Xiaoping Sun, M.D., Ph.D.
Department of Laboratory Medicine, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Professor, Department of Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1994 | Combined PhD Program of Catholic University of Nijmegen, Nijmegen, The Netherlands, and Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, CHN, PHD, Molecular Genetics |
| 1989 | Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, CHN, MS, Molecular and Cellular Biology |
| 1984 | Zhejiang Medical University, Hangzhou, CHN, MD, Medicine |
Postgraduate Training
| 2007-2008 | Faculty Leadership Academy (54 hours), The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2005-2005 | The Heart of Leadership: Core Skill Program (16 hours), The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2002-2003 | Fellow, Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 1998-2002 | Resident, Anatomical and Clinical Pathology, Department of Pathology, Northwestern University Medical School, Chicago, IL |
| 1994-1998 | Postdoctoral fellow and research associate, The Salk Institute for Biological Studies, La Jolla, CA |
Board Certifications
| 2003 | Hematology, The American Board of Pathology |
| 2002 | Anatomic Pathology and Clinical Pathology, The American Board of Pathology |
Experience & Service
Academic Appointments
Associate Professor, Department of Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - 2015
Assistant Professor, Department of Laboratory Medicine, Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, 2003 - 2009
Administrative Appointments/Responsibilities
Cultural Principles Working Group, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2005 - 2010
General Laboratory Software Project Team, The University of Texas M. D. Anderson Cancer Center, Houston, 2005 - 2010
JCAHO Key Contact Physician, Department of Pathology/Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - 2010
Other Appointments/Responsibilities
Judge for Presentation Award, Texas Chapter, Society of Chinese Bioscientists in America, Houston, TX, 2016 - 2016
Physician, internal medicine, Zhejiang Medical University, Hangzhou, 1984 - 1986
Institutional Committee Activities
elected member, PRS Budget & Finance Committee, 2017 - Present
Committee Member, Credentials Committee of the Medical Staff, 2011 - 2014
Member, The Center for Stem Cell and Developmental Biology, 2011 - Present
Member, Center for Biological Pathways, 2010 - Present
Study Section, University of Texas M.D. Anderson Cancer Center Institutional Research Grant, 2007 - 2010
Steering Committee Member, Hematopathology Tissue Bank, 2003 - Present
Honors & Awards
| 2010 | American Cancer Society Research Scholar |
| 2005 | Physician Scientist Program Award, University of Texas M. D. Anderson Cancer Center |
| 2002 | Fellow Research Award, Division of Pathology and Laboratory Medicine, University of Texas M. D. Anderson Cancer Center |
| 2001 | Goldberg Family Charitable Trust (GFCT) Travel Award, Northwestern Memorial Hospital, Chicago, Illinois |
| 1996 | Research Postdoctoral Fellowship Award, National Institute of Health, USA |
| 1993 | Research Fellowship Award, Max-Plank-Gesellschaft, Germany |
| 1991 | Research Fellowship Award, Deutsche Forschungsgemeinschaft, Germany |
| 1990 | Research Scholarship Award, Koninklijke Nederlandse Akademic van Wetenschappen, The Netherlands |
| 1984 | National Medical Examination Award, Health Department of P. R. China |
| 1979 | Honors Student (top 5%), yearly, Zhejiang Medical University |
Selected Publications
Peer-Reviewed Articles
- Mu C, Wu X, Ma H, Tao W, Zhang G, Xia X, Shen J, Mai J, Sun T, Sun X, Arlinghaus RB, Shen H. Effective Concentration of a Multikinase Inhibitor within Bone Marrow Correlates with In Vitro Cell Killing in Therapy-Resistant Chronic Myeloid Leukemia. Mol Cancer Ther 15(5):899-910, 2016. e-Pub 2016. PMID: 26846820.
- Chakraborty S, Leng, Xiaohong, Perazzona B, Sun X, Lin YH, Arlinghaus RB.. Combination of Jak2 and HSP90 inhibitors: an effective therapeutic option in chronic myelogenous leukemia. Genes & Cancer 7(5-6):201-8, 2016.
- Liu H, Sun X. Pleomorphic plasma cell leukemia. Blood 126(21):2436, 2015. PMID: 26904765.
- Yang L, Zhang S, George SK, Teng R, You X, Xu M, Liu H, Sun X, Amin HM, Shi W. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget 6(17):14953-69, 2015. PMID: 25879451.
- Mallampati S, Leng X, Ma H, Zeng J, Li J, Wang H, Lin K, Lu Y, Yang Y, Sun B, Gong Y, Lee JS, Konopleva M, Andreeff M, Arlinghaus RB, Cai Z, Fang B, Shen H, Han X, Hirsch-Ginsberg CF, Gao X, Paranjape AN, Mani SA, Clise-Dwyer K, Sun X. Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL acute lymphoblastic leukemia. Blood 125(19):2968-73, 2015. e-Pub 2015. PMID: 25712988.
- Wang C, Xia M, Sun X, He Z, Hu F, Chen L, Bueso-Ramos CE, Qiu X, Yin CC.. IGK with conserved IGKV/IGKJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration. Oncotarget 6(37):29062-72, 2015. e-Pub 2015.
