Xiangsheng Zuo, M.D., Ph.D.
Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine
About Dr. Zuo
I am a senior cancer research scientist with an extensive laboratory and animal research experience. My research has been utilizing patient tissue samples, and specific mouse models of gastric, colorectal, and pancreatic cancers to understand the role and molecular mechanisms of determining factors in gastrointestinal tumorigenesis. I am particularly interested in investigating whether and how the transcription factor PPARD interacts with helicobacter infection to transform the gastric stem cells and subsequentially drive gastric tumorigenesis.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Gastrointestinal (GI) Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
15-Lipoxygenase Colon Cancer Colonic Tumorigenesis Chemoprevention
Education & Training
Degree-Granting Education
| 2001 | Shanghai Jiao-Tong University Medical School, Shanghai, CHN, PHD, Endocrinology |
| 1990 | Anhui Medical University, Anhui, CHN, MS, Pathophysiology |
| 1987 | Bengbu Medical College, Anhui, CHN, MD, Medicine |
Experience & Service
Academic Appointments
Assistant Professor, Department of Clinical Cancer Prevention, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2011
Instructor, Department of Clinical Cancer Prevention, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2010
Postdoctoral Fellow, Department of Clinical Cancer Prevention, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2002 - 2006
Associate Professor, First Affiliated Hospital of Anhui Medical University, Hefei, 1996 - 2001
Assistant Professor, First Affiliated Hospital of Anhui Medical University, Hefei, 1993 - 1996
Instructor, First Affiliated Hospital of Anhui Medical University, Hefei, 1990 - 1993
Other Appointments/Responsibilities
Departmental Faculty Search Committee Member, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - 2011
Selected Publications
Peer-Reviewed Articles
- Liu Y, Deguchi Y, Wei D, Liu F, Moussalli MJ, Deguchi E, Li D, Wang H, Valentin LA, Colby JK, Wang J, Zheng X, Ying H, Gagea M, Ji B, Shi J, Yao JC, Zuo X, Shureiqi I. Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. Nat Commun 13(1):2665, 2022. e-Pub 2022. PMID: 35562376.
- Yang P, Zuo X, Advani S, Wei B, Malek J, Day RS, Shureiqi I. Celecoxib Colorectal Bioavailability and Chemopreventive Response in Familial Adenomatous Polyposis Patients. Cancer Prev Res (Phila) 15(4):217-223, 2022. e-Pub 2021. PMID: 34610992.
- Kapalczynska M, Lin M, Maertzdorf J, Heuberger J, Muellerke S, Zuo X, Vidal R, Shureiqi I, Fischer AS, Sauer S, Berger H, Kidess E, Mollenkopf H, Tacke F, Meyer TF, Sigal M.. BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation. Nature Communications, 2022.
- Pudakalakatti S, Titus M, Enriquez JS, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci 23(3), 2022. e-Pub 2022. PMID: 35163565.
- Wei D, Wang L, Zuo X, Bresalier RS. Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer. Cancers (Basel) 13(11), 2021. e-Pub 2021. PMID: 34072725.
- Liu Y, Deguchi Y, Wei D, Moussalli MJ, Li D, Wang H, Valentin LA, Colby JK, Liu F, Wang J, Zheng X, Ji B, Yao JC, Zuo X, Shureiqi I. Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant Kras Mice. Cold Spring Harbor Laboratory, 2020. e-Pub 2020.
- Liu F, Zuo X, Liu Y, Deguchi Y, Moussalli MJ, Chen W, Yang P, Wei B, Tan L, Lorenzi PL, Gao S, Jaoude JC, Mehdizadeh A, Valentin LA, Wei D, Shureiqi I. Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P. Cell Rep 32(7):108049, 2020. PMID: 32814052.
- Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris JS, Broaddus R, Zuo X*, Shureiqi I*.. Pleotropic effects of PPARD accelerate colorectal tumorigenesis, progression, and invasion. Cancer Res 79(5):954-969, 2019. PMID: 30679176.
- Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and interferon gamma promote transformation of gastric progenitor cells and tumorigenesis in mice. Gastroenterology 157(1), 2019. PMID: 30885780.
- Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I. The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. Int J Mol Sci 19(11), 2018. e-Pub 2018. PMID: 30373124.
- Wang L, Zuo X, Xie K, Wei D.. The Role of CD44 and Cancer Stem Cells. Methods Mol Biol 1692:31-42, 2018. PMID: 28986884.
- Tian R, Zuo X, Jaoude J, Mao F, Colby J, Shureiqi I. ALOX15 as a suppressor of inflammation and cancer: Lost in the link. Prostaglandins Other Lipid Mediat 132:132:77-83, 2017. e-Pub 2017. PMID: 28089732.
- Xie VK, Li Z, Yan Y, Jia Z, Zuo X, Ju Z, Wang J, Du J, Xie D, Xie K, Wei D. DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression. Clin Cancer Res 23(18):5585-5597, 2017. e-Pub 2017. PMID: 28659310.
- Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I. Metastasis regulation by PPARD expression in cancer cells. JCI Insight 12(1):e91419. doi: 10.1172/jci.insight.91419, 2017. e-Pub 2017. PMID: 28097239.
- Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res 76(8):2419-31, 2016. e-Pub 2016. PMID: 26880805.
- Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell 29(3):324-38, 2016. PMID: 26977883.
- Yan Y, Zuo X, Wei D. Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target. Stem Cells Transl Med 4(9):1033-43, 2015. e-Pub 2015. PMID: 26136504.
- Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli MJ, Elias E, Li HS, Watowich SS, Shureiqi I. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J 29(6):2359-70, 2015. e-Pub 2015. PMID: 25713055.
- Wu Y, Mao F, Zuo X, Moussalli MJ, Elias E, Xu W, Shureiqi I. 15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1α expression in human colon cancer cells. Cancer Med 3(3):472-84, 2014. e-Pub 2014. PMID: 24634093.
- Zuo X, Xu M, Yu J, Wu Y, Moussalli MJ, Manyam GC, Lee SI, Liang S, Gagea M, Morris JS, Broaddus RR, Shureiqi I. Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression. J Natl Cancer Inst 106(4):dju052, 2014. e-Pub 2014. PMID: 24681603.
- Zuo X, Shureiqi I. Eicosanoid profiling in colon cancer: Emergence of a pattern. Prostaglandins Other Lipid Mediat 104-105:139-43, 2013. e-Pub 2012. PMID: 22960430.
- Xu M, Zuo X, Shureiqi I. Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: How to aim?. Biochem Pharmacol 85(5):607-11, 2013. e-Pub 2012. PMID: 23041232.
- Zuo X, Peng Z, Wu Y, Moussalli MJ, Yang XL, Wang Y, Parker-Thornburg J, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice. J Natl Cancer Inst 104(9):709-16, 2012. e-Pub 2012. PMID: 22472308.
- Moussalli MJ, Wu Y, Zuo X, Yang XL, Wistuba II, Raso MG, Morris JS, Bowser JL, Minna JD, Lotan R, Shureiqi I. Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion. Cancer Prev Res (Phila) 4(12):1961-72, 2011. e-Pub 2011. PMID: 21881028.
- Il Lee S, Zuo X, Shureiqi I. 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?. Cancer Metastasis Rev 30(3-4):481-91, 2011. PMID: 22037943.
- Shureiqi I, Chen D, Day RS, Zuo X, Hochman FL, Ross WA, Cole RA, Moy O, Morris JS, Xiao L, Newman RA, Yang P, Lippman SM. Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis. Cancer Prev Res (Phila) 3(7):829-38, 2010. e-Pub 2010. PMID: 20570882.
- Moussalli M, Lotan R, Zuo X, Wu Y, Logsdon C, Morris JS Shureiqi. Ubiquitous Loss of 15-Lipoxygenase-1 Expression in Cancer Cells and Terminal Cell Differentiation Evasion (under revision). Cancer Research, 2010.
