Xiaorong Ronald Zhu, PhD, FAAPM
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Center Physics Director, Proton Therapy Center, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Proton therapy physics, tumor and normal tissue responses assessed by various imaging modality
Clinical Interests
Proton therapy physics
Education & Training
Degree-Granting Education
| 1989 | University of Utah, Salt Lake City, Utah, US, Chemical Physics, Ph.D |
| 1984 | University of Utah, Salt Lake City, Utah, US, Physics, M.S |
| 1982 | Nanjing University, Nanjing, CN, Physics, BS |
Postgraduate Training
| 1994-1996 | Medical Physics Residency, Radiation Oncology Physics, Washington University School of Medicine, St. Louis, Missouri |
| 1993-1994 | Postdoctoral Fellowship, Radiation Oncology Physics, Washington University School of Medicine, St. Louis, Missouri |
| 1990-1992 | Postdoctoral Fellowship, Chemical Physics, University of Utah, Salt Lake City, Utah |
Licenses & Certifications
| 2003 | Medical Physicist License awarded by the Texas Medical Board |
| 1997 | American Board of Medical Physics (ABMP) |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2003 - 2008
Assistant Professor, Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, 2000 - 2003
Assistant Professor, Department of Radiation Oncology, Albany Medical College, Albany, NY, 1996 - 1996
Administrative Appointments/Responsibilities
Center Physics Director, Proton Therapy Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - Present
Deputy Chief of Clinical Physics, Proton, Department of Radiation Physics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2015
Director for Radiation Oncology Physics Residency Program, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005 - 2015
Co-Director for Radiation Oncology Physics Residency Program, Department of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX, 2004 - 2005
Co-Director of IMRT Short Course, Department of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX, 2004 - 2006
Acting Chief of Medical Physics, Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, 2002 - 2003
Other Professional Positions
Senior Medical Physicist, Medical College of Wisconsin, Milwaukee, WI, 1998 - 2000
Senior Medical Physicist, St. Luke Medical Center, Milwaukee, WI, 1996 - 1998
Extramural Institutional Committee Activities
Vice Chair, Clinical Education for Non-Physician Committee (CENPC), The University of Texas MD Anderson Cancer Center, 2010 - 2011
Chair, Non-Tenure Track Progress Review Committee for Dr. Eric Chang, The University of Texas MD Anderson Cancer Center, 2009 - 2009
Member, Clinical Education for Non-Physician Committee (CENPC), The University of Texas MD Anderson Cancer Center, 2005 - 2015
Member, Educational Council - Dept. Radiation Physics, The University of Texas MD Anderson Cancer Center, 2004 - 2015
Member, Short Course Committee - Dept. Radiation Physics, The University of Texas MD Anderson Cancer Center, 2004 - 2006
Editorial Activities
Associate Editor, International Journal of Particle Therapy, 2022 - Present
Section Editor, Journal of Applied Clinical Medical Physics, 2007 - 2012
Honors & Awards
| 2010 | Fellow, American Association of Physicists in Medicine |
| 2007 | Outstanding Achievement Award, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center |
| 1996 | RSNA Roentgen Resident/Fellow Research Award |
| 1982 | CUSPEA Fellow |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2016. Current Status of Spot Scanning Proton Therapy Physics. Conference. M. D. Anderson Cancer Center. Houston, TX, US.
- 2011. Proton Beam Therapy - Patient Specific Quality Assurance for Intensity Modulated Proton Therapy. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2011. Spot Scanning Proton Therapy: Treatment Planning and Patient Specific Quality Assurance. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2010. Proton therapy treatment planning. Conference. Health Physics Society Texas. Houston, TX, US.
- 2009. Commissioning Scanning Pencil Beam for Proton Therapy - M. D. Anderson Experience. Conference. UT M. D. Anderson Cancer Center. Houston, TX, US.
- 2007. Proton beam calibration at PTCH. Conference. The University of Texas M. D. Anderson. Houston, TX, US.
- 2005. Performance evaluation of Varian cone beam CT on Trilogy. Conference. UT M. D. Anderson Cancer Center. Houston, TX, US.
- 2005. Dosimetric impact of anatomic variations for head and neck cancer patients undergoing IMRT treatment. Conference. UT M. D. Anderson Cancer Center. Houston, TX, US.
Regional Presentations
- 2010. IMPT: Challenges and Opportunities. Conference. The University of Texas MD Anderson Cancer Center, TX, US.
- 2008. Proton Scanning Beam Treatment Planning for Prostate Patients. Conference. UT M. D. Anderson Cancer Center, US.
- 2008. In-Room Imaging - The Nuts and Bolts of Daily Image Guided Proton Therapy at PTCH. Conference. The University of Texas M.D. Anderson, TX, US.
- 2006. Imaging guided radiation therapy – The new radiation fad. Conference. UT M. D. Anderson Cancer Center, US.
- 2005. OBI and CBCT. Invited. UT M. D. Anderson Cancer Center, US.
- 2005. Measurements of in-air output ratio for a linear accelerator with and without flattening filter. Conference. UT M. D. Anderson Cancer Center, US.
- 2004. Head and Neck Proton Planning. Invited. UT M. D. Anderson Cancer Center, US.
- 2004. IMRT planning of mesothelioma, Department of Radiation Physics. Conference. UT M. D. Anderson Cancer Center, US.
- 2004. Status of Acceptance test and commissioning of linear accelerator 2109. Invited. UT M. D. Anderson Cancer Center, US.
- 2003. Electronic portal imaging devices, Department of Radiation Oncology. Conference. Medical College of Wisconsin, US.
- 2002. Wisconsin’s new rules for radiation therapy machines: HFS157 – radiation protection. Invited. Medical College of Wisconsin, US.
- 2002. IMRT at MCW: Current status and future direction. Invited. Medical College of Wisconsin, US.
- 2001. Technical details CORVUS/Siemens based step and shot IMRT. Invited. Technical details CORVUS/Siemens based step and shot IMRT. Milwaukee, WI, US.
- 2001. IMRT above the clavicle. Invited. Medical College of Wisconsin, US.
- 2000. Commission a virtual wedge model for a 3D treatment planning system. Invited. Medical College of Wisconsin, US.
- 2000. IMRT: Treatment process and quality assurance. Invited. IMRT: Treatment process and quality assurance. Milwaukee, WI, US.
- 1999. Dosimetric evaluation of virtual wedge. Invited. Medical College of Wisconsin, US.
- 1998. Dosimetry and treatment planning of prostate implants with iodine-125 seeds. Invited. Medical College of Wisconsin, US.
- 1994. A convolution adapted ratio-TAR algorithm for 3D treatment planning. Conference. Mallinckrodt Institute of Radiology Washington University. St. Louis, MO, US.
National Presentations
- 2016. Spot Scanning Beam Proton Therapy: Physical Basis. Invited. The 4th Samsung Comprehensive Cancer Center Symposium. Seoul.
- 2016. Personalized Motion Management Strategies for Pencil Beam Scanning Proton Therapy. Invited. 2016 Annual Meeting - AAPM. Washington DC, US.
- 2015. Robustness Considerations of Head & Neck Proton Therapy – M. D. Anderson Experiences. Invited. Seminar Series on Advanced Clinical Particle Therapy The Emerging Roles of Proton Therapy in Head & Neck Tumors. Carefree, AZ, US.
- 2015. Treatment planning for passive scattering proton therapy. Invited. AAPM 2015 Summer School - Proton Therapy: Physical Principles and Practice. Colorado Springs, CO, US.
- 2015. Field Shaping: Scanning Beam. Invited. AAPM 2015 Summer School - Proton Therapy: Physical Principles and Practice. Colorado Springs, CO, US.
- 2014. Spot Scanning Proton Therapy of Head & Neck. Invited. PTCOG NA. Houston, TX, US.
- 2014. Dose Calculation Algorithms and Commissioning. Invited. Symposium, "The Status of Intensity Modulated Proton and Ion Therapy". Austin, TX, US.
- 2013. Introduction of Proton Therapy Physics. Invited. Workshop - Clinical Physics and Treatment Planning. Houston, TX, US.
- 2012. Spot Scanning Proton Therapy Treatment Planning - AAPM Therapy Education Course, Proton Treatment Planning Issues. Invited. 2012 AAPM Annual Meeting. Charlotte, NC, US.
- 2012. Spot Scanning Proton Therapy – MDACC Experience, Panel Discussion Particle Beam Scanning - The developing frontier in particle therapy. Invited. Particle Therapy Co-Operative Group PTCOG 51. Seoul.
- 2012. Towards an Efficient and Effective Patient Specific QA Program for IMPT. Conference. Particle Therapy Co-Operative Group PTCOG 51. Seoul,.
- 2012. IMPT MDACC Experience (Spot Scanning). Conference. Clinical Proton Therapy Physics with Emphasis on Spot Scanning. Houston, TX, US.
- 2012. Overview of Clinical Proton Physics at MDACC. Conference. Clinical Proton Therapy Physics with Emphasis on Spot Scanning. Houston, TX, US.
- 2011. Spot Scanning proton therapy: single field simultaneous integrated boost. Conference. Particle Therapy Co-Operative Group PTCOG 50. Philadelphia, PA, US.
- 2011. Facility Start-up:Training and Operational. Invited. Particle Therapy Co-Operative Group PTCOG 50. Philadelphia, PA, US.
- 2011. Passive Scattering Proton Therapy Treatment Planning - Lung. Invited. Particle Therapy Co-Operative Group PTCOG 50. Philadelphia, PA, US.
- 2008. Patient immobilization and position verification strategies. Invited. Particle Therapy Co-Operative Group PTCOG 47 Meeting. Jacksonville, FL, US.
- 2007. The Effect of CT Number Uncertainty on Proton Range Uncertainty. Invited. 15th Annual Radiation Workshop at Round Top. Round Top, TX, US.
- 2006. Implementation of cone beam CT in the clinic. Invited. RadOnc 2006. Houston, TX, US.
- 2002. Dosimetric verification FOCUS IMRT for static MLC on Siemens Linear Accelerators. Conference. Computerized Medical System User Meeting. St. Louis, MO, US.
International Presentations
- 2019. Physical Basis of Proton Therapy. Invited. New Challenges in Medical Physics. Coimbra, PT.
- 2019. Clinical Commissioning of Proton Therapy. Invited. The 3rd Hefei International Forum on Heavy Ion Radiotherapy. Hefei, CN.
- 2017. Moving to Precision Proton Therapy for Lung Cancer - Physics Consideration. Invited. The 3rd Hefei International Forum for Radiological Medical Physics (HIFRMP). Hefei, CN.
- 2017. Clinical Implementation of Pencil Beam Scanning (PBS) Proton Therapy. Invited. American Association of Physicists in Medicine. Denver, US.
- 2017. Consensus guidelines for implementing pencil beam scanning proton therapy for thoracic malignancies on behalf of PTCOG thoracic subcommittee. Conference. PTCOG 56, 2017. Yokohama, JP.
- 2016. Training of Medical Physicists for Proton Therapy. Invited. The 13th National Congress of Radiation Oncology and CSTRO-SANTRO New Techology and Their Application in Radiation Oncology XKMed Proton and Heavy Ion Therapy Satellite Conference. Chengdu, CN.
- 2016. Proton Therapy Clinical Trials at MD Anderson Cancer Center. Invited. The 2nd Hefei International Forum for Radiological Medical Physics (HIFRMP). Hefei, CN.
- 2016. Proton Therapy Physics - Challenges and Opportunities. Invited. The 2nd Hefei International Forum for Radiological Medical Physics (HIFRMP). Hefei, CN.
- 2016. Proton Therapy Treatment Planning. Invited. The 2nd Hefei International Forum for Radiological Medical Physics (HIFRMP). Hefei, CN.
- 2014. Abstract Review Committee. Conference. PTCOG 53. Shanghai, CN.
- 2013. Scanning Beam Proton Therapy Treatment Planning: Current Status and Challenges. Invited. The 3rd International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique. Sapporo, JP.
- 2012. Current Status of Beam Scanning and Dealing with Organ Motion. Invited. 22nd International Conference on the Application of Accelerators in Research and Industry. Fort Worth, US.
- 2001. MLC Based Step and Shot IMRT: Commissioning and Quality Assurance. Invited. American Association of Medical Physicists, North Central Chapter Annual Meeting. Milwaukee, US.
- 2000. Commission a Virtual Wedge model for a 3D treatment planning system. Invited. 2nd Beijing International Congress of Medical Physics. Beijing, CN.
- 1993. A pencil-beam convolution algorithm for 3D treatment planning, American Association of Medical Physicists. Conference. Missouri River Chapter Annual Meeting. St. Louis, US.
Formal Peers
- 2018. Spot Scanning Proton Therapy Physics at MDACC. Visiting. Atlanta, GA, US.
- 2017. Spot Scanning Proton Therapy Physics at MDACC. Visiting. Cleveland, OH, US.
- 2016. Proton Therapy Physics at MD Anderson Cancer Center. Visiting. Phoenix, AZ, US.
- 2016. Spot Scanning Beam Proton Therapy Physics at MDACC. Visiting. Baltimore, MD, US.
- 2016. Spot Scanning Beam Proton Therapy Physics at MDACC. Visiting. Rochester, MN, US.
- 2016. Current Status of Proton Therapy Physics at MDACC. Visiting. Shanghai, CN.
- 2016. Current Status of Proton Therapy Physics at MDACC. Visiting. Wuhan, Wupei, CN.
- 2016. Toward Autoplan for Proton Therapy Treatment planning. Visiting. Tianjin, CN.
- 2016. Current Status of Proton Therapy at M. D. Anderson Cancer Center and Future Directions. Visiting. Shanghai, CN.
- 2013. Spot Scanning Proton Therapy at MD Anderson - a clinical physicist’s perspective. Visiting. San Diego, CA, US.
- 2013. Quality Assurance for Spot Scanning Proton Therapy - System and Patient Specific. Visiting. Boston, MA, US.
- 2013. Spot Scanning Proton Therapy at M. D. Anderson - a clinical physicist’s perspective. Visiting. Jacksonville, FL, US.
- 2013. Spot Scanning Proton Therapy Commissioning & Patient QA. Visiting. Jacksonville, FL, US.
- 2012. Proton beam therapy at M. D. Anderson - a clinical physicist's perspective. Visiting. Durham, NC, US.
- 2012. Should PTV be used in proton therapy planning? - How proton and photon plans should be compared with respect to coverage?. Visiting. Philadelphia, PA, US.
- 2012. Spot scanning proton therapy: Physics and clinical commissioning. Visiting. Durham, NC, US.
- 2012. Proton Scanning Beam Commissioning. Visiting. Seoul.
- 2011. Introduction of Proton Therapy Center at The University of Texas MD Anderson Cancer Center. Visiting. Shanghai, CN.
- 2011. Introduction of Spot Scanning Proton Therapy at The University of Texas MD Anderson Cancer Center. Visiting. Shanghai, CN.
- 2010. Synchrotron Based Proton Therapy at The University of Texas MD Anderson Cancer Center. Visiting. Shanghai, CN.
- 2009. Proton Therapy Treatment Planning. Visiting. Philadelphia, PA, US.
- 2009. Commissioning Scanning Pencil Beam for Proton Therapy - M. D. Anderson Experience. Visiting. Philadelphia, PA, US.
