Yao Yu
Department of Epidemiology, Division of Cancer Prevention and Population Sciences
Present Title & Affiliation
Primary Appointment
Assistant Professor, Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2011 | University Of Chinese Academy of Sciences, China, CN, Bioinformatics, Ph.D |
| 2006 | Shanghai Jiao tong University, Shangai, CN, Bioinformatics, B.S |
Postgraduate Training
| 2026-null | Health Educators Fellowship Program Fellow, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2014-2017 | Postdoc, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 2011-2013 | Postdoc, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China |
Experience & Service
Faculty Academic Appointments
Associate Professor, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China, China, 2013 - 2014
Assistant Professor, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China, 2013 - 2013
Visiting Scientist, Epidemiology, Helmholtz Association of German Research Centre, Munich, 2008 - 2008
Other Professional Positions
Direct of Bioinformatics and Scientific Consulting, ZhongXin Biotechology Shanghai Co., Ltd, Shanghai, 2013 - 2014
Direct of Bioinformatics, Encodegenomics Biotechnology Co., Ltd, Shanghai, 2011 - 2013
Research Investigator and Software Engineer, SCBIT-IBM-Inforsense Joint Laboratory, Shanghai, 2006 - 2009
Intramural Institutional Committee Activities
Reviewer, DCPPS Employee Recognition Awards Review Board, The University of Texas MD Anderson Cancer Center, 2026
Reviewer, Cancer Prevention Research Training Program (CPRTP) Review Committee, The University of Texas MD Anderson Cancer Center, 2023
Honors & Awards
| 2019 | Nomination for Excellence in Research Support, The University of Texas MD Anderson Cancer Center |
| 2019 | Nomination for Exemplary Employee in Division of Cancer Prevention & Population Sciences, The University of Texas MD Anderson Cancer Center |
| 2012 | Sanofi-Aventis and Shanghai Institutes for Biological Sciences Young Talent Scholarship |
| 2010 | Di Ao Scholarship of Graduate University of Chinese Academy of Sciences |
| 2005 | Excellent Students Scholarship of Shanghai Jiao tong University |
Professional Memberships
Selected Presentations & Talks
International Presentations
- 2024. The Covariate Adjusted PERmutation (CAPER) tool for genetic association analysis. Poster. ASHG Annual Meeting, US.
- 2024. XPAT2: A Quality Control Framework for Sequencing-Based Association Studies in Biobank Scale Data. Poster. ASHG Annual Meeting, US.
- 2024. Accelerating novel gene discovery in nonsyndromic cleft lip/palate using whole genome sequencing. Poster. ASHG Annual Meeting, US.
- 2023. The GOBACK Study: High Molecular Diagnostic Rate in Individuals with Birth Defects and Childhood Caner. Poster. ASHG Annual Meeting, US.
- 2023. Exome-wide assessment of pediatric rhabdomyosarcoma suggests a novel susceptibility gene related to telomere function. Poster. ASHG Annual Meeting, US.
- 2020. Whole exome sequencing case-control study implicates truncating variants in ATM as major risk factors in pancreatic cancer. Conference. American Association for Cancer Research (AACR) Annual Meeting. San Diego, US.
- 2019. X-method Multiple Gene Isoform Test (X-MGIT) in case-control association studies. Conference. IGES Annual Meeting. Houston, US.
- 2019. Aggregating multiple rare variant association tests to enhance gene discovery in rare variant association studies. Conference. ASHG Annual Meeting. Houston, US.
- 2018. Aggregating multiple rare variant association tests to enhance gene discovery in sequence-based association studies. Conference. International Society for Computational Biology (ISMB) Conference. Chicago, US.
- 2018. Whole-exome case-control association to characterize the contribution of rare coding variants to sarcoma susceptibility. Conference. ASHG Annual Meeting. San Diego, US.
- 2018. Identification of disease variants in exomes and genomes. Tutorial Speaker. Conference. ISMB 2018 Conference. Chicago, US.
- 2017. Insights into the performance of whole-exome sequencing technologies. Conference. ASHG Annual Meeting. Orlando, US.
- 2017. XPAT: A toolkit to conduct cross-platform association studies with heterogeneous sequencing datasets. Conference. ESHG Annual Meeting. Vienna, AT.
- 2016. Insights into the performance of whole-exome sequencing technologies. Conference. The Biology of Genomes Conference. Cold Springs Harbor, US.
- 2015. Whole-exome case-control association and somatic-germline interaction analyses of five major cancer types. Conference. Huntsman Cancer Institute Special Conference. Salt Lake City, US.
- 2015. Whole-exome case-control association and somatic-germline interaction analyses in melanoma. Conference. American Society of Human Genetics (ASHG) 2015 Annual Meeting. Baltimore, US.
