William G. Wierda, M.D., Ph.D.

Peer-Reviewed Articles

1. Chiu CY, Ahmed S, Thomas SK, Wang LS, Mustafayev K, Fayad LE, Wierda WG, Khawaja F, Torres HA. Hepatitis B Virus Reactivation in Patients Receiving Bruton Tyrosine Kinase Inhibitors. Clin Lymphoma Myeloma Leuk 23(8):610-615, 2023. e-Pub 2023. PMID: 37150651.
2. Thompson PA, Bazinet A, Wierda WG, Tam CS, O'Brien SM, Saha S, Peterson C, Plunkett W, Keating M. Sustained remissions in CLL after frontline FCR treatment with very long-term follow-up. Blood, 2023.
3. Bazinet A, Kadia T, Short NJ, Borthakur G, Wang SA, Wang W, Loghavi S, Jorgensen J, Patel K, DiNardo C, Daver N, Alvarado Y, Haddad FG, Pierce S, Nogueras Gonzalez G, Maiti A, Sasaki K, Yilmaz M, Thompson P, Wierda W, Garcia-Manero G, Andreeff M, Jabbour E, Konopleva M, Huang X, Kantarjian H, Ravandi F. Undetectable Measurable Residual Disease is Associated with Improved Outcomes in AML Irrespective of Treatment Intensity. Blood Adv 7(13):3284-3296, 2023. e-Pub 2023. PMID: 36884300.
4. Gordon MJ, Jones JE, George B, Peterson C, Burger JA, Jain N, Keating M, Wierda WG, Durand JB, Ferrajoli A. Long-term outcomes in patients with chronic lymphocytic leukemia treated with ibrutinib: Focus on hypertension and cardiovascular toxicity. Cancer 129(14):2192-2200, 2023. e-Pub 2023. PMID: 37016930.
5. Allan JN, Flinn IW, Siddiqi T, Ghia P, Tam CS, Kipps TJ, Barr PM, Elinder Camburn A, Tedeschi A, Badoux XC, Jacobs R, Kuss BJ, Trentin L, Zhou C, Szoke A, Abbazio C, Wierda WG. Outcomes in Patients with High-Risk Features after Fixed-Duration Ibrutinib plus Venetoclax: Phase II CAPTIVATE Study in First-Line Chronic Lymphocytic Leukemia. Clin Cancer Res 29(14):OF1-OF9, 2023. e-Pub 2023. PMID: 37282671.
6. El Hussein S, Medeiros LJ, Gruschkus SK, Wei P, Schlette E, Fang H, Jelloul FZ, Wang W, Fiskus W, Kanagal-Shamanna R, Loghavi S, Yang H, Li S, Xu J, Tang Z, Thakral B, Jain N, Wierda WG, Patel K, Bhalla KN, Khoury JD. Immune evasion phenotype is common in Richter transformation diffuse large B-cell lymphoma variant. Virchows Arch 482(6):1011-1019, 2023. e-Pub 2023. PMID: 36864257.
7. Jabbour E, Short NJ, Senapati J, Jain N, Huang X, Daver N, DiNardo CD, Pemmaraju N, Wierda W, Garcia-Manero G, Montalban Bravo G, Sasaki K, Kadia TM, Khoury J, Wang SA, Haddad FG, Jacob J, Garris R, Ravandi F, Kantarjian HM. Mini-hyper-CVD plus inotuzumab ozogamicin, with or without blinatumomab, in the subgroup of older patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: long-term results of an open-label phase 2 trial. Lancet Haematol 10(6):e433-e444, 2023. e-Pub 2023. PMID: 37187201.
8. El Hussein S, Medeiros LJ, Lyapichev KA, Fang H, Jelloul FZ, Fiskus W, Chen J, Wei P, Schlette E, Xu J, Li S, Kanagal-Shamanna R, Yang H, Tang Z, Thakral B, Loghavi S, Jain N, Thompson PA, Ferrajoli A, Wierda WG, Jabbour E, Patel KP, Dabaja BS, Bhalla KN, Khoury JD. Immunophenotypic and genomic landscape of Richter transformation diffuse large B-cell lymphoma. Pathology 55(4):514-524, 2023. e-Pub 2023. PMID: 36933995.
9. Siddiqi T, Maloney DG, Kenderian SS, Brander DM, Dorritie K, Soumerai J, Riedell PA, Shah NN, Nath R, Fakhri B, Stephens DM, Ma S, Feldman T, Solomon SR, Schuster SJ, Perna SK, Tuazon SA, Ou SS, Papp E, Peiser L, Chen Y, Wierda WG. Lisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004): a multicentre, open-label, single-arm, phase 1-2 study. Lancet. e-Pub 2023. PMID: 37295445.
10. Roccograndi LM, Lovell AR, Ferrajoli A, Thompson PA, Burger JA, Wierda WG, Jain N, Rausch CR. Incidence of major bleeding in patients with chronic lymphocytic leukemia receiving ibrutinib and therapeutic anticoagulation. Leuk Lymphoma:1-8. e-Pub 2023. PMID: 37317991.
11. Thompson PA, Keating MJ, Ferrajoli A, Jain N, Peterson CB, Garg N, Wang SA, Jorgensen JL, Kadia TM, Bose P, Pemmaraju N, Short NJ, Wierda WG. Venetoclax consolidation in high-risk CLL treated with ibrutinib for =1 year achieves a high rate of undetectable MRD. Leukemia. e-Pub 2023. PMID: 37138019.
12. Jain N, Senapati J, Thakral B, Ferrajoli A, Thompson P, Burger J, Basu S, Kadia T, Daver N, Borthakur G, Konopleva M, Pemmaraju N, Parry E, Wu CJ, Khoury J, Bueso-Ramos C, Garg N, Wang X, Lopez W, Ayala A, O'Brien S, Kantarjian H, Keating M, Allison J, Sharma P, Wierda W. A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL. Blood Adv 7(10):1958-1966, 2023. PMID: 36287248.
13. Jain N, Senapati J, Thakral B, Ferrajoli A, Thompson P, Burger J, Basu S, Kadia T, Daver N, Borthakur G, Konopleva M, Pemmaraju N, Parry E, Wu CJ, Khoury J, Bueso-Ramos C, Garg N, Wang X, Lopez W, Ayala A, O’Brien S, Kantarjian H, Keating M, Allison J, Sharma P, Wierda W. A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL. Blood Advances 7(10):1958-1966, 2023.
14. Kantarjian H, Short NJ, Jain N, Sasaki K, Huang X, Haddad FG, Khouri I, DiNardo CD, Pemmaraju N, Wierda W, Garcia-Manero G, Kebriaei P, Garris R, Loghavi S, Jorgensen J, Kwari M, O'Brien S, Ravandi F, Jabbour E. Frontline combination of ponatinib and hyper-CVAD in Philadelphia chromosome-positive acute lymphoblastic leukemia: 80-months follow-up results. Am J Hematol 98(3):493-501, 2023. e-Pub 2023. PMID: 36600670.
15. Hoff FW, Griffen TL, Brown BD, Horton TM, Burger J, Wierda W, Hubner SE, Qiu Y, Kornblau SM. Reverse Phase Protein Array Profiling Identifies Recurrent Protein Expression Patterns of DNA Damage-Related Proteins across Acute and Chronic Leukemia: Samples from Adults and the Children's Oncology Group. Int J Mol Sci 24(6), 2023. e-Pub 2023. PMID: 36982537.
16. Griffen TL, Hoff FW, Qiu Y, Burger J, Wierda W, Kornblau SM. Prognostication of DNA Damage Response Protein Expression Patterns in Chronic Lymphocytic Leukemia. Int J Mol Sci 24(6), 2023. e-Pub 2023. PMID: 36982555.
17. Parry EM, Leshchiner I, Guièze R, Johnson C, Tausch E, Parikh SA, Lemvigh C, Broséus J, Hergalant S, Messer C, Utro F, Levovitz C, Rhrissorrakrai K, Li L, Rosebrock D, Yin S, Deng S, Slowik K, Jacobs R, Huang T, Li S, Fell G, Redd R, Lin Z, Knisbacher BA, Livitz D, Schneider C, Ruthen N, Elagina L, Taylor-Weiner A, Persaud B, Martinez A, Fernandes SM, Purroy N, Anandappa AJ, Ma J, Hess J, Rassenti LZ, Kipps TJ, Jain N, Wierda W, Cymbalista F, Feugier P, Kay NE, Livak KJ, Danysh BP, Stewart C, Neuberg D, Davids MS, Brown JR, Parida L, Stilgenbauer S, Getz G, Wu CJ. Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nat Med 29(1):158-169, 2023. e-Pub 2023. PMID: 36624313.
18. Tantawy SI, Sarkar A, Hubner S, Tan Z, Wierda WG, Eldeib A, Zhang S, Kornblau S, Gandhi V. Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies. Clin Cancer Res 29(2):446-457, 2023. PMID: 36346691.
19. Wierda WG, Kipps TJ, Al-Sawaf O, Chyla B, Biondo JML, Mun Y, Jiang Y, Seymour JF. Utility of measurable residual disease for predicting treatment outcomes with BCR- and BCL2-Targeted therapies in patients with CLL. Leuk Lymphoma 63(12):1-20, 2022. e-Pub 2022. PMID: 35983732.
20. Shah BD, Ghobadi A, Oluwole OO, Logan AC, Boissel N, Cassaday RD, Leguay T, Bishop MR, Topp MS, Tzachanis D, O'Dwyer KM, Arellano ML, Lin Y, Baer MR, Schiller GJ, Park JH, Subklewe M, Abedi M, Minnema MC, Wierda WG, DeAngelo DJ, Stiff P, Jeyakumar D, Dong J, Adhikary S, Zhou L, Schuberth PC, Faghmous I, Masouleh BK, Houot R. Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external historical control study. J Hematol Oncol 15(1):170, 2022. e-Pub 2022. PMID: 36494725.