Grant & Contract Support
| Date: | 2024 - 2029 |
| Title: | High-Precision Proton Therapy for Liver Cancer: Developing an End-to-end Strategy with Real-time Marker-less Liver Tumor Localization and On-the-fly Plan Delivery Adaptation (R01) |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA280135-01A1 |
| Date: | 2023 - 2025 |
| Title: | Investigating the Effect of FLASH-Radiotherapy on Tumor and Normal Tissue (R21) |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R21CA273845-01A1 |
| Date: | 2023 - 2023 |
| Title: | Rusalatide Acetate (TP508) Mitigation of Genotoxic Radiation Damage in Human Lens Epithelial Cells |
| Funding Source: | Affirmed Pharma, Inc |
| Role: | Co-I |
| Date: | 2019 - 2023 |
| Title: | Novel On-line PET Based Intra-Beam Range Verification and Delivery Optimization for Improved Particle Radiation Therapy (R01) |
| Funding Source: | NIH/NCRR |
| Role: | Co-I |
| Date: | 2017 - 2019 |
| Title: | Improving Quality of Life in Head and Neck Cancer Patients with Proton Therapy |
| Funding Source: | Gateway for Cancer Research |
| Role: | Co-I |
| Date: | 2014 - 2016 |
| Title: | Road to PET Image-Based On-Line Proton Beam Range Measurement (R21) |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1-R21-CA187717-01 |
| Date: | 2014 - 2016 |
| Title: | Minimizing dose uncertainty for spot scanning proton beam of moving tumors by optimization of the spot delivery sequence |
| Funding Source: | Varian Medical Systems |
| Role: | Co-I |
| Date: | 2013 - 2014 |
| Title: | Predict and Adapt for Dose Variation in Spot Scanning Proton Therapy from Setup and Anatomical Change |
| Funding Source: | Varian Medical System |
| Role: | Co-I |
| Date: | 2012 - 2014 |
| Title: | In-Situ PET Imaging for Adaptive Proton Therapy |
| Funding Source: | CPRIT |
| Role: | Collaborator |
| ID: | RP120326 |
| Date: | 2008 - 2013 |
| Title: | Optimizing Proton Radiation Therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 2-P01CA021239 |
| Date: | 2008 - 2010 |
| Title: | Evaluation of Enhanced Spot Beam Model for IMPT and Production of Library of Reference Measured Dose Distribution Data for Evaluation of Future Enhancements of IMPT Treatment Planning System |
| Funding Source: | Varian Medical Systems |
| Role: | Co-project leader |
| Date: | 2006 - 2008 |
| Title: | Improve Cone beam imaging quality for image-guided radiation therapy |
| Funding Source: | Varian Medical Systems |
| Role: | Project Leader |
Selected Publications
Peer-Reviewed Articles
- Wang, H, Alsanea, FM, Rhee, DJ, Zhang, X, Liu, W, Yang, J, Wen, Z, Zhao, Y, Williamson, TD, Hunter, R, Balter, PA, Briere, TM, Zhu, XR, Lee, A, Moreno, AC, Reddy, JP, Garden, AS, Rosenthal, D, Gunn, GB, Phan, J. Advanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation. Cancers 17(3), 2025. e-Pub 2025. PMID: 39941906.
- Yang, D, Zhu, XR, Chen, M, Ma, L, Cheng, X, Grosshans, DR, Lu, W, Shao, Y. Investigation of intra-fractionated range guided adaptive proton therapy. Physics in medicine and biology 69(15), 2024. e-Pub 2024. PMID: 38861997.
- Chen, M, Yang, D, Zhu, XR, Ma, L, Grosshans, DR, Shao, Y, Lu, W. Investigation of intra-fractionated range guided adaptive proton therapy (RGAPT). Physics in medicine and biology 69(15), 2024. e-Pub 2024. PMID: 38861995.
- Corrigan KL, Xu T, Sasaki Y, Lin R, Chen AB, Welsh JW, Lin SH, Chang JY, Ning MS, Gandhi S, O’Reilly MS, Gay CM, Altan M, Lu C, Cascone T, Koutroumpakis E, Sheshadri S, Zhang X, Liao L, Zhu XR, Heymach JV, Q-N N, Liao Z. Survival outcomes and toxicity of adjuvant immunotherapy after definitive concurrent chemotherapy with proton beam radiation therapy for patients with inoperable locally advanced non-small cell lung carcinoma. Radiother Oncol 193:110121, 2024. e-Pub 2024.
- Sosa AJ, Rooney MK, Thames HD, Sanders JW, Swanson DM, Choi SL, Nguyen Q, Mok HM, Kuban DA, Zhu XR, Shah S, Mayo LL, Hoffman KE, Tang C, McGuire SE, Sahoo N, Zhang X, Lee AK, Pugh TJ, Mahmood U, Davis JW, Chapin B, Corn P, Kudchadker R, Ausat N, Frank AS. Proton Therapy toxicity outcomes for Localized Prostate Cancer: Long-term results at a comprehensive cancer center. Clin Trans Radiat Oncol 48:100822, 2024. e-Pub 2024.
- Wang L, Sanders J, Ward JF, Lee SR, Poenisch F, Swanson DM, Sahoo N, Zhu XR, Ma J, Kudchadker RJ, Choi SL, Nguyen Q, Mayo LL, Shah SJ, Frank SJ. A novel positive contrast multi-imaging modality fiducial marker for image-guided radiation therapy. Cancers 16(3):16030625, 2024. e-Pub 2024.
- Chen M, Yang D, Zhu XR, Ma L, Grosshans DR, Shao Y, Lu W. Investigation of intra-fractionated range guided adaptive proton therapy (RGAPT): II. Range-shift compensated on-line treatment adaptation and verification. Phys Med Biol 69:155006, 2024. e-Pub 2024.
- Yang D, Zhu XR, Chen M, Ma L, Cheng X, Grosshans DR, Lu W, Shao Y. Investigation of intra-fractionated range guided adaptive proton therapy: I. On-line PET imaging and range measurement. Phys Med Biol 69:155005, 2024. e-Pub 2024.
- Abouzahr F, Cesar JP, Crespo P, Gajda N, Hu Z, Klein K, Kuo AS, Majewski S, Mawlawi O, Morozov A, Ojha A, Poenisch F, Proga M, Sahoo N, Sec J, Takaoka T, Tavernier S, Titt U, Wang X, Zhu XR, and Lang K. The First Probe of a FLASH Proton Beam by PET. Phys Med Biol 68:2023, 2023. e-Pub 2023.
- Cao W, Li Y, Zhang X, Poenisch F, Yepes P, Sahoo N, Grosshans D, McGovern S, Gunn GB, Frank SJ, Zhu XR. Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma. J Appl Clin Med Phys 24(e13954):e13954, 2023. e-Pub 2023. PMID: 36913484.
- Chen, M, Cao, W, Yepes, P, Guan, F, Poenisch, F, Xu, C, Chen, J, Li, Y, Vazquez, I, Yang, M, Zhu, XR, Zhang, X. Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity-modulated proton therapy. Precision Radiation Oncology 7(1):36-44, 2023. e-Pub 2023. PMID: 40336617.
- Cao W, Li Y, Zhang X, Poenisch F, Yepes P, Sahoo N, Grosshasns D, McGovern S, Gunn BG, Frank S, and Zhu XRJ. Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma. J Appl Clin Med Phys(e13954), 2023. e-Pub 2023.
- Abouzahr F, Cesar JP, Crespo P, Gajda MJ, Hu Z, Kaye W, Klein K, Kuo A, Majewski S, Mawlawi OR, Morozov A, Ojha A, Poenisch F, Polf JC, Proga M, Sahoo N, Seco J, Takaoka T, Tavernier S, Titt U, Wang X, Zhu XR, and Lang K. The first PET glimpse of a proton FLASH beam. Phys Med Biol 68:125001, 2023. e-Pub 2023.
- Zhu XR, Li Y, Yang M, Taylor PA, Zhang X, Poenisch F, Sahoo N, Liao Z, and Chang JY. Stereotactic body proton therapy for early stage non-small cell lung cancer – technical challenges and solutions: the MD Anderson experience. J Radiosurg & SBRT 9:75-82, 2023. e-Pub 2023.
- Sosa AJ, Thames HD, Sanders JW, Choi S, Q-N N, Mok H, Zhu XR, Shah SJ, Mayo LL, Hoffman K, Tang C, Lee AK, Pugh TJ, Kudchadker R, Frank SJ. Proton therapy for the management of localized prostate cancer: Long-term clinical outcomes at a comprehensive cancer center. Radiother Oncol 188:109854, 2023. e-Pub 2023.
- Chen M, Cao W, Yepes P, Guan F, Poenisch F, Cheng X, Chen J, Li Y, Yang M, Zhu XR, and Zhang X. Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity-modulated proton therapy. Precision Radiat Oncol 7:36-44, 2023. e-Pub 2023.
- Vazquez I, Gronberg M, Zhang X, Court LE, Zhu XR, Frank SJ, and Yang M. A Deep Learning–Based Approach for Statistical Robustness Evaluation in Proton Therapy Treatment Planning: A Feasibility Study. Phys Med Biol 68:095014, 2023. e-Pub 2023.
- Yang M, Wang X, Guan F, Titt U, Iga K, Jiang D, Takaoka T, Tootake S, Katayose T, Umezawa M, Schüler E, Frank S, Lin SH, Sahoo N, Koong AC, Mohan R, Zhu XR. Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments. Phys Med Biol 67:165002, 2022. e-Pub 2022.
- Titt U, Yang M, Wang X, Iga K, Fredette N, Schueler E, Lin SH, Zhu XR, Sahoo N, Koong AC, Zhang X, and Mohan R. Design and validation of a synchrotron proton beam line for FLASH radiotherapy preclinical research experiments. Med Phys 49:497-509, 2022. e-Pub 2022.
- Chen M, Wang Z, Jiang S, Sun J, Wang L, Sahoo N, Gunn GB, Frank SJ, Xu C, Chen J, Q-N N, Chang JY, Liao Z, Zhu XR, and Zhang X. Predictive performance of different NTCP techniques for radiation‑induced esophagitis in NSCLC patients receiving proton radiotherapy. Scientific Reports 12:9178, 2022. e-Pub 2022.
- Cao J, Zhang X, Jinag B, Chen J, Wang X, Wang L, Sahoo N, Zhu XR, Ye R, Blanchard P, Garden AS, Fuller CD, Gunn GB, and Frank SJ. Intensity-modulated proton therapy for oropharyngeal cancer reduces rates of late xerostomia. Radiother Radonc 160:32-39, 2021. e-Pub 2021.
- Gunn GB, Garden AS, Ye R, Ausat N, Dahlstrom KR, Morrison WH, Fuller CD, Phan J, Reddy JP, Shah SJ, Mayo LL, Chun SG, Chronowski GM, Moreno AC, Myers JN, Hanna EY, Esmaeli B, Gillison ML, Ferrarotto R, Hutcheson KA, Chambers MS, Ginsberg LE, El-Naggar AK, Rosenthal DI, Zhu XR, Frank SJ. Proton Therapy for Head and Neck Cancer: A 12-Year, Single-Institution Experience. Int J Part Ther 20(00065.1):108-118, 2021. e-Pub 2021. PMID: 34285940.
- Taku N, Wang L, Garden AS, Rosenthal DI, Gunn GB, Morrison WH, Fuller CD, Phan J, Reddy JP, Moreno AC, Spiotto MT, Chronowski G, Shah SJ, Mayo LL, Gross ND, Ferrarotto R, Zhu XR, Zhang X, Frank SJ. Proton Therapy for HPV-Associated Oropharyngeal Cancers of the Head and Neck: a De-Intensification Strategy. Curr Treat Options Oncol 22(6):54, 2021. e-Pub 2021.
- Siochi RA, Balter P, Bloch CD, Santanam L, Blodgett K, Curran BH, Engelsman M, Feng W, Mechalakos J, Pavord D, Simon T, Sutlief S, Zhu XR. Share Report of Task Group 201 of the American Association of Physicists in Medicine: Quality management of external beam therapy data transfer. Med Phys 48(6):e86-e114, 2021. e-Pub 2021.
- Farr JB, Moyers MF, Allgower CE, Bues M, Hsi WC, Jin H, Mihailidis DN, Lu HM, Newhauser WD, Sahoo N, Slopsema R, Yeung D, Zhu XR. Clinical commissioning of intensity-modulated proton therapy systems: Report of AAPM Task Group 185. Med Phys:doi: 10.1002/mp.145, 2020. e-Pub 2020.
- Gjyshi O, Xu T, Elhammali A, Boyce-Fappiano D, Chun SG, Gandhi S, Lee P, Chen AB, Lin SH, Chang JY, Tsao A, Gay CM, Zhu XR, Zhang X, Heymach JV, Fossella FV, Lu C, Nguyen QN, Liao Z. Toxicity and Survival After Intensity-Modulated Proton Therapy Versus Passive Scattering Proton Therapy for NSCLC. J Thorac Oncol:S1556-0864(20)30839-X, 2020. e-Pub 2020.
- Chen M, Yang J, Liao Z, Chen J, Xu C, He X, Zhang X, Zhu XR, Li H. Anatomic change over the course of treatment for non-small cell lung cancer patients and its impact on intensity-modulated radiation therapy and passive-scattering proton therapy deliveries. Radiat Oncol 15(1):10.1186/s13014-020-01503-9, 2020. e-Pub 2020.
- Chen M, Yepes P, Hojo Y, Poenisch F, Li Y, Chen J, Xu C, He X, Gunn GB, Frank SJ, Sahoo N, Li H, Zhu XR, Zhang X. Transitioning from measurement-based to combined patient-specific quality assurance for intensity-modulated proton therapy. Br J Radiol 93(1107):20190669, 2020. e-Pub 2020. PMID: 31799859.
- Wang L, Yang L, Han S, Zhu J, Li Y, Wang Z, Fan YH, Lin E, Zhang R, Sahoo N, Li Y, Zhang X, Wang X, Li T, Zhu XR, Zhu H, Heymach JV, Myers JN, Frank SJ. Patterns of protein expression in human head and neck cancer cell lines differ after proton vs photon radiotherapy. Head Neck 42(2):289-301, 2020. e-Pub 2020. PMID: 31710172.
- Wu RY, Liu AY, Yang J, Williamson TD, Wisdom PG, Bronk L, Gao S, Grosshan DR, Fuller DC, Gunn GB, Zhu XR, Frank SJ. Evaluation of the accuracy of deformable image registration on MRI with a physical phantom. J Appl Clin Med Phys 21(1):166-173, 2020. e-Pub 2020.
- Wu RY, Williamson TD, Sahoo N, Nguyen T, Ikner SM, Liu AM, Wisdom PG, Lii M, Hunter RA, Alvarez PE, Gunn GB, Frank SJ, Jojo Y, Zhu XR, Gillin MT. Evaluation of the high definition field of view option of a large-bore computed tomography scanner for radiation therapy simulation. Phys Imag Rad Oncol 13(44-49), 2020. e-Pub 2020.
- Yang Z, Zhang X, Wang X, Zhu XR, Gunn B, Frank SJ, Chang Y, Li Q, Yang K, Wu G, Liao L, Li Y, Chen M, and Li H. Multiple-CT optimization: An adaptive optimization method to account for anatomical changes in intensity-modulated proton therapy for head and neck cancers. Radiother Oncol 142(124-132), 2020. e-Pub 2020.