- Huang X, Cao M, Wang L, Wu S, Liu X, Li H, Zhang H, Wang RY, Sun X, Wei C, Baggerly KA, Roth JA, Wang M, Swisher SG, Fang B. Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380. Oncotarget 6(1):345-54, 2015. PMID: 25514600.
- Wu S, Wang L, Huang X, Cao M, Hu J, Li H, Zhang H, Sun X, Meng QH, Hofstetter WL, Roth JA, Swisher SG, Fang B. Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380. Bioorg Med Chem 22(19):5234-40, 2014. e-Pub 2014. PMID: 25182964.
- Mallampati S, Sun B, Lu Y, Ma H, Gong Y, Wang D, Lee JS, Lin K, Sun X. Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1ε. Blood 123(26):4064-76, 2014. e-Pub 2014. PMID: 24786772.
- Huang J, Sun X, Gong X, He Z, Chen L, Qiu X, Yin CC. Rearrangement and expression of immunoglobulin μ chain gene in human myeloid cells. Cellular & Molecular Immunology 11:94-104, 2014.
- Ma H, Mallampati S, Lu Y, Sun B, Wang E, Leng X, Gong Y, Shen H, Yin CC, Jones D, Amin HM, You MJ, Zweidler-McKay P, Ma Y, Kantarjian HM, Arlinghaus RB, Glassman A, Sun X. Sox4/Tcf7l1 Axis Is Essential for Initiation and Progression of p190 BCR-ABL+ Acute Lymphoblastic Leukemia. Haematologica 99(10):1591-1598, 2014.
- Zhang YH, Liu J, Dawlett M, Guo M, Sun X, Gong Y. The role of SOX11 immunostaining in confirming the diagnosis of mantle cell lymphoma on fine-needle aspiration samples. Cancer Cytopathol 122(12):892-7, 2014. e-Pub 2014. PMID: 25056830.
- Ma H, Sun H, Sun X. Survival improvement by decade of patients aged 0-14 years with acute lymphoblastic leukemia: a SEER analysis. Sci Rep 4:4227, 2014. e-Pub 2014. PMID: 24572378.
- Wang C, Xia M, Sun X, He Z, Hu F, Chen L, Bueso-Ramos CE, Qiu X, Yin CC.. IGK with conserved IGKV/IGKJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration 6(36):29062-72, 2014.
- Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro-B cells. J Immunol 190(5):2080-9, 2013. e-Pub 2013. PMID: 23345330.
- Qui X, Sun X, He Z, Huang J, Hu F, Chen L, Lin P, You J, Medeiros J, and Yin C. Immunoglobulin gamma chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia. Leukemia 27:92-9, 2013.
- Yang Y, Mallampati S, Sun B, Zhang J, Gong Y, Cai Z, Sun X. Protection of ALL Cells by Bone Marrow Stromal Cells and the Underlying Molecular Mechanism. Cancer Letters 333:9-17, 2013.
- Yu Z, Sun B, Kantarjian HM, Keating MJ, Amin HM, Sun X. Protein expression profiling of cytokines and cytokine receptors on purified chronic lymphocytic leukemia cells from patients with favourable prognostic indicators. Leuk Lymphoma 49(4):751-6, 2008. PMID: 18398743.
- Sun X, Zhang W, Ramdas L, Stivers DN, Jones DM, Kantarjian HM, Estey EH, Vadhan-Raj S, Medeiros LJ, Bueso-Ramos CE. Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping. Mod Pathol 20(8):811-20, 2007. e-Pub 2007. PMID: 17571080.
- Mallampati S, Zeng J, Li J, Patchva S, Vijay GV, Gong Y, Konopleva M, Fang B, Shen H, Han X, Hirsch-Ginsberg CF, Hawke DH, Clise-Dwyer K, Mani SA, Sun X.. p38 MAPK inhibitors prevent mesenchymal stem cell–mediated tyrosine kinase inhibitor resistance in BCR-ABL+ ALL. Blood.
Abstracts
- Mallampati S, Zeng J, Li J, Sun X.. Targeting IL-7/IL-7R pathway to overcome TKI-induced MSC-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia. International Journal of Molecular Medicine 36:supplement, 2015.
- Zhang YH, Liu J, Dawlett M, Guo M, Sun X, Gong Y. The role of SOX11 immunostaining in confirming the diagnosis of mantle cell lymphoma on fine-needle aspiration samples. Modern Pathology, 2014.
- Harutyunyan KG, Nwajei F, Zal MA, Fruman DA, Mallampati S, Sun X, Zal T, Konopleva M.. The Dynamics of Stroma-Leukemia Interaction in the Hypoxic BM Niches in Vivo. Blood 124:2396, 2014.
Grant & Contract Support
| Title: | "Role of Sox4 in Human Leukemia". Physician Scientist Program Award |
| Funding Source: | University of Texas M. D. Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | "Role of Sox4 in the interaction between leukemic cells and their niches" |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Principal Investigator |
| Title: | "Study Sox4 regulated genes in B cell development in a novel in vitro system" |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | "Target both BCR ABL and MSC mediated signaling in BCR ABL ALL" |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified February 18, 2020