21. Barr PM, Tedeschi A, Wierda WG, Allan JN, Ghia P, Vallisa D, Jacobs R, O'Brien S, Grigg AP, Walker P, Zhou C, Ninomoto J, Krigsfeld G, Tam CS. Effective Tumor Debulking With Ibrutinib Before Initiation of Venetoclax: Results From the CAPTIVATE Minimal Residual Disease (MRD) and Fixed-Duration (FD) Cohorts. Clin Cancer Res 28(20):4385-4391, 2022. e-Pub 2022. PMID: 35939599.
22. Wierda WG, Pagel JM, Davids MS, Zinzani PL, Lu Y, Liu H, Shahda S, Leow CC, Tam CS, Woyach J, Eyre TA, Mato AR. CLL-116 BRUIN CLL-322: A Phase 3 Open-Label, Randomized Study of Fixed-Duration Pirtobrutinib Plus Venetoclax and Rituximab Versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Trial in Progress). Clin Lymphoma Myeloma Leuk 22(Suppl 2):S267, 2022. PMID: 36163870.
23. Coombs CC, Pagel JM, Shah NN, Lamanna N, Munir T, Lech-Maranda E, Eyre TA, Woyach JA, Wierda WG, Cheah CY, Cohen JB, Roeker LE, Patel MR, Fakhri B, Barve MA, Tam CS, Lewis D, Gerson JN, Alencar A, Ujjani C, Flinn I, Sundaram S, Ma S, Jagadeesh D, Rhodes J, Taylor J, Abdel-Wahab O, Ghia P, Schuster SJ, Wang D, Nair B, Zhu E, Tsai DE, Davids MS, Brown JR, Jurczak W, Mato AR. CLL-120 Pirtobrutinib, A Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Previously Treated CLL/SLL: Updated Results from the Phase 1/2 BRUIN Study. Clin Lymphoma Myeloma Leuk 22(Suppl 2):S268-S269, 2022. PMID: 36163872.
24. Rozovski U, Veletik I, Harris D, Li P, Liu Z, Jain P, Manshouri T, Ferrajoli A, Burger J, Bose P, Thompson P, Jain N, Wierda W, Verstovsek S, Keating M, Estrov Z. CLL-162 PTX3 is Constitutively Active in CLL Cells. Clin Lymphoma Myeloma Leuk 22(Suppl 2):S271, 2022. PMID: 36163878.
25. Timofeeva N, Jain N, Irajizad E, Aslan B, Katayama H, Cai Y, Ayres M, Iles L, Vykoukal J, Dennison J, Hanash S, Wierda W, Gandhi V. CLL-532 Changes in Proteome of CLL (Chronic Lymphocytic Leukemia) Lymphocytes During Investigator-Initiated Trial of Ibrutinib Alone and in Combination With Venetoclax in Treatment-Naïve Patients With CLL. Clin Lymphoma Myeloma Leuk 22(Suppl 2):S283, 2022. PMID: 36163901.
26. Thompson PA, Jiang X, Banerjee P, Basar R, Garg N, Chen K, Kaplan M, Nandivada V, Cortes AKN, Ferrajoli A, Keating MJ, Peterson CB, Andreeff M, Rezvani K, Wierda WG. A phase two study of high dose blinatumomab in Richter's syndrome. Leukemia 36(9):2228-2232, 2022. e-Pub 2022. PMID: 35941212.
27. Cherng HJ, Khwaja R, Kanagal-Shamanna R, Tang G, Burger J, Thompson P, Ferrajoli A, Estrov Z, Sasaki K, Sampath D, Wang X, Kantarjian H, Keating M, Wierda WG, Jain N. TP53-altered CLL Treated with Firstline Bruton's Tyrosine Kinase Inhibitor-based Therapy: A Retrospective Analysis. Am J Hematol 97(8):1005-1012, 2022. e-Pub 2022. PMID: 35567779.
28. Tettamanti S, Rotiroti MC, Giordano Attianese GMP, Arcangeli S, Zhang R, Banerjee P, Galletti G, McManus S, Mazza M, Nicolini F, Martinelli G, Ivan C, Veliz Rodriguez T, Barbaglio F, Scarfò L, Ponzoni M, Wierda W, Gandhi V, Keating M, Biondi A, Caligaris-Cappio F, Biagi E, Ghia P, Bertilaccio MTS. Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia. Leuk Lymphoma 63(7):1566-1579, 2022. e-Pub 2022. PMID: 35259043.
29. Tam CS, Allan JN, Siddiqi T, Kipps TJ, Jacobs R, Opat S, Barr PM, Tedeschi A, Trentin L, Bannerji R, Jackson S, Kuss BJ, Moreno C, Szafer-Glusman E, Russell K, Zhou C, Ninomoto J, Dean JP, Wierda WG, Ghia P. Fixed-duration ibrutinib plus venetoclax for first-line treatment of CLL: primary analysis of the CAPTIVATE FD cohort. Blood 139(22):3278-3289, 2022. e-Pub 2022. PMID: 35196370.
30. Chen R, Chen Y, Xiong P, Zheleva D, Blake D, Keating MJ, Wierda WG, Plunkett W. Cyclin-dependent kinase inhibitor fadraciclib (CYC065) depletes anti-apoptotic protein and synergizes with venetoclax in primary chronic lymphocytic leukemia cells. Leukemia 36(6):1596-1608, 2022. e-Pub 2022. PMID: 35383271.
31. Rozovski U, Veletic I, Harris DM, Li P, Liu Z, Jain P, Manshouri T, Ferrajoli A, Burger JA, Bose P, Thompson PA, Jain N, Wierda WG, Verstovsek S, Keating MJ, Estrov Z. STAT3 Activates the Pentraxin 3 Gene in Chronic Lymphocytic Leukemia Cells. J Immunol 208(12):2847-2855, 2022. e-Pub 2022. PMID: 35595309.
32. Short NJ, Macaron W, Konopleva M, Ravandi F, Jain N, Issa GC, Kadia T, Sasaki K, Kebriaei P, Yilmaz M, Thompson PA, Takahashi K, Abbas HA, Wierda WG, Garris R, Kantarjian HM, Jabbour E. Dismal outcomes of patients with relapsed/refractory Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia after failure of both inotuzumab ozogamicin and blinatumomab. Am J Hematol 97(6):E201-E204, 2022. e-Pub 2022. PMID: 35266566.
33. Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H. NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022. J Natl Compr Canc Netw 20(6):622-634, 2022. PMID: 35714675.
34. Cacace F, Iula R, De Novellis D, Caprioli V, D'Amico MR, De Simone G, Cuccurullo R, Wierda WG, Mahadeo KM, Menna G, Tambaro FP. High-Risk Acute Myeloid Leukemia: A Pediatric Prospective. Biomedicines 10(6), 2022. e-Pub 2022. PMID: 35740427.
35. Vaca AM, Ioannou N, Sivina M, Vlachonikola E, Clise-Dwyer K, Kim E, Li D, Ma Q, Ferrajoli A, Estrov Z, Wierda WG, Patten PEM, Ramsay AG, Burger JA. Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures. Leukemia 36(5):1324-1335, 2022. e-Pub 2022. PMID: 35149845.
36. Jelloul FZ, Yang R, Garces S, Kanagal-Shamanna R, Ok CY, Loghavi S, Routbort MJ, Zuo Z, Yin CC, Floyd K, Bassett RL, Wierda W, Jain N, Thompson P, Luthra R, Medeiros LJ, Patel KP. Landscape of NOTCH1 mutations and co-occurring biomarker alterations in chronic lymphocytic leukemia. Leuk Res 116:106827, 2022. e-Pub 2022. PMID: 35430388.
37. Aslan B, Kismali G, Iles LR, Manyam GC, Ayres ML, Chen LS, Gagea M, Bertilaccio MTS, Wierda WG, Gandhi V. Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling in chronic lymphocytic leukemia. Blood Cancer J 12(5):80, 2022. e-Pub 2022. PMID: 35595730.
38. Sharman JP, Biondo JML, Boyer M, Fischer K, Hallek M, Jiang D, Kater AP, Porro Lurà M, Wierda WG. A review of the incidence of tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with venetoclax and debulking strategies. EJHaem 3(2):492-506, 2022. e-Pub 2022. PMID: 35846043.
39. Allan JN, Pinilla-Ibarz J, Gladstone DE, Patel K, Sharman JP, Wierda WG, Choi MY, O'Brien SM, Shadman M, Davids MS, Pagel JM, Yimer HA, Ward R, Acton G, Taverna P, Combs DL, Fox JA, Furman RR, Brown JR. Phase 1b dose-escalation study of the selective, noncovalent, reversible Bruton's tyrosine kinase inhibitor vecabrutinib in B-cell malignancies. Haematologica 107(4):984-987, 2022. e-Pub 2022. PMID: 34937320.
40. Sharman JP, Egyed M, Jurczak W, Skarbnik A, Pagel JM, Flinn IW, Kamdar M, Munir T, Walewska R, Corbett G, Fogliatto LM, Herishanu Y, Banerji V, Coutre S, Follows G, Walker P, Karlsson K, Ghia P, Janssens A, Cymbalista F, Woyach JA, Ferrant E, Wierda WG, Munugalavadla V, Yu T, Wang MH, Byrd JC. Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naïve chronic lymphocytic leukemia. Leukemia 36(4):1171-1175, 2022. e-Pub 2022. PMID: 34974526.
41. Mukherjee A, Milton DR, Jabbour EJ, Gulbis AM, Kadia T, Jain N, Ledesma C, Burger J, Ferrajoli A, Wierda W, Medeiros LJ, Kantarjian H, Champlin R, Khouri IF. Clinical outcome of allogeneic stem cell transplantation in patients with B-cell lymphoid malignancies following treatment with targeted small molecule inhibitors. Leuk Lymphoma 63(4):1-9, 2022. e-Pub 2022. PMID: 35225133.
42. van Dijk AD, Griffen TL, Qiu YH, Hoff FW, Toro E, Ruiz K, Ruvolo PP, Lillard JW, de Bont ESJM, Burger JA, Wierda W, Kornblau SM. RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences. Leukemia 36(3):712-722, 2022. e-Pub 2021. PMID: 34625713.