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- Liu W, Frank SJ, Li X, Li Y, Zhu XR, and Mohan R. PTV-based IMPT optimization incorporating planning risk volumes vs robust optimization. Med Phys 40:021709-1-8, 2013. e-Pub 2013.
- Pugh TJ, Choi S, Nguyen QN, Gillin MT, Zhu XR, Palmer BP, and Lee AK. Proton Beam Therapy for the Treatment of Prostate Cancer. Practical Radiat Oncol 3:e87-e94, 2013. e-Pub 2013.
- Pugh TJ, Amos RA, John Baptiste S, Choi S, Nhu Nguyen Q, Ronald Zhu X, Palmer MB, Lee AK. Multifield optimization intensity-modulated proton therapy (MFO-IMPT) for prostate cancer: Robustness analysis through simulation of rotational and translational alignment errors. Med Dosim Jun 6(3):pii: S0958-3947(13) 00043-5, 2013. e-Pub 2013. PMID: 23747223.
- Kandula S, Zhu X, Garden AS, Gillin M, Rosenthal DI, Ang KK, Mohan R, Amin MV, Garcia JA, Wu R, Sahoo N, Frank SJ. Spot-scanning beam proton therapy vs intensity-modulated radiation therapy for ipsilateral head and neck malignancies: A treatment planning comparison. Med Dosim 38(4)(4):390-4, 2013. e-Pub 2013. PMID: 23916884.
- Li H, Li Y, Zhang X, Li X, Liu W, Gillin MT, Zhu XR. Dynamically accumulated dose and 4D accumulated dose for moving tumors. Med Phys 39(12):7359-7367, 2012. e-Pub 2012. PMID: 23231285.
- Amsbaugh MJ, Zhu XR, Palmer M, Poenisch F, McAleer MF, Mahajan A, Grosshans DR. Spot scanning proton therapy for craniopharyngioma. Pract Radiat Oncol 2(4):314-318, 2012. e-Pub 2012. PMID: 24674170.
- Amsbaugh MJ, Grosshans DR, McAleer MF, Zhu R, Wages C, Crawford CN, Palmer M, De Gracia B, Woo S, Mahajan A. Proton Therapy for Spinal Ependymomas: Planning, Acute Toxicities and Preliminary Outcomes. Int J Radiat Oncol Biol Phys 83(5):1419-1424, 2012. e-Pub 2012. PMID: 22245209.
- Cao W, Lim GJ, Lee A, Li Y, Liu W, Ronald Zhu X, Zhang X. Uncertainty incorporated beam angle optimization for IMPT treatment planning. Med Phys 39(8):5248-5256, 2012. e-Pub 2012. PMID: 22894449.
- Yang M, Zhu XR, Park PC, Titt U, Mohan R, Virshup G, Clayton JE, Dong L. Comprehensive analysis of proton range uncertainties related to patient stopping-power-ratio estimation using the stoichiometric calibration. Phys Med Biol 57(13):4095-4115, 2012. e-Pub 2012. PMID: 22678123.
- Park PC, Cheung J, Zhu XR, Sahoo N, Court L, Dong L. Fast range-corrected proton dose approximation method using prior dose distribution. Phys Med Biol 57(11):3555-3569, 2012. e-Pub 2012. PMID: 22588165.
- Park PC, Zhu XR, Lee AK, Sahoo N, Melancon AD, Zhang L, Dong L. A Beam-specific planning target volume (PTV) design for proton therapy to account for setup and range uncertainties. Int J Radiat Oncol Biol Phys 82(2):e329-e336, 2012. e-Pub 2012. PMID: 21703781.
- Anand A, Sahoo N, Zhu XR, Sawakuchi GO, Poenisch F, Amos RA, Ciangaru G, Titt U, Suzuki K, Mohan R, Gillin MT. A procedure to determine the planar integral spot dose values of proton pencil beam spots. Med Phys 39(2):891-900, 2012. e-Pub 2012. PMID: 22320798.
- Li Y, Zhu XR, Sahoo N, Anand A, Zhang X. Beyond Gaussians: a study of single spot modeling for scanning proton dose calculation. Phys Med Biol 57:983-997, 2012. e-Pub 2012.
- Zhang X, Liu W, Li Y, Li X, Quan M, Mohan R, Anand A, Sahoo N, Gillin M, Zhu XR. Parameterization of multiple Bragg curves for scanning proton beams using simultaneous fitting of multiple curves. Phys Med Biol 56(24):7725-7735, 2011. e-Pub 2011. PMID: 22085829.
- Welsh J, Gomez D, Palmer MB, Riley BA, Mayankkumar AV, Komaki R, Dong L, Zhu XR, Likhacheva A, Liao Z, Hofstetter WL, Ajani JA, Cox JD. Intensity-Modulated Proton Therapy Further Reduces Normal-Tissue Exposure During Definitive Therapy for Locally Advanced Distal Esophageal Tumors: A Dosimetric Study. Int J Radiat Oncol Biol Phys 81(5):1336-1342, 2011. e-Pub 2011. PMID: 21470796.
- Li H, Dong L, Zhang L, Yang JN, Gillin MT, Zhu XR. Toward a better understanding of the gamma index: Investigation of parameters with a surface-based distance method. Med Phys 38(12):6730-41, 2011. e-Pub 2011. PMID: 22149855.
- Zhu XR, Poenisch F, Song X, Johnson JL, Ciangaru G, Taylor MB, Lii M, Martin C, Arjomandy B, Lee AK, Choi S, Nguyen QN, Gillin MT, Sahoo N. Patient-specific quality assurance for prostate cancer patients receiving spot scanning proton therapy using single-field uniform dose. Int J Radiat Oncol Biol Phys 81(2):552-559, 2011. e-Pub 2011. PMID: 21300457.
- Huang JY, Newhauser WD, Zhu XR, Lee AK, Kudchadker RJ. Investigation of dose perturbations and the radiographic visibility of potential fiducials for proton radiation therapy of the prostate. Phys Med Biol 56(16):5287-302, 2011. e-Pub 2011. PMID: 21799236.
- Suzuki K, Gillin MT, Sahoo N, Zhu XR, Lee AK, Lippy D. Quantitative analysis of beam delivery parameters and treatment process time for proton beam therapy. Med Phys 38(7):4329-4337, 2011. e-Pub 2011. PMID: 21859034.
- Li H, Lee AK, Johnson JL, Zhu RX, Kudchadker RJ. Characterization of dose impact on IMRT and VMAT from couch attenuation for two Varian couches. J Appl Clin Med Phys 12(3):3471, 2011. e-Pub 2011. PMID: 21844859.
- Siochi RA, Balter P, Bloch CD, Santanam L, Blodgett K, Curran BH, Engelsman M, Feng W, Mechalakos J, Pavord D, Simon T, Sutlieff S, Zhu XR. A rapid communication from the AAPM Task Group 201: Recommendations for the QA of external beam radiotherapy data transfer. AAPM TG 201: Quality assurance of external beam radiotherapy data transfer. J Appl Clin Med Phys 22(1):170-181, 2011. e-Pub 2011. PMID: 21330992.
- Cheung J, Kudchadker RJ, Zhu XR, Lee AK, Newhauser WD. Dose perturbations and image artifacts caused by carbon-coated ceramic and stainless steel fiducials used in proton therapy for prostate cancer. Phys Med Biol 55(23):7135-47, 2010. e-Pub 2010. PMID: 21076190.
- Li H, Zhang L, Dong L, Sahoo N, Gillin MT, Zhu XR. A CT-based software tool for evaluating compensator quality in passively scattered proton therapy. Phys Med Biol 55(22):6759-6771, 2010. e-Pub 2010. PMID: 21030745.
- Meyer J, Bluett J, Amos R, Levy L, Choi S, Nguyen QN, Zhu XR, Gillin M, Lee A. Spot scanning proton beam therapy for prostate cancer: treatment planning technique and analysis of consequences of rotational and translational alignment errors. Int J Radiat Oncol Biol Phys 78(2):428-34, 2010. e-Pub 2010. PMID: 20100641.
- Sawakuchi GO, Mirkovic D, Perles LA, Sahoo N, Zhu XR, Ciangaru G, Suzuki K, Gillin MT, Mohan R, Titt U. An MCNPX Monte Carlo model of a discrete spot scanning proton beam therapy nozzle. Med Phys 37(9):4960-4970, 2010. e-Pub 2010. PMID: 20964215.
- Sawakuchi GO, Zhu XR, Poenisch F, Suzuki K, Ciangaru G, Titt U, Anand A, Mohan R, Gillin MT, Sahoo N. Experimental characterization of the low-dose envelope of spot scanning proton beams. Phys Med Biol 55(12):3467-3478, 2010. e-Pub 2010. PMID: 20508318.
- Wang X, Sahoo N, Zhu RX, Zullo JR, Gillin MT. Measurement of neutron dose equivalent and its dependence on beam configuration for a passive scattering proton delivery system. Int J Radiat Oncol Biol Phys 76(5):1563-70, 2010. e-Pub 2010. PMID: 20097484.
- Yang M, Virshup G, Clayton J, Zhu XR, Mohan R, Dong L. Theoretical variance analysis of single- and dual-energy computed tomography methods for calculating proton stopping power ratios of biological tissues. Phys Med Biol 55(5):1343-1362, 2010. e-Pub 2010. PMID: 20145291.
- Zhu XR, Sahoo N, Zhang X, Robertson D, Li H, Choi S, Lee AK, Gillin MT. Intensity modulated proton therapy treatment planning using single field optimization: the impact of monitor unit constraints on plan quality. Med Phys 37(3):1210-1219, 2010. e-Pub 2010. PMID: 20384258.
- Sawakuchi GO, Titt U, Mirkovic D, Ciangaru G, Zhu XR, Sahoo N, Gillin MT, Mohan R. Monte Carlo investigation of the low-dose envelope from scanned proton pencil beams. Phys Med Biol 55(3):711-21, 2010. e-Pub 2010. PMID: 20071752.
- Gillin MT, Sahoo N, Bues M, Ciangaru G, Sawakuchi G, Poenisch F, Arjomandy B, Martin C, Titt U, Suzuki K, Smith AR, Zhu XR. Commissioning of the discrete spot scanning proton beam delivery system at The University of Texas M. D. Anderson Cancer Center, Proton Therapy Center, Houston. Med Phys 37(1):154-163, 2010. e-Pub 2010. PMID: 20175477.
- Arjomandy B, Sahoo N, Ciangaru G, Zhu XR, Song XR, Gillin MT. Verification of patient-specific dose distributions in proton radiotherapy using a two-dimensional commercial ion chamber array. Med Phys 37:5831-5837, 2010. e-Pub 2010.
- Zullo JR, Kudchadker RJ, Zhu XR, Sahoo N, Gillin MT. LIF TLD-100 as a dosimeter in high energy proton beam therapy-Can it yield accurate results?. Med Dosim 35(1):63-6, 2010. e-Pub 2010. PMID: 19931017.
- Ciangaru G, Sahoo N, Zhu XR, Sawakuchi GO, Gillin MT. Computation of doses for large-angle Coulomb scattering of proton pencil beams. Phys Med Biol 54(24):7285–7300, 2009. e-Pub 2009. PMID: 19926912.
- Smith A, Gillin M, Bues M, Zhu XR, Suzuki K, Mohan R, Woo S, Lee A, Komaki R, Cox J, Hiramoto K, Akiyama H, Ishida T, Sasaki T, Matsuda K. The M. D. Anderson proton therapy system. Med Phys 36(9):4068-4083, 2009. e-Pub 2009. PMID: 19810479.
- Giebeler A, Fontenot J, Balter P, Ciangaru G, Zhu XR, Newhauser W. Dose perturbations from by implanted helical gold markers in proton therapy of prostate cancer. J App Clin Med Phys 10(1):63-70, 2009. e-Pub 2009.
- Li H, Mawlawi OS, Zhu XR, and Zheng Y. Blind Deblurring Reconstruction Technique with Applications in PET Imaging. Int J Biomed Imag 2009(78157):1-6, 2009. e-Pub 2009.
- Li H, Mohan R, Zhu XR. Scatter kernel estimation with an edge-spread function method for cone-beam computed tomography imaging. Phys Med Biol 53(23):6729-48, 2008. e-Pub 2008. PMID: 18997269.
- Sahoo N, Zhu XR, Arjomandy B, Ciangaru G, Lii M, Amos R, Wu R, Gillin MT. A procedure for calculation of monitor units for passively scattered proton radiotherapy beams. Med Phys 35(11):5088-97, 2008. e-Pub 2008. PMID: 19070243.
- Titt U, Sahoo N, Ding X, Zheng Y, Newhauser WD, Zhu XR, Polf JC, Gillin MT, Mohan R. Assessment of the accuracy of an MCNPX-based Monte Carlo simulation model for predicting three-dimensional absorbed dose distributions. Phys Med Biol 53(16):4455-4470, 2008. e-Pub 2008. PMID: 18670050.
- Li H, Zhu XR, Zhang L, Dong L, Tung S, Ahamad A, Chao KS, Morrison WH, Rosenthal DI, Schwartz DL, Mohan R, Garden AS. Comparison of 2D radiographic images and 3D cone beam computed tomography for positioning head-and-neck radiotherapy patients. Int J Radiat Oncol Biol Phys 71(3):916-25, 2008. e-Pub 2008. PMID: 18395358.
- Yang M, Virshup G, Mohan R, Shaw CC, Zhu XR, Dong L. Improving accuracy of electron density measurement in the presence of metallic implants using orthovoltage computed tomography. Med Phys 35(5):1932-1941, 2008. e-Pub 2008. PMID: 18561669.
- Li Y, Zhang X, Lii M, Sahoo N, Zhu XR, Gillin MT, Mohan R. Incorporating partial shining effects in proton pencil beam dose calculation. Phys Med Biol 53:605-616, 2008. e-Pub 2008.
- Zhu XR, Gillin MT. Effect of output variation with dose rate on the Virtual Wedge factor. J Appl Clin Med Phys 9(1):54-58, 2008. e-Pub 2008. PMID: 18449167.
- Lu J, Guerrero TM, Munro P, Jeung A, Chi PM, Balter P, Zhu XR, Mohan R, Pan T. Four dimensional cone beam CT with adaptive gantry rotation and adaptive data sampling. Med Phys 34(9):3520-3529, 2007. e-Pub 2007. PMID: 17926955.
- Zhang Y, Zhang L, Zhu XR, Lee AK, Chambers M, Dong L. Reducing metal artifacts in cone-beam CT images by preprocessing projection data. Int J Radiat Oncol Biol Phys 67(3):924-32, 2007. e-Pub 2007. PMID: 17161556.
- Kang Y, Zhang X, Chang JY, Wang H, Wei X, Liao Z, Komaki R, Cox JD, Balter PA, Liu H, Zhu XR, Mohan R, Dong L. 4D Proton treatment planning strategy for mobile lung tumors. Int J Radiat Oncol Biol Phys 67(3):906-14, 2007. e-Pub 2007. PMID: 17293240.
