Xi Chen, Ph.D.
Department of Experimental Therapeutics, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Member, James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Member, James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2009 | National University of Singapore, Singapore, SG, Stem Cells, Ph.D |
| 2003 | Dalian University of Technology, Dalian, CN, Bioengineering, BS |
Postgraduate Training
| 2012-2015 | Postdoctoral Fellowship, Weill Cornell Medical College, New York, New York |
| 2009-2012 | Postdoctoral Fellowship, Harvard School of Public Health and Harvard Medical School, Boston, Massachusetts |
Experience & Service
Academic Appointments
Associate Professor, Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, 2021 - 2024
Cullen Duncan McAshan Endowed Chair in Cancer Research, Baylor College of Medicine, Houston, TX, 2021 - 2024
Assistant Professor, CPRIT Scholar in Cancer Research, Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, 2015 - 2021
Postdoctoral Associate, Weill Cornell Medical College, New York, NY, 2012 - 2015
Leukemia and Lymphoma Society Fellow in the laboratory of Dr. Laurie Glimcher, Harvard School of Public Health and Harvard Medical School, Boston, MA, 2009 - 2012
Institutional Committee Activities
Member, Baylor College of Medicine Dan L. Duncan Comprehensive Cancer Center Grants Review Committee, 2022 - 2024
Mentor, Career Development Forum, San Antonio Breast Cancer Symposium, 2022 - 2022
Member, MCB Retreat Planning Committee. Baylor College of Medicine, 2022 - 2024
Chair, MCB DeBakey Space Planning Committee, Baylor College of Medicine, 2021 - 2021
Member, CPSB Graduate Program Admission, Baylor College of Medicine, 2020 - 2024
Ambassador, Inclusion and Equity Ambassador, Baylor College of Medicine, 2020 - 2024
Member, MCB Faculty Search Committee, Baylor College of Medicine, 2019 - 2024
Member, MCB Wednesday Seminar Series Committee, Baylor College of Medicine, 2019 - 2024
Member, Cancer and Cell Biology Graduate Program Admission, 2019 - 2024
Member, Standing Examination Committee of the Graduate Program, Baylor College of Medicine, 2018 - 2024
Judge, MCB Graduate Student Symposium, Baylor College of Medicine, 2015 - 2018
Member, MCB Graduate Student Program Admission, Baylor College of Medicine, 2015 - 2018
Honors & Awards
| 2021 | Cullen Duncan McAshan Endowed Chair in Cancer Research, Baylor College of Medicine |
| 2019 | American Cancer Society Research Scholar, American Cancer Society |
| 2019 | DOD Peer Reviewed Cancer Research Program Impact Award, Department of Defense |
| 2018 | NIH Merit Award for ESI, National Insitute of Health |
| 2016 | Susan G. Komen Career Catalyst Award, Susan G. Komen Breast Cancer Foundation |
| 2015 | CPRIT Scholar in Cancer Research, Cancer Prevention and Research Institute of Texas |
| 2015 | Breast Cancer SPORE Career Development Award, National Cancer Institute |
| 2009 | Leukemia & Lymphoma Society Career Development Fellow Award, Leukemia & Lymphoma Society |
| 2009 | The Cancer Research Institute fellowship, Cancer Research Institute |
| 2009 | The Human Frontier Science Program Fellowship, International Human Frontier Science Program Organization |
| 2008 | Best Graduate Researcher Award, National University of Singapore |
| 2008 | Top Graduate Researcher Award, National University of Singapore |
| 2007 | Singapore Millennium Foundation Scholarship, SMF Foundation |
| 2004 | National University of Singapore Research Scholarship, National University of Singapore |
| 2004 | President Graduate Fellowship, National University of Singapore |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Maneix L, Iakova P, Lee CG, Moree SE, Lu X, Datar GK, Hill CT, Spooner E, King JCK, Sykes DB, Saez B, Di Stefano B, Chen X, Krause DS, Sahin E, Tsai FTF, Goodell MA, Berk BC, Scadden DT, Catic A. Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing. Nat Cell Biol 26(4):593-603, 2024. e-Pub 2024. PMID: 38553595.
- Liu, Y, Zhao, S, Chen, Y, Ma, W, Lu, S, He, L, Chen, J, Chen, X, Zhang, X, Shi, Y, Jiang, X, Zhao, K. Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition. Cellular Oncology 46(6):1791-1806, 2023. e-Pub 2023. PMID: 37646965.
- Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, Han D, Malmberg E, Chan DW, Wang X, Savage SR, Mao S, Yu J, Peng F, Yan L, Meng H, Maneix L, Han Y, Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X. Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors. Science 381(6662):eabn4180, 2023. e-Pub 2023. PMID: 37676964.
- Zheng C, Wei Y, Zhang Q, Sun M, Wang Y, Hou J, Zhang P, Lv X, Su D, Jiang Y, Gumin J, Sahni N, Hu B, Wang W, Chen X, McGrail DJ, Zhang C, Huang S, Xu H, Chen J, Lang FF, Hu J, Chen Y. Multiomics analyses reveal DARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. Sci Adv 9(31):eadf3984, 2023. e-Pub 2023. PMID: 37540752.
- Zheng C, Wei Y, Zhang P, Xu L, Zhang Z, Lin K, Hou J, Lv X, Ding Y, Chiu Y, Jain A, Islam N, Malovannaya A, Wu Y, Ding F, Xu H, Sun M, Chen X, Chen Y. CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer. J Clin Invest 133(5), 2023. e-Pub 2023. PMID: 36856111.
- Zhang W, Xu Z, Hao X, He T, Li J, Shen Y, Liu K, Gao Y, Liu J, Edwards DG, Muscarella AM, Wu L, Yu L, Xu L, Chen X, Wu YH, Bado IL, Ding Y, Aguirre S, Wang H, Gugala Z, Satcher RL, Wong STC, Zhang XH. Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells. Cancer Discov 13(2):474-495, 2023. e-Pub 2023. PMID: 36287038.
- Liu, Y, Lu, S, Sun, Y, Wang, F, Yu, S, Chen, X, Wu, L, Yang, H, Shi, Y, Zhao, K. Deciphering the role of QPCTL in glioma progression and cancer immunotherapy. Frontiers in immunology 14, 2023. e-Pub 2023. PMID: 37063864.
- Lin M, Ku AT, Dong J, Yue F, Jiang W, Ibrahim AA, Peng F, Creighton CJ, Nagi C, Gutierrez C, Rosen JM, Zhang XH, Hilsenbeck SG, Chen X, Du YN, Huang S, Shi A, Fan Z, Li Y. STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential. Oncogene 41(48):5214-5222, 2022. e-Pub 2022. PMID: 36261627.
- Ghosh S, Raundhal M, Myers SA, Carr SA, Chen X, Petsko GA, Glimcher LH. Identification of RIOK2 as a master regulator of human blood cell development. Nat Immunol 23(1):109-121, 2022. e-Pub 2022. PMID: 34937919.
- Sun M, Wang Y, Zheng C, Wei Y, Hou J, Zhang P, He W, Lv X, Ding Y, Liang H, Hon CC, Chen X, Xu H, Chen Y. Systematic functional interrogation of human pseudogenes using CRISPRi. Genome Biol 22(1):240, 2021. e-Pub 2021. PMID: 34425866.
- Liu X, Yu J, Xu L, Umphred-Wilson K, Peng F, Ding Y, Barton BM, Lv X, Zhao MY, Sun S, Hong Y, Qi L, Adoro S, Chen X. Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection. Elife 10, 2021. e-Pub 2021. PMID: 34240701.
- Shao R, Zhang Z, Xu Z, Ouyang H, Wang L, Ouyang H, Greenblatt M, Chen X, Zou W. H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Res 9(1):30, 2021. e-Pub 2021. PMID: 34099628.
- Xu J, Shi J, Cui X, Cui Y, Li JJ, Goel A, Chen X, Issa JP, Su J, Li W. Cellular Heterogeneity-Adjusted cLonal Methylation (CHALM) improves prediction of gene expression. Nat Commun 12(1):400, 2021. e-Pub 2021. PMID: 33452255.
- Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat Cell Biol 22(10):1162-1169, 2020. e-Pub 2020. PMID: 32958856.
- Lv X, Dobrolecki LE, Ding Y, Rosen JM, Lewis MT, Chen X. Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer. J Vis Exp(159), 2020. e-Pub 2020. PMID: 32478757.
- Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Kim J, Ma L, Li W, Rosen JM. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res 48(5):2621-2642, 2020. e-Pub 2020. PMID: 31863590.