- 2015. A quality control framework for exome sequencing studies to reduce bias from heterogeneous sequencing platforms. Conference. International Genetic Epidemiology Society (IGES) Annual Meeting. Baltimore, US.
Grant & Contract Support
| Date: | 2025 - 2030 |
| Title: | Leveraging whole genome sequencing with functional genomics to enhance nonsyndromic cleft lip/palate (NSCLP) gene discovery |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | R01 DE033908 |
| Date: | 2023 - 2028 |
| Title: | Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric Cancer |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | R01CA284531 |
| Date: | 2023 - 2025 |
| Title: | Molecular epidemiology of acute lymphoblastic leukemia in children with Down syndrome |
| Funding Source: | NHI |
| Role: | Co-I |
| ID: | R01 CA249867 |
| Date: | 2023 - 2027 |
| Title: | Discovery and Characterization of Rare Variant Effects in Dilated Cardiomyopathy via Large-Scale Biobank Analysis |
| Funding Source: | NIH/NHLBI |
| Role: | Co-I |
| ID: | R01 HL167509 |
| Date: | 2022 - 2025 |
| Title: | Leveraging novel methods to improve nonsyndromic cleft lip/palate gene discovery |
| Funding Source: | NIH |
| Role: | Computational Scientist |
| ID: | R03 DE032160 |
| Date: | 2021 - 2026 |
| Title: | Dissecting and Targeting RB1-Mutant Osteosarcoma |
| Funding Source: | UT Health Science Center at Houston-NIH/NCI |
| Role: | Co-I |
| ID: | R01 CA246130 |
| Date: | 2020 - 2023 |
| Title: | Identifying Novel Cancer Predisposition Syndromes: An Integrative Epidemiologic and Genomic Approach |
| Funding Source: | Baylor College of Medicine/DOD |
| Role: | Co-I |
| ID: | W81XWH-20-1-0567 |
| Date: | 2019 - 2023 |
| Title: | Harnessing the power of genetic relatedness for disease gene discovery |
| Funding Source: | NIH/NIGMS |
| Role: | Co-I |
| ID: | R01 GM133169 |
| Date: | 2013 - 2015 |
| Title: | The functional study of RNA editing mode in evolution of insecta |
| Funding Source: | National Natural Science Foundation of China (General Program for Young Scholar) |
| Role: | PI |
| Date: | 2013 - 2014 |
| Title: | The study of regulatory promoter elements in Soybean |
| Funding Source: | National Natural Science Foundation of China |
| Role: | Principal Investigator of subcontract |
| Date: | 2012 - 2013 |
| Title: | The study of the sensitivity of gene regulation modules using cross platform transcriptome data |
| Funding Source: | Chinese Postdoctoral Science Foundation (General Program) |
| Role: | PI |
Selected Publications
Peer-Reviewed Articles
- Tark, JY, Renwick, A, Yu, Y, Sabo, A, Olshan, AF, Plon, SE, Huff, C, Lupo, PJ. Evaluating the Genetic Overlap Between Congenital Heart Disease and Neuroblastoma Risk. Pediatric Blood and Cancer 73(2), 2026. e-Pub 2026. PMID: 41431348.
- Barnes, D, Tyrer, J, Dennis, J, Leslie, G, Bolla, MK, Lush, M, Aeilts, AM, Aittomäki, K, Andrieu, N, Andrulis, IL, Anton-Culver, H, Arason, A, Arun, BK, Balmaña, J, Bandera, EV, Barkardottir, RB, Berger, L, Berrington de Gonzalez, A, Berthet, P, Białkowska, K, Bjørge, L, Blanco, AM, Blok, MJ, Bobolis, K, Bogdanova, NV, Brenton, JD, Butz, H, Buys, SS, Caligo, MA, Campbell, I, Castillo, C, Claes, K, Colonna, S, Cook, LS, Daly, MB, Dansonka-Mieszkowska, A, De La