Xiangsheng Zuo, M.D., Ph.D.
Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine
About Dr. Zuo
I am a senior cancer research scientist with an extensive laboratory, preclinical, and clinical research experience. My research has been utilizing patient tissue samples, and multiple transgenic mouse models of gastric, colorectal, and pancreatic cancers to understand the role and underlying molecular mechanisms of the determining factors (i.e., PPAR-δ and 15-LOX-1 signaling) in the initiation and progression of those gastrointestinal cancers. The new molecular understanding might lead to the development of preventive and therapeutic interventions to reduce the enormous health burden of these cancers.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Gastrointestinal (GI) Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Transgenic mouse modeling; Gastrointestinal cancer pathogenesis; Stem/progenitor cell transformation; Host and environment interaction; Remodeling of tumor immune microenvironment; and Chemoprevention
Education & Training
Degree-Granting Education
| 2001 | Shanghai Jiao-Tong University Medical School, Shanghai, CHN, PHD, Internal Medicine (specialized in Endocrinology) |
| 1990 | Anhui Medical University, Anhui, CHN, MS, Pathophysiology |
| 1987 | Bengbu Medical College, Anhui, CHN, MD, Medicine |
Postgraduate Training
| 2002-2006 | Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX |
Experience & Service
Academic Appointments
Assistant Professor, Department of Clinical Cancer Prevention, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2011
Instructor, Department of Clinical Cancer Prevention, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2010
Selected Publications
Peer-Reviewed Articles
- Liu Y, Deguchi Y, Wei D, Liu F, Moussalli MJ, Deguchi E, Li D, Wang H, Valentin LA, Colby JK, Wang J, Zheng X, Ying H, Gagea M, Ji B, Shi J, Yao JC, Zuo X, Shureiqi I. Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. Nat Commun 13(1):2665, 2022. PMID: 35562376.
- Yang P, Zuo X, Advani S, Wei B, Malek J, Day RS, Shureiqi I. Celecoxib Colorectal Bioavailability and Chemopreventive Response in Familial Adenomatous Polyposis Patients. Cancer Prev Res (Phila) 15(4):217-223, 2022. e-Pub 2021. PMID: 34610992.
- Kapalczynska M, Lin M, Maertzdorf J, Heuberger J, Muellerke S, Zuo X, Vidal R, Shureiqi I, Fischer AS, Sauer S, Berger H, Kidess E, Mollenkopf H, Tacke F, Meyer TF, Sigal M.. BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation. Nature Communications 13(1):1577, 2022. PMID: 35332152.
- Pudakalakatti S, Titus M, Enriquez JS, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci 23(3):1645, 2022. e-Pub 2022. PMID: 35163565.
- Wei D, Wang L, Zuo X, Bresalier RS. Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer. Cancers (Basel) 13(11), 2021. e-Pub 2021. PMID: 34072725.
- Liu F, Zuo X, Liu Y, Deguchi Y, Moussalli MJ, Chen W, Yang P, Wei B, Tan L, Lorenzi PL, Gao S, Jaoude JC, Mehdizadeh A, Valentin LA, Wei D, Shureiqi I. Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P. Cell Rep 32(7):108049, 2020. PMID: 32814052.
- Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and interferon gamma promote transformation of gastric progenitor cells and tumorigenesis in mice. Gastroenterology 157(1):163-178, 2019. e-Pub 2019. PMID: 30885780.
- Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris JS, Broaddus R, Zuo X, Shureiqi I. Pleotropic effects of PPARD accelerate colorectal tumorigenesis, progression, and invasion. Cancer Res 79(5):954-969, 2019. e-Pub 2019. PMID: 30679176.
- Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I. The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. Int J Mol Sci 19(11), 2018. e-Pub 2018. PMID: 30373124.
- Wang L, Zuo X, Xie K, Wei D.. The Role of CD44 and Cancer Stem Cells. Methods Mol Biol 1692:31-42, 2018. PMID: 28986884.
- Tian R, Zuo X, Jaoude J, Mao F, Colby J, Shureiqi I. ALOX15 as a suppressor of inflammation and cancer: Lost in the link. Prostaglandins Other Lipid Mediat 132:132:77-83, 2017. e-Pub 2017. PMID: 28089732.
- Xie VK, Li Z, Yan Y, Jia Z, Zuo X, Ju Z, Wang J, Du J, Xie D, Xie K, Wei D. DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression. Clin Cancer Res 23(18):5585-5597, 2017. e-Pub 2017. PMID: 28659310.
- Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I. Metastasis regulation by PPARD expression in cancer cells. JCI Insight 12(1):e91419. doi: 10.1172/jci.insight.91419, 2017. e-Pub 2017. PMID: 28097239.
- Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res 76(8):2419-31, 2016. e-Pub 2016. PMID: 26880805.
- Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell 29(3):324-38, 2016. PMID: 26977883.
- Yan Y, Zuo X, Wei D. Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target. Stem Cells Transl Med 4(9):1033-43, 2015. e-Pub 2015. PMID: 26136504.
- Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli MJ, Elias E, Li HS, Watowich SS, Shureiqi I. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J 29(6):2359-70, 2015. e-Pub 2015. PMID: 25713055.
- Wu Y, Mao F, Zuo X, Moussalli MJ, Elias E, Xu W, Shureiqi I. 15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1α expression in human colon cancer cells. Cancer Med 3(3):472-84, 2014. e-Pub 2014. PMID: 24634093.