- Zhang X, Dong L, Lee A, Cox J, Kuban DA, Zhu XR, Wang X, Li Y, Newhauser WD, Gillin M, Mohan R. Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatment. Int J Radiat Oncol Biol Phys 67:620-629, 2007. e-Pub 2007.
- Wang D, Schultz CJ, Jursinic PA, Bialkowski M, Zhu XR, Brown WD, Rand SD, Michel MA, Campbell BH, Wong S, Li XA, Wilson JF. Initial experience of FDG-PET/CT guided IMRT of head-and-neck carcinoma. Int J Radiat Oncol Biol Phys 65(1):143-51, 2006. e-Pub 2006. PMID: 16618577.
- Zhang L, Garden AS, Lo J, Ang KK, Ahamad A, Morrison WH, Rosenthal DI, Chambers MS, Zhu XR, Mohan R, Dong L. Multiple regions-of-interest analysis of setup uncertainties for head-and-neck cancer radiotherapy. Int J Radiat Oncol Biol Phys 64(5):1559-69, 2006. e-Pub 2006. PMID: 16580505.
- Zhu XR, Kang Y, Gillin MT. Measurement of in-air output ratios for a linear accelerator with and without the flattening filter. Med Phys 33:3723-3733, 2006. e-Pub 2006.
- Zhu XR, Gillin MT. Derivation of the distribution of extrafocal radiation for head scatter factor calculation. Med Phys 32:351-9, 2005. e-Pub 2005. PMID: 15789579.
- Zhu XR, Prado K, Liu HH, Guerrero TM, Jeter M, Liao Z, Rice D, Forster K, Stevens CW. Intensity-modulated radiation therapy for mesothelioma: impact of multileaf collimator leaf width and pencil beam size on planning quality and delivery efficiency. Int J Radiat Oncol Biol Phys 62(5):1525-34, 2005. e-Pub 2005. PMID: 16029815.
- York ED, Alecu R, Ding L, Fontenla DP, Kalend AM, Kaurin DG, Masterson-McGary ME, Saini AS, Shi J, Simon WE, Zhu TC, Zhu XR. Diode In-vivo dosimetry for patients receiving external beam radiation therapy. AAPM Report No. 87, 2005. e-Pub 2005.
- Stevens CW, Wong PF, Rice D, Jeter M, Forster K, Zhu XR. Treatment planning system evaluation for mesothelioma IMRT. Lung Cancer 49 Suppl 1:S75-81, 2005. e-Pub 2005. PMID: 15950806.
- Zhu XR Schultz CS, Gillin MT. Planning quality and delivery efficiency of sMLC delivered IMRT treatment of oropharyngeal cancers evaluated by RTOG H-0022 dosimetric criteria. J Appl Clin Med Phys 5(4):80-95, 2004. e-Pub 2004. PMID: 15738923.
- Zhu XR, Yoo S, Jursinic PA, Grimm DF, Lopez F, Rownd JJ, Gillin MT. Characteristics of sensitometric curves of radiographic films. Med Phys 30(5):912-919, 2003. e-Pub 2003. PMID: 12773000.
- Yoo S, Grimm DF, Zhu XR, Jursinic PA, Lopez F, Rownd JJ, Gillin MT. Clinical Implementation of AAPM TG61 new protocol for kilovoltage x-ray radiation therapy beams. Med Phys 29:2269-2273, 2002. e-Pub 2002.
- Zhu XR, Gillin MT, Ehlers K, Lopez F, Grimm DF, Rownd JJ, Steinberg TH. Dependence of Virtual wedge factor on dose calibration and monitor units. Med Phys 28(2):174-177, 2001. e-Pub 2001. PMID: 11243340.
- Zhu XR, Gillin MT, Jursinic PA, Lopez F, Grimm DF, Rownd JJ. Comparison of dosimetric characteristics of Siemens Virtual and physical wedges. Med Phys 27(10):2267-2277, 2000. e-Pub 2000. PMID: 11099193.
- Miften M, Zhu XR, Takahashi K, Lopez F, Gillin MT. Implementation and verification of virtual wedge in a three-dimensional radiotherapy planning system. Med Phys 27(7):1635-43, 2000. e-Pub 2000. PMID: 10947267.
- Zhu XR, Allen JJ, Shi J, Simon WE. Total scatter factors and tissue maximum ratios for small radiosurgery fields: comparison of diode detectors, a parallel-plate ion chamber, and radiographic film. Med Phys 27(3):472-477, 2000. e-Pub 2000. PMID: 10757599.
- Zhu XR. Entrance dose measurements for in-vivo dosimetry: comparison of correction factors for two types of commercial silicon diode detectors. J App Clin Med Phys 1:100-107, 2000. e-Pub 2000.
- Tinger A, Michalski JM, Cheng A, Low DA, Zhu XR, Bosch WR, Purdy JA, Perez CA. A critical evaluation of the planning target volume for 3-D conformal radiotherapy of prostate cancer. Int J Radiat Oncol Biol Phys 42:213-221, 1998. e-Pub 1998.
- Hansen RL, Zhu XR, Harris JM. Fluorescence Correlation Spectroscopy with Patterned Photoexcitation for Measuring Solution Diffusion Coefficients of Robust Fluorophores. Anal Chem 70:1281-1287, 1998. e-Pub 1998.
- Zhu XR, Klein EE, Low DA. Geometric and dosimetric analysis of multileaf collimation conformity. Radiother Oncol 47:63-8, 1998. e-Pub 1998. PMID: 9632294.
- Klein EE, Gerber R, Zhu XR, Oehmke F, Purdy JA. Multiple machine implementation of enhanced dynamic wedge. Int J Radiat Oncol Biol Phys 40:977-85, 1998. e-Pub 1998. PMID: 9531384.
- Low DA, Zhu XR, Purdy JA, Soderstrom S. The influence of angular misalignment on fixed-portal intensity modulated radiation therapy. Med Phys 24:1123-39, 1997. e-Pub 1997. PMID: 9243475.
- Low DA, Zhu XR, Harms WB, Purdy JA. Measurement of a photon penumbra-generating kernel for a convolution-adapted ratio-TAR algorithm for 3D treatment planning. Med Phys 22(9):1395-403, 1995. e-Pub 1995. PMID: 8531864.
- Zhu XR, Low DA, Harms WB, Purdy JA. A convolution-adapted ratio-TAR algorithm for 3D photon beam treatment planning. Med Phys 22(8):1315-27, 1995. e-Pub 1995. PMID: 7476719.
- Cambron RT, Zhu XR, Harris JM. Evaluating Rates and Yields of Second-order, Photoinitiated Reactions under Conditions of Gaussian-profile Excitation. J Phys Chem 98:8726-8733, 1994. e-Pub 1994.
- Zulli SL, Kovaleski JM, Zhu XR, Harris JM, Wirth MJ. Lateral Diffusion of an Adsorbate at a Chromatographic C18/Water Interface. Anal Chem 66:66, 1994. e-Pub 1994.
- Zhu XR, Harris JM. Formation, Relaxation, and Quenching of Br2 Excited States in CCl4. J Phys Chem 97:6650-6655, 1993. e-Pub 1993.
- Zhu XR, McGraw DJ, Harris JM. Holographic Spectroscopy: Diffraction from Laser-induced Gratings. Anal Chem 64:710A-719A, 1992. e-Pub 1992.
- Zhu XR, Harris JM. Photodissociation and Nongeminate Recombination of Bromine in Liquids Initiated by 532 nm Radiation. Chem Phys Lett 186:183-188, 1991. e-Pub 1991.
- Zhu XR, Harris JM. Photothermal Grating Spectroscopy Study of Nongeminate Atom Recombination of Photodissociated Iodine in Liquids. Chem Phys 157:409-422, 1991. e-Pub 1991.
- Zhu XR, Harris JM. Diffraction from Anharmonic Gaussian Volume Gratings Calculated by Two-dimensional Fourier Transform to Evaluate Optical Nonlinear Absorption. J Opt Soc Am B7:796-802, 1990. e-Pub 1990.
- Zhu XR, Harris JM. Studies of Excited-state Absorption and photoisomerization of Cyanine Dye Molecules by Laser-induced Anharmonic Thermal Gratings. Chem Phys 142:301-309, 1990. e-Pub 1990.
- Zhu XR, Harris JM. Nonlinear Absorption By All-trans-b-carotene Studied by Diffraction from Laser-induced Anharmonic Thermal Gratings. J Phys Chem 93:75-83, 1989. e-Pub 1989.
- Zhu XR, Harris JM. Influence of Photoisomerization on Saturated Absorption of 3,3'-Diethyloxadicarbocyanine Iodide (DODCI) Studied by Diffraction from Laser-induced Anharmonic Thermal Gratings. Chem Phys 124:321-332, 1988. e-Pub 1988.
- Wang CH Zhu XR, Shen JC. Angular and Temperature Dependence of Depolarized and Polarized Rayleigh-Brillouin Spectra of a Supercooled Liquid: o-terphenyl. Mol Phys 62:749-764, 1987. e-Pub 1987.
- Zhu XR, Wang CH. Homodyne Photon-correlation Spectroscopy of a supercooled liquid: 1,3,5-tri-a-Naphthyle Benzene. J Chem Phys 84:6086-6090, 1986. e-Pub 1986.
- Guan F, Jiang D, Wang X, Yang M, Iga K, Li Y, Bronk L, Bronk J, Wang L, Guo Y, Sahoo N, Grosshans DR, Koong AC, Zhu XR, Mohan R. Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform.
- Liang DF, Vazquez I, Gronberg M, Zhang X, Zhu ZR, Frank SJ, Court LE, Martel M, and Yang M. Deep Learning–Based Statistical Robustness Evaluation of Intensity-Modulated Proton Therapy for Head and Neck Cancer. Phys Med Biol.
- Cesar JP, Abouzahr F, Crespo P, Gajda M, Kuo A, Mawlawi O, Morozov A, Ojha A, Poenisch F, Proga M, Sahoo N, Seco J, Takaoka T, Tavienier S, Titt U, Wang X, Zhu XR, Lang K. First PET Studies of a FLASH Proton Beam: Summary and Future Prospects. Bio-Algorithms and Med-Systems.
- Vazquez I, Liang D, Salazar RM, Gronberg MP, Sjogree C, Williamson TD, Whitaker TJ, Zhu XR, Frank SJ, Court LE, and Yang M. Deep Learning Techniques for Proton Dose Prediction Across Multiple Anatomical Sites and Variable Beam Configurations. Phys Med Biol.
Invited Articles
- Sapareto S, Zhu XR, Orton CG. Point/counterpoint. Medical physics residents should be placed using a matching program. Med Phys 41(6):060601, 2014. e-Pub 2014. PMID: 24877794.
- Zhu XR, Das RK, Orton CG. POINT/COUNTERPOINT - Most residency programs for radiation oncology physicists do not reflect the heightened importance of medical imaging. Med Phys 37(5):1939-1941, 2010. e-Pub 2010. PMID: 20527527.
Review Articles
- Pollard-Larkin JM, Briere TM, Kudchadker RJ, Sadagopan R, Nitsch PL, Wang XA, Salehpour M, Wang J, Vedam S, Nelson CL, Sahoo N, Zhu XR, Court LE, Balter PA, Robinson IJ, Yang J, Howell RM, Followill DS, Kry S, Beddar SA, Martel MK. Our Experience Leading a Large Medical Physics Practice During the COVID-19 Pandemic. Adv Radiat Oncol 6(4):100683, 2021. e-Pub 2021. PMID: 33824935.
- Chuong MD, Hallemeier CL, Li H, Zhu XR, Zhang X, Tryggestad EJ, Yu J, Yang M, Choi JI, Kang M, Liu W, Knopf A, Meijers A, Molitoris JK, Apisarnthanarax S, Giap H, Hoppe BS, Lee P, Chang JY, Simone CB, Lin SH. Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy from the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees. Front Oncol 11:748331, 2021. e-Pub 2021. PMID: 34737959.
- Chang JY, Zhang X, Knopf A, Li H, Mori S, Dong L, Lu HM, Liu W, Badiyan SN, Both S, Meijers A, Lin L, Flampouri S, Li Z, Umegaki K, Simone CB, Zhu XR. Consensus Guidelines for Implementing Pencil-Beam Scanning Proton Therapy for Thoracic Malignancies on Behalf of the PTCOG Thoracic and Lymphoma Subcommittee. Int J Radiat Oncol Biol Phys 99(1):41-50, 2017. e-Pub 2017. PMID: 28816159.
- Chang JY, Jabbour SK, De Ruysscher D, Schild SE, Simone CB, Rengan R, Feigenberg S, Khan AJ, Choi NC, Bradley JD, Zhu XR, Lomax AJ, Hoppe BS, Thoracic Subcommittee IPTCG. Consensus Statement on Proton Therapy in Early-Stage and Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 95(1):505-516, 2016. e-Pub 2016. PMID: 27084663.
- Zhu XR, Li Y, Mackin D, Li H, Poenisch F, Lee AK, Mahajan A, Frank SJ, Gillin MT, Sahoo N, Zhang X. Towards effective and efficient patient-specific quality assurance for spot-scanning proton therapy. Cancers (Basel) 7(2):631-647, 2015. e-Pub 2015. PMID: 25867000.
- Arjomandy B, Sahoo N, Zhu XR, Zullo JR, Wu RY, Zhu M, Ding X, Martin C, Ciangaru G, Gillin MT. An overview of the comprehensive proton therapy machine quality assurance procedures implemented at the University of Texas M. D. Anderson Cancer Center Proton Therapy Center-Houston. Med Phys 36(6):2269-2282, 2009. e-Pub 2009. PMID: 19610316.
Other Articles
- Giebeler A, Fontenot J, Balter P, Ciangaru G, Zhu XR, and Newhauser W Assessment of implanted helical gold markers for patients receiving proton radiotherapy for prostate cancer. Transactions of the American Nuclear Society 99:578-579, 2008.
- Li H, Qiao F, Mawlawi OR, Zheng Y, and Zhu XR Blind deblurring reconstruction technique with applications in PET imaging. Proceedings of the 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI '07) 9(7):173-176, 2007.
- Li H, Zhu XR, Liu R, Wu R, Mohan R CT number uncertainty in proton radiation therapy. Proceedings of IEEE 2007 Nuclear Science Symposium and Medical Imaging Conferenece (NSS/MIC 2007), 2007.
- Lu J, Zhu XR, Munro P, Chi PM, Mohan R, Pan T Amplitude correlated 4-dimentional cone beam CT. Proc SPIE 6142:864-874, 2006.
- Li H, Mohan R, and Zhu XR Derivation of Scatter Kernel in CBCT Imaging System. Proceedings of IEEE 2006 Asilomar Conference on Signals, Systems, and Computers:1851-1854, 2006.
- Miften M, Zhu XR, Takahashi K, Lopez F, Gillin NMT Calculation of dose distributions with constraint checking for siemens virtual wedge. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 4:3204-3205, 2000.
- Zhu XR, Gillin MT, Lopez F, Grimm DF, and Rownd JJ Comparison of dosimetric properties of virtual wedge and physical wedges. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 4:2539-2541, 2000.
- Miften MM, Zhu XR, Takahashi K, Lopez F, Gillin MT Siemens Virtual Wedge: A dose calculation model with constraint checking. Proceedings of the 13th International Conference on the Use of Computers in Radiation Therapy:372-374, 2000.
- Zhu XR, Low DA, Harms WB, Purdy JA 3-D Conformal Radiation Therapy: III. A Convolution Method to Ratio TAR Algorithm for Photon Beam Treatment Planning. Proceedings of the 11th International Conference on Computers in Radiation Therapy, Manchester, UK:232-234, 1994.
- Low DA, Zhu XR, Harms WB, Matthews JW, Purdy JA, Cheng A, Gerber RL Evaluation of Ratio-TAR Photon and Electron Pencil Beam Dose Calculation Algorithms for 3D Treatment Planning. Proceedings of the 11th International Conference on Computers in Radiation Therapy Manchester, UK:372-374, 1994.
- Zhu XR, Harris JM Nonlinear Absorption in Liquid Studied by Laser-induced Anharmonic Thermal Gratings. Advances in Laser Science - IV:360-362, 1989.
Abstracts
- Wu R, Crowford C, Georges R, Liu A, Amin M Sio T, Gunn B, Poenisch F, Palmer M, Gillin M, Frank S, Zhu X. SU-F-T-195: Systematic Constraining of Contralateral Parotid Gland Led to Improved Dosimetric Outcomes for Multi-Field Optimization with Sanning Beam Proton Therapy: Promising Results From a Pilot Study in Patients with Base of Tongue Carcinoma. Med Phys 43(6):3506-3507, 2016. e-Pub 2016. PMID: 28048650.
- Zhu X. WE-E-EBR-01: Personalized Motion Management Strategies for Pencil Beam Scanning Proton Therapy. Med Phys 43(6):3821, 2016. e-Pub 2016. PMID: 28048461.
- Ager B, Mohamed A, Palmer MB, Wages CA, Zhu X, Garden AS, Rosenthal DI, Frank SJ, Fuller CD. Hounsfield Unit Correction for Dental Implant Materials in Intensity Modulated Proton Therapy of Head and Neck Cancer: A Quality Assurance Benchmark Study. International Journal of Radiation Oncology*Biology*Physics, 90(1/1):S925-S926, 2014. e-Pub 2014.
- Li H, Peter P, Chang JY, Liao Z, Zhang X, Liu W, Li Y, Poenisch F, Mohan R, Frank SJ, Zhu X. Robust Optimization in Intensity Modulated Proton Therapy Reduces Dose Variation Due to Setup Uncertainty and Anatomy Change. International Journal of Radiation Oncology*Biology*Physics 90(1/1):S143, 2014. e-Pub 2014.
- Li H, Zhang X, Li Y, Zhu X. Minimizing Dose Uncertainty for Spot Scanning Proton Therapy of Moving Tumors by Optimization of the Spot Delivery Sequence. International Journal of Radiation Oncology*Biology*Physics 90(1/1):S926, 2014. e-Pub 2014.
- Holliday E, Garden AS, Fuller CD, Phan J, Gunn GB, Rosenthal DI, Beadle BM, Morrison WH, Zolcak-Uzel E, Zhang X, Zhu X, Lewis G, Glisson BS, Hutcheson KA, Weber RS, El-Nagger AK, Hong J, Hung T, Frank SJ. Gastrostomy Tube Rates Decrease by Over 50% in Patients With Nasopharyngeal Cancer Treated With Intensity Modulated Proton Therapy (IMPT): A Case–Control Study. International Journal of Radiation Oncology*Biology*Physics 90(1/1):S528, 2014. e-Pub 2014.
- Lee AK, Gonzalez G, Choi S, Pugh TJ, Mahmood U, Mathai B, Munsell M, Sahoo N, Gillin M, X. The Impact of Hormone Therapy on Long-Term Quality of Life in Men Receiving Proton Therapy for Prostate Cancer. International Journal of Radiation Oncology*Biology*Physics 90(1/1):S713, 2014. e-Pub 2014.
- Pugh TJ, Gonzalez G, Choi S, Mahmood U, Mathai B, Munsell M, Sahoo N, Gillin M, Zhu X, Lee AK. Proton Beam Therapy for Localized Prostate Cancer: A Comparison of Passively Scattered to Intensity Modulated Proton Therapy. International Journal of Radiation Oncology*Biology*Physics 90(1/1):S54-S55, 2014. e-Pub 2014.
- Chang JY, Li H, Zhu R, Liao Z, Lina Z, Liu AL, Zhu Z, Gomez D, Wu R, Gillin M, Zhang X. Clinical Implementation of Intensity Modulated Proton Therapy in Thoracic Malignancies. International Journal of Radiation Oncology*Biology*Physics 90(1/1):S615-S616, 2014. e-Pub 2014.
- Jiang S, Liao L, Li Y, Wang X, Li H, Zhu X, Sahoo N, Gillin M, Hojo Y, Chang J, Liao Z, Grosshans D, Frank S, Zhang X. A Novel Hybrid Planning Approach to Allow More Patients Benefited by the Intensity Modulated Proton Therapy. Med Phys 41(6), 2014. e-Pub 2014.
- Dong L, Zhu X, Unkelbach J, Schulte R. The Status of Intensity Modulated Proton and Ion Therapy. Med. Phys(41):536, 2014. e-Pub 2014.
- Li H, Zhang X, Li Y, Zhu X. Minimizing Dose Uncertainty for Spot Scanning Beam Proton Therapy of Moving Tumor with Optimization of Delivery Sequence(41):551, 2014. e-Pub 2014.
- Matney J, Park P, Court L, Zhu X, Li H, Liu W, Dong L, Mohan R. Reducing the Effect of Respiratory Motion On the Delivered Dose in Proton Therapy Through Proper Field Angle Selection. Med. Phys(41):552, 2014. e-Pub 2014.
- Lou K, Mirkovic D, Sun X, Zhu X, Poenisch F, Grosshans D, Clark J, Shao Y. Intra-Fraction Proton Beam-Range Verification with PET Imaging: Feasibility Studies with Monte Carlo Simulations and Statistical Modeling. Med. Phys(41):174, 2014. e-Pub 2014.
- Liao L, Jiang S, Li Y, Wang X, Li H, Zhu X, Sahoo N, Gillin M, Mahajan A, Grosshans D, Lim G, Zhang X. Robust Intensity Modulated Proton Therapy Plan Can Eliminate Junction Shifts for Craniospinal Irradiation 41:553, 2014. e-Pub 2014.
- Liu W, Liao Z, Schild S, Park P, Li H, Li Y, Li X, Shen J, Anand A, Sahoo N, Dong L, Bues M, Zhu X, Mohan R. Impact of Respiratory Motion On Robustly-Optimized Intensity-Modulated Proton Therapy to Treat Lung Cancers. Med. Phys 241:330, 2014. e-Pub 2014.
- Sahoo N, Zhu X, Zhang X, Poenisch F, Li H, Wu R, Lii M, Umfleet W, Gillin M, Mahajan A, Grosshans D. Analysis of the Impact of Range and Setup Uncertainties On the Dose to Brain Stem and Whole Brain in the Passively Scattered Proton Therapy Plans. Med. Phys 41:340, 2014. e-Pub 2014.
- Stoker J, Summers P, Li X, Gomez D, Sahoo N, Zhu X, Gillin M. Dosimetric Impact of Scan Orientation Relative to Target Motion During Spot Scanning Proton Therapy. Med. Phys 41:253, 2014. e-Pub 2014.
- Li X, Kantor M, Zhu X, Frank S, Sahoo N, Li H. Dosimetric Accuracy of Proton Therapy for Patients with Metal Implants in CT Scans Using Metal Deletion Technique (MDT) Artifacts Reduction. Med. Phys 41:316, 2014. e-Pub 2014.
- Guan F, Bronk L, Kerr M, Titt U, Taleei R, Mirkovic D, Zhu X, Grosshans D, Mohan R. The Effect of Particle Tracking Step Size Limit On Monte Carlo- Computed LET Spectrum of Therapeutic Proton Beams. Med. Phys 41:534, 2014. e-Pub 2014.
- Mackin D, Zhang X, Li Y, Li H, Wu R, Poenisch F, Suzuki K, Kerr M, Holmes C, Zhu X, Sahoo N, Gillin M. Spot-Scanning Proton Therapy Patient-Specific Quality Assurance: Our Methodology and Results from 295 Treatment Plans. Med. Phys 41:429, 2014. e-Pub 2014.
- Frank SJ, Rosenthal DI, Ang K, Sturgis EM, Chambers MS, Gunn GB, Hutcheson KA, Zhu XR, Palmer MB, Garden AS. Gastrostomy Tubes Decrease by Over 50% With Intensity Modulated Proton Therapy. International Journal of Radiation Oncology*Biology*Physics 87(2(1)):S144, 2013. e-Pub 2013.
- Taylor M, Liao Z, Bluett J, Kerr M, Li H, Sahoo N, Gillin M, Zhu X, Zhang X. Improving Passive Scattering Proton Therapy Plan Quality by Optimizing Compensator Parameters. Medical Physics 40(6):416-417, 2013. e-Pub 2013.
- Li H, Park P, Zhang X, Liu W, Liao Z, Dong L, Gillin M, Zhu X. Quantification and Prediction of Dose Variation in Scanning Beam Proton Therapy From Setup and Anatomical Change for Single-Field, Multi-Field, and Robustly Optimized Plans. Medical Physics 40(6):420, 2013. e-Pub 2013.
- Shao Y, Sun X, Lou K, Zhu X, Mirkovic D, Poenisch F, Grosshans D. In-Beam PET Imaging with Depth-Of-Interaction Measurement for Accurate Proton Beam-Range Verification. Medical Physics 40(6):503, 2013. e-Pub 2013.
- Mackin D, Zhang X, Li Y, Taylor M, Kerr M, Holmes C, Sahoo N, Poenisch F, Li H, Lii M, Amos R, Wu R, Suzuki K, Gillin M, Zhu X. Improving Spot Scanning proton Therapy Patient-Specific Quality Assurance Through Early Application of Second-Class Dose Calculation Software. Medical Physics 40(6):240, 2013. e-Pub 2013.
- Guan F, Mohan R, Dihn J, Kerr M, Perles L, Mirkovic D, Titt U, Zhu X, Gillin M, Meyn R, Lin S, Grosshans D. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. Medical Physics 40(6):552, 2013. e-Pub 2013.
- Liu W, Mohan R, Zhu X, Grosshans D. Robust Optimization in Intensity-Modulated Proton Therapy for Base-of-Skull Cancers. Medical Physics 40(6):546-547, 2013. e-Pub 2013.
- Park P, Cheung J, Zhu X, Liu W, Sahoo N, Court L, Mohan R, Li H, Dong L. A Statistical Approach to Quantification and Visualization of Setup and Range Uncertainties for Proton Plan Verification. Medical Physics 40(6):528, 2013. e-Pub 2013.
- Sahoo N, Dhanesar S, Poenisch F, Lii M, Li H, Zhang X, Amos R, Wu R, Gillin M, Zhu X. Application of a Semi-Empirica Formula to Determine Spread Out Bragg Peak Factors and Range Shifter Factors From Measured Depth Dose Curves for Passively Scattered Proton Beams. Medical Physics 40(6):203-204, 2013. e-Pub 2013.
- Kerr M, Dhanesar S, Guan F, Taylor M, Zhu X, Gillin M, Amos R, Sahoo N. Relative Proton Stopping Power Ratio Database for Common Dosimetry Phantom Materials. Medical Physics 40(6):214, 2013. e-Pub 2013.
- Cheung J, Dong L, Park P, Zhu X, Kudchadker R, Frank S, Palmer M, Liu W, Court L. Prediction of Sensitivity of IMPT Plans to Anatomical Change Due to Plan Complexity. Medical Physics 40(6):363, 2013. e-Pub 2013.
- Park P, Matney J, Mohan R, Zhu X, Dong L, Li H, Cheung J, Sahoo N, Yang J, Poenisch F, Liu W. Perturbation of Tissue Density Is An Important Metric To Be Considered When Planning for Respiratory Motion Management for Lung Proton Therapy. Medical Physics 40(6):397, 2013. e-Pub 2013.
- Li H, Park P, Liu W, Matney J, Liao Z, Zhang X, Zhu X. Respiratory Motion-Induced Dose Uncertainty in Step-And-Shoot IMRT. Medical Physics 40(6):288, 2013. e-Pub 2013.
- Dhanesar S, Sahoo N, Kerr M, Taylor M, Summers P, Alvarez P, Wu R, Poensich F, Zhu X, Gillin M. Intensity Modulated Proton Therapy Plans with Multiple Fields for Prostate Cancer. Medical Physics 40(6):297, 2013. e-Pub 2013.
- Cheung J, Court L, Park P, Zhu X, Frank S, Kudchadker R, Dong L. Evaluation of Various Spot MU Correction Methods for Range Adaptive Scanning-Beam Proton Planning. Medical Physics 40(6):359, 2013. e-Pub 2013.
- Stoker J, Amos R, Li Y, Liu W, Park P, Sahoo N, Zhang X, Zhu X, Gillin M. Comparison of Discrete Spot Scanning and Passive Scattering Craniospinal Proton Irradiation. Medical Physics 40(6):365, 2013. e-Pub 2013.
- Hojo Y, Gillin M, Suzuki K, Wu R, Zhu X. 3D Collision for Proton Therapy Treatment Planning. Medical Physics 40(6):262, 2013. e-Pub 2013.
- Liu W, Mohan R, Zhang X, Zhu XR, Frank, SJ. Effectiveness of Robust Optimization in Oropharynx IMPT Planning. International Journal of Radiation Oncology*Biology*Physics, 87(2):S443, 2013. e-Pub 2013.
- Dhanesar S, Zhang X, Taylor M, Li Y, Li H, Bluett J, Gillin M, Liao Z, Zhu X, Sahoo N. Study of Robustness of Passive Scattering Proton Therapy Plans for Targets in Lung and. International Journal of Radiation Oncology*Biology*Physics 87(2):S744, 2013. e-Pub 2013.
- Quan E, Liu W, Li Y, Zhang X, Zhu XR, Mohan R, and Wu R. Improvement in Robustness and Delivery Efficiency of Intensity‐Modulated Proton Therapy Using Single‐Field Optimization with Energy Absorber. Med Phys 39:3965, 2012. e-Pub 2012.
- Li X, Wang X, Li Y, Zhu X, Sahoo N, Gillin M, and Zhang X. Deliverable Optimization Incorporating Monitor Unit Constraints for Intensity Modulated Proton Therapy Treatment Planning. Med Phys 39:3982, 2012. e-Pub 2012.
- Li Y M Lii M, Li H, Taylor M, Li X, Zhu X, Sahoo N, Gillin M, and Zhang X. Independent Dose Verification System for Spot Scanning Proton Therapy. Med Phys 39:3714, 2012. e-Pub 2012.
- Anand A, Kerns J, Sahoo N, Zhu XR, and Gillin M. A Technique to Determine the Gantry Laser and the Proton Pencil Beam Coincidence Using Computer Radiography Detector for Routine Quality Checks. Med Phys 39:3886, 2012. e-Pub 2012.
- Liu W, Zhu XR, Li X, Li Y, Zhang X, Frank S, and Mohan R. Comparison of PTV+PRV-Based Optimization and Robust Optimization in Intensity-Modulated Proton Therapy. Med Phys 39:3849, 2012. e-Pub 2012.