- Zheng ZY, Anurag M, Lei JT, Cao J, Singh P, Peng J, Kennedy H, Nguyen NC, Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. Cancer Cell 37(3):387-402.e7, 2020. e-Pub 2020. PMID: 32142667.
- Pan Y, Ballance H, Meng H, Gonzalez N, Kim SM, Abdurehman L, York B, Chen X, Schnytzer Y, Levy O, Dacso CC, McClung CA, O'Malley BW, Liu S, Zhu B. 12-h clock regulation of genetic information flow by XBP1s. PLoS Biol 18(1):e3000580, 2020. e-Pub 2020. PMID: 31935211.
- Ruan H, Xiang Y, Ko J, Li S, Jing Y, Zhu X, Ye Y, Zhang Z, Mills T, Feng J, Liu CJ, Jing J, Cao J, Zhou B, Wang L, Zhou Y, Lin C, Guo AY, Chen X, Diao L, Li W, Chen Z, He X, Mills GB, Blackburn MR, Han L. Comprehensive characterization of circular RNAs in ~?1000 human cancer cell lines. Genome Med 11(1):55, 2019. e-Pub 2019. PMID: 31446897.
- Yuan B, Liu J, Cao J, Yu Y, Zhang H, Wang F, Zhu Y, Xiao M, Liu S, Ye Y, Ma L, Xu D, Xu N, Li Y, Zhao B, Xu P, Jin J, Xu J, Chen X, Shen L, Lin X, Feng XH. PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity. EMBO J 38(14):e99945, 2019. e-Pub 2019. PMID: 31304624.
- Dong H, Adams NM, Xu Y, Cao J, Allan DSJ, Carlyle JR, Chen X, Sun JC, Glimcher LH. The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. Nat Immunol 20(7):865-878, 2019. e-Pub 2019. PMID: 31086333.
- Jiang X, Zhang C, Chen J, Choi S, Zhou Y, Zhao M, Song X, Chen X, Maletic-Savatic M, Palzkill T, Moore D, Wang MC, Wang J. Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution. Antioxid Redox Signal 30(16):1900-1910, 2019. e-Pub 2019. PMID: 30358421.
- Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q. Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells. Nat Cell Biol 21(3):328-337, 2019. e-Pub 2019. PMID: 30778220.
- Lu Y, Cao J, Napoli M, Xia Z, Zhao N, Creighton CJ, Li W, Chen X, Flores ER, McManus MT, Rosen JM. miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution. Stem Cells 36(12):1875-1889, 2018. e-Pub 2018. PMID: 30267595.
- Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes 67(12):2541-2553, 2018. e-Pub 2018. PMID: 30002134.
- Lei JT, Shao J, Zhang J, Iglesia M, Chan DW, Cao J, Anurag M, Singh P, He X, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, Ramalho S, Peres RMR, Punturi N, Schmidt C, Bartram A, Jou E, Devarakonda V, Holloway KR, Lai WV, Hampton O, Rogers A, Tobias E, Parikh PA, Davies SR, Li S, Ma CX, Suman VJ, Hunt KK, Watson MA, Hoadley KA, Thompson EA, Chen X, Kavuri SM, Creighton CJ, Maher CA, Perou CM, Haricharan S, Ellis MJ. Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer. Cell Rep 24(6):1434-1444.e7, 2018. e-Pub 2018. PMID: 30089255.
- Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128(4):1283-1299, 2018. e-Pub 2018. PMID: 29480818.
- Cao J, Yu Y, Zhang Z, Chen X, Hu Z, Tong Q, Chang J, Feng XH, Lin X. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Diabetes 67(1):46-57, 2018. e-Pub 2018. PMID: 28851713.
- Zhang P, He D, Xu Y, Hou J, Pan BF, Wang Y, Liu T, Davis CM, Ehli EA, Tan L, Zhou F, Hu J, Yu Y, Chen X, Nguyen TM, Rosen JM, Hawke DH, Ji Z, Chen Y. Genome-wide identification and differential analysis of translational initiation. Nat Commun 8(1):1749, 2017. e-Pub 2017. PMID: 29170441.
- Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG, Liu XS, Zhang Q. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J 34(23):2953-70, 2015. e-Pub 2015. PMID: 26492917.
- Chen K, Chen Z, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y, Xia Z, Chen X, Shi X, Wang Q, Li W. Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes. Nat Genet 47(10):1149-57, 2015. e-Pub 2015. PMID: 26301496.
- Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LH. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nat Commun 6:7562, 2015. e-Pub 2015. PMID: 26108174.
- Fang F, Xu Y, Chew KK, Chen X, Ng HH, Matsudaira P. Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure. Stem Cells 32(7):1805-16, 2014. e-Pub 2014. PMID: 24648406.
- Dave B, Granados-Principal S, Zhu R, Benz S, Rabizadeh S, Soon-Shiong P, Yu KD, Shao Z, Li X, Gilcrease M, Lai Z, Chen Y, Huang TH, Shen H, Liu X, Ferrari M, Zhan M, Wong ST, Kumaraswami M, Mittal V, Chen X, Gross SS, Chang JC. Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling. Proc Natl Acad Sci U S A 111(24):8838-43, 2014. e-Pub 2014. PMID: 24876273.
- Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 508(7494):103-107, 2014. e-Pub 2014. PMID: 24670641.
- Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, Chen X, Liu XS, Brown M, Lim B, Weinberg RA. Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 24(3):347-64, 2013. e-Pub 2013. PMID: 24029232.
- Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol 12(1):96-104, 2011. e-Pub 2011. PMID: 21151104.
- Zou W, Chen X, Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones D. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol 13(1):59-65, 2011. e-Pub 2011. PMID: 21170031.
- Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11(5):411-8, 2010. e-Pub 2010. PMID: 20351694.
- Bourque G, Leong B, Vega VB, Chen X, Lee YL, Srinivasan KG, Chew JL, Ruan Y, Wei CL, Ng HH, Liu ET. Evolution of the mammalian transcription factor binding repertoire via transposable elements. Genome Res 18(11):1752-62, 2008. e-Pub 2008. PMID: 18682548.
- Chen X, Fang F, Liou YC, Ng HH. Zfp143 regulates Nanog through modulation of Oct4 binding. Stem Cells 26(11):2759-67, 2008. e-Pub 2008. PMID: 18687992.
- Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133(6):1106-17, 2008. e-Pub 2008. PMID: 18555785.
- Loh YH, Zhang W, Chen X, George J, Ng HH. Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev 21(20):2545-57, 2007. e-Pub 2007. PMID: 17938240.
- Lim LS, Loh YH, Zhang W, Li Y, Chen X, Wang Y, Bakre M, Ng HH, Stanton LW. Zic3 is required for maintenance of pluripotency in embryonic stem cells. Mol Biol Cell 18(4):1348-58, 2007. e-Pub 2007. PMID: 17267691.
- Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem 281(34):24090-4, 2006. e-Pub 2006. PMID: 16840789.
- Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38(4):431-40, 2006. e-Pub 2006. PMID: 16518401.
- Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, Ng HH. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25(14):6031-46, 2005. e-Pub 2005. PMID: 15988017.
Other Articles
- Xu, L, Liu, Y, Chen, X, Zhong, H, Wang, Y Ferroptosis in life. Biomedicine and Pharmacotherapy 159, 2023. PMID: 36634587.
- Liu, Y, Sun, Y, Guo, Y, Shi, X, Chen, X, Feng, W, Wu, L, Zhang, J, Yu, S, Wang, Y, Shi, Y An Overview. International journal of biological sciences 19(3):897-915, 2023. PMID: 36778129.
- Shao, R, Zhang, Z, Xu, Z, Ouyang, H, Wang, L, Ouyang, H, Greenblatt, MB, Chen, X, Zou, WG Correction. Bone Research 9(1), 2021. PMID: 34312364.
- Chen X, Cubillos-Ruiz JR Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer 21(2):71-88, 2021. PMID: 33214692.
- Xu L, Zhang W, Zhang XH, Chen X Endoplasmic Reticulum Stress in Bone Metastases. Front Oncol 10:1100, 2020. PMID: 32850317.
- Ma H, Ow JR, Chen X, Wu Q With or Without them: Essential Roles of Cofactors in ES Cells. J Stem Cell Res Ther(S10:006), 2012.
- Chen X, Vega VB, Ng HH Transcriptional regulatory networks in embryonic stem cells. Cold Spring Harb Symp Quant Biol 73:203-9, 2008. PMID: 19022762.
Book Chapters
- Zhao N, Peng F, Chen X. The Unfolded Protein Response in Triple-Negative Breast Cancer. In: Cancer Drug Discovery and Development. Humana Press, 133-161, 2019.