Hoya, M, Defazio, A, DePersia, A, Ding, YC, Doherty, JA, Domchek, SM, Dörk, T, Einbeigi, Z, Engel, C, Evans, G, Foretova, L, Fortner, RT, Fostira, F, Foti, MC, Friedman, E, Frone, MN, Ganz, PA, Gentry-Maharaj, A, Glendon, G, Godwin, AK, González-Neira, A, Greene, MH, Gronwald, J, Guerrieri-Gonzaga, A, Hamann, U, Hansen, TV, Harris, HR, Hauke, J, Heitz, F, Hogervorst, FB, Hooning, MJ, Hopper, JL, Huff, C, Huntsman, DG, Imyanitov, EN, Izatt, L, Jakubowska, A, James, PA, Janavicius, R, John, EM, Kar, S, Karlan, B, Kennedy, C, Kiemeney, L, Konstantopoulou, I, Kupryjanczyk, J, Laitman, Y, Lavie, O, Lawrenson, K, Lester, J, Lesueur, F, Lopez-Pleguezuelos, C, Mai, PL, Manoukian, S, May, T, McNeish, IA, Menon, U, Milne, RL, Modugno, F, Mongiovi, JM, Montagna, M, Moysich, KB, Neuhausen, SL, Nielsen, FC, Nogues, C, Oláh, E, Olopade, OI, Osorio, A, Papi, L, Pathak, HB, Pearce, CL, Pedersen, IS, Peixoto, A, Pejovic, T, Peng, PC, Peshkin, B, Peterlongo, P, Powell, CB, Prokofieva, D, Pujana, MA, Radice, P, Rashid, MU, Rennert, G, Richenberg, G, Sandler, DP, Sasamoto, N, Setiawan, VW, Sharma, P, Sieh, W, Singer, CF, Snape, K, Sokolenko, AP, Soucy, P, Southey, MC, Stoppa-Lyonnet, D, Sutphen, R, Sutter, C, Tan, YY, Teixeira, MR, Terry, KL, Thomsen, LV, Tischkowitz, M, Toland, AE, Van Gorp, T, Vega, A, Edwards, DR, Webb, P, Weitzel, J, Wentzensen, N, Whittemore, AS, Winham, SJ, Wu, AH, Yadav, S, Yu, Y, Ziogas, A, Berchuck, A, Couch, FJ, Goode, EL, Goodman, MT, Monteiro, AN, Offit, K, Ramus, SJ, Risch, HA, Schildkraut, J, Thomassen, M, Simard, J, Easton, D, Jones, MR, Chenevix-Trench, G, Gayther, SA, Antoniou, AC, Pharoah, PD. Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer. npj Genomic Medicine 10(1), 2025. e-Pub 2025. PMID: 41266372.
- Chang, YH, Bresnahan, S, Taylor Head, S, Harrison, TA, Yu, Y, Huff, C, Pasaniuc, B, Lindstrom̈, S, Bhattacharya, A. Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level. British journal of cancer 133(6):874-885, 2025. e-Pub 2025. PMID: 40775447.
- Hahn, AW, Tidwell, R, Pilie, PG, Yu, Y, Liu, J, Surasi, DS, Titus, M, Zhang, J, Venkatesh, N, Panaretakis, T, Gregg, JR, Zurita-Saavedra, A, Siddiqui, BA, Corn, P, Subudhi, SK, Msaouel, P, Koutroumpakis, E, Huff, C, Aparicio, A, McQuade, JL, Frigo, DE, Logothetis, CJ. Body composition as a determinant of the therapeutic index with androgen signaling inhibition. Prostate Cancer and Prostatic Diseases 28(3):802-808, 2025. e-Pub 2025. PMID: 39019979.
- Polikowsky HG, Scartozzi AC, Shaw DM, Pruett DG, Chen H, Petty LE, Petty AS, Lowther EJ, Cho S, Yu Y, Team AR, Mozaffari S, Avery CL, Harris KM, Gordon RL, Beilby JM, Viljoen KZ, Jones RM, Huff CD, Highland HM, Kraft SJ, Below JE. Large-scale genome-wide analyses of stuttering. Nature Genetics 57(8):1835-1847, 2025. e-Pub 2025. PMID: 40721530.
- Kui N, Yu Y, Choi J, McCaw ZR, Li X, Huff C, Sun R. Large Impact of Genetic Data Processing Steps on Stability and Reproducibility of Set-Based Analyses in Genome-Wide Association Studies. bioRxiv, 2025. e-Pub 2025.
- Lawson-Michod KA, Marks JR, Collin LJ, Nix DA, Davidson NR, Huff CD, Yu Y, Atkinson A, Johnson CE, Salas LA, Peres LC, Greene CS, Schildkraut JM, Doherty JA. Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals. AACR Journals, 2025. e-Pub 2025.
- Lawson-Michod, KA, Marks, JR, Collin, LJ, Nix, D, Davidson, NR, Huff, C, Yu, Y, Atkinson, A, Johnson, CE, Salas, LA, Peres, LC, Greene, CS, Schildkraut, J, Doherty, JA. Genomic Characterization of High-Grade Serous Ovarian Carcinoma Reveals Distinct Somatic Features in Black Individuals. Cancer Research 85(9):1725-1737, 2025. e-Pub 2025. PMID: 40063699.
- Yu Y, Feng B, Chang C, Bell R, Wood A, Sturgis E, Li G, Olshan A, Chen C, Lou P, Hsu W, Cessna M, Witt B, Neklason D, Hashibe M, Huff C, Tavtigian S. Exome Sequencing for Head and Neck Cancer Predisposition Genes. medRxiv, 2025. e-Pub 2025.