43. Ramos Perez JM, Patel KP, Loghavi S, Garcia-Manero G, Borthakur G, Jabbour E, Wierda W, Pierce S, Brandt M, Kornblau S, Kadia T, Daver N, DiNardo CD, Jain N, Yilmaz M, Short N, Verstovsek S, Ferrajoli A, Andreeff M, Konopleva M, Rivera D, McCue D, Kantarjian HM, Ravandi F. Value of measurable residual disease monitoring in patients with acute promyelocytic leukemia in the era of frontline 'chemotherapy-free' therapy. Leuk Lymphoma 63(3):1-4, 2022. e-Pub 2021. PMID: 34668451.
44. Siddiqi T, Soumerai JD, Dorritie KA, Stephens DM, Riedell PA, Arnason J, Kipps TJ, Gillenwater HH, Gong L, Yang L, Ogasawara K, Thorpe J, Wierda WG. Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL. Blood 139(12):1794-1806, 2022. e-Pub 2021. PMID: 34699592.
45. Jelloul FZ, Yang RK, Wang P, Garces S, Kanagal-Shamanna R, Ok CY, Loghavi S, Routbort MJ, Zuo Z, Yin CC, Floyd K, Bassett RL, Wierda WG, Jain N, Thompson PA, Luthra R, Medeiros LJ, Patel KP. Non-Coding NOTCH1 Mutations in Chronic Lymphocytic Leukemia Negatively Impact Prognosis. Am J Hematol 97(3):E100-E102, 2022. e-Pub 2022. PMID: 34989420.
46. Griffen TL, Hoff FW, Qiu Y, Lillard JW, Ferrajoli A, Thompson P, Toro E, Ruiz K, Burger J, Wierda W, Kornblau SM. Proteomic profiling based classification of CLL provides prognostication for modern therapy and identifies novel therapeutic targets. Blood Cancer J 12(3):43, 2022. e-Pub 2022. PMID: 35301276.
47. Galan-Cobo A, Stellrecht CM, Yilmaz E, Yang C, Qian Y, Qu X, Akhter I, Ayres ML, Fan Y, Tong P, Diao L, Ding J, Giri U, Gudikote J, Nilsson M, Wierda WG, Wang J, Skoulidis F, Minna JD, Gandhi V, Heymach JV. Enhanced vulnerability of LKB1-deficient NSCLC to disruption of ATP pools and redox homeostasis by 8-Cl-Ado. Mol Cancer Res 20(2):280-292, 2022. e-Pub 2021. PMID: 34654720.
48. Aslan B, Hubner SE, Fox JA, Taverna P, Wierda WG, Kornblau SM, Gandhi V. Vecabrutinib inhibits B-cell receptor signal transduction in chronic lymphocytic leukemia cell types with wild-type or mutant Bruton's tyrosine kinase. Haematologica 107(1):292-297, 2022. e-Pub 2022. PMID: 34498444.
49. Kantarjian HM, Jain N, Garcia-Manero G, Welch MA, Ravandi F, Wierda WG, Jabbour EJ. The cure of leukemia through the optimist's prism. Cancer 128(2):240-259, 2022. e-Pub 2021. PMID: 34614211.
50. Yi X, Jain N, Iles LR, Ayres ML, Wierda WG, Gandhi V. Targeting Mcl-1 by AMG-176 During Ibrutinib and Venetoclax Therapy in Chronic Lymphocytic Leukemia. Front Oncol 12:833714, 2022. e-Pub 2022. PMID: 35273915.
51. Jain N, Thompson P, Burger J, Ferrajoli A, Takahashi K, Estrov Z, Borthakur G, Bose P, Kadia T, Pemmaraju N, Sasaki K, Konopleva M, Jabbour E, Garg N, Wang X, Kanagal-Shamanna R, Patel K, Wang W, Jorgensen J, Wang S, Lopez W, Ayala A, Plunkett W, Gandhi V, Kantarjian H, O'Brien S, Keating M, Wierda WG. Ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab (iFCG) regimen for chronic lymphocytic leukemia (CLL) with mutated IGHV and without TP53 aberrations. Leukemia 35(12):3421-3429, 2021. e-Pub 2021. PMID: 34007049.
52. Sivina M, Kim E, Wierda WG, Ferrajoli A, Jain N, Thompson P, Kantarjian H, Keating M, Burger JA. Ibrutinib induces durable remissions in treatment-naïve patients with CLL and 17p deletion/TP53 mutations. Blood 138(24):2589-2592, 2021. e-Pub 2021. PMID: 34521099.
53. Wierda WG, Allan JN, Siddiqi T, Kipps TJ, Opat S, Tedeschi A, Badoux XC, Kuss BJ, Jackson S, Moreno C, Jacobs R, Pagel JM, Flinn I, Pak Y, Zhou C, Szafer-Glusman E, Ninomoto J, Dean JP, James DF, Ghia P, Tam CS. Ibrutinib Plus Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia: Primary Analysis Results From the Minimal Residual Disease Cohort of the Randomized Phase II CAPTIVATE Study. J Clin Oncol 39(34):JCO2100807, 2021. e-Pub 2021. PMID: 34618601.
54. Eyre TA, Schuh A, Wierda WG, Brown JR, Ghia P, Pagel JM, Furman RR, Cheung J, Hamdy A, Izumi R, Patel P, Wang MH, Xu Y, Byrd JC, Hillmen P. Acalabrutinib monotherapy for treatment of chronic lymphocytic leukaemia (ACE-CL-001): analysis of the Richter transformation cohort of an open-label, single-arm, phase 1-2 study. Lancet Haematol 8(12):e912-e921, 2021. e-Pub 2021. PMID: 34735860.
55. De Novellis D, Cacace F, Caprioli V, Wierda WG, Mahadeo KM, Tambaro FP. The TKI Era in Chronic Leukemias. Pharmaceutics 13(12), 2021. e-Pub 2021. PMID: 34959482.
56. Tambaro FP, Singh H, Jones E, Rytting M, Mahadeo KM, Thompson P, Daver N, DiNardo C, Kadia T, Garcia-Manero G, Chan T, Shah RR, Wierda WG. Autologous CD33-CAR-T cells for treatment of relapsed/refractory acute myelogenous leukemia. Leukemia 35(11):3282-3286, 2021. e-Pub 2021. PMID: 33833386.
57. Wierda WG, Rawstron A, Cymbalista F, Badoux X, Rossi D, Brown JR, Egle A, Abello V, Cervera Ceballos E, Herishanu Y, Mulligan SP, Niemann CU, Diong CP, Soysal T, Suzuki R, Tran HTT, Wu SJ, Owen C, Stilgenbauer S, Ghia P, Hillmen P. Measurable residual disease in chronic lymphocytic leukemia: expert review and consensus recommendations. Leukemia 35(11):3059-3072, 2021. e-Pub 2021. PMID: 34168283.
58. Esposito CL, Van Roosbroeck K, Santamaria G, Rotoli D, Sandomenico A, Wierda WG, Ferrajoli A, Ruvo M, Calin GA, de Franciscis V, Catuogno S. Selection of a Nuclease-Resistant RNA Aptamer Targeting CD19. Cancers (Basel) 13(20), 2021. e-Pub 2021. PMID: 34680368.
59. Davids MS, Roberts AW, Kenkre VP, Wierda WG, Kumar A, Kipps TJ, Boyer M, Salem AH, Pesko JC, Arzt JA, Mantas M, Kim SY, Seymour JF. Long-term Follow-up of Patients with Relapsed or Refractory Non-Hodgkin Lymphoma Treated with Venetoclax in a Phase I, First-in-Human Study. Clin Cancer Res 27(17):4690-4695, 2021. e-Pub 2021. PMID: 34083230.
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84. Frei M, Aitken SL, Jain N, Thompson P, Wierda W, Kontoyiannis DP, DiPippo AJ. Incidence and characterization of fungal infections in chronic lymphocytic leukemia patients receiving ibrutinib. Leuk Lymphoma 61(10):1-4, 2020. e-Pub 2020. PMID: 32530347.
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117. Giacopelli B, Zhao Q, Ruppert AS, Agyeman A, Weigel C, Wu YZ, Gerber MM, Rabe KG, Larson MC, Lu J, Blachly JS, Rogers KA, Wierda WG, Brown JR, Rai KR, Keating M, Rassenti LZ, Kipps TJ, Zenz T, Shanafelt TD, Kay NE, Abruzzo LV, Coombes KR, Woyach JA, Byrd JC, Oakes CC. Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia. Blood 134(8):688-698, 2019. e-Pub 2019. PMID: 31292113.
118. Chen R, Zhu M, Chaudhari RR, Robles O, Chen Y, Skillern W, Qin Q, Wierda WG, Zhang S, Hull KG, Romo D, Plunkett W. Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia. Leukemia 33(7):1663-1674, 2019. e-Pub 2019. PMID: 30700841.
119. Wierda WG, Byrd JC, O'Brien S, Coutre S, Barr PM, Furman RR, Kipps TJ, Burger JA, Stevens DA, Sharman J, Ghia P, Flinn IW, Zhou C, Ninomoto J, James DF, Tam CS. Tumour debulking and reduction in predicted risk of tumour lysis syndrome with single-agent ibrutinib in patients with chronic lymphocytic leukaemia. Br J Haematol 186(1):184-188, 2019. e-Pub 2019. PMID: 30740654.
120. Roberts AW, Ma S, Kipps TJ, Coutre SE, Davids MS, Eichhorst B, Hallek M, Byrd JC, Humphrey K, Zhou L, Chyla B, Nielsen J, Potluri J, Kim SY, Verdugo M, Stilgenbauer S, Wierda WG, Seymour JF. Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables. Blood 134(2):111-122, 2019. e-Pub 2019. PMID: 31023700.
121. Wierda WG, Byrd JC, Davids MS, Furman RR, Cheson BD, Barr PM, Eradat H, Heffner L, Zhou L, Verdugo M, Potluri J, Choi M. Venetoclax for chronic lymphocytic leukaemia patients who progress after more than one B-cell receptor pathway inhibitor. Br J Haematol 185(5):961-966, 2019. e-Pub 2018. PMID: 30478940.
122. Hu B, Patel KP, Chen HC, Wang X, Wang F, Luthra R, Routbort MJ, Kanagal-Shamanna R, Medeiros LJ, Yin CC, Zuo Z, Ok CY, Loghavi S, Tang G, Tambaro FP, Thompson P, Burger J, Jain N, Ferrajoli A, Bose P, Estrov Z, Keating MJ, Wierda WG. Routine sequencing in CLL has prognostic implications and provides new insight into pathogenesis and targeted treatments. Br J Haematol 185(5):852-864, 2019. e-Pub 2019. PMID: 30924136.
123. Flinn IW, Gribben JG, Dyer MJS, Wierda W, Maris MB, Furman RR, Hillmen P, Rogers KA, Iyer SP, Quillet-Mary A, Ysebaert L, Walter HS, Verdugo M, Klein C, Huang H, Jiang Y, Lozanski G, Pignataro DS, Humphrey K, Mobasher M, Kipps TJ. Phase 1b study of venetoclax-obinutuzumab in previously untreated and relapsed/refractory chronic lymphocytic leukemia. Blood 133(26):2765-2775, 2019. e-Pub 2019. PMID: 30862645.
124. Paul S, Jain N, Ferrajoli A, O'Brien S, Burger J, Keating M, Wierda W. A phase II trial of eltrombopag for patients with chronic lymphocytic leukaemia (CLL) and thrombocytopenia. Br J Haematol 185(3):606-608, 2019. e-Pub 2018. PMID: 30406944.
125. Sasaki K, Kantarjian HM, O'Brien S, Ravandi F, Konopleva M, Borthakur G, Garcia-Manero G, Wierda WG, Daver N, Ferrajoli A, Takahashi K, Jain P, Rios MB, Pierce SA, Jabbour EJ, Cortes JE. Incidence of second malignancies in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitors. Int J Hematol 109(5):545-552, 2019. e-Pub 2019. PMID: 30830579.
126. Strati P, Takahashi K, Peterson CB, Keating MJ, Thompson PA, Daver NG, Jain N, Burger JA, Estrov Z, O'Brien SM, Kantarjian HM, Wierda WG, Futreal PA, Ferrajoli A. Efficacy and predictors of response of lenalidomide and rituximab in patients with treatment-naive and relapsed CLL. Blood Adv 3(9):1533-1539, 2019. PMID: 31076409.
127. Jain N, Keating M, Thompson P, Ferrajoli A, Burger J, Borthakur G, Takahashi K, Estrov Z, Fowler N, Kadia T, Konopleva M, Alvarado Y, Yilmaz M, DiNardo C, Bose P, Ohanian M, Pemmaraju N, Jabbour E, Sasaki K, Kanagal-Shamanna R, Patel K, Jorgensen J, Garg N, Wang X, Sondermann K, Cruz N, Wei C, Ayala A, Plunkett W, Kantarjian H, Gandhi V, Wierda W. Ibrutinib and Venetoclax for First-Line Treatment of CLL. N Engl J Med 380(22):2095-2103, 2019. PMID: 31141631.
128. Wierda WG. Does FCR have the potential to cure a subgroup of patients with chronic lymphocytic leukemia?. Clin Adv Hematol Oncol 17(4):214-216, 2019. PMID: 31188811.
129. Cervantes-Gomez F, Stellrecht CM, Ayres ML, Keating MJ, Wierda WG, Gandhi V. PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells. Oncotarget 10(29):2793-2809, 2019. e-Pub 2019. PMID: 31073371.
130. Boddu P, Thakral B, Alhuraiji A, Pemmaraju N, Kadia T, Ohanian M, Ravandi F, Jabbour E, Wierda W, Khoury JD, Jain N. Distinguishing thymoma from T-lymphoblastic leukaemia/lymphoma: a case-based evaluation. J Clin Pathol 72(3):251-257, 2019. e-Pub 2018. PMID: 30467242.
131. Burger JA, Sivina M, Jain N, Kim E, Kadia T, Estrov Z, Nogueras-Gonzalez GM, Huang X, Jorgensen J, Li J, Cheng M, Clow F, Ohanian M, Andreeff M, Mathew T, Thompson P, Kantarjian H, O'Brien S, Wierda WG, Ferrajoli A, Keating MJ. Randomized trial of ibrutinib versus ibrutinib plus rituximab in patients with chronic lymphocytic leukemia. Blood 133(10):1011-1019, 2019. e-Pub 2018. PMID: 30530801.
132. Nastoupil LJ, Lunning MA, Vose JM, Schreeder MT, Siddiqi T, Flowers CR, Cohen JB, Burger JA, Wierda WG, O'Brien S, Sportelli P, Miskin HP, Purdom MA, Weiss MS, Fowler NH. Tolerability and activity of ublituximab, umbralisib, and ibrutinib in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: a phase 1 dose escalation and expansion trial. Lancet Haematol 6(2):e100-e109, 2019. PMID: 30709431.
133. Kanagal-Shamanna R, Jain P, Patel KP, Routbort M, Bueso-Ramos C, Alhalouli T, Khoury JD, Luthra R, Ferrajoli A, Keating M, Jain N, Burger J, Estrov Z, Wierda W, Kantarjian HM, Medeiros LJ. Targeted multigene deep sequencing of Bruton tyrosine kinase inhibitor-resistant chronic lymphocytic leukemia with disease progression and Richter transformation. Cancer 125(4):559-574, 2019. e-Pub 2018. PMID: 30508305.
134. Wierda WG, Byrd JC, Abramson JS, Bilgrami SF, Bociek G, Brander D, Brown J, Chanan-Khan AA, Chavez JC, Coutre SE, Davis RS, Fletcher CD, Hill B, Kahl BS, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Malek S, Mato A, Mosse C, Neppalli VT, Shadman M, Siddiqi T, Stephens D, Wagner N, Dwyer MA, Sundar H. NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019. J Natl Compr Canc Netw 17(1):12-20, 2019. PMID: 30659125.
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Abstracts

1. Haddad F, Jabbour E, Zoghbi M, Short N, Senapati J, Macaron W, Nasnas C, Nasr L, Pemmaraju N, Jain N, Wierda WG, Borthakur G, Montalban-Bravo G, Ravandi F, Garcia-Manero G, Kadia T, Chien K, Thankachan J, Garris R, Kantarjian H. A Phase II Trial of Mini-Hyper-CVD with Venetoclax for Patients with Relapsed/Refractory (R/R) Philadelphia Chromosome (Ph)-Negative Acute Lymphoblastic Leukemia (All). EHA Library, 2023.
2. Siddiqi T, Maloney DG, Kenderian S, Brander DM, Dorritie KA, Soumerai J, Riedell PA, Shah NN, Nath R, Fakhri B, Stephens DM, Ma S, Feldman TA, Solomon SR, Schuster SJ, Perna SK, Ou S, Papp E, Chen Y, Wierda WG. Lisocabtagene maraleucel (liso-cel) in R/R chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Primary analysis of TRANSCEND CLL 004. Journal of Clinical Oncology 41(Supp 16):7501-7501, 2023. e-Pub 2023.
3. Barr PM, Allan JM, Tanya Siddiqi, Wierda WG, Lun Tam CS, Moreno CD, Tedeschi A, Szafer-Glusman E, Zhou C, Abbazio C, Dean JP, Szoke A, Ghia P. Fixed-duration ibrutinib + venetoclax for first-line treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): 4-y follow-up from the FD cohort of the phase 2 CAPTIVATE study. Journal of Clinical Oncology 41(supp 16):7535-7535, 2023. e-Pub 2023.
4. Eyre TA, Thompson P, Wierda WG, Šimkovič M, Grosicki S, Jurczak W, Wang Y, Móciková H, Zinzani PL, Lun Tam CS, Davids MS, Chang AE, Oliveira JM, Lu Y, Leow CC, Roeker LE, Woyach JA. BRUIN CLL-322: A phase 3 open-label, randomized study of fixed duration pirtobrutinib plus venetoclax and rituximab versus venetoclax and rituximab in previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma. Journal of Clinical Oncology 41(Supp 16):TPS7583-TPS7583, 2023. e-Pub 2023.
5. Woyach JA, Coombs CC, Lewis KL, Escalon MP, Ceccarelli M, Bian YF, Wierda WG. BRUIN CLL-314: A phase 3, open-label, randomized study of pirtobrutinib versus ibrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Journal of Clinical Oncology 41(Supp 16):TPS 7584-TPS7584, 2023. e-Pub 2023.
6. Zoghbi M, Jabbour E, Haddad F, Short NJ, Senapati J, Macaron W, Nasnas CC, Nasr LF, Pemmaraju N, Jain N, Wierda WG, Borthakur G, Bravo GM, Ravandi F, Garcia-Manero G, Kadia TM, Chien KS, Thankachan J, Garris R, Kantarjian HM. Mini-hyper-CVD with venetoclax (Ven) for patients with relapsed/refractory (R/R) Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL): A phase II study. Journal of Clinical Oncology 41(Supp 16):e19039-e19039, 2023. e-Pub 2023.
7. Siddiqi T, Maloney DG, Kenderian S, Brander DM, Dorritie KA, Soumerai J, Riedell PA, Shah NN, Nath R, Fakhri B, Stephens DM, Ma S, Feldman TA, Solomon SR, Schuster SJ, Perna SK, Ou SS, Papp E, Chen Y, Wierda WG. Lisocabtagene maraleucel (liso-cel) in R/R chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Primary analysis of TRANSCEND CLL 004. Journal of Clinnical Oncology 41(Suppl 16):7501-7501, 2023. e-Pub 2023.