Selected Presentations & Talks
Local Presentations
- 2024. Stress management in therapy resistant cancers. Conference. Stress management in therapy resistant cancers. Houston, TX, US.
- 2024. Stressing out therapy resistant cancers. Conference. Stressing out therapy resistant cancers. Houston, TX, US.
- 2024. Stressing out therapy resistant cancers. Conference. Stressing out therapy resistant cancers. Houston, TX, US.
- 2022. Targeting the unfolded protein response to reverse therapy resistance. Conference. Targeting the unfolded protein response to reverse therapy resistance. Houston, TX, US.
- 2020. Targeting the unfolded protein response in breast cancer. Conference. Targeting the unfolded protein response in breast cancer. Houston, TX, US.
- 2020. Targeting the unfolded protein response in breast cancer. Conference. Targeting the unfolded protein response in breast cancer. Houston, TX, US.
- 2019. Targeting the endoplasmic reticulum stress response to reverse therapy resistance. Conference. Targeting the endoplasmic reticulum stress response to reverse therapy resistance. Houston, TX, US.
- 2018. University of Texas MD Anderson Cancer Center. Conference. University of Texas MD Anderson Cancer Center. Houston, TX, US.
- 2018. Targeting the unfolded protein response to overcome therapy resistance in breast cancer. Conference. Targeting the unfolded protein response to overcome therapy resistance in breast cancer. Houston, TX, US.
- 2018. Unfolding the unfolded protein response in breast cancer. Conference. Unfolding the unfolded protein response in breast cancer. Houston, TX, US.
- 2017. Stressing out MYC-driven triple-negative breast cancer. Conference. Stressing out MYC-driven triple-negative breast cancer. Houston, TX, US.
- 2017. Stressing out triple-negative breast cancer. Conference. Stressing out triple-negative breast cancer. Houston, TX, US.
Regional Presentations
- 2022. Unfolding the unfolded protein response in breast cancer therapy resistance. Conference. Unfolding the unfolded protein response in breast cancer therapy resistance. Dallas, TX, US.
- 2017. Stressing out triple-negative breast cancer. Conference. Stressing out triple-negative breast cancer. Dallas, TX, US.
- 2016. Unfolding the unfolded protein response in breast cancer. Conference. Unfolding the unfolded protein response in breast cancer. San Antonio, TX, US.
National Presentations
- 2022. ERADicating abnormal stem cells from the niche. Conference. ERADicating abnormal stem cells from the niche. Ann Arbor, MI, US.
- 2021. Targeting the Unfolded Protein Response to reverse therapy resistance. Conference. Targeting the Unfolded Protein Response to reverse therapy resistance.
- 2019. Targeting the unfolded protein response to reverse cancer therapy resistance. Conference. Targeting the unfolded protein response to reverse cancer therapy resistance. Scottsdale, AZ, US.
- 2017. Stressing out MYC-driven triple-negative breast cancer. Conference. Stressing out MYC-driven triple-negative breast cancer. Houston, TX, US.
International Presentations
- 2024. Targeting stress responses in therapy-resistant cancers. Conference. Targeting stress responses in therapy-resistant cancers. Singapore, SG.
- 2024. Stress management in therapy-resistant cancers. Conference. Stress management in therapy-resistant cancers. Cyprus, GR.
- 2024. Targeting ER stress Response to Reprogram Tumor microenvironment and Reverse Resistance to Immunotherapy. Conference. Targeting ER stress Response to Reprogram Tumor microenvironment and Reverse Resistance to Immunotherapy. Loutraki, GR.
- 2023. Stressing out therapy-resistant cancers. Conference. Stressing out therapy-resistant cancers. Boston, US.
- 2023. Stressing out therapy-resistant cancers. Conference. Stressing out therapy-resistant cancers. Kalamata, GR.
- 2021. ERADicating Stem Cells in the Microenvironment. Conference. ERADicating Stem Cells in the Microenvironment.
- 2021. Crosstalk between Oncogenic Stress and ER stress in Cancer. Conference. Crosstalk between Oncogenic Stress and ER stress in Cancer. Kos, GR.
- 2019. Protein quality control through endoplasmic reticulum-associated degradation is essential to maintain hematopoietic stem cells. Conference. Protein quality control through endoplasmic reticulum-associated degradation is essential to maintain hematopoietic stem cells. Suzhou, CN.