- Gu, H, Yu, Y, Sisoudiya, SD, Mishra, P, Li, H, Schraw, JM, Scheurer, ME, Muzny, DM, Mitchell, D, Taylor, O, Jhangiani, SN, Dugan, SP, Wu, Y, Doddapaneni, HV, Bhamidipati, S, Gingras, MC, Posey, JE, Gibbs, RA, Huff, C, Plon, SE, Lupo, PJ, Sabo, A. An evaluation of genetic predisposition to congenital anomalies and pediatric cancer supports KAT6B as a novel neuroblastoma susceptibility gene. Genetics in Medicine Open 3, 2025. e-Pub 2025. PMID: 41542347.
- Jain, S, Bakolitsa, C, Brenner, SE, Radivojac, P, Moult, J, Repo, S, Hoskins, RA, Andreoletti, G, Barsky, D, Chellapan, A, Chu, H, Dabbiru, N, Kollipara, NK, Ly, M, Neumann, AJ, Pal, LR, Odell, E, Pandey, G, Peters-Petrulewicz, RC, Srinivasan, R, Yee, SF, Yeleswarapu, SJ, Zuhl, M, Adebali, O, Patra, A, Beer, MA, Hosur, R, Peng, J, Bernard, B, Berry, M, Dong, S, Boyle, AP, Adhikari, A, Chen, J, Hu, Z, Wang, R, Wang, Y, Miller, M, Wang, Y, Bromberg, Y, Turina, P, Capriotti, E, Han, JJ, Ozturk, K, Carter, H, Babbi, G, Bovo, S, Yu, Y, Huff, C, Zee, BC. CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods. Genome biology 25(1), 2024. e-Pub 2024. PMID: 38389099.
- Venkatesh N, Tidwell RS, Yu Y, Aparicio A, Zurita AJ, Subudhi SK, Siddiqui BA, Mukhida SS, Gregg JR, Corn PG, Koutroumpakis E, McQuade JL, Frigo DE, Pilie PG, Huff C, Logothetis CJ, Hahn AW. Body composition in recurrent prostate cancer and the role of steroidogenic genotype. Endocrine-related cancer, 2024. e-Pub 2024.
- Hahn AW, Manyam GC, Chapin BF, Zhang M, Yu Y, Pettaway CA, Chery L, Pisters LL, Ward JF, Gregg JR, Papadopoulos J, Kamat AM, Lozano M, Hoang A, Broom B, Wang X, Huff CD, Logothetis CJ, Troncoso P, Pilié PG, Davis JW. A phase II trial of apalutamide for intermediate-risk prostate cancer and molecular correlates. BJU International 134(3):449-458, 2024. e-Pub 2024. PMID: 38837608.
- Hahn AW, Tidwell RS, Pilie PG, Yu Y, Liu J, Surasi DS, Titus M, Zhang J, Venkatesh N, Panaretakis T, Gregg JR, Zurita AJ, Siddiqui BA, Corn PG, Subudhi SK, Msaouel P, Koutroumpakis E, Huff CD, Aparicio A, McQuade JL, Frigo DE, Logothetis CJ. Body composition as a determinant of the therapeutic index with androgen signaling inhibition. Prostate Cancer and Prostatic Diseases, 2024. e-Pub 2024.
- Aparicio, A, Tidwell, RS, Yadav, SS, Chen, JS, Zhang, M, Liu, J, Guo, S, Pilie, PG, Yu, Y, Song, X, Vundavilli, H, Jindal, S, Zhu, K, Viscuse, PV, Lebenthal, J, Hahn, AW, Soundararajan, R, Corn, P, Zurita-Saavedra, A, Subudhi, SK, Zhang, J, Wang, W, Huff, C, Troncoso, P, Allison, JP, Sharma, P, Logothetis, CJ. A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration-Resistant Prostate Cancer. Clinical Cancer Research 30(13):2751-2763, 2024. e-Pub 2024. PMID: 38683200.
- Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R, Darst BF, Sheng X, Xu Y, Chou AJ, Benlloch S, Dadaev T, Brook MN, Plym A, Sahimi A, Hoffman TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Laisk T, Figuerêdo J, Muir K, Ito S, Liu X, Project BJ, Uchio Y, Kubo M, Kamatani Y, Lophatananon A, Wan P, Andrews C, Lori A, Choudhury PP, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Rentsch CT, Cho K, Mcmahon BH, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder A, Stroomberg HV, Batra J, Chambers S, Horvath L, Clements JA, Tilly W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordstrom T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein S, Cook MB, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, MÉ P, Stanford JL, Ostrander EA, Koutros S, Beane Freeman LE, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Butler EN, Mohler JL, Taylor JA, Kogevinas M, Dierssen-Sotos T, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Pilie P, Yu Y, Bohlender RJ, Gu J, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Brenner H, Chen X, Holleczek B, Schöttker B, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nature Genetics 55(12):2065-2074, 2023. e-Pub 2023. PMID: 37945903.
- Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nature communications 14(1):1694, 2023. e-Pub 2023. PMID: 36973285.
- Li Y, Richard MA, Kachuri L, Yu Y, Hsu CR, Rosser TC, Leslie EJ, Devidas M, Raetz EA, Loh ML, Hunger SP, Eduthan NP, Galbraith MD, Espinosa J, Yang JJ, Sherman SL, Huff CD, Rabin KR, Lupo PJ, de Smith AJ. Heritable Variation in Lymphocyte-Related Traits and Risk of Down Syndrome Acute Lymphoblastic Leukemia: A Mendelian Randomization Study. Blood, 2023. e-Pub 2023.
- Wang A, Xu Y, Yu Y, Nead KT, Kim T, Xu K, Dadaev T, Saunders E, Sheng X, Wan P, Pooler L, Xia LY, Chanock S, Berndt SI, Gapstur SM, Stevens V, Albanes D, Weinstein SJ, Gnanapragasam V, Giles GG, Nguyen-Dumont T, Milne RL, Pomerantz MM, Schmidt JA, Stopsack KH, Mucci LA, Catalona WJ, Hetrick KN, Doheny KF, MacInnis RJ, Southey MC, Eeles RA, Wiklund F, Kote-Jarai Z, de Smith AJ, Conti DV, Huff C, Haiman CA, Darst BF. Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men. Human molecular genetics 32(3):489-495, 2023. e-Pub 2023. PMID: 36018819.
- Strati P, Jallouk AP, Sun R, Choi J, Das K, Cherng HJ, Ahmed S, Lee HJ, Iyer SP, Nair R, Nastoupil LJ, Steiner RE, Huff CD, Yu Y, Mistry H, Pulsifer B, Noorani M, Saini N, Shpall EJ, Kebriaei P, Flowers CR, Westin JR, Hildebrandt MAT, Neelapu SS. Impact of conditioning chemotherapy on lymphocyte kinetics and outcomes in LBCL patients treated with CAR T-cell therapy. Leukemia 36(11):2669-2677, 2022. e-Pub 2022. PMID: 36127509.
- Yu Y, Alvarado R, Petty LE, Bohlender RJ, Shaw DM, Below JE, Bejar N, Ruiz OE, Tandon B, Eisenhoffer GT, Kiss DL, Huff CD, Letra A, Hecht JT. Polygenic risk impacts PDGFRA mutation penetrance in non-syndromic cleft lip and palate. Hum Mol Genet 31(14):2348-2357, 2022. e-Pub 2022. PMID: 35147171.
- Tu J, Huo Z, Yu Y, Zhu D, Xu A, Huang MF, Hu R, Wang R, Gingold JA, Chen YH, Tsai KL, Forcioli-Conti NR, Huang SXL, Webb TR, Su J, Bazer DA, Jia P, Yustein JT, Wang LL, Hung MC, Zhao Z, Huff CD, Shen J, Zhao R, Lee DF. Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies. Proceedings of the National Academy of Sciences of the United States of America 119(16):e2117857119, 2022. e-Pub 2022. PMID: 35412907.
- Yu Y, Chang K, Chen JS, Bohlender RJ, Fowler J, Zhang D, Huang M, Chang P, Li Y, Wong J, Wang H, Gu J, Wu X, Schildkraut J, Cannon-Albright L, Ye Y, Zhao H, Hildebrandt MAT, Permuth JB, Li D, Scheet P, Huff CD. A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk. Human Genetics and Genomics Advances 3(1):100078, 2022. e-Pub 2022. PMID: 35047863.
- Karlsson Q, Brook MN, Dadaev T, Wakerell S, Saunders EJ, Muir K, Neal DE, Giles GG, MacInnis RJ, Thibodeau SN, McDonnell SK, Cannon-Albright L, Teixeira MR, Paulo P, Cardoso M, Huff C, Li D, Yu Y, Scheet P, Permuth JB, Stanford JL, Dai JY, Ostrander EA, Cussenot O, Cancel-Tassin G, Hoegel J, Herkommer K, Schleutker J, Tammela TLJ, Rathinakannan V, Sipeky C, Wiklund F, Grönberg H, Aly M, Isaacs WB, Dickinson JL, FitzGerald LM, Chua MLK, Nguyen-Dumont T, Consortium P, Schaid DJ, Southey MC, Eeles RA, Kote-Jarai Z. Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study. European Urology Oncology 4(4):570-579, 2021. e-Pub 2021. PMID: 33436325.
- Puvvula PK, Yu Y, Sullivan KR, Eyob H, Rosenberg J, Welm A, Huff C, Moon AM. Inhibiting an RBM39/MLL1 epigenomic regulatory complex with dominant-negative peptides disrupts cancer cell transcription and proliferation. Cell Reports 35(9):109156, 2021. e-Pub 2021. PMID: 34077726.