- Tsunashima Y, Sahoo N, Sakae T, Poenisch F, Umezawa M, Briere T, Zhu XR, Mohan R, Dong L. Achievability and Optimization of Synchrotron-Based Respiratory Gated Spot Scanning Proton Beam Delivery. Med Phys 39:3795, 2012. e-Pub 2012.
- Zhu XR, Li H, Li Y, Lii M, Taylor M, Zhang X, Poenisch F, Gillin M Frank S, and Sahoo N. Development of An Efficient and Effective Patient Specific QA Program for IMPT. Med Phys 39:3600, 2012. e-Pub 2012.
- Chen Y, Zhang L, Court L, Liao Z, Zhu XR, Mohan R, and Dong L. Comparison of Planned Dose Distribution Vs. Delivered Dose Distribution for Both IMRT and Proton Therapy Using Weekly Repeat 4DCT Data Sets. Med Phys 39:3795, 2012. e-Pub 2012.
- Cao W, Li X, Lim G, Li Y, Zhu XR, and Zhang X. An Investigation of the Impact of Spot Spacing On Plan Quality Using IMPT Optimization Incorporating Deliverable Monitor Unit Constraints. Med Phys 39:5248, 2012. e-Pub 2012.
- Song X, Sahoo N, Wu R, Taylor M, Georges R, Zhu XR, Summers P, and Gillin M. Dosimetry of Double Scattered Proton Beam Fields Used for Cranio‐Spinal Irradiation. Med Phys 39:3770, 2012. e-Pub 2012.
- Winey B, Zhu XR, Both S, Adams J. Proton Treatment Planning Issues. Med Phys 39:3871, 2012. e-Pub 2012.
- Park P, Cheung J, Chen Y, Zhu X, Sahoo N, Court L, Mohan R, and Dong L. Statistical Assessment of Plan Robustness Under Uncertainties: IMRT Vs. Proton Therapy. Med Phys 39:3985, 2012. e-Pub 2012.
- Cheung, Park P, Zhu X, Frank S, Court L, Kudchadker R, and Dong L. Feasibility of Online Range Adaptive Spot Scanning Proton Therapy. Med Phys 39:3998, 2012. e-Pub 2012.
- Liu W, Frank S, Li X, Li Y, Zhang X, Zhu XR, and Mohan R. Effectiveness of Robust Optimization in Head and Neck IMPT Dose Distributions. Med Phys 39:3835, 2012. e-Pub 2012.
- Li H, Zhang L Balter P, Dong L, Gillin M, and Zhu XR. Evaluation of Effectiveness of Immobilization Devices for Radiation Therapy with Repeated CBCT Studies. Med Phys 39:3658, 2012. e-Pub 2012.
- Dhanesar S, Sahoo N, Taylor M, Song X, Poenisch F, Summers P, Li H, Zhu XR, and Gillin M. Evaluation of Zebra Multi‐Layer Ionization Chamber System for Patient Treatment Field and Machine QA for Spot Scanning and Passive Scattering Proton Beams 39:3613, 2012. e-Pub 2012.
- Li H, Li Y, Lii M, Liu W, Li X, Sahoo N, Gillin M, and Zhu XR. Automatic Dose Verification for Spot Scanning Proton Therapy Using Recorded Spot Positions and MUs. Int J Radiat Oncol Biol Phys 84:S839, 2012. e-Pub 2012.
- Song X, Zhang L, Park PC, Zhu XR, Sahoo N, Gillin MT, and Dong L. Application of Beam-specific PTV in Proton Therapy Treatment Planning. Int J Radiat Oncol Biol Phys 84:S848-S849, 2012. e-Pub 2012.
- Yoshikazu T, Sahoo N Poenisch F, Umezawa M, Briere TM, Zhu XR, Mohan R, and Dong L. Experimental Evaluation of the Interplay Effect and Motion Management by Respiratory Gating in Synchrotron-based Spot Scanning Proton Beam Delivery. Int J Radiat Oncol Biol Phys 84:S54-S55, 2012. e-Pub 2012.
- Anand A, Tung S, Tailor R, Morrison WH, and Zhu XR. Dosimetric Evaluation of Tungsten Eye-Shield in 9, 12, and 16 MeV Electron Beams Using EBT2 Gafchromic Films. Int J Radiat Oncol Biol Phys 84:S873, 2012. e-Pub 2012.
- Yeh BK, Zhu XR, Palmer MB, Amin MV, Georges RH, Nuanjing J, Garcia JA, and Frank SJ. Intensity Modulated Proton Therapy Is Dosimetrically Superior to Intensity Modulated Radiation Therapy for Head-and-Neck Cancers. Int J Radiat Oncol Biol Phys 84:S840, 2012. e-Pub 2012.
- Yeh BK, Georges RH, Zhu XR, Palmer MB, Amin MV, Cheung JP, Dong L, Nuanjing J, Garcia JA, and Frank SJ. Adaptive Replanning is Required During Intensity Modulated Proton Therapy For Head-and-Neck Cancers. Int J Radiat Oncol Biol Phys 84:S56-S57, 2012. e-Pub 2012.
- Sahoo N, Dhanesar SK, Song X, Poenisch F, Lii M, Li H, Amos R, Wu R, Gillin MT, and Zhu XR. Determination of Spread Out Bragg Peak Factors and Range Shifter Factors From Measured Depth Dose Curves for Passively Scattered Proton Beams. Int J Radiat Oncol Biol Phys 84:S849, 2012. e-Pub 2012.
- Liu W, Frank S, Zhu XR, Li X, Li Y, R Mohan R. Conventional PTV-based Optimization Lacks Robustness for IMPT Head and Neck (H&N) Planning. Int J Radiat Oncol Biol Phys 84:S838, 2012. e-Pub 2012.
- Palmer M, Mok H, Ciura K, Georges R, Nguyen B, Crawford C, Beddar S, Zhu R, Crane C, and Das P. Dose Reduction to Small Bowel and Other Relevant Structures in Rectal Carcinoma With Proton Therapy. Int J Radiat Oncol Biol Phys 84:S846, 2012. e-Pub 2012.
- Mahajan A, Amin MV, Grosshans DR, McGovern SL, McAleer M, Nguyen B, Wages CA, Zhu XR, Brown PD. Evaluation of Scanning Beam Proton Therapy for Medulloblastoma Boost Treatment. Int J Radiat Oncol Biol Phys 84:S846, 2012. e-Pub 2012.
- Frank SJ, Cox JD, Gillin M, Rosenthal DI, Garden AS, Ang K, Mohan R, Palmer MB, Amin M, and Zhu XR. Intensity Modulated Proton Therapy for Head-and-Neck Cancer: The First Clinical Experience. Int J Radiat Oncol Biol Phys 84:S475-S476, 2012. e-Pub 2012.
- Palmer M, Jones T, Waddell M, Varghese S, Zhang Y, Amin M, Yeh NK, Zhu R, Dong L, and SJ Frank SJ. The Optimal Timing for Off-line Adaptive Planning for Bilateral Head-and-Neck IMPT is Week 4. Int J Radiat Oncol Biol Phys 84:S479-S480, 2012. e-Pub 2012.
- Dhanesar S, Sahoo N, Grosshans D, McAleer M, Wages C, Crawford C, Palmer M, Woo S, Mahajan A, and Zhu XR. Comparison of Skin Doses in Spot Scanning and Passive Scattering Proton Therapy Treatment Plans for Pediatric Patients With Spinal Ependymomas. Int J Radiat Oncol Biol Phys 84:S836, 2012. e-Pub 2012.
- Egashira Y, Nishijima Y, Tsunashima Y, Mohan R, Zhu XR, Komaki R, Cox JD, Uesaka M, and Gillin MT. Experimental Evaluation of the Interplay Effect of Scanning Proton Beam for Small Moving Target in Heterogeneity Using a 4-dimensional Phantom. Int J Radiat Oncol Biol Phys 84:S842, 2012. e-Pub 2012.
- Ciangaru G, Sahoo N, Sawakuchi G, Zhu XR, Mohan R, and Gillin M. Feasibility Study of Radiobiological Effectiveness‐Based Treatment Plan Optimization for Spot‐Scanned Proton Therapy Beams. Med Phys 38:3638, 2011. e-Pub 2011.
- Grosshans D, Curtis W, Zhu XR, Palmer M, Amsbaugh M, Kumar A, and Wang J. MR Diffusion Tensor Imaging Application in Assessing Cognitive Impairment in Children After Cranial Proton Irradiation. Med Phys 38:3459, 2011. e-Pub 2011.
- Blatnica A, Ibbott G, Zhu XR, P Balter P, R White R, and Followill D. Modification and Implementation of the RPC Heterogeneous Thorax Phantom for Verification of Proton Therapy Treatment Procedures 38:3525, 2011. e-Pub 2011.
- Tsunashima Y, Poenisch F, Li H, Zhu XR, Balter P, Umezawa M, Sahoo N, R Mohan R, and Dong L. Dosimetric Characterization of Motion Effect in Delivering Uniform Target Dose Distribution Using Scanning Proton Beams. Med Phys 38:3779, 2011. e-Pub 2011.
- Park P, Zhu XR, Sahoo N, Lee A, Zhang L, Cheung J, and Dong L. Incorporating Beam‐Specific Target Volumes Into Beam Angle Selection in Proton Therapy. Med Phys 38:3739, 2011. e-Pub 2011.
- Sahoo N, Anand A, Martin C, Ciangaru G, Poenisch F, Li H, Gillin M, and Zhu XR. Study of the Effect of the Optical Density to Dose Conversion Calibration Curves on the Measurement of Transverse Lateral Dose Profiles of Proton Beams Using Kodak XV Films. Med Phys 38:3519, 2011. e-Pub 2011.
- Cheung J, Park P, Zhu XR, Court LE, Frank SJ, Kudchadker R, and Dong L. Comparison of Dosimetric Benefit of Online Dose‐Guided Alignment versus Anatomy‐Guided Alignment for Proton Therapy. Med Phys 38:3854, 2011. e-Pub 2011.
- Anand A, Sahoo N, Zhu XR, Titt U, Sawakuchi G, Li Y, Poenisch F, Amos R, Suzuki K, Ciangaru G, Mohan R, and Gillin M. Scanned Proton Pencil Beam's Lateral Profile Library to Describe the Spot Dose Characteristics. Med Phys 38:3855, 2011. e-Pub 2011.
- Grant R, Ibbott G, Zhu X R, Carroll M, Adamovics J, Oldham M, and Followill D. Investigation of PRESAGE® Dosimeters for Proton Therapy. Med Phys 38:3571, 2011. e-Pub 2011.
- Yang M, Zhu XR, Clayton J, Virshup G, Mohan R, and Dong L. Comprehensive Uncertainty Analysis of Proton Stopping‐Power‐Ratio Estimation Using a KV‐MV Dual Energy CT Scanner (DECT) for Margin Reduction. Med Phys 38:3702, 2011. e-Pub 2011.
- Zhu XR, Grosshans D, Lee A, Choi S, Mahajan A, Chang E, Pugh T, Wu R, AMIN M, Palmer M, Taylor M, Gillin M, and Sahoo N. Spot Scanning Proton Therapy: Single Field Simultaneous Integrated Boost. Med Phys 38:3602, 2011. e-Pub 2011.
- Wootton L, Zhu XR, Kudchadker R, Sharma R, Choi B, Taylor M, Dong L, Johnson J, Nguyen Q, Choi S, and Lee A. Comparison of Fiducial and Bony‐Anatomy Based Alignment for Prostate Localization in Proton Therapy. Med Phys 38:3609, 2011. e-Pub 2011.
- Huang J, Newhauser W, Zhu X, Lee A, and Kudchadker R. Investigation of Dose Perturbations and Radiographic Visibility of Potential Fiducials for Proton Radiation Therapy of the Prostate. Med Phys 38:3778, 2011. e-Pub 2011.
- Grant R, Ibbott G, X Zhu XR, Adamovics J, M Oldham M, Followill D. Investigation of Proton Beam Dose Distributions with 3D Dosimetry. Int J Radiat Oncol Biol Phys 81:S885-S886, 2011. e-Pub 2011.
- Poenisch F, Sahoo N, Taylor MB, Grosshans DR, Frank SJ, Lii M, Wu R, Zhang X, M Gillin M, Zhu XR. Verification of Multi-field Optimized Proton Pencil Beam Treatment Plans. Int J Radiat Oncol Biol Phys 81:S879, 2011. e-Pub 2011.
- Choi S, Amin M, Palmer MB, Zhu XR, Nguyen Q, Pugh TJ, Kuban DA, Lee AK. Comparison of Intensity Modulated Proton Therapy (IMPT) to Passively Scattered Proton Therapy (PSPT) in the Treatment of Prostate Cancer. Int J Radiat Oncol Biol Phys 81:S154-S155, 2011. e-Pub 2011.
- Gomez DR, Amin MV, Crawford C, Welsh J Chang JY, Zhu XR, Liao Z, Komaki KU, Cox JD, Mohan R. A Comparison Of Strategies To Account For Bowel Filling In Patients Treated With Proton Therapy For Locally Advanced Distal Esophageal Cancer: A Planning Study. Int J Radiat Oncol Biol Phys 81:S883, 2011. e-Pub 2011.
- Grant R, Ibbott G, Riley B, Sahoo N, Tucker S, Zhu X, and Followill D. Effect of Film Orientation on Proton Beam Dosimetry. Med Phys 37:3296, 2010. e-Pub 2010.
- Yang M, Zhu X, Mohan R, and Dong L. Does KV‐MV Dual‐Energy Computed Tomography Have an Advantage in Measuring Proton Stopping Power Ratio in Patients?. Med Phys 37:3365, 2010. e-Pub 2010.
- Zhu X, Sahoo N, Zhang X, Robertson D, Li H, Choi S, Lee A, and Gillin M. The Impact of Monitor Unit Constraints on Plan Quality of IMPT Planning Using Single‐Field Optimization. Med Phys 37:3365, 2010. e-Pub 2010.
- Ding X, Sahoo N, Song X, Zhu X, Lii M, and Gillin M. GEANT4 Monte‐Carlo Simulation of Dosimetry Parameters of the Passively Scattered Beam Lines at the Proton Therapy Center in Houston. Med Phys 37:3273, 2010. e-Pub 2010.
- Pan X, Zhang X, Li Y, Li X, Chang J, Zhu XR, and Mohan R. Inverse Beam Angle Optimization in IMRT for Lung Cancer Patients. Med Phys 37:3341, 2010. e-Pub 2010.
- Park P, Zhu XR, Melancon A, Tsunashima Y, Shaoo N, Dong L. A Novel Beam-Specific PTV Design to Account for Setup Error and Range Uncertainties for Scanning Beam Proton Therapy 37:3409, 2010. e-Pub 2010.
- Yu Z, Bluett J, Zhang Y, X Zhu X, Lii M, Mohan R, and Dong L. Experimental Characterization of the Low‐Dose Envelope of Spot Scanning Proton Beams. Med Phys 37:3294, 2010. e-Pub 2010.
- Li H, Delclos M, Briere T, Beddar S, Das P, Krishnan S, Zhu XR, and Crane C. The Impact of Free Breathing versus Average 4D CT Image Data on External Beam Radiotherapy Planning for Liver. Med Phys 37:3322, 2010. e-Pub 2010.