8. Woyach JA, Wierda WG, Coombs CC, Lewis KL, Gribben JG, Escalon MP, Ceccarelli M, Wu X, Mato AR. BRUIN CLL-314: A Phase III Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Blood 140(Supplement 1):12427-12428, 2022. e-Pub 2022.
9. Parry EM, Guieze R, Leshchiner I, Johnson C, Tausch E, Parikh SA, Lemvigh CK, Broséus J, Hergalant S, Messer C, Utro F, Levovitz C, Rhrissorrakrai K, Li L, Li S, Fell, Robert A. Redd GG, Lin Z, Knisbacher BA, Schneider C, Fernandes SM, Hess JM, Rassenti LZ, Kipps TJ, Jain N, Wierda WG, Cymbalista F, Feugier P, Kay N, Livak KJ, Danysh BJ, Stewart C, Donna S. Neuberg, Davids MS, Brown JR, Parida L, Stilgenbauer S, Getz G, Wu C. Evolutionary History of Transformation from Chronic Lymphocytic Leukemia to Richter Syndrome. Blood 140(Supplement 1):1530-1533, 2022.
10. Jabbour E, Sasaki K, Issa GC, Haddad F, Garcia-Manero G, Kadia TM, Wierda WG, Yilmaz M, DiNardo CD, Skinner J, Pemmaraju N, Dellasala SE, Pierce SA, Cortes JE, Kantarjian H. Outcome of Third-Line Tyrosine Kinase Inhibitors in Patients with Chronic Myeloid Leukemia in Chronic Phase: A Propensity Score Analysis. Blood 140(Supp. 1):809-811, 2022.
11. Haddad FG, Kantarjian H, Short NJ, Konopleva M, Jain N, Huang X, Ravandi F, Wierda W, Borthakur G, Sasaki K, Issa G, Alvarado Y, Pemmaraju N, Garcia-Manero G, Thankachan J, Garris R, Jabbour E. Updated Results from the Phase II Study of Blinatumomab in Combination With Ponatinib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Clinical Lymphoma Myeloma and Leukemia 22(Supp. 2):S204, 2022.
12. Jain N, Keating MJ, Thompson PA, Ferrajoli A, Senapati J, Burger JA, Borthakur G, Takahashi K, Estrov ZE, Konopleva M, Sasaki K, Kadia TM, Pemmaraju N, Daver N, Jabbour E, DiNardo CD, Alvarado Y, Yilmaz M, Bose P, Ohanian M, Kanagal-Shamanna R, Patel K, Jorgensen JL, Wang SA, Nassar S, Garg N, Hwang H, Wang X, Cruz N, Ayala A, Plunkett W, Kantarjian H, Gandhi V, Wierda WG. Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 4-Year Follow-up Data. Blood 140(Supp 1):234-237, 2022.
13. Lee HJ, Choi MY, Siddiqi T, Rhodes JM, Wierda WG, Isufi I, Tuscano JM, Lamanna N, Subbiah S, Koff JL, Goldenberg A, GG, Breitmeyer JB, Yazji S, Wang M, Jamieson C, Kipps TJ. Phase 1/2 Study of Zilovertamab and Ibrutinib in Mantle Cell Lymphoma (MCL), Chronic Lymphocytic Leukemia (CLL), or Marginal Zone Lymphoma (MZL). Blood 140(Supp 1):666-568, 2022.
14. Tantawy SI, Aslan B, Chen LS, Iles L, Thompson PA, Jain N, Wierda WG, Gandhi V. Pharmacological Profiling of Cells from Patients with Chronic Lymphocytic Leukemia (CLL) Treated with Pirtobrutinib. Blood 140(Supp 1):501-502, 2022.
15. Lemvigh CK, Parry EM, Deng SL, Dangle NJ, Ruthen N, Knisbacher BA, Broséus J, Hergalant S, Guieze R, Li S, Yin S, Huang T, Livak KJ, Getz G, Neuberg DS, Feugier P, Kharchenko P, Wierda WG , Olsen LR, Jain N, Wu CJ. ZNF683 (Hobit) Marks a CD8+ T Cell Population Associated with Anti-Tumor Immunity Following Anti-PD-1 Therapy for Richter Syndrome. Blood 140(supp1):1807-1808, 2022.
16. Maiti A, DiNardo CD, Ohanian M, Pemmaraju N, Daver N, Borthakur G, Ravandi F, Issa GC, Garcia-Manero G, Jain N, Kadia TM, Masarova L, Wierda WG, Yilmaz M, Alvarado Y, Jabbour E, Short N, Takahashi K, Loghavi S, Patel KP, Montalbano K, Pierce SA, Bivins CA, Mehta RS, Alatrash G, Popat UR, Kebriaei P, Oran B, Shpall EJ, Champlin RE, Kantarjian H, Konopleva M. Long-Term Outcomes of Acute Myeloid Leukemia Following Allogeneic Stem-Cell Transplantation after Decitabine and Venetoclax: Subgroup Analysis of a Phase II Trial. Blood 140(Supp 1):7725-7728, 2022.
17. Mato AR, Wierda WG, Ai WZ, Flinn IW, Tees M, Patel MR, Patel K, O'Brien S, Bond DA, Roeker LE, Siddiqi T, Wang ML, Sun C, Abdel-Wahab O, Schwab A, Tan M, Meredith E, Gessner MA, Kim SY, Wiestner A, Danilov AV. NX-2127-001, a First-in-Human Trial of NX-2127, a Bruton's Tyrosine Kinase-Targeted Protein Degrader, in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia and B-Cell Malignancies. Blood 140(Supp 1):2329-2332, 2022.
18. Mato AR, Woyach JA, Brown JR, Ghia P, Patel K, Eyre TA, Munir T, Lech-Marańda E, Lamanna N, Tam CS, Seymour JF, Shah NN, Coombs CC, Ujjani CS, Patel MR, Fakhri B, Cheah CY, Alencar AJ, Cohen JB, Gerson JN, Flinn IW, Ma S, Jagadeesh D, Rhodes JM, Hernandez-Ilizaliturri F, Zinzani PL, Balbas M, Nair B, Abada PB, Wang C, Wang D, Tsai DE, Wierda WG, Jurczak W. Efficacy of Pirtobrutinib in Covalent BTK-Inhibitor Pre-Treated Relapsed / Refractory CLL/SLL: Additional Patients and Extended Follow-up from the Phase 1/2 BRUIN Study. Blood 140(Supp. 1):2316-2320, 2022.
19. Shah NN, Wang ML, Brown JR, Patel K, Woyach JA, Wierda WG, Ujjani CS, Eyre TA, Zinzani PL, Alencar AJ, Gastinne T, Ghia P, Lamanna N, Hoffmann M, Patel MR, Flinn IW, Gerson JN, Ma S, Coombs CC, Cheah CY, Lech-Marańda E, Fakhri B, Kim WS, Barve MA, Cohen JB, Jurczak W, Munir T, Thompson MC, Roeker LE, Bao K, Cangemi NA, Kherani JF, Walgren RA, Han H, Ruppert AS, Mato AR. Safety and Tolerability of Pirtobrutinib Monotherapy in Patients with B-Cell Malignancies Who Were Previously Intolerant to a Covalent BTK Inhibitor: Results from the Phase 1/2 BRUIN Study. Blood 140(Supp 1):4127-4132, 2022.
20. Byrd JC, Woyach JA, Furman RR, Martin P, O'Brien S, Brown JR, Stephens DM, Barrientos JC, Patten PEM, Munir T, Patel K, Butturini A, Borja M, Wang MH, Jain N, Wierda WG. Final Results of the Phase 1/2 Study of Acalabrutinib Monotherapy in Treatment-Naive Chronic Lymphocytic Leukemia with >6 Years of Follow-up. Blood 140(Supp 1):9865-9867, 2022.
21. Singh J, Rohena DD, Liu C, Slawin B, Ravikrishnan J, Jain N, Wierda WG, Zhang K, Niesman M, Woyach JA, Sampath D. MS-553, a Selective PKC-ß Inhibitor Inhibits BCR Signaling and Synergizes with Venetoclax for the Treatment of High Risk CLL. Blood 140(Supp 1):9857-9858, 2022.
22. Allan JN, Siddiqi T, Kipps TJ, Kuss BJ, Badoux XC, Barrientos JC, Tedeschi A, Opat S, Flinn IW, Barca EG, Jacobs R, Szafer-Glusman E, Zhou C, Szoke A, Wierda WG, Ghia P, Tam CS. Treatment Outcomes after Undetectable MRD with First-Line Ibrutinib (Ibr) Plus Venetoclax (Ven): Fixed Duration Treatment (Placebo) Versus Continued Ibr with up to 5 Years Median Follow-up in the CAPTIVATE Study. Blood 140(Supp 1):224-227, 2022.
23. Tam CS, Allan JN, Siddiqi T, Kipps TJ, Jacobs R, Opat S, Barr PM, Tedeschi A, Trentin L, Bannerji R, Jackson S, Kuss BJ, Moreno C, Szafer-Glusman E, Russell K, Zhou C, Ninomoto J, JP Dean, Wierda WG, Ghia P. Fixed-duration ibrutinib plus venetoclax for first-line treatment of CLL: primary analysis of the CAPTIVATE FD cohort. Blood 139(22):3278-3289, 2022.
24. Siddiqi T, Soumera JDi, Dorritie KA, Stephens DM, Riedell PA, Arnason J, Kipps TJ, Gillenwater HH, Gong L, Yang K, Ogasawara K, Thorpe J, Wierda WG. Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL. Blood 139(12):1794-1806, 2022.
25. Rohena DD, Slawin B, Ravikrishnan J, Liu C, Hu W, Zhang P, Thompson PA, Wierda WG, Jain N, Zheng G, Zhou D, Woyach JA, Sampath D. Targeting Venetoclax Resistant CLL Using a Protac-Based BCL-2/BCL-XL Degrader. Blood 140(Supp 1):497-498, 2022.
26. Vaca A, Sivina M, Kim E, Ferrajoli A, Wierda WG, Burger JA. Changes in the T Helper Cell Compartment during Treatment with the BTK Inhibitor Acalabrutinib. Blood 140(Supp 1):9855-9856, 2022.