- Zuo X, Peng Z, Moussalli MJ, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. J Natl Cancer Inst 101(10):762-7, 2009. e-Pub 2009. PMID: 19436036.
- Zuo X, Morris JS, Broaddus R, Shureiqi I. 15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells. Oncogene 28(12):1496-505, 2009. e-Pub 2009. PMID: 19198625.
- Zuo X, Morris JS, Shureiqi I. Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells. J Biol Chem 283(46):31341-7, 2008. e-Pub 2008. PMID: 18799463.
- Zuo X, Shen L, Issa JP, Moy O, Morris JS, Lippman SM, Shureiqi I. 15-Lipoxygenase-1 transcriptional silencing by the DNA methyltransferase-1 independently of DNA methylation. FASEB J 22(6):1981-92, 2008. e-Pub 2008. PMID: 18198215.
- Shureiqi I, Zuo X, Broaddus R, Wu Y, Guan B, Morris JS, Lippman SM. The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer. FASEB J 21(3):743-53, 2007. e-Pub 2006. PMID: 17167069.
- Zuo X, Wu Y, Morris JS, Stimmel JB, Leesnitzer LM, Fischer SM, Lippman SM, Shureiqi I. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. Oncogene 25(8):1225-1241, 2006. PMID: 16288226.
- Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci U S A 100(17):9968-9973, 2003. e-Pub 2003. PMID: 12909723.
- Zuo X, Li G, Luo T, Li J, Liu Y, Sun W, and Luo M.. Differentiation of NIH3T3 fibroblasts into adipocytes induced by PPAR2 expression. Chin J Intern Med 40:247-250, 2001. PMID: 11798586.
- Zuo X, Li G, Ding W, Luo T, Li J, Xiu Y, Sun W, and Luo M.. The expression of mouse peroxisome proliferator activated receptor 2(mPPAR2) in NIH3T3 cells mediated by the recombinant retrovirus. Chin J Endocrinol Metab 17:175-177, 2001.
- Zuo X, Li G, Ding W, Luo T, Li J, Xiu Y, Sun W, and Luo M.. Study of differentially expressed genes in adipocyte differentiation induced by PPAR2 by using differential display PCR (DD-PCR). Acta Shanghai Second Med Univ 21:404-407, 2001.
- Zuo X, Li G, Luo T, Li J, Xiu Y, Sun W, and Luo M.. Differentiation of NIH3T3 fibroblasts into adipocytes induced by PPAR2 expression [in English]. Chin Med J 114(9):916-920, 2001. PMID: 11780381.
- Zuo X, Li G, Luo T, Li J, Xiu Y, Sun W, Luo M. Molecular cloning of mouse peroxisome proliferator activated receptor 2(mPPAR2) and Characterization of its expressing product in eukaryotic cells. Chin J Endocrin Metab 17:181-183, 2001.
- Zuo X, Luo M. Advances in nuclear transcription factor PPAR (a review). Endocrinology 20:113-116, 2000.
Abstracts
- Moussalli M, Wu Y, Zuo X, Yang XL, Wistuba II, Raso MG, Morris JS, Bowser JL, Minna JD, Lotan R, Shureiqi S. Terminal Cell Differentiation Evasion in Cancer Cells through Ubiquitous 15-Lipoxygenase-1 Expression Loss. 12th International Conference of Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases, 2011.
- Shureiqi I, Chen D, Day R, Zuo X, Hochman F, Ross W, Cole R, Moy O, Morris J, Xiao L, Newman R, Yang P, Lippman S. Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis. Proceedings of the AACR 2010 Annual Meeting, Washington, DC, 2010.
- Zuo X, Morris JS, Shureiqi I. Dimethyl-histone H3 lysine 9 and 15-LOX-1 promoter transcription activation in colon cancer cells. Center for Epigenetics Retreat, The University of Texas M. D. Anderson Cancer Center, 2010.
- Zuo X, Morris JS, Shureiqi. 15-Lipoxygenase-1 Transcription Suppression via the NuRD Complex in Colon Cancer Cells. Proceedings of the Texas Medical Center Cancer Epigenome Workshop, The University of Texas M. D. Anderson Cancer Center, 2009.