- Park P, Zhu X, Melancon A, Tsunashima Y, Sahoo N, and Dong L. A Novel Beam‐Specific PTV Design to Account for Setup Error and Range Uncertainties for Scanning Beam Proton Therapy. Med Phys 37:3409, 2010. e-Pub 2010.
- Poenisch F, Sahoo N, Martin C, Zhu XR, and Gillin M. Feasibility of Using a Multi‐Array Ion Chamber Detector for Daily QA in Protons Therapy. Med Phys 37:3364, 2010. e-Pub 2010.
- Li H, Dong L, Zhang L, Yang JN, Gillin MT, Mohan R, and Zhu XR. Surface Based Distance Measures with Treatment Technique Specific Gradient Factor for IMRT QA Tolerances Determination. Med Phys 37:3399, 2010. e-Pub 2010.
- Anand A, Sahoo N, Zhu XR, Sawakuchi G, Poenisch F, Amos R, Suzuki K, Mohan R, and Gillin M. A Technique to Determine the Integral Depth Dose of Proton Pencil Beam Spots. Med Phys 37:3363, 2010. e-Pub 2010.
- Pollard J, Poenisch F, Sahoo N, Zhu XR, and Gillin M. Verification of the Accuracy of the Proton Range Compensator Scatter Factor and Dose within Inhomogeneity Calculations Using the Eclipse Treatment Planning System. Med Phys 37:3260, 2010. e-Pub 2010.
- Melancon A, Lee A, Kudchadker R, Titt U, Beddar S, Zhu XR, and Dong L. Range Adaptive Proton Therapy for Prostate Cancer. Med Phys 37:3332, 2010. e-Pub 2010.
- Sahoo N, Ciangaru G, Sawakuchi G, Anand A, Poenisch F, Suzuki K, Mohan R, Gillin M, and Zhu XR. Study of the Magnitude of Detector Size Effect in the Measured Lateral Profiles of Proton Pencil Beam Spots. Med Phys 37:3293, 2010. e-Pub 2010.
- Sahoo N, Song X, Zhu XR, Gillin MT. A Novel Procedure to Account for the Changes in the Position of High or Low Density Objects in Treatment Planning for Spot Scanned Proton Beam Therapy. Int J Radiat Onc Biol Phys 78:S134-S135, 2010. e-Pub 2010.
- Giebeler, Zhu XR, Starkschall G, Balter P, Titt P, Tucker S, and Newhauser W. Estimation of Uncertainty for the Patient and Compensator Scatter Correction Factor in Proton Therapy D/MU Calculations. Med Phys 36:2668-2669, 2009. e-Pub 2009.
- Wang X, N Sahoo N, Zhu XR, Ding X, Arjomandy B, Ciangaru G, and Gillin M. Study of Field Size Factors for Passively Scattered Proton Therapy Beams. Med Phys 36:2582, 2009. e-Pub 2009.
- Li H, Lee A, Zhu X, and Kudchadker R. The Effect of Treatment Couch Attenuation On Radiation Dose for Megavoltage Photon Beams. Med Phys 36:2580, 2009. e-Pub 2009.
- Li H, Zhu XR, Ciangaru G, Sahoo N, Suzuki K, Lee A, and Gillin M. Spot Position Uncertainty of Scanning Proton Pencil Beam 36:2587, 2009. e-Pub 2009.
- Both S, Zhu T, Finlay J, Zhu XR, Slopema R, Dolney D, McDonough J. An Independent Program for MU Check of Modulated Scanning Beam for IMPT. Med Phys 36:2565, 2009. e-Pub 2009.
- Robertson D, Zhang X, Y Li Y, Lee A, Gillin M, Zhu XR, and Mohan R. Optimizing Spot Spacing and Margin for Intensity-Modualted Proton Therapy Planning. Med Phys 36:2554, 2009. e-Pub 2009.
- Arjomandy B, Sahoo N, Cox J, Lee A, Zhu X, and Gillin M. Surface Doses Comparison for Spot Scanned and Passively Scattered Proton Therapy Beams. Med Phys 36:2544, 2009. e-Pub 2009.
- Sahoo N, Martin C, Zhu XR, Ding X, Arjomandy B, Ciangaru G, and Gillin G. Study of Differences in Lateral Penumbra Widths of Passively Scattered and Spot Scanned Proton Therapy Beams. Med Phys 36:2585, 2009. e-Pub 2009.
- Grant R, Ibbott G, Sahoo N, Tucker S, Zhu XR, and Followill D. Evaluation of An Anthropomorphic Pelvis Phantom for Proton Therapy. Med Phys 36:2607, 2009. e-Pub 2009.
- Zhu X, Sahoo N, Sawakuchi G, Lii M, Ciangaru G, Bues M, Pan X, Zhang X, Ding X, Titt U, Arjomandy B, Suzuki K, Mohan R, and Gillin M. Configuration and Validation of a Double Gaussian Dose Model for Scanning Proton Beams. Med Phys 36:2667, 2009. e-Pub 2009.
- Sawakuchi G, Titt U, Ciangaru G, Mirkovic D, Zhu XR, and Mohan R. The Causes of the Lateral Envelop of Low Doses in Scanning Proton Beamlets. Med Phys 36:2620, 2009. e-Pub 2009.
- Zhu XR, Titt U, Bues M, Sahoo N, Ciangaru G, Sawakuchi G, Poenisch F, Lii M, Zhang X, Li Y, Arjomandy B, Suzuki K, Mohan R, and Gillin M. Configuration and Validation of a Single Gaussian Dose Model for Scanning Proton Beams. Med Phys 36:2666, 2009. e-Pub 2009.
- Sawakuchi G, Titt U, Mirkovic D, Zhu XR, Sahoo N, Bues M, Ciangaru G, Poenisch P, Suzuki K, Arjomandy B, Gillin M, and Mohan R. Validation of An MCNPX Monte Carlo Model of a Discrete-Spot Scanning Beam Nozzle and Evaluation of the Beamlet Lateral Envelope of Low Doses. Med Phys 36:2782-2783, 2009. e-Pub 2009.
- Ciangaru G, Sahoo N, Zhu XR, Sawakuchi G, and Gillin M. Algorithm for Accurate Computation of Doses From Large-Angle Scattering of Scanned Proton Pencil Beams. Med Phys 36:2783, 2009. e-Pub 2009.
- Matney J, Vedam S, Dong L, Amos A, Zhu X, Balter P, and Mohan R. Is Average CT a Good Estimate of Mid-Ventilation Position of Surrounding Normal Structures for Proton Therapy Treatment Planning of Lung Tumors?. Med Phys 36:2710, 2009. e-Pub 2009.
- Yang M, Virshup G, Clayton J, Zhu XR, Mohan R, and Dong L. In Vivo Measurement of Proton Stopping Power Ratios in Patients Using Dual Energy Computed Tomography. Med Phys 36:2757, 2009. e-Pub 2009.
- Meyer J, Bluett J, Li Y, Zhang X, Chi L, Nguyen N, Zhu X, Amos R, Lee A, Woo S. Impact of Range Uncertainty on Proton Radiotherapy Dosimetry: Generating "Worst Case Scenarios" for Doses to Critical Structures. Int J Radiat Oncol Biol Phys 74:S700, 2009. e-Pub 2009.
- Sahoo N, Zhu XR, Arjomandy B, Ciangaru G, Ding X, and Gillin M. Feasibility Study of a Set of Quality Assurance Checks for Spot Scanning Proton Therapy Beams by using a 2-D Ion Chamber Array. Int J Radiat Oncol Biol Phys 74:S698-S699, 2009. e-Pub 2009.
- Li H, Sahoo N, Dong L, Gillin M, Mohan R, and Zhu XR. CT Artifacts of High-Density Materials in Proton Radiation Therapy. Med Phys 35:2693, 2008. e-Pub 2008.
- Wu R, Amos R, Sahoo N, Kornguth D, Bluett J, Gillin M, Zhu XR. Effect of CT Truncation Artifacts to Proton Dose Calculation. Med Phys 35:2697, 2008. e-Pub 2008.
- Lindsay P, Yildirim G, A Garden A, Zhang L, Yu Z, Zhang Y, X Zhu XR, Theriot L, Ahamad A, and Dong L. Dosimetric Impact of Anatomy Variations and Benefits of Mid-Course Replanning for Head and Neck IMRT. Med Phys 35:2737, 2008. e-Pub 2008.
- Ding X, Sahoo N, Zhu XR, Yang J, Arjomandy B, Lii M, Titt U, Mohan R, Smith A, and Gillin M. Validation Study of the GEANT 4 Monte-Carlo Simulation of the Proton Dose Distribution From Passively Scattered Proton Beam Nozzles at the Proton Therapy Center at Houston. Med Phys 35:2799, 2008. e-Pub 2008.
- Gillin M, X Zhu XR, Sahoo N, Lii M, and Arjomandy B. Time and Manpower Requirements for Clinical Commissioning of the Passively Scattered Proton Beams at PTC-H. Med Phys 35:2980, 2008. e-Pub 2008.
- Li H, Liu R, Wu R, Sahoo N, Mohan R, Gillin M, and Zhu XR. Effect of CT Calibration Phantom Size On the Range in Proton Radiation Therapy. Med Phys 35:2955, 2008. e-Pub 2008.
- Yang M, Virshup G, Mohan R, Shaw C, Zhu XR, and Dong L. Improving Accuracy of Electron Density Measurement in the Presence of Metallic Implants Using Orthovoltage Computed Tomography. Med Phys 35:2969, 2008. e-Pub 2008.
- Arjomandy B, Sahoo N, Zhu X, Zullo J, Wu R, Zhu M, Ding X, and Gillin M. An Overview of Comprehensive Proton Machine Quality Assurance at the University of Texas M.D. Anderson Cancer Center. Med Phys 35:2995, 2008. e-Pub 2008.
- Giebeler A, Fontenot J, Balter P, Ciangaru G, Zhu XR, and Newhauser W. Dose Perturbations Caused by Implanted Helical Gold Markers Used in Patients Receiving Proton Radiation Therapy for Prostate Cancer. Med Phys 35:2888, 2008. e-Pub 2008.
- Ciangaru G, Sahoo N, Arjomandy B, Zhu XR, and Gillin M. Effect of Titanium Implants On Therapeutic Proton Dose Delivered to Patients. Med Phys 35:2782-2783, 2008. e-Pub 2008.
- Sahoo N, Zhu XR, Lii M, Amos R, Arjomandy B, Wu R, and Gillin M. Study of Dose Distribution in Passively Scattered Proton Beams for Small Field Sizes. Med Phys 35:2491, 2008. e-Pub 2008.
- Arjomandy B, Sahoo N, Gillin M, and Zhu XR. Use of a Two-Dimensional Ionization Chamber Array for Proton Therapy Quality Assurance Checks. Med Phys 35:2502, 2008. e-Pub 2008.
- Gillin M, Zhu XR, Sahoo N, Bues N, Ciangaru N, Arjomandy B, and Poenisch F. Dosimetry Characteristics of the Discrete Spot Scanning Proton Beam at PTCH. Med Phys 35:2746, 2008. e-Pub 2008.
- Lee AK, Kudchadker R, Choi B, Choi S, Bluett J, Zhu R, Dong L. The Effectiveness of Rectal Balloon and Orthogonal Imaging for Proton Therapy of Prostate Cancer. Int J Radiat Oncol Biol Phys 70:S553-554, 2008. e-Pub 2008.
- Titt U, Sahoo N, Zhu XR, Ding X, Zheng Y, Gillin M, and Mohan R. Validation of the Monte Carlo Model of the passive scattering nozzles at the Proton Therapy Center of Houston. Med Phys 34:2503, 2007. e-Pub 2007.
- Arjomandy B, Sahoo N, Gillin M, and Zhu XR. Use of a two-dimensional ionization chamber array for proton therapy quality assurance checks. Med Phys 34:2502, 2007. e-Pub 2007.
- Sahoo N, Zhu XR, Lii M, Amos R, Arjomandy B, Wu R, Gillin M. Study of dose distribution in passively scattering beams for small field sizes. Med Phys 34:2491, 2007. e-Pub 2007.
- Bivens W, Ibbott G, Maryanski M, Heard M, Followill D, and Zhu XR. Linear energy transfer (LET) dependence of BANG® polymer gel dosimeters in proton beam. Med Phys 34:2467, 2007. e-Pub 2007.
- Wu R, Zhang X, Amos R, Prado K, Lii M, Gillin M, and Zhu XR. Evaluation of Titanium metal imaging artifacts on proton dose calculation. Med Phys 34:2452, 2007. e-Pub 2007.
- Lindsay P, Briere T, Balter P, Sadagopan R, Starkschall G, Zhu XR, and Beddar S. Effect of respiratory gating on the dose distributions of dynamic wedge and IMRT treatment fields. Med Phys 34:2446, 2007. e-Pub 2007.
- Liengsawwangwong P, Ding X, Arjomandy B, Lii M, Sahoo N, Amos R, Gillim M, and Zhu XR. Dosimetric characterization of a 2D diode array detector in passive scattering proton beams. Med Phys 34:2440, 2007. e-Pub 2007.
- Zullo J, Kudchadker R, Lindsay P, Zhu XR, and Gillin M. Dose measurement accuracy of TLD-100 in the Bragg peak region of a therapeutic proton beam. Med Phys 34:2439, 2007. e-Pub 2007.
- Lindsay P, Choi B, Bucci M, Zhang L, Dong L, Kudchadker R, Zhu XR, and Balter P. Comparison of image registration tools used for daily kV imaging-based patient setup. Med Phys 34:2375, 2007. e-Pub 2007.
- Newhauser W, Fonteno J, Zheng Y, Taddei P, Mirkovic, Titt, U, Zhu XR, Sahoo N, Schaffner B, Langenegger A, Koch N, Zhang X, and Mohan R. A Monte Carlo based dose engine for proton radiotherapy treatment planning”, Med. Phys. Med Phys 34:2401, 2007. e-Pub 2007.
- Mohan R, Zhang X, Titt U, Zhu XR, and Dong L. Reducing uncertainties in proton therapy – Achieving “What you see is what you get”. Med Phys 34:2552, 2007. e-Pub 2007.
- Li H, Mohan R, Zhu XR. X-ray scatter in a clinical CBCT system. Med Phys 34:2371, 2007. e-Pub 2007.
- Li H, Mohan R, Zhu XR. Scatter kernel estimation and correction with edge-spread-function method for CBCT imaging. Med Phys 34:2328, 2007. e-Pub 2007.
- Sahoo N, Zhu XR, Zhu M, Amos R, Kudchadker R, Johnson J, Arjomandy B, Lii M, Wu R, and Gillin MT. Analysis of the Accuracy of a Monitor Unit Calculation Procedure for Passively Scattered Proton Therapy Beams. Int J Radiat Oncol Biol Phys 69:S689-690, 2007. e-Pub 2007.
- Cox JD, Chang JY, Liao Z, Bucci MK, McAleer MF, Wei X, Allen PK, Cai H, Gillin M, Zhu XR. Acute Esophageal Reactions from Proton Beam Therapy and Concurrent Chemotherapy for Non-Small Cell Lung Cancer (NSCLC): Reduction in Incidence and Severity Despite Higher Doses. Int J Radiat Oncol Biol Phys 69:S485, 2007. e-Pub 2007.