27. Thompson PA, Keating MJ, Ferrajoli A, Jain N, Peterson CB, Garg N, Ayala A, Hernandez JA, Kadia TM, Bose P, Pemmaraju N, Short N, Wierda WG. Venetoclax Consolidation Achieves Durable Off-Treatment Remissions in Patients with High Risk CLL Who Have Been on Ibrutinib More Than a Year. Blood 140(Supp 1):238-240, 2022.
28. Kim E, Sivina M, Vaca A, Ferrajoli A, Jain N, Thompson PA, Wierda WG, Wodarz D, Chiorazzi N, Burger JA. High Cell Death Rates at Start of Ibrutinib Therapy Predict for Deeper Remissions in Patients with Chronic Lymphocytic Leukemia (CLL). Blood 140(Supp 1):4140-4141, 2022.
29. DiPippo AJ, McGhie A, Lee J, Thompson PA, Jain N, Wierda WG, Kantarjian H, Ferrajoli A. Tolerability of Acalabrutinib after Prior Ibrutinib Treatment in Patients with CLL: Experience of a Tertiary Cancer Care Center. Blood 140(Supp 1):4153-4155, 2022.
30. Desikan SP, Keating MJ, Ferrajoli A, Jain N, Ohanian M, Pemmaraju N, DiNardo CD, Konopleva M, Kadia TM, O'Brien S, Estrov ZE, Thomas DA, Burger JA, Thompson PA, Wierda WG. Early Treatment with Ofatumumab in Patients with High-Risk CLL. Blood 140(Supp n1):9876-9878, 2022.
31. Furman RR, Wierda WG, Schuh A, Patten PE, Chaves JM, Brown JR, Munir T, Martin P, Awan FT, Stephens DM, Ghia P, Barrientos JC, Patel K, Woyach JA, Butturini A, Borja M, Wang MH, O'Brien S, Byrd JC. Phase 1/2 Study of Acalabrutinib Monotherapy in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Results with >4 Years of Follow-up. Blood 140(Supp 1):9873-9875, 2022.
32. Nasnas P, Jabbour E, Short N, Sasaki K, Ravandi F, Jain N, Daver N, Pemmaraju N, Yilmaz M, Kadia TM, Garris R, Garcia-Manero G, DiNardo CD, Konopleva M, Wierda WG, Kwari M, Loiselle C, Milton A, Rivera J, Banks G, Kantarjian H. Frontline Combination of Hyper-CVAD with Ponatinib for Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia-6-Year Follow-up Results. Blood 140(Supp 1):3250-3252, 2022.
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83. Sasaki K, Kantarjian HM, Issa GC, Garcia-Manero G, Kadia TM, Wierda WG, Yilmaz M, DiNardo CD, Skinner J, Khouri R, Pemmaraju N, Nasnas P, Dellasala SE, Pierce SA, Cortes JE, Jabbour E. Impact of Molecular Response at Specific Timepoints in Patients with Newly Diagnosed Chronic Myeloid Leukemia Treated with Second Generation Tyrosine Kinase Inhibitors. Blood 136(Supplement 1):42-44, 2020.
84. Cherng HJ, Jammal N, Paul S, Wang X, Sasaki K, Thompson PA, Burger JA, Ferrajoli A, Estrov ZE, O'Brien SM, Keating MJ, Wierda WG, Jain N. Examination of Clinical and Molecular Characteristics and Treatment Patterns of Adolescent and Young Adult (AYA) Patients with Chronic Lymphocytic Leukemia. Blood 136(Supplement 1):5-6, 2020.
85. Jones J, George BS, Peterson CB, Ha TT, Burger JA, Jain N, Keating MJ, Wierda WG, Durand J-B, Ferrajoli A. Hypertension, Cardiovascular and Renal Complications Observed in Patients with Chronic Lymphocytic Leukemia Receiving Long-Term Therapy with Ibrutinib. Blood 136(Supplement 1):27-28, 2020.
86. Thompson PA, Ferrajoli A, Jain N, Wang Y, Peterson CB, Garg N, Wei C, Ayala A, Kadia TM, Bose P, Pemmaraju N, Short NJ, Keating MJ, Wierda WG. The Addition of Venetoclax to Ibrutinib Achieves a High Rate of Undetectable Minimal Residual Disease in Patients with High-Risk CLL. Blood 136(Supplement 1):28-29, 2020.
87. Seymour JF, Gribben JG, Davids MS, Mato A, Sharman JP, Cyr A, Bartkus C, Pena G, Boyer M, Sharmokh S, Rosenberg TS, Wierda WG. Assessment of Tumor Lysis Syndrome in Patients with Chronic Lymphocytic Leukemia Treated with Venetoclax in the Clinical Trial and Post-Marketing. Blood 136(Supplement 1):37-38, 2020.
88. Sivina M, Jain N, Kim E, Kadia TM, Estrov ZE, Ohanian M, Andreeff M, Thomas M, Thompson PA, Kantarjian HM, Keating MJ, O'Brien SM, Wierda WG, Ferrajoli A, Burger JA. Ibrutinib Induces Durable Remissions in Treatment-Naive CLL Patients with 17p Deletion/TP53 Mutations: Five Year Follow-up from a Phase 2 Study. Blood 136(Supplement 1):22-23, 2020.
89. Parry EM, Guieze R, Leshchiner I, Rosebrock D, Persaud B, Lemvigh CK, Tausch E, Davids MS, Bloehdorn J, Schneider C, Elagina L, Martinez AZ, Taylor-Weiner A, Jain N, Wierda WG, Rassenti LZ, Kipps TJ, Broseus J, Cymbalista F, Kay NE, Livak KJ, Li S, Huang T, Purroy N, Anandappa AJ, Fernandes SM, Utro F, Rhrissorrakrai K, Levovitz C, Danysh BP, Slowik K, Parikh SA, Brown JR, Parida L, Neuberg DS, Stilgenbauer S, Getz G, Wu CJ. Genetic Determinants and Evolutionary History of Richter's Syndrome. Blood 136(Supplement 1):47-48, 2020.
90. Sharman JP, Banerji V, Fogliatto LM, Herishanu Y, Munir T, Walewska R, Follows G, Karlsson K, Ghia P, Corbett G, Walker P, Egyed M, Jurczak W, Salles G, Janssens A, Cymbalista F, Wierda WG, Coutre S, Pagel JM, Skarbnik A, Kamdar M, Woyach J, Izumi R, Munugalavadla V, Patel P, MH Wang, , Wong S, Byrd JC. ELEVATE TN: Phase 3 Study of Acalabrutinib Combined with Obinutuzumab (O) or Alone Vs O Plus Chlorambucil (Clb) in Patients (Pts) with Treatment-Naive Chronic Lymphocytic Leukemia (CLL). Blood 134(Supplement 1):31, 2019.
91. Short NJ, Kantarjian HM, Ravandi F, Huang X, Jain N, Sasaki K, Khouri R , Daver NG, Pemmaraju N, Khoury JD, Jorgensen JL, , Alvarado Y, Konopleva MY, Garcia-Manero G, Kadia TM, Yilmaz ME, Borthakur GM, Burger JA, Kornblau SM, Wierda WG, DiNardo CD, Ferrajoli A, Jacob J, Rostykus M, Garris R, Ward M, Huang B, Encarnacion C, Loiselle C, O'Brien SM, Jabbour E. Updated Results of a Phase II Study of Reduced-Intensity Chemotherapy with Mini-Hyper-CVD in Combination with Inotuzumab Ozogamicin, with or without Blinatumomab, in Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia. Blood 134(Supplement 1):823, 2019.
92. William G. Wierda, MD PhD , Seung Tae Lee, MD PhD , Rong Chen, PhD , Daniella Zheleva, PhD , David Blake, PhD , Judy H Chiao, MD , William Plunkett, PhD. A Phase I Study Combining CDK2/9 Inhibitor CYC065 with Venetoclax, a BCL2 Inhibitor, to Treat Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL). Blood 134(Supplement 1):1761, 2019.
93. Koji Sasaki, MD , Hagop M. Kantarjian, MD , Elias Jabbour, MD , Farhad Ravandi, MD , Marina Y Konopleva, MD PhD , Gautam M. Borthakur, MD , <b>William G. Wierda, MD PhD</b> , Naval G. Daver, MD , Koichi Takahashi, MD , Kiran Naqvi, MDMPH , Courtney D. DiNardo, MDMSc , Guillermo Montalban Bravo, MD , Rashmi Kanagal-Shamanna, MD , Naveen Pemmaraju, MD , Ghayas C. Issa, MD , Preetesh Jain, MBBS,MDDM,PhD , Jeffrey Skinner, MHA , Mary B. Rios, RN , Sherry A. Pierce, BSN, BA , Kelly Soltysiak, PhD , Junya Sato , Guillermo Garcia-Manero, MD , Jorge E. Cortes, MD. The Impact of Treatment Recommendation By Leukemia Artificial Intelligence Program (LEAP) on Survival in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP). Blood 134(Supplement 1):1642, 2019.
94. Jeff P. Sharman, MD, Versha Banerji, MD, Laura Maria Fogliatto, MD PhD, Yair Herishanu, MD, Talha Munir, MD, Renata Walewska, George Follows, Karin Karlsson, MD, Paolo Ghia, MD PhD, Gillian Corbett, Patricia Walker, MBBS, Miklos Egyed, Wojciech Jurczak, MD PhD, Gilles Salles, MD PhD, Ann Janssens, Florence Cymbalista, MD PhD, William Wierda, MD,PhD, Steven Coutre, MD, John M. Pagel, MD PhD DSc, Alan Skarbnik, MD, Manali Kamdar, MD, Jennifer Woyach, MD, Raquel Izumi, PhD, Veerendra Munugalavadla, PhD, Priti Patel, MD, Min Hui Wang, PhD, Sofia Wong, John C. Byrd, MD. Expansion of T Helper Cell Subsets in Chronic Lymphocytic Leukemia Cell Co-Cultures with Nurselike Cells. Blood 134(Supplement 1):1746, 2019.
95. Michael Y. Choi, MD , Emanuela M. Ghia, PhD , Tanya Siddiqi, MD , William G. Wierda, MD PhD , Hun Ju Lee , Jacqueline C. Barrientos, MD MS , Nicole Lamanna, MD , Alec Goldenberg , Dimitrios Tzachanis, MD PhD , Erin G. Reid, MD MS , Elizabeth K Weihe, MD , Laura Z. Rassenti, PhD , Iris Isufi, MD , Stewart Bieler, BA , Xen Ianopulos, MD PhD , James B. Breitmeyer, MD PhD , Catriona Jamieson, MD PhD , Thomas J. Kipps, MD PhD. Cirmtuzumab, a ROR1 Targeted Mab, Reverses Cancer Stemness, and Its Combination with Ibrutinib Is Safe and Effective: Planned Analysis of the Cirll Phase 1/2 Trial for CLL and MCL. Blood 134(Supplement 1):1755, 2019.
96. Anthony R. Mato, MDMSCE , Kavita Sail, PhD , Maryam Sarraf Yazdy, MD , Brian T. Hill, MD , Mazyar Shadman, MD MPH , Beenish S Manzoor, PhD , Hande H. Tuncer, MD , John N. Allan, MD , Chaitra S. Ujjani, MD , Simon Sharmokh, MPH, PharmD , Daniel Dingfeng Jiang, MD PhD , German Pena, MD , Thomas Marshall, PharmD, MS , Jacqueline Nielsen, PhD , Paul M. Barr, MD , Jennifer R. Brown, MD PhD , Anna Schuh, PhD , Toby A. Eyre, MD , William G. Wierda, MD PhD , Alan Skarbnik, MD , Lindsey E. Roeker, MD , Rajat Bannerji, MD PhD , James M. Pauff, MD PhD , Stephen J. Schuster, MD , George A Follows, MD PhD , Bruce D. Cheson, MD , Barbara F. Eichhorst, MD , Danielle M. Brander, MD , Irina Pivneva, PhD , Nicole Lamanna, MD. Treatment Sequences and Outcomes of Patients with CLL Treated with Venetoclax and Other Novel Agents Post Introduction of Novel Therapies. Blood 134(Supplement 1):1756, 2019.
97. Nitin Jain, MD , Michael J Keating, MBBS , Philip A. Thompson, MBBS , Alessandra Ferrajoli, MD , Jan A. Burger, MD PhD , Gautam M. Borthakur, MD , Koichi Takahashi, MD , Zeev E. Estrov, MD , Nathan H. Fowler, MD , Tapan M. Kadia, MD , Marina Y Konopleva, MD PhD , Yesid Alvarado, MD , Musa Yilmaz, MD , Courtney D. DiNardo, MDMSc , Prithviraj Bose, MD , Maro Ohanian, DO , Naveen Pemmaraju, MD , Elias Jabbour, MD , Koji Sasaki, MD , Rashmi Kanagal-Shamanna, MD , Keyur Patel, MD PhD , Jeffrey L. Jorgensen, MD PhD , Sa A Wang, MD , Naveen Garg, MD , Xuemei Wang, MS , Katrina Sondermann, BA , Nichole Cruz, RN , Chongjuan Wei, PhD , Ana Ayala, RN , William Plunkett, PhD , Hagop M. Kantarjian, MD , Varsha Gandhi, PhD , William G. Wierda, MD PhD. Combined Ibrutinib and Venetoclax for First-Line Treatment for Patients with Chronic Lymphocytic Leukemia (CLL). Blood 134(Supplement 1):34, 2019.
98. Tanya Siddiqi, MD , Jacob D. Soumerai, MD , Kathleen A. Dorritie, MD , Deborah M. Stephens, DO , Peter A. Riedell, MD , Jon E. Arnason, MD , Thomas J. Kipps, MD PhD , Heidi H. Gillenwater, MD , Lucy Gong, PharmD , Jason A. Dubovsky, PhD , Julie Rytlewski, PhD , Lin Yang , William G. Wierda, MD PhD. Rapid Undetectable MRD (uMRD) Responses in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Treated with Lisocabtagene Maraleucel (liso-cel), a CD19-Directed CAR T Cell Product: Updated Results from Transcend CLL 004, a Phase 1/2 Study Including Patients with High-Risk Disease Previously Treated with Ibrutinib. Blood 134(Supplement 1):503, 2019.
99. Vivian M. Liu, MD , Romain Guièze, MD , Daniel Rosebrock , Alexis A Jourdain, PhD , María Hernández-Sánchez, PhD , Aina Zurita Martinez , Elisa Ten Hacken, PhD , Philip A. Thompson, MBBS , Julian Bryan Iorgulescu, MD PhD , Shuqiang Li, PhD , Matthew S. Davids, MD , Jennifer R. Brown, MD PhD , Ana Lako , Zoe B. Ciantra , Matthew A. Lawlor , William G. Wierda, MD PhD , Anthony G. Letai, MD PhD , Donna S Neuberg, ScD , Christopher J. Ott, PhD , Ignaty Leshchiner, PhD , Vamsi Mootha, MD , Gad Getz, PhD , Catherine J. Wu, MD. MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers. Blood 134(Supplement 1), 2019.
100. Jeff P. Sharman, MD, Versha Banerji, MD, Laura Maria Fogliatto, MD PhD, Yair Herishanu, MD, Talha Munir, MD, Renata Walewska, George Follows, Karin Karlsson, MD, Paolo Ghia, MD PhD, Gillian Corbett, Patricia Walker, MBBS, Miklos Egyed, Wojciech Jurczak, MD PhD, Gilles Salles, MD PhD, Ann Janssens, Florence Cymbalista, MD PhD, William Wierda, MD,PhD, Steven Coutre, MD, John M. Pagel, MD PhD DSc, Alan Skarbnik, MD, Manali Kamdar, MD, Jennifer Woyach, MD, Raquel Izumi, PhD, Veerendra Munugalavadla, PhD, Priti Patel, MD, Min Hui Wang, PhD, Sofia Wong, John C. Byrd, MD. Prognostic Factors for Progression in Patients (pts) with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) in Complete Molecular Response (CMR) within 3 Months of Therapy with Tyrosine Kinase Inhibitors (TKIs). Blood 134(Supplement 1):1296, 2019.
101. Musa Yilmaz, MD , Hagop M. Kantarjian, MD , Xuemei Wang, MS , Joseph D. Khoury, MD , Farhad Ravandi, MD , Jeffrey L. Jorgensen, MD PhD , Nicholas J. Short, MD , Sanam Loghavi, MD , Jorge E. Cortes, MD , Guillermo Garcia-Manero, MD , Tapan M. Kadia, MD , Koji Sasaki, MD , Marina Y Konopleva, MD PhD , Koichi Takahashi, MD , William G. Wierda, MD PhD , Nitin Jain, MD , Srdan Verstovsek, MD PhD , Zeev E. Estrov, MD , Prithviraj Bose, MD , Sherry A. Pierce, BSN, BA , Rebecca Garris, MSc , Susan M. O'Brien, MD , Elias Jabbour, MD. The Early Achievement of Measurable Residual Disease Negativity in the Treatment of Adults with Philadelphia-Negative B-Cell Acute Lymphoblastic Leukemia Is a Strong Predictor for Survival. Blood 134(Supplement 1):1297, 2019.
102. Constantine S. Tam, MBBS, MD , Tanya Siddiqi, MD , John N. Allan, MD , Thomas J. Kipps, MD PhD , Ian W. Flinn, MD PhD , Bryone J. Kuss, MBBS, PhD FRACP, FRCPA , Stephen Opat , Paul M. Barr, MD , Alessandra Tedeschi, MD , Ryan Jacobs, MD , Xavier C. Badoux, MBBS, FRACP, FRCPA , Paolo Ghia, MD PhD , Juthamas Sukbuntherng, PhD , Ahmed Hamed Salem, PhD FCP , Kristin Russell, BS , Karl Eckert, BA , Cathy Zhou, MS , Joi Ninomoto, PharmD , Danelle F. James, MD MAS , William G. Wierda, MD PhD. Ibrutinib (Ibr) Plus Venetoclax (Ven) for First-Line Treatment of Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL): Results from the MRD Cohort of the Phase 2 CAPTIVATE Study. Blood 134(Supplement 1):35, 2019.
103. Guillaume Richard-Carpentier, MD , Hagop M. Kantarjian, MD , Nicholas J. Short, MD , Farhad Ravandi, MD , Alessandra Ferrajoli, MD , Heather M Schroeder , Guillermo Garcia-Manero, MD , Guillermo Montalban Bravo, MD , Jorge E. Cortes, MD , Monica Kwari, BSN , Christopher Loiselle, BS , Rebecca Garris, MSc , Nicole Volter, RDC , Nitin Jain, MD , Marina Y Konopleva, MD PhD , Koichi Takahashi, MD , Koji Sasaki, MD , William G. Wierda, MD PhD , Elias Jabbour, MD. Combined Ibrutinib and Venetoclax for First-Line Treatment for Patients with Chronic Lymphocytic Leukemia (CLL). Blood 134(Supplement 1):3807, 2019.
104. Patel K, Michot JM, Chanan-Khan AA, Salles GA, Cartron G, Peyrade F, Bouabdallah R , Reid EG, Thomas SK, Wierda WG, Liebowitz D, Pagel JM, Ribrag V, Saville MW, Johnson CM, Ly T, Phillips TJ. ELEVATE TN: Phase 3 Study of Acalabrutinib Combined with Obinutuzumab (O) or Alone Vs O Plus Chlorambucil (Clb) in Patients (Pts) with Treatment-Naive Chronic Lymphocytic Leukemia (CLL). Blood 134(Supplement 1):4079, 2019.