- 2019. Regulation of hematopoietic stem cell identity by ER associated degradation. Conference. Regulation of hematopoietic stem cell identity by ER associated degradation. Toronto, CA.
- 2017. Crosstalk between ER stress and oncogenic stress in breast cancer. Conference. Crosstalk between ER stress and oncogenic stress in breast cancer. Ericeira, PT.
- 2017. Therapeutic exploitation of the unfolded protein response in breast cancer. Conference. Therapeutic exploitation of the unfolded protein response in breast cancer. Rome, IT.
Formal Peers
- 2023. Targeting Stress Responses to Reverse Therapy Resistance. Invited. Targeting Stress Responses to Reverse Therapy Resistance. Philadelphia, PA, US.
- 2022. Unfolding the unfolded protein response in breast cancer therapy resistance. Invited. Unfolding the unfolded protein response in breast cancer therapy resistance, US.
- 2018. The role of ER protein quality control machinery in the maintenance of hematopoietic stem cells. Invited. The role of ER protein quality control machinery in the maintenance of hematopoietic stem cells. Houston, TX, US.
- 2018. Regulation of hematopoietic stem cell by ER associated degradation. Invited. Regulation of hematopoietic stem cell by ER associated degradation. Ann Arbor, MI, US.
Grant & Contract Support
| Date: | 2023 - 2027 |
| Title: | Harnessing Endoplasmic Reticulum Stress to Overcome Resistance to Immunotherapy in Immune-Cold Breast Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP230285 |
| Date: | 2022 - 2027 |
| Title: | Proteostasis reprogramming in mutant KRAS-driven cancers |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01CA270240 |
| Date: | 2022 - 2024 |
| Title: | AACR-AstraZeneca Breast Cancer Research Fellowship |
| Funding Source: | American Association for Cancer Research (AACR) |
| Role: | Mentor |
| Date: | 2021 - 2024 |
| Title: | Lysosomal NADPH Metabolism Regulates Proteostasis, Aging and Tauopathy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | RF1AG074540 |
| Date: | 2020 - 2025 |
| Title: | Targeting Endoplasmic Reticulum Stress Sensor IRE1 to Enhance Chemotherapy Sensitivity in MYC-driven Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | P50CA186784 |
| Date: | 2019 - 2023 |
| Title: | Non-canonical Function and Regulation of the Unfolded Protein Response in Mutant KRAS-driven Pancreatic Ductal Adenocarcinoma |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | PI |
| ID: | W81XWH-19-1-0524 |
| Date: | 2019 - 2025 |
| Title: | Mechanism and Function of Endoplasmic Reticulum Protein Quality Control Machinery in the Maintenance of Hematopoietic Stem Cells |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01HL146642 |
| Date: | 2019 - 2024 |
| Title: | DNA Methylation Canyons in Human Cancers: Methods, Target Genes and Functional Consequences |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA228140 |
| Date: | 2019 - 2023 |
| Title: | Breast Cancer Breakthrough Fellowship Award |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Mentor |
| ID: | W81XWH-19-1-0035 |
| Date: | 2019 - 2023 |
| Title: | Integration of the Oncogenic Stress with ER Stress in Breast Cancer |
| Funding Source: | American Cancer Society (ACS) |
| Role: | PI |
| ID: | RSG-18-181-01-TBE |
| Date: | 2018 - 2025 |
| Title: | Crosstalk between the ER Stress Response and Mitochondrial Fatty Acid Oxidation in MYC-driven Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R37CA228304 |
| Date: | 2018 - 2021 |
| Title: | Therapeutic Efficacy of IRE1 Inhibitor in MC1 PDX Tumors |
| Funding Source: | Orinove Inc |
| Role: | PI |
| Date: | 2017 - 2019 |
| Title: | Broad Shortening of 3’UTRS in Human Cancers |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | CPRIT-IIRA |
| Date: | 2016 - 2019 |
| Title: | Therapeutic Exploration of IRE1/XBP1 axis of Unfolded Protein Response in TNBC |
| Funding Source: | Susan G. Komen Breast Cancer Foundation |
| Role: | PI |
| ID: | CCR16380871 |
| Date: | 2015 - 2017 |
| Title: | Translational Research In Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Career Development Project Leader |
| ID: | P50CA186784 |
| Date: | 2015 - 2020 |
| Title: | Recruitment of First-Time, Tenure-Track Faculty Members |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RR150009 |
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CV information above last modified March 27, 2025