- Lindsay PE, Zhu XR, Zhang L, Wu R, Kudchadker R, Salehpour R, Liu R, Mohan R, Gillin MD, Dong L. Effect of measured cone-beam CT density calibration on dose calculations. Med Phys 33:2286, 2006. e-Pub 2006.
- Liengsawangwong P, Kudchadker R, Wu R, Session R, Diel T, Aleman G, Dong L, Gillin MT, Zhu XR. Mechanical, radiation and imaging isocenter quantification on four Varian On-Board Imager Clinacs. Med Phys 33:2283, 2006. e-Pub 2006.
- Kudchadker R, Zhu XR, Zhang L, Lee A, Mohan R, Gillin MT, Dong L. Implementation of On-Board Imager for daily Image-Guided Radiation Therapy in a multi vendor environment. Med Phys 33:2038, 2006. e-Pub 2006.
- Zhang L, Dong L, Zhu XR, Garden A, Ahamad A, Ang K, Mohan R. Deformable image registration in cone-beam CT images for image-guided adaptive radiotherapy. Med Phys 33:1995, 2006. e-Pub 2006.
- Titt U, Poenisch F, Kry S, Zhu XR, Mohan R, Vassiliev O. Monte Carlo Simulation of Backscatter in a Flattening Filter Free Clinac. Med Phys 33:2123, 2006. e-Pub 2006.
- Zhu XR, Zhang L, Kudchadker R, Wu R, Balter P, Mohan R, Gillin M, Dong L. Clinical implementation of cone-beam CT for image-guided radiation therapy. Med Phys 33:2268, 2006. e-Pub 2006.
- Zhang Y, Zhang L, Zhu XR, Chambers M, Dong L. Reducing metal artifacts in Cone-beam CT by tracking and eliminating metal shadows in raw projection data. Med Phys 33:2288, 2006. e-Pub 2006.
- Newhauser WD, Zheng Y, Fontenot JD, Koch NC, Polf JC, Schaffner B, Titt U, Zhang X, Zhu XR, Mohan R. Implementation of the Varian Eclipse System for Proton Therapy Treatment Planning. Med Phys 33:2284, 2006. e-Pub 2006.
- Titt U, Zheng Y, Zhu XR, Mohan R, Newhauser WD. Verification of a proton treatment-planning pencil-beam dose algorithm with Monte Carlo. Med Phys 33:2149, 2006. e-Pub 2006.
- Zhang L, Dong L, Ahamad A, Zhu XR, Garden AS, Ang KK, Mohan R. Deformable Image Registration for Cone-Beam CT (CBCT) Images for Implementation of Image-Guided Adaptive Radiotherapy. Int J Radiat Oncol Biol Phys 66(S1):S647-648, 2006. e-Pub 2006.
- Lu J, Zhu XR, Munro P, Jeung A, Mostafave H, Chi PCM, Balter P, Guerrero T, Mohan R, Pan T. Adaptive 4D Cone Beam CT. Int J Radiat Oncol Biol Phys 66(S1):S609, 2006. e-Pub 2006.
- Li H, Zhu XR, Zhang L Dong L, Ahamad L, Chao KSC, Morrison WH, Rosenthal DI, Schwartz DL, Garden AS. Assessment of Positioning Accuracy of Head and Neck Patients Receiving IMRT Using On-Board Imaging and Cone Beam CT. Int J Radiat Oncol Biol Phys 66(S1):S144-145, 2006. e-Pub 2006.
- Zhu XR, Mason B, Gao S, Zhang L, O'Danniel J, Wang H, Tung S, Wong P, Garden A, Ahamad A, Blanco A, Morrison W, Rosenthal D, Ang K, Dong L. Dosimetric impact of anatomic variations for head and neck cancer patients undergoing IMRT treatment analyzed by deformable imaging registration. Med Phys 32:2146, 2005. e-Pub 2005.
- Zhu XR, Kang Y, Gillin MT. Measurement of in-air output ratios for a linear accelerator with and without flattening filter. Med Phys 32:2059, 2005. e-Pub 2005.
- Zhang X, Dong L, Lee A, Cox J, Zhu XR, Wang X, Kang Y, Liu H, Mohan R. Impact of inter-fractional motion of the anatomy on prostate proton dose. Med Phys 32:2029-2030, 2005. e-Pub 2005.
- Zhang X, Dong, Zhu XR, Zein R, Lim J, Wang X, Lii M, Xu J, Kang Y, Gillin M, Mohan R. Software tools for transferring treatment plans between two commercial planning systems. Med. Phys 32:1969, 2005. e-Pub 2005.
- Tung S, Lii M, Lai P, Wong P, Mason B, Garden A, Chao K, Zhu XR. Clinical evaluation of direct machine parameter optimization algorithm for head and neck IMRT treatment. Med Phys 32:1971, 2005. e-Pub 2005.
- Stevens CW, Forster K, Zhu XR, Rice D, Munden R, Smythe R. Excellent local control and survival after extrapleural pnuemonectomy and IMRT for mesothelioma. Int J Radiat Oncol Biol Phys 63(S1):S103-104, 2005. e-Pub 2005.
- Wu TH, Zhu XR, Lai PA, Garden AS, Rosenthal DI, Morrison WH, Ahamad A, Schwartz D, Chiou JF, Huang KW, Yen CY, Chao KS. A planning technique for intensity modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys 63(S1):S530, 2005. e-Pub 2005.
- Tung S, Lii M, Zhu XR, Garden A. Comparison of IMRT prescription for head and neck cancers. Med Phys 31:1872, 2004. e-Pub 2004.
- Zhu XR, Zhang S, Lii M, Dong L, Kendall R, Forster R, Shiu A, Tung S, Gillin MT. Treatment planning quality and delivery efficiency for sMLC delivered IMRT treatments: Influence of the leaf width of MLC and the size of finite pencil beam. Med Phys 31:1721, 2004. e-Pub 2004.
- Zhu XR, Yoo S, Jursinic PA, Grimm DF, Lopez F, Rownd JJ, Gillin MT. Sensitometric characteristics of Kodak EDR film. Med Phys 30:1450, 2003. e-Pub 2003.
- Eastmo E Gillin MT, Zhu XR. Intensity modulated radiation therapy delivers out-of-Beam Total-body Doses that Are Significantly Higher than those Delivered with Three Dimensional Conformal Radiation Therapy. Int J Radiat Oncol Biol Phys 54:157, 2002. e-Pub 2002.
- Zhu XR, Schultz C, Jursinic PA, Gillin MT. IMRT treatment planning for static MLC delivery: Impact of number of gantry angles and levels of modulation on quality and efficiency of head and neck IMRT delivered per RTOG H-0022. Int J Radiat Oncol Biol Phys 54:320, 2002. e-Pub 2002.
- Jursinic PA, Zhu XR, Gillin MT. Implementation of Intensity Modulated Radiation Therapy, IMRT using solid filters (compensators) and static multileaf collimator. Supplement to Radiology, RSNA Scientific Program 2002 225:595, 2002. e-Pub 2002.
- Zhu XR, Jursinic PA, Grimm DF, Lopez F, Rownd JJ, Gillin MT. Directly deriving extrafocal radiation distribution for head-scatter factor calculations. Med Phys 29:1288, 2002. e-Pub 2002.
- Jursinic PA, Zhu XR, Gillin MT. A Comparison of Two Different Beam Modulation Approaches for Intensity Modulated Radiation Therapy, IMRT. Med Phys 29:1348, 2002. e-Pub 2002.
- Jursinic PA, Zhu XR, Nelms B. An implementation of solid filter (compensator)-based intensity modulated radiation therapy, IMRT, for clinical use. Med Phys 29:1266, 2002. e-Pub 2002.
- Willcut VM, Newman F, Zhu XR, Low DA, Percy J, Cain M, Markman J, Munger T, andNelms BE. Dosimetric verification of IMRT delivery: Varian, Siemens, and Elekta. Med Phys 29:1365, 2002. e-Pub 2002.
- Zhu XR, Jursinic PA, Grimm DF, Albano K, Lopez F, Rownd JJ, Gillin MT. Evaluation of Kodak EDR2 film for dose verifications of intensity modulated radiation therapy. Med Phys 28:1268, 2001. e-Pub 2001.
- Rownd JJ, Albano K, Gillin MT, Grimm DF, Jursinic PA, Lopez F, Zhu XR. Planning and Optimization of breast HDR Treatments. Med Phys 28:1297, 2001. e-Pub 2001.
- Jursinic PA, Zhu XR. Calculations of dose profiles under wedges using spatially dependent attenuation coefficients. Med Phys 28:1267, 2001. e-Pub 2001.
- Zhu XR, Jursinic PA, Albano K, Grimm DF, Lopez F, Rownd JJ, Gillin MT. Virtual and physical wedge factors: contributions of head and phantom scatters. Med Phys 28:1276, 2001. e-Pub 2001.
- Zhu XR, Gillin MT, Lopez F, Grimm, DF, Rownd JJ. Comparison of dosimetric properties of Siemens Virtual and physical wedges. World Congress on Medical Physics and Biomedical Engineering – Chicago 2000, 2000. e-Pub 2000.
- Miften MM, Zhu XR, Takahashi K, Lopez F, Gillin MT. Calculation of dose distributions with constraint checking for Siemens Virtual Wedge. World Congress on Medical Physics and Biomedical Engineering - Chicago2000, 2000. e-Pub 2000.
- Gillin MT, Zhu XR, Grimm D, Rownd J, Lopez F. Evaluation of Shielding and Function of a Dedicated HDR Room. Med Phys 26:1123, 1999. e-Pub 1999.
- Zhu XR, Gillin MT, Lopez F, Grimm D, Rownd J. Virtual Wedge Factors and Clinical Implementation of Siemens Virtual Wedge. Med Phys 26:1151, 1999. e-Pub 1999.
- Gillin MT, Zhu XR, Grimm D, Lopez F, Rownd J. Additioonal TBI Patient Dose from Neutrons Due to the Photon Beam Intercepting Steel as Opposed to Concrete. Med Phys 26:1150, 1999. e-Pub 1999.
- Zhu XR. Comparison of Two Types of Commercial Diode Detector For in-vivo Dosimetry of High Energy Photon Beams. Med Phys 25:A179, 1998. e-Pub 1998.
- Zhu XR, Shi J, Allen JJ. A Silicon Diode Detector for Dosimetry of Very-small Radiosurgery Cones. Med Phys 25:A165, 1998. e-Pub 1998.
- Zhu XR, Klein EE. Dose Distribution in Buildup Regions in High Energy Photon Beams. Med Phys 23:1113, 1996. e-Pub 1996.
- Low DA, Zhu XR, Harms WB, Klein EE, Purdy JA. Intensity Modulation Radiation Therapy with Fixed Portals Using Physical Modulators. Int J Radiat Oncol Biol Phys 36/1S:222, 1996. e-Pub 1996.
- Zhu XR, Klein EE, Low DA. Geometric and Dosimetric Analysis of Multileaf Collimation Conformity. Med Phys 23:1168, 1996. e-Pub 1996.
- Low DA, Zhu XR, Harms WB, Purdy JA. Beam-intensity Modulation Using Physical Filters. Med Phys 23:1101, 1996. e-Pub 1996.
- Low DA, Zhu XR, Harms WB, Klein EE, Purdy JA. Replacement of an Existing Clinical Compensating Filter System with CNC-milled Filters. Med Phys 23:1168-1169, 1996. e-Pub 1996.
- Zhu XR, Low DA, Purdy JA. Geometric Misalignment in Fixed-portal Intensity Modulation Radiation Therapy. Int J Radiat Oncol Biol Phys 36/1S:222, 1996. e-Pub 1996.
- Klein EE, Zhu XR, Low DA, Harms WB, Purdy JA. Clinical Implementation of Enhanced Dynamic Wedge. Int J Radiat Oncol Biol Phys 36/1S:394, 1996. e-Pub 1996.
- Morrison AE, Klein EE, J A Purdy JA, Graham MV, Zhu XR, Matthews JW, Low DA. Photon Dose Measurement and Calculations for Tumor within Lung: A Comparative 3D Study. Med Phys 22:976, 1995. e-Pub 1995.
- Low DA, Zhu XR, Harms WB, Purdy JA. Convolution Modification to a ratio-TAR Algorithm for 3D Photon Beam Treatment Planning: Kernel Measurement. Med Phys 21:912, 1994. e-Pub 1994.
- Zhu XR, Low DA, Harms WB Purdy JA. Convolution Modification to a ratio-TAR Algorithm for 3D Photon Beam Treatment Planning: Algorithm and Implementation. Med Phys 21:878, 1994. e-Pub 1994.
Book Chapters
- Zhu XR, Frank SJ, Palmer M. Technological Advancements in Proton Therapy. In: Proton Therapy. Elsevier, 2020.
- Zhu XR, Poenisch F, Sahoo N, and Gillin MT. Clinical Commissioning of Pencil Beam Scanning for Intensity-modulated Proton Therapy. In: Proton Therapy. Elsevier, 2020.
- Guatam A, Wu R, Zhu XR, and Poenisch F. Immobilization and Simulation. In: Proton Therapy. Elsevier, 2020.
- Gillin MT, Hojo Y, Sahoo N, Zhu XR. Intensity-Modulated Proton Therapy Patient Treatments. In: Proton Therapy. Elsevier, 2020.
- Sahoo N, Sawakuchi GO, Gillin MT, Zhu XR. Radiation Dosimetry of Proton Beams. In: Particle Radiotherapy - Emerging Technology for Treatment of Cancer. Springer, 77-94, 2016.
- Zhu XR, Poenisch F, Li H, Zhang X, Sahoo N, and Gillin MT. Field Shaping: Scanning Beam. In: Principles and Practices of Proton Beam Therapy. Medical Physics Publishing, 209-228, 2015.
- Mohan R, Zhu XR, and Paganetti H. Dose Calculation for proton beam therapy: Semi-empirical analytical methods. In: Principles and Practices of Proton Beam Therapy. Medical Physics Publishing, 595-622, 2015.
- Li H, Giebeler A, Dong L, Zhang X, Poenisch F, Sahoo N, Gillin MT, Zhu XR. Treatment planning for passive scatterng proton therapy. In: Principles and Practices of Proton Beam Therapy. Medical Physics Publishing, 647-665, 2015.
- Sahoo N, Gautam AS, Poenisch F, Zhu XR, Li H, Zhang X, Wu R, Beddar S, and Gillin MT. In vivo Dosimetry for proton therapy. In: Principles and Practices of Proton Beam Therapy, 795-817, 2015.
- Gillin MT, Zhu XR, and Sahoo N. Considerations for an Effective Quality Assurance Program for Proton Therapy. In: Ion Beam Therapy Fundamentals, Technology, Clinical Applications. Springer, 471-485, 2012.
- Dong L, Cheung J, Zhu XR. Image-guided Proton and Carbon Ion Therapy. In: Proton and Carbon Ion Therapy. CRC Press;, 127-150, 2012.
Books (edited and written)
- Frank SJ, Zhu XR. Proton Therapy - Indications, Techniques, and Outcomes. Elsevier, 2020.
Patient Reviews
CV information above last modified March 31, 2026