Yalong Wang, PhD
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Instructor, Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Instructor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2015 | Chinese Academy of Sciences, Beijing, Beijing, CN, Cell Biology, PhD |
| 2010 | Shanghai Jiaotong University, Shanghai, Shanghai, CN, Animal Science, BS |
Postgraduate Training
| 2019-2023 | Postgraduate Fellow, Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2017-2019 | Postgraduate Fellow, Immunology, University of Science and Technology of China, Shanghai, Shanghai |
Honors & Awards
| 2022 | EMC Travel Award, The University of Texas MD Anderson Cancer Center |
| 2013 | National Scholarship Excellence Award, University of Chinese Academy of Sciences |
Selected Publications
Peer-Reviewed Articles
- Wang, Y, Zhou, J, He, W, Fu, R, Shi, L, Dang, NK, Liu, B, Xu, H, Cheng, X, Bedford, MT. SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Cell Reports 43(7), 2024. e-Pub 2024. PMID: 38985674.
- Li, Y, Dobrolecki, LE, Sallas, C, Zhang, X, Kerr, TD, Bisht, D, Wang, Y, Awasthi, S, Kaundal, B, Wu, S, Peng, W, Mendillo, ML, Lu, Y, Jeter, CR, Peng, G, Liu, J, Westin, SN, Sood, AK, Lewis, MT, Das, J, Yi, S, Bedford, MT, McGrail, DJ, Sahni, N. PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition. Cell Reports Medicine 4(12), 2023. e-Pub 2023. PMID: 38118413.
- Wright T, Wang Y, Stratton SA, Sebastian M, Liu B, Johnson DG, Bedford MT. Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma. Biochem J 480(22):1805-1816, 2023. e-Pub 2023. PMID: 37905668.
- Wang Y, Bedford MT. Effectors and effects of arginine methylation. Biochem Soc Trans 51(2):725-734, 2023. e-Pub 2023. PMID: 37013969.
- Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W. CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Cell Rep 42(4):112316, 2023. e-Pub 2023. PMID: 36995937.
- Liu Y, Iqbal A, Li W, Ni Z, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, Qin S, Loppnau P, Jiang H, Guo X, Brown PJ, Zhen X, Xu G, Mekhail K, Ji X, Bedford MT, Greenblatt JF, Min J. A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun 13(1):5453, 2022. e-Pub 2022. PMID: 36114190.
- Iannelli G, Milite C, Marechal N, Cura V, Bonnefond L, Troffer-Charlier N, Feoli A, Rescigno D, Wang Y, Cipriano A, Viviano M, Bedford MT, Cavarelli J, Castellano S, Sbardella G. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem 65(17):11574-11606, 2022. e-Pub 2022. PMID: 35482954.
- Wang Y, Person MD, Bedford MT. Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens. Methods 200:80-86, 2022. e-Pub 2022. PMID: 34107353.
- Fu R, He W, Dou J, Villarreal OD, Bedford E, Wang H, Hou C, Zhang L, Wang Y, Ma D, Chen Y, Gao X, Depken M, Xu H. Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Nat Commun 13(1):474, 2022. e-Pub 2022. PMID: 35078987.
- Wright T, Wang Y, Bedford MT. The Role of the PRMT5-SND1 Axis in Hepatocellular Carcinoma. Epigenomes 5(1), 2021. e-Pub 2021. PMID: 33768972.
- Wang Y, He K, Sheng B, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H, Li HB, Flavell RA, Zhu S. The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells. Proc Natl Acad Sci U S A 118(4), 2021. e-Pub 2021. PMID: 33483420.
- Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res 22(5):836-47, 2012. e-Pub 2012. PMID: 22491475.
Other Articles
- Wan T, Wang Y, He K, Zhu S Microbial sensing in the intestine. Protein Cell 14(11):824-860, 2023. PMID: 37191444.
Selected Presentations & Talks
Local Presentations
- 2024. SART3 reads methylarginine marked GAR motifs. Poster. Center for Cancer Epigenetics Retreat (CCE’24). Houston, Texas, US.
- 2023. SART3 is a Novel Rme2s Reader. Poster. Center for Cancer Epigenetics Retreat. Houston, Texas, US.
- 2022. Role of SND1 in pancreas homeostasis. Poster. Center for Cancer Epigenetics Retreat (CCE’22). Houston, Texas, US.
- 2021. Post-transcriptional and post-translational regulation of E2F1 by SND1 in pancreas homeostasis. Invited. ANNUAL RETREAT Genetics and Epigenetics Program. Houston, Texas, US.
International Presentations
- 2022. Role of SND1 in pancreas homeostasis. Poster. VAI Epigenetics Symposium 20 (+2) Years of the Histone Code. Grand Rapids, US.
Patient Reviews
CV information above last modified March 17, 2025