- Zuo X, Morris JS, Shureiqi I. Chromatin modification requirements for 15-LOX-1 transcriptional reactivation in colon cancer cells. Proceedings of the 2009 AACR Annual Meeting, Denver, CO, 2009.
- Zuo X, Morris J, Shureiqi I. Chromatin modification requirements for 15-LOX-1 transcriptional reactivation in colon cancer cells. Center for Cancer Epigenetics Retreat, 2008.
- Zuo X, Morris JS, Shureiqi I. Chromatin Remodeling in 15-Lipoxygenase-1 Promoter Is Critical to 15-LOX-1 Transcription Activation. Proceedings of the AACR 2008 Annual Meeting, San Diego, CA, 2008.
- Zuo X, Shen L, Issa JP, Moy O, Morris JS, Shureiqi I. The DNA methyltransferase-1 requirement for transcriptional silencing. AACR, San Diego, 2008.
- Zuo X, Shureiqi I, Broaddus R, Wu Y, Guan B, Morris JS, Lippman SM. The transcriptional factor GATA-6 overexpression and the 15-lipoxygenase-1 silencing in colorectal cancer cells. Proceedings of "Colorectal Cancer: Celebrating a Career in Cancer Prevention," a symposium honoring Bernard Levin, MD, Vice President and Division Head of The University of Texas M. D. Anderson Cancer Center, Division of Cancer Prevention, 2007.
- Zuo X, Shureiqi I, Broaddus R, Wu Y, Guan B, Morris JS, Lippman SM. Contribution of the transcriptional factor GATA-6 overexpression to the 15-lipoxygenase-1. Proceedings of the 2007 AACR Annual Meeting, Los Angeles, CA, 2007.
- Zuo X, Wu, Y, Morris J, Stimmel J, Leesnitzer L, Fischer S, Lippman S, Shureiqi I. 15-Lipoxygenase-1 Modulated PPAR-delta Suppression of PPAR-gamma in Colorectal Cancer Cells. The Proceeding of the 2006 AACR Annual Meeting, Washington, DC, 2006.
- Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan H, Fischer SM, Lippman SM. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid induces apoptosis via downregulation of PPARdelta in colorectal cancer cells. Proceedings of the 2005 AACR Annual Meeting, Anaheim, CA, 2005.
Book Chapters
- Wang L, Zuo X, Xie K, Wei D. The Role of CD44 and Cancer Stem Cells. In: Methods Mol Biol. SpringerLink, 31-42, 2018.
Grant & Contract Support
| Title: | 15-LOX-1 Effects on Colitis and Colon Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Mechanisms of DHA and EPA differential effects on colon cancer chemoprevention |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | PPAR-delta regulation of Wnt-B-catenin to drive colon cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
| Title: | Molecular targeting of 15-LOX-1 for colorectal cancer chemoprevention |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | |
| Funding Source: | American Institute for Cancer Research (AICR) |
| Role: | Co-Investigator |
| Title: | Molecular targeting PPAR-delta for gastric cancer chemoprevention |
| Funding Source: | IRG/MDACC |
| Role: | Principal Investigator |
| Title: | 15-LOX-1 Regulation of Resolving Generation to Modulate Colon Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Molecular targeting PPAR-delta in colon cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | ω-3 fatty acid-derived mediators promote resolution of inflammation: Uncovering new strategies for preventing colitis-associated colon cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | The critical role of PPAR-d in gastric inflammation and carcinogenesis |
| Funding Source: | TMC DDC foundation |
| Role: | Principal Investigator |
| Title: | ALOX15 regulation of colon cancer invasiveness via PI3P-linoleic acid metabolism |
| Funding Source: | NIH/NCI Subcontract with University of Michigan |
| Role: | Subrecipient Principal Investigator |
| Title: | Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Molecular Dissection of host–environment interaction in gastric tumorigenesis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Interrogating and targeting tumor–stroma interactions in pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |