 37(22):5475-5483, 2017. e-Pub 2017. PMID: 28473646.
- Latzman RD, Hopkins WD. Etiology of triarchic psychopathy dimensions in chimpanzees (Pan troglodytes). Clin Psychol Sci 5(2):341-354, 2017. e-Pub 2017. PMID: 28503367.
- Hopkins WD, Meguerditchian A, Coulon O, Misiura M, Pope S, Mareno MC, Schapiro SJ. Motor skill for tool-use is associated with asymmetries in Broca's area and the motor hand area of the precentral gyrus in chimpanzees (Pan troglodytes). Behav Brain Res 318:71-81, 2017. e-Pub 2017. PMID: 27816558.
- Stephenson A, Edler M, Erwin J, Jacobs R, Hopkins WD, Hof P, Sherwood C, Raghanti MA. Cholinergic innervation of the basal ganglia in humans and other anthropoid primates. J Comp Neurol 525(2):319-332, 2017. e-Pub 2017. PMID: 27328754.
- Hecht EE, Mahovetz LM, Preuss TM, Hopkins WD. A neuroanatomical predictor of mirror self-recognition in chimpanzees. Soc Cogn Affect Neurosci 12(1):37-48, 2017. e-Pub 2017. PMID: 27803287.
- Hopkins WD, Li X, Crow TJ, Roberts N. Vertex- and atlas-based comparisons in measures of cortical thickness, gyrification and white matter volume between humans and chimpanzees. Brain Structure and Function 222(1):229-245, 2017. e-Pub 2017. PMID: 27100220.
- Gomez-Robles A, Hopkins WD, Schapiro SJ, Sherwood CC. The heritability of chimpanzee and human brain asymmetry. Proc Biol Sci 283(1845), 2016. e-Pub 2016. PMID: 28003442.
- Hopkins WD, Hopkins AM, Misiura M, Latash EM, Mareno MC, Schapiro SJ, Phillips KA. Sex differences in the relationship between planum temporale asymmetry and corpus callosum morphology in chimpanzees (Pan troglodytes): A combined MRI and DTI analysis. Neuropsychologia 93:325-334, 2016. e-Pub 2016. PMID: 27055947.
- Sanz CM, Morgan DB, Hopkins WD. Lateralization and performance asymmetries in termite fishing of wild chimpanzees in the Goualougo Triangle, Republic of Congo. Am J Primatol 78(11):1190-1200, 2016. e-Pub 2016. PMID: 27310151.
- Regaiolli B, Rizzo M, Hopkins WD. Hand preference on unimanual and bimanual tasks in strepsirrhines: The case of the ring-tailed lemur. Am J Primatol 78(8):851-860, 2016. e-Pub 2016. PMID: 27078687.
- Regaiolli B, Spiezo C, Hopkins WD. Three actions, two groups: Looking for the origin of primate manual lateralization. J Comp Psychol 130(3):259-268, 2016. e-Pub 2016. PMID: 27124402.
- Raghanti MA, Edler M, Stephenson A, Wilson L, Hopkins WD, Ely J, Erwin J, Jacobs B, Hof P, Sherwood C. Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: a comparative analysis of the primate basal ganglia. J Comp Neurol 524(10):2117-2129, 2016. e-Pub 2016. PMID: 26715195.
- Mahovetz L, Young L, Hopkins WD. The influence of AVPR1A genotype on individual differences in behaviors during a mirror self-recognition task in chimpanzees. Genes, Brain Behav 15(5):445-452, 2016. e-Pub 2016. PMID: 27058969.
- Latzman RD, Sauvigne K, Hopkins WD. Translating chimpanzee personality to humans: Investigating the transportability of chimpanzee-derived personality scales to humans. Am J Primatol 78(6):601-609, 2016. e-Pub 2016. PMID: 26716761.
- Krachun C, Lurz R, Russell JL, Hopkins WD. Smoke and mirrors: Testing the scope of chimpanzee's appearance-reality understanding. Cognition 150:53-67, 2016. e-Pub 2016. PMID: 26848736.
- Stimpson CD, Hopkins WD, Taglialatela JP, Barger N, Hof PR, Sherwood CC. Differential serotonergic innervation of the amygdala in bonobos and chimpanzees. Soc Cogn Affect Neurosci 11(3):413-422, 2016. e-Pub 2016. PMID: 26475872.
- Latzman RD, Young LJ, Hopkins WD. Displacement behaviors in chimpanzees (Pan troglodytes): A neurogenomics investigation of the RDoC negative valence systems domain. Psychophysiology 53(3):355-363, 2016. e-Pub 2016. PMID: 26877126.
Invited Articles
- Reyes LD, Kim YD, Issa H, Hopkins WD, Mackey S, & Sherwood CC. Cytoarchitecture, myeloarchitecture and parcellation of the chimpanzee inferior parietal lobe. Brain Structure and Function 228(1):63-82, 2023. e-Pub 2023. PMID: 35676436.
- Hopkins WD. Neuroanatomical asymmetries in nonhuman primates in the homologs to Broca's and Wernicke's areas: A mini-review. Emerging Topics in Life Sciences 6(3):271-284, 2022. e-Pub 2022. PMID: 36073786.
- Lacreuse A, Raz N, Schmidtke D, Hopkins WD, Herndon J. Age-related decline in executive function as a hallmark of cognitive aging across primates: A view from the laboratory. Philosophical Transactions of the Royal Society B: Biological Sciences 375(1811), 2020. e-Pub 2020. PMID: 32951543.
- Edler MK, Munger EL, Meindl RS, Hopkins WD, Ely JJ, Erwin JE, Mufson EJ, Hof PR, Sherwood CC, Raghanti M. Age-related neuron density changes in chimpanzee brains with Alzheimer’s disease pathology. Philosophical Transactions of the Royal Society B: Biological Sciences 375(1811), 2020. e-Pub 2020. PMID: 32951541.
- Hopkins WD. A review of performance asymmetries in hand skill in nonhuman primates with a special emphasis in chimpanzees. Prog Brain Res 238:57-89, 2018. e-Pub 2018. PMID: 30097203.
Other Articles
- Mulholland MM, Whitham W, Berkey M, Pytka LM, Pierre P, Hopkins WD Implementation of automated cognitive testing systems for socially housed rhesus (Macaca mulatta) and squirrel (Saimiri spp.) monkeys: Age differences in learning. J Comp Psychol. PMID: 39250237.
- Vickery S, Patil KR, Dahnke R, Hopkins WD, Sherwood CC, Caspers S, Eickhoff SB, Hoffstaedter F The uniqueness of human vulnerability to brain aging in great ape evolution. Sci Adv 10(35). PMID: 39196942.
- Chauvel M, Pascucci M, Uszynski I, Herlin B, Mangin JF, Hopkins WD, Poupon C Comparative analysis of the chimpanzee and human brain superficial structural connectivities. Brain Struct Funct 229(8):1943-1977. PMID: 39020215.
Book Chapters
- Hopkins, WD. Cognitive and Neuroanatomical Foundations of Individual Differences in Mirror Self-Recognition in Chimpanzees, 29-49, 2023.
- Hopkins WD, Sherwood CC. Genetic and environmental influences on chimpanzee brain and cognition. In: Primate Cognitive Studies. Cambridge University Press, 29-56, 2022.
- Hopkins, WD, Latzman, RD. Role of oxytocin and vasopressin v1a receptor variation on personality, social behavior, social cognition, and the brain in nonhuman primates, with a specific emphasis on chimpanzees, 134-160, 2021.
- Hopkins WD. Motor and communicative correlates of inferior frontal gyrus (Broca's area) in chimpanzees. In: Evolution of language: Continuities and discontinuities in nonhuman primates. Springer-Verlag, 2018.
- Hopkins WD, Latzman RD. Future research with captive chimpanzees in the USA: Integrating scientific program with behavioral management. In: Handbook of Primate Behavioral Management. Taylor and Francis Group, 445-470, 2017.
- Hopkins WD, Stimpson CD, Sherwood CC. Social cognition and brain organization in chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). In: Bonobos: Unique in Mind, Brain and Behavior. Oxford University Press, 2017.
Books (edited and written)
- Keenan, JP, Quevedo, K, Hopkins, WD. Self-Face Recognition and the Brain: How the Neuroscience of Mirror Recognition Has Changed Psychology, Psychiatry, and Evolution, 2023.
- Forrester GS, Hopkins WD, Hudry K, Lindell A. Cerebral Lateralization and Cognition: Evolutionary and Developmental Investigations of Behavioral Biases. Cambridge University Press, 2018.
- Hopkins WD. Evolution of hemispheric specialization in primates. Academic Press, 2007.
- Fagot J, Rogers L, Ward JP, Bulman-Fleming B, Hopkins WD. Hemispheric Specialization in Animals and Humans: A Special Issue of Laterality. Psychology Press, 1997.
- Ward JP, Hopkins WD. Primate Laterality: Current Behavioral Evidence of Primate Asymmetries. Springer-Verlag, 1993.
Letters to the Editor
- Latzman RD, Hopkins WD. Letter to the editor: Avoiding a lost opportunity for psychological medicine: importance of chimpanzee research to the National Institutes of Health portfolio. Psychol Med 46: 2445-2447, 2016.
Patient Reviews
CV information above last modified March 10, 2026