105. Tambaro F, Ragoonanan D, Khazal D, Petropoulos D, Tewari P, Kebriaei P, Wierda WG, Kohorst MA, Mahadeo KM. ELEVATE TN: Phase 3 Study of Acalabrutinib Combined with Obinutuzumab (O) or Alone Vs O Plus Chlorambucil (Clb) in Patients (Pts) with Treatment-Naive Chronic Lymphocytic Leukemia (CLL). Blood 134(Supplement 1):4495, 2019.
106. Furman RR, Wierda WG, Schuh A, Devereux S, Chaves JM, Brown JR, Hillmen P, Martin P, Awan FT, Stephens DM, Ghia P, Barrientos JC, Pagel JM, Woyach J, Burke K, Covey T , Gulrajani M, Hamdy A, Izumi R, Frigault MM, Patel P, Rothbaum W, Wang MH, O'Brien SM, Byrd JC. ELEVATE TN: Phase 3 Study of Acalabrutinib Combined with Obinutuzumab (O) or Alone Vs O Plus Chlorambucil (Clb) in Patients (Pts) with Treatment-Naive Chronic Lymphocytic Leukemia (CLL). Blood 134(Supplement 1):3039, 2019.
107. John N. Allan, MD , Krish Patel, MD , Anthony R. Mato, MDMSCE , William G. Wierda, MD PhD , Javier Pinilla Ibarz, MD PhD , Michael Y. Choi, MD , Susan M. O'Brien, MD , Jeff P. Sharman, MD , Mazyar Shadman, MD , Douglas E Gladstone, MD , Matthew S. Davids, MD , John M. Pagel, MD PhD DSc , Renee Ward, MD PhD , Gary Acton, MD , Pietro Taverna, PhD , Judith A. Fox, PhD , Richard R. Furman, MD , Jennifer R. Brown, MD PhD. Ongoing Results of a Phase 1B/2 Dose-Escalation and Cohort-Expansion Study of the Selective, Noncovalent, Reversible Bruton'S Tyrosine Kinase Inhibitor, Vecabrutinib, in B-Cell Malignancies. Blood 134(Supplement 1):3041, 2019.
108. Abhishek Maiti, MBBS , Hagop M. Kantarjian, MD , Guillermo Garcia-Manero, MD , Marina Y Konopleva, MD PhD , Srdan Verstovsek, MD PhD , Michael Andreeff, MD PhD , Gautam M. Borthakur, MD , Tapan M. Kadia, MD , Naval G. Daver, MD , Naveen Pemmaraju, MD , Courtney D. DiNardo, MDMSc , Sherry A. Pierce, BSN, BA , Lian-Chun Xiao , Xuelin Huang, PhD , William G. Wierda, MD PhD , Steven M. Kornblau, MD , Farhad Ravandi, MD , Jorge E. Cortes, MD. Determinants of Outcomes of FLT3mut Acute Myeloid Leukemia with First Salvage Therapy. Blood 134(Supplement 1):2641, 2019.
109. Vazquez MR , Kantarjian HM, Borthakur GM, O'Brien S, Verstovsek S, Ravandi F, Ferrajoli A, Cortes JE, Kadia TM, |BWierda WG||B, Garcia-Manero G, Dellasala SE, Kehr KA, Pierce SA, Rios MB, Jabbour E. A 20-Year Review of Imatinib in Chronic Phase Chronic Myeloid Leukemia Patients after Failure with Interferon Therapy. Blood 134(Supplement 1):2927, 2019.
110. Uri Rozovski, MD , David M. Harris, PhD , Ping Li, PhD , Zhiming Liu, BS , Taghi Manshouri, PhD , Ivo Veletic, MD , Preetesh Jain, MBBS,MDDM,PhD , Alessandra Ferrajoli, MD , Jan A. Burger, MD PhD , Prithviraj Bose, MD , Philip A. Thompson, MBBS , Nitin Jain, MD , Srdan Verstovsek, MD PhD , William G. Wierda, MD PhD , Michael J Keating, MBBS , Zeev E. Estrov, MD. Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells. Blood 134(Supplement 1):3018, 2019.
111. Mazyar Shadman, MD MPH , Kavita Sail, PhD , Beenish S Manzoor, PhD , Maryam Sarraf Yazdy, MD , Brian T. Hill, MD , Hande H. Tuncer, MD , John N. Allan, MD , Chaitra S. Ujjani, MD , Nnadozie Emechebe, MPH , Rajesh Kamalakar, MS , Simon Sharmokh, MPH, PharmD , Daniel Dingfeng Jiang, MD PhD , German Pena, MD , Thomas Marshall, PharmD, MS , Jacqueline Nielsen, PhD , Paul M. Barr, MD , Jennifer R. Brown, MD PhD , Anna Schuh, PhD , Toby A. Eyre, MD , Nicole Lamanna, MD , William G. Wierda, MD PhD , Alan Skarbnik, MD , Lindsey E. Roeker, MD , Rajat Bannerji, MD PhD , James M. Pauff, MD PhD , Stephen J. Schuster, MD , George A Follows, MD PhD , Bruce D. Cheson, MD , Barbara F. Eichhorst, MD , Danielle M. Brander, MD , Irina Pivneva, PhD , Annie Guerin, MSc , Anthony R. Mato, MDMSCE. Treatment Discontinuation Patterns for Patients with CLL in the Real-World Settings: Results from a Multi-Center Study. Blood 134(Supplement 1):3048, 2019.
112. Uri Rozovski, MD , David M. Harris, PhD , Ping Li, PhD , Zhiming Liu, BS , Taghi Manshouri, PhD , Ivo Veletic, MD , Preetesh Jain, MBBS,MDDM,PhD , Alessandra Ferrajoli, MD , Jan A. Burger, MD PhD , Prithviraj Bose, MD , Philip A. Thompson, MBBS , Nitin Jain, MD , Srdan Verstovsek, MD PhD , William G. Wierda, MD PhD , Michael J Keating, MBBS , Zeev E. Estrov, MD. Constitutively Activated STAT3 Induces the Production of PTX3 That Contributes to the Induction of Bone Marrow Reticulin Fibrosis in Patient with CLL. Blood 134(Supplement 1):3024, 2019.
113. Ekaterina Kim, MS , Hongying Zhang, MD PhD , Mariela Sivina , Alicia Vaca, PhD , Philip A. Thompson, MBBS , Nitin Jain, MD , Alessandra Ferrajoli, MD , Zeev E. Estrov, MD , Michael J Keating, MBBS , William G. Wierda, MD PhD , William G Rice, PhD , Michael Andreeff, MD PhD , Jan A. Burger, MD PhD. CG-806, a First-in-Class Pan-FLT3/Pan-BTK Inhibitor, Exhibits Broad Signaling Inhibition in Chronic Lymphocytic Leukemia Cells. Blood 134(Supplement 1):3051, 2019.
114. Nicholas J. Short, MD , Hagop M. Kantarjian, MD , Farhad Ravandi, MD , Xuelin Huang, PhD , Naval G. Daver, MD , Courtney D. DiNardo, MD MSc , Marina Y Konopleva, MD PhD , Naveen Pemmaraju, MD , William G. Wierda, MD PhD , Guillermo Garcia-Manero, MD , Koji Sasaki, MD , Jorge E. Cortes, MD , Rebecca Garris, MSc , Marygrace Ward, RDC , Binru Huang, RDC , Corabelle Encarnacion, RDC , Christopher Loiselle, BS , Joseph D. Khoury, MD , Jeffrey L. Jorgensen, MD PhD , Nitin Jain, MD , Joie Alvarez, RN , Nicole Tippett, RN , Susan M. O'Brien, MD , Elias Jabbour, MD. Long-Term Safety and Efficacy of Hyper-CVAD Plus Ponatinib As Frontline Therapy for Adults with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Blood 134(Supplement 1):283, 2019.
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119. Mariela Sivina , Gordon Duncan, MSc , Takashi Sakamoto, MD PhD , Ekaterina Kim, MS , Alicia Vaca, PhD , Elena Maria Hartmann, MD , Michael J Keating, MBBS , Alessandra Ferrajoli, MD , William G. Wierda, MD PhD , Tak Mak, PhD DSc , Andreas Rosenwald, MD , Jan A. Burger, MD PhD. Ibrutinib Therapy Downregulates Toso, the Fcr for IgM, Expression in CLL Patients. Blood, 2019.
120. Giacopelli B , Zhao Q, Ruppert A , Agyeman A , Weigel C, Wu YZ, Gerber M , Rabe KG, Larson MC , Lu J , Blachly JS , Rogers KA, Wierda, WG, Brown JR, Rai KR, Keating M , Rassenti LZ , Kipps TJ, Zenz T , Shanafelt TD , Kay NE , Abruzzo LV , Coombes KR , Woyach JA , Byrd JC , Oakes CC. Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia. Blood 134(8):688-698, 2019.
121. Wierda WG, Kipps TJ, Durig J, Griskevicius L, Stilgenbauer S, Mayer J, Smolej L, Hess G, Griniute R, Hernandez-Ilizaliturri FJ, Padmanabhan S, Strange M, Nielsen TG, Russell CA.. Ofatumumab Combined with Fludarabine and Cyclophosphamide (O-FC) Shows High Activity in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL): Results From a Randomized, Multicenter, International, Two-Dose, Parallel Group, Phase II Trial. Blood 114(22):90, 2009.

Book Chapters

1. Wierda WG, Keating MJ, O'Brien S.. Chronic Lymphocytic Leukemia. In: Cancer: Principles and Practice of Oncology. 8th. Lipppincott Williams & Wilkins: Philadelphia, 2278-2292, 2009.
2. Cortes JE, Kantarjian H., Wierda W. Chronic Leukemias. In: Conn's Current Therapy. W. B. Saunders Company Publications: Pennsylvania, 456-463, 2009.
3. Wierda WG. Gene Therapeutic Approaches for Chronic Lymphocytic Leukemia. In: Unknown, 201-215, 2008.
4. Wierda, WG. Gene Therapy, Vaccines and Immune Modulation. In: Chronic Lymphocytic Leukemia. Informa Healthcare, 2008.