- Song H, Dicks EM, Tyrer J, Intermaggio M, Chenevix-Trench G, Bowtell DD, Traficante N, Group A, Brenton J, Goranova T, Hosking K, Piskorz A, van Oudenhove E, Doherty J, Harris HR, Rossing MA, Duerst M, Dork T, Bogdanova NV, Modugno F, Moysich K, Odunsi K, Ness R, Karlan BY, Lester J, Jensen A, Krüger Kjaer S, Høgdall E, Campbell IG, Lázaro C, Pujara MA, Cunningham J, Vierkant R, Winham SJ, Hildebrandt M, Huff C, Li D, Wu X, Yu Y, Permuth JB, Levine DA, Schildkraut JM, Riggan MJ, Berchuck A, Webb PM, Group OS, Cybulski C, Gronwald J, Jakubowska A, Lubinski J, Alsop J, Harrington P, Chan I, Menon U, Pearce CL, Wu AH, de Fazio A, Kennedy CJ, Goode E, Ramus S, Gayther S, Pharoah P. Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer. Journal of medical genetics 58(5):305-313, 2021. e-Pub 2021. PMID: 32546565.
- Hu F, Yu Y, Chen JS, Hu H, Scheet P, Huff CD. Integrated case-control and somatic-germline interaction analyses of soft-tissue sarcoma. Journal of medical genetics 58(3):145-153, 2021. e-Pub 2021. PMID: 32447321.
- Thompson BA, Snow AK, Koptiuch C, Kohlmann WK, Mooney R, Johnson S, Huff CD, Yu Y, Teerlink CC, Feng BJ, Neklason DW, Cannon-Albright LA, Tavtigian SV. A novel ribosomal protein S20 variant in a family with unexplained colorectal cancer and polyposis. Clin Genet 97(6):943-944, 2020. e-Pub 2020. PMID: 32424863.
- Thompson BA, Snow AK, Koptiuch C, Kohlmann WK, Mooney R, Johnson S, Huff C, Yu Y, Teerlink CC, Feng BJ, Neklason DW. A novel ribosomal protein S20 variant in a family with unexplained colorectal cancer and polyposis. bioRxiv, 2020. e-Pub 2020.
- Jakubek YA, Chang K, Sivakumar S, Yu Y, Giordano MR, Fowler J, Huff CD, Kadara H, Vilar E, Scheet P. Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer. Nat Biotechnol 38(1):90-96, 2020. e-Pub 2020. PMID: 31685958.
- Delisle BP, Yu Y, Puvvula P, Hall AR, Huff C, Moon AM. Tbx3-Mediated Regulation of Cardiac Conduction System Development and Function: Potential Contributions of Alternative RNA Processing. Pediatr Cardiol 40(7):1388-1400, 2019. e-Pub 2019. PMID: 31372681.
- Adam L, San Lucas FA, Fowler R, Yu Y, Wu W, Liu Y, Wang H, Menter D, Tetzlaff MT, Ensor J, Manyam G, Arold ST, Huff C, Kopetz S, Scheet P, Overman MJ. DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway. Clin Cancer Res 25(2):641-651, 2019. e-Pub 2019. PMID: 30352910.
- Teerlink CC, Huff C, Stevens J, Yu Y, Holmen SL, Silvis MR, Trombetti K, Zhao H, Grossman D, Farnham JM, Wen J, Facelli JC, Thomas A, Babst M, Florell SR, Meyer L, Zone JJ, Leachman S, Cannon-Albright LA. A Nonsynonymous Variant in the GOLM1 Gene in Cutaneous Malignant Melanoma. J Natl Cancer Inst 110(12):1380-1385, 2018. e-Pub 2018. PMID: 29659923.
- Loree JM, Bailey AM, Johnson AM, Yu Y, Wu W, Bristow CA, Davis JS, Shaw KR, Broaddus R, Banks KC, Lanman RB, Meric-Bernstam F, Overman MJ, Kopetz S, Raghav K. Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer. J Natl Cancer Inst 110(12):1409-1417, 2018. e-Pub 2018. PMID: 29718453.
- Logan CV, Murray JE, Parry DA, Robertson A, Bellelli R, Ž T, Challis R, Cleal L, Borel V, Fluteau A, Santoyo-Lopez J, Consortium SGP, Aitman T, Barroso I, Basel D, Bicknell LS, Goel H, Hu H, Huff C, Hutchison M, Joyce C, Knox R, Lacroix AE, Langlois S, McCandless S, McCarrier J, Metcalfe KA, Morrissey R, Murphy N, Netchine I, O'Connell SM, Olney AH, Paria N, Rosenfeld JA, Sherlock M, Syverson E, White PC, Wise C, Yu Y, Zacharin M, Banerjee I, Reijns M, Bober MB, Semple RK, Boulton SJ, Rios JJ, Jackson AP. DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency. Am J Hum Genet 103(6):1038-1044, 2018. e-Pub 2018. PMID: 30503519.
- Yu Y, Hu H, Chen JS, Hu F, Fowler J, Scheet P, Zhao H, Huff CD. Integrated case-control and somatic-germline interaction analyses of melanoma susceptibility genes. Biochim Biophys Acta Mol Basis Dis 1864(6 Pt B):2247-2254, 2018. e-Pub 2018. PMID: 29317335.
- Yu Y, Hu H, Bohlender RJ, Hu F, Chen JS, Holt C, Fowler J, Guthery SL, Scheet P, Hildebrandt MAT, Yandell M, Huff CD. XPAT: a toolkit to conduct cross-platform association studies with heterogeneous sequencing datasets. Nucleic Acids Res 46(6):e32, 2018. e-Pub 2018. PMID: 29294048.
- Lang Y, Pi X, Di Z, Zhang Q, Wang H, Shen B, Li F, Liu G, Yu Y, Li X, Wu Y, Li W, Cao Z. Molecular characterization and expression analysis of CSαβ defensin genes from the scorpion Mesobuthus martensii. Biosci Rep 37(6), 2017. e-Pub 2017. PMID: 29162666.
- Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD. Evolutionary history of Tibetans inferred from whole-genome sequencing. PLoS Genet 13(4):e1006675, 2017. e-Pub 2017. PMID: 28448578.
- Di DD, Jiang H, Tian LL, Kang JL, Zhang W, Yi XP, Ye F, Zhong Q, Ni B, He YY, Xia L, Yu Y, Cui BY, Mao X, Fan WX. Comparative genomic analysis between newly sequenced Brucella suis Vaccine Strain S2 and the Virulent Brucella suis Strain 1330. BMC Genomics 17(1):741, 2016. e-Pub 2016. PMID: 27645563.
- Yu Y, Zhou H, Kong Y, Pan B, Chen L, Wang H, Hao P, Li X. The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection. PLoS Genet 12(7):e1006191, 2016. e-Pub 2016. PMID: 27467689.
- Yan L, Qu S, Liu G, Liu L, Yu Y, Ding G, Zhao Y, Li Y, Xie Y, Zhang J, Qu D. Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection. PLoS One 11(2):e0149702, 2016. e-Pub 2016. PMID: 26900848.
- Kong Y, Zhou H, Yu Y, Chen L, Hao P, Li X. The evolutionary landscape of intergenic trans-splicing events in insects. Nat Commun 6:8734, 2015. e-Pub 2015. PMID: 26521696.
- Ramasamy R, Bakircioglu ME, Cengiz C, Karaca E, Scovell J, Jhangiani SN, Akdemir ZC, Bainbridge M, Yu Y, Huff C, Gibbs RA, Lupski JR, Lamb DJ. Whole-exome sequencing identifies novel homozygous mutation in NPAS2 in family with nonobstructive azoospermia. Fertil Steril 104(2):286-91, 2015. e-Pub 2015. PMID: 25956372.
- Li CF, Zhu Y, Yu Y, Zhao QY, Wang SJ, Wang XC, Yao MZ, Luo D, Li X, Chen L, Yang YJ. Global transcriptome and gene regulation network for secondary metabolite biosynthesis of tea plant (Camellia sinensis). BMC Genomics 16:560, 2015. e-Pub 2015. PMID: 26220550.
- Di Z, Yu Y, Wu Y, Hao P, He Y, Zhao H, Li Y, Zhao G, Li X, Li W, Cao Z. Genome-wide analysis of homeobox genes from Mesobuthus martensii reveals Hox gene duplication in scorpions. Insect Biochem Mol Biol 61:25-33, 2015. e-Pub 2015. PMID: 25910680.
- Wu Q, Peng S, Yu Y, Li Y, Xu Y. Genome Sequence of Bacillus licheniformis CGMCC3963, a Stress-Resistant Strain Isolated in a Chinese Traditional Solid-State Liquor-Making Process. Genome Announc 1(1), 2013. e-Pub 2013. PMID: 23405325.
- Cao Z, Yu Y, Wu Y, Hao P, Di Z, He Y, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X, Li Y, Li W. The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun 4:2602, 2013. e-Pub 2013. PMID: 24129506.
- Liu E, Zheng H, Hao P, Konno T, Yu Y, Kume H, Oda M, Ji ZS. A model of proteolysis and amino acid biosynthesis for Lactobacillus delbrueckii subsp. bulgaricus in whey. Curr Microbiol 65(6):742-51, 2012. e-Pub 2012. PMID: 22986815.
- Liu E, Hao P, Konno T, Yu Y, Oda M, Zheng H, Ji ZS. Amino acid biosynthesis and proteolysis in Lactobacillus bulgaricus revisited: a genomic comparison. Computational Molecular Bioscience 2(3), 2012. e-Pub 2012.
- Ping J, Wang Y, Yu Y, Li Y, Li X, Hao P. A comparative analysis of tissue gene expression data from high-throughput studies. Chinese Science Bulletin 57(22):2920-7, 2012. e-Pub 2012.
- Wang YJ, Wang JF, Ping J, Yu Y, Wang Y, Lian P, Li X, Li YX, Hao P. Computational studies on the substrate interactions of influenza A virus PB2 subunit. PLoS One 7(9):e44079, 2012. e-Pub 2012. PMID: 22957044.
- Wang Y, Yu Y, Pan B, Hao P, Li Y, Shao Z, Xu X, Li X. Optimizing hybrid assembly of next-generation sequence data from Enterococcus faecium: a microbe with highly divergent genome. BMC Syst Biol 6 Suppl 3:S21, 2012. e-Pub 2012. PMID: 23282199.
- Hao P, Zheng H, Yu Y, Ding G, Gu W, Chen S, Yu Z, Ren S, Oda M, Konno T, Wang S, Li X, Ji ZS, Zhao G. Complete sequencing and pan-genomic analysis of Lactobacillus delbrueckii subsp. bulgaricus reveal its genetic basis for industrial yogurt production. PLoS One 6(1):e15964, 2011. e-Pub 2011. PMID: 21264216.
- Xu T, Ping J, Yu Y, Yu F, Yu Y, Hao P, Li X. Revealing parasite influence in metabolic pathways in Apicomplexa infected patients. BMC Bioinformatics 11 Suppl 11:S13, 2010. e-Pub 2010. PMID: 21172048.
- Yu Y, Xu T, Yu Y, Hao P, Li X. Association of tissue lineage and gene expression: conservatively and differentially expressed genes define common and special functions of tissues. BMC Bioinformatics 11 Suppl 11:S1, 2010. e-Pub 2010. PMID: 21172044.
- Yu Y, Ping J, Chen H, Jiao L, Zheng S, Han ZG, Hao P, Huang J. A comparative analysis of liver transcriptome suggests divergent liver function among human, mouse and rat. Genomics 96(5):281-9, 2010. e-Pub 2010. PMID: 20800674.
- Yu Y, Tu K, Zheng S, Li Y, Ding G, Ping J, Hao P, Li Y. GEOGLE: context mining tool for the correlation between gene expression and the phenotypic distinction. BMC Bioinformatics 10:264, 2009. e-Pub 2009. PMID: 19703314.
- Hao P, Yu Y, Zhang X, Tu K, Fan H, Zhong Y. The contribution of cis-regulatory elements to head-to-head gene pairs' co-expression pattern. Sci China C Life Sci 52(1):74-9, 2009. e-Pub 2009. PMID: 19152086.
- Zheng S, Sheng J, Wang C, Wang X, Yu Y, Li Y, Michie A, Dai J, Zhong Y, Hao P, Liu L, Li Y. MPSQ: a web tool for protein-state searching. Bioinformatics 24(20):2412-3, 2008. e-Pub 2008. PMID: 18697766.
- Wang-Sattler R, Yu Y, Mittelstrass K, Lattka E, Altmaier E, Gieger C, Ladwig KH, Dahmen N, Weinberger KM, Hao P, Liu L, Li Y, Wichmann HE, Adamski J, Suhre K, Illig T. Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study. PLoS One 3(12):e3863, 2008. e-Pub 2008. PMID: 19057651.
Review Articles
- Yu Y, Li X, Hao P, Wang JF, Chou KC. Research/review: Structure and linkage disequilibrium analysis of adamantane resistant mutations in influenza virus m2 proton channel. Curr Drug Metab 15(5):526-34, 2014. e-Pub 2014. PMID: 24909420.
Abstracts
- Venkatesh N, Tidwell R, Yu Y, Aparicio A, Zurita AJ, Subudhi SK, Siddiqui BA, Gregg JR, Corn PG, Msaouel P, Koutroumpakis E, McQuade JL, Frigo D, Pilié PG, Logothetis C, Huff C, Hahn AW. Association of inherited steroidogenic genotype with body composition changes after androgen signaling inhibition (ASI) in men with biochemical recurrent (BCR), hormone-sensitive prostate cancer (HSPC). Journal of Clinical Oncology, 2024. e-Pub 2024.
Book Chapters
- Yu Y. Understanding of bioinformatics (Chinese Edition). In: Chapter 5: Sequence Alignments. Science Press, 2012.
Patient Reviews
CV information above last modified July 22, 2026