- Zuo X, Xu M, Yu J, Wu Y, Moussalli MJ, Manyam GC, Lee SI, Liang S, Gagea M, Morris JS, Broaddus RR, Shureiqi I. Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression. J Natl Cancer Inst 106(4):dju052, 2014. e-Pub 2014. PMID: 24681603.
- Zuo X, Shureiqi I. Eicosanoid profiling in colon cancer: Emergence of a pattern. Prostaglandins Other Lipid Mediat 104-105:139-43, 2013. e-Pub 2012. PMID: 22960430.
- Xu M, Zuo X, Shureiqi I. Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: How to aim?. Biochem Pharmacol 85(5):607-11, 2013. e-Pub 2012. PMID: 23041232.
- Zuo X, Peng Z, Wu Y, Moussalli MJ, Yang XL, Wang Y, Parker-Thornburg J, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice. J Natl Cancer Inst 104(9):709-16, 2012. e-Pub 2012. PMID: 22472308.
- Moussalli MJ, Wu Y, Zuo X, Yang XL, Wistuba II, Raso MG, Morris JS, Bowser JL, Minna JD, Lotan R, Shureiqi I. Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion. Cancer Prev Res (Phila) 4(12):1961-72, 2011. e-Pub 2011. PMID: 21881028.
- Il Lee S, Zuo X, Shureiqi I. 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?. Cancer Metastasis Rev 30(3-4):481-91, 2011. PMID: 22037943.
- Shureiqi I, Chen D, Day RS, Zuo X, Hochman FL, Ross WA, Cole RA, Moy O, Morris JS, Xiao L, Newman RA, Yang P, Lippman SM. Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis. Cancer Prev Res (Phila) 3(7):829-38, 2010. e-Pub 2010. PMID: 20570882.
- Zuo X, Peng Z, Moussalli MJ, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. J Natl Cancer Inst 101(10):762-7, 2009. e-Pub 2009. PMID: 19436036.
- Zuo X, Morris JS, Broaddus R, Shureiqi I. 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells. Oncogene 28(12):1496-505, 2009. e-Pub 2009. PMID: 19198625.
- Zuo X, Morris JS, Shureiqi I. Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells. J Biol Chem 283(46):31341-7, 2008. e-Pub 2008. PMID: 18799463.
- Zuo X, Shen L, Issa JP, Moy O, Morris JS, Lippman SM, Shureiqi I. 15-Lipoxygenase-1 transcriptional silencing by the DNA methyltransferase-1 independently of DNA methylation. FASEB J 22(6):1981-92, 2008. e-Pub 2008. PMID: 18198215.
- Shureiqi I, Zuo X, Broaddus R, Wu Y, Guan B, Morris JS, Lippman SM. The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer. FASEB J 21(3):743-53, 2007. e-Pub 2006. PMID: 17167069.
- Zuo X, Wu Y, Morris JS, Stimmel JB, Leesnitzer LM, Fischer SM, Lippman SM, Shureiqi I. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. Oncogene 25(8):1225-1241, 2006. PMID: 16288226.
- Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci U S A 100(17):9968-9973, 2003. e-Pub 2003. PMID: 12909723.
- Zuo X, Li G, Luo T, Li J, Liu Y, Luo M. Differentiation of NIH3T3 fibroblasts into adipocytes induced by peroxisome proliferator activated receptor gamma 2 expression. Chin Med J (Engl) 114(9):916-20, 2001. PMID: 11780381.
- Zuo X, Li G, Luo T, Li J, Liu Y, Sun W, Luo M. [Adipocytes differentiation of NIH3T3 cells induced by peroxisome proliferator activation receptor gamma 2 expression]. Zhonghua Nei Ke Za Zhi 40(4):247-50, 2001. PMID: 11798586.
- Zuo X, Su B, Wei D. Isolation and characterization of early pregnancy factor. Chin Med Sci J 9(1):34-7, 1994. PMID: 8086632.
Book Chapters
- Wang L, Zuo X, Xie K, Wei D. The Role of CD44 and Cancer Stem Cells. In: Methods Mol Biol. SpringerLink, 31-42, 2018.
Grant & Contract Support
| Title: | Mechanisms of DHA and EPA differential effects on colon cancer chemoprevention |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | PPAR-delta regulation of Wnt-B-catenin to drive colon cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | 15-LOX-1 Regulation of Resolving Generation to Modulate Colon Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | ω-3 fatty acid-derived mediators promote resolution of inflammation: Uncovering new strategies for preventing colitis-associated colon cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | ALOX15 regulation of colon cancer invasiveness via PI3P-linoleic acid metabolism |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Molecular understanding and targeting of determinant factors in gastric tumorigenesis |
| Funding Source: | National Institutes of Health – NIH |
| Role: | Principal Investigator |
| Title: | 15-LOX-1 modulation of colon cancer promotion by linoleic acid |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Interrogating and targeting tumor–stroma interactions in pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | The critical role of PPAR-d in gastric inflammation and carcinogenesis |
| Funding Source: | TMC DDC foundation |
| Role: | Principal Investigator |
| Title: | Targeting PPAR-d alteration and immune suppression for gastric cancer prevention and therapy |
| Funding Source: | NIH |
| Role: | Principal Investigator |
| Title: | Molecularly dissecting the interaction of PPAR-d and Helicobacter infection in gastric tumorigenesis |
| Funding Source: | IRG |
| Role: | Principal Investigator |