Xiuning Le, M.D., Ph.D.
Department of Thoracic Head and Neck Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Thoracic/Head and Neck Medical Oncology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2010 | Harvard Medical School, Boston, MA, USA, PHD, Biological and Biomedical Sciences |
| 2003 | Peking Union Medical College, Beijing, CHN, MD, Clinical Medicine |
Postgraduate Training
| 2014-2017 | Research Fellowship, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA |
| 2013-2016 | Clinical Fellowship, Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA |
| 2010-2013 | Clinical Residency, Internal Medicine, University of Massachusetts Medical Center, Worcester, MA |
Board Certifications
| 2016 | American Board Internal Medicine, Medical Oncology |
| 2013 | American Board Internal Medicine, Internal Medicine |
Experience & Service
Academic Appointments
Instructor, Department of Hematology Oncology, Division of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 2016 - 2017
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Rangachari D, Le, X, Shea M, Huberman MS, VanderLaan PA, Kobayashi SS, Costa DB. Cases of ALK-Rearranged Lung Cancer with 5-Year Progression-Free Survival with Crizotinib as Initial Precision Therapy. J Thorac Oncol 12(11):e175-e177, 2017. e-Pub 2017. PMID: 28611010.
- Le, X, Rangachari D, Costa DB. Moving more potent and less toxic options to the frontline in the management of advanced lung cancer. J Thorac Dis 9(9):2812-2818, 2017. PMID: 29221246.
- Rangachari D, VanderLaan PA, Shea M, Le, X, Huberman MS, Kobayashi SS, Costa DB. Correlation between Classic Driver Oncogene Mutations in EGFR, ALK, or ROS1 and 22C3-PD-L1 =50% Expression in Lung Adenocarcinoma. J Thorac Oncol 12(5):878-883, 2017. e-Pub 2017. PMID: 28104537.
- Le, X, Antony R, Razavi P, Treacy DJ, Luo F, Ghandi M, Castel P, Scaltriti M, Baselga J, Garraway LA. Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer. Cancer Discov 6(10):1134-1147, 2016. e-Pub 2016. PMID: 27604488.
- Le, X, Freed JA, VanderLaan PA, Huberman MS, Rangachari D, Jorge SE, Lucena-Araujo AR, Kobayashi SS, Balasubramanian S, He J, Chudnovsky Y, Miller VA, Ali SM, Costa DB. Detection of Crizotinib-Sensitive Lung Adenocarcinomas With MET, ALK, and ROS1 Genomic Alterations via Comprehensive Genomic Profiling. Clin Lung Cancer 16(5):e105-9, 2015. e-Pub 2015. PMID: 25922291.
- Le, X, Desai NV, Majid A, Karp RS, Huberman MS, Rangachari D, Kent MS, Gangadharan SP, Folch E, VanderLaan PA, Costa DB. De novo pulmonary small cell carcinomas and large cell neuroendocrine carcinomas harboring EGFR mutations: Lack of response to EGFR inhibitors. Lung Cancer 88(1):70-3, 2015. e-Pub 2015. PMID: 25700797.
- Rangachari D, VanderLaan PA, Le, X, Folch E, Kent MS, Gangadharan SP, Majid A, Haspel RL, Joseph LJ, Huberman MS, Costa DB. Experience with targeted next generation sequencing for the care of lung cancer: insights into promises and limitations of genomic oncology in day-to-day practice. Cancer Treat Commun 4:174-181, 2015. PMID: 26601054.
- Jain P, Le, X, Young KH, Patel KP, Wang S, Pei L, Barron LL, Abruzzo L, O'Brien S. Sequential lymphomas or clonally unrelated richter syndrome of chronic lymphocytic leukemia into mantle cell lymphoma. Clin Lymphoma Myeloma Leuk 13(5):606-9, 2013. e-Pub 2013. PMID: 23763914.
- Le, X, Pugach EK, Hettmer S, Storer NY, Liu J, Wills AA, DiBiase A, Chen EY, Ignatius MS, Poss KD, Wagers AJ, Langenau DM, Zon LI. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development 140(11):2354-64, 2013. e-Pub 2013. PMID: 23615277.
- Le, X, Jain P, O'Brien S. Aspergillus pseudomembranous necrotizing tracheitis. Am J Hematol 88(3):242, 2013. e-Pub 2012. PMID: 23065937.
- Li S, Qiao Y, Di Q, Le, X, Zhang L, Zhang X, Zhang C, Cheng J, Zong S, Koide SS, Miao S, Wang L. Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis. Eur J Cell Biol 88(9):509-20, 2009. e-Pub 2009. PMID: 19545932.
- Zon LI, Le, X. Potential of zebrafish for anticancer drug screening. Expert Opin Drug Discov 3(12):1451-60, 2008. PMID: 23506108.
- Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le, X, Goessling W, Neuberg DS, Kunkel LM, Zon LI. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev 21(11):1382-95, 2007. e-Pub 2007. PMID: 17510286.